ホームページ MAPK Raf inhibitor - VEGFR inhibitor - PDGFR inhibitor - FLT3 inhibitor - Autophagy activator - Apoptosis related activator - Ferroptosis activator Sorafenib For research use only.

Sorafenib

別名：NSC-724772,BAY 43-9006

Sorafenib is a multikinase inhibitor of Raf-1 and B-Raf with IC50 of 6 nM and 22 nM in cell-free assays, respectively. Sorafenib inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3 and c-KIT with IC50 of 90 nM, 20 nM, 57 nM, 59 nM and 68 nM, respectively. Sorafenib induces autophagy and apoptosis and activates ferroptosis with anti-tumor activity.

Sorafenib化学構造

CAS No. 284461-73-0

サイズ 価格(税別) 在庫状況
10mM (1mL in DMSO) JPY 29500 国内在庫あり
JPY 22000 国内在庫あり
JPY 40500 国内在庫あり
JPY 74500 国内在庫あり
JPY 145500 国内在庫あり
JPY 220500 国内在庫あり

代表番号: 045-509-1970|電子メール：[email protected]
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文献中Selleckの製品使用例（553）

製品安全説明書

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Sorafenib関連製品

シグナル伝達経路

Raf Signaling Pathways

Rafシグナル伝達経路

Raf阻害剤の選択性比較

Cell Data

Cell Lines Assay Type Concentration Incubation Time 活性情報 PMID
OS-RC-2 Growth Inhibition Assay IC50=9.11243 μM SANGER
LC-1F Growth Inhibition Assay IC50=9.10834 μM SANGER
TE-10 Growth Inhibition Assay IC50=8.76353 μM SANGER
HD-MY-Z Growth Inhibition Assay IC50=8.63746 μM SANGER
NB14 Growth Inhibition Assay IC50=8.63133 μM SANGER
IST-MEL1 Growth Inhibition Assay IC50=8.40002 μM SANGER
RPMI-8226 Growth Inhibition Assay IC50=7.84511 μM SANGER
ES8 Growth Inhibition Assay IC50=7.76503 μM SANGER
D-392MG Growth Inhibition Assay IC50=7.62663 μM SANGER
NB1 Growth Inhibition Assay IC50=7.40407 μM SANGER
697 Growth Inhibition Assay IC50=7.05989 μM SANGER
DOHH-2 Growth Inhibition Assay IC50=7.05676 μM SANGER
SIMA Growth Inhibition Assay IC50=7.00101 μM SANGER
OCI-AML2 Growth Inhibition Assay IC50=6.61062 μM SANGER
ML-2 Growth Inhibition Assay IC50=6.52849 μM SANGER
SW954 Growth Inhibition Assay IC50=6.45866 μM SANGER
MZ2-MEL Growth Inhibition Assay IC50=6.31839 μM SANGER
MOLT-16 Growth Inhibition Assay IC50=6.25266 μM SANGER
SR Growth Inhibition Assay IC50=6.00678 μM SANGER
BV-173 Growth Inhibition Assay IC50=5.95682 μM SANGER
no-11 Growth Inhibition Assay IC50=5.73568 μM SANGER
JAR Growth Inhibition Assay IC50=5.50824 μM SANGER
NCI-H510A Growth Inhibition Assay IC50=5.41685 μM SANGER
TE-12 Growth Inhibition Assay IC50=5.24929 μM SANGER
SF539 Growth Inhibition Assay IC50=5.13227 μM SANGER
QIMR-WIL Growth Inhibition Assay IC50=5.07294 μM SANGER
NOMO-1 Growth Inhibition Assay IC50=4.48905 μM SANGER
MHH-PREB-1 Growth Inhibition Assay IC50=4.40484 μM SANGER
NCI-H1581 Growth Inhibition Assay IC50=4.28798 μM SANGER
BC-3 Growth Inhibition Assay IC50=4.23391 μM SANGER
SK-NEP-1 Growth Inhibition Assay IC50=4.16815 μM SANGER
KS-1 Growth Inhibition Assay IC50=3.88198 μM SANGER
ST486 Growth Inhibition Assay IC50=3.83673 μM SANGER
BC-1 Growth Inhibition Assay IC50=3.7402 μM SANGER
MZ7-mel Growth Inhibition Assay IC50=3.66099 μM SANGER
MRK-nu-1 Growth Inhibition Assay IC50=3.61468 μM SANGER
MZ1-PC Growth Inhibition Assay IC50=3.47509 μM SANGER
TE-5 Growth Inhibition Assay IC50=3.13162 μM SANGER
HCC2218 Growth Inhibition Assay IC50=3.12003 μM SANGER
HL-60 Growth Inhibition Assay IC50=3.06299 μM SANGER
MFH-ino Growth Inhibition Assay IC50=2.92185 μM SANGER
KMOE-2 Growth Inhibition Assay IC50=2.8135 μM SANGER
L-540 Growth Inhibition Assay IC50=2.75789 μM SANGER
K052 Growth Inhibition Assay IC50=2.74616 μM SANGER
BE-13 Growth Inhibition Assay IC50=2.69609 μM SANGER
SIG-M5 Growth Inhibition Assay IC50=2.42242 μM SANGER
NCI-H2171 Growth Inhibition Assay IC50=2.39764 μM SANGER
NCI-SNU-1 Growth Inhibition Assay IC50=2.3162 μM SANGER
OVCAR-4 Growth Inhibition Assay IC50=2.21393 μM SANGER
D-247MG Growth Inhibition Assay IC50=2.1448 μM SANGER
A3-KAW Growth Inhibition Assay IC50=1.8842 μM SANGER
MEG-01 Growth Inhibition Assay IC50=1.8098 μM SANGER
SF126 Growth Inhibition Assay IC50=1.63812 μM SANGER
no-10 Growth Inhibition Assay IC50=1.61726 μM SANGER
A388 Growth Inhibition Assay IC50=1.59165 μM SANGER
KG-1 Growth Inhibition Assay IC50=1.47935 μM SANGER
LAMA-84 Growth Inhibition Assay IC50=1.37648 μM SANGER
EM-2 Growth Inhibition Assay IC50=1.35578 μM SANGER
NCI-H1436 Growth Inhibition Assay IC50=1.21678 μM SANGER
LB2518-MEL Growth Inhibition Assay IC50=1.20809 μM SANGER
KM12 Growth Inhibition Assay IC50=1.02098 μM SANGER
GDM-1 Growth Inhibition Assay IC50=0.90698 μM SANGER
HCC2998 Growth Inhibition Assay IC50=0.88818 μM SANGER
HOP-62 Growth Inhibition Assay IC50=0.85088 μM SANGER
SH-4 Growth Inhibition Assay IC50=0.65613 μM SANGER
NOS-1 Growth Inhibition Assay IC50=0.5636 μM SANGER
BB65-RCC Growth Inhibition Assay IC50=0.47073 μM SANGER
CGTH-W-1 Growth Inhibition Assay IC50=0.25022 μM SANGER
NKM-1 Growth Inhibition Assay IC50=0.07416 μM SANGER
ALL-PO Growth Inhibition Assay IC50=0.03184 μM SANGER
MONO-MAC-6 Growth Inhibition Assay IC50=0.00418 μM SANGER
MV-4-11 Growth Inhibition Assay IC50=0.00000303 μM SANGER
NCI-SNU-16 Growth Inhibition Assay IC50=9.21026 μM SANGER
SHP-77 Growth Inhibition Assay IC50=9.71662 μM SANGER
A4-Fuk Growth Inhibition Assay IC50=9.7561 μM SANGER
NB6 Growth Inhibition Assay IC50=9.76029 μM SANGER
JiyoyeP-2003 Growth Inhibition Assay IC50=10.4745 μM SANGER
DMS-114 Growth Inhibition Assay IC50=10.5441 μM SANGER
NB7 Growth Inhibition Assay IC50=10.7526 μM SANGER
NCI-H747 Growth Inhibition Assay IC50=11.1216 μM SANGER
HH Growth Inhibition Assay IC50=11.3876 μM SANGER
EW-18 Growth Inhibition Assay IC50=11.9044 μM SANGER
CHP-126 Growth Inhibition Assay IC50=11.9738 μM SANGER
NTERA-S-cl-D1 Growth Inhibition Assay IC50=12.0278 μM SANGER
DEL Growth Inhibition Assay IC50=12.0985 μM SANGER
LU-139 Growth Inhibition Assay IC50=12.5413 μM SANGER
P30-OHK Growth Inhibition Assay IC50=12.5479 μM SANGER
NCI-H1522 Growth Inhibition Assay IC50=12.746 μM SANGER
NCI-H1299 Growth Inhibition Assay IC50=13.2911 μM SANGER
UACC-257 Growth Inhibition Assay IC50=13.5126 μM SANGER
Calu-6 Growth Inhibition Assay IC50=13.6046 μM SANGER
NCI-H1882 Growth Inhibition Assay IC50=13.8555 μM SANGER
BB30-HNC Growth Inhibition Assay IC50=14.0609 μM SANGER
ES1 Growth Inhibition Assay IC50=14.1551 μM SANGER
NCI-H1694 Growth Inhibition Assay IC50=14.4811 μM SANGER
IST-SL1 Growth Inhibition Assay IC50=14.9616 μM SANGER
ECC4 Growth Inhibition Assay IC50=15.0558 μM SANGER
MDA-MB-134-VI Growth Inhibition Assay IC50=15.4131 μM SANGER
SCH Growth Inhibition Assay IC50=15.4728 μM SANGER
SK-N-FI Growth Inhibition Assay IC50=15.6534 μM SANGER
HDLM-2 Growth Inhibition Assay IC50=16.0714 μM SANGER
Ramos-2G6-4C10 Growth Inhibition Assay IC50=16.1297 μM SANGER
EW-24 Growth Inhibition Assay IC50=16.1661 μM SANGER
NCI-H2141 Growth Inhibition Assay IC50=16.189 μM SANGER
LC4-1 Growth Inhibition Assay IC50=16.6119 μM SANGER
HT-144 Growth Inhibition Assay IC50=17.006 μM SANGER
SK-MEL-1 Growth Inhibition Assay IC50=17.0072 μM SANGER
SCC-15 Growth Inhibition Assay IC50=17.1638 μM SANGER
C8166 Growth Inhibition Assay IC50=17.6833 μM SANGER
GOTO Growth Inhibition Assay IC50=17.8344 μM SANGER
COR-L279 Growth Inhibition Assay IC50=18.1362 μM SANGER
K-562 Growth Inhibition Assay IC50=18.7143 μM SANGER
ES3 Growth Inhibition Assay IC50=18.8041 μM SANGER
LU-165 Growth Inhibition Assay IC50=19.7008 μM SANGER
KM-H2 Growth Inhibition Assay IC50=20.3184 μM SANGER
RL Growth Inhibition Assay IC50=20.9692 μM SANGER
EW-3 Growth Inhibition Assay IC50=21.1889 μM SANGER
A101D Growth Inhibition Assay IC50=21.3752 μM SANGER
HUTU-80 Growth Inhibition Assay IC50=21.3946 μM SANGER
NCI-H23 Growth Inhibition Assay IC50=21.3992 μM SANGER
PF-382 Growth Inhibition Assay IC50=21.4403 μM SANGER
LB373-MEL-D Growth Inhibition Assay IC50=21.5615 μM SANGER
TE-8 Growth Inhibition Assay IC50=21.6394 μM SANGER
TE-9 Growth Inhibition Assay IC50=21.8513 μM SANGER
Daudi Growth Inhibition Assay IC50=21.9304 μM SANGER
D-542MG Growth Inhibition Assay IC50=22.0256 μM SANGER
U-698-M Growth Inhibition Assay IC50=22.4603 μM SANGER
ES6 Growth Inhibition Assay IC50=22.7366 μM SANGER
DU-4475 Growth Inhibition Assay IC50=23.8897 μM SANGER
ECC12 Growth Inhibition Assay IC50=24.2803 μM SANGER
C2BBe1 Growth Inhibition Assay IC50=24.3239 μM SANGER
IST-SL2 Growth Inhibition Assay IC50=24.4362 μM SANGER
DJM-1 Growth Inhibition Assay IC50=24.5221 μM SANGER
DMS-153 Growth Inhibition Assay IC50=24.8614 μM SANGER
NB13 Growth Inhibition Assay IC50=25.0265 μM SANGER
SK-N-DZ Growth Inhibition Assay IC50=26.3414 μM SANGER
COR-L88 Growth Inhibition Assay IC50=26.5796 μM SANGER
LU-65 Growth Inhibition Assay IC50=26.8535 μM SANGER
TGBC1TKB Growth Inhibition Assay IC50=26.9828 μM SANGER
THP-1 Growth Inhibition Assay IC50=27.2141 μM SANGER
ONS-76 Growth Inhibition Assay IC50=27.332 μM SANGER
LC-2-ad Growth Inhibition Assay IC50=27.6231 μM SANGER
EW-13 Growth Inhibition Assay IC50=29.1746 μM SANGER
MS-1 Growth Inhibition Assay IC50=30.7278 μM SANGER
NCI-H2227 Growth Inhibition Assay IC50=30.9806 μM SANGER
LXF-289 Growth Inhibition Assay IC50=31.4492 μM SANGER
MC116 Growth Inhibition Assay IC50=32.0826 μM SANGER
EVSA-T Growth Inhibition Assay IC50=32.2585 μM SANGER
CTB-1 Growth Inhibition Assay IC50=33.1101 μM SANGER
COLO-320-HSR Growth Inhibition Assay IC50=33.1603 μM SANGER
NCI-H2196 Growth Inhibition Assay IC50=33.2557 μM SANGER
LB2241-RCC Growth Inhibition Assay IC50=33.3135 μM SANGER
LS-513 Growth Inhibition Assay IC50=33.8638 μM SANGER
LP-1 Growth Inhibition Assay IC50=33.9956 μM SANGER
A253 Growth Inhibition Assay IC50=34.2296 μM SANGER
SK-MM-2 Growth Inhibition Assay IC50=34.9451 μM SANGER
NCI-H1963 Growth Inhibition Assay IC50=35.3072 μM SANGER
MMAC-SF Growth Inhibition Assay IC50=35.8785 μM SANGER
LB831-BLC Growth Inhibition Assay IC50=36.0654 μM SANGER
WSU-NHL Growth Inhibition Assay IC50=36.164 μM SANGER
CESS Growth Inhibition Assay IC50=36.2848 μM SANGER
NEC8 Growth Inhibition Assay IC50=36.5835 μM SANGER
KNS-42 Growth Inhibition Assay IC50=37.1237 μM SANGER
MHH-CALL-2 Growth Inhibition Assay IC50=37.1821 μM SANGER
K5 Growth Inhibition Assay IC50=38.43 μM SANGER
CP66-MEL Growth Inhibition Assay IC50=39.0733 μM SANGER
OPM-2 Growth Inhibition Assay IC50=39.8432 μM SANGER
IST-MES1 Growth Inhibition Assay IC50=40.3096 μM SANGER
EC-GI-10 Growth Inhibition Assay IC50=41.5805 μM SANGER
CTV-1 Growth Inhibition Assay IC50=42.8406 μM SANGER
DG-75 Growth Inhibition Assay IC50=43.7595 μM SANGER
KNS-81-FD Growth Inhibition Assay IC50=45.4058 μM SANGER
NCI-H82 Growth Inhibition Assay IC50=45.5758 μM SANGER
RPMI-8866 Growth Inhibition Assay IC50=46.1873 μM SANGER
ACN Growth Inhibition Assay IC50=46.434 μM SANGER
NCI-H1395 Growth Inhibition Assay IC50=46.4756 μM SANGER
NCI-H209 Growth Inhibition Assay IC50=47.1405 μM SANGER
TGW Growth Inhibition Assay IC50=49.0791 μM SANGER
NCI-H748 Growth Inhibition Assay IC50=49.4753 μM SANGER
EKVX Growth Inhibition Assay IC50=49.6628 μM SANGER
MV4-11 Antiproliferative activity assay IC50 = 0.00087 μM 19754199
MV4-11 Cytotoxicity assay IC50 = 0.00087 μM 19654408
TT Antiproliferative activity assay IC50 = 0.0014 μM 18849971
RS4-11 Function assay IC50 = 0.002 μM 19654408
MOLM13 Function assay IC50 = 0.002 μM 24641103
Sf9 Function assay IC50 = 0.003 μM 21708468
RS4-11 Function assay IC50 = 0.0032 μM 19654408
MV4-11 Growth inhibition assay IC50 = 0.004 μM 29357250
A375 Function assay IC50 = 0.0044 μM 29461827
MOLM13 Antiproliferative activity assay IC50 = 0.005 μM 24641103
MV4-11 Function assay IC50 = 0.007 μM 23362959
MV4-11 Cytotoxicity assay IC50 = 0.007 μM 26342867
HEK293 Function assay Kd = 0.013 μM 19754199
Kasumi-1 Antiproliferative activity assay IC50 = 0.015 μM 20570526
MV4-11 Antiproliferative activity assay IC50 = 0.015 μM 20570526
sf9 Function assay IC50 = 0.015 μM 29266937
sf9 Function assay IC50 = 0.018 μM 21708468
sf9 Function assay IC50 = 0.02 μM 23618709
MV4-11 Antiproliferative activity assay GI50 = 0.03 μM 21708468
Sf9 Function assay IC50 = 0.042 μM 26081023
SF9 Function assay IC50 = 0.043 μM 18473434
MV4-11 Cytotoxicity assay GI50 = 0.043 μM 23618709
MV4-11 Function assay GI50 = 0.043 μM 26081023
SF9 Function assay IC50 = 0.044 μM 26081023
SF9 Function assay IC50 = 0.054 μM 21708468
SF9 Function assay IC50 = 0.054 μM 23618709
MOLM13 Antiproliferative activity assay GI50 = 0.056 μM 21708468
MOLM13 Antiproliferative activity assay GI50 = 0.056 μM 22726931
MOLM13 Cytotoxicity assay GI50 = 0.056 μM 23618709
MOLM-13 Function assay GI50 = 0.056 μM 26081023
SF9 Function assay IC50 = 0.058 μM 29266937
WM266.4 Antiproliferative activity assay IC50 = 0.06 μM 25496804
MDA-MB-231 Function assay IC50 = 0.063 μM 28431342
SF9 Function assay IC50 = 0.09 μM 29266937
Spodoptera frugiperda Function assay IC50 = 0.09 μM 26922228
SF9 Function assay IC50 = 0.09 μM 23562241
SF9 Function assay IC50 = 0.1 μM 23442188
SF9 Function assay IC50 = 0.1 μM 23442188
HEK293 Function assay IC50 = 0.12 μM 26318998
MCF7 Antiproliferative activity assay IC50 = 0.19 μM 25496804
MV4-11 Antiproliferative activity human IC50 = 0.3 μM 28242553
HepG2 Antiproliferative activity assay EC50 = 0.302 μM 27010810
THP1 Antiproliferative activity assay IC50 = 0.31 μM 20570526
SMMC7721 Cytotoxicity assay IC50 = 0.37 μM 25982075
HT-29 Antiproliferative activity assay IC50 = 0.39 μM 25778995
sf9 Function assay Kd = 0.6 μM 28109791
T47D Antiproliferative activity assay IC50 = 0.61 μM 25778995
A549 Cytotoxicity assay IC50 = 0.63 μM 25982075
HeLa Cytotoxicity assay IC50 = 0.64 μM 30015070
WM3629 Antiproliferative activity assay GI50 = 0.65 μM 20466542
SMMC7721 Antiproliferative activity assay IC50 = 0.65 μM 26342134
WM3629 Growth inhibition assay GI50 = 0.78 μM 20149658
WM3629 Antiproliferative activity assay GI50 = 0.78 μM 26810260
MCF7 Antiproliferative activity assay IC50 = 0.78 μM 25778995
K562 Antiproliferative activity assay IC50 = 0.86 μM 24315192
COLO205 Antiproliferative activity assay IC50 = 0.87 μM 25778995
T29 Cytotoxicity assay IC50 = 0.9 μM 26318998
MDA-MB-231 Cytotoxicity assay IC50 = 0.94 μM 25086238
MDA-MB-231 Cytotoxicity assay IC50 = 0.94 μM 25440879
HepG2 Antiproliferative activity assay IC50 = 1.06 μM 29628325
BL21(DE3) Function assay IC50 = 1.1 μM 19928858
K562 Antiproliferative activity assay IC50 = 1.22 μM 25778995
MDA-MB-231 Growth inhibition assay GI50 = 1.26 μM 28088086
MDA-MB-231 Cytotoxicity assay GI50 = 1.26 μM 26590508
MDA-MB-231 Antiproliferative activity assay GI50 = 1.26 μM 27017549
SK-MEL-28 Antiproliferative activity assay EC50 = 1.3 μM 18942827
sf9 Function assay Kd = 1.3 μM 28109791
F-6-8 Cytotoxicity assay IC50 = 1.3 μM 26318998
A549 Antiproliferative activity assay IC50 = 1.45 μM 26342134
rhabdomyosarcoma Antiviral activity assay EC50 = 1.5 μM 27288186
HL-60(TB) Growth inhibition assay GI50 = 1.58 μM 28088086
RPMI8226 Growth inhibition assay GI50 = 1.58 μM 28088086
KM12 Growth inhibition assay GI50 = 1.58 μM 28088086
LOXIMVI Growth inhibition assay GI50 = 1.58 μM 28088086
HCT116 Growth inhibition assay GI50 = 1.58 μM 28088086
HOP92 Growth inhibition assay GI50 = 1.58 μM 28088086
SF539 Growth inhibition assay GI50 = 1.58 μM 28088086
UACC62 Growth inhibition assay GI50 = 1.58 μM 28088086
SF295 Growth inhibition assay GI50 = 1.58 μM 28088086
MDA-MB-435 Growth inhibition assay GI50 = 1.58 μM 28088086
SK-MEL-5 Growth inhibition assay GI50 = 1.58 μM 28088086
T47D Growth inhibition assay GI50 = 1.58 μM 28088086
RPMI8266 Cytotoxicity assay GI50 = 1.58 μM 26590508
HL-60(TB) Cytotoxicity assay GI50 = 1.58 μM 26590508
KM12 Cytotoxicity assay GI50 = 1.58 μM 26590508
HCT116 Cytotoxicity assay GI50 = 1.58 μM 26590508
SF295 Cytotoxicity assay GI50 = 1.58 μM 26590508
SF539 Cytotoxicity assay GI50 = 1.58 μM 26590508
SK-MEL-2 Cytotoxicity assay GI50 = 1.58 μM 26590508
MDA-MB-435 Cytotoxicity assay GI50 = 1.58 μM 26590508
SK-MEL-5 Cytotoxicity assay GI50 = 1.58 μM 26590508
LOXIMVI Cytotoxicity assay GI50 = 1.58 μM 26590508
T47D Cytotoxicity assay GI50 = 1.58 μM 26590508
SMMC7721 Antiproliferative activity assay IC50 = 1.58 μM 26753815
LOXIMVI Antiproliferative activity assay GI50 = 1.58 μM 27017549
UACC62 Antiproliferative activity assay GI50 = 1.58 μM 27017549
SK-MEL-5 Antiproliferative activity assay GI50 = 1.58 μM 27017549
KM12 Antiproliferative activity assay GI50 = 1.58 μM 27017549
MDA-MB-435 Antiproliferative activity assay GI50 = 1.58 μM 27017549
SF539 Antiproliferative activity assay GI50 = 1.58 μM 27017549
SF295 Antiproliferative activity assay GI50 = 1.58 μM 27017549
HCT116 Antiproliferative activity assay GI50 = 1.58 μM 27017549
HOP92 Antiproliferative activity assay GI50 = 1.58 μM 27017549
RPMI8226 Antiproliferative activity assay GI50 = 1.58 μM 27017549
HL-60(TB) Antiproliferative activity assay GI50 = 1.58 μM 27017549
T47D Antiproliferative activity assay GI50 = 1.58 μM 27017549
7dF3 Function assay IC50 = 1.62 μM 29266937
MDA-MB-435 Antiproliferative activity assay IC50 = 1.67 μM 25778995
HL60 Cytotoxicity assay IC50 = 1.68 μM 24858546
SW579 Antiproliferative activity human IC50 = 1.73 μM 28242553
MCF7 Antiproliferative activity assay IC50 = 1.88 μM 25637123
A375P Antiproliferative activity assay IC50 = 1.9 μM 24128410
A549 Cytotoxicity assay IC50 = 1.92 μM 24826815
HCT116 Antiproliferative activity assay IC50 = 2 μM 22808911
MDA-MB-231 Cytotoxicity assay IC50 = 2 μM 23454017
NCI-H23 Growth inhibition assay GI50 = 2 μM 28088086
NCI-H522 Growth inhibition assay GI50 = 2 μM 28088086
HOP62 Growth inhibition assay GI50 = 2 μM 28088086
NCI-H226 Growth inhibition assay GI50 = 2 μM 28088086
HT-29 Growth inhibition assay GI50 = 2 μM 28088086
U251 Growth inhibition assay GI50 = 2 μM 28088086
COLO205 Growth inhibition assay GI50 = 2 μM 28088086
CCRF-CEM Growth inhibition assay GI50 = 2 μM 28088086
MALME-3M Growth inhibition assay GI50 = 2 μM 28088086
M14 Growth inhibition assay GI50 = 2 μM 28088086
UACC257 Growth inhibition assay GI50 = 2 μM 28088086
PC3 Growth inhibition assay GI50 = 2 μM 28088086
SK-MEL-2 Growth inhibition assay GI50 = 2 μM 28088086
MDA-MB-468 Growth inhibition assay GI50 = 2 μM 28088086
CCRF-CEM Cytotoxicity assay GI50 = 2 μM 26590508
NCI-H23 Cytotoxicity assay GI50 = 2 μM 26590508
NCI-H522 Cytotoxicity assay GI50 = 2 μM 26590508
COLO205 Cytotoxicity assay GI50 = 2 μM 26590508
HT-29 Cytotoxicity assay GI50 = 2 μM 26590508
SK-MEL-28 Cytotoxicity assay GI50 = 2 μM 26590508
HOP62 Cytotoxicity assay GI50 = 2 μM 26590508
UACC257 Cytotoxicity assay GI50 = 2 μM 26590508
NCI-H226 Cytotoxicity assay GI50 = 2 μM 26590508
U251 Cytotoxicity assay GI50 = 2 μM 26590508
PC3 Cytotoxicity assay GI50 = 2 μM 26590508
M14 Cytotoxicity assay GI50 = 2 μM 26590508
MDA-MB-468 Cytotoxicity assay GI50 = 2 μM 26590508
PC3 Antiproliferative activity assay GI50 = 2 μM 27017549
MALME-3M Antiproliferative activity assay GI50 = 2 μM 27017549
U251 Antiproliferative activity assay GI50 = 2 μM 27017549
UACC257 Antiproliferative activity assay GI50 = 2 μM 27017549
SK-MEL-2 Antiproliferative activity assay GI50 = 2 μM 27017549
COLO205 Antiproliferative activity assay GI50 = 2 μM 27017549
NCI-H23 Antiproliferative activity assay GI50 = 2 μM 27017549
HT-29 Antiproliferative activity assay GI50 = 2 μM 27017549
M14 Antiproliferative activity assay GI50 = 2 μM 27017549
NCI-H226 Antiproliferative activity assay GI50 = 2 μM 27017549
HOP62 Antiproliferative activity assay GI50 = 2 μM 27017549
MDA-MB-468 Antiproliferative activity assay GI50 = 2 μM 27017549
CCRF-CEM Antiproliferative activity assay GI50 = 2 μM 27017549
NCI-H522 Antiproliferative activity assay GI50 = 2 μM 27017549
A549 Antiproliferative activity assay IC50 = 2.02 μM 26753815
MDA-MB-435 Growth inhibition assay IC50 = 2.11 μM 29189002
NCI-H460 Antiproliferative activity assay IC50 = 2.19 μM 30216849
H460 Cytotoxicity assay IC50 = 2.19 μM 24826815
H460 Cytotoxicity assay IC50 = 2.19 μM 25086238
H460 Cytotoxicity assay IC50 = 2.19 μM 25440879
A375 Toxicity assay IC50 = 2.2 μM 19654408
H460 Antiproliferative activity assay IC50 = 2.25 μM 26991938
HCT116 Antiproliferative activity assay IC50 = 2.3 μM 23260578
MKN45 Antiproliferative activity assay IC50 = 2.32 μM 30216849
MKN45 Cytotoxicity assay IC50 = 2.32 μM 24826815
MKN45 Cytotoxicity assay IC50 = 2.32 μM 25086238
MKN45 Cytotoxicity assay IC50 = 2.32 μM 25440879
U937 Antiproliferative activity assay GI50 = 2.34 μM 29459144
A375 Antiproliferative activity assay IC50 = 2.4 μM 22808911
HeLa Growth inhibition assay IC50 = 2.44 μM 29102175
MDA-MB-231 Cytotoxicity assay IC50 = 2.5 μM 22414612
MCF7 Antiproliferative activity assay IC50 = 2.51 μM 30216849
UO31 Antiproliferative activity assay IC50 = 2.51 μM 30216849
NCI-H322M Growth inhibition assay GI50 = 2.51 μM 28088086
NCI-H460 Growth inhibition assay GI50 = 2.51 μM 28088086
KM12 Growth inhibition assay TGI = 2.51 μM 28088086
LOXIMVI Growth inhibition assay TGI = 2.51 μM 28088086
EKVX Growth inhibition assay GI50 = 2.51 μM 28088086
HCT116 Growth inhibition assay TGI = 2.51 μM 28088086
SW620 Growth inhibition assay GI50 = 2.51 μM 28088086
SF268 Growth inhibition assay GI50 = 2.51 μM 28088086
SF539 Growth inhibition assay TGI = 2.51 μM 28088086
A498 Growth inhibition assay GI50 = 2.51 μM 28088086
UACC62 Growth inhibition assay TGI = 2.51 μM 28088086
IGROV1 Growth inhibition assay GI50 = 2.51 μM 28088086
HCT15 Growth inhibition assay GI50 = 2.51 μM 28088086
SK-MEL-28 Growth inhibition assay GI50 = 2.51 μM 28088086
SK-MEL-28 Growth inhibition assay TGI = 2.51 μM 28088086
ACHN Growth inhibition assay GI50 = 2.51 μM 28088086
SK-MEL-5 Growth inhibition assay TGI = 2.51 μM 28088086
NCI/ADR-RES Growth inhibition assay GI50 = 2.51 μM 28088086
MCF7 Growth inhibition assay GI50 = 2.51 μM 28088086
SN12C Growth inhibition assay GI50 = 2.51 μM 28088086
Hs 578T Growth inhibition assay GI50 = 2.51 μM 28088086
SKOV3 Growth inhibition assay GI50 = 2.51 μM 28088086
UO31 Growth inhibition assay GI50 = 2.51 μM 28088086
NCI-H460 Cytotoxicity assay GI50 = 2.51 μM 26590508
HCT15 Cytotoxicity assay GI50 = 2.51 μM 26590508
SW620 Cytotoxicity assay GI50 = 2.51 μM 26590508
SF268 Cytotoxicity assay GI50 = 2.51 μM 26590508
IGROV1 Cytotoxicity assay GI50 = 2.51 μM 26590508
OVCAR8 Cytotoxicity assay GI50 = 2.51 μM 26590508
NCI/ADR-RES Cytotoxicity assay GI50 = 2.51 μM 26590508
SKOV3 Cytotoxicity assay GI50 = 2.51 μM 26590508
SN12C Cytotoxicity assay GI50 = 2.51 μM 26590508
NCI-H322M Cytotoxicity assay GI50 = 2.51 μM 26590508
MCF7 Cytotoxicity assay GI50 = 2.51 μM 26590508
UO31 Cytotoxicity assay GI50 = 2.51 μM 26590508
Hs578T Cytotoxicity assay GI50 = 2.51 μM 26590508
A498 Cytotoxicity assay GI50 = 2.51 μM 26590508
A498 Antiproliferative activity assay GI50 = 2.51 μM 27017549
SKOV3 Antiproliferative activity assay GI50 = 2.51 μM 27017549
UO31 Antiproliferative activity assay GI50 = 2.51 μM 27017549
NCI-ADR-RES Antiproliferative activity assay GI50 = 2.51 μM 27017549
SN12C Antiproliferative activity assay GI50 = 2.51 μM 27017549
IGROV1 Antiproliferative activity assay GI50 = 2.51 μM 27017549
ACHN Antiproliferative activity assay GI50 = 2.51 μM 27017549
OVCAR8 Antiproliferative activity assay GI50 = 2.51 μM 27017549
SK-MEL-28 Antiproliferative activity assay GI50 = 2.51 μM 27017549
NCI-H322M Antiproliferative activity assay GI50 = 2.51 μM 27017549
SF268 Antiproliferative activity assay GI50 = 2.51 μM 27017549
HCT15 Antiproliferative activity assay GI50 = 2.51 μM 27017549
NCI-H460 Antiproliferative activity assay GI50 = 2.51 μM 27017549
SW620 Antiproliferative activity assay GI50 = 2.51 μM 27017549
EKVX Antiproliferative activity assay GI50 = 2.51 μM 27017549
MCF7 Antiproliferative activity assay GI50 = 2.51 μM 27017549
Hs 578T Antiproliferative activity assay GI50 = 2.51 μM 27017549
HT-29 Antiproliferative activity assay IC50 = 2.58 μM 29886324
A375P Antiproliferative activity assay GI50 = 2.58 μM 26810260
TPC1 Antiproliferative activity assay EC50 = 2.6 μM 22559926
Hep3B Growth inhibition assay IC50 = 2.63 μM 29102175
A375P Antiproliferative activity assay IC50 = 2.7 μM 22460030
U937 Antiproliferative activity assay GI50 = 2.74 μM 26318067
U937 Cytotoxicity assay GI50 = 2.74 μM 24878193
MCF7 Growth inhibition assay IC50 = 2.78 μM 29102175
MDA-MB-231 Antiproliferative activity assay IC50 = 2.8 μM 29202403
HepG2 Antiproliferative activity assay IC50 = 2.84 μM 28242553
U937 Growth inhibition assay GI50 = 2.85 μM 22014755
A549 Cytotoxicity assay IC50 = 2.92 μM 28927801
A549 Cytotoxicity assay IC50 = 2.92 μM 27777009
ZR75-30 Growth inhibition assay IC50 = 2.96 μM 29102175
PC3 Cytotoxicity assay IC50 = 3.03 μM 28340913
MDA-MB-231 Antiproliferative activity assay IC50 = 3.08 μM 26991938
A549 Growth inhibition assay IC50 = 3.1 μM 29102175
K562 Growth inhibition assay GI50 = 3.16 μM 28088086
MOLT4 Growth inhibition assay GI50 = 3.16 μM 28088086
A549/ATCC Growth inhibition assay GI50 = 3.16 μM 28088086
RPMI8226 Growth inhibition assay TGI = 3.16 μM 28088086
SR Growth inhibition assay GI50 = 3.16 μM 28088086
HOP62 Growth inhibition assay TGI = 3.16 μM 28088086
NCI-H226 Growth inhibition assay TGI = 3.16 μM 28088086
U251 Growth inhibition assay TGI = 3.16 μM 28088086
COLO205 Growth inhibition assay TGI = 3.16 μM 28088086
M14 Growth inhibition assay TGI = 3.16 μM 28088086
HCC2998 Growth inhibition assay GI50 = 3.16 μM 28088086
SNB75 Growth inhibition assay GI50 = 3.16 μM 28088086
786-0 Growth inhibition assay GI50 = 3.16 μM 28088086
A498 Growth inhibition assay TGI = 3.16 μM 28088086
HCT15 Growth inhibition assay TGI = 3.16 μM 28088086
OVCAR3 Growth inhibition assay GI50 = 3.16 μM 28088086
OVCAR4 Growth inhibition assay GI50 = 3.16 μM 28088086
Caki1 Growth inhibition assay GI50 = 3.16 μM 28088086
SNB19 Growth inhibition assay GI50 = 3.16 μM 28088086
OVCAR5 Growth inhibition assay GI50 = 3.16 μM 28088086
DU145 Growth inhibition assay GI50 = 3.16 μM 28088086
OVCAR8 Growth inhibition assay GI50 = 3.16 μM 28088086
SN12C Growth inhibition assay TGI = 3.16 μM 28088086
MDA-MB-231 Growth inhibition assay TGI = 3.16 μM 28088086
RXF393 Growth inhibition assay GI50 = 3.16 μM 28088086
BT549 Growth inhibition assay GI50 = 3.16 μM 28088086
K562 Cytotoxicity assay GI50 = 3.16 μM 26590508
MOLT4 Cytotoxicity assay GI50 = 3.16 μM 26590508
SNB19 Cytotoxicity assay GI50 = 3.16 μM 26590508
SR Cytotoxicity assay GI50 = 3.16 μM 26590508
A549 Cytotoxicity assay GI50 = 3.16 μM 26590508
OVCAR3 Cytotoxicity assay GI50 = 3.16 μM 26590508
OVCAR4 Cytotoxicity assay GI50 = 3.16 μM 26590508
SNB75 Cytotoxicity assay GI50 = 3.16 μM 26590508
OVCAR5 Cytotoxicity assay GI50 = 3.16 μM 26590508
DU145 Cytotoxicity assay GI50 = 3.16 μM 26590508
786-0 Cytotoxicity assay GI50 = 3.16 μM 26590508
BT549 Cytotoxicity assay GI50 = 3.16 μM 26590508
ACHN Cytotoxicity assay GI50 = 3.16 μM 26590508
Caki1 Cytotoxicity assay GI50 = 3.16 μM 26590508
786-0 Antiproliferative activity assay GI50 = 3.16 μM 27017549
LOXIMVI Antiproliferative activity assay TGI = 3.16 μM 27017549
Caki1 Antiproliferative activity assay GI50 = 3.16 μM 27017549
OVCAR5 Antiproliferative activity assay GI50 = 3.16 μM 27017549
RXF393 Antiproliferative activity assay GI50 = 3.16 μM 27017549
SNB75 Antiproliferative activity assay GI50 = 3.16 μM 27017549
OVCAR3 Antiproliferative activity assay GI50 = 3.16 μM 27017549
SNB19 Antiproliferative activity assay GI50 = 3.16 μM 27017549
SK-MEL-5 Antiproliferative activity assay TGI = 3.16 μM 27017549
OVCAR4 Antiproliferative activity assay GI50 = 3.16 μM 27017549
SK-MEL-2 Antiproliferative activity assay TGI = 3.16 μM 27017549
BT549 Antiproliferative activity assay GI50 = 3.16 μM 27017549
MOLT4 Antiproliferative activity assay GI50 = 3.16 μM 27017549
K562 Antiproliferative activity assay GI50 = 3.16 μM 27017549
HCC2998 Antiproliferative activity assay GI50 = 3.16 μM 27017549
HCC2998 Antiproliferative activity assay TGI = 3.16 μM 27017549
A549/ATCC Antiproliferative activity assay GI50 = 3.16 μM 27017549
DU145 Antiproliferative activity assay GI50 = 3.16 μM 27017549
SR Antiproliferative activity assay GI50 = 3.16 μM 27017549
MCF7 Cytotoxicity assay IC50 = 3.18 μM 28927801
PC3 Cytotoxicity assay IC50 = 3.18 μM 28927801
MCF7 Cytotoxicity assay IC50 = 3.18 μM 27777009
A549 Antiproliferative activity assay IC50 = 3.19 μM 25778995
PC3 Cytotoxicity assay IC50 = 3.24 μM 27777009
HeLa Function assay IC50 = 3.3 μM 15225706
HeLa Function assay IC50 = 3.3 μM 15225706
LoVo Cytotoxicity assay IC50 = 3.3 μM 23454017
A375 Antiproliferative activity assay IC50 = 3.36 μM 29602674
HT-29 Antiproliferative activity assay IC50 = 3.37 μM 26991938
FLT3 gene-deficient U937 Antiproliferative activity assay GI50 = 3.4 μM 21708468
FLT3 negative U937 Cytotoxicity assay GI50 = 3.4 μM 23618709
U937 Cytotoxicity assay GI50 = 3.4 μM 26081023
A375P Antiproliferative activity assay GI50 = 3.4 μM 29459144
ACHN Cytotoxicity assay IC50 = 3.4 μM 29517908
ACHN Cytotoxicity assay IC50 = 3.4 μM 29297688
HepG2 Function assay IC50 = 3.4 μM 26071861
A375P Cytotoxicity assay GI50 = 3.4 μM 24878193
HepG2 Cytotoxicity assay IC50 = 3.44 μM 28927801
HepG2 Cytotoxicity assay IC50 = 3.44 μM 27777009
ACHN Cytotoxicity assay IC50 = 3.5 μM 29786436
HepG2 Antiproliferative activity assay IC50 = 3.5 μM 25462265
HT-29 Cytotoxicity assay IC50 = 3.61 μM 24826815
HT-29 Antiproliferative activity assay IC50 = 3.61 μM 30216849
HT-29 Cytotoxicity assay IC50 = 3.61 μM 25086238
HT-29 Cytotoxicity assay IC50 = 3.61 μM 25440879
MCF7 Anticancer activity assay IC50 = 3.64 μM 29549841
Sf9 Function assay IC50 = 3.8 μM 21708468
Sf9 Function assay IC50 = 3.8 μM 23618709
Sf9 Function assay IC50 = 3.8 μM 26081023
A2058 Cytotoxicity assay IC50 = 3.8 μM 22708987
NCI-H460 Cytotoxicity assay IC50 = 3.9 μM 23454017
SK-MEL-30 Cytotoxicity assay IC50 = 3.9 μM 29461827
HT-29 Anticancer activity assay IC50 = 3.97 μM 29549841
SF268 Growth inhibition assay TGI = 3.98 μM 28088086
SNB75 Growth inhibition assay TGI = 3.98 μM 28088086
OVCAR3 Growth inhibition assay TGI = 3.98 μM 28088086
SNB19 Growth inhibition assay TGI = 3.98 μM 28088086
Hs 578T Growth inhibition assay TGI = 3.98 μM 28088086
TK10 Growth inhibition assay GI50 = 3.98 μM 28088086
BT549 Growth inhibition assay TGI = 3.98 μM 28088086
Caki1 Antiproliferative activity assay TGI = 3.98 μM 27017549
TK10 Antiproliferative activity assay GI50 = 3.98 μM 27017549
MDA-MB-435 Antiproliferative activity assay TGI = 3.98 μM 27017549
HCT116 Antiproliferative activity assay TGI = 3.98 μM 27017549
MDA-MB-231 Antiproliferative activity assay TGI = 3.98 μM 27017549
HepG2 Cytotoxicity assay IC50 = 4 μM 23454017
HT-29 Cytotoxicity assay IC50 = 4 μM 23454017
A549 Cytotoxicity assay IC50 = 4 μM 23454017
HuH7 Cytotoxicity assay GI50 = 4 μM 23726028
PC3 Antiproliferative activity assay IC50 = 4.13 μM 25778995
HeLa Cytotoxicity assay IC50 = 4.163 μM 23362959
MDA-MB-436 Antiproliferative activity assay IC50 = 4.2 μM 29202403
MCF7 Cytotoxicity assay IC50 = 4.21 μM 27043268
MCF7 Cytotoxicity assay IC50 = 4.21 μM 28340913
LOXIMVI Antiproliferative activity assay IC50 = 4.25 μM 25778995
OVCAR4 Cytotoxicity assay TGI = 4.31 μM 26590508
WM1361 Antiproliferative activity assay GI50 = 4.345 μM 20148563
WM266.4 Growth inhibition assay GI50 = 4.5 μM 20199087
HepG2 Cytotoxicity assay GI50 = 4.5 μM 23726028
A549 Antiproliferative activity assay IC50 = 4.5 μM 23260578
LS174T Function assay IC50 = 4.52 μM 29266937
8505C Antiproliferative activity assay IC50 = 4.7 μM 29032031
OVCAR8 Cytotoxicity assay TGI = 4.73 μM 26590508
MDA-MB-231 Cytotoxicity assay IC50 = 4.77 μM 20435479
B16-F1 Antiproliferative activity assay IC50 = 4.9 μM 18477505
WM164 Antiproliferative activity assay IC50 = 4.9 μM 17561392
B16-F1 Antiproliferative activity assay IC50 = 4.9 μM 20056548
MDA-MB-468 Cytotoxicity assay IC50 = 4.9 μM 26159483
786-O Cytotoxicity assay IC50 = 4.9 μM 29517908
786-O Cytotoxicity assay IC50 = 4.9 μM 29297688
WM266.4 Antiproliferative activity assay GI50 = 4.933 μM 20148563
WM266.4 Growth inhibition assay IC50 = 5 μM 19323560
WM164 Antiproliferative activity assay IC50 = 5 μM 20056548
HepG2 Antiproliferative activity assay IC50 = 5 μM 23260578
HepG2 Antiproliferative activity assay IC50 = 5 μM 23932071
NCI-H23 Growth inhibition assay TGI = 5.01 μM 28088086
NCI-H322M Growth inhibition assay TGI = 5.01 μM 28088086
NCI-H460 Growth inhibition assay TGI = 5.01 μM 28088086
NCI-H522 Growth inhibition assay TGI = 5.01 μM 28088086
HT-29 Growth inhibition assay TGI = 5.01 μM 28088086
CCRF-CEM Growth inhibition assay TGI = 5.01 μM 28088086
SW620 Growth inhibition assay TGI = 5.01 μM 28088086
HOP92 Growth inhibition assay TGI = 5.01 μM 28088086
786-0 Growth inhibition assay TGI = 5.01 μM 28088086
MDA-MB-435 Growth inhibition assay TGI = 5.01 μM 28088086
PC3 Growth inhibition assay TGI = 5.01 μM 28088086
UACC257 Growth inhibition assay TGI = 5.01 μM 28088086
SKOV3 Growth inhibition assay TGI = 5.01 μM 28088086
RXF393 Growth inhibition assay TGI = 5.01 μM 28088086
T47D Growth inhibition assay TGI = 5.01 μM 28088086
MDA-MB-468 Growth inhibition assay TGI = 5.01 μM 28088086
UACC62 Antiproliferative activity assay TGI = 5.01 μM 27017549
UACC257 Antiproliferative activity assay TGI = 5.01 μM 27017549
SK-MEL-5 Antiproliferative activity assay LC50 = 5.01 μM 27017549
M14 Antiproliferative activity assay TGI = 5.01 μM 27017549
NCI-H23 Antiproliferative activity assay TGI = 5.01 μM 27017549
SF295 Antiproliferative activity assay TGI = 5.01 μM 27017549
HOP92 Antiproliferative activity assay TGI = 5.01 μM 27017549
BT549 Antiproliferative activity assay TGI = 5.01 μM 27017549
MDA-MB-231 Cytotoxicity assay IC50 = 5.1 μM 26159483
DU145 Cytotoxicity assay IC50 = 5.1 μM 22708987
A549 Cytotoxicity assay IC50 = 5.21 μM 20181414
HeLa Cytotoxicity assay IC50 = 5.23 μM 26342867
786-O Cytotoxicity assay IC50 = 5.3 μM 29786436
HCT116 Antiproliferative activity assay GI50 = 5.4 μM 15225706
A375 Antiproliferative activity assay IC50 = 5.4 μM 18477505
SK-MEL-188 Antiproliferative activity assay IC50 = 5.4 μM 17561392
A375 Antiproliferative activity assay IC50 = 5.4 μM 20056548
MCF7 Cytotoxicity assay IC50 = 5.5 μM 26159483
A375 Antiproliferative activity assay IC50 = 5.58 μM 19464887
A375P Cytotoxicity assay IC50 = 5.58 μM 20797858
A375P Antiproliferative activity assay GI50 = 5.58 μM 21353571
A375P Growth inhibition assay GI50 = 5.58 μM 22014755
A375P Growth inhibition assay GI50 = 5.58 μM 20149658
A375P Antiproliferative activity assay GI50 = 5.58 μM 20466542
A375P Antiproliferative activity assay IC50 = 5.6 μM 19857963
A375P Antiproliferative activity assay IC50 = 5.6 μM 21592628
A375P Antiproliferative activity assay IC50 = 5.6 μM 22033063
A375P Cytotoxicity assay IC50 = 5.6 μM 19897366
A375P Antiproliferative activity assay IC50 = 5.6 μM 22647720
HCT116 Cytotoxicity assay IC50 = 5.65 μM 24215818
SH-SY5Y Antiproliferative activity assay IC50 = 5.73 μM 24315192
HepG2 Cytotoxicity assay IC50 = 5.74 μM 25461318
Bel7402 Cytotoxicity assay IC50 = 5.8 μM 23454017
HT-29 Cytotoxicity assay IC50 = 5.9 μM 28865276
melanoma Growth inhibition assay IC50 = 6.1 μM 16392826
K562 Antiproliferative activity assay GI50 = 6.2 μM 21708468
HepG2 Cytotoxicity assay IC50 = 6.2 μM 28865276
A549 Anticancer activity assay IC50 = 6.21 μM 29549841
SMMC7721 Antiproliferative activity assay IC50 = 6.23 μM 22721924
HepG2 Antiproliferative activity assay IC50 = 6.3 μM 23932071
SF295 Growth inhibition assay TGI = 6.31 μM 28088086
SK-MEL-2 Growth inhibition assay TGI = 6.31 μM 28088086
OVCAR5 Growth inhibition assay TGI = 6.31 μM 28088086
UO31 Growth inhibition assay TGI = 6.31 μM 28088086
A498 Antiproliferative activity assay TGI = 6.31 μM 27017549
MALME-3M Antiproliferative activity assay TGI = 6.31 μM 27017549
U251 Antiproliferative activity assay TGI = 6.31 μM 27017549
SK-MEL-2 Antiproliferative activity assay LC50 = 6.31 μM 27017549
RPMI8226 Antiproliferative activity assay TGI = 6.31 μM 27017549
HCC2998 Antiproliferative activity assay LC50 = 6.31 μM 27017549
NCI-H522 Antiproliferative activity assay TGI = 6.31 μM 27017549
HUVEC Antiproliferative activity assay IC50 = 6.42 μM 23644219
A549 Cytotoxicity assay IC50 = 6.53 μM 27043268
A549 Cytotoxicity assay IC50 = 6.53 μM 28340913
LoVo Antiproliferative activity assay IC50 = 6.56 μM 24315192
A375 Function assay IC50 = 6.599 μM 21807507
HCT116 Function assay GI50 = 6.6 μM 15225706
HepG2 Cytotoxicity assay IC50 = 6.7 μM 26159483
BCPAP Antiproliferative activity assay IC50 = 6.7 μM 29032031
A549 Cytotoxicity assay IC50 = 6.7 μM 28865276
PC3 Cytotoxicity assay IC50 = 6.8 μM 23021967
SGC7901 Cytotoxicity assay IC50 = 6.9 μM 23454017
OS-RC2 Cytotoxicity assay IC50 = 7 μM 29517908
OS-RC2 Cytotoxicity assay IC50 = 7 μM 29297688
COLO205 Antiproliferative activity human IC50 = 7.04 μM 28242553
rhabdomyosarcoma Cytotoxicity activity against human CC50 = 7.05 μM 27288186
HuH7 Cytotoxicity assay IC50 = 7.1 μM 26159483
MDA-MB-231 Antiproliferative activity assay IC50 = 7.18 μM 22721924
FLT3-negative K562 Cytotoxicity assay GI50 = 7.3 μM 23618709
K562 Function assay GI50 = 7.3 μM 26081023
K562 Function assay GI50 = 7.3 μM 26081023
MCF7 Antiproliferative activity assay IC50 = 7.33 μM 23644219
A549 Cytotoxicity assay TGI = 7.36 μM 26590508
WI38 Cytotoxicity assay IC50 = 7.54 μM 24826815
A375 Cytotoxicity assay IC50 = 7.56 μM 24215818
MDA-MB-231 Cytotoxicity assay IC50 = 7.62 μM 20181414
786-0 Cytotoxicity assay TGI = 7.62 μM 26590508
HS27 Antiproliferative activity assay IC50 = 7.8 μM 19857963
HS27 Cytotoxicity assay IC50 = 7.8 μM 19897366
HCT116 Cytotoxicity assay IC50 = 7.8 μM 22483592
HS27 Antiproliferative activity assay IC50 = 7.85 μM 19464887
HS27 Antiproliferative activity assay GI50 = 7.85 μM 21353571
A549/ATCC Growth inhibition assay TGI = 7.94 μM 28088086
DU145 Growth inhibition assay TGI = 7.94 μM 28088086
NCI/ADR-RES Growth inhibition assay TGI = 7.94 μM 28088086
MCF7 Growth inhibition assay TGI = 7.94 μM 28088086
PC3 Antiproliferative activity assay TGI = 7.94 μM 27017549
UO31 Antiproliferative activity assay TGI = 7.94 μM 27017549
NCI-ADR-RES Antiproliferative activity assay TGI = 7.94 μM 27017549
LOXIMVI Antiproliferative activity assay LC50 = 7.94 μM 27017549
SK-MEL-28 Antiproliferative activity assay TGI = 7.94 μM 27017549
KM12 Antiproliferative activity assay TGI = 7.94 μM 27017549
COLO205 Antiproliferative activity assay TGI = 7.94 μM 27017549
HT-29 Antiproliferative activity assay TGI = 7.94 μM 27017549
NCI-H226 Antiproliferative activity assay TGI = 7.94 μM 27017549
HOP62 Antiproliferative activity assay TGI = 7.94 μM 27017549
T47D Antiproliferative activity assay TGI = 7.94 μM 27017549
MDA-MB-468 Antiproliferative activity assay TGI = 7.94 μM 27017549
EKVX Antiproliferative activity assay TGI = 7.94 μM 27017549
MCF7 Antiproliferative activity assay TGI = 7.94 μM 27017549
Hs 578T Antiproliferative activity assay TGI = 7.94 μM 27017549
MGC803 Antiproliferative activity assay IC50 = 7.99 μM 26560049
HCT116 Antiproliferative activity assay IC50 = 8.08 μM 24440479
PC3 Cytotoxicity assay IC50 = 8.08 μM 27043268
HCT116 Antiproliferative activity assay IC50 = 8.08 μM 23644219
WM266.4 Antiproliferative activity assay GI50 = 8.1 μM 23025996
WM266.4 Antiproliferative activity assay GI50 = 8.12 μM 22583669
Ketr3 Antiproliferative activity assay IC50 = 8.27 μM 30216849
A375 Antiproliferative activity assay IC50 = 8.27 μM 30216849
HepG2 Antiproliferative activity assay IC50 = 8.27 μM 30216849
MX1 Antiproliferative activity assay IC50 = 8.27 μM 30216849
MX1 Cytotoxicity assay IC50 = 8.27 μM 24675135
WM266.4 Growth inhibition assay GI50 = 8.3 μM 22361686
PLC/PRF/5 Cytotoxicity assay IC50 = 8.3 μM 21531053
A375 Antiproliferative activity assay IC50 = 8.33 μM 29886324
HCT116 Cytotoxicity assay IC50 = 8.41 μM 29631788
WI38 Cytotoxicity assay IC50 = 8.42 μM 26991938
HepG2 Cytotoxicity assay IC50 = 8.42 μM 27162123
HepG2 Cytotoxicity assay IC50 = 8.42 μM 23871909
HT-29 Antiproliferative activity assay IC50 = 8.44 μM 29602674
HepG2 Cytotoxicity assay IC50 = 8.67 μM 24675135
MCF7 Cytotoxicity assay IC50 = 8.83 μM 20435479
MCF7 Cytotoxicity assay IC50 = 9.12 μM 24300920
HepG2 Antiproliferative activity assay IC50 = 9.14 μM 26560049
A375 Cytotoxicity assay IC50 = 9.17 μM 24675135
MGC803 Antiproliferative activity assay IC50 = 9.2 μM 29032031
SKOV3 Cytotoxicity assay IC50 = 9.25 μM 24300920
RS4:11 Function assay GI50 = 9.3 μM 26081023
RS4:11 Cytotoxicity assay GI50 = 9.3 μM 23618709
MIAPaCa2 Antiproliferative activity assay IC50 = 9.32 μM 29032031
PANC1 Growth inhibition assay IC50 = 9.32 μM 29102175
MHCC97H Growth inhibition assay IC50 = 9.32 μM 29102175
RS4:11 Antiproliferative activity assay GI50 = 9.4 μM 21708468
Hep3B Cytotoxicity assay IC50 = 9.4 μM 28865276
LoVo Growth inhibition assay IC50 = 9.47 μM 29102175
SMMC7721 Antiproliferative activity assay IC50 = 9.96 μM 25637123
MCF7 Cytotoxicity assay TGI = 9.97 μM 26590508
IGROV1 Growth inhibition assay TGI = 10 μM 28088086
ACHN Growth inhibition assay TGI = 10 μM 28088086
TK10 Growth inhibition assay TGI = 10 μM 28088086
786-0 Antiproliferative activity assay TGI = 10 μM 27017549
SN12C Antiproliferative activity assay TGI = 10 μM 27017549
Caki1 Antiproliferative activity assay LC50 = 10 μM 27017549
TK10 Antiproliferative activity assay TGI = 10 μM 27017549
RXF393 Antiproliferative activity assay TGI = 10 μM 27017549
OVCAR8 Antiproliferative activity assay TGI = 10 μM 27017549
SNB75 Antiproliferative activity assay TGI = 10 μM 27017549
NCI-H322M Antiproliferative activity assay TGI = 10 μM 27017549
MDA-MB-435 Antiproliferative activity assay LC50 = 10 μM 27017549
SF539 Antiproliferative activity assay TGI = 10 μM 27017549
SF268 Antiproliferative activity assay TGI = 10 μM 27017549
NCI-H460 Antiproliferative activity assay TGI = 10 μM 27017549
DU145 Antiproliferative activity assay TGI = 10 μM 27017549
K1 Antiproliferative activity assay IC50 = 10.2 μM 29032031
Bel7402 Cytotoxicity assay IC50 = 10.26 μM 21504204
Bel7402 Growth inhibition assay IC50 = 10.31 μM 29102175
OVCAR3 Cytotoxicity assay TGI = 10.32 μM 26590508
SGC7901 Cytotoxicity assay IC50 = 10.37 μM 20435479
SNB75 Cytotoxicity assay TGI = 10.42 μM 26590508
A431 Antiproliferative activity assay IC50 = 10.46 μM 29032031
SMMC7721 Antiproliferative activity assay IC50 = 10.61 μM 29032031
GES-1 Cytotoxicity assay IC50 = 10.68 μM 27162123
H460 Cytotoxicity assay IC50 = 10.8 μM 24300920
BGC823 Antiproliferative activity assay IC50 = 10.91 μM 22721924
Hep3B Cytotoxicity assay IC50 = 11.2 μM 28342400
MCF7 Cytotoxicity assay IC50 = 11.34 μM 27162123
MCF7 Cytotoxicity assay IC50 = 11.34 μM 23871909
SK-MEL-2 Antiproliferative activity human IC50 = 11.35 μM 28242553
HepG2 Cytotoxicity assay IC50 = 11.49 μM 21504204
A375P Antiproliferative activity assay IC50 = 11.5 μM 22014559
SGC7901 Cytotoxicity assay IC50 = 11.5 μM 24300920
HeLa Antiproliferative activity assay IC50 = 12.01 μM 29103873
PANC1 Cytotoxicity assay IC50 = 12.3 μM 24300920
HepG2 Antiproliferative activity assay IC50 = 12.54 μM 29032031
A549 Antiproliferative activity assay IC50 = 12.54 μM 23644219
Caki1 Growth inhibition assay TGI = 12.59 μM 28088086
OVCAR8 Growth inhibition assay TGI = 12.59 μM 28088086
SKOV3 Antiproliferative activity assay TGI = 12.6 μM 27017549
ACHN Antiproliferative activity assay TGI = 12.6 μM 27017549
OVCAR3 Antiproliferative activity assay TGI = 12.6 μM 27017549
OVCAR4 Antiproliferative activity assay TGI = 12.6 μM 27017549
HCT15 Antiproliferative activity assay TGI = 12.6 μM 27017549
SW620 Antiproliferative activity assay TGI = 12.6 μM 27017549
A549/ATCC Antiproliferative activity assay TGI = 12.6 μM 27017549
MDA-MB-468 Cytotoxicity assay TGI = 13.09 μM 26590508
SK-MEL-28 Cytotoxicity assay TGI = 13.39 μM 26590508
A549 Antiproliferative activity assay IC50 = 13.64 μM 26560049
A375 Antiproliferative activity human IC50 = 13.64 μM 28242553
A375 Antiproliferative activity assay IC50 = 13.64 μM 25462267
K562 Antiproliferative activity assay IC50 = 13.85 μM 23644219
Hep3B Cytotoxicity assay IC50 = 14.08 μM 21504204
T47D Cytotoxicity assay TGI = 14.38 μM 26590508
NCI-H226 Cytotoxicity assay TGI = 14.42 μM 26590508
MDA-MB-231 Antiproliferative activity assay IC50 = 14.62 μM 24440479
MDA-MB-231 Antiproliferative activity assay IC50 = 14.62 μM 23644219
NCI-H522 Cytotoxicity assay TGI = 14.82 μM 26590508
SK-MEL-2 Cytotoxicity assay TGI = 14.85 μM 26590508
OS-RC2 Cytotoxicity assay IC50 = 15 μM 29786436
HepG2 Antiproliferative activity assay IC50 = 15 μM 29103873
fibroblast Antiproliferative activity assay IC50 = 15.1 μM 18477505
HT-29 Cytotoxicity assay IC50 = 15.2 μM 24675135
U87MG Cytotoxicity assay IC50 = 15.57 μM 24826815
BT549 Antiproliferative activity assay LC50 = 15.8 μM 27017549
GES-1 Cytotoxicity assay IC50 = 15.8 μM 23871909
SNB19 Antiproliferative activity assay TGI = 15.85 μM 27017549
IGROV1 Antiproliferative activity assay TGI = 15.9 μM 27017549
HCT116 Antiproliferative activity assay LC50 = 15.9 μM 27017549
OS-RC2 Cytotoxicity assay IC50 = 16 μM 23454017
A375 Cytotoxicity assay IC50 = 16.24 μM 25461318
SKOV3 Cytotoxicity assay TGI = 16.36 μM 26590508
WM1361 Antiproliferative activity assay IC50 = 16.44 μM 29602674
MKN28 Antiproliferative activity assay IC50 = 17 μM 29032031
SMMC7721 Cytotoxicity assay IC50 = 17.3 μM 21504204
UACC257 Cytotoxicity assay TGI = 17.33 μM 26590508
EAhy926 Antiangiogenic activity assay IC50 = 18.52 μM 29032031
SMMC7721 Cytotoxicity assay IC50 = 18.7 μM 24300920
Ketr3 Cytotoxicity assay IC50 = 18.8 μM 24675135
NCI-H522 Cytotoxicity assay IC50 = 19.26 μM 25461318
A549 Cytotoxicity assay IC50 = 19.54 μM 27162123
SH-SY5Y Cytotoxicity assay IC50 = 19.54 μM 23871909
MGC803 Antiproliferative activity assay IC50 = 19.92 μM 29103873
EKVX Growth inhibition assay TGI = 19.95 μM 28088086
OVCAR5 Antiproliferative activity assay TGI = 20 μM 27017549
UACC62 Antiproliferative activity assay LC50 = 20 μM 27017549
UACC257 Antiproliferative activity assay LC50 = 20 μM 27017549
MDA-MB-231 Antiproliferative activity assay LC50 = 20 μM 27017549
U87 Cytotoxicity assay IC50 = 21.07 μM 20435479
EJ Cytotoxicity assay IC50 = 22.9 μM 24300920
HCT116 Antiproliferative activity assay IC50 = 23.31 μM 29602674
HOP62 Cytotoxicity assay TGI = 23.55 μM 26590508
MDA-MB-231 Cytotoxicity assay TGI = 23.93 μM 26590508
PC3 Antiproliferative activity assay IC50 = 24.2 μM 24440479
PC3 Antiproliferative activity assay IC50 = 24.2 μM 23644219
EAhy926 Antiproliferative activity assay IC50 = 24.36 μM 28068599
EAhy926 Anti-angiogenic activity in human IC50 = 24.36 μM 29102175
U251 Cytotoxicity assay IC50 = 24.71 μM 20435479
NIH/3T3 Antiproliferative activity assay IC50 = 24.75 μM 21592628
NIH/3T3 Antiproliferative activity assay IC50 = 24.75 μM 22647720
DU145 Cytotoxicity assay IC50 = 24.91 μM 27162123
DU145 Cytotoxicity assay IC50 = 24.91 μM 23871909
U251 Antiproliferative activity assay LC50 = 25.1 μM 27017549
M14 Antiproliferative activity assay LC50 = 25.1 μM 27017549
NCI-H522 Antiproliferative activity assay LC50 = 25.1 μM 27017549
OVCAR4 Growth inhibition assay TGI = 25.12 μM 28088086
SH-SY5Y Cytotoxicity assay IC50 = 27.71 μM 27162123
A549 Cytotoxicity assay IC50 = 27.71 μM 23871909
PLC/PRF/5 Cytotoxicity assay IC50 = 29.9 μM 28109948
SK-MEL-5 Cytotoxicity assay TGI = 31.26 μM 26590508
A498 Antiproliferative activity assay LC50 = 31.6 μM 27017549
SK-MEL-28 Antiproliferative activity assay LC50 = 31.6 μM 27017549
KM12 Antiproliferative activity assay LC50 = 31.6 μM 27017549
COLO205 Antiproliferative activity assay LC50 = 31.6 μM 27017549
NCI-H226 Antiproliferative activity assay LC50 = 31.6 μM 27017549
SF295 Antiproliferative activity assay LC50 = 31.6 μM 27017549
HOP62 Antiproliferative activity assay LC50 = 31.6 μM 27017549
T47D Antiproliferative activity assay LC50 = 31.6 μM 27017549
MHCC97L Cytotoxicity assay IC50 = 34.41 μM 28109948
MDA-MB-231 Antiproliferative activity assay IC50 = 35 μM 24315192
MDA-MB-231 Cytotoxicity assay IC50 = 36 μM 22483592
B16-BL6 Cytotoxicity assay IC50 = 36.48 μM 29631788
UO31 Antiproliferative activity assay LC50 = 39.8 μM 27017549
SN12C Antiproliferative activity assay LC50 = 39.8 μM 27017549
RXF393 Antiproliferative activity assay LC50 = 39.8 μM 27017549
SNB75 Antiproliferative activity assay LC50 = 39.8 μM 27017549
SF268 Antiproliferative activity assay LC50 = 39.8 μM 27017549
NCI-H23 Antiproliferative activity assay LC50 = 39.8 μM 27017549
HT-29 Antiproliferative activity assay LC50 = 39.8 μM 27017549
HOP92 Antiproliferative activity assay LC50 = 39.8 μM 27017549
NCI-H460 Antiproliferative activity assay LC50 = 39.8 μM 27017549
SW620 Antiproliferative activity assay LC50 = 39.8 μM 27017549
MDA-MB-468 Antiproliferative activity assay LC50 = 39.8 μM 27017549
MALME-3M Growth inhibition assay TGI = 39.81 μM 28088086
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生物活性

製品説明 Sorafenib is a multikinase inhibitor of Raf-1 and B-Raf with IC50 of 6 nM and 22 nM in cell-free assays, respectively. Sorafenib inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3 and c-KIT with IC50 of 90 nM, 20 nM, 57 nM, 59 nM and 68 nM, respectively. Sorafenib induces autophagy and apoptosis and activates ferroptosis with anti-tumor activity.
Targets
Raf-1 [1]
(Cell-free assay)		 mVEGFR2(Flk1) [1]
(Cell-free assay)		 mVEGFR3 [1]
(Cell-free assay)		 B-Raf [1]
(Cell-free assay)		 B-Raf (V599E) [1]
(Cell-free assay)		 もっとクリックする
6 nM 15 nM 20 nM 22 nM 38 nM
In Vitro
In vitro Sorafenib inhibits both wild-type and V599E mutant B-Raf activity with IC50 of 22 nM and 38 nM, respectively. Sorafenib also potently inhibits mVEGFR2 (Flk-1), mVEGFR3, mPDGFRβ, Flt3, and c-Kit with IC50 of 15 nM, 20 nM, 57 nM, 58 nM, and 68 nM, respectively. Sorafenib weakly inhibits FGFR-1 with IC50 of 580 nM. Sorafenib tosylate is not active against ERK-1, MEK-1, EGFR, HER-2, IGFR-1, c-Met, PKB, PKA, cdk1/cyclinB, PKCα, PKCγ, and pim-1. Sorafenib markedly inhibits VEGFR2 phosphorylation in NIH 3T3 cells with IC50 of 30 nM, and Flt-3 phosphorylation in HEK-293 cells with IC50 of 20 nM. Sorafenib potently blocks MEK 1/2 and ERK 1/2 phosphorylation in most cell lines but not in A549 or H460 cells, while having no effect on inhibition of the PKB pathway. Sorafenib inhibits the proliferation of HAoSMC and MDA-MB-231 cells with IC50 of 0.28 μM and 2.6 μM, respectively. [1] In addition to inhibition of the RAF/MEK/ERK signaling pathway, Sorafenib significantly inhibits the phosphorylation of eIF4E and down-regulates Mcl-1 levels in hepatocellular carcinoma (HCC) cells in a MEK/ERK-independent manner. Sorafenib inhibits the proliferation of PLC/PRF/5 and HepG2 cells with IC50 of 6.3 μM and 4.5 μM, respectively, and leads to the significant induction of apoptosis. [2]
Kinase Assay Biochemical assays
Recombinant baculoviruses expressing Raf-1 (residues 305–648) and B-Raf (residues 409–765) are purified as fusion proteins. Full-length human MEK-1 is generated by PCR and purified as a fusion protein from Escherichia coli lysates. Sorafenib tosylate is added to a mixture of Raf-1 (80 ng), or B-Raf (80 ng) with MEK-1 (1 μg) in assay buffer [20 mM Tris (pH 8.2), 100 mM NaCl, 5 mM MgCl2, and 0.15% β-mercaptoethanol] at a final concentration of 1% DMSO. The Raf kinase assay (final volume of 50 μL) is initiated by adding 25 μL of 10 μM γ[33P]ATP (400 Ci/mol) and incubated at 32 °C for 25 minutes. Phosphorylated MEK-1 is harvested by filtration onto a phosphocellulose mat, and 1% phosphoric acid is used to wash away unbound radioactivity. After drying by microwave heating, a β-plate counter is used to quantify filter-bound radioactivity. Human VEGFR2 (KDR) kinase domain is expressed and purified from Sf9 lysates. Time-resolved fluorescence energy transfer assays for VEGFR2 are performed in 96-well opaque plates in the time-resolved fluorescence energy transfer format. Final reaction conditions are as follows: 1 to 10 μM ATP, 25 nM poly GT-biotin, 2 nM Europium-labeled phospho (p)-Tyr antibody (PY20), 10 nM APC, 1 to 7 nM cytoplasmic kinase domain in final concentrations of 1% DMSO, 50 mM HEPES (pH 7.5), 10 mM MgCl2, 0.1 mM EDTA, 0.015% Brij-35, 0.1 mg/mL BSA, and 0.1% β-mercaptoethanol. Reaction volumes are 100 μL and are initiated by addition of enzyme. Plates are read at both 615 and 665 nM on a Perkin-Elmer VictorV Multilabel counter at ~1.5 to 2.0 hours after reaction initiation. Signal is calculated as a ratio: (665 nm/615 nM) × 10,000 for each well. For IC50 generation, Sorafenib tosylate is added before the enzyme initiation. A 50-fold stock plate is made with Sorafenib tosylate serially diluted 1:3 in a 50% DMSO/50% distilled water solution. Final Sorafenib tosylate concentrations range from 10 μM to 4.56 nM in 1% DMSO.
細胞実験 細胞株 MDA-MB-231, and HAoSMC
濃度 Dissolved in DMSO, final concentrations ~10 μM
反応時間 72 hours
実験の流れ

Cells are exposed to increasing concentrations of Sorafenib tosylate for 72 hours. Cell number is quantitated using the Cell TiterGlo ATP Luminescent assay kit. This assay measures the number of viable cells per well by measurement of luminescent signal based on amount of cellular ATP.
実験結果図 Methods Biomarkers 結果図 PMID
Western blot LC3-I / LC-3II / ATG5 p-STAT3 / STAT3 / Mcl-1 β-catenin / Survivin / Mcl-1 / PTMA pERK / ERK p-PKM2(y105) / PMK2 / Caspase-9 RET(pY1016) / VEGFR2(pY1214) / MEK1(pT292) / ERK(pY204) Cyclin D1 23392173
Growth inhibition assay Cell viability 26039995
Immunofluorescence p65 cytochrome c 22286758
ELISA TGF-beta / CD206 Caspase-9 / Caspase-3 26158762
In Vivo
In Vivo Oral administration of Sorafenib (~60 mg/kg) demonstrates broad spectrum, dose-dependent anti-tumor activity against a variety of human tumor xenograft models including MDA-MB-231, Colo-205, HT-29, DLD-1, NCI-H460, and A549, with no evidence of toxicity. In association with the anti-tumor efficacy, Sorafenib treatment potently inhibits MEK 1/2 phosphorylation and pERK 1/2 levels in HT-29 and MDA-MB-231 xenografts but not in Colo-205 xenografts, and significantly suppresses tumor microvessel area (MVA) and microvessel density (MVD) in MDA MB-231, HT-29 and Colo-205 tumor xenografts. [1] Sorafenib treatment produces dose-dependent growth inhibition of PLC/PRF/5 tumor xenografts in SCID mice with TGIs of 49% and 78% at 10 mg/kg and 30 mg/kg, respectively, consistent with the inhibition of ERK and eIF4E phosphorylation, reduction of the microvessel area, and induction of tumor cell apoptosis. [2] Sorafenib sensitizes bax-/- cells to TRAIL in a dose-dependent manner, through a mechanism involving down-regulating NF-κB mediated Mcl-1 and cIAP2 expression. Combining Sorafenib (30-60 mg/kg) with TRAIL (5 mg/kg) show dramatic efficacy in TRAIL-resistant HCT116 bax-/- and HT29 tumor xenografts. [3]
動物実験 動物モデル Female NCr-nu/nu mice implanted s.c. with MDA-MB-231, Colo-205, HT-29, H460, or A549 cells
投与量 ~60 mg/kg
投与経路 Orally once daily
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05068752 Recruiting
Pancreas Cancer
HonorHealth Research Institute|Bayer|Genentech Inc.
 October 28 2021 Phase 2
NCT04763408 Active not recruiting
Carcinoma Hepatocellular
Eisai Inc.
 April 9 2021 --

化学情報

分子量 464.82 化学式

C21H16ClF3N4O3
CAS No. 284461-73-0 SDF Download Sorafenib SDFをダウンロードする
Smiles CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F
保管

In vitro
Batch:

DMSO : 93 mg/mL ( (200.07 mM)； 吸湿したDMSOは溶解度を減少させます。新しいDMSOをご使用ください。)

Water : Insoluble

Ethanol : Insoluble

モル濃度計算器

in vivo
Batch:

Add solvents to the product individually and in order.

投与溶液組成計算機

実験計算

モル濃度計算器

質量 濃度 体積 分子量

投与溶液組成計算機(クリア溶液)

ステップ１：実験データを入力してください。（実験操作によるロスを考慮し、動物数を1匹分多くして計算・調製することを推奨します）

mg/kg g μL 匹

ステップ２：投与溶媒の組成を入力してください。（ロット毎に適した溶解組成が異なる場合があります。詳細については弊社までお問い合わせください）

% DMSO % % Tween 80 % ddH2O
%DMSO %

計算結果：

投与溶媒濃度： mg/ml;

DMSOストック溶液調製方法： mg 試薬を μL DMSOに溶解する（濃度 mg/mL, 注：濃度が当該ロットのDMSO溶解度を超える場合はご連絡ください。 )

投与溶媒調製方法：Take μL DMSOストック溶液に μL PEG300，を加え、完全溶解後μL Tween 80，を加えて完全溶解させた後 μL ddH2O，を加え完全に溶解させます。

投与溶媒調製方法：μL DMSOストック溶液に μL Corn oil，を加え、完全溶解。

注意：１.ストック溶液に沈殿、混濁などがないことをご確認ください；
２.順番通りに溶剤を加えてください。次のステップに進む前に溶液に沈殿、混濁などがないことを確認してから加えてください。ボルテックス、ソニケーション、水浴加熱など物理的な方法で溶解を早めることは可能です。

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Handling Instructions

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