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| 製品コード | 製品名称 | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
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| S7534 | BAPTA-AM | BAPTA-AM is a selective, membrane-permeable calcium chelator. |
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| S5259 | β-Nicotinamide Mononucleotide | Nicotinamide mononucleotide (β-NM, NMN), one of the key precursors of NAD+ and products of the NAMPT reaction , is converted to NAD+ by nicotinamide mononucleotide adenylyltransferase. | ||
| S1732 | Mitotane | Mitotane (NCI-C04933), is an antineoplastic medication used in the treatment of adrenocortical carcinoma. | ||
| S1985 | ATP disodium | ATP disodium is a disodium salt form of adenosine-triphosphate which is a multifunctional nucleoside triphosphate. | ||
| S2610 | Lonidamine | Lonidamine is an orally administered small molecule hexokinase inactivator. | ||
| A2116 | Rat IgG2b isotype control-InVivo | Rat IgG2b isotype control-InVivo monoclonal antibody (Clone:LTF-2) reacts with keyhole limpet hemocyanin (KLH). Because KLH is not expressed by mammals this antibody is ideal for use as an isotype-matched control for rat IgG2b antibodies in most in vivo and in vitro applications. |
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| S5939 | Bendamustine | Bendamustine is a nitrogen mustard drug used in the treatment of chronic lymphocytic leukemia (CLL), multiple myeloma, and non-Hodgkin's lymphoma. | ||
| S4067 | Deferiprone | Deferiprone (CP20) is a chelating agent with an affinity for ferric ion (iron III)，binds with ferric ions to form neutral 3:1 (deferiprone:iron) complexes that are stable over a wide range of pH values. | ||
| E1249 | Blebbistatin | Blebbistatin is a selective inhibitor of non-muscle myosin II (NMII). It also potently inhibits several striated muscle myosins as well as vertebrate nonmuscle myosin IIA and IIB with IC50 values ranging from 0.5 to 5 μM. It promotes directional migration of corneal endothelial cells (CECs) and accelerates wound healing, and better preserves cell junctional integrity and barrier function. | ||
| S6827 | Methyl-β-cyclodextrin (MβCD) | Methyl-β-cyclodextrin (MβCD) is a cholesterol-removing agent mainly used for lipid raft disruption. Methyl-β-cyclodextrin induces caspase-dependent apoptosis in PEL cells and inhibits the growth and invasion of PEL cells without apparent adverse effects, suggesting the potential effective antitumor activities. | ||
| S5651 | Dexrazoxane | Dexrazoxane (ICRF-187) is an anticancer drug able to block mitosis and to arrest dividing cells. It is an iron chelator and provides cardioprotection against anthracycline toxicity. | ||
| S2553 | 5-Aminolevulinic acid HCl | 5-Aminolevulinic Acid HCl(5-ALA hydrochloride) is an intermediate in the porphyrin synthesis pathway, used as a photosensitizing agent and a antineoplastic agent. | ||
| S7443 | AP-III-a4 (ENOblock) | AP-III-a4 (ENOblock) is the first nonsubstrate analogue inhibitor of enolase with IC50 of 0.576 μM. | ||
| S3000 | Carbazochrome sodium sulfonate (AC-17) | Carbazochrome sodium sulfonate (AC-17) is an antihemorrhagic for use in the treatment of hemorrhoids. | ||
| S1735 | Mesna | Mesna, a sulfhydryl compound that is used to reduce the incidence of hemorrhagic cystitis associated with certain chemotherapeutic agents. | ||
| S2370 | Ursolic Acid | Ursolic acid (NSC 167406, NSC-4060, Prunol, Urson, Malol) is a pentacyclic triterpene acid, used in cosmetics. | ||
| S7013 | Guadecitabine (SGI-110) | Guadecitabine (SGI-110, S-110) is a next-generation hypomethylating agent whose active metabolite decitabine has a longer in-vivo exposure time than intravenous decitabine. | ||
| S4298 | Amifostine trihydrate | Amifostine trihydrate(WR2721 trihydrate) is the first approved radioprotective drug, used to decrease the risk of kidney problems caused by treatment with cisplatin. | ||
| S2337 | Osthole | Osthol is an O-methylated coumarin, which is found in the plants such as Cnidium monnieri, Angelica archangelica and Angelica pubescens. |
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| S2388 | L-carnitine (Levocarnitine) | L-carnitine (Levocarnitine) is constituent of striated muscle and liver. It is used therapeutically to stimulate gastric and pancreatic secretions and in the treatment of hyperlipoproteinemias. | ||
| S2518 | NAD+ | NAD+ (β-DPN, β-NAD, β-Nicotinamide Adenine Dinucleotide,nicotinamide adenine dinucleotide) is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. | ||
| S2256 | 4-Methylumbelliferone (4-MU) | 4-Methylumbelliferone is a hyaluronic acid (HA) synthesis inhibitor with an IC50 of 0.4 mM. | ||
| S2379 | Dioscin | Dioscin (Collettiside III, Saponin) is a saponin extracted and isolated from Polygonatum Zanlanscianense Pamp, showing antitumor activities. | ||
| S3689 | Ethidium bromide | Ethidium Bromide (Homidium bromide, EtBr, EB) is an intercalating agent which resembles a DNA base pair and commonly used as a fluorescent tag (nucleic acid stain) in molecular biology laboratories for techniques such as agarose gel electrophoresis. | ||
| S9670 | Pitstop 2 | Pitstop 2 is an inhibitor of the interaction of amphiphysin with the amino terminal domain of clathrin that inhibits both clathrin-dependent endocytosis (CDE) and clathrin independent endocytosis (CIE). | ||
| S1751 | Gadodiamide Hydrate | Gadodiamide Hydrate, a nonionic Gd3+ chelate, is frequently injected i.v. into magnetic resonance imaging (MRI) to enhance contrast. |
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| S2392 | Sesamin | Sesamin (Fagarol, Fsesamin), a lignan isolated from the bark of Fagara plants and from sesame oil, exhibits various health benefits. | ||
| S2276 | Bilobalide | Bilobalide is a biologically active terpenic trilactone present in Ginkgo biloba. | ||
| S2299 | Formononetin | Formononetin (Formononetol, Biochanin B) is a phytoestrogen from the root of Astragalus membranaceus and an O-methylated isoflavone. | ||
| S2309 | Hesperidin | Hesperidin (Cirantin) is a flavanone glycoside found abundantly in citrus fruits. | ||
| S3794 | Palmitic acid | Palmitic acid (Hexadecanoic acid, Cetylic acid) is the most common saturated fatty acid found in animals, plants and microorganisms with anti-tumor activity. | ||
| S6415 | Azeliragon (TTP488) | Azeliragon (TTP488, PF-04494700) is an orally bioavailable small molecule that inhibits the receptor for advanced glycation endproducts (RAGE), which is an immunoglobulin-like cell surface receptor overexpressed in brain tissues of patients with AD. | ||
| S7446 | L-Mimosine | L-Mimosine (Leucenol) is a non-protein amino acid, and acts as an iron chelator. | ||
| S5109 | Ademetionine | Ademetionine (AdoMet, S-Adenosylmethionine, SAMe), also known as SAMe, is a specific form of the amino acid methionine known as S-adenosyl-methionine. It is essential for the formation of glutathione, a water-soluble peptide that helps the body fight free radicals. | ||
| S4368 | Carbenoxolone Sodium | Carbenoxolone, a synthetic derivative of glycyrrhetinic acid, is also used as a blocker of the enzyme 11β-hydroxysteroid dehydrogenase (11β-HSD), of pannexon membrane channels (comprising 6 subunits of pannexin) and the related innexon channels. | ||
| S8674 | GO-203 | GO-203 is a D-amino acid cell-penetrating peptide inhibitor of MUC1-C dimerization and thereby its oncogenic function. | ||
| S1749 | L-Glutamine | L-Glutamine (Gln) is one of the 20 amino acids encoded by the standard genetic code and also a major respiratory fuel and substrate for nucleic acid synthesis in mammalian intestinal cells. | ||
| S9192 | Vitexin | Vitexin (Apigenin-8-C-glucoside), an naturally occuring apigenin flavone glycoside, acts as a platelet aggregation and alpha-glucosidase inhibitor and shows antineoplastic activity. | ||
| S7589 | N6022 | N6022 is a selective, and reversible inhibitor of S-nitrosoglutathione reductase (GSNOR) with IC50 of 8 nM and Ki of 2.5 nM. Phase 1/2. | ||
| S7909 | Dp44mT | Dp44mT is a potent iron chelator, which shows selective antitumor activity. | ||
| S2280 | Chlorogenic Acid | Chlorogenic acid (NSC 407296, Heriguard) is a hydroxycinnamic acid and a member of a family of naturally occurring organic compounds. | ||
| S2210 | Sphingosine | Sphingosine (2-amino-4-trans-octadecene-1,3-diol, C18 Sphingosine) is an 18-carbon amino alcohol with an unsaturated hydrocarbon chain, which forms a primary part of sphingolipids, a class of cell membrane lipids that include sphingomyelin, an important phospholipid. | ||
| S2281 | Chrysin | Chrysin (NSC 407436) is a naturally occurring flavone chemically extracted from the blue passion flower (Passiflora caerulea). | ||
| S2398 | Coenzyme Q10 (CoQ10) | Coenzyme Q10 (ubiquinone, ubidecarenone, coenzyme Q) is a component of the electron transport chain and participates in aerobic cellular respiration.Solutions are unstable and should be fresh-prepared. |
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| S5524 | Spermine Tetrahydrochloride | Spermine (Gerontine, Neuridine, Musculamine) is a polyamine involved in cellular metabolism found in all eukaryotic cells. It is a major natural intracellular compound capable of protecting DNA from free radical attack. | ||
| S8914 | 2-NBDG | 2-NBDG, a fluorescent deoxyglucose derivative, is a a marker for detecting glucose uptake and an indicaotr of cell viability. | ||
| S6683 | D-Lin-MC3-DMA (MC3) | D-Lin-MC3-DMA (MC3, DLin-MC3-DMA) is a potent and ionizable cationic lipid. D-Lin-MC3-DMA is used for delivery of siRNA in vivo. | ||
| S2325 | Morin Hydrate | Morin hydrate (Aurantica) is a flavonoid isolated from Maclura pomifera (Osage orange), Maclura tinctoria (old fustic) and from leaves of Psidium guajava (common guava). | ||
| S6350 | Ethylenediaminetetraacetic acid | Ethylenediaminetetraacetic acid (EDTA) is a chelating agent commonly used in protein purification, to decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification and to inhibit protease activity. It can also decrease the formation of disulfide bonds and can also inhibit complement activation; protein protection in some immunoassays | ||
| S2357 | Silibinin (NSC 651520) | Silibinin (NSC 651520, Silybin, Silibinin A, Silymarin I, Flavobin), the main flavonoid extracted from the milk thistle Silybum marianum, displays hepatoprotective properties in acute and chronic liver injury. |
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| S3611 | (+)-Fangchinoline | Fangchinoline ((+)-Limacine, Tetrandrine B, Hanfangichin B) is a phytochemical that has been shown to elicit anti-cancer effects in prostate and breast cancer cell lines via inducing G1 cell cycle arrest. It has also been shown to possess neuroprotective activity. | ||
| S4578 | Tyloxapol | Tyloxapol (Triton WR1339) is a nonionic liquid polymer of the alkyl aryl polyether alcohol type, used as a surfactant to aid liquefaction, removal of mucopurulent and bronchopulmonary secretions. It also blocks plasma lipolytic activity, and thus the breakdown of triglyceride-rich lipoproteins.Tyloxapol can be used to induce animal models of Hyperlipidemia, Atherosclerosis. | ||
| S2270 | Bergenin | Bergenin (Cuscutin) is trihydroxybenzoic acid glycoside and the C-glycoside of 4-O-methyl gallic acid. | ||
| S3948 | Spermine | Spermine (4,9-Diaza-1,12-dodecanediamine) is a polyamine involved in cellular metabolism found in all eukaryotic cells. It is found in a wide variety of organisms and tissues and is an essential growth factor in some bacteria. | ||
| S0338 | NB 598 | NB-598 is a potent, competitive squalene epoxidase (SE) inhibitor. NB-598 suppresses cholesterol biosynthesis. | ||
| S6563 | DMNQ | DMNQ is a 1,4-naphthoquinone that acts as a redox-cycling agent, typically increasing intracellular superoxide and hydrogen peroxide formation. | ||
| S7758 | Trabectedin | Trabectedin (Ecteinascidin 743, ET-743) is a marine alkaloid isolated from the Caribbean tunicate Ecteinascidia turbinata with antitumour activity. Trabectedin binds to the N2 of guanine in the minor groove, causing DNA damage and affecting transcription regulation in a promoter- and gene-specific manner. |
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| S9117 | (20S)Ginsenoside Rg2 | (20S)Ginsenoside Rg2, a constituent existing in red ginseng, has been reported to exert strong inhibitory action on various cancer cells. | ||
| S4354 | Thiostrepton | Thiostrepton (Alaninamide, Bryamycin, Thiactin) is a natural cyclic oligopeptide antibiotic, derived from several strains of strepromycetes. | ||
| S9552 | Farrerol | Farrerol, an important bioactive constituent of rhododendron, exhibits broad activities such as anti-oxidative and anti-inflammatory effects. | ||
| S9819 | C75 | C75 (4-Methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid) , a more stable synthetic mimic of cerulenin, inhibits fatty-acid synthase (FAS/FASN) with an IC50 of 15.53 μM and has potential therapeutic effects in several cancer models. C75 is also a potent CPT1A activator. | ||
| S1428 | Risedronate Sodium | Risedronate (NE 58095) sodium, a nitrogen-containing bisphosphonate, inhibits osteoclast-mediated bone resorption and modulates bone metabolism, used in the treatment of osteoporosis. | ||
| S2757 | Evofosfamide (TH-302) | Evofosfamide (TH-302)は、19nMのIC50で固形腫瘍の低酸素部位を目標としている選択的な低酸素を起動するプロドラッグです。 | ||
| S4059 | Sodium Nitroprusside Dihydrate | Sodium Nitroprusside Dihydrate is a potent vasodilator working through releasing NO spontaneously in blood. | ||
| S3199 | Reboxetine mesylate | Reboxetine mesylate (PNU 155950E, FCE20124) is a norepinephrine reuptake inhibitor with Ki of 8.2 nM. | ||
| S1806 | Acipimox | Acipimox (Olbemox,K-9321) is a niacin derivative used as a hypolipidemic agent. | ||
| S1875 | Tranexamic Acid | Tranexamic Acid(Transamin) is an antifibrinolytic for blocking lysine-binding sites of plasmin and elastase-derived plasminogen fragments with IC50 of 5 mM. | ||
| E2748 | EGCG Octaacetate | EGCG Octaacetate(AcEGCG) is a pro-drug of epigallocatechin-3-gallate (EGCG). EGCG have potent anti-oxidative, anti-mitotic and anti-angiogenic properties. | ||
| S3992 | D-(+)-Trehalose dihydrate | Trehalose is a non-reducing sugar. It is thought to provide plants and animals with the ability to withstanding periods of dehydration. | ||
| S4567 | Eprodisate disodium | Eprodisate Disodium (NC-503) is the orally available disodium salt form of Eprodisate, a small-molecule, orally bioavailable, inhibitor of AA-amyloid fibrillogenesis. |
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| S6628 | E7820 | E7820 is a unique angiogenesis inhibitor with antitumor activities. | ||
| S4852 | Gadopentetate Dimeglumine | Gadopentetate Dimeglumine (Gadopentetic acid dimeglumine, Gd-DTPA, Meglumine gadopentetate), a complex of gadolinium with a chelating agent, diethylenetriamine penta-acetic acid, is an extracellular intravenous contrast agent used in magnetic resonance imaging. | ||
| S9885 | MYLS22 | MYLS22 is a first-in-class and selective inhibitor of optic atrophy 1 (OPA1) with anti-angiogenesis and anti-cancer activity. | ||
| S3826 | Hydroxytyrosol | Hydroxytyrosol (3,4-dihydroxyphenylethanol) is one of the main phenolic components of olive oil with excellent antioxidant, antimicrobial and anticarcinogenic activities. | ||
| S2060 | Bromhexine HCl | Bromhexine HCl is a medication prescribed for coughs which works by dissolving hard phlegm. | ||
| S5000 | Gadodiamide | Gadodiamide (GDD, Omniscan) is a widely used magnetic resonance imaging (MRI) contrast agent with a high renal toxicity. | ||
| S2374 | 5-hydroxytryptophan (5-HTP) | 5-Hydroxytryptophan (5-HTP, NSC-92523), also known as oxitriptan (INN), is a naturally occurring amino acid and chemical precursor for the treatment of depression. | ||
| S2442 | Inosine | Inosine (NSC 20262, INO 495) is a nucleoside that is formed when hypoxanthine is attached to a ribose ring via a β-N9-glycosidic bond. | ||
| S5763 | D-Mannose | D-mannose is a naturally occurring simple sugar that may help your body cleanse the urinary tract and maintain a healthy bladder lining. | ||
| S4744 | Anethole trithione | Anethole trithione is a drug used in the treatment of dry mouth. | ||
| S5721 | Edetate calcium disodium | Edetate (EDTA) calcium disodium is a chelating agent that is primarily used for the management of severe lead poisoning. | ||
| S6192 | DMF(N,N-Dimethylformamide) | DMF(N,N-Dimethylformamide) is a polar organic solvent with a wide range of industrial applications.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing. | ||
| S5536 | Alendronic Acid | Alendronic acid (alendronate) is a nitrogen-containing, second generation bisphosphonate used for osteoporosis, osteogenesis imperfecta, and several other bone diseases. | ||
| S5906 | 2,4-Pyridinedicarboxylic acid | 2,4-Pyridinedicarboxylic acid (Lutidinic Acid, 2,4-Dicarboxypyridine, 2,4-PDCA) is a compound that structurally mimics 2-oxoglutarate (2-OG) and chelates zinc, thus affecting a range of enzymes. It blocks the activity of 2-OG oxygenases. | ||
| S5504 | Ropivacaine | Ropivacaine is a member of the amino amide class of local anesthetics. | ||
| S6767 | GSK805 | GSK805 (JNJ 56914845, GSK-2336805) is a potent and orally bioavailable RORγt inhibitor. | ||
| S9368 | ADP | ADP (Adenosine diphosphate, adenosine pyrophosphate, Adenosine 5'-diphosphate) is an important organic compound in metabolism and is essential to the flow of energy in living cells. | ||
| S6769 | Curcumin analog C1 | Curcumin analog C1 (Curcumin analog Compound C1) is a potent transcription factor EB (TFEB) activator with promise for the prevention or treatment of Alzheimer's disease. | ||
| S4108 | Clodronate Disodium | Clodronate Disodium, a bisphosphonate, is a potent antiosteolytic agent which inhibits bone resorption. | ||
| S5779 | Trimetazidine | Trimetazidine is an anti-ischemic (anti-anginal) metabolic agent, which improves myocardial glucose utilization through inhibition of long-chain 3-ketoacyl CoA thiolase activity and results in a reduction in fatty acid oxidation and a stimulation of glucose oxidation. | ||
| S9351 | 2'-Deoxyadenosine monohydrate | 2'-Deoxyadenosine may be used as an energy source under energy stress conditions and to affect cAMP levels. | ||
| S4508 | 2,2,2-Tribromoethanol | 2,2,2-Tribromoethanol (TBE, Tribromoethanol) is an organic compound used to anesthetize animals. | ||
| S6475 | Polaprezinc | Polaprezinc (Aprozinate, Carnosine zinc complex, Zinc L-carnosine) is an orally bioavailable chelate composed of zinc and L-carnosine, with potential gastroprotective, anti-oxidant, anti-ulcer and anti-inflammatory activities. | ||
| S4792 | N-Acetylneuraminic acid | N-Acetylneuraminic acid (Neu5Ac, NeuAc, Acido aceneuramico, Acide aceneuramique, Acidium aceneuramicum, Sialic acid, NANA) is the predominant sialic acid found in mammalian cells. Sialic acids are negatively charged monosaccharides attached to the end of sugar chains, giving rise to a wide variety of glycoproteins and glycolipids in biological fluids and cell membranes. | ||
| S5435 | Quinacrine Dihydrochloride Dihydrate | Quinacrine (Mepacrine) is a dye of the acridine family that has been widely used as staining agents for DNA and model compounds for intercalators in numerous biophysical studies. It is also an antimalarial drug. | ||
| S5633 | L-methionine | L-Methionine is an essential sulfur-containing, free-form amino acid, acts as an antioxidant promoter, and contributes to the synthesis of S-adenosyl-L-methionine (SAMe). | ||
| S4821 | Glycine | Glycine (2-Aminoacetic acid, Aminoacetic acid, Glycocoll) is a non-essential, non-polar, non-optical, glucogenic amino acid that is primarily found in gelatin and silk fibroin. It is involved in the body's production of DNA, phospholipids and collagen, and in release of energy. | ||
| S2361 | Stigmasterol | Stigmasterol is an unsaturated plant sterol that exhibits anti-cancer, anti-pyretic, anti-inflammatory and immune-modulating effects. | ||
| S9505 | Oleanonic Acid | Oleanonic Acid (3-Ketooleanolic Acid, 3-Oxooleanolic acid), extracted from Pistacia terebinthus galls, is a cell cycle inhibitor and used as antitumor agents. | ||
| S6002 | Disufenton sodium | Disufenton Sodium (NXY-059, Cerovive) is a novel nitrone, shows efficacious neuroprotective effects. Phase 3. | ||
| S1624 | Alendronate sodium trihydrate | Alendronate sodium trihydrate (G-704650, MK-217), a nitrogen-containing bisphosphonate, is a potent inhibitor of bone resorption used for the treatment and prevention of osteoporosis. | ||
| S1311 | Pamidronate Disodium | Pamidronate Disodium (CGP 23339AE) is a nitrogen containing bisphosphonate, used to prevent osteoporosis.Pamidronate Disodium is a inhibitor of bone resorption factor. | ||
| S2129 | Fudosteine | Fudosteine is a cysteine derivative and a MUC5AC mucin hypersecretion inhibitor, used as a muco-active agent with indications for chronic respiratory diseases. | ||
| S7450 | FH1 | FH1 is a small molecule, which promotes differentiation of iPS-derived hepatocytes. | ||
| S2123 | Dextrose | Dextrose (D-(+)-Glucose), a simple sugar (monosaccharide), is an important carbohydrate in biology. | ||
| S1874 | Risedronate | Risedronate (Risedronic Acid) is a bisphosphonate used to strengthen bone, treat or prevent osteoporosis, and treat Paget's disease of bone. | ||
| S1609 | Methimazole | Methimazole (Tapazole, Thiamazole) is an antithyroid medicine. | ||
| S3148 | Ibandronate sodium monohydrate | Ibandronate (BM-21.0955, BM-210955, RPR-102289A) is a highly potent nitrogen-containing bisphosphonate used for the treatment of osteoporosis. | ||
| S1610 | Metolazone | Metolazone (SR 720-22) is a diuretic that primarily used to treat congestive heart failure and high blood pressure. | ||
| S4020 | Sodium Picosulfate | Sodium Picosulfate inhibits absorption of water and electrolytes, and increases their secretion. | ||
| S2381 | D-Mannitol | D-Mannitol is an osmotic diuretic agent and a weak renal vasodilator. | ||
| S2393 | Sorbitol | Sorbitol (Glucitol) is a sugar alcohol and a sugar substitute. | ||
| S4095 | Difluprednate | Difluprednate (difluoroprednisolone butyrate acetate, DFBA, CM 9155) is a synthetic difluorinated prednisolone derivative, it is originally developed for dermatologic applications. | ||
| E2438 | Ginsenoside Rg3 | Ginsenoside Rg3 is a ginsenoside found in Panax japonicus var. and Panax ginseng, mainly used for the study of tumor diseases. | ||
| S3207 | Iopromide | Iopromide is a low osmolar, non-ionic X-ray contrast agent for intravascular administration. It functions as a contrast agent by opacifying blood vessels in the path of flow of the contrast agent, permitting radiographic visualization of the internal structures until significant hemodilution occurs. | ||
| S5620 | NSI-189 | NSI-189, a small molecule with enhanced neurogenic activity, is a potential antidepressant for the treatment of major depressive disorder (MDD), cognitive impairment and neurodegeneration. | ||
| S0502 | SR8278 | SR8278 is a competitive antagonist of nuclear heme receptor REV-ERB with an EC50 of 0.47 μM for REV-ERBα. | ||
| S3943 | Lycopene | Lycopene (ψ,ψ-Carotene) is a linear, unsaturated hydrocarbon carotenoid, the major red pigment in fruits such as tomatoes, pink grapefruit, apricots, red oranges, watermelon, rosehips, and guava. It is a natural antioxidant. | ||
| S1511 | Lactulose | Lactulose, a disaccharide composed of galactose and fructose, is a stimulator of health-promoting bacterium growth in the gastrointestinal tract, used to treat chronic constipation and hepatic encephalopathy. | ||
| S5300 | Trometamol hydrochloride | Trometamol (THAM, Tromethamine, TRIS-HCL) hydrochloride, a proton acceptor, is a biologically inert amino alcohol of low toxicity, which buffers carbon dioxide and acids in vitro and in vivo. Trometamol rapidly restores pH and acid-base regulation in acidaemia. | ||
| E0157 | 1-Methyl-3-nitro-1-nitrosoguanidine (MNNG) | 1-Methyl-3-nitro-1-nitrosoguanidine (MNNG) is an orally active alkylating agent with toxic and mutagenic effects. It acts as a carcinogen and mutagen among 3 human diploid lymphoblast lines, MIT-2, WI-L2, and GM 130.The product is a solid-liquid mixture.1-Methyl-3-nitro-1-nitrosoguanidine can be used to induce animal models of Gastric Carcinoma. Solutions are unstable and should be fresh-prepared. | ||
| S5621 | Cilastatin | Cilastatin(MK0791) is a renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. | ||
| S6259 | Ureidosuccinic acid | Ureidosuccinic acid (Carbamoyl aspartic acid) is an intermediary product in pyrimidine biosynthesis. | ||
| S1708 | Hydrochlorothiazide | Hydrochlorothiazide is a first line diuretic compound of the thiazide class. | ||
| S5104 | Tea polyphenol | Tea polyphenols are chemical compounds such as flavanoids and tannins found naturally in tea. Several biological properties have been associated to tea polyphenols (TP), including antioxidant, anti-carcinogenic and antimicrobial activities. | ||
| S5176 | Fructose | Fructose (D-(-)-Fructose, Fruit sugar, levulose, fructosteril, D-fructofuranose, D-arabino-hexulose) is a simple ketonic monosaccharide found in many plants. | ||
| S9385 | Ligustilide | Ligustilide is the most abundant bioactive ingredient in Rhizoma Chuanxiong, a Chinese medicinal herb commonly used for the treatment of cardiovascular ailments.Solutions are unstable and should be fresh-prepared. | ||
| E1299 | Polybrene (Hexadimethrine Bromide) | Polybrene (Hexadimethrine bromide) is a cationic polymer which is widely used as supplement for retroviral and lentiviral transduction. | ||
| S5130 | Taurocholic acid sodium salt hydrate | Taurocholic acid (Sodium taurocholate hydrate), a bile salt formed in the liver, is the product of conjugation of cholic acid with taurine that is involved in the emulsification of lipids. Its sodium salt is the chief ingredient of the bile of carnivorous animals.Taurocholic acid sodium salt hydrate can be used to induce animal models of Severe Acute Pancreatitis (SAP). | ||
| S9215 | Pinoresinol diglucoside | Pinoresinol diglucoside, one of the major lignans isolated from Eucommia ulmoides Oliver bark, has various pharmacological functions, including antihypertension and prevention of osteoporosis. | ||
| S9793 | 4-HNE (4-Hydroxynonenal) | 4-HNE (4-Hydroxynonenal) is one of the major end products of lipid peroxidation and has been widely accepted as an inducer of oxidative stress. | ||
| S6987 | Iron Dextran | Iron dextran (Fero Gradumet, Conferon, Fe dextran, INFeD) is an anti-anemia drug that can be used in the study of iron-deficiency anemia in animals. | ||
| S5415 | Enoxaparin sodium | Enoxaparin sodium(PK 10169) is a low-molecular-weight heparin used to prevent and treat deep vein thrombosis or pulmonary embolism. It binds to and accelerates the activity of antithrombin III. | ||
| E2178 | IM-54 | IM-54 is a selective inhibitor of oxidative stress-induced necrosis. IM-54 shows potent inhibitory activity against H2O2-induced necrosis. | ||
| S4115 | Hydroxypropyl Cellulose | Hydroxypropyl cellulose (HPC) is a derivative of cellulose with both water solubility and organic solubility, it is used as food additive and sieving matrix for DNA separations. | ||
| S4128 | Troxipide | Troxipide(KU 54) is a novel systemic non-antisecretory gastric cytoprotective agent with anti-ulcer, anti-inflammatory and mucus secreting properties irrespective of pH of stomach or duodenum. | ||
| S3828 | Orcinol glucoside | Orcinol glucoside (OG, Sakakin) is an active constituent isolated from the rhizomes of Curculigo orchioides Gaertn. It shows potent antioxidative and anxiolytic activities without sedative effects. | ||
| S5221 | Diludine | Diludine (Ethidine, Diethone) is a synthetic antioxidant agent. | ||
| E0492 | 20R-Camptothecin | 20R-Camptothecin, one of Camptothecin Derivatives, has little or no effect on topoisomerase I, in contrast to the natural S isomer. |
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| S2252 | (+)-Usniacin | (+)-Usniacin (D-Usnic Acid) is a naturally occurring dibenzofuran derivative found in several lichen species. | ||
| S2253 | 3-Indolebutyric acid (IBA) | 3-Indolebutyric acid(IBA) is a plant hormone in the auxin family and is an ingredient in many commercial plant rooting horticultural products. | ||
| S6831 | HEPES | HEPES is a nonvolatile zwitterionic chemical buffering agent, which is broadly applied in cell culture. HEPES is effective at pH 6.8 to 8.2. HEPES is also a potent inducer of lysosome biogenesis. | ||
| S6828 | Cremophor EL | Cremophor EL, a polyethoxylated surfactant, is a formulation vehicle used for various poorly-water soluble drugs, including the anticancer agent paclitaxel (Taxol). Cremophor EL is used in severe anaphylactoid hypersensitivity reactions, hyperlipidaemia, abnormal lipoprotein patterns, aggregation of erythrocytes and peripheral neuropathy. | ||
| E0498 | BMS-986176 | BMS-986176 (LX-9211,AAK1-IN-1) is a highly selective, brain-penetrant, potent AAK1 (adaptor associated kinase 1) inhibitor with an IC50 of 2 nM. | ||
| S6829 | DTT (Dithiothreitol) | DTT (Dithiothreitol), a small-molecule redox reagent, is a standard agent for reducing disulfide bonds between and within biological molecules.Solutions are best fresh-prepared. | ||
| S2258 | Esculin | Esculin (Aesculin) is a glucoside found in horse chestnuts. | ||
| S4040 | Norethindrone | Norethindrone (Norethisterone) is a synthetic progestin, which mimic the actions of the endogenous ovarian hormone progesterone. | ||
| S5755 | Methyl Eugenol | Methyl eugenol (4-allylveratrole, eugenyl methyl ether, O-methyleugenol), as a constituent in leaves, fruits, stems, and/or roots, is used as a flavoring agent, as a fragrance and as an anesthetic in rodents. | ||
| S3131 | L-(-)-Glucose | L-Glucose (L-(-)-Glucose) is an enantiomer of D-glucose. L-Glucose promotes food intake while cannot be used by cells as an energy source because it cannot be phosphorylated by hexokinase. |
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| S6364 | 1-Hydroxy-2-naphthoic acid | 1-Hydroxy-2-naphthoic acid is a xenobiotic metabolite produced by the biodegradation of phenanthrene by microorganisms. | ||
| S2267 | Azomycin | Azomycin (2-Nitroimidazole) is an antimicrobial antibiotic produced by a strain of Nocardia mesenterica. | ||
| S6367 | 3-Hydroxybenzoic acid | 3-Hydroxybenzoic acid (m-Hydroxybenzoic acid, 3-Carboxyphenol, m-Salicylic acid) is used as an intermediate in the synthesis of plasticisers, resins, pharmaceuticals, etc. | ||
| E1213 | Emlenoflast (MCC-7840) | Emlenoflast (MCC-7840), a sulfonylurea, is a potent and selective inhibitor of NLRP3 inflammasome, with an IC50 of <100 nM. | ||
| S5526 | β-Alanine | β-Alanine (beta-Alanine, 3-Aminopropanoic acid) is a naturally occurring beta amino acid formed in vivo by the degradation of dihydrouracil and carnosine. It acts as a neurotransmitter by activating glycine and GABA receptors. | ||
| S2273 | β-Sitosterol | β-Sitosterol (SKF 14463, 22,23-Dihydrostigmasterol) is one of several phytosterols (plant sterols) with chemical structures similar to that of cholesterol. | ||
| A2119 | Rat IgG1 isotype control-InVivo | Rat IgG1 isotype control-InVivo monoclonal antibody (Clone:HRPN) reacts with horseradish peroxidase (HRP). Because HRP is not expressed by mammals this antibody is ideal for use as an isotype-matched control for rat IgG1 antibodies in most in vivo and in vitro applications. |
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| S4829 | Magnesium lactate trihydrate | Magnesium lactate, the magnesium salt of lactic acid, is a mineral supplement that is added to some food and beverages as an acidity regulator. | ||
| S6129 | Aminomalonic acid | Aminomalonic acid (Aminomalonate, Aminopropanedioic acid) is an amino dicarboxylic acid. It has a role as a human metabolite and a Daphnia magna metabolite. | ||
| S6790 | Ellipticine hydrochloride | Ellipticine Hydrochloride (NSC 71795, PZE) is a potent inhibitor of DNA topoisomerase II and forms covalent DNA adducts mediated by its oxidation with cytochromes P450 (CYP) and peroxidases. Ellipticine Hydrochloride is a natural product isolated from the Australian evergreen tree of the Apocynaceae family with antineoplastic activity. | ||
| S4965 | Helecin | Helecin (Helicin) is the O-glucoside of salicylaldehyde, which is a key precursor to a variety chelating agents. | ||
| E0111 | BRM/BRG1 ATP Inhibitor-1 | BRM/BRG1 ATP Inhibitor-1 (Compound 14) is an orally active inhibitors of Brahma Homolog (BRM)/SMARCA2 (BRG1) with IC50s below 0.005 µM. | ||
| S9009 | 23-Hydroxybetulinic acid | 23-Hydroxybetulinic acid is a natural lupanetype pentacyclic triterpene isolated from the root of traditional Chinese herb Pulsatilla chinensis with remarkable antineoplastic activities. | ||
| S0798 | PZ-2891 | PZ-2891 is a selective, orally active and brain-penetrant pantothenate kinase (PANK) modulator that acts as an orthosteric inhibitor at high concentrations and an allosteric activator at lower sub-saturating concentrations. PZ-2891 inhibits PANK with IC50 of 40.2 nM, 0.7 nM and 1.3 nM for hPANK1β, hPANK2, and hPANK3, respectively. | ||
| S1974 | Meglumine | Meglumine(Meglumin,Methylglucamine) is an amino sugar derived from sorbitol for THP-1 cells with IC50 of 22 μg/mL. | ||
| S6250 | L-Lactic acid | L-Lactic acid is a natural product that is used as a food additive. | ||
| S9305 | Toosendanin | Toosendanin, a triterpenoid extracted from Melia toosendan Sieb et Zucc, possesses broad biological actions from blocking neurotransmission and antibotulism to inducing cell differentiation and apoptosis. | ||
| S6258 | 1,2-Propanediol | 1,2-Propanediol (1,2-Dihydroxypropane, Propylene glycol, Methyl ethyl glycol) is a synthetic liquid substance that is commonly used as an excipient in a variety of drugs and it is also authorised in food products and cosmetics. | ||
| S8870 | Epibrassinolide | Epibrassinolide is a brassinosteroid isolated from various plants and has been shown to decrease toxicity and stimulate healthy plant growth in plants under stress. | ||
| S9312 | Cyanidin-3-O-glucoside chloride | Cyanidin-3-O-glucoside chloride (Kuromanin, Chrysontemin, Glucocyanidin) is a natural product with anti-oxidant and neuroprotective effects. | ||
| S9020 | Dihydrotanshinone I | Dihydrotanshinone I (15,16-dihydrotanshinone I) is a naturally occurring compound extracted from Salvia miltiorrhiza Bunge, also known as Chinese sage, red sage root, and the Chinese herbal Dan Shen. It is a potent inhibitor of the HuR:RNA interaction, active in the low nanomolar range, mainly by limiting the association rate of HuR with RNA. | ||
| S6590 | Hydrocortisone butyrate | Hydrocortisone butyrate is a potent topical corticosteroid that can be used to treat a range of inflammatory skin conditions. | ||
| S3915 | Gracillin | Gracillin, a kind of steroidal saponin isolated from the root bark of wild yam Dioscorea nipponica, has been reported to exert antitumor activity. | ||
| E2902 | Sodium Pyruvate | Sodium Pyruvate(Sodium 2-oxopropanoate) is a compound produced in the glycolytic pathway. Sodium Pyruvate is a free radical scavenger that can scavenge ROS. | ||
| S3095 | Itaconic acid | Itaconic acid, a macrophage-specific (Mϕ-specific) metabolite, mediates crosstalk between macrophage metabolism and peritoneal tumors. Itaconic acid is also a precursor of polymers, chemicals, and fuels that can be synthesized by many fungi. |
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| S3677 | Cinnamic acid | Cinnamic acid (Benzenepropenoic acid, Isocinnamic acid, trans-Cinnamic acid, Phenylacrylic acid), a naturally occurring aromatic fatty acid of low toxicity, induces cytostasis and a reversal of malignant properties of human tumor cells in vitro. | ||
| S4070 | Guanidine HCl | Guanidine HCl (Aminoformamidine), the crystalline compound of strong alkalinity formed by the oxidation of guanine, is a normal product of protein metabolism and a protein denaturant. | ||
| S6421 | Diroximel Fumarate | Diroximel Fumarate, also known as ALKS-8700, is a prodrug of monomethyl fumarate in a controlled-release formulation that rapidly and efficiently converts to MMF in the body. | ||
| S6585 | Triethylenetetramine 2HCl | Triethylenetetramine 2HCl, a Cu(II)-selective chelator, is commonly used for the treatment of Wilson's disease. | ||
| S4664 | Molsidomine | Molsidomine (SIN-10, Corvaton, Morsydomine) is an orally active, long acting vasodilating drug. Molsidomine is metabolized in the liver to the active metabolite linsidomine. Linsidomine is an unstable compound that releases nitric oxide (NO) upon decay as the actual vasodilating compound. | ||
| S5513 | Calcium D-saccharate tetrahydrate | Calcium D-saccharate tetrahydrate (Calcium Saccharate, D-Saccharic acid calcium salt, D-Glucaric acid calcium salt) is the calcium salt form of glucaric acid, a natural substance found in many fruits and vegetables, with potential anti-cancer property. | ||
| S6023 | Creatine monohydrate | Creatine (Methylguanidoacetic acid) is a key player in the phosphagen energy system, the primary source of ATP during short-term, high intensity activities. | ||
| S4691 | Oxybenzone | Oxybenzone (Eusolex 4360, Escalol 567, KAHSCREEN BZ-3, Benzophenone 3) is a benzophenone derivative used as a sunscreen agent. | ||
| S5518 | D-Glucose 6-phosphate disodium salt | D-Glucose 6-phosphate disodium salt is the disodium salt form of D-Glucose 6-phosphate, a common form of glucose within the cell, participating in two major metabolic pathways: glycolysis and the pentose phosphate pathway. It can be coverted to glycogen or starch for storage. | ||
| S6083 | DL-Dopa | DL-Dopa (3,4-Dihydroxy-DL-phenylalanine) is an immediate precursor of dopamine. | ||
| S1924 | Indocyanine green | Indocyanine green(Cardiogreen) is a cyanine dye that binds to plasma proteins and lipoproteins. It is used in medical diagnostics. It is used for determining cardiac output, hepatic function, and liver blood flow, and for ophthalmic angiography. Indocyanine green-photodynamic therapy(ICG-PDT) induces apoptosis in HGF cells at transcriptome level. | ||
| S7451 | FPH1 | FPH1 is a small molecule, which promotes expansion of iPS-derived hepatocytes. | ||
| S5794 | Glycochenodeoxycholic acid | Glycochenodeoxycholic acid (Glycochenodeoxycholate, Chenodeoxycholylglycine, Glycine chenodeoxycholate) is a bile salt formed in the liver from chenodeoxycholate and glycine. It acts as a detergent to solubilize fats for absorption. Glycochenodeoxycholic acid | ||
| S9366 | 5'-Adenylic acid | AMP, also known as 5'-Adenylic acid and Adenosine monophosphate, is a nucleotide that is found in RNA. It is used as a dietary supplement to boost immune activity, and is also used as a substitute sweetener to aid in the maintenance of a low-calorie diet. | ||
| S6011 | Acetamide | Acetamide (ethanamide, Acetic acid amide) is an organic compound that can be used as a plasticizer and an industrial solvent. | ||
| S0145 | ML329 | ML329 is an inhibitor of micropthalmia-associated transcription factor (MITF) that inhibits TRPM-1 promoter activity with IC50 of 1.2 μM. | ||
| S3937 | Pterostilbene | Pterostilbene is a natural dietary compound and the primary antioxidant component of blueberries. It has been implicated in anticarcinogenesis, modulation of neurological disease, anti-inflammation, attenuation of vascular disease, and amelioration of diabetes. | ||
| S2316 | Kinetin | Kinetin (6-Furfuryladenine) is a type of cytokinin, a class of plant hormone that promotes cell division. | ||
| S3934 | Acetyl Resveratrol | Acetyl Resveratrol is the derivative compound of resveratrol, which is a potent phenolic antioxidant found in grapes and red wine. | ||
| S5182 | GSK4112 | GSK4112 is a functional Rev-erbα agonist with an EC50 of 0.4 μM. It represses the expression of gluconeogenic genes in liver cells and reduces glucose output in primary hepatocytes. | ||
| S1024 | LTI-291 | LTI-291 is the first small-molecule activator of Glucocerebrosidase(GCase) for the treatment of parkinson's disease. | ||
| S4092 | Pramoxine HCl | Pramoxine(Pramocaine hydrochloride) is a topical local anesthetic that has been shown to have antipruritic properties. |
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| S9077 | Plantamajoside | Plantamajoside (Y0160, C10485), a hydroxycinnamic acid, is used as a biomarker in chemotaxonomical studies, and is a compound with numerous biological applications and considerable pharmacological potential. | ||
| S9080 | Anhydroicaritin | Anhydroicaritin (Cycloicaritin), a prenylated flavonoid natural product, is commonly recognized as one of the effective compounds of Epimedii Herba and exhibits a variety of biological activities, such as activation of cancer cell apoptosis and inhibition of growth, protection against beta amyloid-induced neurotoxicity, and promotion of neuronal and cardiac cellular differentiation. It is a potent inhibitor of transcription factor SREBPs. | ||
| E1010 | BZ1 | BZ1 (BPTF inhibitor, BPTF-IN-BZ1) is a pyridazinone-based BPTF (Bromodomain PHD Finger Transcription Factor) inhibitor with a high potency (Kd = 6.3 nM) and >350-fold selectivity over BET bromodomains. | ||
| S3795 | Phloretic acid | Phloretic acid (Desaminotyrosine, Hydro-p-coumaric acid, Phloretate, 3-(4-Hydroxyphenyl)propanoic acid) is a naturally occurring phenolic compound which can be produced by the hydrogenation of p-coumaric acid or synthesized from phloretin, a by-product of apple tree leaves. | ||
| S9081 | Anemoside B4 | Anemoside B4 (Pulchinenoside B4, Chinensioside A, Pulchinenoside C, Pulsatilla saponin B4), extracted from the herb of Pulsatilla chinensis (Bge.) Regel, is a potential antiviral constituent and inhibits the secretion of IL-10. | ||
| S1904 | Avobenzone | Avobenzone (Butyl methoxydibenzoylmethane, BF2AVB) is an oil soluble ingredient used in sunscreen products to absorb the full spectrum of UVA rays and a dibenzoylmethane derivative. | ||
| S4598 | EGTA | EGTA is a specific calcium ion chelator. This product has poor solubility, animal experiments are available, cell experiments please choose carefully! | ||
| S4214 | Sucralose | Sucralose (E955m,Trichloro Sucrose) is an artificial and noncaloric sweetener, not broken down by the body. | ||
| S4801 | 6-Chloropurine | 6-Chloropurine is used in the preparation of 9-alkylpurines through alkylation with various substituted alkyl halides in dimethyl sulfoxide. | ||
| S3694 | Glucosamine hydrochloride | Glucosamine (2-Amino-2-deoxy-glucose, Chitosamine) is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, also presents in the shells of shellfish, animal bones, bone marrow, and fungi. Glucosamine is commonly used as a treatment for osteoarthritis, although its acceptance as a medical therapy varies. | ||
| S9420 | Sinoacutine | Sinoacutine (Salutaridine), isolated from the Chinese drug Ching-fengteng, elicits mild antitussive properties. | ||
| S4762 | 2,4-Dihydroxyacetophenone | 2,4-Dihydroxyacetophenone (Resacetophenone, 4-Acetylresorcinol) is a plant metabolite that can act as a qualitative reagent for ferric iron. | ||
| S5733 | Stearic acid | Stearic acid (Octadecanoic acid, Isostearic acid, Cetylacetic acid) is a natural saturated fatty acid found in animal and vegetable fats. It could be used as a food additive and used in soaps, cosmetics and detergents. | ||
| S3805 | Stevioside | Stevioside is a natural sweetener extracted from leaves of Stevia rebaudiana (Bertoni) Bertoni. | ||
| S9110 | Morin | Morin (Al-Morin, Aurantica, Calico Yellow, Toxylon pomiferum), a constituent of various woods, has a role as an antioxidant, a metabolite, an antihypertensive agent, a hepatoprotective agent, a neuroprotective agent, an anti-inflammatory agent, an antineoplastic agent, an antibacterial agent, a DNA topoisomerase inhibitor and an angiogenesis modulating agent. | ||
| S0189 | PMPA tetrasodium salt | PMPA tetrasodium salt (PMPA sodium) is a potent and selective inhibitor of glutamate carboxypeptidase 2 (GCP II/NAALADase). | ||
| S4770 | Creatine phosphate disodium salt | Phosphocreatine, also known as creatine phosphate (CP) or PCr (Pcr), is a phosphorylated creatine molecule that serves as a rapidly mobilizable reserve of high-energy phosphates in skeletal muscle and the brain to recycle adenosine triphosphate, the energy currency of the cell. | ||
| S6111 | L-Hydroorotic acid | L-Dihydroorotic acid (L-dihydroorotate) is an intermediate in the metabolism of Pyrimidine. It is a substrate for Dihydroorotate dehydrogenase (mitochondrial). | ||
| S3742 | Cholic acid | Cholic acid is a naturally occurring bile acid that is insoluble in water and is used to treat patients with genetic deficiencies in the synthesis of bile acids. | ||
| S9121 | Irigenin | Irigenin, an O-methylated isoflavone, can be isolated from the rhizomes of the leopard lily (Belamcanda chinensis), and Iris kemaonensis. | ||
| S5381 | Behenic Acid | Behenic Acid (docosanoic acid) is a long-chain saturated fatty acid that exists naturally as a triglyceride in canola. It act as a lubricant that helps restore the skin's natural oils and improve overall levels of hydration. | ||
| S3730 | Metaxalone | Metaxalone (Skelaxin, Methaxalonum, Zorane) is a muscle relaxant used to relax muscles and relieve pain caused by strains, sprains, and other musculoskeletal conditions. | ||
| S0206 | CTX-0294885 | CTX-0294885, a bisanilino pyrimidine, is a novel broad-spectrum kinase inhibitor. CTX-0294885 is further developed into a Sepharose-supported kinase capture reagent. | ||
| E0183 | Magnesium chloride | Magnesium chloride can reduce the activated thromboplastin times. | ||
| S2965 | (R)-(-)-JQ1 Enantiomer | (R)-(-)-JQ1 Enantiomer is the stereoisomer of (+)-JQ1. (+)-JQ1 potently decreases expression of both BRD4 target genes, whereas (R)-(-)-JQ1 Enantiomer has no effect. | ||
| S5236 | β-Estradiol 17-Acetate | β-Estradiol 17-Acetate is a metabolite of estradiol which is an estrogen steroid hormone and the major female sex hormone. | ||
| S9007 | 2'-Deoxyguanosine monohydrate | 2'-Deoxyguanosine monohydrate is a kind of purine nucleoside. | ||
| S6155 | L-Tryptophanamide Hydrochloride | L-tryptophanamide (H-Trp-NH2) is an amino acid amide that is the carboxamide of L-tryptophan. | ||
| E0046 | β-Cyclodextrin | β-Cyclodextrin (β-CD, Beta-Cyclodextrin) is a cyclic derivative of starch prepared from partially hydrolyzed starch (maltodextrin) by an enzymatic process. β-Cyclodextrin can be used as complexing agents to increase aqueous solubility of poorly soluble drugs and to increase their bioavailability and stability. | ||
| S4809 | 3-Indolepropionic acid | 3-Indolepropionic acid (IPA, indole-3-propionic acid), a gut microbial metabolite, is a potent neuroprotective antioxidant and plant auxin. | ||
| S5124 | DL-Citrulline | L-Citrulline (Citrulline, Cit) is a naturally occurring nonessential amino acid which is the key intermediate in the urea cycle. | ||
| S5634 | L-arginine | Arginine is an important amino acid used in the biosynthesis of proteins. L-arginine plays an important role in immune regulation by affecting the immune response and inflammation. It is also implicated in cell division, wound healing and the release of hormones.L-arginine can be used to induce animal models of Acute pancreatitis. | ||
| S2354 | Sclareol | Sclareol, a labdane-type diterpene isolated from clary sage (Salvia sclarea), exerts growth inhibition and cytotoxic activity against a variety of human cancer cell lines. |
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| S1900 | Talc | Talc is a mineral composed of hydrated magnesium silicate with the chemical formula H2Mg3(SiO3)4 or Mg3Si4O10(OH)2. | ||
| S3869 | Methyl protocatechuate | Methyl protocatechuate (Methyl 3,4-dihydroxybenzoate, 3,4-Dihydroxybenzoic acid methyl ester, Protocatechuic Acid Methyl Ester) is also known as Protocatechuic Acid Methyl Ester. Protocatechuic Acid, a dihydroxybenzoic acid, is a major metabolite of antioxidant polyphenols found in green tea with antioxidant and anti-inflammatory effects. | ||
| S4493 | Sodium nitroprusside | Sodium nitroprusside (SNP, Ro 21-2498) is a generically available and rapid-acting intravenous (IV) vasodilator that dilates cerebral vessels and increases internal carotid (ICA) flow. | ||
| E0136 | N-Nitrosodiethylamine | N-Nitrosodiethylamine (N-Nitroso-diethylamine, NDEA, diethylnitrosamine, DEN) is DNA reactive after bioactivation and produces tumors in many animal species.N-Nitrosodiethylamine can be used to induce animal models of Lung Carcinoma. | ||
| S3237 | Deoxyaconitine | 3-Deoxyaconitine is a diterpenoid alkaloid isolated from the root of Aconitum Carmichaeli Debx. | ||
| S6205 | N-Acetyl-L-methionine | N-Acetyl-L-methionine (Ac-Met-OH) is an L-methionine derivative that is nutritionally and metabolically equivalent to L-methionine. It is a superior ROS scavenger. | ||
| S6210 | Ethanolamine hydrochloride | Ethanolamine (2-Aminoethanol) is a viscous, hygroscopic amino alcohol with an ammoniacal odor. It is widely distributed in biological tissue and is a component of lecithin. | ||
| S9178 | Sinapine thiocyanate | Sinapine thiocyanate is the thiocyanate salt form of Sinapine, which shows favorable biological activities such as antioxidant and radio-protective activities. | ||
| S5433 | Sodium succinate | Sodium succinate (Sodium 3-carboxypropanoate, Disodium butanedioate) is the sodium salt form of succinate, which is an important metabolite at the cross-road of several metabolic pathways and involved in the formation and elimination of reactive oxygen species. | ||
| S9513 | Senkyunolide A | Senkyunolide A is one of the major bioactive ingredients in Rhizoma Chuanxiong, a Chinese medicinal herb commonly used for the treatment of cardiovascular ailments. | ||
| S3987 | L-Tryptophan | L-tryprophan is an essential amino acid that acts like a natural mood regulator that is necessary for normal growth in infants and for nitrogen balance in adults. | ||
| S3927 | Swertiamarin | Swertiamarin (Swertiamaroside) is a common secoiridoid found among the members of Gentianaceae with anti-inflammatory, anticancer, hypoglycemic and hypolipidemic activities. | ||
| S9338 | Octyl gallate | Octyl gallate (Progallin O, n-Ocyl gallate, Stabilizer GA-8, Gallic acid octyl ester), a widely used food additive, shows antimicrobial and antioxidant activity. | ||
| S6781 | Brassinazole | Brassinazole (BRZ) is a potent inhibitor of brassinosteroid (BR) biosynthesis with IC50 of ~ 1 μM, that has been developed to probe the myriad functions of brassinosteroids. Brassinosteroids are a class of phytohormones with essential roles in plant growth and development, including the promotion of stem elongation and cell division. | ||
| S1201 | Dimesna | Dimesna (BNP-7787) is an uroprotective agent used to decrease urotoxicity. | ||
| S1897 | Potassium Iodide | Potassium Iodide is used to treat overactive thyroid and to protect the thyroid gland from the effects of radiation from inhaled or swallowed radioactive iodine. | ||
| S1740 | Guaifenesin | Guaifenesin is an expectorant used to relieve chest congestion. | ||
| S2594 | Pramiracetam | Pramiracetam (CI-879,Pramistar) is a more potent nootropic drug derived from piracetam. | ||
| S1671 | (6-)ε-Aminocaproic acid | (6-)ε-Aminocaproic acid is a derivative and analogue of the amino acid lysine. | ||
| S1853 | Penicillamine | Penicillamine (Dimethyl Cysteine) is used as an antirheumatic and as a chelating agent in Wilson’s disease. | ||
| S3004 | Telithromycin | Telithromycin is a ketolide antibiotic to treat community acquired pneumonia of mild to moderate severity. | ||
| S1641 | Chlorothiazide | Chlorothiazide is a diuretic and antihypertensive. (IC50=3.8 mM) | ||
| S2293 | DL-Carnitine HCl | DL-Carnitine HCl is a quaternary ammonium compound biosynthesized from the amino acids lysine and methionine. | ||
| S2305 | Grape Seed Extract | Grape Seed Extract are industrial derivatives from whole grape seeds that have a great concentration of vitamin E, flavonoids, linoleic acid, and OPCs. | ||
| S1667 | Trichlormethiazide | Trichlormethiazide is a diuretic with properties similar to those of hydrochlorothiazide. | ||
| S1928 | Alibendol | Alibendol (EB 1856) is an antispasmodic,choleretic, and cholekinetic. | ||
| S3991 | Ketoisophorone | Ketoisophorone (4-Oxoisophorone), also known as 4-Oxoisophorone, is the major component of saffron spice. | ||
| S5228 | Minoxidil sulphate | Minoxidil is a potent direct-acting peripheral vasodilator that reduces peripheral resistance and produces a fall in blood pressure. | ||
| S9383 | Methyl palmitate | Methyl palmitate (Methyl hexadecanoate, Palmitic acid methyl ester), a kind of fatty acid methyl ester, could be found in many plants and possesses acaricidal activity. | ||
| S9188 | Magnoflorine chloride | Magnoflorine (Escholine, Thalictrine, Corytuberine methochloride), isolated from the rhizome of Sinomenium acutum and from Pachygone ovata, is usually used as an anxiolytic chemical with anti-oxidant, α-tyrosinase inhibitory and anti-inflammationary activities. | ||
| S9517 | Liriope muscari baily saponins C | Liriope muscari baily saponins C, extracted from the roots of Liriope muscari (Decne.) Baily, induces autophagy and has an anti-thrombotic activity. | ||
| S6233 | L-Tartaric acid | L-Tartaric acid (2,3-Dihydroxysuccinic acid, Threaric acid, Racemic acid, Uvic acid, Paratartaric acid, Winestone) is a white crystalline organic acid that occurs naturally in many plants, most notably in grapes. It has several applications for industrial and pharmaceutical use. | ||
| S6529 | NIH-12848 | NIH-12848 is a specific PI5P4Kγ inhibitor with an IC50 of approximately 1 μM but does not inhibit the α and β PI5P4K isoforms at concentrations up to 100 μM. | ||
| S6973 | TJ191 | TJ191 is a selective anti-cancer small molecule that targets low TβRIII-expressing malignant T-cell leukemia/lymphoma cells. | ||
| A2031 | Sacituzumab (anti-Trop-2) | Sacituzumab (anti-Trop-2) is a fully humanized IgG1 kappa monoclonal antibody that binds Trop-2. | ||
| S4566 | DL-Panthenol | DL-panthenol (DL-Pantothenol, DL-Pantothenyl alcohol) is a racemic mixture of D and L form of panthenol,a provitamin of B5. | ||
| S4802 | 6-Methylcoumarin | 6-Methylcoumarin (Toncarine), a synthetic fragrance widely used in cosmetics, belongs to the class of organic compounds known as coumarins and derivatives. | ||
| S6234 | Pentadecanoic acid | Pentadecanoic acid is a saturated fatty acid of exogenous (primarily ruminant) origin. It also has a role as a plant metabolite, a food component, a Daphnia magna metabolite, a human blood serum metabolite and an algal metabolite. | ||
| S3314 | 2-Methylpentanoic acid | 2-Methylpentanoic acid (2-Methylvaleric acid, Methylpropylacetic acid) is a short-chain fatty acid that exists in various foods including cheeses, cherimoya, lamb and mutton, and so on. 2-Methylpentanoic acid is a flavor compound used for food-flavor ingredient, fragrances. |
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| E4020 | 1-Oleoyl-rac-glycerol | 1-Oleoyl-rac-glycerol (Monoolein) is an endogenous metabolite, also an example of lipid-based nanomaterial. It is commonly utilized to prepare lyotropic cubic liquid crystalline drug delivery systems due to its physicochemical properties. | ||
| S5224 | Adrafinil | Adrafinil (benzhydrylsulfinylacetohydroxamic acid, adrafinyl, CRL-40028) is a mild central nervous system stimulant drug directly affecting CNS function. It is used to relieve excessive sleepiness and inattention in elderly patients. | ||
| S9363 | Coumarin 151 | Coumarin 151 (7-Amino-4-(trifluoromethyl)coumarin) is a fluorescent tracer used for the detection of proteinases. | ||
| S6975 | N-Vanillyldecanamide | N-Vanillyldecanamide is a capsaicinoid isolated from the fruits of Capsicum annuum, which can significantly reduce the radical length of Lactuca sativa seedling in a dose-dependent manner. | ||
| E0528 | Flecainide | Flecainide is a common medication used to help restore and maintain sinus rhythm in patients with atrial fibrillation. | ||
| E2958 | Toluidine Blue O | Toluidine Blue O (Toluidine Blue) is a thiazine dye of the quinone-imine family and is cationic in nature. Toluidine Blue O along with light-emitting diode has been used as a photosensitizer to control in vitro biofilms and to kill gram-negative bacteria. Toluidine Blue has wide applications in vital staining in living tissues and used as a special stain. | ||
| S4568 | Ethylvanillin | Ethylvanillin (Ethylprotal, Bourbonal, Rhodiarome) is the organic flavorant. It is about three times as potent as vanillin and used in the production of chocolate. | ||
| S3994 | Methyl Cholate | Methyl Cholate (Cholic acid methyl ester) is methyl ester form of Cholic acid that is a primary bile acid mainly produced by the liver. | ||
| S9453 | 2-Undecanol | 2-Undecanol (Methyl nonyl carbinol, 2-Hydroxyundecane, 2-Hendecanol) is a fatty alcohol lipid molecule. | ||
| S9191 | Loganic acid | Loganic acid (Loganate) is a naturally occurring iridoid monoterpeneglusoside involved in the biosynthesis of indole alkaloids in Vinca rosea. | ||
| S6119 | 2-Hydroxybutyric acid | 2-Hydroxybutyric acid (α-hydroxybutyrate) is converted from 2-Aminobutyric acid. It is produced in mammalian tissues (principally hepatic) that catabolize L-threonine or synthesize glutathione. | ||
| S6751 | Brevianamide F | Brevianamide F, belonging to a class of naturally occurring 2,5-diketopiperazines, is the simplest member and the biosynthetic precursor of a large family of biologically active prenylated tryptophan-proline 2,5-diketopiperazines that are produced by the fungi A.fumigates and Aspergillus sp.. | ||
| S3266 | L-Anserine nitrate salt | L-Anserine nitrate salt, a dipeptide found in most animal tissues, exhibits antioxidant properties, anti-crosslinking, and anti-glycation activities. L-Anserine protects against neurotoxicity induced by ER-stress inducers. |
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| S3461 | RH01687 | RH01687 is a potent β-cell protector that exhibits β-cell-protective activities against endoplasmic reticulum (ER) stress. | ||
| S4730 | Pyrithioxin Dihydrochloride | Pyrithioxin (Bonifen, Encefabol, Pyritinol, Vitamin B6 disulfide) Dihydrochloride is a neurotropic agent which reduces permeability of blood-brain barrier to phosphate with no vitamin B6 activity. | ||
| E0530 | Prednicarbate | Prednicarbate (Dermatop) is a medium potency topical corticosteroid used to manage pruritus and inflammation associated with responsive skin conditions. | ||
| E4030 | N-p-Tosyl-L-phenylalanine chloromethyl ketone | N-p-Tosyl-L-phenylalanine chloromethyl ketone (Tosyl phenylalanyl chloromethyl ketone, TPCK) is an irreversible inhibitor of chymotrypsin-like proteases that affect cell proliferation, apoptosis, and tumorigenesis. | ||
| S3995 | Guaiazulene | Guaiazulene (Azulon, Vetivazulen) is a bicyclic sesquiterpene that is a constituent of some essential oils, mainly oil of guaiac and chamomile oil, which also serve as its commercial sources. | ||
| S6241 | β-D-Glucose pentaacetate | β-D-Glucose pentaacetate is an enantiomer of D-glucose pentaacetate. | ||
| S3265 | 9''-Methyl salvianolate B | 9''-Methyl salvianolate B (9'-methyllithospermate B, 9'-Methyl lithospermate B, 9'''-Methyl salvianolate B) is an active constituent in ethanol extract of Radix Salviae Miltiorrhizae. | ||
| S4570 | Halothane | Halothane (Narcotane) is a general inhalation anesthetic used for induction and maintenance of general anesthesia. | ||
| S3983 | Caryophyllene oxide | "Caryophyllene oxide, an oxygenated terpenoid existed in many plant essential oil, is well known as preservative in food, drugs and cosmetics with anti-inflammatory, anti-carcinogenic and skin enhan- cing properties. " | ||
| S3996 | Thioctic acid | Thioctic acid (DL-α-Lipoic acid) is a cyclic disulfide antioxidant that interconverts with its reduced dithiol form. | ||
| S9333 | Gibberellins A4/A7 | Gibberellins A4/A7 (Gibberellin A4 and A7) is the Gibberellin A4 Mixture With Gibberellin A7. Gibberellins A4/A7 promotes internode elongation & breaks certain dormancies in seeds. Gibberellins A4/A7 is an endogenous plant growth regulator, promotes the growth and elongation of cells. | ||
| S0712 | Endoxifen E-isomer | Endoxifen E-isomer (E-Endoxifen), an E-isomer of Endoxifen and impurity in Endoxifen Z-isomer drug substance, exhibits antiestrogenic effects. | ||
| S2989 | Nα-Acetyl-L-asparagine | Nα-Acetyl-L-asparagine (N-Acetylasparagine, (S)-2-acetamido-4-amino-4-oxobutanoic acid) is an endogenous metabolite that exists in human brain. |
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| S4857 | L-Ornithine | L-ornithine ((S)-2,5-Diaminopentanoic acid) has an antifatigue effect by increasing the efficiency of energy consumption and promoting the excretion of ammonia. It is one of the key reactants in the urea cycle. | ||
| E0155 | 4-Nitroquinoline 1-oxide | 4-Nitroquinoline 1-oxide (4-Nitroquinoline-N-oxide, 4-NQO, 4NQO, 4Nqo, NQO, NQNO) is a highly carcinogenic model chemical that induces mutations in bacteria, fungi, and animals through the formation of bulky purine adducts.4-Nitroquinoline 1-oxide can be used to induce animal models of Squamous Cell Carcinoma. | ||
| E0178 | Cysteamine bitartrate | Cysteamine bitartrate (Mercaptamine bitartrate) is an FDA-approved cystine-depleting aminothiol agent for the treatment of nephropathic cystinosis to decrease accumulation of lysosomal cystine by engaging in disulfide exchange. In addition, cysteamine bitartrate has antioxidant properties. | ||
| E1484 | PDS-0330 | PDS-0330 is an inhibitor of Claudin-1, which inhibits claudin1-mediated signalling by interfering with its binding to Src. PDS-0330 exhibits an antitumor effect and enhances apoptosis in colorectal cancer cells. | ||
| E4033 | 4-Nitrophenyl beta-D-glucopyranoside | 4-Nitrophenyl beta-D-glucopyranoside is a chromogenic β-D-glucosidase substrate, producing a yellow solution upon cleavage. It is degraded by hydrolysis of enzyme β-glucosidase and quantified by colorimetric detection at 405 nm as a measure of β-glucosidase activity. | ||
| E1360New | BAY-069 | BAY-069 is a potent dual inhibitor of BCAT1/2 (branched-chain amino acid transaminases), with IC50 values of 31 nM for BCAT1 and 153 nM for BCAT2. It demonstrates high cellular activity, excellent selectivity, and is used as an in vitro probe. | ||
| S5282 | Lactitol monohydrate | Lactitol is an artificial sugar alcohol currently used as a bulk sweetener in calorie-controlled foods. | ||
| S5467 | Asarinin | Asarinin (Sesamin, Fagarol, Pseudocubebin, Episesamin, Eleutheroside B4), isolated as a racemate from the shrub Zanthoxylum alatum, is usually used as a dietary fat-reduction supplement. | ||
| S9195 | Maltotetraose | Maltotetraose, found in many foods, belongs to the class of organic compounds known as oligosaccharides. | ||
| S6245 | N-Acetylglutamic acid | N-Acetylglutamic acid (N-Acetylglutamate) is the first intermediate involved in the biosynthesis of arginine in prokaryotes and simple eukaryotes and a regulator in the process known as the urea cycle that converts toxic ammonia to urea for excretion from the body in vertebrates. | ||
| S2991 | Thiamine monophosphate chloride dihydrate | Thiamine monophosphate chloride dihydrate (Vitamin B1 Monophosphate Chloride, Sineurina, Phosphothiamine) is an endogenous metabolite. |
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| E0158 | N-Nitroso-N-methylurea | N-Nitroso-N-methylurea (NMU, MNU, NMH, 1-Methyl-1-nitrosourea, N-Methyl-Nnitrosourea, Methylnitrosourea) is a highly reliable carcinogen, mutagen, and teratogen.N-Nitroso-N-methylurea can be used to induce animal models of Breast Carcinoma. | ||
| S5308 | 7-(Diethylamino)coumarin-3-carboxylic acid | 7-(Diethylamino)-coumarin-3-carboxylic acid (7-DCCA) has been used as a laser dye, fluorescent label, and biomedical inhibitor in many different applications. | ||
| S5455 | Akebia saponin D | Akebia saponin D (Asperosaponin VI), the most abundant constituent of the rhizome of Dipsacus asper, has been used for the treatment of lower back pain, traumatic hematoma and bone fractures. | ||
| S6247 | Senecioic acid | Senecioic acid (3-Methylcrotonic acid, 3,3-Dimethylacrylic acid, β-Methylcrotonic Acid) is an unsaturated fatty acid found in the pheromones of mealybug species and appears in the urine of patients with 3-Methylcrotonic aciduria. | ||
| S2992 | Sodium mesoxalate monohydrate | Sodium mesoxalate monohydrate (sodium 2,2-dihydroxymalonate) is an endogenous metabolite. |
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| E0149 | Papain | Papain (papaya proteinase I) is a sulfhydryl protease from the latex of the papaya fruit. Papain breaks down intercellular matrix of cartilage.Papain can be used to induce animal models of Emphysema. | ||
| E0195 | Potassium phosphate dibasic | Potassium phosphate dibasic (Dipotassium phosphate, K2HPO4) is often used as a fertilizer, food additive, and buffering agent. | ||
| E1915New | DDO-2728 | DDO-2728 is a selective pyrazolopyrimidine-based inhibitor of ALKBH5 with an IC50 of 2.97 μM. It increases the levels of N6-methyladenosine (m6A) modifications in acute myeloid leukemia (AML) cells and exhibits antiproliferative activity in these cells. It also demonstrates anti-tumor efficacy in the MV4−11 xenograft model. | ||
| S5306 | Forchlorfenuron (CPPU) | Forchlorfenuron (CPPU) is a synthetic cytokinin that inhibits septins and exhibits anti-parasitic, anticancer, and anti-angiogenic activities. | ||
| S6632 | Mirogabalin (DS-5565) | Mirogabalin (DS-5565) is a novel, preferentially selective α2δ-1 ligand that has been used in trials studying the treatment of Post-herpetic Neuralgia, Pain Associated With Fibromyalgia, and Diabetic peripheral neuropathic pain. | ||
| S2993 | D-Saccharic acid potassium salt | D-Saccharic acid potassium salt (D-Glucaric acid potassium, Potassium bisaccharate) is an endogenous metabolite. |
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| E0156 | Thioacetamide | Thioacetamide (TAA) is a hepatotoxin frequently used for experimental purposes which produces centrilobular necrosis after a single dose administration.Thioacetamide can be used to induce animal models of Cirrhosis. | ||
| E0166 | Potassium phosphate monobasic | PoPotassium phosphate monobasic (Monopotassium phosphate) is a commonly used in biological assay buffers. Potassium phosphate monobasic is moderate to highly concentrated aqueous solutions of potassium phosphate monobasic for the production of phosphate buffers and other laboratory applications. Potassium phosphate monobasic (KH2PO4) also used as a fertilizer, food additive, and buffering agent. | ||
| E2361 | KR-33494 | KR-33494 is a potent inhibitor of Fas-mediated cell death (FAF1). | ||
| E4041 | Deuterium oxide | Deuterium oxide (D2O, heavy water), also known as heavy water, is a stable and non-radioactive isotopic form of water widely used in high-resolution NMR studies. It also serves as a safe and inexpensive source of deuterium (D) for D/H exchange reactions. | ||
| E6003New | Gabapentin enacarbil | Gabapentin enacarbil (XP13512) is a prodrug of gabapentin, designed to enhance gabapentin absorption and bioavailability and treats restless legs syndrome. It also acts as an anticonvulsant and analgesic within the gabapentinoid class. | ||
| S5102 | Stachyose | Stachyose is a natural sugar found in many foods like beans and vegetables. | ||
| S5673 | Mivacurium chloride | Mivacurium chloride is a rapid, non-depolarising, neuromuscular blocking agent of short duration, used therefore as anesthetic, to provide skeletal muscle relaxation in minor surgical operations, in emergency surgical procedures of short to intermediate duration and during intubation of the trachea. | ||
| S6251 | Terephthalic acid | Terephthalic acid (para-Phthalic acid, 1,4-Benzenedioic acid), a raw material for polyethylene terephthalate (PET) production, is one of the most important chemicals in petrochemical industry.Terephthalic acid can be used to induce animal models of Bladder Urolithiasis . | ||
| S2999 | Acetic acid octyl ester | Acetic acid octyl ester (Octyl acetate) is one of the major components of essential oils in the vittae, or oil tubes, of the wild parsnip (Pastinaca sativa). Acetic acid octyl ester exhibits antioxidant activity. |
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| E1022 | 7,12-Dimethylbenz[a]anthracene (DMBA) | 7,12-Dimethylbenz[a]anthracene (DMBA) is an immunosuppressor as well as a potent organ-specific carcinogen. | ||
| E0179 | Aluminum potassium sulfate | Aluminum potassium sulfate (APS) and tannic acid (ALTA) sclerotherapy are often used to treat hemorrhoids. Aluminum potassium sulfate induces learning and memory deficits in mice. | ||
| S6252 | 3-Hydroxypicolinic acid | 3-Hydroxy picolinic acid is a picolinic acid derivative and is a member of the pyridine family. It is used as a matrix for nucleotides in MALDI mass spectrometry analyses | ||
| S6501 | NVP 231 | NVP 231 is a novel CerK inhibitor that inhibits the catalytic activity of recombinant CerK in vitro with an IC50 of 12 nM. | ||
| S3006 | Methyl isoeugenol | Methyl isoeugenol (Methylisoeugenol) is an eugenol analogue isoeugenol isolated from Acori Tatarinowii Rhizoma. Methyl isoeugenol is a highly attractive lure for Z. diversus and would be a valuable inclusion as an attractant in monitoring and male annihilation programs. |
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| E0154 | Taurocholic acid sodium salt | Taurocholic acid sodium salt (Sodium Taurocholate, TANa) is a sodium salt of taurocholic acid and occurs in the bile of mammals. Taurocholic acid is used as a cholagogue and choleretic. | ||
| E2945 | TMRM Perchlorate | TMRM Perchlorate (T668) is a membrane-permeant, cationic, fluorescent dye that can label mitochondria and mark embryonic stem cell/induced pluripotent stem cell-derived cardiomyocytes. It is useful for the isolation of mature cardiomyocytes. It is also used as a sensitive probe for the detection of mitochondrial membrane potential. | ||
| E4021 | 3-(Trimethoxysilyl)propyl methacrylate | 3-(Trimethoxysilyl)propyl methacrylate (TMPSM) is a reactive monomer and silane coupling agent. It is widely used in thepreparation and fabrication of organic/inorganic hybrid nanomaterials. | ||
| E7016New | Ac-DEVD-AFC | Ac-DEVD-AFC is a fluorogenic substrate specifically measures the activity of caspase-3, a key protease involved in apoptosis. | ||
| S3613 | Scoparone | Scoparone (6,7-dimethoxycoumarin, Aesculetin dimethyl ether, 6,7-Dimethylesculetin, Escoparone) is a natural organic compound discovered from Chinese herb Artemisia scoparia with anticoagulant, hypolipidemic, vasorelaxant, antioxidant, and anti-inflammatory actions. | ||
| E0139 | ALC-0315 | ALC-0315 is an ionisable aminolipid that is responsible for mRNA compaction and aids mRNA cellular delivery and its cytoplasmic release through suspected endosomal destabilization. | ||
| E2194 | Skimmianine | Skimmianine, a furoquinoline alkaloid present mainly in the Rutaceae family, with antispastic, anti-inflammatory activities and antiplatelet aggregation effect, exhibits cytotoxicity against a variety of cancer cell lines and genotoxicity. | ||
| S4577 | Terpin hydrate | Terpin hydrate is an expectorant, commonly used to loosen mucus in patients presenting with acute or chronic bronchitis, and related conditions. | ||
| S5148 | 2-Methylenebutyrolactone | 2-Methylenebutyrolactone (Tulipalin A, MBL, α-methylene-γ-butyrolactone), also known as α-methylene-γ-butyrolactone (MBL) (Tulipalin A), belongs to the class of sesquiterpene lactone family and is considered as cyclic analog of most common vinyl monomer methyl methacrylate (MMA). | ||
| S5161 | 1-Octacosanol | 1-Octacosanol (n-Octacosanol, Octacosyl alcohol, Octanosol, Montanyl alcohol, Cluytyl alcohol) is a straight-chain aliphatic 28-carbon primary fatty alcohol that is used as a nutritional supplement. It is reported to possess cholesterol-lowering effects, antiaggregatory properties, cytoprotective use, and ergogenic properties. | ||
| S6256 | Isocytosine | Isocytosine (2-aminouracil) is an isomer of cytosine used in physical chemical studies involving metal complex binding, hydrogen-bonding, and tautomerism and proton transfer effects in nucleobases. | ||
| S0506 | GJ103 sodium salt | GJ-103 sodium salt is an active analog of the read-through compound GJ072. | ||
| S3091 | Methyl acetoacetate | Methyl acetylacetate (MAA, Acetoacetate methyl ester, Methyl 3-oxobutanoate, Methyl 3-oxobutyrate, Methyl acetoacetate, Methyl acetylacetate), an endogenous metabolite, is used as a chemical reagent used in the synthesis of pharmaceuticals. |
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| E1209 | WAY-309236-A | WAY-309236-A is a bioactive compound. | ||
| E4029 | Tyramine hydrochloride | Tyramine Hydrochloride is a hydrochloride salt of the naturally occurring monoamine derived from the amino acid tyrosine. Tyramine acts as a catecholamine-releasing agent but cannot cross the blood-brain barrier. | ||
| E1685 | D609 | D609 is a selective, competitive inhibitor of phosphatidylcholine-specific phospholipase C (PC-PLC) with a Ki of 6.4 μM. It is an antioxidative protector and has antiviral and anti-inflammatory activity and also inhibits angiogenesis by preventing the synthesis of basement membrane (BM). | ||
| S5147 | 1,3,5-Trimethylpyrazole | 1,3,5-Trimethylpyrazole (1,3,5-TMePz; 1,3,5-Trimethyl-1H-pyrazole) is an intermediate product used for chemical synthesis. | ||
| S5172 | 1-Triacontanol | 1-Triacontanol (n-Triacontanol, Melissyl alcohol, Myricyl alcohol) is a fatty alcohol found in plant cuticle waxes and in beeswax. It is a growth stimulant for many plants, most notably roses. | ||
| S9356 | 7,8-Dihydroxy-4-phenylcoumarin | 7,8-Dihydroxy-4-phenylcoumarin is an intermediate. | ||
| S6257 | N-Acetylglucosamine | N-Acetylglucosamine (GlcNAc) is a monosaccharide that usually polymerizes linearly through (1,4)-β-linkages. It may be helpful for the treatment of autoimmune diseases. | ||
| S0014 | HT-2157 | HT-2157 (SNAP37889) is a selective, high-affinity, competitive antagonist of galanin-3 receptor (Gal3). | ||
| S2998 | Isophorone | Isophorone (IPHO), an α,β-unsaturated cyclic ketone, is a clear liquid with a camphor-like odor. Isophorone is used as a precursor to polymers. |
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| E0401 | BI6015 | BI6015, a <b>hepatocyte nuclear factor 4α (HNF4α)</b> antagonist, induces loss of HNF4α expression and hepatic steatosis in vivo. BI6015 is cytotoxic to human hepatocellular carcinoma (HCC). |
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| E1389 | Eeyarestatin I | Eeyarestatin I is a potent inhibitor of endoplasmic reticulum-associated protein degradation (ERAD). Eeyarestatin I also inhibits Sec61 translocon. | ||
| E4024 | Poly-D-lysine hydrobromide | Poly-D-lysine hydrobromide is a synthetic polymeric substrate most widely used in neural cell culture. It removes proteinase K-resistant PrP from prion-infected SN56 neuroblastoma cells without affecting PrPC. | ||
| S5143 | Citropten | Citropten (5,7-Dimethoxycoumarin, Citroptene, Limettin, Limetin) is a natural organic compound which belongs to coumarins and derivatives class. | ||
| S5681 | Vinburnine | Vinburnine ((-)-Eburnamonine, Vincamone, L-Eburnamonine) is a vasodilator. It is a vinca alkaloid and a metabolite of vincamine. | ||
| S9206 | Hydroprotopine | Hydroprotopine (W1171) is a kind of natural herbal extract. | ||
| S3313 | Nudifloric Acid | Nudifloric acid (1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid), isolated from Cordyceps bassiana, which is one of Cordyceps species with anti-oxidative, anti-cancer, anti-inflammatory, anti-diabetic, anti-obesity, anti-angiogenic, and anti-nociceptive activities. |
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| E4042 | 5,5-Dimethyl-1-pyrroline N-oxide | 5,5-Dimethyl-1-pyrroline N-oxide (DMPO) is a cell-permeable hydrophilic spin trap agent for superoxide detection. It acts as a neuroprotective agent and incubating lymphocytes with DMPO decreases DNA damage by NiCl2. | ||
| S6261 | 2-Acetylpyrazine | 2-Acetylpyrazine is one of the volatile flavor constituents in popcorn, wheat and rye bread crust. | ||
| S3230 | L-Fucitol | L-Fucitol (1-Deoxy-D-galactitol), a galactitol analogue isolated from Myristica fragrans (Nutmeg), inhibits galactitol-positive strains of Escherichia coli K12. | ||
| S3317 | cis-3-Hexenyl hexanoate | Cis-3-Hexenyl hexanoate ((Z)-3-hexenyl hexanoate) is a kind of plant volatile that brings tropical and pulpy profile with citrus and green nuances to all kinds of fruit flavors. |
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| E4035 | Ficoll(R) 400 | Ficoll(R) 400 (sucrose-epichlorohydrin copolymer) is a macromolecular crowder that plays a pivotal role in promoting liquid-liquid phase separation (LLPS) of proteins. It is currently utilized in the isolation of serum and peripheral blood mononuclear cells (PBMC) from the whole blood of Parkinson's disease (PD) patients. | ||
| S5142 | D-(+)-Melezitose | Melezitose (D-Melezitose, (+)-Melezitose, D-melicitose, (+)-melicitose, melicitose) is a nonreducing trisaccharide sugar that is produced by many plant sap eating insects. | ||
| S9454 | Undecanoic acid | Undecanoic acid (Undecylic acid) is a medium chain length monocarboxylic acid that appears to be involved in the control of triacylglycerol synthesis. | ||
| S6262 | Ammonium formate | Ammonium Formate is the ammonium salt of formic acid. It is widely used in various organic reactions. | ||
| S3327 | Disodium 5'-inosinate monohydrate | Disodium 5'-inosinate monohydrate (Inosine 5'-monophosphate disodium salt hydrate) is an endogenous metabolite. |
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| E0454 | ARN-19702 | ARN19702 is an orally active, reversible N-Acylethanolamine acid amidase(NAAA) inhibitor (IC50 on human NAAA = 230 nM) that produces remarkable protective effects against multiple sclerosis in mice. | ||
| E4038 | Cyclic AMP sodium | Cyclic AMP Sodium (Cyclic adenosine monophosphate sodium, Adenosine cyclic 3', 5'-monophosphate sodium) is an adenosine triphosphate derivative and an intracellular signaling molecule responsible for directing cellular responses to extracellular signals. It plays a crucial role as a second messenger in numerous biological processes. | ||
| S3953 | L-Lysine hydrochloride | L-Lysine hydrochloride is an essential amino acid. It is often added to animal feed used as a dietary supplement and plays a major role in calcium absorption, building muscle protein, recovering from surgery or sports injuries, and the body's production of hormones, enzymes, and antibodies. | ||
| S5145 | Protoporphyrin IX (PPIX) | Protoporphyrin IX (PPIX) is a heterocyclic organic compound, which consists of four pyrrole rings, and is the final intermediate in the heme biosynthetic pathway. | ||
| S5053 | Imazalil | Imazalil (Enilconazole, Chloramizole) is a fungicide widely used in agriculture, also used in veterinary medicine as a topical antimycotic. | ||
| S5325 | Nitisinone (NTBC) | Nitisinone (NTBC) is a synthetic reversible inhibitor of 4-hydroxyphenylpyruvate dioxygenase used in the treatment of hereditary tyrosinemia type 1. | ||
| S9452 | 10-Undecenoic acid | 10-Undecenoic acid, a natural or synthetic fungistatic fatty acid, is used for the preparation of active pharmaceutical ingredients, cosmetics, perfumes, antidandruff shampoos and antimicrobial powders. | ||
| S9209 | Tritetradecanoin | Tritetradecanoin, found in Myristica fragrans Houtt., is used as an antiadhesion agent and lubricating agent. | ||
| S6264 | Rutin hydrate | Rutin (Quercetin-3-O-rutinoside, Rutoside, Sophorin) is a glycoside found in a wide variety of plants including citrus fruit. | ||
| S3333 | (2R,3R)-(-)-2,3-Butanediol | (2R,3R)-(-)-2,3-Butanediol ((2R,3R)-Butane-2,3-diol) is an endogenous metabolite. |
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| S5141 | Pyrithioxin | Pyrithioxin (Bonifen, Encefabol, Pyritinol, Vitamin B6 disulfide) is a neurotropic agent which reduces permeability of blood-brain barrier to phosphate. It has no vitamin B6 activity. | ||
| S5037 | Phenazine methosulfate | Phenazine methosulfate (N-Methylphenazonium methosulfate, 5-Methylphenazinium methyl sulfate) is widely used as an intermediate electron carrier for coupling the production of NADH or NADPH to the reduction of tetrazolium salts to coloured formazans. | ||
| S9210 | Ginsenoside Rk1 | Ginsenoside Rk1, one of the main elements of Sung Ginseng, has been confirmed as a new endothelial barrier enhancer recently and has anti-cancer activity. | ||
| S5178 | 4-Hydroxy-2,5-dimethyl-3(2H)furanone | 4-Hydroxy-2,5-dimethyl-3(2H)furanone (furaneol, HDMF) is a naturally occurring substance found in a variety of fruits and has been shown to have antimicrobial activity. | ||
| S6267 | Dodecanedioic acid | Dodecanedioic acid is a dicarboxylic acid mainly used in antiseptics, top-grade coatings, painting materials, corrosion inhibitors, surfactants, and engineering plastics. | ||
| S2990 | Dihydroxyfumaric acid hydrate | Dihydroxyfumaric acid hydrate (DHF) is an endogenous metabolite. The diester derivative of dihydroxyfumaric acid hydrate (DHF) has been used exclusively as an electrophile in organic synthesis. |
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| E2511 | ZINC05007751 | ZINC05007751 is a potent NIMA-related kinase NEK6 inhibitor with an IC50 of 3.4 μM, shows antiproliferative activity against a panel of human cancer cell lines and displays a synergistic effect with Cisplatin and Paclitaxel in a BRCA2 mutated ovarian cancer cell line. | ||
| E2995 | Formamide deionized | Formamide deionized(Methanamide, Formimidic acid) is a clear liquid amide derived from formic acid that serves as an essential solvent for catalytic hydrogenation reactions and acts as a reagent in the creation of diverse organometallic compounds. | ||
| E4432 | 3,3-Dimethyl-1-butanol | 3,3-Dimethyl-1-butanol (Neohexanol) is an orally active inhibitor of trimethylamine (TMA) and trimethylamine N-oxide (TMAO). 3,3-dimethyl-1-butanol negatively inhibits the signalling pathways of p65 NF-κB and TGF-β1/Smad3. 3,3-dimethyl-1-butanol has potential applications in cardiovascular disease (CVD). | ||
| S5132 | Casanthranol | Casanthranol is a purified mixture of te antranol glycosides derived from Cascara sagrada. | ||
| S5013 | Ioversol | Ioversol is an organoiodine compound used as a radiographic contrast agent. | ||
| S5264 | L-5-Methyltetrahydrofolate calcium | Calcium L-5-methyltetrahydrofolate (L-5-MTHF-Ca) is a synthetic derivative of folic acid, the predominant, naturally occurring form of folate. | ||
| S9211 | Eriocitrin | Eriocitrin (eriodictyol 7-rutinoside, Eriodictyol glycoside, Eriodictioside) is a flavone glycoside mainly found in lemon with antioxidant activity. | ||
| S6269 | Leucomalachite green | Leucomalachite green is a chief metabolite of malachite green, a triphenylmethane dye. It is one of the most commonly used reagents for presumptive blood test and gives a characteristic green color in the presence of blood. | ||
| S0727 | KUN50259 (DAAO inhibitor-1) | KUN50259 (DAAO inhibitor-1, Compound 35) is a potent inhibitor of D-amino acid oxidase (DAAO) with an IC50 of 0.12 μM. | ||
| S0926 | Tenuifoliside A | Tenuifoliside A isolated from Polygala tenuifolia, has anti-apoptotic and antidepressant-like effects. Tenuifoliside A exhibits its neneurotrophic effects and promotes cell proliferation through the ERK/CREB/BDNF signal pathway in C6 cells. | ||
| S2988 | DL-5-Hydroxylysine hydrochloride | DL-5-Hydroxylysine hydrochloride, an endogenous metabolite, is a racemic mixture of D- and L- enantiomers of 5-hydroxylysine which may be used as potential target markers for radical-induced protein oxidation. |
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| E0197 | 2-Acetamidofluorene | 2-Acetamidofluorene (2-AAF, 2-Acetaminofluorene, N-2-Fluorenylacetamide, N-Acetyl-2-aminofluorene) is a carcinogenic and mutagenic compound. |
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| E1503 | TRC102 (methoxyamine hydrochloride) | TRC102 (methoxyamine hydrochloride, O-Methylhydroxylamine hydrochloride) is a reagent used for the preparation of O-methyl oximes or the synthesis of O-methyl oximes from aldehydes. | ||
| S9212 | Melamine | Melamine (Cyanuramide, Cyanurotriamide) is a widely-used intermediate, mainly employed as a raw material for producing melamine resin and is a chemical most often found in plastic materials. | ||
| S5877 | 2-Phenylimidazole | 2-Phenylimidazole (PhI, 2-Phenyl-1H-imidazole) is a corrosion inhibitor for brass and can be used to prepare complex compounds with ruthenium(III). | ||
| S6271 | (S)-2-Hydroxy-3-phenylpropanoic acid | (S)-2-Hydroxy-3-phenylpropanoic acid (L-(-)-3-Phenyllactic acid, (2S)-2-Hydroxy-3-phenylpropanoic acid) is a valuable building block in the pharmaceutical and chemical industry—has recently emerged as an important monomer in the composition of the novel degradable biocompatible material of polyphenyllactic acid. | ||
| E2635 | Bicinchoninic acid disodium salt | Bicinchoninic acid disodium salt is used for determination of reducing sugar and protein though Copper. | ||
| E4443 | S-Nitrosoglutathione | S-nitrosoglutathione (GSNO, RVC-588, S-Nitroso-L-glutathione,Nitrosoglutathione) is an amino acid and nitric oxide donor that, under physiological conditions, spontaneously releases nitric oxide. S-nitrosoglutathione (GSNO) selectively inhibits platelet and NF-κB activation. It induces apoptosis in T cells in low concentrations (< 0.6 mM) while protecting T cells from apoptosis in higher concentrations (1-2 mM). | ||
| S3099 | δ-Valerolactone | δ-Valerolactone (Tetrahydro-2H-pyran-2-one, 5-Valerolactone, oxan-2-one) is an endogenous metabolite. |
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| E2674 | CP-24879 hydrochloride | CP-24879, an aniline derivative, is a potent, selective inhibitor of Delta(5)/Delta(6) desaturase. | ||
| E2636 | EDC hydrochloride | EDC hydrochloride (1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, EDC·HCl) is a carbodiimide reagent that can form nucleic acid and compounds with amide bonds. | ||
| E4034 | Fluorescent Brightener 28 | Fluorescent Brightener 28 (Tinopal UNPA-GX) is a viability stain used for identification of structure chitin and fungi. It is also used as a fluorescent brightening agent for cellulose and polyamide fabrics, paper and in detergents and soaps. | ||
| S5150 | Phytosterols | Phytosterols, also called plant sterols or stanol esters, are specialized compounds found in plants that are structurally similar to cholesterol found in humans. | ||
| S5414 | Diflucortolone valerate | Diflucortolone valerate (Afusona, Diflucortolone 21-valerate) is a potent corticosteroid esterified with valeric acid. It helps reduce swelling, itching, and redness. | ||
| S9214 | Jujuboside B | Jujuboside B, one of the saponins isolated from the seeds of Zizyphus jujuba var. spinosa, is used in traditional chinese medicine for treating cardiovascular diseases and neurodegenerative diseases. | ||
| S3328 | N-Formyl-L-methionine | N-Formyl-L-methionine (For-Met-OH) is an endogenous metabolite. |
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| E0196 | Alloxan Monohydrate | Alloxan Monohydrate is the most popular diabetogenic agents used for assessing the antidiabetic or hypoglycemic capacity of test compounds. Alloxan Monohydrate can be used to induce animal models of Diabetes Mellitus. |
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| E2637 | N-Ethyl-N-(2-hydroxy-3-sulfopropyl)-3-toluidine | N-Ethyl-N-(2-hydroxy-3-sulfopropyl)-3-toluidine (TOOS) is a chromogenic agent used for catalase spectrophotometric determination. | ||
| E1602 | Lotiglipron | Lotiglipron (PF-07081532) is an orally active GLP-1R agonist. It reduces glucose and body weight, and has the potential to be used in Type 2 diabetes mellitus (T2DM) research. | ||
| S5128 | Orsellinic acid ethyl ester | Orsellinic acid (Ethyl Orsellinate), a phenolic acid, is of importance in the biochemistry of lichens, from which it can be extracted. | ||
| S5765 | Sodium Dehydrocholate | Sodium Dehydrocholate is a semisynthetic bile acid made from cholic acid. It has been used for stimulation of biliary lipid secretion. | ||
| S6280 | Methyl 3-indolyacetate | Methyl 3-indolyacetate is a phytohormone. | ||
| E0152 | L(+)-Monosodium glutamate monohydrate | L(+)-Monosodium glutamate monohydrate (MSG monohydrate, L-Glutamic acid monosodium salt monohydrate, Monosodium L-glutamate monohydrate, Monosodium L-glutamate monohydrate) is a widespread nutritional additive and flavoring agent. L(+)-Monosodium glutamate monohydrate can lead to oxidative stress-mediated DNA damage and apoptosis. L(+)-Monosodium glutamate monohydrate can be used to induce animal models of Obesity. |
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| E2638 | Tricine | Tricine (N-[Tris(hydroxymethyl)methyl]glycine) is a buffer component for separation of low molecular weight peptides. | ||
| S5011 | Disodium Phosphate | Disodium Phosphate (Sodium hydrogen phosphate, Sodium phosphate dibasic) is an inorganic compound used usually as food additives. It is also functions as a corrosion inhibitor. | ||
| S0275 | DLin-KC2-DMA | DLin-KC2-DMA is a useful lipid for lipid-based nanoparticle (LNP) delivery system. | ||
| S4512 | Aceglutamide | Aceglutamide (α-N-Acetyl-L-glutamine, N2-Acetylglutamine) is a psychostimulant, nootropic agent which functions as a prodrug to glutamine with improved potency and stability. | ||
| S4891 | 1-Aminohydantoin Hydrochloride | 1-Aminohydantoin Hydrochloride is a pharmaceutical and pesticide intermediate. | ||
| S9217 | Complanatuside | Complanatuside, a flavonoid compound isolated from Astragalus complanatus and Lysimachia christinae, has anti-inflammation, lipid-lowering and hepatoprotective effects. | ||
| S6283 | 3,3-Dimethylglutaric acid | 3,3-Dimethylglutaric acid (3,3-Dimethylpentanedioate) is a compound that has occasionally found in human urine. | ||
| S2986 | 9-Methoxycanthin-6-one | 9-Methoxycanthin-6-one is present in intact plant parts and in callus tissues of different explants with anti-tumour activity. |
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| E0199 | N-butyl-N-(4-hydroxybutyl) nitrosamine | N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN, OH-BBN) is a model compound that induces high-grade, invasive tumors in the urinary bladder. N-butyl-N-(4-hydroxybutyl) nitrosamine can be used to induce animal models of Bladder Carcinoma. |
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| S4015 | Cyclamic acid | Cyclamic acid (NSC 220327) in the form of its sodium or calcium salt is one of the most widely used artificial sweeteners. | ||
| S4514 | Acetylleucine | Acetylleucine (N-acetyl-L-leucine) is a drug used in the treatment of vertigo. | ||
| S5156 | 4-Methoxysalicylaldehyde | 4-Methoxysalicylaldehyde (2-Hydroxy-4-methoxybenzaldehyde), a naturally occurring product, has a range of industrial applications in the preparation of organic compounds, drugs and therapeutic agents. | ||
| S4984 | 2,2'-Cyclouridine | 2,2'-Cyclouridine is a research tool for antiviral and anticancer studies. | ||
| S9218 | Phytolaccagenin | Phytolaccagenin, a triterpenoid saponin, is the active component of Radix Phtolaccae. | ||
| S0026 | GET-73 | GET-73(Gamma hydroxybutyric acid analogue,GET 73,GHB analogue), a γ-hydroxybutyrate (GHB) analog, shows a neuroprotective role against ethanol-induced neurotoxicity in primary cultures of rat hippocampal neurons. | ||
| S3108 | 2,5-Dimethylpyrazine | 2,5-Dimethylpyrazine (NSC 49139) is an endogenous metabolite. |
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| S5154 | Tetrahydropiperine | Tetrahydropiperine (Cosmoperine), derived from piperine, can be used to treat convulsion, epilepsy, relieve pain, and control insects. | ||
| S6285 | 6-Hydroxynicotinic acid | 6-Hydroxynicotinic acid is widely used in the manufacture of industrial products. | ||
| E2806 | WAY-323096 | WAY-323096 is a bioactive compound. | ||
| E1288New | Inaxaplin | Inaxaplin (VX-147) is an orally active inhibitor of apolipoprotein L1 (APOL1) function. Inaxaplin binds to APOL1 and is useful in the treatment of APOL1-associated kidney disease. | ||
| S4954 | Djenkolic Acid | Djenkolic Acid (Jengkolic acid, Djenkolate, S,S'-Methylenebiscysteine) is a naturally occurring sulfur-containing amino acid extracted from djenkol beans. It is toxic to humans, often causing kidney failure. | ||
| S6286 | Tricarballylic acid | Tricarballylic acid (β-Carboxyglutaric acid, Propane-1,2,3-tricarboxylic acid) is an inhibitor of aconitase and therefore interferes with the Krebs cycle. | ||
| P1239New | ADH-1 | ADH-1, an antagonist of N-cadherin, blocks N-cadherin-mediated cell adhesion. It exhibits significant antitumor activity against N-cadherin-expressing cells in vitro assays. | ||
| E1966New | VVD-214 | VVD-214 (RO7589831, VVD-133214) is a synthetic allosteric inhibitor of WRN helicase. VVD-214 binds irreversibly to cysteine 727 on WRN, suppressing ATP hydrolysis and helicase activity. VVD-214 exhibits potent efficacy in inducing double-stranded DNA breaks, nuclear enlargement, and cellular apoptosis in cancers with high microsatellite instability (MSI). | ||
| E4936New | Larazotide acetate | Larazotide acetate(AT-1001), a synthetic peptide, is an antagonist of zonulin. It functions as a gut permeability regulator for the treatment of celiac disease. | ||
| S5155 | Raffinose | Raffinose (Melitose, Melitriose) is a complex carbohydrate, a trisaccharide composed of galactose, fructose, and glucose. It can be broken apart into galactose and sucrose via the enzyme alpha-galactosidase. | ||
| S4827 | Manganese chloride | Manganese chloride occurs in nature as the mineral. It is used as a precursor for other manganese compounds. | ||
| S5697 | Isopropamide Iodide | Isopropamide iodide is a long-acting quaternary anticholinergic drug used in the treatment of peptic ulcer and other gastrointestinal disorders. | ||
| S3305 | Medicagenic acid | Medicagenic acid (Castanogenin), a bioactive triterpenoid pentacyclic glycoside isolated from Herniaria glabra L., has low xanthine oxidase, collagenase, elastase, and tyrosinase inhibitory activity. | ||
| S3029 | Malonic acid | Malonic acid (MOA), one of the major dicarboxylic acids (DCAs) in aerosols, has been identified experimentally and computationally to be a strong acid. Malonic acid (MOA) acts as a mediate bridge for the formation of pure SA-A-based clusters. |
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| E4218 | L-Cysteine (hydrochloride hydrate) | L-Cysteine hydrochloride hydrate is an essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione, and taurine. L-Cysteine hydrochloride hydrate suppresses ghrelin and reduces appetite in rodents and humans. | ||
| S5943 | Bromhexine | Bromhexine is an expectorant/mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus | ||
| S6292 | (S)-2-Hydroxysuccinic acid | (S)-2-Hydroxysuccinic acid (L-Malic acid) is a naturally occurring isomer of malic acid, found mainly in sour and unripe fruits. | ||
| E0250 | Artemitin | Artemitin, a significant flavonol compound existing in Laggera pterodonta (DC.) Benth., Artemisia rupestris L, etc., possesses bioactivities of antioxidative, anti-inflammatory and antiviral. | ||
| E2833 | 1,5-Anhydro-D-glucitol | 1,5-Anhydro-D-glucitol (1,5-Anhydroglucitol, 1,5-AG) is a naturally occurring monosaccharide found in nearly all foods, supporting reliable evidences for early forecast and screening of diabetes mellitus. | ||
| S5125 | 5alpha-Cholestan-3-one | 5alpha-Cholestan-3-one (Coprostanone) is a substrate of cholestenone 5alpha-reductase. | ||
| S5555 | Pamabrom | Pamabrom is a diuretic agent. | ||
| S5277 | INCB032304 | INCB032304 is a pharmaceutical intermediate. | ||
| S6293 | 2,4-Dihydroxybenzoic acid | 2,4-Dihydroxybenzoic acid (β-resorcylic acid, p-Hydroxysalicylic acid) is a degradation product of cyanidin glycosides from tart cherries in cell cultures and a metabolite found in human plasma after cranberry juice consumption. | ||
| S3090 | trans-Aconitic acid | trans-Aconitic acid (TAA) is an abundant constituent in the leaves of Echinodorus grandiflorus, a medicinal plant used to treat rheumatoid arthritis in Brazil. |
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| E1908New | HRO761 | HRO761 is a potent, selective, allosteric inhibitor of Werner syndrome RecQ helicase (WRN). It binds at the interface of the D1 and D2 helicase domains, locking WRN in an inactive conformation, and demonstrates anti-proliferative effects specifically in microsatellite instability (MSI) cancer cells. | ||
| S5362 | Citicoline | Citicoline (CDP-choline, cytidine 5'-diphosphocholine) is a naturally occurring compound that acts as nutrient with a broad spectrum of benefits for conditions associated with symptoms of neurological dysfunction. As an endogenous compound, it is also an essential intermediate in the synthesis of cell membrane phospholipids and its formation is the rate-limiting step in phosphatidylcholine synthesis. | ||
| S5946 | Argireline | Argireline is an innovative neuropeptide widely applied topically on the skin. | ||
| S6294 | 1,3,5-Trimethoxybenzene | 1,3,5-Trimethoxybenzene (Phloroglucinol trimethyl ether, Sym-trimethoxybenzene, Trimethylphloroglucinol) is a potential biomarker of flavonoid intake in human. It is a human xenobiotic metabolite. | ||
| S0284 | GJ103 | GJ-103 is an active analog of GJ072 which is a read-through compound (RTC). Chemical-induced read through of premature stop codons might be exploited as a potential treatment strategy for genetic disorders caused by nonsense mutations. | ||
| S3101 | 2-Deoxy-D-ribose | 2-Deoxy-D-ribose (Thyminose, Deoxyribose) is an endogenous metabolite. |
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| S3490 | ML349 | ML349 is a potent and specific inhibitor ofacyl protein thioesterase 2(APT2)/lysophospholipase 2 (LYPLA2) with a Ki of 120 nM and IC50 of 144 nM respectively. It exhibits reduction in MCF10A and Snail cell proliferation. | ||
| E0198 | Pristane | Pristane (2,6,10,14-Tetramethylpentadecane, TMPD) is a natural saturated terpenoid alkane obtained primarily from shark liver oil that is widely used to induce tumorgenesis in mice and arthritis and lupus nephritis in rats.Pristane can be used to induce animal models of Systemic Lupus Erythematosus. | ||
| E4446 | S-(5'-Adenosyl)-L-methionine p-toluenesulfonate salt | S-(5′-Adenosyl)-L-methionine p-toluenesulfonate salt (AdoMet) is a methyl donor and cofactor for enzyme-catalyzed methylations including catechol O-methyltransferase (COMT) and DNA methyltransferases (DNMT). It has an anti-apoptotic activity and can be used for the treatment of depression, liver cirrhosis, cholestasis and degenerative joint disease. | ||
| E1982New | SOP1812 | SOP1812( QN-302), is a tetra-substituted naphthalene diimide (ND) derivative and selective inhibitor of G-quadruplex (G4) transcription. It shows great affinity to hTERT G4 and HuTel21 G4 with KD values of 4.9 and 28.4 nM, respectively. It binds to G-quadruplex DNA in cancer gene promoters region and shows strong anti-proliferative and anti-tumor activity in pancreatic cancer models. | ||
| E1672New | NMDI14 | NMDI14(DA-66137) is an inhibitor of nonsense-mediated RNA decay (NMD). NMDI14 disrupts the SMG7-UPF1 interactions and inhibits NMD. NMDI14 increases the stability and expression of NMD targeted mRNAs. | ||
| S3687 | Urea | Urea (Carbonyldiamide, Ureophil) is a highly soluble organic compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of protein catabolism and constitutes about one half of the total urinary solids. | ||
| S3962 | Dihydroactinidiolide | Dihydroactinidiolide is known to be a bioactive molecule in animals. It is a component of pheromones in insects, such as red fire ants and in mammals such as the Cat and the Red Fox. | ||
| S5226 | L-carnosine | L-carnosine (Karnozin) is an antioxidant naturally found in skeletal muscle, brain tissue, and the heart that protects cells against oxidative stress. | ||
| S9227 | Sinensetin | Sinensetin (Pedalitin Permethyl ether), a natural polymethoxylated flavone, has potent antiangiogenesis activity. | ||
| S6295 | 2-Methoxybenzoic acid | 2-Methoxybenzoic acid (o-Anisic acid) is a flavouring agent. | ||
| S0941 | 3,29-O-dibenzoyloxykarounidiol | 3,29-O-dibenzoyloxykarounidiol is a triterpenoid isolated from Trichosanthes kirilowii Maxim. | ||
| S3260 | 3'-hydroxy Puerarin | 3'-hydroxy Puerarin is an isoflavone isolated from Puerariae Lobatae Radix. | ||
| S3118 | L-Homoserine | L-Homoserine (L-Hse) is an important biosynthetic intermediate of threonine, methionine and lysine. |
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| S1730 | Indapamide | Indapamide is a non-thiazide sulphonamide diuretic compound, generally used in the treatment of hypertension, as well as decompensated cardiac failure. | ||
| S7363 | BRD7552 | BRD7552 is an inducer of transcription factor PDX1, which increases insulin expression. | ||
| S3963 | DL-Glutamine | DL-Glutamine (Glutamin, 2-amino-4-carbamoylbutanoic acid) is a non-essential amino acid present abundantly throughout the body and is involved in many metabolic processes. | ||
| S5368 | Lactitol | Lactitol is a versatile, reduced calorie sweetener derived from natural milk sugar, used in a wide variety of sweetening applications. | ||
| S5372 | Methyl Aminolevulinate Hydrochloride | Methyl Aminolevulinate (Aminolevulinic acid methyl ester Hydrochloride, Methyl 5-aminolevulinate Hydrochloride) is a prodrug that is metabolised to protoporphyrin IX used in photodynamic therapy. | ||
| S5934 | (-)-Fenchone | Fenchone is a constituent of absinthe and the essential oil of fennel. It is used as a flavor in foods and in perfumery. | ||
| S6297 | 4-Hydroxy-3-methylbenzoic acid | 4-Hydroxy-3-methylbenzoic acid is a normal organic acid identified in urine specimens from a healthy population. | ||
| E1788New | CQ211 | CQ211 is a cell penetrant, potent and selective inhibitor of RIOK2(Right open reading frame kinase 2) with a Kd of 6.1 nM. It effectively inhibits cancer cell proliferation and shows promising in vivo efficacy in mouse xenograft models. | ||
| E4592New | UGT8-IN-1 | UGT8-IN-1 is a brain-penetrable and orally active inhibitor of ceramide galactosyltransferase enzyme (UGT8). UGT8-IN-1 targets sulfatide metabolism resulting in ceramide-induced lethal mitophagy and subsequent cancer cell death in vitro, and reduces tumour growth in mutant Kras; Gnas allografts. | ||
| S3964 | Mucic Acid | Mucic Acid (Schleimsaure, Saccharolactic acid, Tetrahydroxyadipic acid, D-Glucaric acid, Galactaric acid) is the dicarboxylic sugar acid resulting from oxidation glactose with dilute nitric acid. It is a substrate of galactarate O-hydroxycinnamoyltransferase. | ||
| S4955 | Acetosyringone | Acetosyringone (Acetosyringenin) is a phenolic natural product with analgesic, antipyretic and anti-inflammatory actions. | ||
| S6300 | 1,4-Dichlorobenzene | 1,4-Dichlorobenzene (p-Dichlorobenzene, para-dichlorobenzene) is used as a disinfectant, pesticide, and deodorant. | ||
| S0287 | P7C3-A20 | P7C3-A20 is a highly active analogue of P7C3. P7C3-A20 is neuroprotective and promotes endogenous reparative strategies after TBI (Traumatic brain injury). | ||
| S0943 | Arenobufagin | Arenobufagin is a natural bufadienolide from toad venom and induces apoptosis and autophagy in human hepatocellular carcinoma cells through inhibition of PI3K/Akt/mTOR pathway. | ||
| S3123 | 3-Methyl-2-buten-1-ol | 3-Methyl-2-buten-1-ol (Prenol, Prenyl alcohol, Dimethylallyl alcohol) is an endogenous metabolite. |
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| E1184 | CFT7455 | CFT7455 is an orally active zinc finger transcription factors (IKZF1) (Ikaros) and IKZF3 (Aiolos) degrader. It binds with high affinity to the cereblon E3 ligase (Kd of 0.9 nM). It is used in the treatment of multiple myeloma & non-Hodgkin’s lymphoma. | ||
| E4469 | Sodium Montmorillonite | Sodium Montmorillonite is a layered clay mineral (2:1 phyllosilicate) that belongs to a class of the smectite group. It can be used for preparation of new drug delivery systems, especially for slow release of protonable drugs due to its high degree of surface area and high capacity for cation exchange. | ||
| E4834New | 12-Crown-4 | 12-crown-4(EOCT, Ethylene oxide cyclic tetramer) is an effective phase-transfer catalyst and complexing agent for lithium, facilitating the dissolution of lithium bis(trifluoromethanesulfonyl)imide (LiTFSI) without requiring acetonitrile. It selectively binds to lithium ions and forms stable complexes, significantly improving electrolyte conductivity in lithium batteries, and positively influencing ion mobility and overall battery performance. | ||
| S5591 | Ectoine | Ectoine ( THP(B)) is a natural amino acid derivate with membrane stabilizing and inflammation reducing capacities. It is produced by bacteria living under extreme harsh environmental conditions where it serves as osmoregulatory compatible solute. | ||
| S9230 | Vaccarin | Vaccarin, a major flavonoid glycoside found in Semen vaccariae, exhibits extensive biological activities including vascular endothelial cell protective effects. | ||
| S9118 | Beta-Asarone | Beta-Asarone, found in certain plants such as Acorus and Asarum, could pass the blood-brain barrier and exerts neuroprotection effects. | ||
| S6305 | Catechol | Catechol (Pyrocatechol, 1,2-dihydroxybenzene, 1,2-Benzenediol, 2-Hydroxyphenol, O-Benzenediol, O-Dihydroxybenzene) is an organic compound essentially used as building block.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing. | ||
| S0944 | Benzoylaconitine | Benzoylaconine (Isaconitine, Pikraconitin) is an alkaloid derived from the Chinese traditional medicine Radix Aconiti Lateralis Preparata (Fuzi). Benzoylaconitine inhibits production of IL-6 and IL-8 via MAPK, Akt, NF-κB signaling in IL-1β-induced human synovial cells. | ||
| E0353 | Potassium oxonate | Potassium oxonate (Oxonic Acid Potassium Salt) is a selectively competitive uricase inhibitor, produced hyperuricemia (HUA) in rodents. | ||
| E2811 | WAY-328133 | WAY-328133 is a bioactive compound. | ||
| E4470 | Potassium Chloride | Potassium chloride is an inorganic salt commonly used in fertilizer industry. It is also extensively used as a potassium supplement. | ||
| E4990New | 1-Butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide | 1-Butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide (BMIM TFSI) is a room-temperature ionic liquid with excellent ionic conductivity. Its solvation dynamics and conductivity are affected by proton concentration, which influences its performance in electrochemical applications. | ||
| S4873 | Dicyclanil | Dicyclanil is a pyrimidine-derived regulator of insect growth used for topical treatment of sheep to prevent larval infestation by the blowfly. | ||
| S5572 | Azetidine-2-carboxylic acid | Azetidine-2-carboxylic acid (L-Aze) is a toxic and teratogenic non-protein amino acid that is misincorporated into protein in place of proline, altering collagen, keratin, hemoglobin, and protein folding. | ||
| S6307 | 2-Methyllactic acid | 2-Methyllactic acid (2-Hydroxyisobutyric acid, Acetonic acid) is a metabolite of methyl tertiary-butyl ether. | ||
| E0162 | Cupric sulfate | Cupric sulfate (Copper(II) sulfate) is a salt formed by treating cupric oxide with sulfuric acid. Cupric sulfate is a lewis acid catalyst commonly used to promote acid-catalyzed organic transformations. | ||
| E0469 | GW 610 | GW 610 (NSC 721648), an antitumor agent, shows potent and selective anticancer activity against lung, colon, and breast cancer cell lines. | ||
| E2017 | Deoxypodophyllotoxin | Deoxypodophyllotoxin (DPT), a derivative of podophyllotoxin, is a lignin from Anthriscus sylvestris with potent antimitotic, anti-inflammatory and antiviral activities. | ||
| E2809 | WAY-328168 | WAY-328168 is a bioactive compound. | ||
| E4471 | Nonaethylene glycol Monododecyl ether | Nonaethylene glycol monododecyl ether is a non-ionic surfactant. It has been used to assess a procedure for analyzing total lipid and triacylglycerol using bovine liver tissue. | ||
| S5571 | L-Asparagine | L-Asparagine (2-Aminosuccinamic acid, alpha-aminosuccinamic acid) is a non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue. | ||
| S9232 | Crocin II | Crocin II (Crocin B, Crocetin gentiobiosylglucosyl ester, Tricrocin), a carotenoid chemical compound that is found in the flowers crocus and gardenia, is an antioxidant and neural protective agent. | ||
| S6308 | 4-Ethylphenol | 4-Ethylphenol (P-Ethylphenol, 4-Hydroxyphenylethane) is a phenolic compound produced in wine and beer by the spoilage yeast Brettanomyces. | ||
| S6493 | n-Butylidenephthalide | n-Butylidenephthalide ((Z)-Butylidenephthalide, 3-Butylidenephthalide, Butylidenephthalide), isolated from the chloroform extract of Angelica sinensis (AS-C), contributes to a range of biological activities, including diminution of angina, platelet aggregation, proliferation, non-specific spasmosis. | ||
| S3297 | Hosenkoside A | Hosenkoside A is a bioactive baccharane glycoside isolated from the seeds of impatiens balsamina. | ||
| E0466 | Adarotene | Adarotene (ST1926) causes a dose-dependent growth inhibition in a large panel of human tumor cell lines with IC50 ranging from 0.1 to 0.3 µM, causes cell accumulation in G1/S or S phase of cell cycle depending on tumor cells, exhibiting a potent antiproliferative activity. | ||
| E4940New | Chlorphenesin carbamate | Chlorphenesin carbamate(Maolate, Rinlaxer, U 19646) is a centrally-acting muscle relaxant that inhibits motoneuron excitability. It is also used to treat pain and discomfort related to skeletal muscle trauma and inflammation. | ||
| S5570 | Arachidic acid | Arachidic acid (eicosanoic acid, Icosanoic Acid) is a natural saturated fatty acid used for the production of detergents, photographic materials and lubricants. | ||
| S6309 | Methylguanidine HCl | Methylguanidine is a guanidine compound deriving from protein catabolism. | ||
| S0533 | TLX agonist 1 | TLX agonist 1 (CCRP2, SUN23314) is a modulator of orphan nuclear receptor tailless (TLX, NR2E1) with EC50 of 1.0 μM and Kd of 650 nM. TLX agonist 1 (CCRP2, SUN23314) binds to recombinant TLX protein and enhances TLX transcriptional repressive activity. | ||
| S3303 | Cyperotundone | Cyperotundone (CYT) is an active constituent in Chuanxiong Rhizoma and Cyperi Rhizoma (CRCR) for treating migraine. | ||
| E2810 | WAY-328178 | WAY-328178 is a bioactive compound. | ||
| E4829New | Bismuth subnitrate | Bismuth subnitrate is an antigastric ulcer and antidiarrheic agent that induces metallothionein (MT). It can be used as an adjunct in cancer chemotherapy to induce MT in target organs. | ||
| S4969 | Tropine | Tropine (Pseudotropine, 3alpha-Tropanol) is a naturally occurring tropane alkaloid that serves as an intermediate in the synthesis of a variety of bioactive alkaloids, many of which have potent neurological actions. | ||
| S5549 | DL-Arginine | Arginine is an α-amino acid that is used in the biosynthesis of proteins and plays an important role in cell division, wound healing, removing ammonia from the body, immune function, and the release of hormones. | ||
| S6316 | N-Acetyl-L-tyrosine | N-Acetyl-L-tyrosine is an acetylated form of the amino acid, L-Tyrosine. It is involved in catecholamine production. | ||
| E4464 | Hexythiazox | Hexythiazox is a selective acaricide with ovicidal, larvicidal and nymphicidal activities. It is widely used for chemical control of mites on cotton, fruits and vegetables. | ||
| E1698 | EN460 | EN460 is a small-molecule inhibitor of endoplasmic reticulum oxidation 1(ERO1), which is specific for the reduced active form of ERO1α and prevents re-oxidation. It also protects cells from erastin-induced ferroptosis. | ||
| S5544 | D-Ribose | D-ribose is a naturally occurring sugar involved in producing energy in the body and is also the structural basis of DNA and RNA. | ||
| S6317 | 2-Picolinic acid methyl ester | 2-Picolinic acid methyl ester (Methyl picolinate, 2-Pyridinecarboxylic acid methyl ester, Methyl pyridine-2-carboxylate) is used as pharmaceutical intermediate. | ||
| E4467 | Temozolomide Acid | Temozolomide acid is a carboxylic acid derivative of Temozolomide. It has an anticancer activity by causing breaks in DNA double strand, cell cycle arrest, and eventually cell death. | ||
| E4826New | L-Ornithine L-aspartate | L-ornithine-L-aspartate (LOLA) is a stable salt composed of two natural nonessential L-amino acids: ornithine and aspartic acid. It effectively lowers blood ammonia concentration by enhancing ammonia detoxification in the muscles, and alleviating hepatic encephalopathy symptoms in liver cirrhosis. | ||
| S9263 | 3-n-Butylphathlide | 3-n-Butylphathlide, initially isolated from the seeds of Apium graveolens Linn., has shown significant neuroprotective effects. | ||
| S6319 | 5-Methoxysalicylic acid | 5-Methoxysalicylic acid is a chemical compound belongs to the class of organic compounds known as m-methoxybenzoic acids and derivatives. | ||
| S6532 | kb-NB77-78 | kb-NB77-78 is an analog of CID797718. However, it shows no inhibitory activty towards PKD1. | ||
| E0159 | Colesevelam Hydrochloride | Colesevelam Hydrochloride is an orally administered, non-absorbable, polymeric, bile-acid-binding agent with a higher affinity for glycocholic acid in vitro. |
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| E0739 | 1-[(4R,5R)-4,5-Dihydroxy-L-ornithine]echinocandin B hydrochloride (1:1) | 1-[(4R,5R)-4,5-Dihydroxy-L-ornithine]-Echinocandin B Hydrochloride (Anidulafungin Nucleus) is used in the commercialization and late-stage development of a semisynthetic antifungal anidulafungin/D-fructose. | ||
| E4473 | Lactate | Lactate (Lactic acid) is the product of glycolysis, produced due to lack of oxygen in contracting skeletal muscle in vivo, and can be utilised under fully aerobic conditions. It plays a key role as a metabolic intermediate and can be used as hemodynamic marker and resuscitation endpoint in several cohorts of critically ill patients. | ||
| S3815 | Mogroside V | Mogroside V is a natural cucurbitane glycoside which has a sweetening strength of 250 times that of sucrose and is derived from mature fruit of luo-han-guo (Siraitia grosvenorii, monk fruit). | ||
| S4858 | Tryptophol | Tryptophol (Indole-3-ethanol) is an aromatic alcohol found as a secondary product of alcoholic fermentation that induces sleep in humans. | ||
| S5562 | 2-Hydroxybenzyl alcohol | 2-Hydroxybenzyl alcohol (Salicyl alcohol, Salicain, Diathesin, Saligenin, Saligenol, o-Methylolphenol, α,2-Toluenediol), which can be found in a number of food items such as red huckleberry, rye, jerusalem artichoke, and ceylon cinnamon, is precursor of salicylic acid and is formed from salicin by enzymatic hydrolysis by Salicyl-alcohol beta-D-glucosyltransferase or by acid hydrolysis. | ||
| S9238 | Polygalic acid | Polygalic acid (Senegenic acid), a triterpenoid saponin, shows expectorant, emetic and stimulant effects. | ||
| S9320 | Efetaal | Efetaal has a fresh floral hyacinth note with a suggestion of muguet and green leaves. | ||
| S6320 | 2,5-Furandicarboxylic acid | 2,5-Furandicarboxylic acid (Dehydromucic acid) is a normal urinary metabolite in humans and an important renewable building block because of its potential as a substitute for a variety of petrochemicals, such as terephthalic acid and adipic acid. | ||
| S3276 | Hosenkoside K | Hosenkoside K is a bioactive baccharane glycoside isolated from the seeds of impatiens balsamina. | ||
| E0160 | Hexaminolevulinate hydrochloride | Hexaminolevulinate hydrochloride (5-Aminolevulinic acid hexyl ester hydrochloride) is a tumour photosensitizer. |
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| E2389 | ML-098 | ML-098 is an activator of the GTP-binding protein Rab7 with an EC50 of 77.62 nM. | ||
| E4478 | Acetrizoic acid | Acetrizoic acid is a first monomeric, water-soluble, iodinated ionic compound used as an X-ray contrast agent having nephrotropic property that can be intravenously administered for clinical applications. | ||
| E4832New | DL-Alanine | DL-alanine (DL-2-Aminopropionic acid) is a racemic mixture of L- and D-alanine that forms complexes with transition metals like Cu(II), Zn(II), and Cd(II). It also plays a key role in the glucose-alanine cycle between tissues and the liver. | ||
| S5230 | Elubiol | Elubiol (dichlorophenyl imidazoldioxolan) is used as a cosmetic ingredient for the conditioning of oily skin, effective in oil control. | ||
| S4590 | Dithranol | Dithranol (Anthralin, cignoline, 1,8,9-trihydroxyanthracene) is one of the most important local therapeutic agents against the common skin disease, psoriasis. | ||
| S5854 | Xylometazoline | Xylometazoline (Ba-11391, Otrivine, Rhinoxilin) is a nasal vasoconstricting decongestant drug which is used to improve symptoms of nasal congestion, allergic rhinitis, and sinusitis. | ||
| S6323 | 2,6-Dimethoxybenzoic acid | 2,6-Dimethoxybenzoic acid is a polyphenol compound found in foods of plant origin. | ||
| E2136 | WAY-299775 | WAY- 299775 is a bioactive compound. | ||
| E1722 | Acetalax(Oxyphenisatin acetate) | Oxyphenisatin acetate is the pro-drug of oxyphenisatin. It has antiproliferative activity and also used to be a laxative. | ||
| E1947New | DiR (Cy7 DiC18) | DiR (Cy7 DiC18) is a near-infrared fluorescent long-chain carbocyanine dye used for labeling cell membranes, organelles, liposomes, viruses, and lipoproteins in vivo and in vitro. | ||
| E4830New | Guanidine thiocyanate | Guanidine thiocyanate is a potent inhibitor of nucleases and a powerful denaturant of proteins. It is used for RNA isolation due to its strong chaotropic properties, which effectively denature RNase enzymes in samples, ensuring RNA stability and purity during extraction processes. Nucleic acid extraction buffers containing guanidine thiocyanate effectively deactivate high-titer polioviruses found in potentially infectious materials. | ||
| S3818 | Tectoridin | Tectoridin (Shekanin), an isoflavone isolated from flowers of Pueraria thunbergiana, has several pharmacological effects including anti-cancer, anti-inflammatory, antioxidant, and hepatoprotectivy. | ||
| S5123 | Dihydrocholesterol | Dihydrocholesterol (Beta-Cholestanol, Zymostanol, 5alpha-Cholestanol) is a cholesterol derivative found in human feces, gallstones, eggs, and other biological matter. | ||
| S5367 | Ethyl Oleate | Ethyl Oleate (Oleic acid ethyl ester) is a fatty acid ester formed by the condensation of oleic acid and ethanol, usually used as a solvent for pharmaceutical drug preparations. | ||
| S6326 | D-3-Phenyllactic acid | D-3-Phenyllactic acid is a chiral building block that is used in preparation of statine. | ||
| S3381 | VUT-MK142 | VUT-MK142 is a potent new cardiomyogenic synthetic agent promoting the differentiation of pre-cardiac mesoderm into cardiomyocytes, which may be useful to differentiate stem cells into cardiomyocytes for cardiac repair. | ||
| A2129 | Anti-mouse Thy1.2 (CD90.2)-InVivo | Anti-mouse Thy1.2 (CD90.2)-InVivo(clone 30H12) is a monoclonal antibody reacts with mouse Thy1.2 also known as CD90.2. It induces Ca2+ flux in thymocytes and is particularly useful for depleting T lymphocytes. | ||
| S6426 | Hesperidin methylchalcone | Hesperidin methylchalcone is the Citrus original products with powerful antioxidant activity. | ||
| E0239 | (-)-Catechin gallate | (-)-Catechin gallate ((-)-CG) is a catechin polyphenol that has been found in green tea extracts with diverse biological activities. | ||
| S4949 | Nonanoic acid | Nonanoic acid (Pelargonic acid, Nonoic acid) is a naturally occurring fatty acid found in both vegetable and animal fats. | ||
| S5691 | Terpinyl Acetate | Terpinyl Acetate (alpha-Terpinyl), a naturally occuring compound found in several essential oils, is a flavouring agent. | ||
| S6009 | 1-Phenyl-1,2-propanedione | 1-Phenyl-1,2-propanedione (Acetyl benzoyl) is an eukaryotic metabolite produced during a metabolic reaction in plants. | ||
| S6332 | Nonadecanoic acid | Nonadecanoic acid (Nonadecylic acid, Nonadecanoate) is a long saturated fatty acid found in ox fats and vegetable oils, and in Staphylococcus. It can be used as a phermone by certain insects. | ||
| E0169 | Zinc acetate | Zinc acetate induces the expression of enterocyte metallothionein. |
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| E0240 | Procyanidin B1 | Procyanidin B1, a natural polyphenolic compound that has antioxidant properties, inhibits Kv10.1 channel and suppresses the evolution of hepatoma. |
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| S5616 | 4-Methylcatechol | 4-Methylcatechol (P-Methylcatechol, 3,4-Dihydroxytoluene, Homocatechol) is an inducer of nerve growth factor. It is used to synthesize antimicrobial and antioxidant. | ||
| S6012 | Methyloxalacetic acid diethyl ester | Methyloxalacetic acid diethyl ester (Diethyl 2-methyl-3-oxosuccinate, Diethyl methyloxobutanedioate, Diethyl oxalpropionate) is a member of the class of compounds known as beta-keto acids and derivatives. | ||
| S6333 | Undecanedioic acid | Undecanedioic acid (1,9-Nonanedicarboxylic acid, Undecanedionate) is a long-chain dicarboxylic acid that has applications in corrosion inhibitors, hot melt adhesives, high performance polyamides/Nylon, and more. | ||
| S9729 | Visomitin (SKQ1) | Visomitin (SKQ1) is a novel mitochondrial-targeted antioxidant that holds promise in the treatment of inflammation associated with ocular surface diseases such as dry eye disease (DED) and corneal wounds. SkQ1 shows a TC50 of 317 nM on HCjE cells. | ||
| E0241 | Asiaticoside B | Asiaticoside B is a triterpene glycoside isolated from Centella asiatica (L.) Urban, with anti-cancer activity. |
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| E1694 | Sardomozide dihydrochloride | Sardomozide dihydrochloride (CGP 48664A) is a potent inhibitor of S-adenosylmethionine decarboxylase (SAMDC) with an IC50 of 5 nM. It is also a potent inhibitor of polyamine oxidase and exhibits with broad spectrum antiproliferative and antitumor activity. | ||
| S5576 | Benzyl acetate | Benzyl acetate (Acetic acid benzyl ester, Benzyl ethanoate, Phenylmethyl), usually found in alcoholic beverages, is a flavouring agent. | ||
| S6335 | Ethyl maltol | Ethyl maltol (2-Ethyl-3-hydroxy-4H-pyran-4-one, 2-Ethyl pyromeconic acid) is a common flavourant in some confectioneries. | ||
| E0242 | Picrocrocin | Picrocrocin, the chemical most responsible for the bitter taste of saffron, is isolated from saffron and inhibits proliferation of cancer cells. | ||
| E1885New | LY3522348 | LY3522348 is a highly selective oral dual inhibitor of the human ketohexokinase isoforms C and A, with IC50 values of 20nM for hKHK-C and 24nM for hKHK-A. It shows a significant pharmacodynamic effect in a mouse model of fructose metabolism. | ||
| S3823 | Schizandrol A | Schizandrol A is one of the effective components in the dried fruit of Schizandra chinensis Bail and works by increasing dopamine, a neurotransmitter, in the brain. | ||
| S6024 | Ethyl acetoacetate | Ethyl acetoacetate, found in coffee and coffee products as well as in strawberry and yellow passion fruit juice, is a flavouring agent used as a chemical intermediate in the production of a wide variety of compounds. | ||
| S6338 | 3,4-Dihydroxyhydrocinnamic acid | 3,4-Dihydroxyhydrocinnamic acid (Dihydrocaffeic acid) is a metabolite product of the hydrogenation of caffeoylquinic acids, occurring in normal human biofluids, with potent antioxidant properties. | ||
| S8970 | HQNO | HQNO (2-heptyl-4-hydroxyquinoline-N-oxide) is a natural quinolone secreted by P. aeruginosa. HQNO is a potent inhibitor of the electron transport chain with Kd of 64 nM for the ubiquinol-ferricytochrome c oxidoreductase segment (Complex III) of the respiratory chain. HQNO is also an inhibitor of bacterial and mitochondrialType II NADH : quinone oxidoreductase (NDH-2) with IC50 of 7.3 μM in the presence of 50μM menadione. | ||
| E0243 | Emodin-8-glucoside | Emodin-8-glucoside (Emodin glucoside B, Anthraglycoside B, Emodin glucoside B) is an anthraquinone derivative isolated from Aloe vera, binds to minor groove of DNA. | ||
| S5597 | (1R)-(-)-Menthyl acetate | (1R)-(-)-Menthyl acetate is a natural monoterpene which contributes to the smell and flavor of peppermint. | ||
| S6029 | 4-Methyl-n-octanoic Acid | 4-Methyl-n-octanoic Acid is a flavouring ingredient. | ||
| S6339 | Black PN | Black PN (Brilliant Black BN) is a black dye that provides a blackish violet shade in applications. | ||
| E1889New | PCO371 | PCO371 is a nonpeptidyl, orally active agonist of Parathyroid hormone type 1 receptor (PTHR1). It stimulates cAMP production in COS-7 cells with an EC50 of 2.4 μmol/L. It also acts as an osteoporosis drug and significantly enhances bone mineral density (BMD) and bone strength in the lumbar vertebrae of osteopenic ovariectomized (OVX) rats. It also restores normal serum calcium levels without increasing urinary calcium in hypocalcemic thyroparathyroidectomized (TPTX) rats. | ||
| S3825 | Glycitin | Glycitin (Glycitein-7-β-O-glucoside), a natural isoflavone isolated from legumes, has antibacterial, antiviral and estrogenic activities and may exerts preventative effects on alcoholism, cardiovascular and cerebrovascular diseases and some types of cancer. | ||
| S5585 | Citronellal | Citronellal (Rhodinal, 2,3-Dihydrocitral), a monoterpenoid found in oil of citronella, lemon, and lemon grass, has insect repellent properties and is used in perfumes. | ||
| S5370 | 10-Hydroxydecanoic acid | 10-Hydroxydecanoic acid, a minor constituent of royal jelly, is a saturated fatty acid that has cytotoxic effects. | ||
| S9355 | 2,4'-Dihydroxybenzophenone | 2,4'-Dihydroxybenzophenone (DHBP) is an organic compound used for the synthesis of pharmaceutical agents. | ||
| S6037 | Methyl p-tert-butylphenylacetate | Methyl 4-tert-butylphenylacetate is a flavouring ingredient with a roasted, chocolate-like flavour. | ||
| S6343 | D-Glucuronic acid | D-Glucuronic acid (D-Glucopyranuronic Acid) is a key intermediate metabolite of the uronic acid pathway and may plays a role in the detoxification of certain drugs. | ||
| E0245 | Rhamnose | Rhamnose(L-Rhamnose) is an important 6-deoxy sugar present in many natural products, glycoproteins, and structural polysaccharides. | ||
| S6039 | 4-Ethyloctanoic acid | 4-ethyloctanoic acid is identified from flue-cured Virginia tobacco and is mainly used as daily flavor, food flavor, industrial flavor, nutrient, stabilizers, surfactants and emulsifiers. | ||
| S6344 | Tetradecanedioic acid | Tetradecanedioic acid (Tetradecanedicarboxylate) is a C14 dicarboxylic acid. | ||
| S3389 | Heptamidine Dimethanesulfonate | Heptamidine (SBi4211) Dimethanesulfonate is a novel and potent Pentamidine-related inhibitor of the calcium-binding protein S100B with a Kd of 6.9 μM. | ||
| E0246 | β-Anhydroicaritin | β-Anhydroicaritin is isolated from Boswellia carterii Birdware, has antiosteoporosis, estrogen regulation and antitumor properties. | ||
| E5841New | Acetyl phosphate(lithium potassium) | Acetyl phosphate(lithium potassium) is an endogenous metabolite, bypasses the LytS membrane potential sensor by phosphorylating LytR twice as fast, influencing lrgAB operon regulation in glucose-rich conditions without membrane potential disruption. Lithium potassium acetyl phosphate is studied for its electrochemical properties and role in phosphorus chemistry, with potential applications in lithium-ion battery technology and catalytic processes. | ||
| S4881 | Calcium Dobesilate | Calcium dobesilate (calcium dihydroxy-2,5-benzenesulfonate) is a small molecule that has been widely used for treating diabetic retinopathy and chronic venous insufficiency. | ||
| S5021 | Cefalexine EP IMpurity B | Cefalexine EP Impurity B (Cephalexin Impurity B, 7-ADCA, 7-Aminodesacetoxycephalosporanic acid, Deacetoxycephalosporanic Acid) is used in the synthesis of cephalosporins and for bioconversion studies. | ||
| S6040 | 2,3-Butanediol (mixture of isomers) | 2,3-Butanediol (Dimethylene glycol, 2,3-Dihydroxybutane, Butan-2,3-diol, 2,3-Butylene glycol) is an important microbial metabolite and has been widely used in many fields such as food, medicine, chemical, and so on. | ||
| S6346 | L-(+)-Arabinose | L-(+)-Arabinose (DL-Arabinose, Pectinose) is used as a substrate to identify, differentiate and characterize pentose sugar isomerase(s). | ||
| S0057 | N-Succinimidyl-S-acetylthioacetate (SATA) | N-Succinimidyl-S-acetylthioacetate (SATA) is a protein modification agent which introduces thiol-groups into protein molecules. N-Succinimidyl-S-acetylthioacetate (SATA) adds sulfhydryl groups to proteins and other amine-containing molecules in a protected form. | ||
| E0247 | Militarine | Militarine is a major chemical constituent of the tuber of Bletilla striata (Thunb.) Reichb.f., with a prominent neuroprotective effect. | ||
| S5483 | Tribenzagan Hydrochloride | Tribenzagan Hydrochloride (Trimethobenzamide) is an orally available, antiemetic agent used in the therapy of nausea and vomiting associated with medications and gastrointestinal, viral and other illnesses. | ||
| S5580 | Arabic gum | Arabic gum, derived from exudates of Acacia senegal or Acacia seyal trees, is a complex polysaccharide indigestible to both humans and animals and considered as a safe dietary fiber. | ||
| S6041 | Dibutyl sebacate | Dibutyl sebacate is an organic chemical which is mainly used as a plasticizer in the production of plastics. | ||
| S6348 | (+)-Delta-Tocopherol | (+)-Delta-Tocopherol (8-Methyltocol) is the orally bioavailable delta form of the naturally-occurring fat-soluble vitamin E, mostly found in soybean and corn oils, with potential antioxidant activity. | ||
| A2117 | Mouse IgG2a isotype control-InVivo | Mouse IgG2a isotype control-InVivo (Clone:C1.18.4) monoclonal antibody is ideal for use as a non-reactive isotype-matched control for mouse IgG2a antibodies in most in vivo and in vitro applications. | ||
| E0248 | Rehmannioside D (Rhmannioside D) | Rehmannioside D (Rhmannioside D) is an iridoid glycoside that has been found in Rehmannia glutinosa. | ||
| E1160 | C381 | C381 physically targets the lysosome, promotes lysosomal acidification, increases breakdown of lysosomal cargo, and improves lysosome resilience to damage. | ||
| E1995New | AZD-5462 | AZD-5462(Example 1) is a modulator of RXFP1, the cognate receptor for human relaxin, that belongs to the GPCR family 1c number. AZD-5462 exhibits anti-fibrotic and anti-inflammatory properties. | ||
| S4134 | Sevelamer Carbonate | Sevelamer carbonate is a non-absorbed phosphate binding crosslinked polymer, with the same polymeric structure as sevelamer hydrochloride, in which carbonate replaces chloride as the counterion. | ||
| S4868 | Xanthinol Nicotinate | Xanthinol Nicotinate (Complamin, Angioamin) is a potent vasodilator that can easily pass through the cell membrane and once inside the cell it causes an increase in glucose metabolism resulting in an increased energy. | ||
| S5642 | Homovanillic acid | Homovanillic acid (Vanillacetic acid) is a major catecholamine metabolite that is used as a reagent to detect oxidative enzymes, and is associated with dopamine levels in the brain. | ||
| S9253 | Coixol | Coixol (6-methoxybenzoxazolone, MBOA) acts as a central muscle relaxant with an anti-convulsant effect. | ||
| S6049 | (+)-(S)-Carvone | (+)-(S)-Carvone, a monoterpene found mainly in caraway and dill seed oils, is used in cosmetic, food and pharmaceutical preparations. | ||
| S6349 | NADH Disodium Salt Hydrate | NADH is a coenzyme that functions as a regenerating electron donor in catabolic processes including glycolysis, β-oxidation and the citric acid cycle. | ||
| E0018 | Triheptanoin | Triheptanoin (API, IND106011, UX007, Glycerol trienanthate) is a synthetic, medium-chain triglyceride consisting of three odd-chain 7-carbon (heptanoate) fatty acids on a glycerol backbone. Triheptanoin is used for treatment of fatty acid oxidation disorders and GLUT1. | ||
| E2035 | Larazotide | Larazotide(AT-1001) is an antagonist of Zonulin, which appears safe and well-tolerated and may offer potential benefit as an adjuvant to immune-targeted therapies. | ||
| E4505 | Deoxyribonucleic acid, single stranded from salmon testes | Deoxyribonucleic acid, single-stranded from salmon testes, is a ready-to-use solution of a high-quality, sonicated, single-stranded template nonspecific DNA blocking agent that reduces background in nucleic acid hybridization. | ||
| S5692 | Mexenone | Mexenone (Benzophenone-10) is a benzophenone-derived sunscreening agent. | ||
| S6055 | (S)-(−)-Limonene | (S)-(−)-Limonene, a fragrance monoterpene mainly found in citrus peel oil, is also naturally occurs in the essential oils of herbs, tea tree oil, and turpentine oil. | ||
| S3497 | Gadobutrol | Gadobutrol (Gadovist, Gadavist,ZK 135079) is a non-ionic macrocyclic gadolinium-based contrast agent (GBCA) that is usedfor tissue contrast enhancement in magnetic resonance imaging (MRI). | ||
| E1703New | SF2312 | SF2312 is a highly potent inhibitor of Enolase with IC50s of 37.9 nM and 42.5 nM for human recombinant ENO1 and ENO2, respectively, and also is a natural phosphonate antibiotic. SF2312 displays activity against bacteria under anaerobic conditions. | ||
| S2008 | Taurine | Taurine is an organic acid widely distributed in animal tissues. | ||
| S4943 | Isovanillin | Isovanillin (5-Formylguaiacol, 3-Hydroxy-p-anisaldehyde, 3-Hydroxy-4-methoxybenzaldehyde) is a reversible inhibitor of aldehyde oxidase. It is largely used as pharmaceutical intermediates and also applied in food and beverage industry, synthetic fragrances, chemical. | ||
| S4995 | Nicotinic acid N-oxide | Nicotinic acid N-oxide (Oxiniacic acid, Nicotinic acid 1-oxide) is nicotinic acid derivative that acts as a ligand and forms lead-carboxylate complexes having phosphorescent properties. | ||
| S9255 | Isoscopoletin | Isoscopoletin (7-Methoxyesculetin) is a member of the class of compounds known as hydroxycoumarins. Isoscopoletin can be found in coriander and eggplant, which makes isoscopoletin a potential biomarker for the consumption of these food products. | ||
| S6057 | 2-Ethylbutyric Acid | 2-Ethylbutyric Acid (2-ethyl hexanoic acid) is a chemical used to make paint dryers and plasticizers. | ||
| E2834 | Hck-IN-1 | Hck-IN-1, a selective Nef-dependent Hck inhibitor, blocks the kinase activity of the Nef:Hck complex in vitro with an IC50 value of 2.8 μM, whereas its activity against Hck alone is >20 μM, also blocks wild-type HIV-1 replication with an IC50 value in the 100-300 nM range. | ||
| E1692 | BAY 2965501 | BAY 2965501 is a potent selective inhibitor of diacylglycerol kinases zeta (DGKζ), restores T-cell cellular DAG level, and induces pERK activation in anergic T-cells via DGK inhibition to assist T-cell mediate tumor cell kill. | ||
| E1827New | ECC5004(AZD5004) | ECC5004(AZD5004, GLP-1 agonist (Eccogene)) is a small molecule GLP-1 receptor agonist (GLP-1RA) used to treat digestive system diseases and endocrine and metabolic diseases. ECC5004 has the potential to be used to treat obesity, type 2 diabetes and metabolic dysfunction-associated steatohepatitis (MASH) disease. | ||
| E5806New | Furimazine | Furimazine (PBI 3939) is a synthetic imidazopyrazinone compound that serves as a substrate for the NanoLuc luciferase (Nluc) enzyme. When combined with Nluc, Furimazine produces exceptionally bright bioluminescent signals in mammalian cells, significantly enhancing the sensitivity of bioluminescence imaging (BLI) applications. | ||
| S4950 | L(+)-Asparagine monohydrate | L-asparagine is a non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue, being used for a variety of pharmaceutical applications. | ||
| S9256 | Isobavachin | Isobavachin is a flavonoid compound obtained from Psoralea Corylifolia Linn. | ||
| S6354 | Ac-Arg-OH | Ac-Arg-OH (N-Acetyl-L-arginine) is one of the guanidino compounds found elevated in the serum of an hemodialyzed renal insufficient (uremic) pediatric population. | ||
| S6607 | YL-109 | YL-109 is a novel antitumor agent that has ability to inhibit breast cancer cell growth and invasiveness in vitro and in vivo. | ||
| E1119 | EG00229 | EG00229 is a neuropilin 1 (NRP1) receptor antagonist with an IC50 of 3 μM against VEGF-A binding to NRP1 b1 domain. | ||
| E1691 | Muvalaplin(LY3473329) | Muvalaplin(LY3473329) is an orally administered small molecule that inhibits lipoprotein (a) (Lp (a)) formation by blocking the apo(a)-apo B100 interaction. It can be used in research of atherosclerotic disease and aortic stenosis. | ||
| S4137 | Eprazinone 2HCl | Eprazinone (NSC 317935) is a mucolytic. | ||
| S4951 | L-Threonine | L-Threonine is an essential amino acid which is in its active form. It is important for the formation of collagen, elastin, and tooth enamel, and aids liver and lipotropic function when combined with aspartic acid and methionine. | ||
| S5218 | Iodixanol | Iodixanol is a nonionic hydrophilic compound commonly used as a contrast agent during coronary angiography. | ||
| S6059 | cis-3-Hexen-1-ol | cis-3-Hexen-1-ol (Leaf alcohol) is a very important aroma compound that is used in fruit and vegetable flavors and in perfumes and acts as an attractant to many predatory insects. | ||
| S6355 | Glycochenodeoxycholic acid sodium salt | Glycochenodeoxycholic acid is a bile salt formed in the liver from chenodeoxycholic acid and glycine, usually found as the sodium salt. It acts as a detergent to solubilize fats for absorption and is itself absorbed. | ||
| S0969 | Heterophyllin B | Heterophyllin B is an active cyclic peptide isolated from Pseudostellaria heterophylla, which provides a novel strategy for the treatment of esophageal cancer. | ||
| E0487 | SP-8356 | SP-8356, an anti-inflammatory synthetic verbenone derivative, is a CD147 inhibitor with respect to its regulation of breast cancer cell behavior and cancer progression. | ||
| E2860 | Collagen | Collagen is a type of collagen, Can be used as a food additive. | ||
| S9911New | Chlorin e6 | Chlorin e6(Ce6, Phytochlorin) is a photosensitizer characterized by strong absorption peaks at 402 nm and 662 nm and intense fluorescence at 668 nm. It possesses antimicrobial and anticancer activities. It activates caspase-3 and induces apoptosis in cells, making it valuable for cancer research.Solutions are unstable and should be fresh-prepared. | ||
| S4138 | Dropropizine | Dropropizine (UCB-1967,(±)- Dropropizine) is a racemic non-opiate antitussive agent, it is used as a cough suppressant. | ||
| S4952 | Fumaric acid | Fumaric acid (Fumarate, 2-Butenedioic acid, Trans-Butenedioic acid) is an intermediate in the citric acid cycle used by cells to produce energy in the form of adenosine triphosphate (ATP) from food; also a product of the urea cycle. | ||
| S6072 | Monomethyl glutarate | Monomethyl glutaric acid (5-Methoxy-5-oxopentanoic acid) is a dicarboxylic acid monoester and has a role as a human urinary metabolite. | ||
| S6356 | 2-Methylsuccinic acid | 2-Methylsuccinic acid (Pyrotartaric acid, 2-methylbutanedioic acid, propane-1,2-dicarboxylic acid, Methylsuccinate) is a normal metabolite found in human fluids. | ||
| S3498 | Ecamsule.2Na | Ecamsule.2Na is the Sodium salt form of Ecamsule. Ecamsule is an active ingredient of sunscreens that protects the skin from sunburn and erythema. | ||
| E2862 | (+/-)-Naringenin | (±)-Naringenin, a natural flavonoid present in citrus fruits, induces apoptosis and cytotoxicity in cancer cells. | ||
| S5139 | Methyl Dihydrojasmonate | Methyl dihydrojasmonate (Hedione, Kharismal) is a flavouring ingredien with the smell vaguely similar to jasmin. | ||
| S5251 | Ritalinic acid | Ritalinic acid (α-phenylpiperidine-2-acetic acid) is a substituted phenethylamine and an inactive major metabolite of the psychostimulant drugs methylphenidate. Ritalinic acid can be biodegraded and used as a sole carbon and nitrogen source by various microbial strains originating from different environmental samples. | ||
| S5675 | Yamogenin | Yamogenin, a sapogenin found in fenugreek, inhibits lipid accumulation through the suppression of gene expression in fatty acid synthesis in hepatocytes. | ||
| S6079 | 2-Methylhexanoic acid | 2-Methylhexanoic acid is a flavouring ingredient. | ||
| S6357 | 1,5-Diaminopentane dihydrochloride | 1,5-Diaminopentane (Cadaverine) is a foul-smelling diamine formed by bacterial decarboxylation of lysine that occurs during protein hydrolysis during putrefaction of animal tissue. | ||
| E2863 | Garcinia cambogia extract | Garcinia cambogia extract has hypocholesterolemic effect and used for obesity treatment. (-)-hydroxycitrate (HCA), the chief compound of standardized Garcinia cambogia extract, is a competitive inhibitor of ATP-citrate-lyase. | ||
| S9450 | 1-Undecanol | 1-Undecanol (Undecyl alcohol, 1-Hendecanol), found naturally in many foods such as fruits (including apples and bananas), butter, eggs and cooked pork, is used as a flavoring ingredient. | ||
| S9265 | 7-Epitaxol | 7-Epitaxol (7-Epipaclitaxel) is the major derivative of taxol found in cells. Taxol (paclitaxel) is a well-known natural-source cancer drug. | ||
| S5945 | Alverine | Alverine is a smooth muscle relaxant. | ||
| S3505 | Polidocanol | Polidocanol (Polyoxyethylene lauryl ether, Polyoxyethyleneglycol Dodecyl Ether, Brij30, Laureth-23, Varithena) is a sclerosant used for treating uncomplicated spider veins and reticular veins in the lower extremities. | ||
| S4960 | Jasmone | Jasmone is a natural organic compound extracted from the volatile portion of the oil from jasmine flowers. | ||
| S5730 | Alimemazine Tartrate | Alimemazine (Trimeprazine Tartrate, Methylpromazine Tartrate) is a phenothiazine derivative that is used as an antipruritic. | ||
| S6089 | 3-Methylvaleric acid | 3-Methylvaleric acid is a flavouring ingredient. | ||
| E2251 | Mutated EGFR-IN-1 | Mutated EGFR-IN-1 (Osimertinib analog) is a useful intermediate for the inhibitors design for mutated EGFR, such as L858R EGFR, Exonl9 deletion activating mutant and T790M resistance mutant. | ||
| E4634New | MIRA-1 | MIRA-1(NSC 19630), a maleimide compound, is a selective inhibitor of Werner syndrome WRN helicase activity with an IC50 of 20 µM while sparing ATPase and exonuclease activities. It reactivates mutant p53, inducing apoptosis in various human solid tumor cell lines with tetracycline-regulated mutant p53. | ||
| E1533New | Lipofermata | Lipofermata is an inhibitor of fatty acid transport protein 2 (FATP2) that demonstrates fatty acid transport inhibition with an IC50 of 4.84 μM in Caco-2 cells. It may offer therapeutic potential for diseases where lipotoxicity is a key factor. | ||
| S3965 | Vanillyl Butyl Ether | Vanillyl Butyl Ether (4-(Butoxymethyl)-2-methoxyphenol), an ether of monohydroxybenzoic acid, is added to food products as a flavoring agent. It is also present in cosmetics and personal care products as a fragrance ingredient, oral care agent, hair conditioning agent, and warming or cooling agent. | ||
| S5672 | Hydroxyhexamide | Hydroxyhexamide is a pharmacologically active metabolite of acetohexamide, which is a sulfonylurea hypoglycemic agent. | ||
| S9267 | Epimedin A | CHF5074 is a gamma-secretase modulator that reduces Aβ42 and Aβ40 secretion. The IC50s of CHF5074 for inhibition of COX-1 and COX-2 is above 100 μmol/L. | ||
| S5801 | Ala-Gln | Ala-Gln (l-alanyl-l-glutamine), a dipeptide composed of alanine and Gln, is an alternative supplement to L-glutamine in the production of biopharmaceuticals with better solubility and stability than glutamine (Gln). | ||
| S6099 | 2-Methylheptanoic Acid | 2-Methylheptanoic Acid is a flavouring ingredient. | ||
| E4026 | Poly(2-hydroxyethyl methacrylate) | Poly(2-hydroxyethyl methacrylate) is one of the most important hydrogels in the world of biomaterials. It is the basic component of contact lenses and is also used in the implantation of soft tissues, synthetic transplant for gristle and bone, regeneration of neurotic tissue, transmission of agents, etc. | ||
| E1403New | Fumarate hydratase-IN-1 | Fumarate hydratase-IN-1 is a small molecule cell-permeable inhibitor of fumarate hydratase. It induce alteration of TCA cycle metabolites, modulation of cytosolic processes, and substantial redox stress responses. | ||
| E4759New | MS41 | MS41 is a highly potent and selective PROTAC degrader of eleven-nineteen leukemia (ENL) that recruits the von Hippel–Lindau (VHL) E3 ubiquitin ligase, with DC50 values of 3.50 nM (MV4;11), 2.84 nM (SEMK2), 3.03 nM (Jurkat), and 26.58 nM (KASUMI1). It suppresses oncogenic gene expression, inhibits leukemia cell proliferation, and reduces MLL-r leukemia progression in a xenograft mouse model. | ||
| S9371 | 1-Iodoadamantane | 1-Iodoadamantane (Adamantyl iodide) is a chemical | ||
| S9268 | Epmedin B | Epmedin B (Epimedin B) is a component extracted from Epimedii Folium and may have antiosteoporotic activity. | ||
| P1242New | Proteinase K | Proteinase K is a serine endoprotease, is used for isolating amyloid cores and is effective over a wide pH range (4–12), including in the presence of SDS or urea. It is commonly used as a preparative reagent for destruction of proteins, including DNAses and RNAses, in DNA and RNA preparations. | ||
| S2424 | Hypoxanthine | Hypoxanthine, a naturally occurring purine derivative, an intermediate product of uric acid synthesis, formed from adenylic acid and itself a precursor of xanthine. | ||
| S9449 | Urocanic acid | Urocanic acid is an intermediate in the catabolism of L-histidine. | ||
| S9269 | Epmedin C | Epmedin C (Epimedin C, Baohuoside VI), a flavonoid isolated from the herbs of Epimedium brevicornum Maxim, exhibits immunostimulatory and anticancer activities. | ||
| S6107 | 1-Furfurylpyrrole | 1-Furfurylpyrrole (N-Furfurylpyrrole) is a potential contributor of flavor and aroma to popcorn. | ||
| E0006 | Gadoteridol | Gadoteridol (ProHance, SQ-32692, Gd-HP-DO3A) is a nonionic contrast agent for magnetic resonance imaging (MRI). | ||
| S5680 | (-)-Verbenone | (-)-Verbenone (2-Pinen-4-one), an important component of the essential oil from rosemary, is an insect pheromone with a spicy odor and camphoraceous fragrance. | ||
| S5758 | 2-Methoxycinnamic acid | 2-Methoxycinnamic acid (AI3-11206) is a cinnamic acid with magnetic properties. | ||
| S9270 | Dracohodin perochlorate | CHF5074 is a gamma-secretase modulator that reduces Aβ42 and Aβ40 secretion. The IC50s of CHF5074 for inhibition of COX-1 and COX-2 is above 100 μmol/L. | ||
| E0842 | Benzenepentanol | Benzenepentanol undergoes oxidation in the presence of ceric ammonium nitrate to yield 2-benzyltetrahydrofuran. | ||
| E1263 | Lac-Phe | N-Lactoyl-Phenylalanine (Lac-Phe) is a blood-borne signalling metabolite induced upon exercise. | ||
| E4587 | Sodium alginate | Sodium alginate is a sodium salt of alginic acid, can be extracted and purified from the cell walls brown seaweed Laminaria japonica. It has chelating activity and can be used to adsorb heavy metal ions, also has mucosal-protective and hemostatic effects and used in food additives and pharmaceuticals. | ||
| S9501 | Pedunculoside | Pedunculoside is a novel triterpene saponin extracted from the dried barks of Ilex rotunda Thunb, showing lipid-lowering effects. | ||
| S9357 | Phenylacetaldehyde | Phenylacetaldehyde (Hyacinthin, Phenylethanal) is an organic compound used in the synthesis of fragrances and polymers. | ||
| S5761 | Citric acid | Citric acid is a weak organic acid that occurs naturally in citrus fruits. It is an intermediate in the citric acid cycle. | ||
| E0024 | 4-Vinylcyclohexene dioxide | 4-Vinylcyclohexene dioxide (Vinylcyclohexene dioxide, VCD) is a chemical used to induce menopause and decrease estrogen production. 4-Vinylcyclohexene dioxide is used as a crosslinking agent for the production of epoxy resins. | ||
| E2864 | Cy7 | Cy7 (Sulfo-Cyanine7) is a fluorescence labelling agent, used to label proteins, antibodies, peptides, and oligonucleotides. | ||
| E4636New | W-7 hydrochloride | W-7 hydrochloride is a potent antagonist of calmodulin (CaM) that inhibits Dengue virus (DENV) translation and replication. It also competitively inhibits Trypsin-treated Ca2+/calmodulin-dependent phosphodiesterase (Ca2+-PDE). It exhibits anti-proliferative and anti-tumor effect. | ||
| S5126 | Aleuritic Acid | Aleuritic Acid (Aleuritolic acid, 9,10,16-trihydroxy-palmitic acid), a major constituent acid of lac resin (shellac), is isolated from the resin and mainly used in the perfumery industry as a starting material for the preparation of "musk" aroma compounds as well as medicinal and bioactive compounds. | ||
| S6402 | 2-Aminoethanethiol | 2-Aminoethanethiol (cysteamine, β-Mercaptoethylamine, 2-Mercaptoethylamine, Thioethanolamine, Mercaptamine) is a radiation-protective agent that oxidizes in air to form cystamine. | ||
| E1216 | Heclin | Heclin is an inhibitor of HECT-type E3 ubiquitin ligase with an IC50 of 6.8, 6.3, and 6.9 μM for Smurf2, Nedd4, and WWP1 HECT domains, respectively. | ||
| E4728New | VVD-130037(BAY-3605349) | VVD-130037(BAY-3605349) is an orally available covalent small molecule activator of Kelch-like ECH associated protein 1 (KEAP1), which provide enhanced cellular degradation of nuclear factor-erythroid 2 p45-related factor 2 (NRF2) resulting in significant inhibition of tumor growth in advanced solid tumors. | ||
| S4600 | Benzyl alcohol | Benzyl alcohol (Phenylmethanol, Benzenemethanol, Phenylcarbinol, Benzoyl alcohol) is used as a local anesthetic. Also, it is used in the manufacture of other benzyl compounds, as a pharmaceutic aid, and in perfumery and flavoring. | ||
| S5127 | Spiculisporic Acid | Spiculisporic acid (4,5-dicarboxy-4-pentadecanolide) is a bioactive γ-butenolide isolated from a marine Aspergillus. | ||
| S9273 | Timosaponin BII | Timosaponin BII (BII, Prototimosaponin AIII) is a steroidal saponin showing potential anti-dementia and antioxidant activity. | ||
| S6124 | 3-Hydroxyisovaleric acid | 3-Hydroxyisovaleric acid is a normal human metabolite excreted in the urine. | ||
| S6668 | NVS-ZP7-4 | NVS-ZP7-4,a Zinc transporter SLC39A7 (ZIP7) inhibitor,is the first reported chemical tool to probe the impact of modulating ER zinc levels and investigate ZIP7 as a novel druggable node in the Notch pathway. | ||
| E7278New | L-Methionine-DL-sulfoximine | L-Methionine-DL-sulfoximine (MSX, MSO) is an irreversible inhibitor of glutamine synthetase (GS) and pre-treatment delays the onset of behavioral and electrographic seizures in Pilo-treated rats. It also acts as a potent convulsant that metabolically and morphologogically primarily affects astroglia. | ||
| S3071 | Vanillin | Vanillin (FEMA 3107), 4-hydroxy-3-methoxybenzaldehyde is a food additive. | ||
| S5134 | D(-)-Arabinose | D-Arabinose is a reducing sugar useful as a substrate in analysis of arabinose isomerases and synthesis of D-erythroascorbic acid in yeast. | ||
| S4886 | Menbutone | Menbutone (Genabilin, Naftobil, Genabilic acid), or genabilic acid, is a derivative of oxybutyric acid which acts as a choleretic stimulating secretion, a trypsinogen and a pepsinogen. | ||
| S5391 | α-Boswellic acid | α-Boswellic acid is a naturally occuring triterpenoic acid. | ||
| S5682 | Methyl linolenate | Methyl linolenate (Linolenic acid methyl ester, Methyl alpha-linolenate) is a fatty acid methyl ester derived from alpha-linolenic acid and acts as a plant metabolite and an insect attractant. | ||
| S9274 | Isochlorogenic acid B | Isochlorogenic acid B, naturally isolated from Laggera alata, has antioxidative and hepatoprotective properties. | ||
| S6125 | Glycerol trilinoleate | Glycerol trilinoleate (Trilinolein) is a triacylglycerol and has been reported to provide a number of beneficial effects including reducing thrombogenicity and arrhythmias and increasing erythrocyte deformability. It is also an antioxidant. | ||
| S6826 | IPTG | IPTG (Isopropyl β-D-thiogalactoside, Isopropyl thiogalactoside, Isopropyl β-D-1-thiogalactopyranoside, lad-y) is a galactose and a molecular mimic of allolactose that triggers transcription of the lac operon, stimulating protein expression. | ||
| E2867 | perflexane | Perflexane (Perfluorohexane) is a fluoroalkane that function as a radioopaque medium and a non-polar solvent. It is used as a contrast agent for ultrasound imaging. | ||
| S2260 | Amygdalin | Amygdalin is a glycoside initially isolated from the seeds of the tree Prunus dulcis, also known as bitter almonds. | ||
| S5135 | Hydroferulic acid | Hydroferulic acid (Dihydroferulic acid, Dihydroconiferylic acid) is classified as a member of the phenylpropanoic acids. It is slightly soluble in water and acidic. | ||
| S5349 | Ethyl chrysanthemumate | Ethyl chrysanthemate (Chrysanthemic acid ethyl ester) is an allelochemical compound used as an attractant. | ||
| S5392 | Mepivacaine | Mepivacaine (Carbocaine) is a local anesthetic indicated for infiltration, nerve block, and epidural anesthesia. | ||
| S6358 | Indole | Indole (2,3-Benzopyrrole) is an aromatic heterocyclic organic compound widely distributed in the natural environment and can be produced by a variety of bacteria. | ||
| S6788 | PEO-IAA | PEO-IAA (2-(1H-Indol-3-yl)-4-oxo-4-phenyl-butyric acid) is a novel potent auxin antagonist that binds to transport inhibitor response 1/auxin signaling F-box proteins (TIR1/AFBs). PEO-IAA suppresses not only the expression of an auxin-responsive ZmSAUR2 gene, but also gravitropic curvature. | ||
| S6093 | H-Phe-Phe-OH | H-Phe-Phe-OH (Phenylalanyl-phenylalanine, Phe-Phe, L-Phe-L-Phe) is a short peptide diphenylalanine with utility for potential applications in biomaterial chemistry, sensors and bioelectronics. | ||
| S3125 | N-Formylglycine | N-Formylglycine (2-formamidoacetic acid, For-Gly-OH, FGly) is an endogenous metabolite. |
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| E0019 | Dipivefrin Hydrochloride | Dipivefrin (Dipivefrine, Propine, Pivalephrine) is a prodrug of epinephrine which is hydrolyzed to epinephrine after absorption into the eye. | ||
| S5528 | Acetophenone | Acetophenone (Methyl phenyl ketone, Phenylethanone) is an organic compound used as fragrances and a raw material for the synthesis of some pharmaceuticals. | ||
| S6148 | 3-Methyl-2-oxobutanoic acid | 3-Methyl-2-oxobutanoic acid (alpha-Ketoisovalerate, alpha-Ketoisovaleric acid), a neurotoxin, an acidogen and a metabotoxin, is an abnormal metabolite that arises from the incomplete breakdown of branched-chain amino acids. | ||
| S3126 | Sodium 2-hydroxybutanoate | Sodium 2-hydroxybutanoate (Sodium 2-hydroxybutyrate, Sodium DL-2-hydroxybutyrate), converted from 2-Aminobutyric acid, is an intermediate metabolite. |
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| E1904New | SKF-34288 hydrochloride | SKF-34288 hydrochloride(3-Mercaptopicolinic acid hydrochloride, 3-MPA hydrochloride) is an orally active, specific inhibitor of phosphoenolpyruvate carboxykinase (PEPCK) with Ki values of 2-9 μM. SKF-34288 hydrochloride is a potent hypoglycemic agent by inhibiting glucose synthesis. SKF-34288 hydrochloride also inhibits cell proliferation, induces myogenic differentiation in vitro. | ||
| S5334 | Tigogenin | Tigogenin is one of steroidal sapogenins which is widely used for synthesizing steroid drugs. It might have protective effect on bone and be helpful in preventing the development of osteoporosis. | ||
| S5759 | Methyl linoleate | Methyl linoleate (Linoleic acid methyl ester), found in cloves, is a fatty acid methyl ester of linoleic acid which is an essential fatty acid in mammalian nutrition and is used in the biosynthesis of prostaglandins and cell membranes. | ||
| S9277 | Alisol A | Alisol A is one of the major active triterpenes isolated from Rhizoma Alismatis (RA), a famous Traditional Chinese Medicine widely used for diuretic, hypolipidemic, anti-nephrolithic, anti-atherosclerotic, anti-inflammatory and anti-diabetic purposes. | ||
| S6360 | 2-Hydroxypyridine | 2-Hydroxypyridine (2-Pyridino, 2-Pyridone) is used in peptide synthesis. | ||
| S0984 | KCC-07 | KCC-07 is a potent, selective and brain-penetrant inhibitor of MBD2 (methyl-CpG-binding domain protein 2) with anticancer activity. It prevents binding of MBD2 to methylated DNA and activates brain specific angiogenesis inhibitor 1 (BAI1) inducing anti-proliferative BAI1/p53/p21 signaling. | ||
| S3127 | 2,4-Dihydroxypyrimidine-5-carboxylic acid | 2,4-Dihydroxypyrimidine-5-carboxylic Acid (Uracil 5-carboxylic acid, Isoorotic acid, 5-Carboxyuracil) is an endogenous metabolite. |
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| E4265 | Pyrimidine | Pyrimidine is an endogenous metabolite. It is used to study the photoinduced ion chemistry of the halogenated pyrimidines, a class of prototype radiosensitizing molecules, and is also used to assess pyrimidine/purine asymmetry quantitatively. | ||
| S4153 | D-Phenylalanine | D-Phenylalanine, a carboxypeptidase A, endorphinase and enkephalinase inhibitor, enhances endorphin production and diminishes pain. | ||
| S3843 | Madecassoside | Madecassoside (Asiaticoside A) is the main active triterpene constituent of Centella asiatica herbs, a traditional Chinese medicine for wound healing and scar management. | ||
| S4828 | Sodium carbonate | Sodium Carbonate (Disodium carbonate, Soda Ash, Carbonic acid disodium salt) is the disodium salt of carbonic acid with alkalinizing property. | ||
| S5335 | Corey Lactone Diol | Corey Lactone Diol is a pharmaceutical intermediate. | ||
| S5762 | Methyl Oleate | Methyl Oleate (oleic acid methyl ester, Methyl cis-9-Octadecenoate) is a methyl ester of oleic acid, which is a monounsaturated fatty acid and is one of the major components of membrane phospholipids. | ||
| S6150 | Farnesyl Acetate (mixture of isomers) | Farnesyl Acetate is a flavouring compound identified in foods such as blueberries. | ||
| S6361 | 3-Amino-4-hydroxybenzoic acid | 3-Amino-4-hydroxybenzoic acid is a monohydroxybenzoic acid. | ||
| S3253 | Xylobiose | Xylobiose (1,4-β-D-Xylobiose, 1,4-D-Xylobiose), a disaccharide of xylose monomers, is a natural substrate that can be hydrolysed by Beta-D-Xylosidase/alpha-L-arabinofuranosidase from Selenomonas ruminantium (SXA). | ||
| S3128 | N-Acetyl-D-galactosamine | N-Acetyl-D-galactosamine (D-N-Acetylgalactosamine) is an endogenous metabolite. |
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| S9197 | Maltohexaose | Maltohexaose (Amylohexaose) is a polysaccharide with 6 units of glucose and can be classified as a maltodextrin. | ||
| E1148 | BOS-318 | BOS-318 is a potent, slowly dissociating, highly selective, and cell-permeable furin inhibitor with IC50 value of 1.9 nM. | ||
| E2872 | Clocortolone Pivalate | Clocortolone pivalate is a mid-potent topical corticosteroid available as a 0.1% emollient cream used in the treatment of corticosteroid-responsive dermatoses. | ||
| S3952 | 3,4-Dihydroxybenzaldehyde | 3,4-Dihydroxybenzaldehyde (Protocatechuic aldehyde) is a phenolic aldehyde, a precursor in vanillin synthesis via biotransformation by cell cultures of Capsicum frutescens, a type of chili pepper. | ||
| S4936 | Antiarol | Antiarol (3,4,5-trimethoxyphenol) is a member of aromatic phenols and exhibits moderate DPPH free radical scavenging activity. | ||
| S5396 | 4'-Hydroxypropiophenone | 4'-Hydroxypropiophenone (Paroxypropione, p-hydroxypropiophenone) is a member of acetophenones. | ||
| S6362 | N-Acetyl-L-phenylalanine | N-Acetyl-L-phenylalanine is a hazardous amphipathic metabolite of phenylalanine. | ||
| S3252 | Xylotriose | Xylotriose (1,4-b-D-Xylotriose, 1,4-beta-D-xylotriose) is a natural xylooligosaccharide substrate that can be hydrolysed by catalytically efficient beta-D-xylosidase from Selenomonas ruminantium (SXA). | ||
| E0791 | PTGR2-IN-1 | PTGR2-IN-1 is a potent prostaglandin reductase 2 (PTGR2) inhibitor with an IC50 of ~0.7 μM. | ||
| E2869 | Propiolactone | Propiolactone(β-Propiolactone), a sterilizing and sporicidal agent, is used to sterilize blood plasma, vaccines, tissue grafts, surgical instruments and enzymes. | ||
| S3958 | 3,5-Diiodotyrosine Dihydrate | 3,5-Diiodotyrosine Dihydrate (Iodogorgoic acid, apothyrin, jodgorgon) is a product from the iodination of monoiodotyrosine. In the biosynthesis of thyroid hormones, diiodotyrosine residues are coupled with other monoiodotyrosine or diiodotyrosine residues to form T4 or T3 thyroid hormones. | ||
| S5338 | L(-)-Sorbose | L(-)-Sorbose (L(-)-Sorbopyranose) is a ketose sugar that is commonly used in the commercial synthesis of ascorbic acid. | ||
| S5756 | Methyl Stearate | Methyl Stearate (Methyl Octadecanoate, Stearic Acid methyl ester), found in cloves, is an antifoaming agent and fermentation nutrient. | ||
| S6162 | 2-Octenoic acid | 2-Octenoic acid (2-Octenoate) is a normal organic acid produced by hepatic microsomal oxidation of aliphatic aldehydes and is a metabolite naturally found in the urine and plasma. | ||
| S6363 | 3-Hydroxybenzyl alcohol | 3-Hydroxybenzyl alcohol is used as an intermediate to produce other chemicals. | ||
| S7821 | Bufalin | Bufalin (BF) is a potent inhibitor of steroid receptor coactivator SRC-3, SRC-1 and Na+/K+-ATPase. Bufalin binds to the subunit α1, α2 and α3 of Na+/K+-ATPase with Kd of 42.5 nM, 45 nM and 40 nM, respectively. Bufalin is a major digoxin-like immunoreactive component isolated from the Chinese medicine Chan Su with anti-cancer activity. | ||
| S3134 | D-(-)-Tartaric acid | D-(-)-Tartaric acid is the unnatural isomer of Tartaric acid which is an important chiral chemical building block with broad industrial and scientific applications. |
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| E4854New | Sodium picosulfate monohydrate | Sodium picosulfate monohydrate, is a polyphenolic stimulant laxative and prodrug form of desacetyl bisacodyl (DAB). It is used for treating idiopathic constipation and preparing the bowel before colonoscopy. | ||
| S5970New | Selenomethionine | Selenomethionine (Seleno-DL-methionine, DL-Selenomethionine) is a naturally occurring amino acid containing selenium. Selenomethionine (SeMet) can substitute for methionine (Met) during protein synthesis in a non-specific manner. Due to the significant differences in their redox properties, the incorporation of SeMet in place of Met may adversely impact protein function. | ||
| S4939 | cis-Aconitic acid | Cis-Aconitic acid (cis-aconitate, Achilleic acid, Citridinic acid, Equisetic acid, Pyrocitric acid) is an intermediate in the tricarboxylic acid cycle produced by the dehydration of citric acid. | ||
| S0082 | PH-002 | PH-002, an inhibitor of intracellular domain interaction of apolipoprotein E4 (ApoE4) in nerve cells. | ||
| E0792 | SW-106065 | SW-106065 is an apoptosis inducer in malignant peripheral nerve sheath tumors (MPNST), which can inhibit ATP consumption of sporadic MPNST and other models of MPNST with an EC50 of 1 µM. | ||
| S2883 | 4-Aminohippuric Acid | 4-Aminohippuric acid is a typical substrate of organic anion transport systems. | ||
| S8540 | Voxelotor | Voxelotor is a novel small molecule hemoglobin modifier which increases hemoglobin oxygen affinity. | ||
| S3844 | Rosavin | Rosavin, a cinnamyl alcohol glycoside found in the plant Rhodiola rosea, possesses antidepressant and anxiolytic activities. | ||
| S4841 | Laurocapram | Laurocapram (N-Dodecylcaprolactam, Azone, N-0252, N-Lauryl caprolactam, Tranzone) is a skin penetration enhancer that facilitates absorption of cutaneously applied substances. | ||
| S5561 | Ethacrynic Acid | Ethacrynic Acid is a loop or high ceiling diuretic used for the treatment of high blood pressure and edema caused by diseases like congestive heart failure, liver failure, and kidney failure. | ||
| S6167 | 2-Methyl-4-pentenoic Acid | 2-Methyl-4-pentenoic acid is a branched-chain fatty acid. | ||
| S6366 | Quinaldic acid | Quinaldic acid is a product of l-tryptophan catabolism, via kynurenic acid, found in human urine. | ||
| S9919 | Pimonidazole | Pimonidazole (Ro 03-8799) is a novel hypoxia marker used for complementary study of tumor hypoxia and cell proliferation in cervical carcinoma. | ||
| E2870 | dimyristoyl lecithin | dimyristoyl lecithin (DMPC) is a synthetic phospholipid used in liposomes. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine is used for the study of lipid monolayers and bilayers. | ||
| E1272New | SRI-37330 HCl | SRI-37330 HCl(EX-A5854), an anti-diabetic drug, is an orally bioavailable inhibitor of thioredoxin-interacting protein (TXNIP), with an IC50 of 0.64 μM for TXNIP expression in INS-1 cells. Its treatment inhibits glucagon secretion and function, decreases hepatic glucose production, and reverses hepatic steatosis. | ||
| S2884 | Acesulfame Potassium | Acesulfame potassium is a non-nutritive sweetener. | ||
| S9282 | Isochlorogenic acid A | Isochlorogenic acid A (3,5-dicaffeoylquinic acid), isolated from Brazilian propolis and Suaeda glauca, exhibits hepatoprotective and cytotoxic activities. | ||
| S9456 | Mangafodipir Trisodium | Mangafodipir trisodium (MnDPDP), hepatocellular-specific contrast agent, is an efficacious inhibitor of CIPN (chemotherapy-induced peripheral neuropath) and other conditions caused by cellular oxidative stress. Mangafodipir trisodium shows no negative interference with the tumoricidal activity of chemotherapy. | ||
| S3145 | Pimelic acid | Pimelic acid (Heptanedioic acid, 1,5-Pentanedicarboxylic acid, 1,7-Heptanedioic acid) originating from fatty acid synthesis pathway is a bona fide precursor of biotin in B. subtilis. |
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| E1204 | NVP-DKY709 | NVP-DKY709 is a potent IKZF2 inhibitor for the treatment of cancers. | ||
| E1758New | Bersacapavir | Bersacapavir(JNJ-6379, JNJ-56136379) is a potent capsid assembly modulator (CAM) that accelerates capsid assembly and induces the formation of morphologically intact viral capsids devoid of genomic material. It inhibits HBV replication with an EC50 of 54 nM in HepG2.117 cells. | ||
| A2169New | Anti-mouse MHC Class II (I-A/I-E)-InVivo | |||
| S7594 | Abscisic Acid (Dormin) | Abscisic Acid (Dormin, Abscisin II) is a plant hormone, which is involved in many plant developmental processes, modulates ion homeostasis and metabolism, and inhibits germination and seedling growth. | ||
| S4652 | Sulisobenzone | Sulisobenzone (Benzophenone-4, Sungard) is an ingredient in some sunscreens which protects the skin from damage. | ||
| S9283 | Aristolone | Aristolone, which could be extracted from essential oil of Elyonurus hensii, is likely to induce an antalgic activity. | ||
| S3152 | Glutaric acid | Glutaric acid (GA) is an attractive C5 dicarboxylic acid with wide applications in the biochemical industry. |
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| E2866 | Sodium tetradecyl sulfate | Sodium tetradecyl sulfate, a detergent sclerosant, is widely used agent for esophageal varices and varicose veins. | ||
| E1913New | MZ-101 | MZ-101 (GYS1-IN-2) is a potent small molecule inhibitor of Glycogen synthase 1(GYS1) with an IC50 value of 0.041 µM. By depleting muscle glycogen, MZ-101 treatment normalizes glycogen levels and corrects transcriptional and metabolic abnormalities in Pompe mice. | ||
| A2170New | Anti-mouse CSF1-InVivo | |||
| S4653 | L-Ornithine hydrochloride | L-ornithine hydrochloride ((S)-2,5-Diaminopentanoic acid) has an antifatigue effect by increasing the efficiency of energy consumption and promoting the excretion of ammonia. It is one of the key reactants in the urea cycle. | ||
| S3847 | Panaxatriol | Panaxatriol is a triterpene sapogenin originally found in species of Panax (ginseng) and exhibits anti-inflammatory, hepatoprotective, anti-arrhythmic, and antioxidative activities. | ||
| S6187 | N-(5-Aminopentyl)acetamide | N-(5-Aminopentyl)acetamide (Monoacetylcadaverine, N-Acetylcadaverine) is the acetylated form of the polyamine cadaverine, which is a foul-smelling diamine compound. | ||
| S3159 | Citraconic acid | Citraconic acid (CA) is a kind of methyl-branched fatty acids that exists in wild soybean. |
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| E0027 | 5-Hydroxymethylcytosine | 5-Hydroxymethylcytosine (5hmC) is a naturally existing component in mammalian genomic DNA and is regarded as the sixth DNA base. 5-Hydroxymethylcytosine is an intermediate metabolite in active DNA demethylation. 5-Hydroxymethylcytosine is epigenetic marks known to affect global gene expression in mammals. | ||
| E1333 | wiskostatin | Wiskostatin is a potent and selective inhibitor of neuronal Wiskott-Aldrich syndrome protein (N-WASP)-mediated actin polymerization. Wiskostatin causes a rapid, profound, and irreversible decrease in cellular ATP levels. | ||
| S4161 | Benzoic Acid | Benzoic acid (FEMA 2131) is a colorless crystalline solid and a simple aromatic carboxylic acid, used as a food preservative. | ||
| S4742 | Rebaudioside C | Rebaudioside C (Dulcoside B) belongs to the family of Steviol Glycosides. It is a natural constituent of the plant Stevia rebaudiana Bertoni and used as natural sweeteners to diabetics and others on carbohydrate-controlled diets. | ||
| S3848 | Hydroxytyrosol Acetate | Hydroxytyrosol acetate (HTy-Ac), an extra virgin olive oil (EVOO) polyphenol, exhibits antioxidant and anti-inflammatory effects. | ||
| S5303 | Afalanine (N-Acetyl-DL-phenylalanine) | Afalanine (N-Acetyl-DL-phenylalanine, Afalanine) acts as an antidepressant and a metabolite. | ||
| S6016 | D-Proline | D-proline is an isomer of the naturally occurring amino acid, L-Proline. | ||
| S9460 | Ethotoin | Ethotoin (Peganone) is a hydantoin derivative and an orally active anticonvulsant agent. It also exerts an antiepileptic effect and can be used in epilepsy research. | ||
| S6021 | 5-Methylcytosine | 5-Methylcytosine, a methylated form of the DNA base cytosine, is a major epigenetic mark in the nuclear DNA in mammals and may be involved in the regulation of gene transcription. | ||
| S6615 | ATB 346 | ATB 346, a novel hydrogen sulphide-releasing derivative of naproxen with remarkably reduced toxicity, inhibits COX activity. ATB 346 is an anti-inflammatory agent that induces apoptosis of human melanoma cells. | ||
| S3330 | Maleamic acid | Maleamic acid ((Z)-4-Amino-4-oxobut-2-enoic acid) is an endogenous metabolite. |
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| E4275New | β-Aminopropionitrile | β-Aminopropionitrile (BAPN) is an orally active, specific, and irreversible inhibitor of lysyl oxidase (LOX). It targets the active site of LOX or LOXL isoenzymes. | ||
| E4734New | MeAIB | MeAIB (α-(Methylamino)isobutyric acid) is a specific substrate for amino acid transport system A, especially System A (ATA1). It also inhibits SNAT2, which reduces intracellular levels of essential amino acids and impairs cell proliferation in porcine enterocytes by disrupting the mTOR signalling pathway. | ||
| S3955 | Uric Acid | Uric Acid, a normal component of urine, is a product of the metabolic breakdown of purine nucleotides. | ||
| S5702 | Fenipentol | Fenipentol (1-phenylpentan-1-ol, 1-Phenyl-1-pentanol, 1-Phenylpentanol) is a member of benzenes and stimulates plasma secretion & exocrine pancreatic secretion. | ||
| S5743 | γ-Linolenic acid | γ-Linolenic Acid (18:3, n-6), the Δ6-desaturase product of linolenic acid, is an unsaturated fatty acid found primarily in vegetable oils. | ||
| S6054 | Glycyl-L-leucine | Glycyl-l-leucine is a dipeptide that appears to be a common substrate for glycyl-leucine dipeptidase. | ||
| S3339 | 3-(2-Hydroxyphenyl)propionic acid | 3-(2-Hydroxyphenyl)propanoic acid (Melilotic acid, Melilotate, 2-hydroxybenzenepropanoic acid) is an endogenous metabolite. |
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| S4819 | Saccharin | Saccharin (Benzoic sulfimide, O-Sulfobenzimide, O-Benzoic sulfimide, Saccharimide) is an artificial sweetener with effectively no food energy. | ||
| S5477 | Gefarnate | Gefarnate (Geranyl farnesylacetate) is a synthetic compound used for the treatment of gastric ulcers. | ||
| S6204 | Allyl Methyl Sulfide | Allyl Methyl Sulfide (3-Methylthio-1-propene), a bioactive organosulfur compound found in garlic, is reported to modulate disease states such as cancer and infection. | ||
| S6056 | N-Methylsarcosine | N-Methylsarcosine (N,N-Dimethylglycine, (Dimethylamino)acetic acid) is a natural N-methylated glycine that is used in the development of glycine-based ionic liquids and emulsifiers. | ||
| E0478 | Procyanidin C1 | Procyanidin C1 is a polyphenolic component of grape seed extract, increases the healthspan and lifespan of mice through its action on senescent cells. PCC1 is a natural senotherapeutic agent with in vivo activity and a potential intervention to delay, alleviate or prevent age-related pathologies. | ||
| E2881 | Cefotetan disodium salt | Cefotetan disodium salt is a semisynthetic cephamycin antibiotic that exerts its bactericidal effects by inhibition of cell-wall synthesis. It showed in vitro efficacy against ESBL-producing E.coli bloodstream isolates with MIC50 of 0.25 mg/L. | ||
| E4852New | Tafamidis meglumine | Tafamidis meglumine (Vyndaqel, Fx-1006A) stabilizes the tetrameric structure of transthyretin (TTR) by binding to thyroxine-binding sites. Tafamidis meglumine treats transthyretin familial amyloid polyneuropathies (TTR-FAP), a condition characterized by neurological damage from TTR amyloidosis, by preventing the misfolding and aggregation of transthyretin (TTR) into amyloid fibrils. | ||
| E4922New | Allopurinol riboside | Allopurinol riboside, a metabolite of allopurinol, competitively inhibits the action of purine nucleoside phosphorylase on inosine in vitro with a Ki value of 277 μM. It displays potent activities against parasites. | ||
| E1616New | AZD8797( KAND567) | AZD8797 (KAND567) is an allosteric, non-competitive, and orally active antagonist of the human receptor CX3CR1. It antagonizes CX3CR1 with a Ki value of 3.9 nM, respectively. It effects G-protein signaling and β-arrestin recruitment. | ||
| S4047 | Bisacodyl | Bisacodyl (INN) is a stimulant laxative drug that works directly on the colon to produce a bowel movement. | ||
| S4894 | D-Glucurone | D-Glucurone is a glucuronic acid derivative that is used for treating canine hepatitis. | ||
| S5038 | Valethamate Bromide | Valethamate bromide (Ediposin) is an alkylbenzene which is useful for facilitating cervical ripening, dilatation and thereby decreasing the duration of labor. | ||
| S6064 | Acid Yellow 23 | Acid Yellow 23 is a popular colorant for multiple applications, commonly used in ink, pond dyes, and textiles. | ||
| S6613 | Vanillylmandelic acid | Vanillylmandelic acid (VMA) is a chemical intermediate in the synthesis of artificial vanilla flavorings and is an end-stage metabolite of the catecholamines | ||
| S9827 | Iodoacetamide | Iodoacetamide (IA, IAM, 2-Iodoacetamide) is an alkylating agent that is commonly used for alkylation of cysteine during sample preparation for proteomics. | ||
| E1321 | Digitonin | Digitonin, a steroidal saponin and glycoside obtained from Digitalis purpurea, has strong lytic activity on various cell membranes with an IC50 of 15.1 µM on sheep RBC membranes. | ||
| S5173 | 2'-Hydroxy-4'-methylacetophenone | 2'-Hydroxy-4'-methylacetophenone may be used in the preparation of 4'-methyl-2'-[(p-tolylsulfonyl)oxy]acetophenone and possesses acaricidal property. | ||
| S4893 | Cytosine | Cytosine (4-Amino-2-hydroxypyrimidine, Cytosinimine) is one of the four main bases found in DNA and RNA used in storing and transporting genetic information within a cell. | ||
| S6207 | Levulinic acid | Levulinic acid (4-oxopentanoic acid, β-Acetylpropionic acid, 3-Acetopropionic acid, γ-ketovaleric acid) is used as a precursor for pharmaceuticals, plasticizers, and various other additives. | ||
| S6075 | Nepsilon-Acetyl-L-lysine | Nepsilon-Acetyl-L-lysine is an R-chain N-acetylated α amino acid used together with other lysine analogues to differentiate and characterized various aminoacylases and regulator 2 (Sir2) enzymes/sirtuins. | ||
| S4766 | Gibberellic acid | Gibberellic acid (Gibberellin, Gibberellin A3, GA3, GA), a plant hormone stimulating plant growth and development, is a tetracyclic di-terpenoid compound. | ||
| S4958 | Glycocholic acid | Glycocholic acid (Cholylglycine, Glycocholate) is a natural secondary bile acid involved in the emulsification of fats. | ||
| S5320 | Octinoxate | Octinoxate (Octyl methoxycinnamate, ethylhexyl methoxycinnamate) is a cinnamate ester and common ingredient in sunscreen and other skin care products to minimize DNA photodamage. | ||
| S9291 | Isopimpinellin | Isopimpinellin (5,8-Dimethoxypsoralen) is a natural product synthesized by numerous plant species. It may acts as an anticarcinogen. | ||
| S6208 | Diethyl malonate | Diethyl malonate, naturally occuring in grapes and strawberries, is used in the synthesis of chemicals. | ||
| S6082 | 8-Aminooctanoic acid | 8-Aminooctanoic acid is a chemical. | ||
| S3529 | Linerixibat | Linerixibat (GSK 2330672, GSK 672), a highly potent, nonabsorbable inhibitor of apical sodium dependent bile acid transporter (ABST), also known as the ileal bile acid transporter (IBAT), is used to the treatment of cholestatic pruritus in primary biliary Cholangitis. The IC50 of human ASBT is 42 nM. | ||
| E0502 | Metrizoic acid | Metrizoic acid(Metrizoate) is a diagnostic radiopaque. The mechanism of action of metrizoic acid is as a X-Ray contrast activity. | ||
| E7078New | N2,N2-Dimethylguanosine | N²,N²-Dimethylguanosine (m 2 2 G) is a key post-transcriptional modification found in tRNAs, where two methyl groups are added to the N² position of guanosine. This modification is essential for improving tRNA structural stability and functionality, particularly at positions like G26, which are critical for ensuring the correct conformation for efficient translation. Enzymes such as Trm1 (in yeast) and TRMT1 (in humans) catalyze the formation of m²₂G using S-adenosylmethionine (SAM) as a methyl donor. This modification supports cellular functions, modulates stress responses, and ensures proper translation efficiency. | ||
| E5772New | DC_AC50 | DC_AC50 is an inhibitor of the copper-trafficking proteins Atox1 (kd ∼6.8 µM) and full-length CCS (kd ∼8.2 µM) that significantly suppressing cell proliferation in various human cancer cell lines. | ||
| E6033New | Cilastatin sodium | Cilastatin sodium (MK0791 sodium) is a reversible, competitive inhibitor of renal dehydropeptidase I (also known as membrane dipeptidase, MDP), with an IC50 of 0.1 µM. It is primarily used in combination with imipenem to enhance the antibiotic's effectiveness against a broad spectrum of bacterial infections by preventing its degradation in the kidneys. | ||
| S6209 | Diethyl succinate | Diethyl succinate (Butanedioic acid diethyl ester) is the diethyl ester of succinate and acts as an irritant. | ||
| S6474 | 3,5-diiodo-L-thyronine (3,5-T2) | 3,5-diiodo-L-thyronine (3,5-T2, NSC 90469) is an endogenous metabolite of thyroid hormones. 3,5-Diiodo-l-thyronine has been proposed as a potential hypolipidemic agent for treatment of obesity and hepatic steatosis.The solubility of this product is not good, please choose carefully for cell experiments! | ||
| E2878 | iothalamate sodium | Iothalamate sodium is the sodium salt form of iothalamate, an organic iodine compound and a radiographic contrast medium. | ||
| E4808New | Propionyl-L-carnitine hydrochloride | Propionyl-L-carnitine hydrochloride(Levocarnitine propionate hydrochloride) supports mitochondrial metabolism, offers cardiovascular benefits, acts as a free radical scavenger, and is used in treating colonic inflammatory bowel disease. | ||
| S3947 | Hydroumbellic acid | Hydroumbellic acid (2,4-Dihydroxyhydrocinnamic acid) is used as pharmaceutical intermediates. | ||
| S4820 | Diastase | Diastase, a natural enzyme, catalyses the breakdown of starch into maltose. | ||
| S9468 | Colestipol Hydrochloride | Colestipol hydrochloride, a salt form of Colestipol, is a high-molecular-weight, insoluble, granular copolymer of tetraethylenepentamine and epichlorohydrin. It functions as an anion-exchange and resin-sequestering agent. Colestipol hydrochloride reduces cholesterol levels without affecting triglycerides. | ||
| S6103 | Inosine 5′-triphosphate trisodium salt | Inosine 5′-triphosphate (ITP) is used in studies on the impact of deamination of ATP and GTP by various enzymes and chemical processes. | ||
| S5937 | DL-Carnitine | DL-Carnitine ((±)-Carnitin) is a racemic mixture of L-Carnitine and D-Carnitine that regulates fatty acid transport in the mitochondrion. DL-carnitine is found to be ineffective or toxic, for example, to muscle cells and to the myocardium. DL-Carnitine causes symptoms of myasthenia and cardiac arrhythmias. | ||
| S2422 | Ipriflavone (Osteofix) | Ipriflavone (7-Isopropoxyisoflavon) is used to inhibit bone resorption. | ||
| S4608 | L-Tyrosine | L-tyrosine ((S)-Tyrosine, P-Tyrosine, L-p-Tyrosine) is a non-essential amino acid. In animals it is synthesized from Ephenylalanine. | ||
| E0428New | IMP-1088 | IMP-1088 is a potent dual inhibitor of human N-myristoyltransferases NMT1 and NMT2, with an IC50 of <1 nM for HsNMT1 and HsNMT2 and a Kd of <210 pM for HsNMT1. It effectively inhibits the production of infectious rhinovirus virions by blocking the N-myristoylation of the rhinovirus VP0 protein. | ||
| E0752 | Paederoside | Paederoside is a monoterpene S-methyl thiocarbonate isolated from Paederia pertomentosa and inhibits Epstein-Barr virus (EBV) early antigen (EA). | ||
| E2382 | (Rac)-IBT6A | (Rac)-IBT6A (BTK inhibitor 1) is a racemate of IBT6A and an impurity of Ibrutinib, which is a Btk inhibitor (IC50=0.5 nM), and can be used in the synthesis of IBT6A Ibrutinib dimer and IBT6A adduct. | ||
| E7081New | Purpurin 18 | Purpurin-18 is a chlorophyll-derived dihydroporphyrin, serves as a key precursor for photosensitizers like purpurinimides, which absorb light in the 700–850 nm range. It demonstrate potent photodynamic anti-tumor activity and generates ROS, disrupting mitochondrial membrane potential and inducing apoptosis against triple-negative breast cancer both in vitro and in vivo. | ||
| S6216 | 1-Methylpyrrolidine | 1-Methylpyrrolidine is extensively used in the synthesis of pyrrolidine based ionic liquids. | ||
| S6116 | N-Acetylornithine | N-Acetylornithine is an intermediate in the enzymatic biosynthesis of the amino acid L-arginine from L-glutamate. It is a minor component of deproteinized blood plasma of human blood. | ||
| E1951New | X5050 | X5050 is a benzoimidazole-5-carboxamide derivative and a potent inhibitor of repressor element-1 silencing transcription factor (REST) with an EC50 of 2.1 μM. It can be used in research of Huntington's disease and other neurodegenerative disorders characterized by altered BDNF levels. | ||
| S3779 | cis-Anethole | Anethole ((Z)-Anethole, Cis-p-Propenylanisole, Cis-p-Anethole) has two isomers, the cis(Z) isomer being 15-38 times more toxic to animal than the trans(E) isomer. cis-Anethole is found in anise and Only a low level is permitted in flavours. | ||
| S4815 | L-Cysteine HCl | L-cysteine Hydrochloride, also known as L-CYSTEINE or Cysteine HCL (anhydrous), is classified as a cysteine or a cysteine derivative that increases glutathione levels and is important for lung and brain function and liver detoxification. | ||
| S5450 | Sofalcone | Sofalcone (SU-88) is an antiulcer drug and a mucosal protective agent, increasing vascular endothelual growth factor via the Nrf2-heme-oxygenase-1 dependent pathway in gastric epithelial cells. | ||
| S6223 | Triethyl citrate | Triethyl citrate (Ethyl citrate, E1505, Citric acid ethyl ester) is used in pharmaceutical coatings and plastics. | ||
| S6120 | Glycyl-L-valine | Glycyl-L-valine (H-Gly-Val-OH, Glycylvaline) is a dipeptide composed of glycine and valine. It is an incomplete breakdown product of protein digestion or protein catabolism. | ||
| S4633 | Isosorbide Mononitrate | Isosorbide mononitrate (Elantan, Monoket, Mononit, Imdur, Corangin) is a Nitrate Vasodilator, dilating the blood vessels so as to reduce the blood pressure. | ||
| S5340 | 3-Aminopropionitrile fumarate | 3-Aminopropionitrile fumarate (Beta-Aminopropionitrile fumarate) is an organic compound and antirheumatic agent used in veterinary medicine. | ||
| S5706 | Edetate Trisodium | Edetate Trisodium (EDTA trisodium salt, ethylenediaminetetraacetic acid) is the organic sodium salt of ethylenediaminetetraacetic acid (EDTA). EDTA is a chelating agent capable of removing a heavy metal, such as lead or mercury, from the blood. | ||
| S6225 | 10-Undecen-1-ol | 10-Undecen-1-ol is used as a flavoring agent. | ||
| S6128 | L-Homocitrulline | L-Homocitrulline (N(6)-carbamoyl-L-lysine) is an amino acid and a metabolite of ornithine in mammalian metabolism. | ||
| E2879 | Lapyrium chloride | Lapyrium chloride(NSC-33659) is used as a cosmetic ingredient, cationic emulsifier, detergent-germicide, deodorant and anti-static agent. | ||
| E1317New | LY 345899 | LY345899 is a Folate analog and a potent inbhibitor of methylene tetrahydrofolate dehydrogenase1 (MTHFD1; DC301) and methylene tetrahydrofolate dehydrogenase2 (MTHFD2) with IC50 values of 96 nM and 663 nM, respectively. It significantly suppresses tumor growth and reduces tumor weight in CRC patient-derived xenograft models. | ||
| S5387 | D-Tagatose | D-Tagatose is an isomer of fructose and is used as a sweetener in beverages, yogurt, creams, and dietetic candy. | ||
| S5798 | Pyriproxyfen | Pyriproxyfen (S-31183) is an insect growth regulator that has been widely used worldwide as a larvicide in vector control and in agriculture to fight a very large number of pests. | ||
| S2997 | Tartaric acid | Tartaric Acid (2,3-Dihydroxysuccinic acid) is a white, crystalline organic acid isolated from many plants, particularly tamarinds and grapes and is used as an antioxidant and an additive agent to give a sour taste. |
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| S3782 | Neomangiferin | Neomangiferin (Mangiferin 7-glucoside), a natural xanthone C-glycoside mainly obtained from the well-known traditional Chinese medicine rhizoma of Anemarrhena asphodeloides, exhibits antidiabetic activity and antiosteoporotic action. | ||
| S5342 | Dihydrojasmone | Dihydrojasmone, belonging to the family of ketones, is an aroma compound for perfumery uses. | ||
| S6133 | H-Gly-Pro-OH | H-Gly-Pro-OH (Glycyl proline, Glycyl-L-proline) is a dipeptide composed of glycine and proline, and is an end product of collagen metabolism that is further cleaved by prolidase. The resulting proline molecules are recycled into collagen or other proteins. | ||
| S5339 | 4-Allylanisole | 4-Allylanisole (Estragole, p-Allylanisole, Methyl chavicol) is a natural organic compound that is a component of various trees and plants. It is used in the preparation of fragrances. | ||
| S9008 | 20-Deoxyingenol | 20-Deoxyingenol is a natural compound isolated from the seeds of Euphorbia lathyris L. | ||
| S6134 | 3-Aminoisobutyric acid | 3-Aminoisobutyric acid (3-Amino-2-methylpropanoic acid, 3-Aminoisobutyrate, β-aminoisobutyric acid) is a product formed by the catabolism of thymine. | ||
| S6566 | NSC23005 Sodium | NSC 23005 is a small molecule inhibitor of p18 (ED50=5.21 nM). | ||
| S8145New | Plicamycin | Plicamycin (Mithramycin A) a selective inhibitor of Sp1, is a natural polycyclic aromatic polyketide isolated from Streptomyces strains. It binds to GC-rich DNA sequences, displacing Sp1 transcription factor from oncogene promoters, inhibiting their expression, with anti-tumor and neuroprotective effects. | ||
| S3092 | Glyoxylic acid monohydrate | Glyoxylic acid monohydrate (2,2-Dihydroxyacetic acid) is an atmospherically relevant ketoacid. |
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| S9301 | Verbenalin | Verbenalin (Verbenalol β-D-glucopyranoside, Verbenalol glucoside, Cornin), an iridoid glycoside found in Verbena officinalis, has been reported to exhibit uterine stimulant activity and demonstrated cardioprotection against experimental myocardial ischemic injury. | ||
| S6137 | 4-Guanidinobutanoic acid | 4-Guanidinobutanoate (4-Guanidinobutanoate, gamma-Guanidinobutyric acid, gamma-Guanidinobutanoate) is a normal metabolite present in low concentrations. | ||
| S3093 | Pyrazole | Pyrazole (1H-pyrazole) is a five membered heteroaromatic ring with two nitrogen atoms is of immense significance. Pyrazole is an indispensable anchor for design and development of new pharmacological agents. |
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| E0104 | Centhaquin | Centhaquin (Centhaquine, PMZ-2010), a potential agent for treatment of haemorrhagic shock, can augment cardiac output, reduce systemic vascular resistance in haemorrhagic models. | ||
| S4173 | 1-Hexadecanol | 1-Hexadecanol is a fatty alcohol used to make other chemicals. | ||
| S5603 | 5-Bromocytosine | 5-Bromocytosine can be used in the synthesis of cross-link products under anaerobic and aerobic conditions. | ||
| S6141 | Anserine | Anserine (β-alanyl-N-methylhistidine) is a dipeptide containing β-alanine and 1-methylhistidine. It is normally absent from human tissues and body fluids, and its appearance there is an artifact of diet and serum carnosinase deficiency. | ||
| S3094 | N-Acetyl-L-alanine | N-Acetyl-L-alanine (NAAL, Ac-Ala-OH) is an active endogenous metabolite. |
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| S4174 | Sodium Gluconate | Sodium gluconate is the sodium salt of gluconic acid widely used in food and pharmaceutical industry. | ||
| S5344 | 1,4-Diaminobutane dihydrochloride | 1,4-Diaminobutane (Putrescine, Tetramethylenediamine, 1,4-Butanediamine) is used as a precursor in many biological systems and synthon for amido-ureas. | ||
| S5606 | Sulfamide | Sulfamide (Sulfuric diamide) is used in organic chemistry for synthesis. | ||
| S9011 | Hederacoside D | Hederacoside D is one of the major bioactive saponins and plays pivotal roles in the overall biological activity. | ||
| S6142 | 3-Amino-4-methylpentanoic acid | 3-Amino-4-methylpentanoic acid (beta-Leucine, DL-Homovaline, DL-beta-leucine, beta-Aminoisocaproic acid) is a human metabolite. | ||
| S3157 | 3-Hydroxybenzaldehyde | 3-Hydroxybenzaldehyde (3-HBA), one of the benzaldehydes commonly found in nature, is produced by 3-hydroxybenzyl-alcohol dehydrogenase, and is a substrate of aldehyde dehydrogenase (ALDH) in rats and humans (ALDH2). 3-Hydroxybenzaldehyde exhibits vasculoprotective effects. |
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| E0649 | ADAMTS-5 Inhibitor | ADAMTS-5 Inhibitor is a potent ADAMTS-5 (aggrecanase-2) inhibitor, with an IC50 of 1.1 µM. | ||
| S5346 | 2-Phenylethylamine hydrochloride | 2-Phenylethylamine hydrochloride (β-Phenylethylamine, benzeneethanamine, β-aminoethylbenzene) is the hydrochloride salt form of 2-Phenylethylamine, which is an aromatic amine acting as a monoaminergic neuromodulator or a neurotransmitter in the human central nervous system. | ||
| S9012 | Khasianine | Khasianine is a natural product isolated from the herbs of Solanum nigrum L. and exhibits strong activity against liver damage induced by CCl4. | ||
| S6153 | L-Leucyl-L-alanine Hydrate | L-Leucyl-L-alanine Hydrate (H-Leu-Ala-OH) is a dipeptide composed of L-leucine and L-alanine joined by a peptide linkage. It is a metabolite. | ||
| S0989 | ML-180 | ML-180 (SR1848) is a potent inverse agonist of orphan nuclear receptor NR5A2 (Liver receptor homologue-1, LRH1) with IC50 of 3.7 μM. ML-180 has the potential for LRH-1-dependent cancers. | ||
| E0117 | Deferitrin | Deferitrin(GT-56-252) is a novel oral iron chelator for the treatment of chronic iron overload due to blood transfusion therapy. | ||
| E0652 | 2-Hydroxyisocaproic acid | 2-hydroxyisocaproic acid (HICA), an amino acid derivative, has broad antibacterial activity. | ||
| E1332 | EG-011 | EG-011 is a potent Wiskott-Aldrich syndrome protein (WASP) activator. | ||
| E4445 | 3-Benzoylpropionic acid | 3-Benzoylpropionic acid is a carboxylate compound which can be used as a fungicide and an oligonucleotide synthesis reagent. | ||
| S4973 | Iminostilbene | Iminostilbene (2,3,6,7-Dibenzazepine) is a chemical precursor of carbamazepine which is used primarily in the treatment of epilepsy and neuropathic pain. | ||
| S5602 | Gallocyanine | Gallocyanine (Solid Violet) is a histological dye used in solution with an iron alum mordant as a hematoxylin substitute in the H&E stain. It has a role as a fluorochrome and a histological dye. | ||
| S5907 | 5-Methyl-2'-deoxycytidine | 5-Methyl-2'-deoxycytidine (5-Me-dC, 5-Methyldeoxycytidine, 5MedCyd) is a minor component found in most eukaryotic DNA. | ||
| S6176 | Scyllo-Inositol | Scyllo-Inositol (Scyllitol, Cocositol, Quercinitol, AZD 103, Scyllo-Cyclohexanehexol) is a naturally occurring plant sugar alcohol found most abundantly in the coconut palm. | ||
| S0801 | Spastazoline | Spastazoline is a potent, cell-permeable and selective spastin (a microtubule-severing AAA (ATPases associated with diverse cellular activities) protein) inhibitor with IC50 of 99 nM for Human spastin. Spastazoline does not inhibit ATPase activity of a recombinant human VPS4 (another AAA protein required for intercellular bridge disassembly). | ||
| S3334 | Glycolaldehyde dimer | Glycolaldehyde dimer (2,5-Dihydroxy-1,4-dioxane, 1,4-Dioxane-2,5-diol, DD) is an active endogenous metabolite that appears moderate absorbent and fluorescent, when it reacts with glycine (Gly)/ammonium sulfate (AS). |
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| E2885 | Suc-Ala-Ala-Pro-Phe-pNA | Suc-Ala-Ala-Pro-Phe-pNA(Suc-AAPF-pNA) is a chromogenic p-nitroanilide (pNA) substrate with the Km of 1.7 mM. | ||
| E4312 | CSRM617 hydrochloride | CSRM617 hydrochloride is a selective small-molecule inhibitor of the transcription factor ONECUT2 (OC2, a master regulator of androgen receptor) with a Kd of 7.43 uM in SPR assays, binding to OC2-HOX domain directly. It induces apoptosis by appearance of cleaved Caspase-3 and PARP and is well tolerated in the prostate cancer mouse model. | ||
| E4294 | (-)-CAMPHOR | (-)-CAMPHOR is obtained from the wood of the camphor tree and is used as a remedy for treating a variety of symptoms such as inflammation, ingestion, infection, congestion, pain, and irritation. Few components of the camphor tree have suppressive and antimutagenic effects on a number of human cancer cells without harming the healthy cells. | ||
| S4057 | Methyclothiazide | Methyclothiazide is a substituted benzothiadiazide, used to treat high blood pressure and fluid retention caused by various conditions including heart disease. | ||
| S4177 | Uracil | Uracil is one of the four nucleobases in the nucleic acid of RNA can be used for drug delivery and as a pharmaceutical. | ||
| S4968 | Cholesteryl Acetate | Cholesteryl Acetate (Acebrochol, Cholesterol, Cholesterin), present in diverse fluids, organs, and foods, is a natural and normal human cholesteryl ester. | ||
| S5605 | Tos-Arg-OMe HCl | Tos-Arg-OMe HCl, a kind of amino acid derivatives, is a substrate for trypsin, plasmin, thrombin and orther proteases. | ||
| S6201 | Malachite green | Malachite green (Aniline green, Basic green 4, Diamond green B, Victoria green B) is a synthetic dyestuff and antimicrobial with potential carcinogenicity. | ||
| S5610 | Indole-3-acetamide | Indole-3-acetamide (3-Indolylacetamide) is an auxin precursor that is also used in the synthesis of indole-3-acetic acid. | ||
| S6260 | (S)-(−)-α-Methylbenzylamine | (S)-(−)-α-Methylbenzylamine is a chiral auxiliary in the enantiodivergent synthesis of simple isoquinoline alkaloids. | ||
| S6203 | H-Abu-OH | H-Abu-OH (2-Aminobutyric acid, 2-Aminobutanoic acid, Homoalanine, α-Aminobutanoic acid, Ethylglycine) is a non-proteinogenic alpha amino acid that is used by nonribosomal peptide synthases. | ||
| S3337 | L-Histidinol dihydrochloride | L-Histidinol dihydrochloride, a structural analogue of the essential amino acid L-histidine, is a reversible inhibitor of protein biosynthesis which evokes disparate responses from non-tumorigenic and tumorigenic cells in culture. |
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| S4830 | Maltose | Maltose (Maltobiose, Malt Sugar, Beta-Maltose, D-Maltose), an non-essential nutrient that provides energy, is an intermediate in the intestinal digestion of glycogen and starch, and is found in germinating grains (and other plants and vegetables). | ||
| S6263 | Glycerol Tributyrate | Glycerol tributyrate (Tributyrin) is a triglyceride that may inhibit cell growth and induce cell differentiation. | ||
| S3338 | D-(-)-Lyxose | D-(-)-Lyxose (D-Lyxose) is an active endogenous metabolite. |
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| E4610New | SMIP34 | SMIP34 is a small molecule inhibitor of proline, glutamic acid, and leucine-rich protein 1 (PELP1). It is effective in reducing cell viability, reducing invasion, and inducing apoptosis in Triple-negative breast cancer (TNBC) models. | ||
| S4860 | Indole-3-carboxylic acid | Indole-3-carboxylic acid (3-Indoleformic acid, 3-Carboxyindole, β-Indolylcarboxylic acid, 3-indolecarboxylate, 3-indoleformate) is a normal urinary indolic tryptophan metabolite which belongs to a class of organic compounds known as indolecarboxylic acids and derivatives. | ||
| S5497 | Iopanoic acid | Iopanoic acid (Acidum iopanoicum, Iodopanoic acid) is an iodine-containing radiocontrast medium used in cholecystography. | ||
| S6265 | γ-caprolactone | γ-caprolactone is well-known as a food flavor and is a biostimulant molecule promoting the growth of bacteria with biocontrol activity against soft-rot pathogens. | ||
| S3345 | Nα-Acetyl-L-lysine | Nα-Acetyl-L-lysine (Ac-Lys-OH, N(alpha)-Acetyllysine) is an active endogenous metabolite. |
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| E1248 | p-Nitrobenzyl mesylate | p-Nitrobenzyl mesylate is an alkylating reagent for direct kinase substrate identification. | ||
| E4299 | Chitosan | Chitosan(Deacetylated chitin (MW 150000); Poly(D-glucosamine) (MW 150000)) is a polycationic linear polysaccharide derived from chitin with the molecular weight of 150000. Chitosan is an versatile biomaterial because of its non-toxicity, low allergenicity, biocompatibility and biodegradability. Chitosan also has antitumor, antibacterial, antifungal, and antioxidant activities. | ||
| S4816 | Diatrizoate sodium | Diatrizoate sodium (Amidotrizoate sodium, Hypaque sodium, Triombrin) is an iodinated radiopaque X-ray contrast medium that is used as a diagnostic aid in angiography, urography and radiography. | ||
| S3347 | 3-Methylglutaric acid | 3-Methylglutaric acid (MGA, 3MG acid) is a conspicuous C6 dicarboxylic organic acid that can be used as a single solid-state NMR standard compound to perform all calibration steps except for magnet shimming. |
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| S9787 | Conoidin A | Conoidin A is a covalent inhibitor of peroxiredoxin II with an IC50 of 25.1 mM for recombinant T. gondii enzyme peroxiredoxin II (rTgPrxII). | ||
| E2892 | L-ALANYL-L-TYROSINE | L-ALANYL-L-TYROSINE(H-Ala-Tyr-OH) is a tyrosine derivative. | ||
| S6274 | 2-Methyltetrahydrofuran-3-one | 2-Methyltetrahydrofuran-3-one is a volatile constituent of the aroma complex of roasted coffee. | ||
| S3348 | O-Acetyl-L-serine hydrochloride | O-Acetyl-L-serine (OAS, O-Acetylserine, O-Acetyl-L-serine) hydrochloride (HCl) is an intermediate in the biosynthesis of the amino acid cysteine in bacteria and plants that displays a signalling function leading to changes in transcript levels of a specific gene set irrespective of the sulfur status of the plant. |
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| E2377 | 2′-O-(2-Methoxyethyl)guanosine | 2′-O-(2-Methoxyethyl)guanosine (2'-O-MOE-rG), a 2′-O-methoxyethyl-modified nucleoside, can be produced by enzymatic conversion (adenosine deaminase) from 2′-O-(2-methoxyethyl)-2,6-diaminopurine riboside. | ||
| S2402 | Cyclovirobuxine D | Cyclovirobuxine D (Cyclovirobuxin D, Cyclovirobuxine, Bebuxine, CVB-D) is an active compound extracted from Buxus microphylla, which has been used for treating acute myocardial ischemia. | ||
| S3651 | 4-Amino-5-imidazolecarboxamide | 4-Amino-5-imidazolecarboxamide is an imidazole derivative which is a metabolite of the antineoplastic agents BIC and DIC. By itself, or as the ribonucleotide, it is used as a condensation agent in the preparation of nucleosides and nucleotides. | ||
| S3912 | Cephalotaxine | Cephalotaxine is a naturally occurring alkaloid which is the structural motif of a number of compounds and has shown promising anti-cancer properties. | ||
| S5436 | 2-Hydroxycaprylic acid | 2-Hydroxycaprylic acid (2-hydroxyoctanoic acid) belongs to the class of organic compounds known as medium-chain fatty acids. | ||
| S9314 | Atractylenolide II | Atractylenolide II (AT-II, Asterolide, 2-Atractylenolide), a major sesquiterpenoids isolated from the dried Rhizome of Atractylodes macrocephala, shows a wide range of biological and pharmacological activities, for example, against insomnia and anxiety, neuroprotective, platelet activation and anti-cancer effect. | ||
| S6275 | (−)-β-Pinene | (−)-β-Pinene (Nopinene) is a natural organic compound in various plants. It is lethal to S. littoralis third instar larvae (LD50 = 65 μg/larva), inhibits infectious bronchitis virus (IBV) replication (IC50 = 1.32 mM) and exhibits a cytotoxic concentration (CC50) value of greater than 10 mM in Vero cells. | ||
| S3358 | 4-Acetamidobutyric acid | 4-Acetamidobutanoic acid (N-acetyl GABA) is a derivative of Gamma-aminobutyric acid (GABA) resulting from the monoacetylation of the nitrogen of GABA. |
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| S3538 | CEBPα inducer 1 | C/EBPα inducer 1 (compound 78) is a potent inducer of CCAAT enhancer-binding protein α (C/EBPα) and myeloid differentiation. | ||
| S4624 | 5,5-Dimethyloxazolidine-2,4-dione | 5,5-Dimethyloxazolidine-2,4-dione (Dimethadione, Dimethyloxazolidinedione, Dimethadion) is an anticonvulsant that is the active metabolite of trimethadione. | ||
| S3914 | α-Hederin | α-hederin is a water-soluble pentacyclic triterpenoid saponin which has shown hemolytic and apoptotic properties. | ||
| S5503 | O-Acetyl-L-carnitine hydrochloride | O-Acetyl-L-carnitine (Acetyl-L-carnitine, O-acetyl-L-carnitine, O-Acetylcarnitine) can be synthesis or is naturally found in healthy humans. It could help transport fatty acids into the mitochondrial matrix where fatty acid metabolism occurs. | ||
| S6276 | Bicine | Bicine (N,N-Bis(2-hydroxyethyl)glycine, Diethylolglycine, Diethanol glycine, Dihydroxyethylglycine) is an organic compound used as a buffering agent. | ||
| E2893 | Triton X-114 | Triton(TM) X-114 (Triton X-114) is a nonionic detergent used in biochemical applications for solubilizing and separation of intrinsic membrane proteins because of its reversible phase separation property. | ||
| S2306 | Gynostemma Extract | Gynostemma Extract (Gynostemma Pentaphyllum, Gypenoside) is a saponins extract derived from the Gynostemma pentaphyllum. | ||
| S9316 | Polyphyllin II | Polyphyllin II, a natural compound extracted from Rhizoma of Paris polyphyllin, shows hemolytic activity. | ||
| S6278 | 4-Methylvaleric acid | 4-Methylvaleric acid (Isocaproic acid, Isocaproate, 4-Methylpentanoate, 4-Methylpentanoic acid) is an important metabolite in early placentas enabling the convertion from cholesterol to pregnenolone to Dehydroepiandrosterone (DHEA). | ||
| S6290 | D-Fructose-1,6-diphosphate trisodium salt octahydrate | D-Fructose-1,6-diphosphate trisodium salt octahydrate (FBP trisodium salt octahydrate), a common metabolic sugar, is the precursor of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate in the glycolytic pathway. | ||
| S6588 | Methylprednisolone hemisuccinate | Methylprednisolone sodium succinate is a glucocorticoid used to treat a variety health issues including severe allergic reactions, asthma, autoimmune diseases, blood disorders, gastrointestinal diseases and endocrine disorders. | ||
| E7096New | Insulin(cattle) | Insulin(cattle) is a two-chain polypeptide hormone produced by pancreatic β cells and commonly used as a growth supplement in cell culture. Its native structure is crucial for receptor interaction, regulating glucose homeostasis, while its stable hexameric form or analogs are used for storage and injection. | ||
| S3916 | Macranthoidin B | Macranthoidin B (Macranthoiside I) is a major bioactive saponin in rat plasma after oral administration of extraction of saponins from Flos Lonicerae. | ||
| S5347 | 2-Phenylethylamine | 2-Phenylethylamine (β-Phenylethylamine, benzeneethanamine, β-aminoethylbenzene) is a natural monoamine alkaloid that functions as a monoaminergic neuromodulator or a neurotransmitter in the human central nervous system. | ||
| S6279 | Cyclohexanecarboxylic Acid | Cyclohexanecarboxylic Acid, a component of the growth stimulant naphthenic acid, is the starting reagent for the synthesis of polyketide-type antibiotics, Phoslactomycins. | ||
| S6302 | L(-)-Pipecolinic acid | L(-)-Pipecolinic acid (L-Homoproline) is a normal human metabolite present in human blood. | ||
| S6589 | Norethisterone Enanthate | Norethisterone Enanthate (Norethindrone Enanthate) is a form of progestogen-only injectable birth control which is used to prevent pregnancy in women. | ||
| S0564 | SPDP | SPDP is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable disulfide bonds with cysteine sulfhydryls. SPDP is a glutathione cleavable ADC linker used for the antibody-drug conjugates (ADCs). | ||
| E0745 | AA147 | AA147, a small molecule endoplasmic reticulum (ER) proteostasis regulator, selectively activates ATF6 arm of the unfolded protein response (UPR) extracted from patent WO2017117430A1, compound 147*. | ||
| S3920 | 7β-Hydroxylathyrol | 7β-Hydroxylathyrol (7beta-Hydroxylathyrol, 7-Hydroxylathyrol) is natural occuring product extracted from the seeds of Euphorbia lathyris L. | ||
| S5348 | Pherocon (4-(4-Acetoxyphenyl)-2-butanone) | Pherocon (4-(4-Acetoxyphenyl)-2-butanone, 4-(p-Acetoxyphenyl)-2-butanone, 4--(3-Oxobutyl)phenyl acetate) is a standard melon fly attractant for detection programs. | ||
| S9026 | Hastatoside | Hastatoside is a characteristic constituent of V. officinalis and exhibit various biological activities including sleep-promoting, antioxidant and hepatoprotective activity. | ||
| S6306 | Guanosine 5'-monophosphate disodium salt | Guanosine 5′-monophosphate (GMP, 5'-Guanylic acid, guanylic acid, guanosine monophosphate) is a ribonucleoside monophospate which upon phosphorylation to GTP becomes incorporated into ribonucleic acids (RNAs) by various RNA polymerase(s). | ||
| E2906 | Tetrazolium Red | Tetrazolium Red(2,3,5-Triphenyltetrazolium chloride, TPTZ, TTC) is a dye and has been successfully used for early histochemical diagnosis of myocardial infractions. | ||
| S3921 | Lathyrol | Lathyrol is a natural product that is used for cancer treatment. | ||
| S4972 | Choline Glycerophosphate | Choline Glycerophosphate (Glycerophosphorylcholine) is a choline derivative and one of the two major forms of choline storage (along with phosphocholine) in the cytosol. | ||
| S9319 | Cryptochlorogenic acid | Cryptochlorogenic acid (4-Caffeoylquinic acid, 4-O-Caffeoylquinic acid), a phenolic acid found in various plant species, including Artemisia, honeysuckle, and H. sabdariffa, possesses antioxidant properties. | ||
| S6287 | 3-Methylbutanoic acid | 3-Methylbutanoic acid (Isovaleric acid, Delphinic acid, 3-Methylbutyric acid, Isopentanoic acid, β-methylbutyric acid) is a natural fatty acid found in a wide variety of plants and essential oils. It has a strong pungent cheesy or sweaty smell, but its volatile esters have pleasing scents and are used widely in perfumery. | ||
| S6315 | Sodium phytate hydrate | Sodium phytate hydrate (Phytic acid, Dodecasodium phytate, Myo-inositol hexakis, Inositol hexakisphosphate) functions as a storage depot and precursor for other inositol phosphates and pyrophosphates. It can be used clinically as a hypocalcemic agent and a complexing agent for removal of traces of heavy metal ions. | ||
| E0620 | LIT-001 trifluoroacetate | LIT-001 trifluoroacetate(LIT-001 TFA) is the first nonpeptide oxytocin receptor (OXTR) agonist that improves social interaction in a mouse model of autism. | ||
| S4899 | Sulfogaiacol | Sulfogaiacol (Guaiacolsulfonate) is a antitussive agent that is used for acute respiratory tract infections, cough and other conditions. | ||
| S6296 | Octanoic acid | Octanoic acid (caprylic acid) is found naturally in the milk of various mammals, and as a minor constituent of coconut oil and palm kernel oil. It is used in the production of esters used in perfumery and also in the manufacture of dyes. | ||
| S0792New | Varoglutamstat | Varoglutamstat (PQ912) is an inhibitor of glutaminyl cyclase (QC), inhibiting human glutaminyl cyclase (hQC) activity with a Ki of 25 nM (pH 8.0). It reduces pyroglutamyl-Aβ (pE-Aβ) levels and can be used in Alzheimer's disease research. | ||
| E0621 | FGFR1/DDR2 inhibitor 1 | FGFR1/DDR2 inhibitor 1 is an inhibitor of fibroblast growth factor receptor 1 (FGFR1) and discoidin domain receptor 2 (DDR2). | ||
| S9322 | Neodiosmin | Neodiosmin (Diosmetin-7-neohesperidoside, Diosmetin-7-O-neohesperidoside), a flavone glycoside isolated from C. aurantium, is a strong antioxidant with potential applications in foods, beverages, and pharmaceutical preparations. | ||
| S6298 | 2,5-Dimethyl-2,3-dihydrofuran-3-one | 2,5-Dimethyl-2,3-dihydrofuran-3-one is a chemical. | ||
| S6325 | Adenosine 5′-diphosphate sodium salt | Adenosine 5′-diphosphate (ADP, Adenosine diphosphate, Adenosine 5′-pyrophosphate, Adenosine pyrophosphate) is an important organic compound in metabolism and is essential to the flow of energy in living cells. ADP can be interconverted to adenosine triphosphate (ATP) and adenosine monophosphate (AMP). | ||
| S3096 | L-Histidine monohydrochloride monohydrate | L-Histidine monohydrochloride monohydrate (L-Histidine hydrochloride hydrate, H-His-OH.HCl.H2O), a structural analogue of the essential amino acid L-histidine, is a reversible inhibitor of protein biosynthesis which evokes disparate responses from non-tumorigenic and tumorigenic cells in culture. |
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| E2896 | 3,4-Dichlorophenyl isothiocyanate | 3,4-Dichlorophenyl isocyanate(1,2-Dichloro-4-isothiocyanatobenzene) is a chemical compound used as a chemical intermediate and in organic synthesis. | ||
| S4190 | Cinchophen | Cinchophen(Cinconal) is an analgesic drug that is frequently used to treat gout. | ||
| S6299 | Methyl cyclohexanecarboxylate | Methyl cyclohexanecarboxylate (Hexahydrobenzoic acid methyl ester, Methyl hexahydrobenzoate) is a flavouring ingredient and is used as a material for chemical synthesis. | ||
| S6330 | D(-)-2-Aminobutyric acid | D(-)-2-Aminobutyric acid is an unnatural amino acid serving as an important intermediate in pharmaceutical production. | ||
| S3098 | N-Acetylglycine | N-Acetylglycine (NAGly, Aceturic acid, Acetamidoacetic acid), a minor constituent of numerous foods, is not genotoxic or acutely toxic. |
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| E2907 | 1-Thioglycerol | 1-Thioglycerol(Mercaptopropanedioltech) is an inhibitor of glycerol kinase activity. It stimulates the synthesis of porphyrin in aerobically growing Escherichia coli. | ||
| S4897 | Nortropine Hydrochloride | Nortropine Hydrochloride (Nortropeno) is a secondary metabolite of tropine derivative drugs, such as atropine and benztropine. | ||
| S9334 | 2-Pentylfuran | 2-Pentylfuran (2-Amylfuran) is a naturally occuring flavouring ingredient. | ||
| S6303 | trans-2-Hexenal | Trans-2-hexenal (Leaf aldehyde) is an α,β-unsaturated carbonyl compound protecting plants against harmful substances. | ||
| S6587 | Clobetasone butyrate | Clobetasone butyrate is a new corticosteroid that is often employed topically as a treatment for a variety of conditions such as eczema, psoriasis, various forms of dermatitis, and also for certain ophthalmologic conditions. | ||
| S1031 | 3-Hydroxybutyric acid (BHB) | 3-Hydroxybutyric acid (BHB) is a small molecule metabolite that is elevated in type I diabetes. | ||
| S6932New | Senaparib | Senaparib(IMP4297, JS109) is a potent, selective and orally active PARP1/2 inhibitor with strong antitumor activity in preclinical studies. | ||
| S3097 | 5,6-Dimethylbenzimidazole | 5,6-Dimethylbenzimidazole (5,6-DMB, Dimezol, Dimedazol, 5,6-Dimethyl-1H-benzo[d]imidazole, 5,6-Dimethyl-1H-benzimidazole) is a vitamin B12 precursor. |
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| S3547 | Bractoppin | Bractoppin, a drug-like inhibitor of phosphopeptide recognition by the human BRCA1 tandem (t)BRCT domain, which selectively inhibits substrate binding with nanomolar activity (IC50 = 0.074 μM) in vitro. | ||
| E0505 | Olive oil | Olive oil comes from the fruits of Olea europae trees with a beneficial effect on human health, including the antioxidant activity and anti-inflammatory activity when olive oil is in regular diet. | ||
| S4658 | Hydroquinidine | Hydroquinidine (Dihydroquinidine, Hydroconchinine, Hydroconquinine, Dihydroquinine) is an antiarrhythmic agent. | ||
| S3933 | 10-deacetyl-paclitaxel | 10-deacetyl-paclitaxel (10-DAT, Deacetyl Paclitaxel) is a semi-synthetic precursor of Paclitaxel. | ||
| S4824 | Pentetic Acid | Pentetic Acid (Diethylenetriaminepentaacetic acid, DTPA, Acidum penteticum, Detapac, Detarex) is an aminopolycarboxylic acid that is used similar to EDTA, sequestering metal ions. | ||
| S9329 | Orcinol | Orcinol (5-Methylresorcinol; 3,5-ToluenediolOrcin; 5-Methyl-1,3-benzenediol; 3,5-Dihydroxytoluene), occurs in many species of lichens including Roccella tinctoria and Lecanora, exhibits antimutagenic, antioxidant, antibacterial, radical-scavenging effects. | ||
| S6311 | Dimethyl Trisulfide | Dimethyl trisulfide (Methyl trisulfide, DMTS, 2,3,4-trithiapentane) is an organic chemical compound and the simplest organic trisulfide. | ||
| S6420 | AGI 1067 | AGI-1067 is a novel, phenolic, intra- and extracellular antioxidant that inhibits the expression of a number of proinflammatory genes involved in atherosclerosis. | ||
| S4622 | 3,4-Diaminopyridine | 3,4-Diaminopyridine (Amifampridine, pyridine-3,4-diamine) blocks presynaptic potassium channels, and subsequently prolongs the action potential and increases presynaptic calcium concentrations. It is a drug predominantly used in the treatment of a number of rare muscle diseases. | ||
| S0123New | Roflumilast N-oxide | Roflumilast N-oxide is an inhibitor of PDE type 4. | ||
| S3107 | D-Pyroglutamic acid | D-Pyroglutamic acid (D-5-Oxoproline, D-Pyr-OH, 5-oxo-D-proline, (R)-5-Oxopyrrolidine-2-carboxylic acid) is an active endogenous metabolite that antagonizes the disruption of passive avoidance behaviour induced by the N-methyl-D-aspartate receptor antagonist AP-5. |
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| E0506 | Soybean oil | Soybean oil is a vegetable oil extracted from the seeds of the soybean (Glycine max). | ||
| S3752 | isoleucine | Isoleucine (Ile) is a non-polar, uncharged (at physiological pH), aliphatic amino acid that is used in the biosynthesis of proteins. | ||
| S9330 | 6-Hydroxy-4-methylcoumarin | 6-Hydroxy-4-methylcoumarin is a chemical. | ||
| S0572 | SMCC | SMCC (Succinimidyl-4-(N-maleimidomethyl cyclohexane)-1-carboxylate) is a hetero-bifunctional crosslinker that contain N-hydroxysuccinimide (NHS) ester and maleimide groups that allow covalent conjugation of amine- and sulfhydryl-containing molecules. SMCC-conjugated antigen couples spleen cells to induce antigen-specific immune responses. | ||
| S3109 | N-Acetyl-L-leucine | N-acetyl-L-leucine is an active endogenous metabolite that accelerates vestibular compensation after unilateral labyrinthectomy by action in the cerebellum and thalamus. |
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| E2904 | Poly(vinyl alcohol) | Poly(vinyl alcohol) is an artificial polymer that is used in many industries, such as textile, paper industry, and food packaging industry due to its high chemical and thermal stability. Poly(vinyl alcohol) is also an excellent source for fiber, polymer, textile, surface, organic. | ||
| S6314 | Bis(2-methyl-3-furyl)disulphide | Bis(2-Methyl-3-furyl) disulfide is a volatile sulfur compound that is a key contributor to the meat-like aroma in cooked meat. | ||
| S3111 | Pyridoxal hydrochloride | Pyridoxal hydrochloride (HQ) is an active endogenous metabolite. |
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| E0623New | HBC620 | HBC620 is an analogue of HBC which is a GFP fluorophore-like synthetic dye that is nonfluorescent in solution, but strongly fluoresces upon forming tight complex with Pepper RNA aptamer. HBC-Pepper complex can be used to visualize RNA dynamics in live cells. | ||
| E2530 | Isofebrifugin | Isofebrifugine is a natural quinazolinone alkaloid with antimalarial effect. |
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| S7407New | NFAT Inhibitor | NFAT Inhibitor (VIVIT peptide) is a selective inhibitor of nuclear factor of activated Tcells (NFAT) activation that effectively blocks calcineurin-mediated dephosphorylation of NFAT in cell extracts. It also serves as a valuable tool for the direct identification of NFAT target genes across various cell types. | ||
| S3754 | 4-Hydroxybenzoic acid | 4-Hydroxybenzoic acid (p-hydroxybenzoic acid, PHBA, para-Hydroxybenzoic acid, 4-hydroxybenzoate), also known as p-hydroxybenzoic acid (PHBA), is a phenolic derivative of benzoic acid and widely used in organic synthesis. It is the most widely distributed aromatic organic acid in the vegetable kingdom. | ||
| S5442 | DL-2-Aminoadipic acid | DL-2-Aminoadipic acid is an excitatory amino acid analogue, which functions as a glutamine synthetase inhibitor. | ||
| S5650 | Sodium Hyaluronate | Sodium hyaluronate is the sodium salt of hyaluronic acid, a glycosaminoglycan found in various connective tissue of humans. | ||
| S9056 | Tuberostemonine | Tuberostemonine, a natural product found in Stemona phyllantha and Stemona tuberosa, is an alkaloid and a metabolite. | ||
| S9336 | Ethyl Coumarin-3-carboxylate | Ethyl coumarin-3-carboxylate occupies an important position in the organic synthesis and is used in production of biologically active compounds. | ||
| S6321 | 2-Phenylpropionic acid | 2-Phenylpropionic acid (2-Phenylpropionate, Hydratropic acid, α-methyl-α-toluic acid) is an intermediate in alpha-Methylstyrene (2-phenylpropylene) metabolism. | ||
| E2898 | ε-poly-L-lysine HCl | ε-poly-L-lysine (ε-PL) is a naturally occurring poly(amino acid), which possesses excellent antimicrobial activity and has been widely used in food and pharmaceutical industries.This product is very susceptible to moisture, please keep it sealed! | ||
| S9337 | Ethyl vanillin acetate | Ethyl vanillin acetate is acectate form of ethyl vanillin, which is a flavorant and is used in the production of chocolate. | ||
| S6327 | trans-2-Methyl-2-pentenoic Acid | trans-2-Methyl-2-pentenoic Acid ((E)-2-Methyl-2-pentenoic Acid, strawberry acid) has a sweet berry-like aroma and flavor and is widely used in food flavor. | ||
| S6558 | Irosustat (BN83495) | Irosustat (STX64, BN83495), a tricyclic coumarin sulfamate, is an orally active, nonsteroid-based, irreversible steroid sulfatase inhibitor with an IC50 of 8 nM. | ||
| S3365 | (S)-(-)-1-Phenylethanol | (S)-(-)-1-Phenylethanol ((S)-1-Phenylethanol, (S)-(-)-Phenylethanol) is an enantiomer of 1-Phenylethanol with flavor properties. |
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| E0112 | INH154 | INH154 is a potent inhibitor of Nek2 and Hec1 binding. NH154 binds to Hec1, thus blocking Hec1 phosphorylation by NEK2, and kills cancer cells at the nanomolar range. | ||
| S3659 | Fludrocortisone acetate | Fludrocortisone (9α-fluorocortisol) is a synthetic pregnane steroid and a halogenated derivative of cortisol. It is used to treat adrenogenital syndrome, postural hypotension, and adrenal insufficiency. | ||
| S4872 | Titanium tetrafluoride | Titanium tetrafluoride is an inorganic compound that is an effective but instable caries preventive agent. | ||
| S9340 | Bz-RS-ISer(3-Ph)-Ome | Bz-RS-ISer(3-Ph)-Ome is a chemical. | ||
| S4993 | Timonacic | Timonacic (Thiazolidine-4-carboxylic acid, Detoxepa, Hepalidine, 1,3-Thiazolidine-4-carboxylic acid) is a cyclic sulfur amino acid derivative with potential antineoplastic and antioxidant activities. | ||
| S3213 | Veratryl alcohol | Veratryl alcohol (VA, Veratrole alcohol, 3,4-Dimethoxybenzyl alcohol), a secondary metabolite of some lignin degrading fungi, is the natural substrate of Lignin peroxidase (LiP). | ||
| S3366 | Monoethyl malonic acid | Monoethyl malonic acid (Ethyl hydrogen malonate, Monoethyl malonate, 3-Ethoxy-3-oxopropanoic acid) is the major urinary metabolites of ethyl 3-ethoxypropionate (EEP). |
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| E2903 | 2,4-dihydroxybenzaldehyde | 2,4-Dihydroxybenzaldehyde exhibits antimicrobial as well as antioxidant properties. | ||
| S1820 | Clofibrate | Clofibrate (Atromid-S), a fibric acid derivative used in the treatment of hyperlipoproteinemia type III and severe hypertriglyceridemia. | ||
| S4670 | Sucralfate | Sucralfate(Sucrose octasulfate-aluminum complex) is a sucrose sulfate-aluminium complex that binds to the ulcer, creating a physical barrier that protects the gastrointestinal tract from stomach acid and prevents the degradation of mucus. | ||
| S9047 | Leonurine Hydrochloride | Leonurine (SCM-198), a natural alkaloid extracted from Herba leonuri, is a promising anti-glycation agent with vasodilator, antioxidative, cardioprotective and neuroprotective effects. | ||
| S9343 | Sequoyitol | Sequoia alcohol (Sequoyitol) is isolated from Taxus natural organic compounds, it can be used to treat diabetes and other indications. | ||
| S6329 | 2-Oxobutanoic acid | 2-Oxobutanoic acid (2-Oxobutyrate, 2-ketobutyric acid, 2-oxobutyric acid, alpha-ketobutyric acid, α-ketobutyric acid) is a substance that is involved in the metabolism of many amino acids as well as propanoate metabolism and C-5 branched dibasic acid metabolism. | ||
| S6419 | Omilancor (BT-11) | Omilancor (BT-11) is an orally active lanthionine synthetase C-like 2 (LANCL2) binding compound for treating inflammatory bowel disease (IBD) (Kd value of 7.7 µM). | ||
| S0577 | 6-Maleimidohexanoic acid N-hydroxysuccinimide ester | 6-Maleimidohexanoic acid N-hydroxysuccinimide ester (EMCS) is a heterobifunctional cross-linking reagent. EMCS is used as a unique and useful reagent for preparation of hapten conjugate and enzyme immunoconjugates. | ||
| S3214 | Veratraldehyde (3,4-Dimethoxybenzaldehyde) | Veratraldehyde (3,4-dimethoxybenzaldehyde, VD, VAD, VAld, Verapamil Related Compound E, Methylvanillin), a derivative of vanillin, is the chemical that is found and isolated from peppermint, ginger, bourbon vanilla, and fruits such as raspberry. Veratraldehyde is widely used as a flavorant and odorant because of its pleasant woody fragrance. Veratraldehyde also acts as a redox cycle agent. | ||
| S3320 | (R)-3-Hydroxybutanoic acid | (R)-3-Hydroxybutanoic acid (R-3HB, D-3-hydroxybutyric acid) is a monomer of PHB (poly[(R)-3-hydroxybutyrate]) with wide industrial and medical applications. (R)-3-hydroxybutyric acid can also serve as chiral precursor for synthesis of pure biodegradable PHB and its copolyesters. |
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| E2910 | bisBenzimide H 33258 Trihydrochloride | bisBenzimide H 33258 Trihydrochloride(Hoechst 33258 trihydrochloride; H 33258 trihydrochloride) is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. It binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity. Therefore, Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution. It exhibits anti-tumor activity IC50 of 51.31±4.56 μM in HeLa cells. | ||
| S9345 | Disodium 5'-Inosinate | Disodium 5'-Inosinate, widely distributed in all animal and plant tissues, is used as a flavor enhancer. | ||
| S1062 | (S,R,S)-AHPC hydrochloride | (S,R,S)-AHPC hydrochloride (VH032-NH2, VHL ligand 1) is the VH032-based VHL ligand that is applicable to the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC hydrochloride can be connected to the ligand for protein by a linker to form PROTACs. | ||
| S3215 | 2-O-α-D-Glucopyranosyl-L-ascorbic acid | 2-O-α-D-Glucopyranosyl-l-ascorbic acid (AA-2G), which is a glucoside derivative of ascorbic acid (AA), shows vitamin C activity after enzymatic hydrolysis to ascorbic acid. The antitumor activity of AA-2G is caused by ROS generated by AA released by rapid hydrolysis of AA-2G. | ||
| S3049 | Calcium 2-hydroxy-4-(methylthio)butanoate | Calcium 2-hydroxy-4-(methylthio)butanoate is an active endogenous metabolite. |
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| S9347 | Allitol | Allitol (Allodulcitol) is a rare polyol found in nature that is useful not only as a sweetener, but also as the raw material for production of chemical compounds. | ||
| S6341 | 3-(Methylthio)propionic acid | 3-(Methylthio)propionic acid (3-methylthiopropionate, 4-Thiapentanoic acid, 3-Methylsulfanylpropionic acid) is a thia fatty acid acid consisting of propionic acid with a methylthio substituent at the 3-position and an intermediate in mammalian methionine metabolism in vitro. | ||
| S3135 | 2-Amino-1-phenylethanol | 2-Amino-1-phenylethanol (2-APE) is a noradrenaline analogue. |
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| E2905 | DIRECT RED 80 | Direct Red 80 (Sirius Red) is a polyazo dye used principally in staining methods for collagen and amyloid. Direct Red 80 does not release benzidine upon degradation and is safer than many traditional direct dyes. | ||
| S9348 | D-(+)-Trehalose Anhydrous | Trehalose is a non-reducing sugar. It is thought to provide plants and animals with the ability to withstanding periods of dehydration. | ||
| S6342 | Glycerol Tri-n-octanoate | Glycerol Tri-n-octanoate (Glycerol trioctanoate, Glycerol tricaprylate, Trioctanoin, Tricaprylin) is a well-known raw material largely used in cosmetic products. | ||
| S6061 | DL-m-Tyrosine | DL-m-Tyrosine is a potent, structurally unusual broad-spectrum phytotoxin exuded by the roots of some fine leaf fescue grasses. | ||
| S3221 | Thymidine 5'-monophosphate disodium salt | Thymidine-5'-monophosphate (5'-Thymidylic acid) disodium salt is an active endogenous metabolite. |
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| S4077 | Mequinol | Mequinol (4-Methoxyphenol) is a depigmentation agent. | ||
| S9049 | Parishin A | Parishin A, isolated from the rhizomes of Gastrodia elata, has good neuroprotective effects against brain disorders. | ||
| E2759 | L-(+)-Ergothioneine | L-(+)-Ergothioneine(Ergothioneine), an imidazole-2-thione derivative of histidine betaine, is synthesized by certain bacteria and fungi. Ergothioneine is generally considered an antioxidant. | ||
| S5027 | Mebeverine Hydrochloride | Mebeverine (Duspatalin, Duspatal, Colofac), a 3-phenylethylamine derivative of methoxybenzamine, acts as a musculotropic antispasmodic agent. | ||
| S9354 | Oxalic acid | Oxalic acid (Ethanedioic acid, Wood bleach) is a strong dicarboxylic acid occurring in many plants and vegetables. | ||
| S3321 | N-Methylnicotinamide | N-Methylnicotinamide (MNA, Nicotinyl Methylamide, N-Methyl-3-pyridinecarboxamide) is an active endogenous metabolite that improves endothelial dysfunction and attenuates atherogenesis via the modulation of ADMA-DDAH axis. |
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| E2895 | Sodium Bicarbonate | Sodium bicarbonate(Armex Blast Media Flow Formula XL, BI-CF 40E, BI-H 40E, Bakeshure 180, Sodium Hydrogen Carbonate, Sodium hydrogen carbonate) is a biochemical reagent used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions. | ||
| S3757 | 2'-Deoxyinosine | 2’-Deoxyinosine (Guanine deoxyriboside, Deoxyinosine) is the nucleoside form of hypoxanthine. It is a product of DNA damage that is formed from 2’-deoxyadenosine by adenosine deaminase or reactive nitrogen species. 2’-deoxyinosine enhances apoptosis induced by 5-fluorouracil in HT-29 and SW620 cancer cells. | ||
| S9358 | Scarlet 808 | Scarlet 808 is a chemical dyes. | ||
| S3325 | L-Cysteic acid monohydrate | L-Cysteic acid monohydrate (CAM) is an active endogenous metabolite. |
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| S5984 | AST5902 trimesylate | AST5902 is the principal metabolite of alflutinib both in vitro and in vivo, which exerts remarkable antineoplastic activity similar to alflutinib. AST5902 exhibits much weak CYP3A4 induction potential compared to alflutinib. | ||
| E2697 | TCPP | TCPP (Tris(2-chloroethyl) phosphate) is a pervasive flame retardant. | ||
| S6230 | Methyl 3-aminopyrazine-2-carboxylate | Methyl 3-aminopyrazine-2-carboxylate is used in chemical synthesis. | ||
| S3263 | Agarotetrol | Agarotetrol is a chromone derivative found in high concentrations in the water-extract fraction of agarwood. Agarotetrol contributes to the fragrance of agarwood through the generation of LACs upon heating. | ||
| S3329 | (L)-Dehydroascorbic acid | (L)-Dehydroascorbic acid (DHA) is an oxidized form of l-Ascorbic acid (AsA) that efficiently scavenges non-thermal plasma-induced hydroxyl radicals in the presence of thiols and fails to scavenge hydroxyl radicals by itself. |
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| S3561 | DLinDMA | DLinDMA (1,2-dilinoleyloxy-N,N-dimethyl-3-aminopropane) is a key component to facilitate endosomal escape through membrane fusion between the SNALP and the endosomal membranes. | ||
| E0376 | DPPE fumarate | DPPE fumarate (Tesmilifene fumarate) is a novel potentiator of chemotherapy, which is found to potentiate a wide range of cytotoxics and to protect normal cells. | ||
| E2959 | Streptavidin | Streptavidin is a crystalline protein isolated from the bacterium Streptomyces avidinii and possesses biotin-binding ability. The dissociation constant (Kd) of the biotin-streptavidin complex is about ~1015 M. Streptavidin has an immunosuppressive role. | ||
| S9058 | Gallocatechin gallate | Gallocatechin galleate (GCG) is a polyphenol originally derived from a variety of sources, including green tea, coffee, safflower, and almonds. | ||
| S9361 | Coumarin-3-carboxylic acid | Coumarin-3-carboxylic acid is used as a detector for hydroxyl radicals (.OH) in aqueous solution. | ||
| S5888 | Beclamide | Beclamide (N-Benzyl-3-chloropropionamide, beta-chlorpropionamide) exhibits sedative and anticonvulsant properties. | ||
| S6253 | H-D-Trp-OH | H-D-Trp-OH (D-Tryptophan) is the D-enantiomer of tryptophan, which is an essential amino acid in the human diet. | ||
| S3342 | Petroselinic acid | Petroselinic acid (PSA) is a positional isomer of oleic acid isolated from the vegetable oil of Coriandrum sativum fruits. Petroselinic acid can be used for the fermentation of new sophorolipids. |
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| E1183 | MRTX0902 | MRTX0902 is a potent SOS1 inhibitor for therapeutic intervention of KRAS-driven cancers with an IC50 of 46 nM. | ||
| S9059 | 4'-O-Glucosylvitexin | 4'-O-Glucosylvitexin is a kind of flavonoid fraction from the leaves of Crataegus pinnatifida. | ||
| S9362 | 1-Naphthaleneacetic acid | 1-Naphthaleneacetic acid (α-Naphthaleneacetic acid) is a synthetic plant hormone in the auxin family. | ||
| S3344 | Serotonin creatinine sulfate monohydrate | Serotonin (5-Hydroxytryptamine) creatinine sulfate monohydrate is an active endogenous metabolite. |
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| E0636 | GSK-1520489A | GSK-1520489A(EX-A5430) is an active Protein Kinase, Membrane Associated Tyrosine/Threonine 1 (PKMYT1) inhibitor. | ||
| E2698 | Tris(2-ethylhexyl) phosphate | Tris (2-ethylhexyl) phosphate, a clear, viscous liquid, is used as a component of vinyl stabilizers, grease additives, and flame-proofing compositions; however, it is used primarily as a plasticizer for vinyl plastic and synthetic rubber compounds. | ||
| S4264 | Etofibrate | Etofibrate is a combination of clofibrate and niacin, used to treat hyperlipemia. | ||
| S3686 | Thioisonicotinamide | Thioisonicotinamide (Pyridine-4-carbothioamide, Isothionicotinamide, 4-Pyridylthiocarboxamide) is a synthetic intermediate used for pharmaceutical synthesis. | ||
| S9060 | Nystose | Nystose (1,1-Kestotetraose, Fungitetraose), a constituent of seeds of onions and roots of Asparagus, is a low-calorie sweetening agent for food and chewing gum. | ||
| S9364 | 6-Hydroxycoumarin | 6-Hydroxycoumarin demonstrates cytotoxic effect against the cancer cell lines. | ||
| S6310 | N-(2-Acetamido)-2-Iminodiacetic acid | N-(2-Acetamido)-2-Iminodiacetic acid (ADA buffer) is a biological buffer component and can be used as a pharmaceutical intermediate. | ||
| S4265 | Nicaraven | Nicaraven is a hydroxyl radical scavenger with antivasospastic and neuroprotective effects. | ||
| S3772 | 5-Hydroxymethylfurfural | 5-Hydroxymethylfurfural (5-HMF) is an important bio-sourced intermediate, formed from carbohydrates such as glucose or fructose and used for production of fuels and chemical intermediates. | ||
| S5443 | BSTFA-TMCS | BSTFA-TMCS is used as a derivatizing agent in chromatography. It functions as a silylation reagent without additional solvents. The combination of BSTFA and TMCS is the preferred reagent for trimethylsilylation of alcohols, alkaloids, amines, biogenic amines, carboxylic acids, phenols, and steroids. | ||
| S9365 | Disodium uridine-5'-monophosphate | Disodium uridine-5'-monophosphate is a nucleotide that is a major component of ribonucleic acid. | ||
| S6006 | Imidazole | Imidazole (1,3-diazole, glyoxaline, 1,3-diazacyclopenta-2,4-diene) is a heterocyclic aromatic organic compound. It can be incorporated into many important biological molecules and acts as a corrosion inhibitor for industrial applications. | ||
| S6312 | L-Threonic acid Calcium Salt | L-Threonic acid Calcium Salt (Calcium threonate) is a calcium salt of threnoic acid. L-Threonic acid is a metabolite of ascorbic acid (vitamin C). | ||
| S3349 | Phosphocholine chloride calcium salt tetrahydrate | Phosphocholine (Phosphorylcholine) chloride calcium salt tetrahydrate is an active endogenous metabolite. |
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| E0305 | UNC 3230 | UNC3230 is a potent, selective and ATP-competitive PIP5K1C inhibitor with an IC50 of ~41 nM and also inhibits PIP4K2C . It also has antinociceptive and anticancer effects. | ||
| E1795New | Triparanol(MER-29) | Triparanol (MER-29) is an inhibitor of 24-dehydrocholesterol reductase (DHCR24), an enzyme involved in cholesterol biosynthesis. It exhibits antitumor properties, such as decreasing proliferation and inducing apoptosis in various cancer cell lines, while also reducing Hedgehog pathway signaling in these cells. | ||
| E4778New | BODIPY 493/503 | BODIPY 493/503 (Pyrromethene 546, BDP 493/503 lipid stain) is a fluorescent neutral lipophilic dye. It is used to facilitate quantification of neutral lipid content, a lipid droplet–associated protein by flow cytometry and observation of lipid droplets(LDs) by microscopy. | ||
| S3693 | 2,6-Dihydroxypurine | 2,6-Dihydroxypurine (Xanthine, Isoxanthine) is a purine base found in most body tissues and fluids, certain plants, and some urinary calculi. It is a product on the pathway of purine degradation. | ||
| S9062 | 4-Hydroxyisoleucine | 4-Hydroxyisoleucine, an atypical branched-chain amino acid derived from fenugreek, has effects on the glucose and lipid metabolism, stimulates glucose-dependent insulin secretion and reduces insulin resistance in muscle and/or liver. | ||
| S6007 | Bisphenol A | Bisphenol A is a starting material for the synthesis of plastics, primarily certain polycarbonates and epoxy resins, as well as some polysulfones and certain niche materials. It exhibits estrogen-mimicking, hormone-like properties. | ||
| E2922 | Formamide | Formamide (Methanamide; Formimidic acid) is a clear liquid amide derived from formic acid. It allows for the denaturation and renaturation of nucleic acids at room temperature. Formamide-induced DNA denaturation when combined with detection of denatured DNA with a monoclonal antibody (MAb) makes it possible to specifically identify the apoptotic cells. | ||
| E4657New | PFI-6 | PFI-6 is a selective MLLT1/3 probe that targets the YEATS domain of MLLT1 (ENL/YEATS1) and MLLT3 (AF9/YEATS3) with IC50 values of 140 nM and 160 nM for MLLT1 and MLLT3, respectively. PFI-6 demonstrates increased affinity and selectivity for MLLT1/3 than other human YEATS domain proteins (YEATS2/4). | ||
| S4976 | Sulfalene (SMPZ) | Sulfalene (SMPZ, Butadiene sulfone, 3-Sulfolene) is a cyclic organic chemical used as a versatile synthetic intermediate. | ||
| S5705 | Raceanisodamine | Raceanisodamine (7β-Hydroxyhyoscyamine) is the active ingredient of Chinese herbal extracts that has vasoactive activity used to treat acute disseminated intravascular coagulation in patients in bacteremic shock. | ||
| S9367 | Adenosine disodium triphosphate hydrate | Adenosine disodium triphosphate hydrate (ATP disodium) is the sodium salt form of adenosine triphosphate (ATP), a complex organic chemical that provides energy to drive many processes in living cells. | ||
| S3352 | Tricosanoic acid | Tricosanoic acid is an aliphatic carboxylic acid that exhibits a strong hair-growing effect. |
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| E2523 | STK414603 | STK414603 is a heterocyclic acetamide derivative with potential in vivo analgesic, anti-inflammatory, and in vitro antimicrobial activities | ||
| E2913 | Fast Green FCF | Fast Green FCF (FD&C Green No. 3; Food green 3; C.I. 42053) is a sea green triarylmethane food dye. It is a dye used to stain proteins for IEF (isoelectric focusing) and SDS-PAGE. When bound to proteins, Fast Green FCF fluoresces near infrared (absorption maximum: 624 nm). Fast Green FCF staining is linear over a wider range of protein concentrations compared to Brilliant Blue R. | ||
| S6010 | Sodium L-lactate | Sodium L-lactate is used as a food additive, preservative, acidity regulator and bulking agent. | ||
| S3353 | Lithium acetoacetate | Lithium acetoacetate (LiAcAc, Acetoacetic acid lithium salt, Lithium 3-oxobutanoate) is an active endogenous metabolite that affects the growth of cells. Lithium acetoacetate can be used as an acetoacetate standard for the measurement of acetoacetate in biological samples. | ||
| E4074 | p-Toluic acid | p-Toluic acid (4-Methylbenzoic acid) is a methylbenzoic acid and can be used as an intermediate for the synthesis of para-aminomethylbenzoic acid (PAMBA), p-tolunitrile, etc. It also exhibits hepatotoxicological potential in humanised-liver mice. | ||
| S9369 | Xanthosine | Xanthosine (Xanthine riboside) is an intermediate in purine metabolism, formed from IMP, and forming GMP. | ||
| S6403 | Chloramine-T | Chloramine-T is a N-chlorinated and N-deprotonated sulfonamide used as a biocide and a mild disinfectant. | ||
| S3354 | DL-2,3-Diaminopropionic acid monohydrochloride | DL-2,3-Diaminopropionic acid monohydrochloride (2,3-Diaminopropanoic acid hydrochloride) is an active endogenous metabolite. |
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| S9066 | Specnuezhenide | Specnuezhenide (Nuezhenide), one of the main ingredients of Chinese medicine, has anti-angiogenic and vision improvement effects. | ||
| S9370 | Adenosine Cyclophosphate | Adenosine Cyclophosphate (Cyclic adenosine monophosphate, cAMP, cyclic AMP, 3',5'-cyclic adenosine monophosphate) is useful for improving myocardial hypoxia, dilating coronary artery and strengthening myocardiac contraction. | ||
| S2021 | Chlormezanone | Chlormezanone，a non-benzodiazepine that is used in the management of anxiety. It has been suggested for use in the treatment of muscle spasm. | ||
| S6014 | Isonicotinic acid | Isonicotinic acid (Isoniazid, 4-pyridinecarboxylic acid, p-pyridinecarboxylic acid, 4-Picolinic acid) is a metabolite of isoniazid. It is an isomer of nicotinic acid. | ||
| S6405 | Octisalate | Octisalate (Ethylhexyl Salicylate, Octyl salicylate) is an organic compound used as an ingredient in sunscreens and cosmetics to absorb UVB (ultraviolet) rays from the sun. | ||
| S3683 | Methylmalonate | Methylmalonate (Methylmalonic acid, Isosuccinic Acid, NSC 25201, MMA) is a dicarboxylic acid that can be derived from methylmalonyl-coenzyme A (methylmalonyl-CoA). | ||
| S6015 | Benzylcetyldimethylammonium chloride hydrate | Benzylcetyldimethylammonium chloride hydrate is a chemical. | ||
| E2915 | Ovalbumin (257-264) | Ovalbumin (257-264) is a class I (Kb)-restricted peptide epitope of ovalbumin (OVA) and has been used to trigger T cell activation in immunology studies. | ||
| E1628New | BMS-911172 | BMS-911172 is a brain penetrant, selective inhibitor of adaptor protein 2-associated kinase 1 (AAK1) with an IC50 value of 12 nM. BMS-911172 inhibits μ2 phosphorylation and has potential as a therapeutic agent in neuropathic pain research. | ||
| S3936 | 7-Hydroxycarbostyril | 7-Hydroxycarbostyril (3,4-Dihydro-7-hydroxycarbostyril) is a kind of pharmaceutical intermediate. | ||
| S4982 | 2,2':5',2''-Terthiophene | 2,2':5',2''-Terthiophene is a natural product occurring in marigold which shows UV-enhanced antibiotic activity. | ||
| S6018 | 2,3,4-Trihydroxybenzoic acid | 2,3,4-Trihydroxybenzoic acid is a phenol constituent of Pachysandra terminalis with antioxidant activity. | ||
| S3359 | Isomaltulose hydrate | Isomaltulose (Palatinose) hydrate is a disaccharide carbohydrate widely used during exercise to maintain glycaemia and hydration. |
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| E0082 | R59949 | R59949, a diacylglycerol kinase (DGK) inhibitor with an IC50 of 300 nM, inhibits inducible nitric oxide production through decreasing transplasmalemmal L-arginine uptake in vascular smooth muscle cells. R59949 strongly inhibits type I DGK a and γ, and moderately attenuates type II DGK θ and κ. | ||
| S9044 | Ginsenoside F2 | Ginsenoside F2, a ginsenoside found in Panax species, is an autophagic initiater with anti-cancer, and anti-obesity activities. | ||
| S3361 | (3-Carboxypropyl)trimethylammonium chloride | (3-Carboxypropyl)trimethylammonium chloride (γ-Butyrobetaine, γBB hydrochloride) is an intermediary metabolite by gut microbes from dietary L-carnitine in mice. |
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| E2686 | Methoprene | Methoprene is a growth-regulating insecticide that manifests its toxicity to target organisms by acting as a juvenile hormone agonist. | ||
| E6015New | Heparin (Lithium salt) | Heparin Lithium salt is an anticoagulant that binds reversibly to antithrombin III (ATIII). Heparin Lithium salt is used as an anticoagulant for laboratory studies and in direct membrane-feeding assays. | ||
| S6020 | Potassium thioacetate | Potassium thioacetate is widely used as a sulfur source in the synthesis of sulfur-containing organic compounds. It has been employed for the synthesis of heterocycles, polymers, transition-metal ligands, nanoparticles, bioactive compounds and macromolecular inclusion complexes. | ||
| S0150 | ML239 | ML239 is a potent and selective inhibitor of breast cancer stem cells, with an IC50 of 1.16 μM, with ~24-fold selectivity against the control cell line. | ||
| S3362 | D-Gulonic acid γ-lactone | D-Gulonic acid γ-lactone (Gulonolactone, D-Gulono-1,4-lactone, 1,4-D-Gulonolactone) is an active endogenous metabolite. | ||
| E2920 | 3-Aminopropyltriethoxysilane | 3-Aminopropyltriethoxysilane (γ-Aminopropyltriethoxysilane) is an aminosilane commonly used for biomolecule immobilization on silicon and silicon derivatives such as silicon nitride (Si3N4). | ||
| S2317 | L-(+)-Rhamnose Monohydrate | L(+)-Rhamnose (Rham) is a naturally-occurring deoxy sugar that is found primarily in plants and some bacteria. | ||
| S9030 | Tenacissoside I | Tenacissoside I is a natural compound found in M. tenacissima at relatively high level. | ||
| S9073 | Lithospermoside | Lithospermoside (Griffonin), extracted from the roots of Lithospermum purpurocaeruleum and L.officinale (Borginaceae), and Thalictrum rugosum and T. dasycarpum (Ranunculaceae), has anti-oxidant, anti-tumor promoting activities. | ||
| S6022 | Cyclohexaneacetic acid | Cyclohexaneacetic acid is a flavouring ingredient. | ||
| E2918 | Sesame Oil | Sesame oil is a supplement that has anti-inflammatory and antioxidant properties, which make it effective for reducing atherosclerosis and the risk of cardiovascular disease. | ||
| P1243New | Fetuin, Fetal Bovine Serum | Fetuin, Fetal Bovine Serum, a prevalent protein found in fetal bovine plasma, is the bovine equivalent of human α2HS glycoprotein (α2HS), commonly used as a supplement in various serum-free media. It inhibits trypsin activity and enhances cellular attachment, growth, and differentiation in culture systems. | ||
| S3762 | Methylnonylketone | Methylnonylketone (2-Undecanone, IBI-246), also known as 2-Undecanone and IBI-246, is a natural non-toxic insect repellant compound. | ||
| S5029 | Etofylline | Etofylline (Aethophyllinum, Cordalin, Oxyphylline) is a N-7 substituted theophylline derivative used as a bronchodilator. | ||
| S5653 | Indigo carmine | Indigo carmine (Indigotine, 5,5′-indigodisulfonic acid sodium salt, Brilliant Indigo) is an indicator at pH 11.5-14, changing from blue to yellow. It has a role as a food colouring and a histological dye. | ||
| S9389 | Phorbol | Phorbol is a natural, plant-derived organic compound that exerts a broad range of biological activities. | ||
| S6025 | 3-Methoxybenzoic acid | 3-Methoxybenzoic acid (m-Anisic acid, 3-Methoxybenzoate, 3-Anisic acid, m-Methylsalicylic acid) is a food additive that acts as a flavouring ingredient. | ||
| S6406 | Ferrous fumarate | Ferrous fumarate (Iron(II)) is the fumarate salt form of the mineral iron and is used in treatment of iron deficiency anemia. | ||
| S3367 | cis-4-Hydroxy-D-proline | cis-4-Hydroxy-D-proline (H-D-cis-Hyp-OH) is an endogenous metabolite that can be used to study the specificity and kinetics of D-alanine dehydrogenase. |
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| S3789 | Tiglic acid | Tiglic acid (Cevadic acid, Sabadillic acid, Tiglinic acid) is a monocarboxylic unsaturated organic acid found in croton oil and in several other natural products. It is used in making perfumes and flavoring agents. | ||
| S9401 | 3,6'-Disinapoyl sucrose | 3,6'-Disinapoyl sucrose (Disinapoyl sucrose), an oligosaccharide ester natural product originating from the root of wild Polygala tenuifolia, has neuroprotective effects and antidepressive activity in rats. | ||
| S6027 | D-(−)-Pantolactone | D-(−)-Pantolactone is the degradation product of pantothenic acid, which is a water-soluble essential vitamin. | ||
| S5160 | 4-Methoxysalicylic acid | 4-Methoxysalicylic acid (2-Hydroxy-p-anisic Acid), an arabinose derivative, is used in the synthesis of 1,3,4-oxadiazole derivatives. | ||
| S5717 | Acetohexamide | Acetohexamide is an intermediate-acting, first-generation oral sulfonylurea with hypoglycemic activity. It exerts the blood-glucose-lowering effects by stimulating the pancreatic beta cells to secrete insulin and by helping the body use insulin efficiently. | ||
| S9076 | Typhaneoside | Typhaneoside is a flavonoid glycoside plant extract that has an inhibitory effect on the proliferation of human umbilical arterial smooth muscle cell(HUASMC). | ||
| S5835 | 3-(4-Hydroxyphenyl)-1-propanol | 3-(4-Hydroxyphenyl)-1-propanol is a reagent in the synthesis of (−)-Centrolobine, which is an anti-Leishmania agent. | ||
| S6048 | 3-Oxopentanedioic acid | 3-Oxopentanedioic acid (1,3-Acetonedicarboxylic acid; 3-Oxoglutaric acid) is an intermediate for organic compound synthesis. | ||
| S3371 | N-Acetyl-D-mannosamine | N-Acetyl-D-mannosamine (ManNAc, N-acetyl-beta-mannosamine), a precursor of a sialic acid, improves the age-dependent attenuation of synaptic transmission and long-term potentiation (LTP). N-Acetyl-D-mannosamine treatment is a potential therapeutic application for cognitive dysfunction. |
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| E4637New | PK 11195 | PK 11195 (RP 52028) is a translocator protein (TSPO) ligand, a potent and selective antagonist of peripheral benzodiazepine receptorwith high affinity Ki of 3.1 nM in cerebellum and 4.1 nM in spinal cord. It is also an antagonist of human constitutive androstane receptor (hCAR), and human pregnane X receptor (PXR). It displaces [3H] RO5-4864 from its binding sites across organs and also targets Leishmania in chemotherapy. | ||
| S3791 | Succinic acid | Succinic acid (1,4-Butandioic Acid, 1,2-Ethanedicarboxylic acid, Amber acid, Asuccin, Butanedioic acid) is a crystalline organic acid which occurs in living tissue as an intermediate in glucose metabolism. | ||
| S9398 | Crassicauline A | Crassicauline A, a diterpenoid alkaloid in Aconitum herbs, is an analgesic drug clinically used in China. | ||
| S6028 | α-D-Glucose anhydrous | Alpha-D-Glucose is a primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is an intermediate in glycolysis/gluconeogenesis pathway. | ||
| E1256 | Ibotenic acid | Ibotenic acid((RS)-Ibotenic acid; DL-Ibotenic acid) is a neuroexcitatory amino acid originally isolated from Amanita species. It exhibits agonist activity at both N-methyl-D-aspartate (NMDA) and trans-ACPD) or metabolotropic quisqualate (Qm) receptor sites. | ||
| S4204 | Isosorbide | Isosorbide(D-Isosorbide,Dianhydro-D-glucitol) is a heterocyclic compound that is derived from glucose, used as a diuretic. | ||
| S5163 | 7-Methoxycoumarin | 7-Methoxycoumarin (Herniarine), also known as Herniarin, is a methoxy derivative of coumarin and substrate for dealkylase. It has been used in the synthesis of anti-first-pass effect compounds and detergents. | ||
| S9397 | Alliin | Alliin (S-allyl cysteine sulfoxide, ACSO, 3-(Allylsulphinyl)-L-alanine) is a sulfoxide that is a natural constituent of fresh garlic. | ||
| S5820 | L-Hydroxyproline | L-Hydroxyproline (trans-4-Hydroxy-L-proline) is a collagen-specific amino acid. It is used as a diagnostic marker of bone turnover and liver fibrosis. | ||
| S6030 | 3-(3-Methoxyphenyl)propionic acid | 3-(3-Methoxyphenyl)propionic acid is a naturally occurring human metabolite, It is an organic acid and excreted in human urine. | ||
| E1185 | SR-0813 | SR-0813 is a potent and selective ENL/AF9 YEATS domain inhibitor. SR-0813 has IC50 values of 25 and 311 nM for ENL YEATS domain and AF9 YEATS domain, respectively. | ||
| S2124 | Xylose | Xylose(Wood sugar) is a sugar first isolated from wood. | ||
| S4205 | Dibenzothiophene | Dibenzothiophene (DBT,Diphenylene sulfide) is a model compound for organic sulfur in fossil fuels. | ||
| S4316 | Clopamide | Clopamide is categorised as a thiazide-like diuretic and works in similar way as the thiazide diuretics do. | ||
| S5165 | Solvent Red 23 | Solvent Red 23 (Cerasin Red, Sudan III, Sudan Red III, Fettscharlach) is a solvent dye used to color nonpolar substances such as oils, fats, waxes, greases, various hydrocarbon products, and acrylic emulsions. | ||
| S9079 | Ginsenoside Rb2 | Ginsenoside Rb2 (Ginsenoside C) is a ginsenoside found in Panax ginseng that has a role as a plant metabolite, an antiviral agent and a hypoglycemic agent. | ||
| S5833 | Methyl Nonadecanoate | Methyl nonadecanoate (Nonadecanoic Acid methyl ester) is a fatty acid methyl ester, which is less water soluble but more amenable for the formulation of nonadecanoate-containing diets and dietary supplements. | ||
| S3322 | Nicotinuric acid | Nicotinuric acid (NUA) is the major detoxification product of nicotinic acid and may serve as a simple quantitative index of hepatic biotransformation of nicotinic acid. |
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| E1175 | RP-6306 | RP-6306 is a Protein Kinase, Membrane Associated Tyrosine/Threonine 1 (PKMYT1) inhibitor, which can be used for the research of cancer. | ||
| S5826 | Monobutyl phthalate | Monobutyl phtalate is a metabolite of di(n-butyl)phthalate. It affects the expressions of EMT-related proteins and enhances the migration and invasion of MLTC-1 cells. | ||
| S6032 | 2-Aminobenzenesulfonic acid | 2-Aminobenzenesulfonic acid (Orthanilic acid, O-Aminobenzenesulfonic acid, Aniline-2-sulfonic acid) is a biological acid with roles in benzoate degradation and microbial metabolism in diverse environments. | ||
| S3332 | D-Mannosamine hydrochloride | D-Mannosamine hydrochloride ((2S,3R,4S,5R)-2-Amino-3,4,5,6-tetrahydroxyhexanal hydrochloride) is an active endogenous metabolite. |
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| E6006New | Deferasirox (Fe3+ chelate) | Deferasirox (Fe3+ chelate) (Exjade) is an oral tridentate iron chelator used for reducing transfusional chronic iron overload. It exhibits efficacy in iron-overloaded patients with anemias, thalassemia, sickle cell disease and myelodysplastic syndromes. It is also an orally effective antitumor agent against solid tumors. | ||
| S9393 | (4S)-4-Hydroxy-L-isoleucine | (4S)-4-hydroxy-L-isoleucine is an L-isoleucine derivative that is L-isoleucine bearing a (4S)-hydroxy substituent. It has a role as a plant metabolite. | ||
| S6033 | Azo Rubine | Azo Rubine is an synthetic red food dye and is used for the purposes where food is heat-treated after fermentation. | ||
| S6430 | Nervonic acid | Nervonic acid (cis-15-Tetracosenoic acid) is a long chain unsaturated fatty acid that is enriched in sphingomyelin and may enhance the brain functions and prevent demyelination. | ||
| S0159 | Pirozadil | Pirozadil is a hypolipidemic agent. | ||
| E2923 | Bile Extract Porcine | Bile extract porcine (Ox bile extract) is used as a supplement in brain heart infusion (BHI) medium to culture Listeria monocytogenes LO28. It is also used to investigate the survival of probiotic bacteria through the gastric-small intestine. | ||
| S4208 | Chromocarb | Chromocarb(Atremon) is a vasoprotectant. | ||
| S3949 | N-Sulfo-glucosamine sodium salt | N-Sulfo-glucosamine sodium salt (N-sulfoglucosamine sodium salt) is a member of the class of compounds known as hexoses that is soluble (in water) and an extremely strong acidic compound. It locates in the cytoplasm within the cells. | ||
| S9082 | Manninotriose | Manninotriose, found in many foods, is a novel and important player in the RFO metabolism of red dead deadnettle. | ||
| S3040 | Isocitric acid trisodium salt | Isocitric acid (DL-Isocitric acid) trisodium salt is an active endogenous metabolite. |
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| E0705 | Flavin Adenine Dinucleotide Disodium | Flavin Adenine Dinucleotide Disodium is a redox cofactor, more specifically a prosthetic group of a protein, involved in several important enzymatic reactions in metabolism. | ||
| E1221 | CIA1 | CIA 1 (COUP-TFII inhibitor A1) is a specific inhibitor of the nuclear receptor COUP-TFII with IC50 of 1.2 μM to 7.6 μM in prostate cancer cell lines. | ||
| S3797 | Helicide | Helicide (4-formylphenyl-O-β-d-allopyranoside), a main active constituent from seeds of the Chinese herb Helicia nilagirica, has been reported to exert a sedative, analgesic and hypnotic effect, and is used clinically to treat neurasthenic syndrome, vascular headaches and trigeminal neuralgia. | ||
| S3950 | Maltitol | Maltitol (Maltisorb, 4-O-α-glucopyranosyl-D-sorbitol) is a sugar alcohol (polyol) used as a sugar substitute. It is especially useful in the production of sweets, including sugarless hard candies, chewing gum, chocolates. | ||
| S8756 | XRK3F2 | XRK3F2 is an inhibitor of the p62-ZZ domain that blunts MM-induced Runx2 suppression in vitro, and induces new bone formation and remodeling in the presence of tumor in vivo. | ||
| S6035 | 2-Naphthol | 2-Naphthol (2-Hydroxynaphthalene, 2-Naphthalenol, beta-Naphthol, Naphth-2-ol, β-naphthol), a potential antinematodal drug, is a widely used intermediate for the production of dyes and other compounds. | ||
| S3089 | 12-Hydroxydodecanoic acid | 12-Hydroxydodecanoic acid (G12) is an active endogenous metabolite. |
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| E4092 | Ricinoleic acid | Ricinoleic acid is a hydroxy fatty acid. It is an attractive feedstock for the production of high-performance lubricants, cosmetics, polymers, surfactants, and coatings. | ||
| S2609 | Inulin | Inulin(Inulin and sodium chloride), a starch found in the tubers and roots of many plants. Since it is hydrolyzable to fructose, it is classified as a fructosan. | ||
| S3798 | L-Citrulline | L-citrulline is a substance called a non-essential amino acid that is used as a sports performance and cardiovascular health supplement. | ||
| S5831 | Furfuryl acetate | Furfuryl acetate (Furan-2-ylmethyl, 2-Furanmethanol, 2-Acetoxymethylfuran) is widely used as a flavoring agent in food and bakery. | ||
| S6042 | Trimethylamine N-oxide dihydrate | Trimethylamine N-oxide dihydrate, a product of the oxidation of trimethylamine, is considered as a protein stabilizer that may serve to counteract urea, the major osmolyte of sharks, skates and rays. | ||
| E4732New | FDW028 | FDW028 is a highly potent and selective inhibitor of FUT8. FDW028 demonstrates strong anti-tumor effects by promoting defucosylation and inducing lysosomal degradation of B7-H3 via the chaperone-mediated autophagy (CMA) pathway. Additionally, FDW028 suppresses the AKT/mTOR signaling pathway. FDW028 exhibits potent anti-Metastatic colorectal cancer (mCRC) activities. | ||
| S5030 | Dihydralazine sulphate | Dihydralazine sulphate (Nepresol, Depressan, 1,4-Dihydrazinophthalazine, Hydralazine) is a dihydralazine-l,4-phthalazine derivative and used as an antihypertensive drug. | ||
| S9403 | Ecliptasaponin A | Ecliptasaponin A, a natural triterpenoid glucoside, has protective effects against the pulmonary fibrosis induced by bleomycin via reducing the oxidative stress, lung tissue inflammation, and the subsequent epithelial-mesenchymal transition. | ||
| S5821 | Linoleic acid | Linoleic acid (9,12-octadecadienoic acid) is an essential fatty acid used in the biosynthesis of arachidonic acid and found in the lipids of cell membranes. | ||
| S6043 | 3-Indoleacetonitrile | 3-Indoleacetonitrile, a plant growth hormone, is a light-induced auxin-inhibitory substance that is isolated from light-grown cabbage (Brassica olearea L.) shoots. | ||
| E2925 | 2,2-Diphenyl-1-picrylhydrazyl | 2,2-Diphenyl-1-picrylhydrazyl (DPPH) is a stable free radical that can be used to measure the radical scavenging activity of antioxidants. The odd electron of nitrogen atom in DPPH is reduced by receiving a hydrogen atom from antioxidants to the corresponding hydrazine. | ||
| S5106 | Lanolin | Lanolin (wool wax, wool grease) is a wax secreted by the sebaceous glands of wool-bearing animals and used widely in the pharmaceutical and cosmetics industries. | ||
| S6045 | L-Arabinitol | L-Arabinitol is a member of the class of compounds known as sugar alcohols that exists in all living species, ranging from bacteria to humans. It can be found in a number of food items such as sweet potato, deerberry, moth bean, and European chestnut, which makes L-arabitol a potential biomarker for the consumption of these food products. | ||
| E2649 | Afatinib impurity 11 | Afatinib impurity 11 is an impurity of afatinib, an EGFR family inhibitor. | ||
| E1896New | BMS-502 | BMS-502 is a potent dual inhibitor of diacylglycerol kinase (DGK) α and ζ with IC50 values of 4.6 nM and 2.1 nM, respectively. BMS-502 also exhibits an EC50 value of 340 nM in the mouse cytotoxic T cell IFN-γ assay (mCTC). BMS-502 can be used in tumor immunity-related research. | ||
| S3873 | Methyl 4-hydroxycinnamate | Methyl 4-hydroxycinnamate (OMpCA) is a model chromophore of the Photoactive Yellow Protein (PYP). | ||
| S6046 | (S)-Leucic acid | Leucic acid ((S)-α-hydroxyisocaproic acid) is a metabolite of the branched chain amino acid known as leucine, which plays a significant role in the synthesis of muscle protein. | ||
| S3248 | 2'-Deoxyadenosine 5'-monophosphate | 2'-Deoxyadenosine 5'-monophosphate (5'-dAMP), an endogenous metabolite, is only photosensitized degraded under acidic conditions. |
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| S6047 | Lactose | Lactose is a disaccharide naturally found in milk and dairy. | ||
| S3268 | 2'-Deoxycytidine 5'-monophosphate | 2'-Deoxycytidine-5'-monophosphoric acid (dCMP) is an endogenous metabolite that can be used as a model to describe mechanisms of DNA-strand breaks induced by secondary electrons and decomposes primarily by dissociation of the C-O phosphoester bond. |
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| S5962 | DL-Penicillamine | DL-Penicillamine (DL-beta-Mercaptovaline, 3,3-Dimethyl-DL-cysteine, 3-Sulfanylvaline, Cuprimine, Depen, DL-PenA, DL-P) induces alteration of elastic fibers of periosteum-perichondrium and associates growth inhibition. | ||
| S6050 | 1,3-Dimethyluracil | 1,3-Dimethyluracil (N,N'-dimethyluracil) is a methyl derivative of uric acid, found occasionally in human urine. | ||
| S3318 | N-Acetyl-L-arginine dihydrate | N-Acetyl-L-arginine (Ac-Arg-OH) dihydrate is an endogenous metabolite. |
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| E2934 | Methyl cellulose (Viscosity:100000mPa.s) | Methyl cellulose ( hydroxypropyl methylcellulose, hypromellose) viscosity: 100000 mPa.s., a soluble methylcellulose ether, is used as a thickening agent, binder, film former, and hydrophilic matrix material. | ||
| S4327 | Famprofazone | Famprofazone (Geodowin, FA, Famprofazonum) is a non-steroidal anti-inflammatory agent (NSAID) of the pyrazolone series. Famprofazone is an analgesic used for fever and pain relief. | ||
| S4867 | Propacetamol hydrochloride | Propacetamol hydrochloride (PRO) is a water-soluble prodrug of paracetamol (PA) which can be parenterally administered as analgesic for the treatment of postoperative pain, acute trauma, and gastric and/or intestinal disorders. | ||
| S5832 | Pyrrole-2-carboxylic acid | Pyrrole-2-carboxylic acid (2-Pyrrolecarboxylic acid) is a degradation product of sialic acids and a derivative of the oxidation of the D-hydroxyproline isomers by mammalian D-amino acid oxidase. | ||
| S6051 | Phenyl-ac-Gly-OH | Phenyl-ac-Gly-OH (N-(2-Phenylacetyl)glycine, 2-Phenylacetyl glycine, Phenaceturic acid, Phenacetylglycine) is one of acyl glycines that are normally minor metabolites of fatty acids. | ||
| S3319 | Levoglucosan | Levoglucosan (LG, LEV, Leucoglucosan, Glucosan, 1,6-anhydro-b-D-Glucose) is an endogenous metabolite. |
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| E2932 | SI-2 Hydrochloride | SI-2 hydrochloride (EPH 116 hydrochloride) is an inhibitor of Steroid receptor coactivator 3 (SRC-3), with IC50 of 3–20 nM, it can significantly inhibit breast tumor growth. | ||
| S5928 | Zerumbone | Zerumbone, derived from several plant species of the Zingiberaceae family, is a naturally occurring dietary compound and may have multiple biomedical properties, such as antiproliferative, antioxidant, anti-inflammatory, and anticancer activities. | ||
| S6052 | Saccharin sodium salt hydrate | Saccharin (O-Sulfobenzimide, O-Benzoic sulfimide, Saccharimide) is an artificial sweetener with effectively no food energy. | ||
| S3324 | Sodium 2-(1H-indol-3-yl)acetate | Sodium 2-(1H-indol-3-yl)acetate (3-Indoleacetic acid sodium, Indole-3-acetic acid sodium, 3-IAA sodium) is an endogenous metabolite. |
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| S9873 | 5-Fluoroorotic acid | 5-Fluoroorotic acid (5-FOA, 5-Fluoroorotate, NSC 31712) is a selective agent in yeast molecular genetics. 5-Fluoroorotic acid possesses a well-expressed anticandidal effect close to that of 5-fluorocytosine, as well as moderate antidermatophytal effects. | ||
| E4356 | Pseudotropine | Pseudotropine(3β-Tropanol, ψ-Tropine) is an alkaloid and a plant metabolite of the tropane tropinone that has been found in A. belladonna. It is used in the preparation of novel nicotinic receptor agonists. | ||
| S4985 | Dimethyl 4-Hydroxyisophthalate | Dimethyl 4-Hydroxyisophthalate (4-Hydroxyisophthalic acid dimethyl ester) is used as a building block in the chemical synthesis. | ||
| S6053 | Phenylglyoxylic acid | Phenylglyoxylic acid (Benzoyl formate, Phenylglyoxalic acid, Phenylglyoxylate) is a key building block in the field of chemical synthesis and is widely used to synthesize pharmaceutical intermediates or food additives. | ||
| E4661New | dWIZ-2 | dWIZ-2, is a molecular glue degrader of the WIZtranscription factor degrading WIZ with a DC50 of 32 nM. It also robustly induces fetal hemoglobin (HbF) in erythroblasts with an EC50 of 202 nM. | ||
| S9093 | Nardosinone | Nardosinone, isolated from Nardostachys root, an important Chinese herbal medicine, is an enhancer of nerve growth factor and possesses a wide range of pharmacological effects, including sedative, adaptogen-like, anti-depressive, anti-leukemic, anti-tumorous, and anti-trypanosomal activities. | ||
| S5827 | Citronellyl acetate | Citronellyl acetate (Citronellol acetate) is a natural flavouring ingredient. | ||
| S6063 | 1,11-Undecanedicarboxylic acid | 1,11-Undecanedicarboxylic acid (Tridecanedioic acid, Brassylic acid, Brassilic acid) is an unusual odd-numbered dicarboxylic acid that appears in the urines of children with neonatal adrenoleukodystrophy and Zellweger syndrome, as an additional marker of these peroxisomal disorders. | ||
| S3331 | 2-Aminoethylphosphonic acid | 2-Aminoethylphosphonic acid (2-AEP, (2-Aminoethyl)phosphonic acid) is a type of abundant and ubiquitous naturally occurring phosphonate used as sources of phosphorus by many prokaryotic lineages. |
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| S4448 | Imidacloprid-urea | Imidacloprid-urea with a role as a marine xenobiotic metabolite, is the primary imidacloprid soil metabolite, whereas imidacloprid-olefin is the main plant-relevant metabolite and is more toxic to insects than imidacloprid. | ||
| E2704 | Coomassie Blue R-250 | Coomassie Blue R-250 (Brilliant blue R250), an anionic dye, is the most popular stain to detect proteins resolved in SDS-PAGE gels. | ||
| E2942 | MES | MES (2-Morpholinoethanesulphonic acid) is a buffering agent in biology and biochemistry. It is one of the Good's buffers, the buffer capacity ranging pH 5.5-7.0. It is broadly used to regulate pH value for plants culture medium, reagent solution, and physiological experiments. | ||
| E1689 | NADPH tetrasodium salt | NADPH tetrasodium salt is a ubiquitous coenzyme that acts as an electron donor in many reactions utilizing dehydrogenase and reductase enzymes. It plays a crucial role as a cofactor in the biosynthesis of nucleotides, proteins, and fatty acids. It is essential for neutralizing elevated levels of reactive oxygen species (ROS) generated by increased metabolic activity. | ||
| S5407 | Squalane | Squalane (Perhydrosqualene, Dodecahydrosqualene) is a naturally occuring lipid in both plants and animals. It is usually used as an emollient and moisturizer in cosmetics manufacturing. | ||
| S9412 | Flavokawain B | Flavokawain B is a natural chalcone first isolated from extracts of kava roots that induces apoptosis in cancer cells. | ||
| S6431 | Damascenone | Damascenone is a potent flavor compound, possessing an extremely low odor threshold of 0.002 ppb in water. | ||
| S3335 | Phospho(enol)pyruvic acid monopotassium salt | Phospho(enol)pyruvic acid monopotassium salt (Potassium 1-carboxyvinyl hydrogenphosphate) is an endogenous metabolite. |
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| E0103 | TH263 | TH-263, a diaryl sulfonamide derivative, is inactive toward both LIMK1 and LIMK2 and thus can be used as negative control for TH-257. | ||
| E2702 | Tridecafluorohexane-1-sulfonic acid potassium salt | Tridecafluorohexane-1-sulfonic acid potassium salt is a perfluoroanionic surfactant, which is mainly used as a chromium mist inhibitor in electroplating, a wetting agent, and an additive in fluoroprotein foam fire extinguishing agents. | ||
| E4448 | EGTA tetrasodium | EGTA tetrasodium(Ethylene glycol-bis(β-aminoethyl ether)-N,N,N',N'-tetraacetic acid tetrasodium salt) is a calcium chelator, used for the determination of calcium in the presence of magnesium. EGTA tetrasodium significantly inhibits the substrate adherence capacity of inflammatory macrophages. | ||
| S1750 | Octocrylene | Octocrylene is an organic compound used as an ingredient in sunscreens and cosmetics. | ||
| S3882 | Brassinolide | Brassinolide, a plant steroid isolated from Brassica napus pollen, promotes cell elongation and cell devision and thus regulates plant growth and development. | ||
| S5167 | Benzyl cinnamate | Benzyl cinnamate (Cinnamein, Benzylcinnamoate, Benzyl 3-phenylpropenoate, Cinnamic acid benzyl ester), a flavouring agent isolated from various plant species, is used in heavy oriental perfumes and as a fixative. | ||
| S5830 | L-Xylose | L-Xylose is a synthesized levorotary form of Xylose, a sugar first isolated from wood. | ||
| S6066 | Methyl 4-aminobutyrate HCl | Methyl 4-aminobutanoate (GABA methyl ester) is a methyl ester resulting from the formal condensation of gamma-aminobutyric acid with methanol. | ||
| S3343 | Methyl β-D-Galactopyranoside | Methyl β-D-Galactopyranoside (Methyl beta-D-galactoside, Methylgalactoside) is an endogenous metabolite. |
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| E2703 | 3-Amino-9-ethylcarbazole | 3-Amino-9-ethylcarbazole (AEC) is a chemical compound commonly used as a chromogenic substrate in immunohistochemistry, specifically for visualizing sections stained with HRP-conjugated secondary antibodies. | ||
| E4105 | Quinizarin | Quinizarin (1,4-Dihydroxyanthraquinone) is a part of the anticancer agents such as Doxorubicin, Daunorubicin, and Adriamycin, interacts with DNA by intercalating mode. It is used as a fungicide and pesticide chemical and has shown the ability to inhibit tumor cell growth. | ||
| E4960New | L-Lysine hydrate | L-Lysine hydrate is a first-limiting, essential amino acid with important roles in connective tissues and carnitine synthesis, energy production, growth in children, and maintenance of immune functions. It also ameliorates vascular calcification by modifying several key pathways and attenuates pancreatic tissue injury induced by L-arginine by inhibiting the release of the inflammatory cytokine IL-6. | ||
| S5823 | L-Pyroglutamic acid | L-pyroglutamic acid (L-pyroglutamate, 5-Oxoproline, pidolic acid) is a natural nutrient and amino acid derived from glutamic acid. It is a metabolite in the glutathione cycle that is converted to glutamate by 5-oxoprolinase. | ||
| S6429 | Coniferyl alcohol | Coniferyl alcohol is an intermediate in biosynthesis of eugenol and of stilbene and coumarin. | ||
| S6679 | C25-140 | C25-140 is a small-molecule inhibitor of TRAF6-Ubc13 interaction. C25-140 directly binds to TRAF6, thereby blocking the interaction of TRAF6 with Ubc13, and as a consequence lowers TRAF6 activity. C25-140 impedes NF-κB activation in various immune and inflammatory signaling pathways also in primary human and murine cells. | ||
| S0623 | Bis-PEG1-NHS ester | Bis-PEG1-NHS ester is a noncleavable 1-unit PEG linker for antibody-drug-conjugation (ADC). | ||
| S3370 | 3-Methoxytyramine hydrochloride | 3-Methoxytyramine (3-O-methyl Dopamine, 3MT) hydrochloride, a major extracellular metabolite of dopamine, is a neuromodulator that in certain situations may be involved in movement control. |
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| E2941 | PIPES | PIPES (1,4-Piperazinediethanesulfonic acid) is an important component of PIPES buffer agent used in biochemistry. PIPES buffer in combination with glutaraldehyde and formaldehyde helps in optimal fixation of fungal zoospores for fluorescence microscopy and electron microscopy. | ||
| S2331 | Neohesperidin Dihydrochalcone (Nhdc) | Neohesperidin dihydrochalcone(Nhdc, NCI-c60764), sometimes abbreviated to neohesperidin DC or simply NHDC, is an artificial sweetener derived from citrus. | ||
| S5170 | Coumarin 6 | Coumarin 6 is a fluorescent dye frequently used to facilitate the traceability of drug delivery systems in vitro. | ||
| S6200 | Elsulfavirine | Elsulfavirine (Elpida, VM-1500) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) developed for the treatment and prevention of HIV-1 infection. | ||
| E0509 | chinifur | Chinifur, a selective inhibitor and "subversive substrate" for Trypanosoma congolense trypanothione reductase. | ||
| E1948New | ZT-1a | ZT-1a is a potent and selective, non-ATP-competitive inhibitor of STE20/SPS1-related proline-alanine-rich kinase (SPAK) with an IC50 of 44.3 μM. It can exhibit therapeutic potential for brain disorders linked to impaired ionic homeostasis in research. | ||
| S5076 | Xipamide | Xipamide is a sulfonamide-based diuretic as well as a saluretic with antihypertensive activity. | ||
| S9418 | Parishin B | Parishin B is a dominant active ingredient originating from Gastrodia elata Blume, and has good neuroprotective effects against brain disorders. | ||
| S6069 | trans-4-Hydroxycyclohexanecarboxylic Acid | trans-4-Hydroxycyclohexanecarboxylic acid is used as an organic intermediate. | ||
| E0818 | Quinupristin | Quinupristin, a streptogramin antibiotic, blocks peptide bond synthesis to prevent the extension of polypeptide chains and promote the detachment of incomplete protein chains in the bacterial ribosomal subunits. | ||
| E2962 | D-(+)-Malic acid | D-(+)-Malic acid (D-Malic acid), found in apples and many other fruits and plants is an active enantiomer of Malic acid. It is a competitive inhibitor of L(-)malic acid transport. | ||
| E4363 | L-Cystine (dihydrochloride) | L-Cystine dihydrochloride is used as a cell culture media component for the commercial biomanufacture of therapeutic recombinant proteins and monoclonal antibodies and as a sulfur-containing precursor of glutathione (GSH) synthesis. L-Cystine dihydrochloride homeostasis is also important for GSH functions. | ||
| E7144New | PAR-4 Agonist Peptide, amide | PAR-4 Agonist Peptide, amide is a agonist of proteinase-activated receptor-4 (PAR-4) that provides antinociceptive effects in stress- and inflammation-induced hyperalgesia. It reduces visceral pain by activating PAR-4 receptors on colonic nerve terminals. | ||
| S3704 | 4-Methylbenzylidene camphor | 4-Methylbenzylidene camphor (Enzacamene, 4-MBC) is an organic camphor derivative that is used in the cosmetic industry for its ability to protect the skin against UV, specifically UV B radiation. | ||
| S5327 | Meisoindigo | Meisoindigo (N-Methylisoindigotin, Methylisoindigotin, Dian III), a derivative of Indigo naturalis, is an active compound of a Chinese anti-leukemia medicine that has been effectively used in the treatment of chronic myelogenous leukemia (CML). | ||
| S5731 | Glyceryl tridecanoate | Glyceryl tridecanoate (Tricaprin, Tridecanoin, Glycerol tricaprate) is an orally available precursor of decanoic acid with potential antiandrogen and antihyperglycemic properties. | ||
| S6071 | 3,5-Dimethoxyphenol | 3,5-Dimethoxyphenol (Phloroglucinol dimethyl ether) is a toxin metabolite that can be found in human consuming yew (Taxus baccata) leaves. | ||
| S6449 | Ferrous Bisglycinate | Ferrous bisglycinate (Iron glycinate) is a chelate that is used as a source of dietary iron. It acts as both a chelate and a nutritionally functional.This product has poor solubility, animal experiments are available, cell experiments please choose carefully! | ||
| S5799 | Potassium guaiacolsulfonate hemihydrate | Potassium guaiacolsulfonate hemihydrate (Potassium Hydroxymethoxybenzenesulfonate, Sulfogaiacol) is used as an expectorant for relieving symptoms of cough and mucus in the chest due to respiratory infections, asthma, colds, or hay fever. | ||
| E0360 | (S)-Methoprene | (S)-Methoprene is a juvenile hormone analogue that prohibits the ability of the insect to change from pupae to adult. |
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| S5175 | (-)-Ambroxide | Ambroxide, a naturally occurring terpenoid, is one of the key constituents responsible for the odor of ambergris and an autoxidation product of ambrein. | ||
| S5090 | 4-Isopropylbenzyl Alcohol | 4-Isopropylbenzyl Alcohol (Cumic alcohol, Cuminyl alcohol, Cuminic alcohol), isolated from Eucalyptus camaldulensis, is a compound with insect repellent properties. | ||
| S5732 | Sebacic acid | Sebacic acid (1,8-Octanedicarboxylic acid) is a saturated, straight-chain naturally occurring dicarboxylic acid | ||
| S2255 | BMOV | BMOV (Bis maltolato oxovanadium, Bis(maltolato)oxovanadium (IV)) is a potent oral vanadium complex with anti-diabetic properties and insulin-mimicking effects.BMOV is shown to improve cardiac dysfunctions in diabetic models. | ||
| S3187 | SBI-477 | SBI-477 is an insulin signaling inhibitor that deactivates the transcription factor MondoA, leading to reduced expression of the insulin pathway suppressors thioredoxin-interacting protein (TXNIP) and arrestin domain-containing 4 (ARRDC4). SBI-477 inhibits triacylglyceride (TAG) synthesis and enhances basal glucose uptake in human skeletal myocytes. | ||
| S2336 | Orotic acid (6-Carboxyuracil) | Orotic acid(6-Carboxyuracil) is a heterocyclic compound and an acid. | ||
| S5091 | Geranyl acetate | Geranyl acetate (Geraniol acetate, Geranyl ethanoate) is a natural organic compound that is used primarily as a component of perfumes for creams and soaps and as a flavoring ingredient. | ||
| S6074 | 3-(3-Hydroxyphenyl)propionic Acid | 3-(3-Hydroxyphenyl)propionic acid (m-Hydroxyphenylpropionic acid, 3-Hydroxyhydrocinnamic acid) is one of the major metabolites of ingested caffeic acid and of the phenolic degradation products of proanthocyanidins by the microflora in the colon. | ||
| E2940 | Bromophenol Blue | Bromophenol blue is an acid phthalein dye, and it is used as a tracking dye for electrophoresis. Bromophenol blue is also used as a pH indicator, with a transition range of pH 3 to 4.6. It helps to detect proteins and nucleic acids (absorbance at 610 nm), particularly when staining living tissues. | ||
| S3803 | Angelic acid | Angelic acid ((Z)-2-Methylbut-2-enoic acid) is a monocarboxylic unsaturated organic acid that is mostly found in the plants of the family Apiaceae. | ||
| S9103 | Ginsenoside Ro | Ginsenoside Ro (Chikusetsusaponin V), one of the high-abundance saponins in ginseng, is widely used as a dietary supplement and has many health-promoting effects. | ||
| S9422 | Diosbulbin B | Diosbulbin B is the main hepatotoxic compound in Airpotato yam, which is traditionally used for treating thyroid disease and cancer. | ||
| S6445 | Chlorophyllin (sodium copper salt) | Chlorophyllin, the sodium and copper salt of chlorophyll, is an antioxidant and antimutagenic agent. | ||
| E2961 | Phosphatase substrate | Phosphatase substarte (4-Nitrophenyl phosphate disodium hexahydrate, p-nitrophenyl phosphate disodium hexahydrate) is widely used as a small molecule phosphotyrosine-like substrate in activity assays for protein tyrosine phosphatases. It is a colorless substrate that upon hydrolysis is converted to a yellow 4-nitrophenolate ion that can be monitored by absorbance at 405 nm. | ||
| E4112 | Menthol | Menthol is a natural analgesic compound that causes a feeling of coolness due to stimulation of ‘cold’ receptors by inhibiting Ca++ currents of neuronal membranes. | ||
| S4607 | 2,2′-Dihydroxy-4-methoxybenzophenone | 2,2′-Dihydroxy-4-methoxybenzophenone (Dioxybenzone, Dioxybenzon, Advastab 47, Cyasorb UV 24, Benzophenone-8) is an organic compound used in sunscreen to block UVB and short-wave UVA (ultraviolet) rays. | ||
| S4764 | Melezitose | Melezitose, also spelled melicitose, is a nonreducing trisaccharide sugar that is produced by many plant sap eating insects. | ||
| S5660 | Clodronate disodium tetrahydrate | Clodronate disodium tetrahydrate (clodronic acid) is a diphosphonate which affects calcium metabolism. It inhibits bone resorption and soft tissue calcification. | ||
| S9104 | Maltopentaose | Maltopentaose is a substrate for energy metabolism and carbon for E. coli. | ||
| S9423 | Narcissoside | Narcissoside has antioxidant and antiproliferative activity in cancer. | ||
| S0630 | Mal-PEG6-NHS ester | Mal-PEG6-NHS ester is a non-cleavable ADC linker containing a Maleimide group, 6-unit PEG and a NHS ester. | ||
| S3310 | D-(+)-Galacturonic acid monohydrate | D-(+)-Galacturonic acid monohydrate (D-Galacturonic acid hydrate, d-GalA, D-galUA) is an endogenous metabolite that can be used in engineering Saccharomyces cerevisiae. |
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| E2954 | Ethyl methanesulfonate | Ethyl methanesulfonate is a DNA ethylating agent, mutagenic to plants and animals and carcinogenic in mammals. It has been used as a model alkylating agent in studies of DNA repair processes. It induces base substitutions of guanine-cytosine (G/C) to adenine-thymine (A/T). EMS also generates point mutations and single nucleotide polymorphisms in genomes. | ||
| E4447 | Coenzyme Q1 | Coenzyme Q1 (CoQ1) is localized to the hydrophobic domain of the phospholipid bilayer of mitochondria, plasma lipoproteins, and other biological membranes. CoQ1 reduction has a strong rotenone-insensitive component and can be used to measure the mitochondrial respiratory chain complex 1 activity. | ||
| S4224 | Erythritol | Erythritol(meso-Erythritol) is a sugar alcohol used as low-calorie sweetener. | ||
| S5599 | Sodium cholate | Sodium cholate (NaCh) is the sodium salt of the naturally occurring cholic acid, a bile salt produced by the liver, with strong solubilization capacity of water-insoluble substances. | ||
| S6076 | Phenylacetylglutamine | Phenylacetylglutamine is a product formed by the conjugation of phenylacetate and glutamine. It is a normal constituent of human urine, but other mammals such as the dog, cat, rat, monkey, sheep, and horse do not excrete this compound. | ||
| S6446 | Sodium citrate dihydrate | Sodium citrate dehydrate (Trisodium citrate dihydrate, Citric acid trisodium salt dihydrate) is the preferred anticoagulant. | ||
| S3323 | 2-Hydroxycaproic acid | 2-Hydroxyhexanoic acid (2-Hydroxyhexanoic acid) is an endogenous metabolite. |
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| E2967 | Triethylenediamine | Triethylenediamine (1,4-Diazabicyclo[2.2.2]octane, DABCO), is a caged tertiary diamine commonly used as a strong hindered amine base in chemical synthesis. It is used in the synthesis of isoxazole derivatives via dehydration of primary nitro compounds in the presence of dipolarophiles. It can also be employed as a complexing ligand and as a catalyst. | ||
| E4114 | Arabinose | Arabinose((±)-Arabinose; DL-Arabinose; dl-Arabinose) is an endogenous metabolite. It is a natural sugar molecule that exhibits sweetness profiles similar to sucrose, making it a valuable alternative in low-calorie foods and excipients or cocrystallization agents in pharmaceutical formulations. | ||
| P1169 | Protamine sulfate | Protamine sulfate is a polycationic, highly positively charged protein derived from salmon sperm protein, used to neutralize unfractionated heparin administration (UFH)-induced anticoagulation following cardiovascular surgical procedures. | ||
| S4767 | 7-Hydroxy-3,4-dihydrocarbostyril | 7-Hydroxy-3,4-dihydrocarbostyril is used as the materials for the organic synthesis intermediates. | ||
| S5575 | 2-Benzoxazolinone | 2-Benzoxazolinone (BOA, 2-Hydroxybenzoxazole), a well-known allelochemical with strong phytotoxicity, is a potential herbicidal candidate and probably functions via interfering with auxins or disrupting membrane integrity. | ||
| S6450 | Apronal | Apronal (Apronalide, Allylisopropylacetylurea, Allylisopropylacetylcarbamide) is a hypnotic/sedative drug. | ||
| E2968 | Zinc sulfate heptahydrate | Zinc sulfate heptahydrate is a hydrate that is the heptahydrate form of zinc sulfate. Zinc sulfate heptahydrate is a dietary supplement used for zinc deficiency and can also accelerate the rate of healing. It is also used in prepration of zinc tris(thiourea) sulphate (ZTS), a semiorganic nonlinear optic (NLO) material that may be useful in laser fusion experiments and in second-harmonic-generation (SHG) devices. | ||
| S4768 | Melibiose | Melibiose (Galalpha1-6Glcbeta) is a nondigestible disaccharide that consists of one galactose and one glucose moiety in an alpha (1-6) glycosidic linkage. | ||
| S5677 | Xanthopterin Hydrate | Xanthopterin, isolated from butterfly wings and found in many other sources, replace folic acid in the nutrition of many animal species. | ||
| S6081 | 5-Hydroxymethyl-2-furancarboxylic acid | 5-Hydroxymethyl-2-furancarboxylic acid is the main metabolite of 5-hydroxymethyl-2-furfural, a product of acid-catalyzed degradation of sugars during the heating and storage of foods that influences taste and physiological functions in the body. | ||
| S6440 | Halazone | Halazone (Pantocide, p-sulfondichloramidobenzoic acid) is widely used to disinfect drinking water. | ||
| E0029 | Hexa-D-arginine | Hexa-D-arginine is a potent and specific furin inhibitor with Ki values of 106 nM, 580 nM, and 13.2 μm for furin, PACE4, and PC1, respectively. | ||
| E1716 | SR9011 | SR9011 is a REV-ERBα/β agonist with IC50s of 790 nM and 560 nM for REV-ERBα and REV-ERBβ, respectively. It is specifically lethal to cancer cells and oncogene-induced senescent cells, including melanocytic naevi. | ||
| E4889New | Glafenine | Glafenine (Glafenin) is a non-steroidal anti-inflammatory drug (NSAID) and is a non-narcotic analgesic agent that not only acts as a proteostasis modulator but is also one of the most potent NSAID correctors of F508del-CFTR. It exhibits COX-2 inhibition in the arachidonic acid pathway and rescues class 2 CFTR mutants. | ||
| E4716New | QS11 | QS11 acts as an inhibitor of ARFGAP1 (ADP-ribosylation factor GTPase-activating protein 1), with an EC50 of 1.5 μM. QS11 regulates Wnt/β-catenin signaling by interacting with ARF GTPase-activating protein 1 (ARFGAP1) and influences protein trafficking. Additionally, QS11 suppresses the migration of breast cancer cells that overexpress ARFGAP1. | ||
| S7452 | FPH2 (BRD-9424) | FPH2 (BRD-9424) is a small molecule, which promotes differentiation of iPS-derived hepatocytes. | ||
| S4807 | Uracil 1-β-D-arabinofuranoside | Uracil 1-β-D-arabinofuranoside (Spongouridine, Arauridine, 1-beta-D-Arabinofuranosyluracil, Ara-U) is a deamination metabolite of Cytarabine. | ||
| S9108 | Timosaponin A3 | Timosaponin A3 (Filiferin B, AneMarsaponin A3), one of the major steroidal saponin components isolated from Anemarrhena asphodeloides, displays promising pharmacological activity in improving learning, memory, and antineoplastic activity. | ||
| S6441 | Riboflavin Tetrabutyrate | Riboflavin tetrabutyrate is a lipophilic flavin derivative with antioxidative and lipid peroxide-removing activity. | ||
| D4004 | Patritumab deruxtecan | Patritumab deruxtecan (HER3-DXd) is an antibody-drug conjugate (ADC) composed of a fully human anti-HER3 IgG1 monoclonal antibody and a cytotixic topoisomerase I inhibitor. Patritumab deruxtecan shows anticancer activity. | ||
| E4997New | BAY 2927088（Sevabertinib） | BAY 2927088（Sevabertinib) is the first non-covalent, potent, oral, selective, and reversible inhibitor of tyrosine kinase that potently inhibits mutant HER2 and mutant EGFR in preclinical models. It targets Exon 20 insertions in non-small-cell lung carcinoma (NSCLC) patients. | ||
| S9109 | 1-Kestose | 1-Kestose (1F-beta-D-Fructosylsucrose), a fructooligosaccharide, could efficiently stimulates Faecalibacterium prausnitzii as well as Bifidobacteria in humans. | ||
| S9429 | 6α-Hydroxygeniposide | 6α-Hydroxygeniposide, an iridoid glycoside, is a chemical constituents of Pittosporum glabratum Lindl. | ||
| S6091 | Glycodeoxycholic acid sodium salt | Glycochenodeoxycholic acid (GCDC, Glycodeoxycholate, Deoxycholylglycine) is a bile salt that is used as an anionic detergent to solubilize lipids. | ||
| S9677 | NCGC00378430 | NCGC00378430 is an inhibitor of the SIX1/EYA2 complex that significantly suppresses breast cancer-associated metastasis in vivo without significantly altering primary tumor growth. | ||
| E0446 | ALC-0159 | ALC-0159 is a polyethylene glycol (PEG) lipid conjugate. ALC-0159 allows forming a hydrophilic layer that sterically stabilizes the nanosystem, contributing to storage stability and reducing non-specific binding to proteins. |
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| E2683 | Ursodeoxycholic acid sodium | Ursodeoxycholic acid sodium is a sodium salt of a naturally occurring bile acid that is used to treat a variety of hepatic and gastrointestinal diseases. | ||
| E4118 | (-)-Menthone | (-)-Menthone is a monoterpene component of the essential oil of maturing peppermint. (+)-Neomenthyl-β-d-glucoside is a metabolite of (-)-Menthone. Mortality of two biological forms of Anopheles stephensi (larvae) exposed to about 45 ppm (-)-Menthone is 27.67% and 94.92%. | ||
| E5777New | Tris(benzyltriazolylmethyl)amine | Tris(benzyltriazolylmethyl)amine (TBTA) is a ligand used as a biochemical tool for labeling proteins and enzymes. It dramatically enhances the Copper(II) acetate (Cu(OAc)2)-accelerated azide-alkyne cycloaddition (AAC) reactions involving nonchelating azides. | ||
| S4704 | D-(+)-Cellobiose | D-(+)-Cellobiose (Cellobiose, Cellose, Beta-Cellobiose, D-Cellobiose) is a substrate of β-glucosidase. | ||
| S3806 | Angelic anhydride | Angelic anhydride (2-Methylisocrotonic Anhydride, (Z)-2-Methylbut-2-enoic anhydride) is a synthetic chemical and usually used in content determination assays and pharmacological experiments. | ||
| S6092 | cis,cis-Muconic acid | cis,cis-Muconic acid (cis,cis-Muconate; cis,cis-2,4-Hexadienedioic acid; cis,cis-2,4-Hexadienedioate) is a polyunsaturated dicarboxylic acid that can be produced renewably via the biological conversion of sugars and lignin-derived aromatic compounds. | ||
| S6436 | magnesium 2-aminoacetate | Magnesium 2-aminoacetate (Magnesium glycinate) is essential for DNA and RNA synthesis, cellular repair, and maintaining the antioxidant status of the cell. | ||
| S6370 | Dendrophenol | Dendrophenol (Moscatilin) is from Dendrobium nobile, a naturally occurring bibenzyl compound with potential antimutagenic activity. | ||
| E0447 | SM-102 | SM-102 is a amino cationic lipid used to form the nanoparticle which carries the mRNA to cells in the body. |
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| E2696 | 11-Mercaptoundecanoic acid | 11-Mercaptoundecanoic acid (MUA) is a thiol-containing fatty acid, which has been described in the preparation of self-assembled monolayers (SAMs), mixed monolayers, and metal-associated nanoparticles. | ||
| E2955 | Pectin | Pectin is a heteropolysaccharide, derived from the cell wall of higher plants. It involves in the formation of nanoparticles as a delivery vehicle of agents. It also acts as an adsorbent, a broad-spectrum antimicrobial agent that binds to bacteria toxins and other irritants in the intestinal mucosa, relieves irritated mucosa. | ||
| S9353 | L-serine | L-serine, one of the so-called non-essential amino acids, plays a central role in cellular proliferation. | ||
| S2428 | Isopropyl myristate | Isopropyl myristate (IPM) is used as a substitute for natural oils in cosmetics and a co-solvent with skin penetration enhancement properties of active ingredients in many topical and transdermal preparations. It affects the lamellar lipid assembly in terms of bilayer perturbation and disordering. | ||
| S4465 | VPC-80051 | VPC-80051 is an potent inhibitor of hnRNP A1 splicing activity that targets hnRNP A1 RBD and reduces AR-V7 messenger levels in 22Rv1 CRPC cell line. | ||
| E2250 | IBT6A | IBT6A is an impurity of Ibrutinib, which is a selective, irreversible Bruton tyrosine kinase (Btk) inhibitor with an IC50 of 0.5 nM. | ||
| E2953 | MES hydrate | MES hydrate is one of the Good′s buffers, the most extensively used biological buffers. MES is a zwitterionic N-substituted aminosulfonic acid with a morpholinic ring. MES hydrate has been used in the MS (Murashige and Skoog) media for growth of Arabidopsis seedlings. It has been added in the cytoskeleton buffer during immunofluorescence study. | ||
| S5112 | alpha-Arbutin | Alpha-arbutin (alpha-Arbutoside, 4-hydroxyphenyl-D-lucopyranoside) is a synthetic and functional active ingredient for skin lightening. | ||
| S5085 | Azamethiphos | Azamethiphos is an organophosphate (OP) pesticide used to combat sea lice infestations in farmed salmonids. | ||
| S6095 | Quinoline-4-carboxylic acid | Quinoline-4-carboxylic acid (4-Carboxyquinoline) is a very important structure in a synthetic medicinal chemistry. | ||
| E1798New | HOIPIN-8 | HOIPIN-8, is a potent inhibitor of linear ubiquitin chain assembly complex (LUBAC) and NF-κB signaling with an IC50 value of 11 nM. It serves as a powerful tool for investigating the physiological and cellular functions of LUBAC. | ||
| S5114 | Hydroquinine | Hydroquinine (Dihydroquinine), also known as dihydroquinine, is an organic compound and as a cinchona alkaloid closely related to quinine. | ||
| S5586 | 3-Hydroxycinnamic acid | 3-hydroxycinnamic acid (meta-Coumaric acid, m-Coumaric acid, m-Coumarate) is an aromatic acid that can be found in vinegar. | ||
| S9349 | D-(+)-Raffinose pentahydrate | Raffinose is a trisaccharide composed of galactose, glucose, and fructose. | ||
| S6096 | 5-Phenylvaleric Acid | 5-Phenylvaleric acid (Benzenepentanoic acid, Phenylpentanoic acid, Phenylvaleric Acid) is a Pentanoic acid of bacterial origin, occasionally found in human biofluids. | ||
| E2701 | Sodium phosphate monobasic monohydrate | Sodium phosphate monobasic monohydrate is a commonly used buffer which can be used in high-performance liquid chromatography. | ||
| S3102 | Creatinine | Creatinine(NSC13123) is a break-down product of creatine phosphate in muscle, and is usually produced at a fairly constant rate by the body. | ||
| S3812 | Monocrotaline | Monocrotaline (MCT, Crotaline) is an 11-membered macrocyclic pyrrolizidine alkaloid (PA) that causes a pulmonary vascular syndrome in rats characterized by proliferative pulmonary vasculitis, pulmonary hypertension, and cor pulmonale.Monocrotaline can be used to induce animal models of Pulmonary Hypertension. | ||
| S9346 | 1-Indanone | 1-Indanone (Indan-1-one, Alpha-Indanone) is an oxidation product of Indan, a component of fuels, solvents, and varnishes. It is part of the steroid hormone biosynthesis, and arachidonic acid metabolism pathways. | ||
| S9434 | 8-Gingerol | 8-Gingerol is a bioactive ingredient of ginger root (Zingiber officinale), a medicinal plant having anti-nausea, anti-inflammatory, and anti-carcinogenic properties and a carminative effect. | ||
| S6097 | 3-Furoic acid | 3-Furoic acid is an organic acid regularly occurring in urine of healthy individuals. | ||
| E0201 | Hypaconitine | Hypaconitine (Hypaconitine) is an active diterpene alkaloid derived from Aconitum species. Hypaconitine inhibits TGF-β1-induced epithelial–mesenchymal transition. | ||
| S5116 | Bilibubin | Bilibubin (Bilirubin) is a tetrapyrrole and a breakdown product of heme catabolism that acts as a physiological, chain-breaking antioxidant. | ||
| S5614 | (+)-Longifolene | (+)-Longifolene is a naturally occurring, oily liquid hydrocarbon found primarily in the high-boiling fraction of certain pine resins | ||
| S9435 | Secoxyloganin | Secoxyloganin is a secoiridoids that is extensively used in synthetic and biosynthetic studies of monoterpene indole alkaloids and related natural products. | ||
| S6098 | 2-Hydroxy-3-methylbutanoic acid | 2-Hydroxy-3-methylbutanoic acid (3-Methyl-2-hydroxybutyric acid, 2-Hydroxyisopentanoic acid, 2-Oxyisovaleric acid) is a metabolite found in the urine of patients with phenylketonuria, methylmalonic acidemia, propionic acidemia, 3-ketothiolase deficiency, isovaleric acidemia, 3-methylcrotonylglycemia, 3-hydroxy-3-methylglutaric acidemia, multiple carboxylase deficiency, glutaric aciduria, ornithine transcarbamylase deficiency, glyceroluria, tyrosinemia type I, galactosemia, and maple syrup urine disease. | ||
| S9713 | Racemetyrosine (SM-88) | Racemetyrosine (SM-88, Racemetirosine, DL-alpha-metyrosine, DL-alpha-Methyltyrosine) is a novel anti-cancer agent, used with melanin, phenytoin (a CYP3a4 inducer), and sirolimus (an mTOR inhibitor) (SMK Therapy). | ||
| E0748 | Opoponax oil | Opoponax oil is isolated and extracted from Commiphora erythraea (opoponax), with a promising insecticidal property. | ||
| E1637New | ALKBH5 inhibitor 1 (compound 3) | ALKBH5 inhibitor 1 (compound 3) is an inhibitor of the RNA m6A Demethylase ALKBH5, with an IC50 value of 0.84 μM. It also exhibits potent antiproliferative activity. | ||
| S5117 | Doramectin | Doramectin (Cyclohexylavermectin B1, Dectomax) is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening in nematodes. It is used for the treatment and control of internal parasitosis, ticks and mange. | ||
| S2474 | Fabomotizole hydrochloride | Fabomotizole hydrochloride (Fabomotizole, CM346, CM346, Afobazol, Afobazole) exhibits anxiolytic and neuroprotective properties. Fabomotizole hydrochloride is a potent sigma1-receptor agonist with IC50 of 7.1 µM and Ki of 5.9 µM. | ||
| E0503 | Borofalan (10B) | Borofalan (10B) (SPM-011; Steboronine), a Ionising radiation emitter, can be used to treat the head and neck cancer. | ||
| S3887 | α-L-Rhamnose monohydrate | α-L-Rhamnose monohydrate (6-deoxy-L-mannose monohydrate, α-L-Rhamnopyranose monohydrate) is used as a starting material for the production of furanones. It is an important material involved in the reaction of flavors developed during the preparation of various foods like bread, grilled meats, etc. | ||
| S4769 | L-5-Hydroxytryptophan | 5-Hydroxytryptophan (5-HTP, L-oxitriptan), also known as oxitriptan, is a naturally occurring amino acid and chemical precursor as well as a metabolic intermediate in the biosynthesis of the neurotransmitter serotonin. | ||
| S5089 | 4-Isopropylbenzaldehyde | 4-Isopropylbenzaldehyde (Cuminaldehyde, Cuminic aldehyde, Cuminal), a natural organic compound, is a kind of pharmaceutical intermediate with a pleasant smell and contributes to the aroma of essential oils. | ||
| S9359 | Anthraquinone-2-carboxylic Acid | Anthraquinone-2-carboxylic Acid is a novel electron shuttling mediator, showing potent anti-inflammatory and antinociceptive activities in vivo. | ||
| S6105 | trans-3-Indoleacrylic acid | trans-3-Indoleacrylic acid is a metabolite of tryptophan. | ||
| E0738 | Gipsoside | Gypenoside is a triterpene saponin from gypsophila paniculata L. | ||
| E2520 | WAY-358871 | WAY-358871 is a bioactive compound. | ||
| E2966 | Lysophosphatidylcholines | Lysophosphatidylcholines are a class of chemical compounds which are derived from phosphatidylcholines. Lysophosphatidylcholine is produced from phospholipids by the action of phospholipase A2 (PLA2). It also has pro-inflammatory properties through its activation and modulation of various signaling pathways, including the ERK pathway as well as through protein tyrosine kinase and G protein-coupled receptor (GPCR) signal transduction. It plays a critical role in allergic airway disease manifestation. | ||
| S4233 | Zoxazolamine | Zoxazolamine (NSC 24995, Contrazole) is a centrally acting myorelaxant, which is formerly used as an antispasmodic and uricosuric. | ||
| S4510 | 4-Aminobenzoic acid | 4-Aminobenzoic acid (para-Aminobenzoic acid) is an intermediate in the synthesis of tetrahydrofolic acid in many non-mammalian organisms, including bacteria and fungi. | ||
| S5583 | Cinnamyl acetate | Cinnamyl acetate (3-Phenylallyl acetate) is a naturally occuring compound used as a flavouring agent. | ||
| S9004 | Chondroitin 4-sulfate | Chondroitin 4-sulfate is an important structural component of cartilage and has been used as a dietary supplement to treat symptoms of joint discomfort. | ||
| S9119 | Leonuride | Leonuride (Ajugol), an active alkaloid that is extracted from Traditional Chinese Medicine Herba leonuri, is a terpene glycoside that can be used for some gynecological disease. | ||
| S9438 | Isosakuranetin | Isosakuranetin (4'-Methylnaringenin), an O-methylated flavonoid, is the 4'-methoxy derivative of naringenin, a flavanone found in Citrus species. | ||
| S6110 | 2-Methylpentanedioic acid | 2-Methylglutaric acid (alpha-Methylglutaric acid) is a metabolite of succinic acid, a citric acid cycle intermediate. | ||
| S2272 | Indoprofen | Indoprofen is a nonsteroidal anti-inflammatory drug (NSAID) and cyclooxygenase (COX) inhibitor. Indoprofen prevents muscle wasting in aged mice through activation of PDK1/AKT pathway.Indoprofen selectively increases SMN2-luciferase reporter protein and endogenous SMN protein. | ||
| E2963 | Carmine | Carmine (Carmine red), a natural red dye extracted from the dried females of the insect Dactylopius coccus var. Costa (cochineal). Carmine is a widely used food additive. Carmine provokes both an immediate hypersensitivity and a delayed systemic response with cutaneous expression. | ||
| E4782New | 17-OH PREG (17a-Hydroxypregnenolone) | 17-OH PREG (17a-Hydroxypregnenolone) is a pregnenolone metabolite and DHEA precursor. It is formed through CYP17A1 hydroxylase and 17,20-lyase activities. It is the most relevant steroid for the study of elevated plasma levels linked to type II 3β-hydroxysteroid dehydrogenase deficiency. | ||
| S0196 | Tirasemtiv (CK-2017357) | Tirasemtiv (CK-2017357, CK-357) is a direct fast skeletal muscle troponin activator that sensitizes the sarcomere to calcium. | ||
| S3104 | Moguisteine | Moguisteine(BBR-2173) is a novel peripheral non-narcotic antitussive drug. | ||
| S9375 | 2'-Hydroxyacetophenone | 2'-Hydroxyacetophenone is a flavouring ingredient. | ||
| S3351 | Sodium phenylpyruvate | Sodium phenylpyruvate (Phenylpyruvic acid sodium salt) inhibits amino acid formation and depresses oxygen consumption. | ||
| S3743 | Oxiglutatione | Oxiglutatione (Oxidized glutathione, Glutathione disulfide, GSSG, Bi(glutathion-S-yl)) is the oxidized disulfide form of glutathione (GSH) with potential protective activity. | ||
| S3891 | Vincamine | Vincamine (Angiopac, Devincan, Equipur, Minorin, Novicet, Oxybral, Perval, Sostenil, Tripervan), an indole alkaloid found in the leaves of V. minor and C. roseus, is a peripheral vasodilator that increases blood flow to the brain. | ||
| S9379 | Dihydrocoumarin | Dihydrocoumarin, a compound found in Melilotus officinalis (sweet clover) and Dipteryx odorata Willd (tonka beans), is added as a flavoring agent to a wide variety of foods, including soft drinks, yogurt, and muffins, and is used as a common fragrance in cosmetics, lotions, and soaps. | ||
| S6113 | Tridecanoic acid | Tridecanoic acid (Tridecylic acid) is a 13-carbon saturated fatty acid found in many foods, some of which are nutmeg, muskmelon, black elderberry, and coconut. | ||
| E2951 | D-Desthiobiotin | D-Desthiobiotin(Dethiobiotin) is a biotin derivative used in affinity chromatography and protein chromatography. D-Desthiobiotin also can be used for protein cross-linking agent, protein and cell labeling, detection and isolation. | ||
| S5838 | SDMA | SMDA (symmetric dimethylarginine) is a methylated form of arginine found within all nucleated cells that is released into circulation after proteolysis, then excreted through the kidneys, and correlates well with GFR (glomerular filtration rate) in people, dogs, and cats. | ||
| S6114 | D-Arabitol | D-Arabitol is a water soluble sugar alcohol. | ||
| E7386New | Fructose | Fructose (beta-D-Fructopyranose) is a highly soluble, sweet monosaccharide used as a sweetener in food and beverages, providing moisture retention and enhancing flavor. It functions as a humectant, lowers freezing points, and improves texture in various products. | ||
| S4519 | Citric acid trilithium salt tetrahydrate | Citric acid trilithium salt tetrahydrate (Trilithium citrate tetrahydrate, Lithium citrate tribasic tetrahydrate) is a pharmaceutical and construction material. It is commonly used in HPLC gradient elution for quantification of amino acids. | ||
| S9373 | Neryl acetate | Neryl acetate (Nerol, Acetic acid neryl ester, cis-Geranyl), a chemical compound found in citrus oils, is a flavouring agent. | ||
| S9443 | Schisantherin B | Schisantherin B is one bioactive of lignans isolated from Schisandra chinensis (Turcz.) Baill which has been commonly used as a traditional herbal medicine. | ||
| S6121 | Maltotriose | Maltotriose is a trisaccharide consisting of three glucose molecules linked with α-1,4 glycosidic bonds. It is a common oligosaccharide metabolite found in human urine after maltose ingestion or infusion. | ||
| S6908 | DOTAP chloride | DOTAP chloride (1,2-Dioleoyl-3-trimethylammonium-propane chloride) is an effective cationic lipid widely used as a liposomal transfection reagent. DOTAP is also a strong activator of the innate immune system in animal cells and a good candidate as an elicitor for the study of plant immunity. | ||
| D4007 | Clivatuzumab-MMAE | Clivatuzumab-MMAE is an antibody-drug conjugate (ADC) composed of a humanized anti-mucin (MUC1) monoclonal antibody and a anti-mitotic cytotoxic agent monomethyl auristatin (MMAE). | ||
| S3919 | Hederacoside C | Hederacoside C (HDC, Kalopanaxsaponin B) is one of the active ingredients in Hedera helix leaf extract (Ivy Ex.) and used to treat respiratory disorders. | ||
| S9381 | 5-Methyl furfural | 5-Methyl furfural is an important chemical intermediate. | ||
| S9126 | Schizandrol B | Schizandrol B (Gomisin A, Besigomsin, Wuweizi alcohol B, Gamma-Schisandrin), extracted from the fruit of Schisandra chinensis Baill., exhibits potent antitumor activities. | ||
| S6123 | DL-Benzylsuccinic acid | DL-Benzylsuccinic acid (2-benzylbutanedioic acid, Benzylsuccinic acid) is a bacterial xenobiotic metabolite. | ||
| S2426 | Tirapazamine | Tirapazamine (NSC 130181, SR 259075, SR 4233, Tirazone, WIN 59075) is a new anticancer drug in solid tumours. Tirapazamine exhibits preferential tumour cell killing and high specific toxicity to cells at low oxygen tensions. | ||
| S9339 | S-(-)-Cotinine | S-(-)-Cotinine, a constituent of tobacco products and the major metabolite of nicotine, stimulates nicotinic receptors to evoke the release of DA in a calcium-dependent manner from superfused rat striatal slices. | ||
| S4778 | o-Veratraldehyde | o-Veratraldehyde (2,3-Dimethoxybenzaldehyde) is used as the materials for the organic synthesis intermediates. | ||
| S6127 | 5-Hydroxymethyluracil | 5-Hydroxymethyluracil (5hmU) is a thymine base modification found in the genomic DNA of diverse organisms ranging from bacteriophages to mammals | ||
| E0750 | Dihydrouracil | Dihydrouracil (5,6-Dihydrouracil) is an intermediate in the catabolism of uracil. Dihydrouracil (5,6-Dihydrouracil) can be used as a standard for ureido group in the colorimentric assay of transfer ribonucleic acid (tRNA). | ||
| S3896 | (1R,2R)-trans-N-Boc-1,2-cyclohexanediamine | (1R,2R)-trans-N-Boc-1,2-cyclohexanediamine is an intermediate in organic synthesis. | ||
| S9447 | 1F-Fructofuranosylnystose | 1F-Fructofuranosylnystose is a kind of Fructooligosaccharides which are naturally occurring sugars with potentially beneficial nutritional effects. | ||
| S6131 | 2-Oxo-3-phenylpropanoic acid | 2-Oxo-3-phenylpropanoic acid (Phenylpyruvic acid) is used in the synthesis of 3-phenyllactic acid (PLA) by lactate dehydrogenase. | ||
| S3729 | Iron sucrose | Iron sucrose (Iron saccharate, Sucroferric oxyhydroxide) is an intravenously administered iron product indicated in the treatment of iron deficiency anemia. | ||
| S5375 | γ-Decalactone | γ-Decalactone (4-Decanolide, 5-Hexyldihydro-2(3H)-furanone) is a naturally occuring flavor compound, being important in industry with a peachy aroma. | ||
| S9130 | Rubusoside | Rubusoside is a natural sweetener and a solubilizing agent with antiangiogenic and antiallergic properties. | ||
| S9554 | Bakkenolide A | Bakkenolide A (Fukinanolid), extracted from Petasites tricholobus, has been suggested to against cancer and display protective effects on inflammatory cytokines formation. | ||
| E0832 | Compound 10w | Compound 10w, a substituted pyrazolo [1,5-a] pyrimidine amide derivative, shows good anticancer activity against HeLa cell line, with IC50 of less than 10 µM against HeLa cell. | ||
| S4530 | i-Inositol | i-Inositol, also known as myo-inositol, is a chemical compound which is sugar alcohol. i-Inositol is involved in a number of biological processes including insulin signal transduction, cytoskeleton transduction and so on. | ||
| S5376 | Decyl aldehyde | Decyl aldehyde (Decanal, Capraldehyde, Decanaldehyde) is a naturally occuring organic compound that is used in fragrances and flavoring. | ||
| S6454 | DHA (Docosahexaenoic Acid) | DHA (Docosahexaenoic Acid) is essential for the growth and functional development of the brain in infants. DHA is also required for maintenance of normal brain function in adults. | ||
| E0037 | Bradykinin | Bradykinin is a potent vasodilator peptide that exerts its vasodilatory action through stimulation of specific endothelial B2 receptors, thereby causing the release of prostacyclin, NO, and EDHF. | ||
| E0181 | Zinc acetate dihydrate | Zinc acetate dihydrate (Acetic acid zinc salt dihydrate, Dicarbomethoxyzinc dihydrate) contributes to the antiviral activity of microbicide gel through zinc targeting the reverse transcriptase. | ||
| D4015 | Farletuzumab-MMAE | Farletuzumab-MMAE is an antibody-drug conjugate (ADC) composed of humanized anti-human folate receptor-alpha (FRα) and the cytotoxic agent monomethyl auristatin (MMAE) via a MC-Vc linker. It has a potent antitumor activity. | ||
| S4531 | Iohexol | Iohexol (Omnipaque) is a radiographic contrast agent that can be used as an exogenous filtration marker for accurate glomerular filtration rate (GFR) estimates. | ||
| S5377 | Dibutyl phthalate | Dibutyl phthalate is widely used as plasticizer in numerous kinds of products such as plastic packaging in food industries. | ||
| S9487 | Praeruptorin C | Praeruptorin C is a natural compound derived from the dried roots of Peucedanum praeruptorum and has beneficial effects in suppressing osteoclast formation and resorption function. It is frequently utilized in traditional Chinese medicine for treating upper respiratory infections and as an antipyretic, antitussive, and mucolytic agent. | ||
| S6139 | Piperonyl acetone | Piperonyl acetone is a food additive used in food flavouring. | ||
| S0447 | ASP7663 | ASP7663 is an orally bioavailable selective activator of transient receptor potential ankyrin 1 (TRPA1). ASP7663 activates human, rat and mouse TRPA1 receptors with EC50 of 510 nM, 540 nM and 500 nM, respectively. ASP7663 acts by stimulating 5-HT release from QGP-1 cells and exhibiting an abdominal analgesic effect in vivo. | ||
| E0038 | [SER140]-PLP(139-151) | [SER140]-PLP(139-151) is a polypeptide fragment of the lipid protein of myelin. | ||
| E0834 | 7,8-Dimethoxy-4H-chromen-4-one | 7,8-Dimethoxy-4H-chromen-4-one is a bioactive compound. | ||
| S4532 | Iopamidol | Iopamidol (Iopamiro, Isovue, Iopamiron, Niopam, Solutrast,B-15000,SQ-13396) is a non-ionic, water-soluble radiographic contrast agent. | ||
| S3900 | Betulonic acid | Betulonic acid (Liquidambaric acid), derived from betulinol, a pentacyclic styrene, has shown a highly specific anti-prostate cancer activity in in vitro cell cultures. | ||
| S5378 | Dimethyl phthalate | Dimethyl phthalate is an organic compound, used as an insect repellent for mosquitoes and flies. | ||
| S9133 | Chicoric acid | Chicoric acid (Dicaffeoyltartaric acid), identified in many plants, exerts various properties include anti-cancer, anti-obesity, antiviral, and anti-diabetic effects. | ||
| S9000 | 7,8-Dihydroxy-4-methylcoumarin | 7,8-Dihydroxy-4-methylcoumarin (DHMC) is a precursor in the synthesis of derivatives of 4-methyl coumarin, which has excellent radical scavenging properties. | ||
| S6140 | 16-Dehydroprogesterone | 16-Dehydroprogesterone is a chemical derived from a progesterone. | ||
| S3594 | Adipic acid | Adipic acid (Hexanedioic acid) is an important dicarboxylic acid used for the manufacture of nylon and polyurethane plastics. | ||
| E1264New | VIT-2763 | VIT-2763 is an oral small-molecule inhibitor of ferroportin. It displaces TMR-hepcidin from ferroportin with an IC50 of 24 nM. It also ameliorates anemia, enhances erythropoiesis, and reduces organ iron loading in the Hbbth3/+ β-thalassemia intermedia disease model. | ||
| E1910New | TASIN-30 | TASIN-30 is a selective inhibitor of Emopamil binding protein (EBP) with EC50 values of 0.097 μM for EBP competition, respectively. TASIN-30 displays selectivity for EBP over DHCR24. | ||
| S3902 | Ursonic acid | Ursonic acid (Prunol, Malol, beta-Ursolic acid, NSC4060, CCRIS 7123, TOS-BB-0966), present in many plants, is a pentacyclic triterpenoid that can be used as a cosmetics additive and serve as a starting material for synthesis of more potent bioactive derivatives, such as experimental antitumor agents. | ||
| S5379 | Fenchyl Alcohol | Fenchyl Alcohol is used as a flavoring agent to provide a pine, herbal, lemon, or floral taste to food and drink. | ||
| S9134 | Spinosin | Spinosin (Flavoayamenin), a flavone-C-glycoside, is a bioactive ingredient isolated from a traditional Chinese herb Zizyphi Spinosi Semen. It acts as a plant metabolite and an anxiolytic drug. | ||
| S9001 | Malic acid | Malic acid (Hydroxybutanedioic acid, 2-Hydroxysuccinic acid) is a common, naturally occurring ingredient in many foods. It is the main acid found in apples and other fruits. | ||
| S9484 | Darutoside | Darutoside, derived from botanical extracts, has a powerful regenerating action via decreasing inflammation and restoring collagen. | ||
| S6143 | Ureidopropionic acid | Ureidopropionic acid is an intermediate in the metabolism of uracil. | ||
| S3596 | PVP (Polyvinylpyrrolidone) | PVP (Polyvinylpyrrolidone) is an inert, water-soluble, non-toxic, temperature-resistant, pH-stable, biocompatible, biodegradable polymer that helps to encapsulate and cater both hydrophilic and lipophilic drugs. Polyvinylpyrrolidone has been widely tested and used as an effective wound healing accelerator. | ||
| E4141 | Octadecanedioic acid | Octadecanedioic acid(1,18-Octadecanedioic acid), an endogenous metabolite, is a long-chain dicarboxylic acid. Octadecanedioic acid when mono-conjugated via an ester linkage to paclitaxel exhibits higher maximum tolerated doses and increased efficacy in vivo in multiple subcutaneous murine xenograft models of human cancer. | ||
| E1800New | Oxythiamine chloride hydrochloride | Oxythiamine chloride hydrochloride(Hydroxythiamine chloride hydrochloride) is a salt form of Oxythiamine. It is an inhibitor of transketolase, the enzyme that controls the nonoxidative branch of the pentose phosphate pathway. It also suppresses tumor cell proliferation and promotes apoptosis. | ||
| S9002 | L-Fucose | Fucose (6-Deoxy-L-Galactose, L-fucopyranose) is found on N-linked glycans on the mammalian, insect and plant cell surface. L-Fucose is claimed to have application in cosmetics, pharmaceuticals, and dietary supplements. | ||
| S6144 | O-Acetylserine | O-Acetylserine is an intermediate in the biosynthesis of the common amino acid cysteine in bacteria and plants. | ||
| S3597 | 3-Phenoxybenzoic acid | 3-phenoxybenzoic acid (3-PBA), an intermediate metabolite of pyrethroids, is more toxic than its parent compounds and has been detected in milk, soil, and human urine. | ||
| E4593New | Benzo-15-crown-5 ether | Benzo-15-crown-5-ether (B15C5) is employed as a ligand in metal-catalyzed reactions to improve reactivity and selectivity by coordinating with metal cations. Additionally, it serves as a chelating agent for sodium and potassium ions. | ||
| S4786 | S-Methyl-L-cysteine | S-Methyl-L-cysteine (S-Methylcysteine) is one of the identified number of bioactive substances in garlic that are water soluble that may exert some chemopreventive effects on chemical carcinogenesis. | ||
| S9003 | (R)-(-)-Mandelic acid | (R)-(-)-Mandelic acid is a synthetic intermediate useful for pharmaceutical synthesis. | ||
| S9473 | Nuzhenide | Nuzhenide (Specnuezhenide), a major component of olive seeds, is a member of the class of compounds known as saccharolipids. It has strong antioxidant activity. | ||
| S6146 | Glycoursodeoxycholic acid | Glycoursodeoxycholic acid (Ursodeoxycholyl Glycine, Glycine ursodeoxycholic acid) is an acyl glycine and a bile acid-glycine conjugate. It is a secondary bile acid produced by the action of enzymes existing in the microbial flora of the colonic environment. | ||
| S3598 | Sucrose | Sucrose (D-(+)-Saccharose), a common sugar produced naturally in plants, is a disaccharide, a molecule composed of two monosaccharides:glucose and fructose. | ||
| E2153 | TRYPTAMINE HYDROCHLORIDE | Tryptamine hydrochloride is a derivative of the amino acid tryptophan. Tryptamine hydrochloride is psychoactive and acts as a neurotransmitter in the body, affecting mood, perception and cognition. Tryptamine is synthesized by decarboxylation of L-tryptophan and occurs endogenously at low concentrations in the mammalian brain. In its hydrochloride form, Tryptamine hydrochloride hydrochloride, it is commonly used as a research chemical and as a starting material for the synthesis of other organic compounds. | ||
| E2681 | Sodium acrylate | Sodium acrylate is a metal salt that can be prepared by an acid-base reaction between sodium hydroxide and acrylic acid. | ||
| E1684 | C1632 | C1632 (Lin28-let-7 antagonist 1) is a RNA-binding protein and a potent antagonist of Lin28/pre-let-7 interaction. It inhibits Lin28A binding to pre-let-7a-2, with an IC50 of 8 μM as well as inhibits proliferation in human cancer cells. | ||
| E4594New | Lithium iodide hydrate | Lithium iodide hydrate is a reagent and the water-crystallized form of lithium iodide. It is commonly used as an electrolyte additive in dye-sensitized solar cells and Li-S batteries, enhancing their cycle life. | ||
| S3749 | Calcium gluconate monohydrate | Calcium gluconate (Calcarea gluconica, Calcium gluconate anhydrous, Calcium D-gluconate, Calciofon, Glucobiogen) is element or mineral necessary for normal nerve, muscle, and cardiac function. Calcium as the gluconate salt helps to maintain calcium balance and prevent bone loss when taken orally. | ||
| S3905 | Iso-Steviol | Isosteviol (ISV) is mainly obtained by acid hydrolysis of stevioside, the sweet food additive extracted from the plant Stevia Rebaudiana Bertoni (Bertoni). It possesses various biological activities including anti-hyperglycemic, anti-hypertensive, anti-tumor, anti-inflammatory, and antioxidant effects. | ||
| S6147 | Hexadecanedioic acid | Hexadecanedioic acid (Thapsic acid, Hexadecanedioate, Palmitic acid) is a common saturated fatty acid found in animals, plants and microorganisms. It has antitumor activity. | ||
| S0886 | SC-26196 | SC-26196 is a potent, orally active Delta6 desaturase (D6D, FADS2) inhibitor with an IC50 of 200nM. | ||
| S2971 | SIBA | SIBA (5′-Isobutylthio-5′-deoxyadenosine, 5'-Deoxy-5'-isobutylthioadenosine, 5'-Isobutylthioadenosine) is a synthetic analogue of S-adenosylhomocysteine and is a powerful antipro-liferative drug. SIBA is not only an inhibitor of transmethylation but also interferes with polyamine biosynthesis, probably by blocking aminopropyltransferase. | ||
| S3750 | Sodium benzoate | Sodium benzoate (Benzoic acid sodium salt) is a preservative and uesd as a food additive which is bacteriostatic and fungistatic under acidic conditions. | ||
| S3849 | D-Galactose | D-Galactose (D-Galactopyranose, D-(+)-Galactose) is an aldohexose that occurs naturally in the D-form in lactose, cerebrosides, gangliosides, and mucoproteins and is converted enzymatically into D-glucose for metabolism or polysaccharides for storage. It accelerates senescence in invertebrates and mammals and has been used as a model for aging.D-Galactose can be used to induce animal models of Senescence. | ||
| S4788 | L-α-Phosphatidylcholine | L-α-phosphatidylcholine, a surfactant and a constituent of the liposomal carrier system, has shown hepatoprotection in the various hepatotoxicity model. | ||
| E1536New | (R)-HTS-3 (GLXC-25878) | (R)-HTS-3 (GLXC-25878) is a potent, selective, and cell-active inhibitor of lysophosphatidylcholine acyltransferase 3 (LPCAT3) with an IC50 of 0.09 µM, an enzyme critical for synthesizing C20:4-containing phospholipids. It reduces arachidonic acid-d8 incorporation into phospholipids and mitigates RSL3-induced ferroptosis in HT-1080 and 786-O cancer cells. | ||
| E8033New | DO-264 | DO-264 is a potent, selective, and in vivo-active inhibitor of ABHD12, a lysophospholipid hydrolase enzyme, with an IC50 of 11 nM. It dose-dependently increases levels of lysophosphatidylserine (lyso-PS) and 20:4 phosphatidylserine (20:4 PS) in brain tissue. It also enhances immunological responses in lymphocytic choriomeningitis virus (LCMV) infection. | ||
| S3850 | Glucosamine sulfate | Glucosamine sulfate (D-Glucosaminesulfate, D-Glucosamine sulphate) is a dietary supplement commonly used in the treatment of osteoarthritis. It is a type of glycosaminoglycan, which is a naturally occurring major component of joint cartilage and joint fluid. | ||
| S9139 | 5-Methyl-7-methoxyisoflavone | 5-Methyl-7-methoxyisoflavone is a chemical compound commonly used as a bodybuilding supplement. | ||
| S9014 | AstragalosideⅠ | AstragalosideⅠ, is a bioactive saponin first isolated from the dried plant roots of the genus Astragalus, which is used in traditional Chinese medicine. | ||
| S6152 | Acid Red 27 | Acid Red 27 (Azorubin S, Amaranth) is a modified red azo dye used as a food dye and to color cosmetics. | ||
| S6456 | Glycyrrhetinic acid | Glycyrrhetinic acid is a triterpenoid aglycone component of the natural product glycyrrhizinic acid and possesses remarkable anti-proliferative and apoptosis-inducing activity in various cancer cell lines. | ||
| S2973 | SEC inhibitor KL-1 | SEC inhibitor KL-1 (KL-1) is a potent and selective inhibitor of super elongation complex (SEC) that disrupts the interaction between the SEC scaffolding protein AFF4 and P-TEFb, resulting in impaired release of Pol II from promoter-proximal pause sites and a reduced average rate of processive transcription elongation. KL-1 exhibits an dose-dependent inhibitory effect on AFF4-CCNT1 interaction with Ki of 3.48 μM. | ||
| S6318 | Biotinyl Tyramide | Biotinyl Tyramide is a biotin derivative used for signal amplification in IHC and fluorescent in situ hybridization (ISH). | ||
| E1636 | MV1035 | MV1035, an inhibitor of ALKBH5 significantly reduces GBM U87-MG cell migration and invasiveness through inhibition of the RNA demethylase ALKBH5. | ||
| E1907New | HADA hydrochloride | HADA hydrochloride (HCC-Amino-D-alanine hydrochloride) is a blue fluorescent D-amino acid (FDAA) that labels peptidoglycans in live bacteria without affecting growth and also displays mitochondrial outer membrane permeability. | ||
| S4676 | Gluconolactone | Gluconolactone is a naturally occurring polyhydroxy acid with metal chelating, moisturizing and antioxidant activity. | ||
| S4790 | 3-Hydroxyflavone | 3-Hydroxyflavone (Flavon-3-ol, 3-HF, 3-Hydroxy-2-phenylchromone) is the simplest molecule of the flavonol class that is usually used in synthesis of biologically active molecules. | ||
| S5510 | DMNB | DMNB (4,5-dimethoxy-2-nitrobenzaldehyde) is a volatile organic compound used as a detection taggant for explosives. | ||
| S9390 | Astragaloside II | Astragaloside II, extracted from Astragalus membranaceus, has been reported to promote tissue wound repair and could be a potential adjunctive agent in cancer chemotherapy, enhancement of osteogenesis, and modulation of T cell activation. | ||
| S6460 | Sugammadex (sodium) | Sugammadex (ORG-25969) is a selective relaxant binding agent indicated for reversal of neuromuscular blockade induced by rocuronium bromide and vecuronium bromide during surgery in adults. | ||
| S3415 | AA92593 | AA92593 is a selective antagonist of Melanopsin (OPN4) which is a photo-pigment found in a small subset of intrinsically photosensitive ganglion cells (ipRGCs) of the mammalian retina. | ||
| E0184 | 2-Mercaptobenzothiazole | 2-Mercaptobenzothiazole (Benzothiazole-2-thiol, 2-MBT, Mercapto-2-benzothiazole) is an exceptionally potent inhibitor of banana polyphenoloxidase and can significantly delay the onset of substrate oxidation at concentrations as low as 100 nM. | ||
| E4147 | Indole-3-carboxaldehyde | Indole-3-carboxaldehyde (3-Formylindole), a banlangen extract, is the product of the oxidative degradation of indole-3-acetic acid (IAA) by crude enzyme preparations from etiolated pea seedlings. It is identified as an active principle component in Marinomonas sp., and it efficiently inhibits biofilm formation by Vibrio cholerae O1 (VCO1) without selection pressure. | ||
| S4692 | Succimer | Succimer (DMSA, meso-2,3-dimercaptosuccinic acid) is an orally active metal chelator is used to treat heavy metal poisoning | ||
| S3642 | Cesium chloride | Cesium chloride (CsCl) is the inorganic compound. It is widely used medicine structure in isopycnic centrifugation for separating various types of DNA and is a reagent in analytical chemistry. | ||
| S3852 | L-Theanine | L-Theanine is a relaxing and nondietary amino acid found pretty much exclusively in teas from Camellia sinensis and is known to promote relaxation without sedation. | ||
| S4791 | S-allyl-L-cysteine | S-Allyl cysteine (SAC, S-Allylcysteine), a natural constituent of fresh garlic, has antioxidant and anticancer properties in animals. | ||
| S9143 | Ammonium Glycyrrhizate | Ammonium glycyrrhizate (Glycamil, Glycyrram) is an ammonium salt extract isolated from licorice root and is commonly used as a flavoring agent and is also used in fragrances, and skin and hair care products. | ||
| S9166 | Griffonilide | Griffonilide is a natural product that has been reported to induce bone remodeling activity resulting in structural changes. | ||
| S5853 | 2'-Hydroxy-2-methoxychalcone | 2'-Hydroxy-2-methoxychalcone is a chemical. | ||
| S6463 | Sodium tauroglycocholate | Sodium tauroglycocholate (STGC, Tauroglycocholic acid sodium salt) is an absorption enhancer of transdermal permeation of drug. | ||
| E0185 | Polytetrafluoroethylene | Polytetrafluoroethylene (PTFE) is a biomedical material and has excellent non-stick properties with an exceptionally low coefficient of friction. | ||
| E1074 | MM3122 | MM3122 is a selective inhibitor of host cell serine protease TMPRSS2 (transmembrane protease serine 2) with IC50 of 0.34 nM against recombinant full-length TMPRSS2 protein. | ||
| E1028 | POMHEX | POMHEX, is a potent ENO2 -specific inhibitor of enolase and a racemic mixture, a cell-permeable pivaloyloxymethyl (POM) prodrug of HEX. It is also glycolysis inhibitor and can be used for the research of cancer. | ||
| S5631 | L-Alanine | Alanine is a naturally occuring non-essential amino acid that is involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brainR, and the CNS. | ||
| S9169 | Polygalasaponin F | Polygalasaponin F, a triterpenoid saponin isolated from Polygala japonica, possesses anxiolytic and sedative-hypnotic activities, and has cognition improving and cerebral protective effects. | ||
| S6156 | 5-Methyluridine | 5-Methyluridine (Ribothymidine, Ribosylthymine, Thymine riboside) is a pyrimidine nucleoside that acts as an human endogenous metabolite. | ||
| S3855 | Ethyl ferulate | Ethyl ferulate (Ferulic acid ethyl ester) is the alkyl ester derivative of ferulic acid which is a naturally occurring plant product with anti-oxidative, anti-inflammatory, neuroprotective, and antiproliferative activities. | ||
| S4877 | Eperisone hydrochloride | Eperisone hydrochloride is muscle relaxant agent with antispasmodic effects. It is widely used in the treatment of patients with muscular contractures, low back pain or spasticity. | ||
| S5632 | L-aspartic Acid | L-aspartic Acid is one of non-essential amino acids and may be a neurotransmitter. | ||
| S6157 | Benzyldimethylstearylammonium Chloride Hydrate | Benzyldimethylstearylammonium Chloride Hydrate is a chemical with mild odor. | ||
| S4438 | Benzophenone | Benzophenone (Diphenyl ketone, Benzoylbenzene) filters out both UVA and UVB rays and is widely used in a great variety of sunscreens and personal care products. | ||
| E1037 | ZZW-115 | ZZW-115 is a potent NUPR1 inhibitor with IC50s of 0.42 μM in Hep2G cells and 7.75 μM in SaOS-2 cells. ZZW-115 shows evident antitumor activity through its interaction with NUPR1. | ||
| S3856 | Allantoin | Allantoin (Glyoxyldiureide, 5-Ureidohydantoin), produced from uric acid, is a major metabolic intermediate in most organisms including animals, plants and bacteria. | ||
| S5434 | AS057278 | AS057278 (3-Methylpyrazole-5-carboxylic acid, MPC) is an inhibitor of D-amino acid oxidase (DAAO). | ||
| S5629 | L-Proline | L-Proline is one of non-essential amino acids and an essential component of collagen that is important for proper functioning of joints and tendons. | ||
| S9479 | Complanatoside A | Complanatoside A is a flavonol glycoside isolated from Astragalus complanatus and is used as a quality control index for A. complanatus in the 2010 edition of the Chinese Pharmacopoeia. | ||
| S6158 | Acid orange 7 | Acid orange 7 (2-naphthol orange, Orange II, CI 15510, D&C Orange 4, COLIPA C015) is an azo dye used for dyeing wool. | ||
| E4941New | Diflorasone diacetate | Diflorasone diacetate(Florone), is a steroid anti-inflammatory drug, an inhibitor of TARC (thymus and activation regulated chemokine; CCL17) in the dinitrochlorobenzene (DNCB) model. It can be used in the treatment of allergic and inflammatory skin diseases such as atopic dermatitis and allergic contact dermatitis. | ||
| S5630 | L-lysine | Lysine is an α-amino acid that is used in the biosynthesis of proteins and is required for growth and tissue repair. | ||
| S6159 | Food Yellow 3 | Food Yellow 3 (Sunset yellow) is an azo dye that is useful in fermented foods which must be heat treated. | ||
| E4407 | Thiobarbituric acid | Thiobarbituric acid (2-Thiobarbituric acid) is a colorimetric reagent commonly used in the detection of malondialdehyde (MDA), a marker of lipid peroxidation. | ||
| E4932New | Amikacin | Amikacin(BAY 41-6551, Lukadin) is a semisynthetic aminoglycoside, derived from kanamycin-A, that acts as an inhibitor of the Z ring formation, leading to the inhibition of cell division. It is used to treat serious infections caused by aerobic Gram-negative bacteria, mycobacteria, Nocardia, and life-threatening infections in neonates. | ||
| S2353 | Sapogenins Glycosides | Sapogenins glycosides (Saponins) are a mixture of triterpene and steroid saponins isolated from medicinal plants such as Aesculus hippocastanum L., Hedera helix L. and Ruscus aculeatus L., which are claimed to be effective for the treatment/prevention of venous insufficiency. | ||
| S3858 | Lawsone | Lawsone (Hennotannic acid, 2-hydroxy-1,4-naphthoquinone) is a red-orange dye present in the leaves of the henna plant (Lawsonia inermis) as well as in the flower of water hyacinth (Eichhornia crassipes). | ||
| S9259 | Lithospermic acid | Lithospermic acid, an active component isolated from Salvia miltiorrhiza radix, is known to have multiple pharmacological actions such as antihypertensive and antioxidant effects. | ||
| S9491 | (+)-Guaiacin | (+)-Guaiacin, found in herbs and spices, belongs to the class of organic compounds known as aryltetralin lignans. | ||
| S6160 | 3,5-Dihydroxybenzoic acid | 3,5-Dihydroxybenzoic acid (α-resorcylic acid) is a primary metabolite of alkylresinols which has been hydrolyzed by liver enzymes during phase I metabolism after several cycles of beta oxidation. | ||
| S2587 | Sodium Glucoheptonate Dihydrate | Sodium glucoheptonate is used for cleaning metal, mercerizing, paint stripping, and aluminum etching. | ||
| S0857 | BLT-1 | BLT-1(Block lipid transport-1), a thiosemicarbazone copper chelator, is a selective inhibitor of HDL receptor (scavenger receptor B, type 1 - SR-BI). BLT-1 inhibits the transfer of lipids between HDL and cells mediated by SR-BI. | ||
| S3859 | Vanillyl Alcohol | Vanillyl alcohol (4-Hydroxy-3-methoxybenzyl alcohol, Vanillin alcohol, Vanillic alcohol, 3-Methoxy-4-hydroxybenzyl alcohol), derived from vanillin, is used to flavor food. | ||
| S5133 | Sodium erythorbate | Sodium erythorbate (NaE, D-Isoascorbate, Erythorbic acid sodium salt, Araboascorbic acid monosodium salt, Erbit N, Eribate N, Isoascorbate C sodium) is the sodium of erythorbic acid, a highly refined food-grade chemical closely related to vitamin C, synthesized from sugar, and used as a color fixative in preparing cured meats. | ||
| S5618 | Hippuric acid | Hippuric Acid (2-Benzamidoacetic acid, Benzoylglycine) is an acyl glycine produced by the conjugation of benzoic acid and glycine, found as a normal component in urine as a metabolite of aromatic compounds from food. | ||
| S6163 | Traumatic acid | Traumatic acid (Trans-2-dodecenedioic acid) is a plant hormone that was first isolated from damaged green beans. It is a potent wound healing agent and an intermediate in prostaglandin synthesis. | ||
| S6712 | S107 | S107 is a Type 1 ryanodine receptor (RyR1) stabilizer that binds RyR1 and enhances the binding affinity of calstabin-1. | ||
| S4442 | Neotame | Neotame is a low-caloric and high-intensity artificial sweetener that reduces the alpha-diversity and altered the beta-diversity of the gut microbiome. | ||
| S9925 | Imeglimin (EMD 387008) Hydrochloride | Imeglimin (EMD 387008, IMEG, PXL 008, RVT-1501) Hydrochloride is a new class of oral glucose-lowering agents. Imeglimin normalizes glucose tolerance and insulin sensitivity by preserving mitochondrial function from oxidative stress and favoring lipid oxidation in liver of HFHSD mice. | ||
| S5216 | Carbocisteine | Carbocisteine (S-carboxymethyl-l-cysteine) is a very important pharmaceutical product with mucolitic activity and is normally used for the treatment of bronchitis and colds. | ||
| S5635 | L-cysteine | Cysteine is a naturally occurring, sulfur-containing amino acid which is important for protein synthesis, detoxification, and also exerts diverse metabolic functions. | ||
| S6801 | AKOS B018304 | AKOS B018304 (C6;NSC 43396) is an arylalkylidene derivative with a polar substitution at the para-position. It functions as an inhibitor of ΔFosB by allosterically inhibiting its binding to DNA. It disrupts ΔFosB binding to TMR-cdk5 with an IC50 value of 10.1 μM and also induces a structural change in ΔFosB that prevents the protein from binding to DNA. | ||
| E2808 | WAY-296817 | WAY-296817 is a bioactive compound. | ||
| S3862 | Gallic acid trimethyl ether | Gallic acid trimethyl ether (Eudesmic acid, Tri-O-methylgallic acid, Benzoic acid, 3,4,5-Trimethoxybenzoic acid) is an O-methylated trihydroxybenzoic acid that is found in olive. | ||
| S9152 | Epiberberine | Epiberberine, a natural protoberberine alkaloid, is a potent inhibitor against both ureases with IC50 values of 3.0±0.01μM for HPU (ureases from Helicobacter pylori) and 2.3±0.01μM for JBU (ureases from jack bean). | ||
| S6168 | trans-trans-Muconic acid | trans-trans-Muconic acid is a metabolite of benzene in humans. | ||
| S4444 | Hypromellose | Hypromellose (Hydroxypropyl Methyl Cellulose, HPMC, Celacol HPM 5000) is a commonly employed cellulose ether used in the fabrication of hydrophilic matrices. Hypromellose provides the release of a drug in a controlled manner, effectively increasing the duration of release of a drug to prolong its therapeutic effect. | ||
| E0210 | Quercetin 3-O-β-D-glucuronide | Quercetin 3-O-β-D-glucuronide (Miquelianin, Q3GA) is one of the quercetin metabolites with antioxidant activity. | ||
| E2227 | GLN-1062 | GLN-1062 (Memogain) is an inactive pro-drug of galantamine, the latter being a plant alkaloid approved for the treatment of mild to moderate Alzheimer's disease. | ||
| E4666New | O-Propargyl-Puromycin | O-Propargyl-Puromycin (OP-puro) is an alkyne puroanalog, a potent inhibitor of protein synthesis . It is used to label nascent proteins in whole animals, allowing the visualization of protein synthesis patterns in large explants from tissues and organs. | ||
| S3863 | Methyl EudesMate | Methyl EudesMate (Methyl tri-O-methylgallate) is the methyl ester of 3,4.5-trimethoxybenzoic acid that used as an intermediate in the synthesis of pharmaceuticals. | ||
| S5628 | L-Valine | Valine is a branched-chain essential amino acid that has stimulant activity and promotes muscle growth and tissue repair. It is a precursor in the penicillin biosynthetic pathway. | ||
| S9153 | Betulinicaldehyde | Betulinicaldehyde (Betulinal, Betunal), isolated from the bark of tectona grandis., is an anti-tumor agent. | ||
| S6169 | 3-Methyladipic acid | 3-Methyladipic acid is a metabolite of the catabolism of phytanic acid. | ||
| S1846 | Hydroxy-PEG4-O-Boc | Hydroxy-PEG4-O-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. | ||
| E2815 | Lalistat 2 | Lalistat 2 is a specific inhibitor of lysosomal acid lipase (LAL) which allows the determination of LAL in dried blood spots (DBS). | ||
| S2355 | Sclareolide | Sclareolide (Norambreinolide) is a sesquiterpene lactone natural product derived from various plant sources including Salvia sclarea, Salvia yosgadensis, and cigar tobacco. | ||
| S3864 | Dulcitol | Dulcitol (Galactitol, D-Galactitol, Dulcose) is a naturally occurring product of plants obtained following reduction of galactose. | ||
| S9395 | N-Benzoyl-(2R,3S)-3-phenylisoserine | N-Benzoyl-(2R,3S)-3-phenylisoserine, also known as taxol side chain, is important for strong antitumor activity of taxol. | ||
| S6170 | Benzyldodecyldimethylammonium Chloride Dihydrate | Benzyldodecyldimethylammonium Chloride Dihydrate is a chemical. | ||
| S6340 | Guanidinoacetic acid | Guanidinoacetic acid (Guanidino acetic acid, GAA, Glycocyamine, Guanidinoacetate), the natural precursor of creatine, is under investigation as a dietary agent. Guanidinoacetic acid exhibits potential ergogenic benefits for physically active men and women. | ||
| E2950 | Fat Emulsion（20%） | Fat Emulsion（20%）is a safe fat emulsion that can be used as a nutritional supplement. Fat Emulsion（20%）inhibits the opening of the mitochondrial permeability transition pore and effectively protecting the heart from ischaemia-reperfusion injury. It has some potential to modulate the innate immune response. | ||
| S9155 | Aurantio-obtusin | Aurantio-obtusin is a natural effective compound isolated from Semen Cassiae, which possesses hypotensive and hypolipidemic effects. | ||
| S9399 | 1,2,3,4,6-O-Pentagalloylglucose | 1,2,3,4,6-O-Pentagalloylglucose is the pentagallic acid ester of glucose. It could be used for precipitating proteins. | ||
| S6171 | trans-β-Hydromuconic acid | trans-β-Hydromuconic acid (trans-2-Butene-1,4-dicarboxylic Acid, 3-hexenediodicacid, β-Hydromuconic acid) is a normal human unsaturated dicarboxylic acid metabolite with increased excretion in patients with Dicarboxylic aciduria caused by fatty acid metabolism disorders. | ||
| S4621 | Tween-20 | Tween-20 (Polysorbates 20) is used in the formulation of biotherapeutic products for both preventing surface adsorption and as a stabilizer against protein aggregation. | ||
| E1217 | PCLX-001 (DDD86481) | PCLX-001 (DDD86481) is an orally active dual N-myristoyltransferase (NMT) inhibitor. It inhibits NMT1 and NMT2 with IC50 of 5 nM and 8 nM, respectively, in vitro. PCLX-001 inhibits early B-cell receptor (BCR) signalling, which can be used in B-cell malignancy research. | ||
| E1538 | PRGL493 | PRGL493 is a potent and selective inhibitor of long-chain acyl-CoA synthetase 4 (ACSL4). PRGL493 blocks cell proliferation and tumor growth in both breast and prostate cellular and animal models. PRGL493 is used for cancer research. | ||
| S2356 | Shikimic Acid | Shikimic acid (Shikimate), more commonly known as its anionic form shikimate, is an important biochemical intermediate in plants and microorganisms. | ||
| S5460 | Vitexin-2-O-rhaMnoside | Vitexin-2-O-rhamnoside (2''-O-Rhamnosylvitexin, Apigenin-8-C-glucoside) is one of the main components of flavonoid of the leaves of Crataegus pinnatifida Bge. var major N. E. Br. It has many biological and pharmacological activities, such as antioxidation and treating heart disease. | ||
| S9476 | Dendrobine | Dendrobine, a plant alkaloid isolated from Dendrobium nobile, has been used for the quality control and discrimination of Dendrobium. | ||
| E1080 | HG106 | HG106, a potent SLC7A11 inhibitor, leads to enhanced ROS generation, ER stress, and ultimately growth arrest specifically in KRAS-mutant lung adenocarcinoma (LUAD). | ||
| E2969 | Mannan | Mannan is one of the major components of the yeast cell wall. It can be used to coat the microtiter wells to quantify the levels of mannose-binding lectin (MBL) using a mannan-binding enzyme-linked immunosorbent assay (ELISA). Mannan exhibits antiproliferative, antioxidant, and immunomodulatory properties. | ||
| S4388 | Bentiromide | Bentiromide is a peptide which is broken down in the pancreas by chymotrypsin. The bentiromide test is a test of pancreatic exocrine function. | ||
| S5468 | Kaempferol-3-O-glucorhamnoside | Kaempferol 3-neohesperidoside (Kaempferol 3-neohesperidoside), isolated from the herbs of Delphinium grandiflorum L., has insulin-like properties in terms of glucose lowering. | ||
| S9448 | D-(+)-Turanose | D(+)-Turanose is a naturally occuring compound. It is a reducing disaccharide. | ||
| S9481 | Blinin | Blinin, isolated from the whole plant of Conyza blinii, is used in folk medicine in the south-west of China. | ||
| S6175 | 1,5,5-Trimethylhydantoin | 1,5,5-Trimethylhydantoin is a chemical. | ||
| E4416 | Stearamide | Stearamide is a a primary fatty acid amide that displays cytotoxic and ichthytoxic activity. Stearamide is also used as a lubricating agent in the polymer industry. | ||
| S4520 | 2-Aminoheptane | 2-Aminoheptane (Tuaminoheptanez, Tuamine, Heptamine, 1-Methylhexylamine, 2-Heptylamine) is a nasal decongestant drug which is a sympathomimetic stimulant and vasoconstrictor. | ||
| S9482 | 2-methoxycinnamaldehyde | 2-methoxycinnamaldehyde (O-methoxycinnamaldehyde), found in ceylan cinnamon, is a flavouring ingredient. | ||
| S6178 | DL-6,8-Thioctamide | DL-6,8-Thioctamide (alpha-Lipoic amide) is used for protecting liver and health care products. | ||
| S6479 | Isohomovanillic acid | Isohomovanillic acid is a deaminated metabolite of catecholamines formed by the enzyme catechol-O-methyltransferase which catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. | ||
| S3976 | Acetylvanillin | Acetylvanillin (Acetovanillin, Vanillin acetate, 4-Acetoxy-3-methoxybenzaldehyde, 4-Formyl-2-methoxyphenyl acetate) is found in pulses and is a flavouring material. | ||
| S9160 | Ziyu-glycoside I | Ziyuglycoside I is one of the major active ingredients in Sanguisorba officinalis and could be used as an active ingredient for cosmetics. | ||
| S9485 | Waltonitone | Waltonitone, an ursane-type pentacyclic triterpene extracted from Gentiana waltonii Burkill, exerts anti-tumor effect. | ||
| S6180 | L-Gulose | L-Gulose is an unnatural monosaccharide that exists as a syrup with a sweet taste. It is an L-hexose sugar and an intermediate in the biosynthesis of L-Ascorbate (vitamin C). | ||
| S6480 | Triphosphopyridine nucleotide disodium salt | Triphosphopyridine nucleotide (NADP) serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). | ||
| E1708 | Solutol HS-15 | Solutol HS-15(Polyethylene glycol 12-hydroxystearate) is a Macrogol 15 hydroxy stearate, which improves permeability by disrupting the membrane structure/fluidity change. Note: Due to its chemical properties, this product will be semi-solid and solid at room temperature and low temperature. | ||
| S7814 | AI-10-49 | AI-10-49 is a selective inhibitor of the binding of CBFβ-SMMHC to RUNX1 with IC50 of 260 nM. | ||
| S5745 | Glyceryl 1,3-dipalmitate | Glyceryl 1,3-dipalmitate acts as a metabolite of saccharomyces cerevisiae, plant and human. | ||
| S6181 | N-Isovaleroylglycine | N-Isovaleroylglycine is an acyl glycine that is normally minor metabolites of fatty acids. | ||
| S6481 | 3beta-hydroxy-delta5-cholenic acid | 3beta-hydroxy-delta5-cholenic acid is a monohydroxy bile acid of endogenous origin. It is found in biologic fluids beginning in fetal life. | ||
| E4001 | Sodium pyrophosphate decahydrate | Sodium pyrophosphate decahydrate acts as a buffering agent, a chelator and a hydrated salt nucleating agent. Sodium pyrophosphate decahydrate can also be used to a raw material for synthetic laundry scent additives. | ||
| S4534 | 6-Acetamidohexanoic acid | 6-Acetamidohexanoic acid (6-Acetamidocaproic acid) is a pharmaceutical intermediate. | ||
| S5746 | pentetate calcium trisodium hydrate | pentetate calcium trisodium hydrate (Ca-DTPA) is an iron chelating agent. | ||
| S9494 | Darutigenol | Darutigenol has antithrombotic effect and may be related to inhibition of platelet aggregation and adhesion. | ||
| S6182 | L-Gulono-1,4-lactone | L-Gulono-1,4-lactone (L-Gulonolactone, L-Gulono-gamma-lactone, reduced ascorbic acid) is the substrate of the enzyme L-gulono-1,4-lactone oxidoreductase, which catalyzes the last step of the biosynthesis of L-ascorbic acid (vitamin C) in plants and animals. | ||
| E4420 | NADP sodium salt | NADP sodium salt, a nicotinamide adenine dinucleotide, is a coenzyme that plays a vital role in various metabolic reactions within living cells. NADP sodium salt is a key cofactor for electron transfer in the metabolism, being alternately oxidized (NADP+) and reduced (NADPH). | ||
| S5305 | Bromisoval | Bromisoval (Bromovalerylurea, Isobromyl, Bromaral, BRN 1773255) is a hypnotic and sedative of the bromoureide group with anti-inflammatory effects. | ||
| S5547 | Hydroxylammonium chloride | Hydroxylammonium chloride (Hydroxylamine hydrochloride) is the hydrochloric acid salt of hydroxylamine, which is a biological intermediate in the nitrification and in the anammox. | ||
| S6183 | 2-Hydroxy-2-methylbutanoic acid | 2-Hydroxy-2-methylbutyric acid is an unusual metabolite found in the urine of patients with 2-hydroxyglutaric aciduria and maple syrup urine disease. 2-Hydroxy-2-methylbutyric acid is also a secondary metabolite found in human urine after exposure to the gasoline additive tert-amyl-Me-ether (TAME). | ||
| S6483 | O-Phosphoethanolamine | Phosphoethanolamine (PE) is a phosphomonoester metabolite of the phospholipid metabolism. | ||
| E2998 | Acetylthiocholine iodide | Acetylthiocholine iodide(S-Acetylthiocholine iodide; ATCh iodide) is used as a substrate in the preparation of acetylcholine esterase (AChE) assay working solution for AChE activity assay. In addition, the compound is used in some medical research, for example in the fields of neuroscience and organ physiology. | ||
| E4958New | cis-Bac430 | Cis-Bac430 plays a role in mediating the movement of anti-tumor CD8+cells from the periphery to the tumor site,thus enhancing the anti-tumor effect of an immune checkpoint inhibitor. | ||
| S4826 | Aluminium hydroxide | Aluminium hydroxide (Aluminic), found in nature as the mineral gibbsite, is amphoteric (i.e., it has both basic and acidic properties). It is used to treat symptoms of increased stomach acid, such as heartburn, upset stomach, sour stomach, or acid indigestion; also reduce phosphate levels in people with certain kidney conditions. | ||
| S5530 | Geraniol | Geraniol is a terpene alcohol occurring in the essential oils of several aromatic plants used in the flavour and fragrance industries. It also exhibits insecticidal and repellent properties and used as a natural pest control agent exhibiting low toxicity. | ||
| S9164 | Curdione | Curdione, one of the major components of Curcuma zedoaria, shows an excellent antithrombotic activity in vivo. | ||
| S6184 | N-Methylhydantoin | N-Methylhydantoin (1-Methylhydantoin, Dioxy-creatinine) is a small molecular weight polar substance, the product of degradation of creatinine by bacteria. It is an unexpected metabolite of the intelligence-affecting substance dupracetam. | ||
| S6428 | Wilforlide A | Wilforlide A is an active compound in Tripterygium wilfordii Hook F (TW) which is a traditional Chinese medicine for treatment of autoimmune diseases. | ||
| S3281 | Quercetin 3-O-β-D-glucose-7-O-β-D-gentiobioside | Quercetin 3-O-β-D-glucose-7-O-β-D-gentiobioside (Quercetin 3-O-β-D-glucose-7-O-β-D-gentiobiosiden, Quercetin-3-O-beta-D-glucose-7-O-beta-D-gentiobioside) is an active constituent of Descurainiae Semen. | ||
| E1275 | FR054 | FR054 is a novel inhibitor of the Hexosamine Biosynthetic Pathway (HBP) enzyme PGM3 with a remarkable anti-breast cancer effect. | ||
| E2997 | (+)-Biotin N-hydroxysuccinimide ester | (+)-Biotin N-hydroxysuccinimide ester(Biotin-NHS; NHS-Biotin) is an amino reactive biotin reagent used in the preparation of biotinylated surfaces or polypeptides. | ||
| E1620 | Fluorofurimazine | Fluorofurimazine is a novel furimazine analogue, with increased aqueous solubility enabling higher signal emission than furimazine for bioluminescence imaging. Fluorofurimazine enables higher substrate loading and improved optical imaging sensitivity in in-vivo. | ||
| S1711 | Crotamiton | Crotamiton is a drug that is used as a scabicidal (for treating scabies) and an antipruritic | ||
| S3908 | 4'-Demethylpodophyllotoxin | 4'-Demethylpodophyllotoxin is isolated from the herb of Dysosma pleiantha (Hance) Woodson with remarkable cytotoxic potential in diverse cancer cell lines. | ||
| S5636 | Methyl furan-2-carboxylate | Methyl furan-2-carboxylate (Methyl pyromucate, Methyl 2-furoate) is found in cocoa and cocoa products. It is used in food flavouring and preparation of sesquiterpene lactone. | ||
| S9557 | Isobergapten | Isobergapten is a furanocoumarin with plant growth regulating activity. | ||
| S6188 | p-Toluenesulfonic acid monohydrate | p-Toluenesulfonic acid (4-Methylbenzenesulfonic acid, Tosylic acid, tosic acid, para-toluene) is an extremely strong acidic compound. | ||
| S1872 | Amino-PEG1-C2-acid | Amino-PEG1-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. | ||
| S4492 | Dextran | Dextran (Dextran 40, Macrodex) is a kind of biocompatible, nontoxic and nonimmunogenic biological substance that has been widely used in drug-delivery systems. | ||
| E2999 | Dimethyl pimelimidate dihydrochloride | Dimethyl pimelimidate dihydrochloride (DMP) is a homobifunctional amine-reactive crosslinker which is readily hydrolyzed at neutral pH. | ||
| E7195New | N-Acetyl-D-cysteine | N-Acetyl-D-cysteine is a derivative of cysteine with antioxidant properties. It shares some properties with N-acetyl-L-cysteine, such as ROS scavenging due to its thiol group, but it cannot participate in glutathione biosynthesis. | ||
| S3909 | Catalpol | Catalpol (Catalpinoside, Digitalis purpurea L), an iridoid glucoside contained richly in the roots of the small flowering plant species Rehmannia glutinosa Libosch, has been shown to have antioxidation, anti-inflammation, anti-apoptosis and other neuroprotective properties and plays a role in neuroprotection against hypoxic/ischemic injury, AD and PD in both in vivo and in vitro models. | ||
| S6189 | Acid Yellow 36 | Acid Yellow 36 (Metanil Yellow) is a dye of the azo class and used as a pH indicator and it has a color change from red to yellow between pH 1.2 and 2.3. | ||
| S3302 | β,β-dimethyl-acryl-alkannin | β,β-dimethyl-acryl-alkannin (AN-I, β,β-Dimethylacrylalkannin) is a napthoquinone isolated from roots of Arnebia nobilis Reichb.f. that has the potential to be used as an anti-aging ingredient. | ||
| E0147 | Simethicone | Simethicone (Simeticone) is a nonabsorbable, surface-active, antifoaming agent. | ||
| S4551 | Bisoctrizole | Bisoctrizole (Tinosorb M, Tinuvin-360, UV-360, Milestab-360) is a broad-spectrum ultraviolet radiation absorber, absorbing UVB as well as UVA rays. Also a hybrid UV absorber, reflecting and scattering UV. | ||
| S5363 | Pikamilone | Pikamilone is a drug having a central (vegetotropic and vascular) and peripheral (vasodilating) mechanisms of action. | ||
| S9168 | Periplogenin | Periplogenin (Desoxostrophanthidin, 5-beta-Hydroxydigitoxigenin), isolated from Lagenaria siceraria, has potent anti-psoriatic effects in vitro and in vivo. | ||
| S6190 | Isethionic acid sodium salt | Isethionic acid sodium salt is an amphoteric detergent used in detergent bar soaps. | ||
| S9848 | LM11A-31 | LM11A-31 is a small molecule p75NTR Ligand that reverses cholinergic neurite dystrophy in alzheimer's diseasemousemodels with mid- to late-stage disease progression. | ||
| E0191 | DL-α-tocopherol acetate | DL-α-Tocopherol acetate (DL-Alpha-tocopherol acetate , Vitamin E acetate), a vitamin E derivative, is used as a vitamin E supplement in poultry feeds. | ||
| E0514 | Flugestone 17-acetate | Flugestone 17-acetate (Flurogestone acetate) is a corticosteroid hormone. | ||
| E1245 | Ro5-3335 | Ro5-3335 is an inhibitor of Core binding factor leukemia (CBF leukemia), by interacting with RUNX1 and CBFβ directly, repressing RUNX1/CBFB-dependent transactivation and runx1-dependent hematopoiesis. | ||
| E4003 | N,N'-Methylenebisacrylamide | N,N'-Methylenebisacrylamide(Methylenebisacrylamide) is a biochemical,cross-linking agent reagent that can be used as a biological material, during the formation of polymers or organic compound for life science related research. | ||
| S3306 | 1,1,1,1-Kestohexaose | 1,1,1,1-Kestohexaose is a major DP 6 fructan in crested wheatgrass leaves. | ||
| E2695 | FITC-Dextran (MW 10000) | FITC-Dextran(MW 10000) are polysaccharides comprised of varying lengths of branched glucose molecules and can be used to determine solute, ion and protein permeability of the blood-brain barrier (BBB) based on the size of the dextran used. | ||
| E4004 | DL-beta-Hydroxybutyric acid sodium salt | DL-beta-Hydroxybutyric acid sodium salt(β-Hydroxybutyric acid sodium) is a metabolite that is elevated in type I diabetes. It can modulate the properties of membrane lipids. | ||
| S6194 | Chitin | Chitin is a large, structural polysaccharide found in the exoskeletons of insects, the cell walls of fungi, and certain hard structures in invertebrates and fish. | ||
| S6775 | TUG-891 | TUG-891 is a potent and selective agonist of the long chain free fatty acid (LCFA) receptor 4 (FFA4/GPR120), which demonstrates both potential opportunity and possible challenges to therapeutic agonism. | ||
| S9943 | ErSO | ErSO activates the unfolded protein response (UPR) with an IC50 of 20.3 nM in MCF-7 cells. ErSO induces rapid and selective necrosis of ERα-positive breast cancer cell lines in vitro. | ||
| A2042 | Pamrevlumab (anti-CTGF) | Pamrevlumab, a recombinant human antibody that binds to connective tissue growth factor (CTGF) has emerged as a potential therapy for idiopathic pulmonary fibrosis (IPF). |
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| E1292 | 4-Thiouridine | 4-thiouridine (4-Thio-UTP), a thiouridine and a nucleoside analogue, has a role as an affinity label and an antimetabolite. | ||
| E4005 | Decamethylcyclopentasiloxane | Decamethylcyclopentasiloxane(Cyclomethicone 5) is an organosilicon compound. It is used in cosmetic and personal products as a skin emollient. | ||
| S4554 | Bucetin | Bucetin is an analgesic and antipyretice agent with a risk of carcinogenesis. | ||
| S5643 | 1,2-dipalmitoyl-sn-glycero-3-phosphocholine | 1,2-dipalmitoyl-sn-glycero-3-phosphocholine is a zwitterionic phosphoglyceride that can be used for the preparation of liposomal monolayers. | ||
| S6482 | Fosphenytoin (disodium) | Fosphenytoin (disodium) is the sodium salt form of fosphenytoin, a prodrug that is hydrolyzed to the anticonvulsant phenytoin upon parental administration. | ||
| E2694 | D-Saccharic acid 1,4-lactone monohydrate | D-Saccharic acid 1,4-lactone monohydrate is a potent β-glucuronidase inhibitor with an IC50 of 48.4 μM. | ||
| E4010 | L-3,4-Dihydroxyphenylalanine methyl ester hydrochloride | L-3,4-Dihydroxyphenylalanine methyl ester hydrochloride(Melevodopa hydrochloride) is a precursor to L-DOPA. It is an antiparkinsonian agent L-DOPA methyl ester that elicits antitumor functionality in leukemia and melanoma. | ||
| A4061New | Emicizumab (Anti-Factor IX & Factor X) | Emicizumab is a recombinant, humanized, bispecific antibody that binds Factor IXa and Factor X to mimic Factor VIII function. It is used to treat hemophilia A. M.W 146.82 kDa | ||
| S5084 | Carbazochrome | Carbazochrome (Adedolon, Adchnon, Adrenostazin, Cromadrenal, Adona, AC-17) is a hemostatic agent that causes the aggregation and adhesion of platelets in the blood to form a platelet plug, ceasing blood flow from an open wound. | ||
| S9173 | Sec-O-Glucosylhamaudol | Sec-O-Glucosylhamaudol (Hamaudol 3-glucoside) is one of the major bioactive compounds of the Saposhnikoviae Radix. | ||
| E4012 | 4-Methylumbelliferyl beta-D-glucopyranoside | 4-Methylumbelliferyl beta-D-glucopyranoside(MUD) is a β-D-glucoside, is a fluorogenic substrate for β-glucosidase. It is utilized in the assay of beta-glucosidase activity. | ||
| E1723 | NSC16168 | NSC16168 is a specific inhibitor of ERCC1-XPF, and exhibits an IC50 value of 0.42 μM in a high throughput screen (HTS) assay, respectively. NSC16168 inhibits DNA repair and potentiates cisplatin efficacy in cancer. | ||
| E4785New | BAP1-IN-1 | BAP1-IN-1 is a small-molecule inhibitor of BRCA1 associated protein 1 (BAP1) catalytic activity in vitro with an IC50 of 0.1-1 μM. It exhibits a potential therapeutic target for leukemia. | ||
| E7200New | Ceramides Mixture | Ceramides Mixture are endogenous long chain, bioactive lipids forming the hydrophobic backbone of complex sphingolipids and are major constituents of the stratum corneum, contributing to the skin's permeability barrier. They regulate key biological processes such as growth inhibition, cell cycle arrest, telomerase activity modulation, proliferation, apoptosis, and senescence. | ||
| S4402 | Oxeladin Citrate | Oxeladin citrate (OL), a cough suppressant, is a highly potent and effective drug applied in the treatment of all types of cough of various etiologies. | ||
| S4556 | Carzenide | Carzenide (4-Sulfamoylbenzoic acid) is an organic synthesis intermediate, used for synthetic drug. | ||
| S5521 | Eosin Y Disodium | Eosin Y is a form of eosin. It is most commonly used as an acidic red stain for highlighting cytoplasm material in samples. | ||
| S6202 | Butylated hydroxytoluene | Butylated hydroxytoluene (dibutylhydroxytoluene, Dibutylated hydroxytoluene, AO-29, BHT) is a lipophilic organic compound that is useful for its antioxidant properties. | ||
| D4054 | Glembatumumab vedotin | Glembatumumab vedotin (CDX-011 (DOX), CR011,CR011-vcMMAE) is an antibody-drug conjugate (ADC) composed of an fully human IgG2 monoclonal antibody (CR011) directed against glycoprotein NMB (GPNMB), conjugated to Monomethyl Auristatin E (MMAE), via a cleavable maleimidocaproyl-valyl-citrullinyl-p-aminobenzyloxycarbonyl (mc-val-cit-PABC) type linker. Glembatumumab vedotin has the potential for use in research of Breast cancer (TNBC) and advanced or metastatic melanoma. | ||
| E4175 | (±)-Naringenin | (±)-Naringenin is a naturally occurring flavonoid. (±)-Naringenin displays a vasorelaxant effect on endothelium-denuded vessels via activating BKCa channels in myocytes. | ||
| S2036 | Aspartame | Aspartame (SC-18862,Nutrasweet) is an artificial, non-saccharide sweetener used as a sugar substitute in some foods and beverages. | ||
| S4808 | L-Cystine | L-Cystine is the oxidized dimer form of the amino acid L-cysteine which is a non-essential amino acid of the human body. It is required for wound healing and formation of epithelial tissue. | ||
| S4927 | Cyclen | Cyclen (1,4,7,10-tetraazacyclododecane) is a macrocycle capable of selectively binding cations that used as a ligand in chemistry for instance with chemicals used in MRI contrast agents. | ||
| S6484 | uridine triacetate | Uridine triacetate (Vistonuridine, PN401) is an orally active prodrug of the naturally occurring nucleoside uridine. It is used for the treatment of hereditary orotic aciduria (Xuriden), or for the emergency treatment of fluorouracil or capecitabine overdose or toxicity. | ||
| S3247 | Icariside I | Icariside I (Icarisid I) is one of the main components in Epimedii Folium that significantly stimulates cell proliferation and osteoblasts differentiation. | ||
| E4008 | Safranin O | Safranin O(Safranin T) is an important and classical phenazinium dye. It has been extensively used in the academic field as a spectroscopic probe and indicator. It can be used as a redox indicator in the determination of metal ion concentration. | ||
| E4816New | Choline hydroxide, 42.5 wt.% in water | Choline hydroxide, 42.5 wt.% in water, is a strong organic base used as a metal-free, nontoxic, and water-soluble catalyst. It facilitates the synthesis of 1,8-naphthyridine derivatives while avoiding the use of hazardous or carcinogenic organic solvents. | ||
| E5773New | Gypenoside L | Gypenoside L, is a saponin from Gynostemma pentaphyllum, increases SA-β-galactosidase activity, enhances senescence-associated cytokine production, inhibits proliferation and LPS-induced nitric oxide (NO) production, induces S-phase arrest, and activates p21, p27, p38, ERK MAPK, and NF-κB pathways to promote senescence. | ||
| S4558 | Citiolone | Citiolone is a derivative of the amino acid cysteine, used in liver therapy. | ||
| S4810 | Glycylglycine | Glycylglycine (Diglycine, Diglycocoll, Glycine dipeptide), the simplest peptide made of two glycine molecules, is usually used in the synthesis of more complicated peptides. | ||
| S5622 | Prohydrojasmon | Prohydrojasmon is a newly launched plant growth regulator, which has jasmonic acid activity. | ||
| E0188 | Iron (III) hexacyanoferrate (II) | Iron (III) hexacyanoferrate (II) (Prussian Blue, Berlin blue) applied as sorbent for the efficient removal of heavy metals (Cu (II), Co (II), Ni (II) and Pb (II)) from aqueous solution. | ||
| E4009 | Sodium DL-lactate solution | Sodium DL-lactate solution (60% w/w aq. soln.) is the product of glycogenolysis and glycolysis. It is mainly used as a buffer and pH adjuster for injection solutions. It also has antimicrobial activity, which can be used as a food preservative. | ||
| S5237 | Dihydroartemisinic acid | Dihydroartemisinic acid is a natural product from Artemisia annua and the main direct precursor of artemisinin, which is a medicinal herb that is widely used to treat Malaria. | ||
| S5687 | Tropinone | Tropinone (3-Tropinone) is an alkaloid used for an intermediate in synthesis of atropine sulfate. | ||
| S6215 | Phthalic acid | Phthalic acid (1,2-Benzenedioic acid) is an aromatic dicarboxylic acid. It is a human xenobiotic metabolite. | ||
| S6488 | Gadoxetate sodium | Gadoxetate is a paramagnetic gadolinium-containing contrast agent in which its salt form, gadoxetate disodium, is used for intravenous injection. | ||
| E4011 | Glycogen (from bovine liver) | Glycogen (from bovine liver) is a glycolytic intermediates and high-energy phosphates that can serve as a form of energy storage in humans, animals, fungi, and bacteria. | ||
| S5107 | Riboflavin phosphate sodium | Riboflavin phosphate sodium (Flavin mononucleotide, riboflavin-5'-phosphate, FMN, Vitamin B2 Phosphate Sodium Salt) is a biomolecule produced from riboflavin (vitamin B2) by the enzyme riboflavin kinase and functions as prosthetic group of various oxidoreductases including NADH dehydrogenase as well as cofactor in biological blue-light photo receptors. | ||
| S5688 | Tropolone (NSC 89303) | Tropolone (NSC 89303, 2-Hydroxytropone, Purpurocatechol), a metal chelator, possesses weak antioxidative and radical-scavenging properties and shows a strong affinity for ferric ion. It is able to inhibit ferric iron reduction by catecholates, lowering the redox potential of the iron couple. | ||
| S5613 | 2-Thiohydantoin | 2-Thiohydantoin is a reactant for chemical synthesis. | ||
| S6217 | o-Toluic acid | o-Toluic acid (2-methylbenzoic acid, Orthotoluic acid) is an aromatic dicarboxylic acid. It is a human xenobiotic metabolite. | ||
| E2852 | BC-1471 | BC-1471, a small-molecule inhibitor of STAM-binding protein (STAMBP) deubiquitinase activity, decreases NACHT, LRR and PYD domains-containing protein 7 (NALP7) protein levels and suppresses IL-1β release after TLR agonism. | ||
| E4000 | Agar | Agar is a jelly like substance that contains agarose and agar gel isolated from the cell walls of red algae species such as Gelidium and Gracilaria (Ogonori). It is widely used in food additives, plant tissue culture, microorganisms culture media, fingerprint recognition, and medical fields. | ||
| E4902New | Dantrolene | Dantrolene is an antagonist of ryanodine receptor (RYR) and a postsynaptic skeletal muscle relaxant that reduces calcium release from the sarcoplasmic reticulum (SR), leading to a dose-dependent decrease in myoplasmic free calcium levels. It is used to treat and control the accelerated hypermetabolism of skeletal muscle that leads to a malignant hyperthermia crisis. | ||
| S6218 | Sodium lauryl sulfate | Sodium lauryl sulfate(Sodium dodecyl sulfate) is an anionic detergent and surfactant found in many personal care products. | ||
| S3257 | Rebaudioside B | Rebaudioside B (Reb B) is one of the minor steviol glycosides (SGs) isolated from Stevia rebaudiana and has a better taste quality than many of the major SGs. | ||
| S6304 | KL001 | KL001 is a stabilizer that specifically interacts with cryptochrome (CRY). KL001 prevents ubiquitin-dependent degradation of CRY, resulting in lengthening of the circadian period. | ||
| E4006 | Ribonucleic acid | Ribonucleic Acid (RNA) is the substrate for the RNase enzyme, which can be used for studying ribonuclease activities of enzymes such as ribonuclease-A, ribonuclease T1 (RNAase), and bougainvillea xbuttiana antiviral protein 1 (BBAP1). | ||
| A3176 | Human IgG2sa isotype control | Human IgG2sa isotype control is suitable for use as a non-targeting isotype control in various in vitro and in vivo studies, is the isotype control of human IgG2sa antibody. | ||
| S5690 | Triacanthine | Triacanthine, which could be isolated from the leaves of G. triacanthos, shows hypertensive activity, also cardiotonic, antispasmodic and a respiratory analeptic. | ||
| S6219 | β-Alanine methyl ester hydrochloride | β-Alanine ethyl ester is the ethyl ester of the non-essential amino acid β-alanine. | ||
| S3259 | Rebaudioside D | Rebaudioside D (Reb D) is one of the several glycosides (SGs) found in the leaves of Stevia rebaudiana (Bertoni) which has been identified as a potential sweetener. | ||
| P1245New | Bovine Serum Albumin | Bovine serum albumin (BSA, Albumin bovine serum) is an efficient passivating agent that inhibits nonspecific protein binding in assays such as ELISA. It is used to coat hydrophobic substrates, enhancing anti-fouling properties and reducing immune system interactions. | ||
| E2991 | Gold(III) chloride trihydrate | Gold(III) chloride trihydrate is a reducing agent. Gold(III) chloride trihydrate can be used for the chemical synthesis of gold nanoparticles (NP). | ||
| S5310 | 4,4'-Dimethoxybenzil | 4,4'-Dimethoxybenzil (p-Anisil) is a biochemical that has been reported to have mesomorphic properties of a substituted bis(dithiolene)nickel complex derived from 4,4′-dimethoxybenzil. | ||
| S6220 | Octanedioic acid | Octanedioic acid (Suberic acid) is a dicarboxylic acid used in drug syntheses and plastics manufacture. | ||
| E0451 | Dansylcadaverine (Monodansyl cadaverine) | Dansylcadaverine (Monodansyl cadaverine, MDC) is an autofluorescent compound used for the labeling of autophagic vacuoles. Dansylcadaverine, a high affinity substrate of transglutaminases, can block the receptor-mediated endocytosis of many ligands. |
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| E1388 | ISA-2011B | ISA-2011B is an inhibitor of phosphatidylinositol-4-phosphate 5-kinase-α (PIP5Kα). ISA-2011B exhibits anti-proliferative activity and induces apoptosis in prostate cancer cells. | ||
| S4562 | Dehydrocholic acid | Dehydrocholic acid (Decholin, Dehystolin, Felacrinos, Sanocholen) is a semisynthetic bile acid made from cholic acid. It is used as a cholagogue, hydrocholeretic, diuretic, and as a diagnostic aid. | ||
| S5482 | Prilocaine hydrochloride | Prilocaine hydrochloride is the hydrochloride salt form of prilocaine, which is a local anesthetic. | ||
| S5725 | Pempidine | Pempidine (Pyrilene, Perolysen, 1,2,2,6,6-Pentamethylpiperidine) is a long-acting ganglion-blocking compound. | ||
| S5868 | DL-Menthol | DL-Menthol is a racemic mixture of D- and L-menthol. Menthol is a covalent organic compound made synthetically or obtained from peppermint or other mint oils. | ||
| S3587 | Mebrofenin | Mebrofenin (SQ 26962) is a type of iminodiacetic acid (IDA) that is available as a ready to use the kit for radio-labeling with Technetium-99m (Tc-99m). Tc-99m Mebrofenin is used clinical for hepatobiliary scintigraphy. | ||
| E0190 | Invert sugar | Invert Sugar is a popular sweetener. | ||
| E2430 | Allocholic acid | Allocholic acid is a typically fetal bile acid found in vertebrates and reappears during liver regeneration and carcinogenesis. Allocholic acid is also a potent and specific stimulant of the adult olfactory system. | ||
| S7478 | AF38469 | AF38469 is a selective, orally bioavailable Sortilin inhibitor with an IC50 value of 330 nM. | ||
| E4013 | Melanin | Melanin is a unique pigment with myriad functions. It is multifunctional, providing defense against environmental stresses such as ultraviolet (UV) light, oxidizing agents and ionizing radiation. | ||
| S4563 | Diatrizoic acid | Diatrizoic Acid (Amidotrizoic acid, Diatrizoate) is an organic, iodinated radiocontrast agent used in diagnostic radiography. | ||
| S3986 | L-Arabinose | L-Arabinose (L-Ara) is a plant saccharide that is not found in animals. It is a component of cell wall and may be useful as a natural pharmaceutical. | ||
| S5462 | 5-O-Methylvisammioside | 5-O-Methylvisammioside is a naturally occuring product isolated from Saposhnikovia Divaricata and has analgesic, antipyretic, anti-inflammatory and anti-platelet aggregation effects. | ||
| S5867 | Bendazac L-lysine | Bendazac L-lysine has a protective effect against lens protein denaturation both in vitro and in vivo. It is also a nonsteroidal anti-inflammatory drug (NSAID) used for joint and muscular pain. | ||
| S6798 | ELN484228 | ELN484228 is a cell-permeable blocker that targets α-synuclein, a key protein in Parkinson’s disease. | ||
| S2766 | Glycerol | Glycerol (Glycerin) is a clear, colourless and viscous liquid that can be used as emollient, solvent or sweetening agent. Glycerol changes the separation characteristics of polyacrylamide nucleoprotein gels and prevents dissociation of nucleosomes and other protein-DNA complexes during electrophoresis. | ||
| S3282 | Rebaudioside M | Rebaudioside M, isolated from Stevia rebaudiana Bertoni, is a natural non-caloric potential sweetener in food and beverage products. | ||
| E0145 | LOX-IN-3 Dihydrochloride | LOX-IN-3 Dihydrochloride is an orally active and selective lysyl oxidase (LOX) inhibitor. | ||
| E2957 | N-Dodecyl beta-D-maltoside | N-Dodecyl-β-D-maltoside (Lauryl Maltoside) is a derivatives of pyrene (Py). It is alkyl maltopyranoside detergent, especially in transporters and respiratory complexes. N-Dodecyl-β-D-maltoside has also been employed in applications such as in the purification and stabilization of RNA polymerase and detection of protein-lipid interactions. | ||
| S5024 | Miriplatin | Miriplatin (SM-11355) is a derivative of cisplatin containing myristates as a carrier ligand. It is a novel lipophilic platinum complex developed to treat hepatocellular carcinoma.DMSO is not recommended to dissolve platinum-based drugs, which can easily lead to drug inactivation. | ||
| S5626 | Benzalkonium chloride | Benzalkonium chloride, a detergent and preservative found in health care and household products, is an established irritant. | ||
| S9372 | Ethyl palmitate | Ethyl palmitate (Ethyl hexadecanoate, Palmitic acid ethyl ester) is a long-chain fatty acid ethyl ester that is used as a hair- and skin-conditioning agent. | ||
| S5760 | 6-Chloro-7-hydroxy-4-methylcoumarin | 6-Chloro-7-hydroxy-4-methylcoumarin is a pharmaceutical intermediate. | ||
| S5866 | Gastrodenol | Gastrodenol (Bismuth tripotassium dicitrate) is used to treat certain conditions caused by too much acid being produced in the stomach, such as stomach ulcers and ulcers of the upper part of the intestine (duodenal ulcers). | ||
| E0187 | N-hydroxymethyl succinimide | N-hydroxymethyl succinimide is used as pharmaceutical intermediate. | ||
| E4017 | Calcium chloride dihydrate | Calcium chloride dihydrate is a moisture-resistant, cheap, and commonly available calcium salt. It is used as a calcium supplement in the DMEM (Dulbecco's modified Eagle's medium) for use in cell culture studies and to prepare the synthetic brine solution. | ||
| S5461 | Cimicifugoside | Cimicifugoside is a triterpenoid originating from the rhizomes of Cimicifuga simplex, and acts to inhibit the subcellular transport of nucleosides. | ||
| S9455 | Isorhamnetin 3-O-neohesperoside | Isorhamnetin 3-O-neohesperoside is the major active substance of Puhuang, a traditional herb medicine widely used in clinical practice to tackle many chronic diseases. It has significant biological and pharmacological activities, including antioxidant, antiatherogenic and antimicrobial effects. | ||
| S6229 | Lauryl gallate | Lauryl gallate (Dodecyl gallate) is the ester of dodecanol and gallic acid that exhibits both potent chain-breaking and preventive antioxidant activity. | ||
| S6960 | Auxinole | Auxinole is a potent auxin antagonist that binds to TIR1 and blocks the formation of the TIR1-IAA-Aux/IAA complex. Auxinole is an OsTIR1 inhibitor that suppresses leaky degradation of degron-fused proteins. | ||
| E4019 | Polyethylenimine | Polyethylenimine (PEI) is a hydrophilic cationic polymer that acts as a low toxicity and efficient gene vector. | ||
| E1810 | dCeMM1 | dCeMM1 is a degrader of RBM39. dCeMM1 functions by altering the activity of the CRL4DCAF15 ligase, and also decreases RBM39 expression levels in wild-type KBM7 cells. | ||
| S4414 | Sodium 4-aminohippurate | Sodium 4-aminohippurate(Aminohippurate sodium) is a derivative of hippuric acid. | ||
| S3989 | L-Histidine | L-Histidine (Glyoxaline-5-alanine) is an α-amino acid needed in humans for growth and tissue repair. It is used in the biosynthesis of proteins. | ||
| S9380 | 5,7-Dihydroxy-4-methylcoumarin | 5,7-Dihydroxy-4-methylcoumarin may be used for pharmaceutical synthesis. | ||
| S9186 | Liensinine perchlorate | Liensinine is the active constituent of plumula nelambinis with anti-hypertension. | ||
| S9511 | Crocin I | Crocin-I, a major member of the crocin family, has antidepressant activity and ameliorates the disruption of lipid metabolism and dysbiosis of the gut microbiota induced by chronic corticosterone in mice. | ||
| S5865 | Hyaluronic acid (Hyaluronan) | Hyaluronic acid (Hyaluronan) is an anionic, nonsulfated glycosaminoglycan distributed widely throughout connective, epithelial, and neural tissues. It is widely used in skin care. | ||
| S6231 | Methyl nicotinate | Methyl nicotinate (methyl pyridine-3-carboxylate) is an ester of methyl alcohol and nicotinic acid. It is a rubefacient. | ||
| S6782 | Anle138b | Anle138b is a novel oligomer modulator and an aggregation inhibitor, blocking the formation of pathological aggregates of prion protein (PrP(Sc)) and of α-synuclein (α-syn) with good oral bioavailability, blood-brain-barrier penetration and no detectable toxicity. Anle138b shows a new approach for disease-modifying therapy in neurodegenerative diseases such as prion and Parkinson's disease. | ||
| S3285 | Dihydrolycorine | Dihydrolycorine is a derivative of lycorine, an alkaloid isolated from Lycoris radiata Herb. Dihydrolycorine blocks protein synthesis in ascites cells and stabilize HeLa cell polysomes in vivo. Dihydrolycorine exhibits antihypertensive and neuroprotective activities. | ||
| E2830 | Cyclocreatine | Cyclocreatine is a Creatine analogue and acts as a potent bioenergetic protective agent by preserving high levels of ATP. | ||
| E2965 | 4-Nitrophenyl-2-acetamido-2-deoxy-β-D-glucopyranoside | 4-Nitrophenyl-2-acetamido-2-deoxy-β-D-glucopyranoside is a useful substrate for rapid colorimetric assay of N-acetyl-b-glucosaminidase activity in human urine. Chromogenic β-Glucosaminidase substrate yielding a yellow solution upon cleavage, employed particularly in yeasts and molds. | ||
| S9515 | Polyphyllin VII | Polyphyllin VII (Y-0166), the the main member of polyphyllin family, shows strong anticancer activity against several carcinomas, including lung cancer, breast cancer, colorectal cancer, cervical cancer, hepatocellular carcinoma and osteosarcoma. | ||
| S6232 | Methylamine hydrochloride | Methylamine is used as a building block for the synthesis of many other commercially available compounds. | ||
| S4496 | Maltose monohydrate | Maltose (Maltobiose, Malt Sugar, Beta-Maltose, D-Maltose) monohydrate, an non-essential nutrient that provides energy, is an intermediate in the intestinal digestion of glycogen and starch, and is found in germinating grains (and other plants and vegetables). | ||
| E4018 | Ammonium sulfate | Ammonium sulphate (Mascagnite) is an inorganic sulfate salt used for the purification of enzymes and antibodies. | ||
| S6769 | Curcumin analog C1 | Curcumin analog C1 (Curcumin analog Compound C1) is a potent transcription factor EB (TFEB) activator with promise for the prevention or treatment of Alzheimer's disease. | ||
| S5182 | GSK4112 | GSK4112 is a functional Rev-erbα agonist with an EC50 of 0.4 μM. It represses the expression of gluconeogenic genes in liver cells and reduces glucose output in primary hepatocytes. | ||
| E1602 | Lotiglipron | Lotiglipron (PF-07081532) is an orally active GLP-1R agonist. It reduces glucose and body weight, and has the potential to be used in Type 2 diabetes mellitus (T2DM) research. | ||
| E1889New | PCO371 | PCO371 is a nonpeptidyl, orally active agonist of Parathyroid hormone type 1 receptor (PTHR1). It stimulates cAMP production in COS-7 cells with an EC50 of 2.4 μmol/L. It also acts as an osteoporosis drug and significantly enhances bone mineral density (BMD) and bone strength in the lumbar vertebrae of osteopenic ovariectomized (OVX) rats. It also restores normal serum calcium levels without increasing urinary calcium in hypocalcemic thyroparathyroidectomized (TPTX) rats. | ||
| S0989 | ML-180 | ML-180 (SR1848) is a potent inverse agonist of orphan nuclear receptor NR5A2 (Liver receptor homologue-1, LRH1) with IC50 of 3.7 μM. ML-180 has the potential for LRH-1-dependent cancers. | ||
| E0620 | LIT-001 trifluoroacetate | LIT-001 trifluoroacetate(LIT-001 TFA) is the first nonpeptide oxytocin receptor (OXTR) agonist that improves social interaction in a mouse model of autism. | ||
| E2686 | Methoprene | Methoprene is a growth-regulating insecticide that manifests its toxicity to target organisms by acting as a juvenile hormone agonist. | ||
| E1256 | Ibotenic acid | Ibotenic acid((RS)-Ibotenic acid; DL-Ibotenic acid) is a neuroexcitatory amino acid originally isolated from Amanita species. It exhibits agonist activity at both N-methyl-D-aspartate (NMDA) and trans-ACPD) or metabolotropic quisqualate (Qm) receptor sites. | ||
| E7144New | PAR-4 Agonist Peptide, amide | PAR-4 Agonist Peptide, amide is a agonist of proteinase-activated receptor-4 (PAR-4) that provides antinociceptive effects in stress- and inflammation-induced hyperalgesia. It reduces visceral pain by activating PAR-4 receptors on colonic nerve terminals. | ||
| E1716 | SR9011 | SR9011 is a REV-ERBα/β agonist with IC50s of 790 nM and 560 nM for REV-ERBα and REV-ERBβ, respectively. It is specifically lethal to cancer cells and oncogene-induced senescent cells, including melanocytic naevi. | ||
| S2474 | Fabomotizole hydrochloride | Fabomotizole hydrochloride (Fabomotizole, CM346, CM346, Afobazol, Afobazole) exhibits anxiolytic and neuroprotective properties. Fabomotizole hydrochloride is a potent sigma1-receptor agonist with IC50 of 7.1 µM and Ki of 5.9 µM. | ||
| S6775 | TUG-891 | TUG-891 is a potent and selective agonist of the long chain free fatty acid (LCFA) receptor 4 (FFA4/GPR120), which demonstrates both potential opportunity and possible challenges to therapeutic agonism. | ||
| A3176 | Human IgG2sa isotype control | Human IgG2sa isotype control is suitable for use as a non-targeting isotype control in various in vitro and in vivo studies, is the isotype control of human IgG2sa antibody. | ||
| S2610 | Lonidamine | Lonidamine is an orally administered small molecule hexokinase inactivator. | ||
| E1249 | Blebbistatin | Blebbistatin is a selective inhibitor of non-muscle myosin II (NMII). It also potently inhibits several striated muscle myosins as well as vertebrate nonmuscle myosin IIA and IIB with IC50 values ranging from 0.5 to 5 μM. It promotes directional migration of corneal endothelial cells (CECs) and accelerates wound healing, and better preserves cell junctional integrity and barrier function. | ||
| S7443 | AP-III-a4 (ENOblock) | AP-III-a4 (ENOblock) is the first nonsubstrate analogue inhibitor of enolase with IC50 of 0.576 μM. | ||
| S2256 | 4-Methylumbelliferone (4-MU) | 4-Methylumbelliferone is a hyaluronic acid (HA) synthesis inhibitor with an IC50 of 0.4 mM. | ||
| S9670 | Pitstop 2 | Pitstop 2 is an inhibitor of the interaction of amphiphysin with the amino terminal domain of clathrin that inhibits both clathrin-dependent endocytosis (CDE) and clathrin independent endocytosis (CIE). | ||
| S6415 | Azeliragon (TTP488) | Azeliragon (TTP488, PF-04494700) is an orally bioavailable small molecule that inhibits the receptor for advanced glycation endproducts (RAGE), which is an immunoglobulin-like cell surface receptor overexpressed in brain tissues of patients with AD. | ||
| S8674 | GO-203 | GO-203 is a D-amino acid cell-penetrating peptide inhibitor of MUC1-C dimerization and thereby its oncogenic function. | ||
| S9192 | Vitexin | Vitexin (Apigenin-8-C-glucoside), an naturally occuring apigenin flavone glycoside, acts as a platelet aggregation and alpha-glucosidase inhibitor and shows antineoplastic activity. | ||
| S7589 | N6022 | N6022 is a selective, and reversible inhibitor of S-nitrosoglutathione reductase (GSNOR) with IC50 of 8 nM and Ki of 2.5 nM. Phase 1/2. | ||
| S0338 | NB 598 | NB-598 is a potent, competitive squalene epoxidase (SE) inhibitor. NB-598 suppresses cholesterol biosynthesis. | ||
| S3199 | Reboxetine mesylate | Reboxetine mesylate (PNU 155950E, FCE20124) is a norepinephrine reuptake inhibitor with Ki of 8.2 nM. | ||
| S1875 | Tranexamic Acid | Tranexamic Acid(Transamin) is an antifibrinolytic for blocking lysine-binding sites of plasmin and elastase-derived plasminogen fragments with IC50 of 5 mM. | ||
| S4567 | Eprodisate disodium | Eprodisate Disodium (NC-503) is the orally available disodium salt form of Eprodisate, a small-molecule, orally bioavailable, inhibitor of AA-amyloid fibrillogenesis. |
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| S6628 | E7820 | E7820 is a unique angiogenesis inhibitor with antitumor activities. | ||
| S9885 | MYLS22 | MYLS22 is a first-in-class and selective inhibitor of optic atrophy 1 (OPA1) with anti-angiogenesis and anti-cancer activity. | ||
| S6767 | GSK805 | GSK805 (JNJ 56914845, GSK-2336805) is a potent and orally bioavailable RORγt inhibitor. | ||
| S4108 | Clodronate Disodium | Clodronate Disodium, a bisphosphonate, is a potent antiosteolytic agent which inhibits bone resorption. | ||
| S5779 | Trimetazidine | Trimetazidine is an anti-ischemic (anti-anginal) metabolic agent, which improves myocardial glucose utilization through inhibition of long-chain 3-ketoacyl CoA thiolase activity and results in a reduction in fatty acid oxidation and a stimulation of glucose oxidation. | ||
| S9505 | Oleanonic Acid | Oleanonic Acid (3-Ketooleanolic Acid, 3-Oxooleanolic acid), extracted from Pistacia terebinthus galls, is a cell cycle inhibitor and used as antitumor agents. | ||
| S1624 | Alendronate sodium trihydrate | Alendronate sodium trihydrate (G-704650, MK-217), a nitrogen-containing bisphosphonate, is a potent inhibitor of bone resorption used for the treatment and prevention of osteoporosis. | ||
| S2129 | Fudosteine | Fudosteine is a cysteine derivative and a MUC5AC mucin hypersecretion inhibitor, used as a muco-active agent with indications for chronic respiratory diseases. | ||
| S4020 | Sodium Picosulfate | Sodium Picosulfate inhibits absorption of water and electrolytes, and increases their secretion. | ||
| S5621 | Cilastatin | Cilastatin(MK0791) is a renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. | ||
| S9385 | Ligustilide | Ligustilide is the most abundant bioactive ingredient in Rhizoma Chuanxiong, a Chinese medicinal herb commonly used for the treatment of cardiovascular ailments.Solutions are unstable and should be fresh-prepared. | ||
| E2178 | IM-54 | IM-54 is a selective inhibitor of oxidative stress-induced necrosis. IM-54 shows potent inhibitory activity against H2O2-induced necrosis. | ||
| E0498 | BMS-986176 | BMS-986176 (LX-9211,AAK1-IN-1) is a highly selective, brain-penetrant, potent AAK1 (adaptor associated kinase 1) inhibitor with an IC50 of 2 nM. | ||
| E1213 | Emlenoflast (MCC-7840) | Emlenoflast (MCC-7840), a sulfonylurea, is a potent and selective inhibitor of NLRP3 inflammasome, with an IC50 of <100 nM. | ||
| E0111 | BRM/BRG1 ATP Inhibitor-1 | BRM/BRG1 ATP Inhibitor-1 (Compound 14) is an orally active inhibitors of Brahma Homolog (BRM)/SMARCA2 (BRG1) with IC50s below 0.005 µM. | ||
| S9020 | Dihydrotanshinone I | Dihydrotanshinone I (15,16-dihydrotanshinone I) is a naturally occurring compound extracted from Salvia miltiorrhiza Bunge, also known as Chinese sage, red sage root, and the Chinese herbal Dan Shen. It is a potent inhibitor of the HuR:RNA interaction, active in the low nanomolar range, mainly by limiting the association rate of HuR with RNA. | ||
| S0145 | ML329 | ML329 is an inhibitor of micropthalmia-associated transcription factor (MITF) that inhibits TRPM-1 promoter activity with IC50 of 1.2 μM. | ||
| S9080 | Anhydroicaritin | Anhydroicaritin (Cycloicaritin), a prenylated flavonoid natural product, is commonly recognized as one of the effective compounds of Epimedii Herba and exhibits a variety of biological activities, such as activation of cancer cell apoptosis and inhibition of growth, protection against beta amyloid-induced neurotoxicity, and promotion of neuronal and cardiac cellular differentiation. It is a potent inhibitor of transcription factor SREBPs. | ||
| E1010 | BZ1 | BZ1 (BPTF inhibitor, BPTF-IN-BZ1) is a pyridazinone-based BPTF (Bromodomain PHD Finger Transcription Factor) inhibitor with a high potency (Kd = 6.3 nM) and >350-fold selectivity over BET bromodomains. | ||
| S3694 | Glucosamine hydrochloride | Glucosamine (2-Amino-2-deoxy-glucose, Chitosamine) is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, also presents in the shells of shellfish, animal bones, bone marrow, and fungi. Glucosamine is commonly used as a treatment for osteoarthritis, although its acceptance as a medical therapy varies. | ||
| S0189 | PMPA tetrasodium salt | PMPA tetrasodium salt (PMPA sodium) is a potent and selective inhibitor of glutamate carboxypeptidase 2 (GCP II/NAALADase). | ||
| S0206 | CTX-0294885 | CTX-0294885, a bisanilino pyrimidine, is a novel broad-spectrum kinase inhibitor. CTX-0294885 is further developed into a Sepharose-supported kinase capture reagent. | ||
| S6781 | Brassinazole | Brassinazole (BRZ) is a potent inhibitor of brassinosteroid (BR) biosynthesis with IC50 of ~ 1 μM, that has been developed to probe the myriad functions of brassinosteroids. Brassinosteroids are a class of phytohormones with essential roles in plant growth and development, including the promotion of stem elongation and cell division. | ||
| S6529 | NIH-12848 | NIH-12848 is a specific PI5P4Kγ inhibitor with an IC50 of approximately 1 μM but does not inhibit the α and β PI5P4K isoforms at concentrations up to 100 μM. | ||
| S4730 | Pyrithioxin Dihydrochloride | Pyrithioxin (Bonifen, Encefabol, Pyritinol, Vitamin B6 disulfide) Dihydrochloride is a neurotropic agent which reduces permeability of blood-brain barrier to phosphate with no vitamin B6 activity. | ||
| E4030 | N-p-Tosyl-L-phenylalanine chloromethyl ketone | N-p-Tosyl-L-phenylalanine chloromethyl ketone (Tosyl phenylalanyl chloromethyl ketone, TPCK) is an irreversible inhibitor of chymotrypsin-like proteases that affect cell proliferation, apoptosis, and tumorigenesis. | ||
| S0712 | Endoxifen E-isomer | Endoxifen E-isomer (E-Endoxifen), an E-isomer of Endoxifen and impurity in Endoxifen Z-isomer drug substance, exhibits antiestrogenic effects. | ||
| E1484 | PDS-0330 | PDS-0330 is an inhibitor of Claudin-1, which inhibits claudin1-mediated signalling by interfering with its binding to Src. PDS-0330 exhibits an antitumor effect and enhances apoptosis in colorectal cancer cells. | ||
| E1360New | BAY-069 | BAY-069 is a potent dual inhibitor of BCAT1/2 (branched-chain amino acid transaminases), with IC50 values of 31 nM for BCAT1 and 153 nM for BCAT2. It demonstrates high cellular activity, excellent selectivity, and is used as an in vitro probe. | ||
| E1915New | DDO-2728 | DDO-2728 is a selective pyrazolopyrimidine-based inhibitor of ALKBH5 with an IC50 of 2.97 μM. It increases the levels of N6-methyladenosine (m6A) modifications in acute myeloid leukemia (AML) cells and exhibits antiproliferative activity in these cells. It also demonstrates anti-tumor efficacy in the MV4−11 xenograft model. | ||
| S5306 | Forchlorfenuron (CPPU) | Forchlorfenuron (CPPU) is a synthetic cytokinin that inhibits septins and exhibits anti-parasitic, anticancer, and anti-angiogenic activities. | ||
| E2361 | KR-33494 | KR-33494 is a potent inhibitor of Fas-mediated cell death (FAF1). | ||
| S6501 | NVP 231 | NVP 231 is a novel CerK inhibitor that inhibits the catalytic activity of recombinant CerK in vitro with an IC50 of 12 nM. | ||
| E2194 | Skimmianine | Skimmianine, a furoquinoline alkaloid present mainly in the Rutaceae family, with antispastic, anti-inflammatory activities and antiplatelet aggregation effect, exhibits cytotoxicity against a variety of cancer cell lines and genotoxicity. | ||
| E1685 | D609 | D609 is a selective, competitive inhibitor of phosphatidylcholine-specific phospholipase C (PC-PLC) with a Ki of 6.4 μM. It is an antioxidative protector and has antiviral and anti-inflammatory activity and also inhibits angiogenesis by preventing the synthesis of basement membrane (BM). | ||
| E1389 | Eeyarestatin I | Eeyarestatin I is a potent inhibitor of endoplasmic reticulum-associated protein degradation (ERAD). Eeyarestatin I also inhibits Sec61 translocon. | ||
| S3230 | L-Fucitol | L-Fucitol (1-Deoxy-D-galactitol), a galactitol analogue isolated from Myristica fragrans (Nutmeg), inhibits galactitol-positive strains of Escherichia coli K12. | ||
| E0454 | ARN-19702 | ARN19702 is an orally active, reversible N-Acylethanolamine acid amidase(NAAA) inhibitor (IC50 on human NAAA = 230 nM) that produces remarkable protective effects against multiple sclerosis in mice. | ||
| S5325 | Nitisinone (NTBC) | Nitisinone (NTBC) is a synthetic reversible inhibitor of 4-hydroxyphenylpyruvate dioxygenase used in the treatment of hereditary tyrosinemia type 1. | ||
| E2511 | ZINC05007751 | ZINC05007751 is a potent NIMA-related kinase NEK6 inhibitor with an IC50 of 3.4 μM, shows antiproliferative activity against a panel of human cancer cell lines and displays a synergistic effect with Cisplatin and Paclitaxel in a BRCA2 mutated ovarian cancer cell line. | ||
| E4432 | 3,3-Dimethyl-1-butanol | 3,3-Dimethyl-1-butanol (Neohexanol) is an orally active inhibitor of trimethylamine (TMA) and trimethylamine N-oxide (TMAO). 3,3-dimethyl-1-butanol negatively inhibits the signalling pathways of p65 NF-κB and TGF-β1/Smad3. 3,3-dimethyl-1-butanol has potential applications in cardiovascular disease (CVD). | ||
| S0727 | KUN50259 (DAAO inhibitor-1) | KUN50259 (DAAO inhibitor-1, Compound 35) is a potent inhibitor of D-amino acid oxidase (DAAO) with an IC50 of 0.12 μM. | ||
| E2674 | CP-24879 hydrochloride | CP-24879, an aniline derivative, is a potent, selective inhibitor of Delta(5)/Delta(6) desaturase. | ||
| S5011 | Disodium Phosphate | Disodium Phosphate (Sodium hydrogen phosphate, Sodium phosphate dibasic) is an inorganic compound used usually as food additives. It is also functions as a corrosion inhibitor. | ||
| E1288New | Inaxaplin | Inaxaplin (VX-147) is an orally active inhibitor of apolipoprotein L1 (APOL1) function. Inaxaplin binds to APOL1 and is useful in the treatment of APOL1-associated kidney disease. | ||
| S6286 | Tricarballylic acid | Tricarballylic acid (β-Carboxyglutaric acid, Propane-1,2,3-tricarboxylic acid) is an inhibitor of aconitase and therefore interferes with the Krebs cycle. | ||
| E1966New | VVD-214 | VVD-214 (RO7589831, VVD-133214) is a synthetic allosteric inhibitor of WRN helicase. VVD-214 binds irreversibly to cysteine 727 on WRN, suppressing ATP hydrolysis and helicase activity. VVD-214 exhibits potent efficacy in inducing double-stranded DNA breaks, nuclear enlargement, and cellular apoptosis in cancers with high microsatellite instability (MSI). | ||
| E1908New | HRO761 | HRO761 is a potent, selective, allosteric inhibitor of Werner syndrome RecQ helicase (WRN). It binds at the interface of the D1 and D2 helicase domains, locking WRN in an inactive conformation, and demonstrates anti-proliferative effects specifically in microsatellite instability (MSI) cancer cells. | ||
| S3490 | ML349 | ML349 is a potent and specific inhibitor ofacyl protein thioesterase 2(APT2)/lysophospholipase 2 (LYPLA2) with a Ki of 120 nM and IC50 of 144 nM respectively. It exhibits reduction in MCF10A and Snail cell proliferation. | ||
| E1982New | SOP1812 | SOP1812( QN-302), is a tetra-substituted naphthalene diimide (ND) derivative and selective inhibitor of G-quadruplex (G4) transcription. It shows great affinity to hTERT G4 and HuTel21 G4 with KD values of 4.9 and 28.4 nM, respectively. It binds to G-quadruplex DNA in cancer gene promoters region and shows strong anti-proliferative and anti-tumor activity in pancreatic cancer models. | ||
| E1672New | NMDI14 | NMDI14(DA-66137) is an inhibitor of nonsense-mediated RNA decay (NMD). NMDI14 disrupts the SMG7-UPF1 interactions and inhibits NMD. NMDI14 increases the stability and expression of NMD targeted mRNAs. | ||
| E1788New | CQ211 | CQ211 is a cell penetrant, potent and selective inhibitor of RIOK2(Right open reading frame kinase 2) with a Kd of 6.1 nM. It effectively inhibits cancer cell proliferation and shows promising in vivo efficacy in mouse xenograft models. | ||
| E4592New | UGT8-IN-1 | UGT8-IN-1 is a brain-penetrable and orally active inhibitor of ceramide galactosyltransferase enzyme (UGT8). UGT8-IN-1 targets sulfatide metabolism resulting in ceramide-induced lethal mitophagy and subsequent cancer cell death in vitro, and reduces tumour growth in mutant Kras; Gnas allografts. | ||
| S0943 | Arenobufagin | Arenobufagin is a natural bufadienolide from toad venom and induces apoptosis and autophagy in human hepatocellular carcinoma cells through inhibition of PI3K/Akt/mTOR pathway. | ||
| E0353 | Potassium oxonate | Potassium oxonate (Oxonic Acid Potassium Salt) is a selectively competitive uricase inhibitor, produced hyperuricemia (HUA) in rodents. | ||
| E0469 | GW 610 | GW 610 (NSC 721648), an antitumor agent, shows potent and selective anticancer activity against lung, colon, and breast cancer cell lines. | ||
| E0466 | Adarotene | Adarotene (ST1926) causes a dose-dependent growth inhibition in a large panel of human tumor cell lines with IC50 ranging from 0.1 to 0.3 µM, causes cell accumulation in G1/S or S phase of cell cycle depending on tumor cells, exhibiting a potent antiproliferative activity. | ||
| E4940New | Chlorphenesin carbamate | Chlorphenesin carbamate(Maolate, Rinlaxer, U 19646) is a centrally-acting muscle relaxant that inhibits motoneuron excitability. It is also used to treat pain and discomfort related to skeletal muscle trauma and inflammation. | ||
| E1698 | EN460 | EN460 is a small-molecule inhibitor of endoplasmic reticulum oxidation 1(ERO1), which is specific for the reduced active form of ERO1α and prevents re-oxidation. It also protects cells from erastin-induced ferroptosis. | ||
| E4830New | Guanidine thiocyanate | Guanidine thiocyanate is a potent inhibitor of nucleases and a powerful denaturant of proteins. It is used for RNA isolation due to its strong chaotropic properties, which effectively denature RNase enzymes in samples, ensuring RNA stability and purity during extraction processes. Nucleic acid extraction buffers containing guanidine thiocyanate effectively deactivate high-titer polioviruses found in potentially infectious materials. | ||
| E0240 | Procyanidin B1 | Procyanidin B1, a natural polyphenolic compound that has antioxidant properties, inhibits Kv10.1 channel and suppresses the evolution of hepatoma. |
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| S9729 | Visomitin (SKQ1) | Visomitin (SKQ1) is a novel mitochondrial-targeted antioxidant that holds promise in the treatment of inflammation associated with ocular surface diseases such as dry eye disease (DED) and corneal wounds. SkQ1 shows a TC50 of 317 nM on HCjE cells. | ||
| E1694 | Sardomozide dihydrochloride | Sardomozide dihydrochloride (CGP 48664A) is a potent inhibitor of S-adenosylmethionine decarboxylase (SAMDC) with an IC50 of 5 nM. It is also a potent inhibitor of polyamine oxidase and exhibits with broad spectrum antiproliferative and antitumor activity. | ||
| E1885New | LY3522348 | LY3522348 is a highly selective oral dual inhibitor of the human ketohexokinase isoforms C and A, with IC50 values of 20nM for hKHK-C and 24nM for hKHK-A. It shows a significant pharmacodynamic effect in a mouse model of fructose metabolism. | ||
| S8970 | HQNO | HQNO (2-heptyl-4-hydroxyquinoline-N-oxide) is a natural quinolone secreted by P. aeruginosa. HQNO is a potent inhibitor of the electron transport chain with Kd of 64 nM for the ubiquinol-ferricytochrome c oxidoreductase segment (Complex III) of the respiratory chain. HQNO is also an inhibitor of bacterial and mitochondrialType II NADH : quinone oxidoreductase (NDH-2) with IC50 of 7.3 μM in the presence of 50μM menadione. | ||
| S3389 | Heptamidine Dimethanesulfonate | Heptamidine (SBi4211) Dimethanesulfonate is a novel and potent Pentamidine-related inhibitor of the calcium-binding protein S100B with a Kd of 6.9 μM. | ||
| S4881 | Calcium Dobesilate | Calcium dobesilate (calcium dihydroxy-2,5-benzenesulfonate) is a small molecule that has been widely used for treating diabetic retinopathy and chronic venous insufficiency. | ||
| E1703New | SF2312 | SF2312 is a highly potent inhibitor of Enolase with IC50s of 37.9 nM and 42.5 nM for human recombinant ENO1 and ENO2, respectively, and also is a natural phosphonate antibiotic. SF2312 displays activity against bacteria under anaerobic conditions. | ||
| E2834 | Hck-IN-1 | Hck-IN-1, a selective Nef-dependent Hck inhibitor, blocks the kinase activity of the Nef:Hck complex in vitro with an IC50 value of 2.8 μM, whereas its activity against Hck alone is >20 μM, also blocks wild-type HIV-1 replication with an IC50 value in the 100-300 nM range. | ||
| E1692 | BAY 2965501 | BAY 2965501 is a potent selective inhibitor of diacylglycerol kinases zeta (DGKζ), restores T-cell cellular DAG level, and induces pERK activation in anergic T-cells via DGK inhibition to assist T-cell mediate tumor cell kill. | ||
| S6607 | YL-109 | YL-109 is a novel antitumor agent that has ability to inhibit breast cancer cell growth and invasiveness in vitro and in vivo. | ||
| E1691 | Muvalaplin(LY3473329) | Muvalaplin(LY3473329) is an orally administered small molecule that inhibits lipoprotein (a) (Lp (a)) formation by blocking the apo(a)-apo B100 interaction. It can be used in research of atherosclerotic disease and aortic stenosis. | ||
| E0487 | SP-8356 | SP-8356, an anti-inflammatory synthetic verbenone derivative, is a CD147 inhibitor with respect to its regulation of breast cancer cell behavior and cancer progression. | ||
| E2863 | Garcinia cambogia extract | Garcinia cambogia extract has hypocholesterolemic effect and used for obesity treatment. (-)-hydroxycitrate (HCA), the chief compound of standardized Garcinia cambogia extract, is a competitive inhibitor of ATP-citrate-lyase. | ||
| E4634New | MIRA-1 | MIRA-1(NSC 19630), a maleimide compound, is a selective inhibitor of Werner syndrome WRN helicase activity with an IC50 of 20 µM while sparing ATPase and exonuclease activities. It reactivates mutant p53, inducing apoptosis in various human solid tumor cell lines with tetracycline-regulated mutant p53. | ||
| E1533New | Lipofermata | Lipofermata is an inhibitor of fatty acid transport protein 2 (FATP2) that demonstrates fatty acid transport inhibition with an IC50 of 4.84 μM in Caco-2 cells. It may offer therapeutic potential for diseases where lipotoxicity is a key factor. | ||
| E1403New | Fumarate hydratase-IN-1 | Fumarate hydratase-IN-1 is a small molecule cell-permeable inhibitor of fumarate hydratase. It induce alteration of TCA cycle metabolites, modulation of cytosolic processes, and substantial redox stress responses. | ||
| E1216 | Heclin | Heclin is an inhibitor of HECT-type E3 ubiquitin ligase with an IC50 of 6.8, 6.3, and 6.9 μM for Smurf2, Nedd4, and WWP1 HECT domains, respectively. | ||
| S6668 | NVS-ZP7-4 | NVS-ZP7-4,a Zinc transporter SLC39A7 (ZIP7) inhibitor,is the first reported chemical tool to probe the impact of modulating ER zinc levels and investigate ZIP7 as a novel druggable node in the Notch pathway. | ||
| E7278New | L-Methionine-DL-sulfoximine | L-Methionine-DL-sulfoximine (MSX, MSO) is an irreversible inhibitor of glutamine synthetase (GS) and pre-treatment delays the onset of behavioral and electrographic seizures in Pilo-treated rats. It also acts as a potent convulsant that metabolically and morphologogically primarily affects astroglia. | ||
| E1904New | SKF-34288 hydrochloride | SKF-34288 hydrochloride(3-Mercaptopicolinic acid hydrochloride, 3-MPA hydrochloride) is an orally active, specific inhibitor of phosphoenolpyruvate carboxykinase (PEPCK) with Ki values of 2-9 μM. SKF-34288 hydrochloride is a potent hypoglycemic agent by inhibiting glucose synthesis. SKF-34288 hydrochloride also inhibits cell proliferation, induces myogenic differentiation in vitro. | ||
| S0984 | KCC-07 | KCC-07 is a potent, selective and brain-penetrant inhibitor of MBD2 (methyl-CpG-binding domain protein 2) with anticancer activity. It prevents binding of MBD2 to methylated DNA and activates brain specific angiogenesis inhibitor 1 (BAI1) inducing anti-proliferative BAI1/p53/p21 signaling. | ||
| S4153 | D-Phenylalanine | D-Phenylalanine, a carboxypeptidase A, endorphinase and enkephalinase inhibitor, enhances endorphin production and diminishes pain. | ||
| E1148 | BOS-318 | BOS-318 is a potent, slowly dissociating, highly selective, and cell-permeable furin inhibitor with IC50 value of 1.9 nM. | ||
| E0791 | PTGR2-IN-1 | PTGR2-IN-1 is a potent prostaglandin reductase 2 (PTGR2) inhibitor with an IC50 of ~0.7 μM. | ||
| S7821 | Bufalin | Bufalin (BF) is a potent inhibitor of steroid receptor coactivator SRC-3, SRC-1 and Na+/K+-ATPase. Bufalin binds to the subunit α1, α2 and α3 of Na+/K+-ATPase with Kd of 42.5 nM, 45 nM and 40 nM, respectively. Bufalin is a major digoxin-like immunoreactive component isolated from the Chinese medicine Chan Su with anti-cancer activity. | ||
| S0082 | PH-002 | PH-002, an inhibitor of intracellular domain interaction of apolipoprotein E4 (ApoE4) in nerve cells. | ||
| E0792 | SW-106065 | SW-106065 is an apoptosis inducer in malignant peripheral nerve sheath tumors (MPNST), which can inhibit ATP consumption of sporadic MPNST and other models of MPNST with an EC50 of 1 µM. | ||
| E1272New | SRI-37330 HCl | SRI-37330 HCl(EX-A5854), an anti-diabetic drug, is an orally bioavailable inhibitor of thioredoxin-interacting protein (TXNIP), with an IC50 of 0.64 μM for TXNIP expression in INS-1 cells. Its treatment inhibits glucagon secretion and function, decreases hepatic glucose production, and reverses hepatic steatosis. | ||
| E1204 | NVP-DKY709 | NVP-DKY709 is a potent IKZF2 inhibitor for the treatment of cancers. | ||
| E1913New | MZ-101 | MZ-101 (GYS1-IN-2) is a potent small molecule inhibitor of Glycogen synthase 1(GYS1) with an IC50 value of 0.041 µM. By depleting muscle glycogen, MZ-101 treatment normalizes glycogen levels and corrects transcriptional and metabolic abnormalities in Pompe mice. | ||
| E1333 | wiskostatin | Wiskostatin is a potent and selective inhibitor of neuronal Wiskott-Aldrich syndrome protein (N-WASP)-mediated actin polymerization. Wiskostatin causes a rapid, profound, and irreversible decrease in cellular ATP levels. | ||
| S9460 | Ethotoin | Ethotoin (Peganone) is a hydantoin derivative and an orally active anticonvulsant agent. It also exerts an antiepileptic effect and can be used in epilepsy research. | ||
| E4275New | β-Aminopropionitrile | β-Aminopropionitrile (BAPN) is an orally active, specific, and irreversible inhibitor of lysyl oxidase (LOX). It targets the active site of LOX or LOXL isoenzymes. | ||
| E4734New | MeAIB | MeAIB (α-(Methylamino)isobutyric acid) is a specific substrate for amino acid transport system A, especially System A (ATA1). It also inhibits SNAT2, which reduces intracellular levels of essential amino acids and impairs cell proliferation in porcine enterocytes by disrupting the mTOR signalling pathway. | ||
| E4922New | Allopurinol riboside | Allopurinol riboside, a metabolite of allopurinol, competitively inhibits the action of purine nucleoside phosphorylase on inosine in vitro with a Ki value of 277 μM. It displays potent activities against parasites. | ||
| S3529 | Linerixibat | Linerixibat (GSK 2330672, GSK 672), a highly potent, nonabsorbable inhibitor of apical sodium dependent bile acid transporter (ABST), also known as the ileal bile acid transporter (IBAT), is used to the treatment of cholestatic pruritus in primary biliary Cholangitis. The IC50 of human ASBT is 42 nM. | ||
| E5772New | DC_AC50 | DC_AC50 is an inhibitor of the copper-trafficking proteins Atox1 (kd ∼6.8 µM) and full-length CCS (kd ∼8.2 µM) that significantly suppressing cell proliferation in various human cancer cell lines. | ||
| E6033New | Cilastatin sodium | Cilastatin sodium (MK0791 sodium) is a reversible, competitive inhibitor of renal dehydropeptidase I (also known as membrane dipeptidase, MDP), with an IC50 of 0.1 µM. It is primarily used in combination with imipenem to enhance the antibiotic's effectiveness against a broad spectrum of bacterial infections by preventing its degradation in the kidneys. | ||
| S2422 | Ipriflavone (Osteofix) | Ipriflavone (7-Isopropoxyisoflavon) is used to inhibit bone resorption. | ||
| E0428New | IMP-1088 | IMP-1088 is a potent dual inhibitor of human N-myristoyltransferases NMT1 and NMT2, with an IC50 of <1 nM for HsNMT1 and HsNMT2 and a Kd of <210 pM for HsNMT1. It effectively inhibits the production of infectious rhinovirus virions by blocking the N-myristoylation of the rhinovirus VP0 protein. | ||
| E0752 | Paederoside | Paederoside is a monoterpene S-methyl thiocarbonate isolated from Paederia pertomentosa and inhibits Epstein-Barr virus (EBV) early antigen (EA). | ||
| E1951New | X5050 | X5050 is a benzoimidazole-5-carboxamide derivative and a potent inhibitor of repressor element-1 silencing transcription factor (REST) with an EC50 of 2.1 μM. It can be used in research of Huntington's disease and other neurodegenerative disorders characterized by altered BDNF levels. | ||
| E1317New | LY 345899 | LY345899 is a Folate analog and a potent inbhibitor of methylene tetrahydrofolate dehydrogenase1 (MTHFD1; DC301) and methylene tetrahydrofolate dehydrogenase2 (MTHFD2) with IC50 values of 96 nM and 663 nM, respectively. It significantly suppresses tumor growth and reduces tumor weight in CRC patient-derived xenograft models. | ||
| S6566 | NSC23005 Sodium | NSC 23005 is a small molecule inhibitor of p18 (ED50=5.21 nM). | ||
| S8145New | Plicamycin | Plicamycin (Mithramycin A) a selective inhibitor of Sp1, is a natural polycyclic aromatic polyketide isolated from Streptomyces strains. It binds to GC-rich DNA sequences, displacing Sp1 transcription factor from oncogene promoters, inhibiting their expression, with anti-tumor and neuroprotective effects. | ||
| E0649 | ADAMTS-5 Inhibitor | ADAMTS-5 Inhibitor is a potent ADAMTS-5 (aggrecanase-2) inhibitor, with an IC50 of 1.1 µM. | ||
| S0801 | Spastazoline | Spastazoline is a potent, cell-permeable and selective spastin (a microtubule-severing AAA (ATPases associated with diverse cellular activities) protein) inhibitor with IC50 of 99 nM for Human spastin. Spastazoline does not inhibit ATPase activity of a recombinant human VPS4 (another AAA protein required for intercellular bridge disassembly). | ||
| E4312 | CSRM617 hydrochloride | CSRM617 hydrochloride is a selective small-molecule inhibitor of the transcription factor ONECUT2 (OC2, a master regulator of androgen receptor) with a Kd of 7.43 uM in SPR assays, binding to OC2-HOX domain directly. It induces apoptosis by appearance of cleaved Caspase-3 and PARP and is well tolerated in the prostate cancer mouse model. | ||
| S3337 | L-Histidinol dihydrochloride | L-Histidinol dihydrochloride, a structural analogue of the essential amino acid L-histidine, is a reversible inhibitor of protein biosynthesis which evokes disparate responses from non-tumorigenic and tumorigenic cells in culture. |
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| E4610New | SMIP34 | SMIP34 is a small molecule inhibitor of proline, glutamic acid, and leucine-rich protein 1 (PELP1). It is effective in reducing cell viability, reducing invasion, and inducing apoptosis in Triple-negative breast cancer (TNBC) models. | ||
| S9787 | Conoidin A | Conoidin A is a covalent inhibitor of peroxiredoxin II with an IC50 of 25.1 mM for recombinant T. gondii enzyme peroxiredoxin II (rTgPrxII). | ||
| S0792New | Varoglutamstat | Varoglutamstat (PQ912) is an inhibitor of glutaminyl cyclase (QC), inhibiting human glutaminyl cyclase (hQC) activity with a Ki of 25 nM (pH 8.0). It reduces pyroglutamyl-Aβ (pE-Aβ) levels and can be used in Alzheimer's disease research. | ||
| E0621 | FGFR1/DDR2 inhibitor 1 | FGFR1/DDR2 inhibitor 1 is an inhibitor of fibroblast growth factor receptor 1 (FGFR1) and discoidin domain receptor 2 (DDR2). | ||
| S3096 | L-Histidine monohydrochloride monohydrate | L-Histidine monohydrochloride monohydrate (L-Histidine hydrochloride hydrate, H-His-OH.HCl.H2O), a structural analogue of the essential amino acid L-histidine, is a reversible inhibitor of protein biosynthesis which evokes disparate responses from non-tumorigenic and tumorigenic cells in culture. |
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| E2907 | 1-Thioglycerol | 1-Thioglycerol(Mercaptopropanedioltech) is an inhibitor of glycerol kinase activity. It stimulates the synthesis of porphyrin in aerobically growing Escherichia coli. | ||
| S3547 | Bractoppin | Bractoppin, a drug-like inhibitor of phosphopeptide recognition by the human BRCA1 tandem (t)BRCT domain, which selectively inhibits substrate binding with nanomolar activity (IC50 = 0.074 μM) in vitro. | ||
| S6420 | AGI 1067 | AGI-1067 is a novel, phenolic, intra- and extracellular antioxidant that inhibits the expression of a number of proinflammatory genes involved in atherosclerosis. | ||
| S0123New | Roflumilast N-oxide | Roflumilast N-oxide is an inhibitor of PDE type 4. | ||
| S7407New | NFAT Inhibitor | NFAT Inhibitor (VIVIT peptide) is a selective inhibitor of nuclear factor of activated Tcells (NFAT) activation that effectively blocks calcineurin-mediated dephosphorylation of NFAT in cell extracts. It also serves as a valuable tool for the direct identification of NFAT target genes across various cell types. | ||
| S5442 | DL-2-Aminoadipic acid | DL-2-Aminoadipic acid is an excitatory amino acid analogue, which functions as a glutamine synthetase inhibitor. | ||
| S6558 | Irosustat (BN83495) | Irosustat (STX64, BN83495), a tricyclic coumarin sulfamate, is an orally active, nonsteroid-based, irreversible steroid sulfatase inhibitor with an IC50 of 8 nM. | ||
| E0112 | INH154 | INH154 is a potent inhibitor of Nek2 and Hec1 binding. NH154 binds to Hec1, thus blocking Hec1 phosphorylation by NEK2, and kills cancer cells at the nanomolar range. | ||
| E1183 | MRTX0902 | MRTX0902 is a potent SOS1 inhibitor for therapeutic intervention of KRAS-driven cancers with an IC50 of 46 nM. | ||
| E0636 | GSK-1520489A | GSK-1520489A(EX-A5430) is an active Protein Kinase, Membrane Associated Tyrosine/Threonine 1 (PKMYT1) inhibitor. | ||
| S4264 | Etofibrate | Etofibrate is a combination of clofibrate and niacin, used to treat hyperlipemia. | ||
| E0305 | UNC 3230 | UNC3230 is a potent, selective and ATP-competitive PIP5K1C inhibitor with an IC50 of ~41 nM and also inhibits PIP4K2C . It also has antinociceptive and anticancer effects. | ||
| E1795New | Triparanol(MER-29) | Triparanol (MER-29) is an inhibitor of 24-dehydrocholesterol reductase (DHCR24), an enzyme involved in cholesterol biosynthesis. It exhibits antitumor properties, such as decreasing proliferation and inducing apoptosis in various cancer cell lines, while also reducing Hedgehog pathway signaling in these cells. | ||
| E1628New | BMS-911172 | BMS-911172 is a brain penetrant, selective inhibitor of adaptor protein 2-associated kinase 1 (AAK1) with an IC50 value of 12 nM. BMS-911172 inhibits μ2 phosphorylation and has potential as a therapeutic agent in neuropathic pain research. | ||
| E0082 | R59949 | R59949, a diacylglycerol kinase (DGK) inhibitor with an IC50 of 300 nM, inhibits inducible nitric oxide production through decreasing transplasmalemmal L-arginine uptake in vascular smooth muscle cells. R59949 strongly inhibits type I DGK a and γ, and moderately attenuates type II DGK θ and κ. | ||
| S0150 | ML239 | ML239 is a potent and selective inhibitor of breast cancer stem cells, with an IC50 of 1.16 μM, with ~24-fold selectivity against the control cell line. | ||
| E1185 | SR-0813 | SR-0813 is a potent and selective ENL/AF9 YEATS domain inhibitor. SR-0813 has IC50 values of 25 and 311 nM for ENL YEATS domain and AF9 YEATS domain, respectively. | ||
| E1175 | RP-6306 | RP-6306 is a Protein Kinase, Membrane Associated Tyrosine/Threonine 1 (PKMYT1) inhibitor, which can be used for the research of cancer. | ||
| E1221 | CIA1 | CIA 1 (COUP-TFII inhibitor A1) is a specific inhibitor of the nuclear receptor COUP-TFII with IC50 of 1.2 μM to 7.6 μM in prostate cancer cell lines. | ||
| S8756 | XRK3F2 | XRK3F2 is an inhibitor of the p62-ZZ domain that blunts MM-induced Runx2 suppression in vitro, and induces new bone formation and remodeling in the presence of tumor in vivo. | ||
| E4732New | FDW028 | FDW028 is a highly potent and selective inhibitor of FUT8. FDW028 demonstrates strong anti-tumor effects by promoting defucosylation and inducing lysosomal degradation of B7-H3 via the chaperone-mediated autophagy (CMA) pathway. Additionally, FDW028 suppresses the AKT/mTOR signaling pathway. FDW028 exhibits potent anti-Metastatic colorectal cancer (mCRC) activities. | ||
| E1896New | BMS-502 | BMS-502 is a potent dual inhibitor of diacylglycerol kinase (DGK) α and ζ with IC50 values of 4.6 nM and 2.1 nM, respectively. BMS-502 also exhibits an EC50 value of 340 nM in the mouse cytotoxic T cell IFN-γ assay (mCTC). BMS-502 can be used in tumor immunity-related research. | ||
| E2932 | SI-2 Hydrochloride | SI-2 hydrochloride (EPH 116 hydrochloride) is an inhibitor of Steroid receptor coactivator 3 (SRC-3), with IC50 of 3–20 nM, it can significantly inhibit breast tumor growth. | ||
| S6679 | C25-140 | C25-140 is a small-molecule inhibitor of TRAF6-Ubc13 interaction. C25-140 directly binds to TRAF6, thereby blocking the interaction of TRAF6 with Ubc13, and as a consequence lowers TRAF6 activity. C25-140 impedes NF-κB activation in various immune and inflammatory signaling pathways also in primary human and murine cells. | ||
| S6200 | Elsulfavirine | Elsulfavirine (Elpida, VM-1500) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) developed for the treatment and prevention of HIV-1 infection. | ||
| E0509 | chinifur | Chinifur, a selective inhibitor and "subversive substrate" for Trypanosoma congolense trypanothione reductase. | ||
| E1948New | ZT-1a | ZT-1a is a potent and selective, non-ATP-competitive inhibitor of STE20/SPS1-related proline-alanine-rich kinase (SPAK) with an IC50 of 44.3 μM. It can exhibit therapeutic potential for brain disorders linked to impaired ionic homeostasis in research. | ||
| S3187 | SBI-477 | SBI-477 is an insulin signaling inhibitor that deactivates the transcription factor MondoA, leading to reduced expression of the insulin pathway suppressors thioredoxin-interacting protein (TXNIP) and arrestin domain-containing 4 (ARRDC4). SBI-477 inhibits triacylglyceride (TAG) synthesis and enhances basal glucose uptake in human skeletal myocytes. | ||
| E0029 | Hexa-D-arginine | Hexa-D-arginine is a potent and specific furin inhibitor with Ki values of 106 nM, 580 nM, and 13.2 μm for furin, PACE4, and PC1, respectively. | ||
| E4716New | QS11 | QS11 acts as an inhibitor of ARFGAP1 (ADP-ribosylation factor GTPase-activating protein 1), with an EC50 of 1.5 μM. QS11 regulates Wnt/β-catenin signaling by interacting with ARF GTPase-activating protein 1 (ARFGAP1) and influences protein trafficking. Additionally, QS11 suppresses the migration of breast cancer cells that overexpress ARFGAP1. | ||
| D4004 | Patritumab deruxtecan | Patritumab deruxtecan (HER3-DXd) is an antibody-drug conjugate (ADC) composed of a fully human anti-HER3 IgG1 monoclonal antibody and a cytotixic topoisomerase I inhibitor. Patritumab deruxtecan shows anticancer activity. | ||
| E4997New | BAY 2927088（Sevabertinib） | BAY 2927088（Sevabertinib) is the first non-covalent, potent, oral, selective, and reversible inhibitor of tyrosine kinase that potently inhibits mutant HER2 and mutant EGFR in preclinical models. It targets Exon 20 insertions in non-small-cell lung carcinoma (NSCLC) patients. | ||
| S9677 | NCGC00378430 | NCGC00378430 is an inhibitor of the SIX1/EYA2 complex that significantly suppresses breast cancer-associated metastasis in vivo without significantly altering primary tumor growth. | ||
| S4465 | VPC-80051 | VPC-80051 is an potent inhibitor of hnRNP A1 splicing activity that targets hnRNP A1 RBD and reduces AR-V7 messenger levels in 22Rv1 CRPC cell line. | ||
| E1798New | HOIPIN-8 | HOIPIN-8, is a potent inhibitor of linear ubiquitin chain assembly complex (LUBAC) and NF-κB signaling with an IC50 value of 11 nM. It serves as a powerful tool for investigating the physiological and cellular functions of LUBAC. | ||
| E1637New | ALKBH5 inhibitor 1 (compound 3) | ALKBH5 inhibitor 1 (compound 3) is an inhibitor of the RNA m6A Demethylase ALKBH5, with an IC50 value of 0.84 μM. It also exhibits potent antiproliferative activity. | ||
| S4233 | Zoxazolamine | Zoxazolamine (NSC 24995, Contrazole) is a centrally acting myorelaxant, which is formerly used as an antispasmodic and uricosuric. | ||
| S3351 | Sodium phenylpyruvate | Sodium phenylpyruvate (Phenylpyruvic acid sodium salt) inhibits amino acid formation and depresses oxygen consumption. | ||
| D4007 | Clivatuzumab-MMAE | Clivatuzumab-MMAE is an antibody-drug conjugate (ADC) composed of a humanized anti-mucin (MUC1) monoclonal antibody and a anti-mitotic cytotoxic agent monomethyl auristatin (MMAE). | ||
| E0832 | Compound 10w | Compound 10w, a substituted pyrazolo [1,5-a] pyrimidine amide derivative, shows good anticancer activity against HeLa cell line, with IC50 of less than 10 µM against HeLa cell. | ||
| D4015 | Farletuzumab-MMAE | Farletuzumab-MMAE is an antibody-drug conjugate (ADC) composed of humanized anti-human folate receptor-alpha (FRα) and the cytotoxic agent monomethyl auristatin (MMAE) via a MC-Vc linker. It has a potent antitumor activity. | ||
| E1264New | VIT-2763 | VIT-2763 is an oral small-molecule inhibitor of ferroportin. It displaces TMR-hepcidin from ferroportin with an IC50 of 24 nM. It also ameliorates anemia, enhances erythropoiesis, and reduces organ iron loading in the Hbbth3/+ β-thalassemia intermedia disease model. | ||
| E1910New | TASIN-30 | TASIN-30 is a selective inhibitor of Emopamil binding protein (EBP) with EC50 values of 0.097 μM for EBP competition, respectively. TASIN-30 displays selectivity for EBP over DHCR24. | ||
| E1800New | Oxythiamine chloride hydrochloride | Oxythiamine chloride hydrochloride(Hydroxythiamine chloride hydrochloride) is a salt form of Oxythiamine. It is an inhibitor of transketolase, the enzyme that controls the nonoxidative branch of the pentose phosphate pathway. It also suppresses tumor cell proliferation and promotes apoptosis. | ||
| E1684 | C1632 | C1632 (Lin28-let-7 antagonist 1) is a RNA-binding protein and a potent antagonist of Lin28/pre-let-7 interaction. It inhibits Lin28A binding to pre-let-7a-2, with an IC50 of 8 μM as well as inhibits proliferation in human cancer cells. | ||
| S0886 | SC-26196 | SC-26196 is a potent, orally active Delta6 desaturase (D6D, FADS2) inhibitor with an IC50 of 200nM. | ||
| S2971 | SIBA | SIBA (5′-Isobutylthio-5′-deoxyadenosine, 5'-Deoxy-5'-isobutylthioadenosine, 5'-Isobutylthioadenosine) is a synthetic analogue of S-adenosylhomocysteine and is a powerful antipro-liferative drug. SIBA is not only an inhibitor of transmethylation but also interferes with polyamine biosynthesis, probably by blocking aminopropyltransferase. | ||
| E1536New | (R)-HTS-3 (GLXC-25878) | (R)-HTS-3 (GLXC-25878) is a potent, selective, and cell-active inhibitor of lysophosphatidylcholine acyltransferase 3 (LPCAT3) with an IC50 of 0.09 µM, an enzyme critical for synthesizing C20:4-containing phospholipids. It reduces arachidonic acid-d8 incorporation into phospholipids and mitigates RSL3-induced ferroptosis in HT-1080 and 786-O cancer cells. | ||
| E8033New | DO-264 | DO-264 is a potent, selective, and in vivo-active inhibitor of ABHD12, a lysophospholipid hydrolase enzyme, with an IC50 of 11 nM. It dose-dependently increases levels of lysophosphatidylserine (lyso-PS) and 20:4 phosphatidylserine (20:4 PS) in brain tissue. It also enhances immunological responses in lymphocytic choriomeningitis virus (LCMV) infection. | ||
| S2973 | SEC inhibitor KL-1 | SEC inhibitor KL-1 (KL-1) is a potent and selective inhibitor of super elongation complex (SEC) that disrupts the interaction between the SEC scaffolding protein AFF4 and P-TEFb, resulting in impaired release of Pol II from promoter-proximal pause sites and a reduced average rate of processive transcription elongation. KL-1 exhibits an dose-dependent inhibitory effect on AFF4-CCNT1 interaction with Ki of 3.48 μM. | ||
| E1636 | MV1035 | MV1035, an inhibitor of ALKBH5 significantly reduces GBM U87-MG cell migration and invasiveness through inhibition of the RNA demethylase ALKBH5. | ||
| E0184 | 2-Mercaptobenzothiazole | 2-Mercaptobenzothiazole (Benzothiazole-2-thiol, 2-MBT, Mercapto-2-benzothiazole) is an exceptionally potent inhibitor of banana polyphenoloxidase and can significantly delay the onset of substrate oxidation at concentrations as low as 100 nM. | ||
| E1074 | MM3122 | MM3122 is a selective inhibitor of host cell serine protease TMPRSS2 (transmembrane protease serine 2) with IC50 of 0.34 nM against recombinant full-length TMPRSS2 protein. | ||
| E1028 | POMHEX | POMHEX, is a potent ENO2 -specific inhibitor of enolase and a racemic mixture, a cell-permeable pivaloyloxymethyl (POM) prodrug of HEX. It is also glycolysis inhibitor and can be used for the research of cancer. | ||
| E1037 | ZZW-115 | ZZW-115 is a potent NUPR1 inhibitor with IC50s of 0.42 μM in Hep2G cells and 7.75 μM in SaOS-2 cells. ZZW-115 shows evident antitumor activity through its interaction with NUPR1. | ||
| S5434 | AS057278 | AS057278 (3-Methylpyrazole-5-carboxylic acid, MPC) is an inhibitor of D-amino acid oxidase (DAAO). | ||
| E4941New | Diflorasone diacetate | Diflorasone diacetate(Florone), is a steroid anti-inflammatory drug, an inhibitor of TARC (thymus and activation regulated chemokine; CCL17) in the dinitrochlorobenzene (DNCB) model. It can be used in the treatment of allergic and inflammatory skin diseases such as atopic dermatitis and allergic contact dermatitis. | ||
| S0857 | BLT-1 | BLT-1(Block lipid transport-1), a thiosemicarbazone copper chelator, is a selective inhibitor of HDL receptor (scavenger receptor B, type 1 - SR-BI). BLT-1 inhibits the transfer of lipids between HDL and cells mediated by SR-BI. | ||
| S6801 | AKOS B018304 | AKOS B018304 (C6;NSC 43396) is an arylalkylidene derivative with a polar substitution at the para-position. It functions as an inhibitor of ΔFosB by allosterically inhibiting its binding to DNA. It disrupts ΔFosB binding to TMR-cdk5 with an IC50 value of 10.1 μM and also induces a structural change in ΔFosB that prevents the protein from binding to DNA. | ||
| S9152 | Epiberberine | Epiberberine, a natural protoberberine alkaloid, is a potent inhibitor against both ureases with IC50 values of 3.0±0.01μM for HPU (ureases from Helicobacter pylori) and 2.3±0.01μM for JBU (ureases from jack bean). | ||
| E4666New | O-Propargyl-Puromycin | O-Propargyl-Puromycin (OP-puro) is an alkyne puroanalog, a potent inhibitor of protein synthesis . It is used to label nascent proteins in whole animals, allowing the visualization of protein synthesis patterns in large explants from tissues and organs. | ||
| E2815 | Lalistat 2 | Lalistat 2 is a specific inhibitor of lysosomal acid lipase (LAL) which allows the determination of LAL in dried blood spots (DBS). | ||
| E1538 | PRGL493 | PRGL493 is a potent and selective inhibitor of long-chain acyl-CoA synthetase 4 (ACSL4). PRGL493 blocks cell proliferation and tumor growth in both breast and prostate cellular and animal models. PRGL493 is used for cancer research. | ||
| E1080 | HG106 | HG106, a potent SLC7A11 inhibitor, leads to enhanced ROS generation, ER stress, and ultimately growth arrest specifically in KRAS-mutant lung adenocarcinoma (LUAD). | ||
| S7814 | AI-10-49 | AI-10-49 is a selective inhibitor of the binding of CBFβ-SMMHC to RUNX1 with IC50 of 260 nM. | ||
| S9494 | Darutigenol | Darutigenol has antithrombotic effect and may be related to inhibition of platelet aggregation and adhesion. | ||
| E1275 | FR054 | FR054 is a novel inhibitor of the Hexosamine Biosynthetic Pathway (HBP) enzyme PGM3 with a remarkable anti-breast cancer effect. | ||
| E1245 | Ro5-3335 | Ro5-3335 is an inhibitor of Core binding factor leukemia (CBF leukemia), by interacting with RUNX1 and CBFβ directly, repressing RUNX1/CBFB-dependent transactivation and runx1-dependent hematopoiesis. | ||
| E2694 | D-Saccharic acid 1,4-lactone monohydrate | D-Saccharic acid 1,4-lactone monohydrate is a potent β-glucuronidase inhibitor with an IC50 of 48.4 μM. | ||
| S5084 | Carbazochrome | Carbazochrome (Adedolon, Adchnon, Adrenostazin, Cromadrenal, Adona, AC-17) is a hemostatic agent that causes the aggregation and adhesion of platelets in the blood to form a platelet plug, ceasing blood flow from an open wound. | ||
| E4785New | BAP1-IN-1 | BAP1-IN-1 is a small-molecule inhibitor of BRCA1 associated protein 1 (BAP1) catalytic activity in vitro with an IC50 of 0.1-1 μM. It exhibits a potential therapeutic target for leukemia. | ||
| S5688 | Tropolone (NSC 89303) | Tropolone (NSC 89303, 2-Hydroxytropone, Purpurocatechol), a metal chelator, possesses weak antioxidative and radical-scavenging properties and shows a strong affinity for ferric ion. It is able to inhibit ferric iron reduction by catecholates, lowering the redox potential of the iron couple. | ||
| E2852 | BC-1471 | BC-1471, a small-molecule inhibitor of STAM-binding protein (STAMBP) deubiquitinase activity, decreases NACHT, LRR and PYD domains-containing protein 7 (NALP7) protein levels and suppresses IL-1β release after TLR agonism. | ||
| E1388 | ISA-2011B | ISA-2011B is an inhibitor of phosphatidylinositol-4-phosphate 5-kinase-α (PIP5Kα). ISA-2011B exhibits anti-proliferative activity and induces apoptosis in prostate cancer cells. | ||
| S7478 | AF38469 | AF38469 is a selective, orally bioavailable Sortilin inhibitor with an IC50 value of 330 nM. | ||
| S6798 | ELN484228 | ELN484228 is a cell-permeable blocker that targets α-synuclein, a key protein in Parkinson’s disease. | ||
| E0145 | LOX-IN-3 Dihydrochloride | LOX-IN-3 Dihydrochloride is an orally active and selective lysyl oxidase (LOX) inhibitor. | ||
| E1810 | dCeMM1 | dCeMM1 is a degrader of RBM39. dCeMM1 functions by altering the activity of the CRL4DCAF15 ligase, and also decreases RBM39 expression levels in wild-type KBM7 cells. | ||
| S3285 | Dihydrolycorine | Dihydrolycorine is a derivative of lycorine, an alkaloid isolated from Lycoris radiata Herb. Dihydrolycorine blocks protein synthesis in ascites cells and stabilize HeLa cell polysomes in vivo. Dihydrolycorine exhibits antihypertensive and neuroprotective activities. | ||
| A2116 | Rat IgG2b isotype control-InVivo | Rat IgG2b isotype control-InVivo monoclonal antibody (Clone:LTF-2) reacts with keyhole limpet hemocyanin (KLH). Because KLH is not expressed by mammals this antibody is ideal for use as an isotype-matched control for rat IgG2b antibodies in most in vivo and in vitro applications. |
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| A2119 | Rat IgG1 isotype control-InVivo | Rat IgG1 isotype control-InVivo monoclonal antibody (Clone:HRPN) reacts with horseradish peroxidase (HRP). Because HRP is not expressed by mammals this antibody is ideal for use as an isotype-matched control for rat IgG1 antibodies in most in vivo and in vitro applications. |
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| A2031 | Sacituzumab (anti-Trop-2) | Sacituzumab (anti-Trop-2) is a fully humanized IgG1 kappa monoclonal antibody that binds Trop-2. | ||
| A2129 | Anti-mouse Thy1.2 (CD90.2)-InVivo | Anti-mouse Thy1.2 (CD90.2)-InVivo(clone 30H12) is a monoclonal antibody reacts with mouse Thy1.2 also known as CD90.2. It induces Ca2+ flux in thymocytes and is particularly useful for depleting T lymphocytes. | ||
| A2117 | Mouse IgG2a isotype control-InVivo | Mouse IgG2a isotype control-InVivo (Clone:C1.18.4) monoclonal antibody is ideal for use as a non-reactive isotype-matched control for mouse IgG2a antibodies in most in vivo and in vitro applications. | ||
| A2169New | Anti-mouse MHC Class II (I-A/I-E)-InVivo | |||
| A2170New | Anti-mouse CSF1-InVivo | |||
| A2042 | Pamrevlumab (anti-CTGF) | Pamrevlumab, a recombinant human antibody that binds to connective tissue growth factor (CTGF) has emerged as a potential therapy for idiopathic pulmonary fibrosis (IPF). |
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| A4061New | Emicizumab (Anti-Factor IX & Factor X) | Emicizumab is a recombinant, humanized, bispecific antibody that binds Factor IXa and Factor X to mimic Factor VIII function. It is used to treat hemophilia A. M.W 146.82 kDa | ||
| S9819 | C75 | C75 (4-Methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid) , a more stable synthetic mimic of cerulenin, inhibits fatty-acid synthase (FAS/FASN) with an IC50 of 15.53 μM and has potential therapeutic effects in several cancer models. C75 is also a potent CPT1A activator. | ||
| S1024 | LTI-291 | LTI-291 is the first small-molecule activator of Glucocerebrosidase(GCase) for the treatment of parkinson's disease. | ||
| E2389 | ML-098 | ML-098 is an activator of the GTP-binding protein Rab7 with an EC50 of 77.62 nM. | ||
| S3381 | VUT-MK142 | VUT-MK142 is a potent new cardiomyogenic synthetic agent promoting the differentiation of pre-cardiac mesoderm into cardiomyocytes, which may be useful to differentiate stem cells into cardiomyocytes for cardiac repair. | ||
| E4728New | VVD-130037(BAY-3605349) | VVD-130037(BAY-3605349) is an orally available covalent small molecule activator of Kelch-like ECH associated protein 1 (KEAP1), which provide enhanced cellular degradation of nuclear factor-erythroid 2 p45-related factor 2 (NRF2) resulting in significant inhibition of tumor growth in advanced solid tumors. | ||
| S6615 | ATB 346 | ATB 346, a novel hydrogen sulphide-releasing derivative of naproxen with remarkably reduced toxicity, inhibits COX activity. ATB 346 is an anti-inflammatory agent that induces apoptosis of human melanoma cells. | ||
| E1332 | EG-011 | EG-011 is a potent Wiskott-Aldrich syndrome protein (WASP) activator. | ||
| S3538 | CEBPα inducer 1 | C/EBPα inducer 1 (compound 78) is a potent inducer of CCAAT enhancer-binding protein α (C/EBPα) and myeloid differentiation. | ||
| S9093 | Nardosinone | Nardosinone, isolated from Nardostachys root, an important Chinese herbal medicine, is an enhancer of nerve growth factor and possesses a wide range of pharmacological effects, including sedative, adaptogen-like, anti-depressive, anti-leukemic, anti-tumorous, and anti-trypanosomal activities. | ||
| S5091 | Geranyl acetate | Geranyl acetate (Geraniol acetate, Geranyl ethanoate) is a natural organic compound that is used primarily as a component of perfumes for creams and soaps and as a flavoring ingredient. | ||
| S0196 | Tirasemtiv (CK-2017357) | Tirasemtiv (CK-2017357, CK-357) is a direct fast skeletal muscle troponin activator that sensitizes the sarcomere to calcium. | ||
| S0447 | ASP7663 | ASP7663 is an orally bioavailable selective activator of transient receptor potential ankyrin 1 (TRPA1). ASP7663 activates human, rat and mouse TRPA1 receptors with EC50 of 510 nM, 540 nM and 500 nM, respectively. ASP7663 acts by stimulating 5-HT release from QGP-1 cells and exhibiting an abdominal analgesic effect in vivo. | ||
| S9943 | ErSO | ErSO activates the unfolded protein response (UPR) with an IC50 of 20.3 nM in MCF-7 cells. ErSO induces rapid and selective necrosis of ERα-positive breast cancer cell lines in vitro. | ||
| S0502 | SR8278 | SR8278 is a competitive antagonist of nuclear heme receptor REV-ERB with an EC50 of 0.47 μM for REV-ERBα. | ||
| S0014 | HT-2157 | HT-2157 (SNAP37889) is a selective, high-affinity, competitive antagonist of galanin-3 receptor (Gal3). | ||
| E0401 | BI6015 | BI6015, a <b>hepatocyte nuclear factor 4α (HNF4α)</b> antagonist, induces loss of HNF4α expression and hepatic steatosis in vivo. BI6015 is cytotoxic to human hepatocellular carcinoma (HCC). |
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| P1239New | ADH-1 | ADH-1, an antagonist of N-cadherin, blocks N-cadherin-mediated cell adhesion. It exhibits significant antitumor activity against N-cadherin-expressing cells in vitro assays. | ||
| E4936New | Larazotide acetate | Larazotide acetate(AT-1001), a synthetic peptide, is an antagonist of zonulin. It functions as a gut permeability regulator for the treatment of celiac disease. | ||
| E2035 | Larazotide | Larazotide(AT-1001) is an antagonist of Zonulin, which appears safe and well-tolerated and may offer potential benefit as an adjuvant to immune-targeted therapies. | ||
| E1119 | EG00229 | EG00229 is a neuropilin 1 (NRP1) receptor antagonist with an IC50 of 3 μM against VEGF-A binding to NRP1 b1 domain. | ||
| E4636New | W-7 hydrochloride | W-7 hydrochloride is a potent antagonist of calmodulin (CaM) that inhibits Dengue virus (DENV) translation and replication. It also competitively inhibits Trypsin-treated Ca2+/calmodulin-dependent phosphodiesterase (Ca2+-PDE). It exhibits anti-proliferative and anti-tumor effect. | ||
| S6788 | PEO-IAA | PEO-IAA (2-(1H-Indol-3-yl)-4-oxo-4-phenyl-butyric acid) is a novel potent auxin antagonist that binds to transport inhibitor response 1/auxin signaling F-box proteins (TIR1/AFBs). PEO-IAA suppresses not only the expression of an auxin-responsive ZmSAUR2 gene, but also gravitropic curvature. | ||
| E1616New | AZD8797( KAND567) | AZD8797 (KAND567) is an allosteric, non-competitive, and orally active antagonist of the human receptor CX3CR1. It antagonizes CX3CR1 with a Ki value of 3.9 nM, respectively. It effects G-protein signaling and β-arrestin recruitment. | ||
| S3107 | D-Pyroglutamic acid | D-Pyroglutamic acid (D-5-Oxoproline, D-Pyr-OH, 5-oxo-D-proline, (R)-5-Oxopyrrolidine-2-carboxylic acid) is an active endogenous metabolite that antagonizes the disruption of passive avoidance behaviour induced by the N-methyl-D-aspartate receptor antagonist AP-5. |
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| E4637New | PK 11195 | PK 11195 (RP 52028) is a translocator protein (TSPO) ligand, a potent and selective antagonist of peripheral benzodiazepine receptorwith high affinity Ki of 3.1 nM in cerebellum and 4.1 nM in spinal cord. It is also an antagonist of human constitutive androstane receptor (hCAR), and human pregnane X receptor (PXR). It displaces [3H] RO5-4864 from its binding sites across organs and also targets Leishmania in chemotherapy. | ||
| S3415 | AA92593 | AA92593 is a selective antagonist of Melanopsin (OPN4) which is a photo-pigment found in a small subset of intrinsically photosensitive ganglion cells (ipRGCs) of the mammalian retina. | ||
| E4902New | Dantrolene | Dantrolene is an antagonist of ryanodine receptor (RYR) and a postsynaptic skeletal muscle relaxant that reduces calcium release from the sarcoplasmic reticulum (SR), leading to a dose-dependent decrease in myoplasmic free calcium levels. It is used to treat and control the accelerated hypermetabolism of skeletal muscle that leads to a malignant hyperthermia crisis. | ||
| S6960 | Auxinole | Auxinole is a potent auxin antagonist that binds to TIR1 and blocks the formation of the TIR1-IAA-Aux/IAA complex. Auxinole is an OsTIR1 inhibitor that suppresses leaky degradation of degron-fused proteins. | ||
| S6769 | Curcumin analog C1 | Curcumin analog C1 (Curcumin analog Compound C1) is a potent transcription factor EB (TFEB) activator with promise for the prevention or treatment of Alzheimer's disease. | ||
| S5182 | GSK4112 | GSK4112 is a functional Rev-erbα agonist with an EC50 of 0.4 μM. It represses the expression of gluconeogenic genes in liver cells and reduces glucose output in primary hepatocytes. | ||
| E1602 | Lotiglipron | Lotiglipron (PF-07081532) is an orally active GLP-1R agonist. It reduces glucose and body weight, and has the potential to be used in Type 2 diabetes mellitus (T2DM) research. | ||
| E1889New | PCO371 | PCO371 is a nonpeptidyl, orally active agonist of Parathyroid hormone type 1 receptor (PTHR1). It stimulates cAMP production in COS-7 cells with an EC50 of 2.4 μmol/L. It also acts as an osteoporosis drug and significantly enhances bone mineral density (BMD) and bone strength in the lumbar vertebrae of osteopenic ovariectomized (OVX) rats. It also restores normal serum calcium levels without increasing urinary calcium in hypocalcemic thyroparathyroidectomized (TPTX) rats. | ||
| S0989 | ML-180 | ML-180 (SR1848) is a potent inverse agonist of orphan nuclear receptor NR5A2 (Liver receptor homologue-1, LRH1) with IC50 of 3.7 μM. ML-180 has the potential for LRH-1-dependent cancers. | ||
| E0620 | LIT-001 trifluoroacetate | LIT-001 trifluoroacetate(LIT-001 TFA) is the first nonpeptide oxytocin receptor (OXTR) agonist that improves social interaction in a mouse model of autism. | ||
| E2686 | Methoprene | Methoprene is a growth-regulating insecticide that manifests its toxicity to target organisms by acting as a juvenile hormone agonist. | ||
| E1256 | Ibotenic acid | Ibotenic acid((RS)-Ibotenic acid; DL-Ibotenic acid) is a neuroexcitatory amino acid originally isolated from Amanita species. It exhibits agonist activity at both N-methyl-D-aspartate (NMDA) and trans-ACPD) or metabolotropic quisqualate (Qm) receptor sites. | ||
| E7144New | PAR-4 Agonist Peptide, amide | PAR-4 Agonist Peptide, amide is a agonist of proteinase-activated receptor-4 (PAR-4) that provides antinociceptive effects in stress- and inflammation-induced hyperalgesia. It reduces visceral pain by activating PAR-4 receptors on colonic nerve terminals. | ||
| E1716 | SR9011 | SR9011 is a REV-ERBα/β agonist with IC50s of 790 nM and 560 nM for REV-ERBα and REV-ERBβ, respectively. It is specifically lethal to cancer cells and oncogene-induced senescent cells, including melanocytic naevi. | ||
| S2474 | Fabomotizole hydrochloride | Fabomotizole hydrochloride (Fabomotizole, CM346, CM346, Afobazol, Afobazole) exhibits anxiolytic and neuroprotective properties. Fabomotizole hydrochloride is a potent sigma1-receptor agonist with IC50 of 7.1 µM and Ki of 5.9 µM. | ||
| S6775 | TUG-891 | TUG-891 is a potent and selective agonist of the long chain free fatty acid (LCFA) receptor 4 (FFA4/GPR120), which demonstrates both potential opportunity and possible challenges to therapeutic agonism. | ||
| S1428 | Risedronate Sodium | Risedronate (NE 58095) sodium, a nitrogen-containing bisphosphonate, inhibits osteoclast-mediated bone resorption and modulates bone metabolism, used in the treatment of osteoporosis. | ||
| E1299 | Polybrene (Hexadimethrine Bromide) | Polybrene (Hexadimethrine bromide) is a cationic polymer which is widely used as supplement for retroviral and lentiviral transduction. | ||
| S0798 | PZ-2891 | PZ-2891 is a selective, orally active and brain-penetrant pantothenate kinase (PANK) modulator that acts as an orthosteric inhibitor at high concentrations and an allosteric activator at lower sub-saturating concentrations. PZ-2891 inhibits PANK with IC50 of 40.2 nM, 0.7 nM and 1.3 nM for hPANK1β, hPANK2, and hPANK3, respectively. | ||
| S6973 | TJ191 | TJ191 is a selective anti-cancer small molecule that targets low TβRIII-expressing malignant T-cell leukemia/lymphoma cells. | ||
| S0026 | GET-73 | GET-73(Gamma hydroxybutyric acid analogue,GET 73,GHB analogue), a γ-hydroxybutyrate (GHB) analog, shows a neuroprotective role against ethanol-induced neurotoxicity in primary cultures of rat hippocampal neurons. | ||
| E1184 | CFT7455 | CFT7455 is an orally active zinc finger transcription factors (IKZF1) (Ikaros) and IKZF3 (Aiolos) degrader. It binds with high affinity to the cereblon E3 ligase (Kd of 0.9 nM). It is used in the treatment of multiple myeloma & non-Hodgkin’s lymphoma. | ||
| S0533 | TLX agonist 1 | TLX agonist 1 (CCRP2, SUN23314) is a modulator of orphan nuclear receptor tailless (TLX, NR2E1) with EC50 of 1.0 μM and Kd of 650 nM. TLX agonist 1 (CCRP2, SUN23314) binds to recombinant TLX protein and enhances TLX transcriptional repressive activity. | ||
| E1995New | AZD-5462 | AZD-5462(Example 1) is a modulator of RXFP1, the cognate receptor for human relaxin, that belongs to the GPCR family 1c number. AZD-5462 exhibits anti-fibrotic and anti-inflammatory properties. | ||
| S8540 | Voxelotor | Voxelotor is a novel small molecule hemoglobin modifier which increases hemoglobin oxygen affinity. | ||
| E1758New | Bersacapavir | Bersacapavir(JNJ-6379, JNJ-56136379) is a potent capsid assembly modulator (CAM) that accelerates capsid assembly and induces the formation of morphologically intact viral capsids devoid of genomic material. It inhibits HBV replication with an EC50 of 54 nM in HepG2.117 cells. | ||
| S7594 | Abscisic Acid (Dormin) | Abscisic Acid (Dormin, Abscisin II) is a plant hormone, which is involved in many plant developmental processes, modulates ion homeostasis and metabolism, and inhibits germination and seedling growth. | ||
| S9827 | Iodoacetamide | Iodoacetamide (IA, IAM, 2-Iodoacetamide) is an alkylating agent that is commonly used for alkylation of cysteine during sample preparation for proteomics. | ||
| S5937 | DL-Carnitine | DL-Carnitine ((±)-Carnitin) is a racemic mixture of L-Carnitine and D-Carnitine that regulates fatty acid transport in the mitochondrion. DL-carnitine is found to be ineffective or toxic, for example, to muscle cells and to the myocardium. DL-Carnitine causes symptoms of myasthenia and cardiac arrhythmias. | ||
| E0104 | Centhaquin | Centhaquin (Centhaquine, PMZ-2010), a potential agent for treatment of haemorrhagic shock, can augment cardiac output, reduce systemic vascular resistance in haemorrhagic models. | ||
| E0745 | AA147 | AA147, a small molecule endoplasmic reticulum (ER) proteostasis regulator, selectively activates ATF6 arm of the unfolded protein response (UPR) extracted from patent WO2017117430A1, compound 147*. | ||
| S5327 | Meisoindigo | Meisoindigo (N-Methylisoindigotin, Methylisoindigotin, Dian III), a derivative of Indigo naturalis, is an active compound of a Chinese anti-leukemia medicine that has been effectively used in the treatment of chronic myelogenous leukemia (CML). | ||
| E4889New | Glafenine | Glafenine (Glafenin) is a non-steroidal anti-inflammatory drug (NSAID) and is a non-narcotic analgesic agent that not only acts as a proteostasis modulator but is also one of the most potent NSAID correctors of F508del-CFTR. It exhibits COX-2 inhibition in the arachidonic acid pathway and rescues class 2 CFTR mutants. | ||
| S6712 | S107 | S107 is a Type 1 ryanodine receptor (RyR1) stabilizer that binds RyR1 and enhances the binding affinity of calstabin-1. | ||
| S6304 | KL001 | KL001 is a stabilizer that specifically interacts with cryptochrome (CRY). KL001 prevents ubiquitin-dependent degradation of CRY, resulting in lengthening of the circadian period. | ||
| S6782 | Anle138b | Anle138b is a novel oligomer modulator and an aggregation inhibitor, blocking the formation of pathological aggregates of prion protein (PrP(Sc)) and of α-synuclein (α-syn) with good oral bioavailability, blood-brain-barrier penetration and no detectable toxicity. Anle138b shows a new approach for disease-modifying therapy in neurodegenerative diseases such as prion and Parkinson's disease. | ||
| E1360New | BAY-069 | BAY-069 is a potent dual inhibitor of BCAT1/2 (branched-chain amino acid transaminases), with IC50 values of 31 nM for BCAT1 and 153 nM for BCAT2. It demonstrates high cellular activity, excellent selectivity, and is used as an in vitro probe. | ||
| E1915New | DDO-2728 | DDO-2728 is a selective pyrazolopyrimidine-based inhibitor of ALKBH5 with an IC50 of 2.97 μM. It increases the levels of N6-methyladenosine (m6A) modifications in acute myeloid leukemia (AML) cells and exhibits antiproliferative activity in these cells. It also demonstrates anti-tumor efficacy in the MV4−11 xenograft model. | ||
| E6003New | Gabapentin enacarbil | Gabapentin enacarbil (XP13512) is a prodrug of gabapentin, designed to enhance gabapentin absorption and bioavailability and treats restless legs syndrome. It also acts as an anticonvulsant and analgesic within the gabapentinoid class. | ||
| E7016New | Ac-DEVD-AFC | Ac-DEVD-AFC is a fluorogenic substrate specifically measures the activity of caspase-3, a key protease involved in apoptosis. | ||
| E1288New | Inaxaplin | Inaxaplin (VX-147) is an orally active inhibitor of apolipoprotein L1 (APOL1) function. Inaxaplin binds to APOL1 and is useful in the treatment of APOL1-associated kidney disease. | ||
| P1239New | ADH-1 | ADH-1, an antagonist of N-cadherin, blocks N-cadherin-mediated cell adhesion. It exhibits significant antitumor activity against N-cadherin-expressing cells in vitro assays. | ||
| E1966New | VVD-214 | VVD-214 (RO7589831, VVD-133214) is a synthetic allosteric inhibitor of WRN helicase. VVD-214 binds irreversibly to cysteine 727 on WRN, suppressing ATP hydrolysis and helicase activity. VVD-214 exhibits potent efficacy in inducing double-stranded DNA breaks, nuclear enlargement, and cellular apoptosis in cancers with high microsatellite instability (MSI). | ||
| E4936New | Larazotide acetate | Larazotide acetate(AT-1001), a synthetic peptide, is an antagonist of zonulin. It functions as a gut permeability regulator for the treatment of celiac disease. | ||
| E1908New | HRO761 | HRO761 is a potent, selective, allosteric inhibitor of Werner syndrome RecQ helicase (WRN). It binds at the interface of the D1 and D2 helicase domains, locking WRN in an inactive conformation, and demonstrates anti-proliferative effects specifically in microsatellite instability (MSI) cancer cells. | ||
| E1982New | SOP1812 | SOP1812( QN-302), is a tetra-substituted naphthalene diimide (ND) derivative and selective inhibitor of G-quadruplex (G4) transcription. It shows great affinity to hTERT G4 and HuTel21 G4 with KD values of 4.9 and 28.4 nM, respectively. It binds to G-quadruplex DNA in cancer gene promoters region and shows strong anti-proliferative and anti-tumor activity in pancreatic cancer models. | ||
| E1672New | NMDI14 | NMDI14(DA-66137) is an inhibitor of nonsense-mediated RNA decay (NMD). NMDI14 disrupts the SMG7-UPF1 interactions and inhibits NMD. NMDI14 increases the stability and expression of NMD targeted mRNAs. | ||
| E1788New | CQ211 | CQ211 is a cell penetrant, potent and selective inhibitor of RIOK2(Right open reading frame kinase 2) with a Kd of 6.1 nM. It effectively inhibits cancer cell proliferation and shows promising in vivo efficacy in mouse xenograft models. | ||
| E4592New | UGT8-IN-1 | UGT8-IN-1 is a brain-penetrable and orally active inhibitor of ceramide galactosyltransferase enzyme (UGT8). UGT8-IN-1 targets sulfatide metabolism resulting in ceramide-induced lethal mitophagy and subsequent cancer cell death in vitro, and reduces tumour growth in mutant Kras; Gnas allografts. | ||
| E4834New | 12-Crown-4 | 12-crown-4(EOCT, Ethylene oxide cyclic tetramer) is an effective phase-transfer catalyst and complexing agent for lithium, facilitating the dissolution of lithium bis(trifluoromethanesulfonyl)imide (LiTFSI) without requiring acetonitrile. It selectively binds to lithium ions and forms stable complexes, significantly improving electrolyte conductivity in lithium batteries, and positively influencing ion mobility and overall battery performance. | ||
| E4990New | 1-Butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide | 1-Butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide (BMIM TFSI) is a room-temperature ionic liquid with excellent ionic conductivity. Its solvation dynamics and conductivity are affected by proton concentration, which influences its performance in electrochemical applications. | ||
| E4940New | Chlorphenesin carbamate | Chlorphenesin carbamate(Maolate, Rinlaxer, U 19646) is a centrally-acting muscle relaxant that inhibits motoneuron excitability. It is also used to treat pain and discomfort related to skeletal muscle trauma and inflammation. | ||
| E4829New | Bismuth subnitrate | Bismuth subnitrate is an antigastric ulcer and antidiarrheic agent that induces metallothionein (MT). It can be used as an adjunct in cancer chemotherapy to induce MT in target organs. | ||
| E4826New | L-Ornithine L-aspartate | L-ornithine-L-aspartate (LOLA) is a stable salt composed of two natural nonessential L-amino acids: ornithine and aspartic acid. It effectively lowers blood ammonia concentration by enhancing ammonia detoxification in the muscles, and alleviating hepatic encephalopathy symptoms in liver cirrhosis. | ||
| E4832New | DL-Alanine | DL-alanine (DL-2-Aminopropionic acid) is a racemic mixture of L- and D-alanine that forms complexes with transition metals like Cu(II), Zn(II), and Cd(II). It also plays a key role in the glucose-alanine cycle between tissues and the liver. | ||
| E1947New | DiR (Cy7 DiC18) | DiR (Cy7 DiC18) is a near-infrared fluorescent long-chain carbocyanine dye used for labeling cell membranes, organelles, liposomes, viruses, and lipoproteins in vivo and in vitro. | ||
| E4830New | Guanidine thiocyanate | Guanidine thiocyanate is a potent inhibitor of nucleases and a powerful denaturant of proteins. It is used for RNA isolation due to its strong chaotropic properties, which effectively denature RNase enzymes in samples, ensuring RNA stability and purity during extraction processes. Nucleic acid extraction buffers containing guanidine thiocyanate effectively deactivate high-titer polioviruses found in potentially infectious materials. | ||
| E1885New | LY3522348 | LY3522348 is a highly selective oral dual inhibitor of the human ketohexokinase isoforms C and A, with IC50 values of 20nM for hKHK-C and 24nM for hKHK-A. It shows a significant pharmacodynamic effect in a mouse model of fructose metabolism. | ||
| E1889New | PCO371 | PCO371 is a nonpeptidyl, orally active agonist of Parathyroid hormone type 1 receptor (PTHR1). It stimulates cAMP production in COS-7 cells with an EC50 of 2.4 μmol/L. It also acts as an osteoporosis drug and significantly enhances bone mineral density (BMD) and bone strength in the lumbar vertebrae of osteopenic ovariectomized (OVX) rats. It also restores normal serum calcium levels without increasing urinary calcium in hypocalcemic thyroparathyroidectomized (TPTX) rats. | ||
| E5841New | Acetyl phosphate(lithium potassium) | Acetyl phosphate(lithium potassium) is an endogenous metabolite, bypasses the LytS membrane potential sensor by phosphorylating LytR twice as fast, influencing lrgAB operon regulation in glucose-rich conditions without membrane potential disruption. Lithium potassium acetyl phosphate is studied for its electrochemical properties and role in phosphorus chemistry, with potential applications in lithium-ion battery technology and catalytic processes. | ||
| E1995New | AZD-5462 | AZD-5462(Example 1) is a modulator of RXFP1, the cognate receptor for human relaxin, that belongs to the GPCR family 1c number. AZD-5462 exhibits anti-fibrotic and anti-inflammatory properties. | ||
| E1703New | SF2312 | SF2312 is a highly potent inhibitor of Enolase with IC50s of 37.9 nM and 42.5 nM for human recombinant ENO1 and ENO2, respectively, and also is a natural phosphonate antibiotic. SF2312 displays activity against bacteria under anaerobic conditions. | ||
| E1827New | ECC5004(AZD5004) | ECC5004(AZD5004, GLP-1 agonist (Eccogene)) is a small molecule GLP-1 receptor agonist (GLP-1RA) used to treat digestive system diseases and endocrine and metabolic diseases. ECC5004 has the potential to be used to treat obesity, type 2 diabetes and metabolic dysfunction-associated steatohepatitis (MASH) disease. | ||
| E5806New | Furimazine | Furimazine (PBI 3939) is a synthetic imidazopyrazinone compound that serves as a substrate for the NanoLuc luciferase (Nluc) enzyme. When combined with Nluc, Furimazine produces exceptionally bright bioluminescent signals in mammalian cells, significantly enhancing the sensitivity of bioluminescence imaging (BLI) applications. | ||
| S9911New | Chlorin e6 | Chlorin e6(Ce6, Phytochlorin) is a photosensitizer characterized by strong absorption peaks at 402 nm and 662 nm and intense fluorescence at 668 nm. It possesses antimicrobial and anticancer activities. It activates caspase-3 and induces apoptosis in cells, making it valuable for cancer research.Solutions are unstable and should be fresh-prepared. | ||
| E4634New | MIRA-1 | MIRA-1(NSC 19630), a maleimide compound, is a selective inhibitor of Werner syndrome WRN helicase activity with an IC50 of 20 µM while sparing ATPase and exonuclease activities. It reactivates mutant p53, inducing apoptosis in various human solid tumor cell lines with tetracycline-regulated mutant p53. | ||
| E1533New | Lipofermata | Lipofermata is an inhibitor of fatty acid transport protein 2 (FATP2) that demonstrates fatty acid transport inhibition with an IC50 of 4.84 μM in Caco-2 cells. It may offer therapeutic potential for diseases where lipotoxicity is a key factor. | ||
| E1403New | Fumarate hydratase-IN-1 | Fumarate hydratase-IN-1 is a small molecule cell-permeable inhibitor of fumarate hydratase. It induce alteration of TCA cycle metabolites, modulation of cytosolic processes, and substantial redox stress responses. | ||
| E4759New | MS41 | MS41 is a highly potent and selective PROTAC degrader of eleven-nineteen leukemia (ENL) that recruits the von Hippel–Lindau (VHL) E3 ubiquitin ligase, with DC50 values of 3.50 nM (MV4;11), 2.84 nM (SEMK2), 3.03 nM (Jurkat), and 26.58 nM (KASUMI1). It suppresses oncogenic gene expression, inhibits leukemia cell proliferation, and reduces MLL-r leukemia progression in a xenograft mouse model. | ||
| P1242New | Proteinase K | Proteinase K is a serine endoprotease, is used for isolating amyloid cores and is effective over a wide pH range (4–12), including in the presence of SDS or urea. It is commonly used as a preparative reagent for destruction of proteins, including DNAses and RNAses, in DNA and RNA preparations. | ||
| E4636New | W-7 hydrochloride | W-7 hydrochloride is a potent antagonist of calmodulin (CaM) that inhibits Dengue virus (DENV) translation and replication. It also competitively inhibits Trypsin-treated Ca2+/calmodulin-dependent phosphodiesterase (Ca2+-PDE). It exhibits anti-proliferative and anti-tumor effect. | ||
| E4728New | VVD-130037(BAY-3605349) | VVD-130037(BAY-3605349) is an orally available covalent small molecule activator of Kelch-like ECH associated protein 1 (KEAP1), which provide enhanced cellular degradation of nuclear factor-erythroid 2 p45-related factor 2 (NRF2) resulting in significant inhibition of tumor growth in advanced solid tumors. | ||
| E7278New | L-Methionine-DL-sulfoximine | L-Methionine-DL-sulfoximine (MSX, MSO) is an irreversible inhibitor of glutamine synthetase (GS) and pre-treatment delays the onset of behavioral and electrographic seizures in Pilo-treated rats. It also acts as a potent convulsant that metabolically and morphologogically primarily affects astroglia. | ||
| E1904New | SKF-34288 hydrochloride | SKF-34288 hydrochloride(3-Mercaptopicolinic acid hydrochloride, 3-MPA hydrochloride) is an orally active, specific inhibitor of phosphoenolpyruvate carboxykinase (PEPCK) with Ki values of 2-9 μM. SKF-34288 hydrochloride is a potent hypoglycemic agent by inhibiting glucose synthesis. SKF-34288 hydrochloride also inhibits cell proliferation, induces myogenic differentiation in vitro. | ||
| E4854New | Sodium picosulfate monohydrate | Sodium picosulfate monohydrate, is a polyphenolic stimulant laxative and prodrug form of desacetyl bisacodyl (DAB). It is used for treating idiopathic constipation and preparing the bowel before colonoscopy. | ||
| S5970New | Selenomethionine | Selenomethionine (Seleno-DL-methionine, DL-Selenomethionine) is a naturally occurring amino acid containing selenium. Selenomethionine (SeMet) can substitute for methionine (Met) during protein synthesis in a non-specific manner. Due to the significant differences in their redox properties, the incorporation of SeMet in place of Met may adversely impact protein function. | ||
| E1272New | SRI-37330 HCl | SRI-37330 HCl(EX-A5854), an anti-diabetic drug, is an orally bioavailable inhibitor of thioredoxin-interacting protein (TXNIP), with an IC50 of 0.64 μM for TXNIP expression in INS-1 cells. Its treatment inhibits glucagon secretion and function, decreases hepatic glucose production, and reverses hepatic steatosis. | ||
| E1758New | Bersacapavir | Bersacapavir(JNJ-6379, JNJ-56136379) is a potent capsid assembly modulator (CAM) that accelerates capsid assembly and induces the formation of morphologically intact viral capsids devoid of genomic material. It inhibits HBV replication with an EC50 of 54 nM in HepG2.117 cells. | ||
| A2169New | Anti-mouse MHC Class II (I-A/I-E)-InVivo | |||
| E1913New | MZ-101 | MZ-101 (GYS1-IN-2) is a potent small molecule inhibitor of Glycogen synthase 1(GYS1) with an IC50 value of 0.041 µM. By depleting muscle glycogen, MZ-101 treatment normalizes glycogen levels and corrects transcriptional and metabolic abnormalities in Pompe mice. | ||
| A2170New | Anti-mouse CSF1-InVivo | |||
| E4275New | β-Aminopropionitrile | β-Aminopropionitrile (BAPN) is an orally active, specific, and irreversible inhibitor of lysyl oxidase (LOX). It targets the active site of LOX or LOXL isoenzymes. | ||
| E4734New | MeAIB | MeAIB (α-(Methylamino)isobutyric acid) is a specific substrate for amino acid transport system A, especially System A (ATA1). It also inhibits SNAT2, which reduces intracellular levels of essential amino acids and impairs cell proliferation in porcine enterocytes by disrupting the mTOR signalling pathway. | ||
| E4852New | Tafamidis meglumine | Tafamidis meglumine (Vyndaqel, Fx-1006A) stabilizes the tetrameric structure of transthyretin (TTR) by binding to thyroxine-binding sites. Tafamidis meglumine treats transthyretin familial amyloid polyneuropathies (TTR-FAP), a condition characterized by neurological damage from TTR amyloidosis, by preventing the misfolding and aggregation of transthyretin (TTR) into amyloid fibrils. | ||
| E4922New | Allopurinol riboside | Allopurinol riboside, a metabolite of allopurinol, competitively inhibits the action of purine nucleoside phosphorylase on inosine in vitro with a Ki value of 277 μM. It displays potent activities against parasites. | ||
| E1616New | AZD8797( KAND567) | AZD8797 (KAND567) is an allosteric, non-competitive, and orally active antagonist of the human receptor CX3CR1. It antagonizes CX3CR1 with a Ki value of 3.9 nM, respectively. It effects G-protein signaling and β-arrestin recruitment. | ||
| E7078New | N2,N2-Dimethylguanosine | N²,N²-Dimethylguanosine (m 2 2 G) is a key post-transcriptional modification found in tRNAs, where two methyl groups are added to the N² position of guanosine. This modification is essential for improving tRNA structural stability and functionality, particularly at positions like G26, which are critical for ensuring the correct conformation for efficient translation. Enzymes such as Trm1 (in yeast) and TRMT1 (in humans) catalyze the formation of m²₂G using S-adenosylmethionine (SAM) as a methyl donor. This modification supports cellular functions, modulates stress responses, and ensures proper translation efficiency. | ||
| E5772New | DC_AC50 | DC_AC50 is an inhibitor of the copper-trafficking proteins Atox1 (kd ∼6.8 µM) and full-length CCS (kd ∼8.2 µM) that significantly suppressing cell proliferation in various human cancer cell lines. | ||
| E6033New | Cilastatin sodium | Cilastatin sodium (MK0791 sodium) is a reversible, competitive inhibitor of renal dehydropeptidase I (also known as membrane dipeptidase, MDP), with an IC50 of 0.1 µM. It is primarily used in combination with imipenem to enhance the antibiotic's effectiveness against a broad spectrum of bacterial infections by preventing its degradation in the kidneys. | ||
| E4808New | Propionyl-L-carnitine hydrochloride | Propionyl-L-carnitine hydrochloride(Levocarnitine propionate hydrochloride) supports mitochondrial metabolism, offers cardiovascular benefits, acts as a free radical scavenger, and is used in treating colonic inflammatory bowel disease. | ||
| E0428New | IMP-1088 | IMP-1088 is a potent dual inhibitor of human N-myristoyltransferases NMT1 and NMT2, with an IC50 of <1 nM for HsNMT1 and HsNMT2 and a Kd of <210 pM for HsNMT1. It effectively inhibits the production of infectious rhinovirus virions by blocking the N-myristoylation of the rhinovirus VP0 protein. | ||
| E7081New | Purpurin 18 | Purpurin-18 is a chlorophyll-derived dihydroporphyrin, serves as a key precursor for photosensitizers like purpurinimides, which absorb light in the 700–850 nm range. It demonstrate potent photodynamic anti-tumor activity and generates ROS, disrupting mitochondrial membrane potential and inducing apoptosis against triple-negative breast cancer both in vitro and in vivo. | ||
| E1951New | X5050 | X5050 is a benzoimidazole-5-carboxamide derivative and a potent inhibitor of repressor element-1 silencing transcription factor (REST) with an EC50 of 2.1 μM. It can be used in research of Huntington's disease and other neurodegenerative disorders characterized by altered BDNF levels. | ||
| E1317New | LY 345899 | LY345899 is a Folate analog and a potent inbhibitor of methylene tetrahydrofolate dehydrogenase1 (MTHFD1; DC301) and methylene tetrahydrofolate dehydrogenase2 (MTHFD2) with IC50 values of 96 nM and 663 nM, respectively. It significantly suppresses tumor growth and reduces tumor weight in CRC patient-derived xenograft models. | ||
| S8145New | Plicamycin | Plicamycin (Mithramycin A) a selective inhibitor of Sp1, is a natural polycyclic aromatic polyketide isolated from Streptomyces strains. It binds to GC-rich DNA sequences, displacing Sp1 transcription factor from oncogene promoters, inhibiting their expression, with anti-tumor and neuroprotective effects. | ||
| E4610New | SMIP34 | SMIP34 is a small molecule inhibitor of proline, glutamic acid, and leucine-rich protein 1 (PELP1). It is effective in reducing cell viability, reducing invasion, and inducing apoptosis in Triple-negative breast cancer (TNBC) models. | ||
| E7096New | Insulin(cattle) | Insulin(cattle) is a two-chain polypeptide hormone produced by pancreatic β cells and commonly used as a growth supplement in cell culture. Its native structure is crucial for receptor interaction, regulating glucose homeostasis, while its stable hexameric form or analogs are used for storage and injection. | ||
| S0792New | Varoglutamstat | Varoglutamstat (PQ912) is an inhibitor of glutaminyl cyclase (QC), inhibiting human glutaminyl cyclase (hQC) activity with a Ki of 25 nM (pH 8.0). It reduces pyroglutamyl-Aβ (pE-Aβ) levels and can be used in Alzheimer's disease research. | ||
| S6932New | Senaparib | Senaparib(IMP4297, JS109) is a potent, selective and orally active PARP1/2 inhibitor with strong antitumor activity in preclinical studies. | ||
| S0123New | Roflumilast N-oxide | Roflumilast N-oxide is an inhibitor of PDE type 4. | ||
| E0623New | HBC620 | HBC620 is an analogue of HBC which is a GFP fluorophore-like synthetic dye that is nonfluorescent in solution, but strongly fluoresces upon forming tight complex with Pepper RNA aptamer. HBC-Pepper complex can be used to visualize RNA dynamics in live cells. | ||
| S7407New | NFAT Inhibitor | NFAT Inhibitor (VIVIT peptide) is a selective inhibitor of nuclear factor of activated Tcells (NFAT) activation that effectively blocks calcineurin-mediated dephosphorylation of NFAT in cell extracts. It also serves as a valuable tool for the direct identification of NFAT target genes across various cell types. | ||
| E1795New | Triparanol(MER-29) | Triparanol (MER-29) is an inhibitor of 24-dehydrocholesterol reductase (DHCR24), an enzyme involved in cholesterol biosynthesis. It exhibits antitumor properties, such as decreasing proliferation and inducing apoptosis in various cancer cell lines, while also reducing Hedgehog pathway signaling in these cells. | ||
| E4778New | BODIPY 493/503 | BODIPY 493/503 (Pyrromethene 546, BDP 493/503 lipid stain) is a fluorescent neutral lipophilic dye. It is used to facilitate quantification of neutral lipid content, a lipid droplet–associated protein by flow cytometry and observation of lipid droplets(LDs) by microscopy. | ||
| E4657New | PFI-6 | PFI-6 is a selective MLLT1/3 probe that targets the YEATS domain of MLLT1 (ENL/YEATS1) and MLLT3 (AF9/YEATS3) with IC50 values of 140 nM and 160 nM for MLLT1 and MLLT3, respectively. PFI-6 demonstrates increased affinity and selectivity for MLLT1/3 than other human YEATS domain proteins (YEATS2/4). | ||
| E1628New | BMS-911172 | BMS-911172 is a brain penetrant, selective inhibitor of adaptor protein 2-associated kinase 1 (AAK1) with an IC50 value of 12 nM. BMS-911172 inhibits μ2 phosphorylation and has potential as a therapeutic agent in neuropathic pain research. | ||
| E6015New | Heparin (Lithium salt) | Heparin Lithium salt is an anticoagulant that binds reversibly to antithrombin III (ATIII). Heparin Lithium salt is used as an anticoagulant for laboratory studies and in direct membrane-feeding assays. | ||
| P1243New | Fetuin, Fetal Bovine Serum | Fetuin, Fetal Bovine Serum, a prevalent protein found in fetal bovine plasma, is the bovine equivalent of human α2HS glycoprotein (α2HS), commonly used as a supplement in various serum-free media. It inhibits trypsin activity and enhances cellular attachment, growth, and differentiation in culture systems. | ||
| E4637New | PK 11195 | PK 11195 (RP 52028) is a translocator protein (TSPO) ligand, a potent and selective antagonist of peripheral benzodiazepine receptorwith high affinity Ki of 3.1 nM in cerebellum and 4.1 nM in spinal cord. It is also an antagonist of human constitutive androstane receptor (hCAR), and human pregnane X receptor (PXR). It displaces [3H] RO5-4864 from its binding sites across organs and also targets Leishmania in chemotherapy. | ||
| E6006New | Deferasirox (Fe3+ chelate) | Deferasirox (Fe3+ chelate) (Exjade) is an oral tridentate iron chelator used for reducing transfusional chronic iron overload. It exhibits efficacy in iron-overloaded patients with anemias, thalassemia, sickle cell disease and myelodysplastic syndromes. It is also an orally effective antitumor agent against solid tumors. | ||
| E4732New | FDW028 | FDW028 is a highly potent and selective inhibitor of FUT8. FDW028 demonstrates strong anti-tumor effects by promoting defucosylation and inducing lysosomal degradation of B7-H3 via the chaperone-mediated autophagy (CMA) pathway. Additionally, FDW028 suppresses the AKT/mTOR signaling pathway. FDW028 exhibits potent anti-Metastatic colorectal cancer (mCRC) activities. | ||
| E1896New | BMS-502 | BMS-502 is a potent dual inhibitor of diacylglycerol kinase (DGK) α and ζ with IC50 values of 4.6 nM and 2.1 nM, respectively. BMS-502 also exhibits an EC50 value of 340 nM in the mouse cytotoxic T cell IFN-γ assay (mCTC). BMS-502 can be used in tumor immunity-related research. | ||
| E4661New | dWIZ-2 | dWIZ-2, is a molecular glue degrader of the WIZtranscription factor degrading WIZ with a DC50 of 32 nM. It also robustly induces fetal hemoglobin (HbF) in erythroblasts with an EC50 of 202 nM. | ||
| E4960New | L-Lysine hydrate | L-Lysine hydrate is a first-limiting, essential amino acid with important roles in connective tissues and carnitine synthesis, energy production, growth in children, and maintenance of immune functions. It also ameliorates vascular calcification by modifying several key pathways and attenuates pancreatic tissue injury induced by L-arginine by inhibiting the release of the inflammatory cytokine IL-6. | ||
| E1948New | ZT-1a | ZT-1a is a potent and selective, non-ATP-competitive inhibitor of STE20/SPS1-related proline-alanine-rich kinase (SPAK) with an IC50 of 44.3 μM. It can exhibit therapeutic potential for brain disorders linked to impaired ionic homeostasis in research. | ||
| E7144New | PAR-4 Agonist Peptide, amide | PAR-4 Agonist Peptide, amide is a agonist of proteinase-activated receptor-4 (PAR-4) that provides antinociceptive effects in stress- and inflammation-induced hyperalgesia. It reduces visceral pain by activating PAR-4 receptors on colonic nerve terminals. | ||
| E4889New | Glafenine | Glafenine (Glafenin) is a non-steroidal anti-inflammatory drug (NSAID) and is a non-narcotic analgesic agent that not only acts as a proteostasis modulator but is also one of the most potent NSAID correctors of F508del-CFTR. It exhibits COX-2 inhibition in the arachidonic acid pathway and rescues class 2 CFTR mutants. | ||
| E4716New | QS11 | QS11 acts as an inhibitor of ARFGAP1 (ADP-ribosylation factor GTPase-activating protein 1), with an EC50 of 1.5 μM. QS11 regulates Wnt/β-catenin signaling by interacting with ARF GTPase-activating protein 1 (ARFGAP1) and influences protein trafficking. Additionally, QS11 suppresses the migration of breast cancer cells that overexpress ARFGAP1. | ||
| E4997New | BAY 2927088（Sevabertinib） | BAY 2927088（Sevabertinib) is the first non-covalent, potent, oral, selective, and reversible inhibitor of tyrosine kinase that potently inhibits mutant HER2 and mutant EGFR in preclinical models. It targets Exon 20 insertions in non-small-cell lung carcinoma (NSCLC) patients. | ||
| E5777New | Tris(benzyltriazolylmethyl)amine | Tris(benzyltriazolylmethyl)amine (TBTA) is a ligand used as a biochemical tool for labeling proteins and enzymes. It dramatically enhances the Copper(II) acetate (Cu(OAc)2)-accelerated azide-alkyne cycloaddition (AAC) reactions involving nonchelating azides. | ||
| E1798New | HOIPIN-8 | HOIPIN-8, is a potent inhibitor of linear ubiquitin chain assembly complex (LUBAC) and NF-κB signaling with an IC50 value of 11 nM. It serves as a powerful tool for investigating the physiological and cellular functions of LUBAC. | ||
| E1637New | ALKBH5 inhibitor 1 (compound 3) | ALKBH5 inhibitor 1 (compound 3) is an inhibitor of the RNA m6A Demethylase ALKBH5, with an IC50 value of 0.84 μM. It also exhibits potent antiproliferative activity. | ||
| E4782New | 17-OH PREG (17a-Hydroxypregnenolone) | 17-OH PREG (17a-Hydroxypregnenolone) is a pregnenolone metabolite and DHEA precursor. It is formed through CYP17A1 hydroxylase and 17,20-lyase activities. It is the most relevant steroid for the study of elevated plasma levels linked to type II 3β-hydroxysteroid dehydrogenase deficiency. | ||
| E7386New | Fructose | Fructose (beta-D-Fructopyranose) is a highly soluble, sweet monosaccharide used as a sweetener in food and beverages, providing moisture retention and enhancing flavor. It functions as a humectant, lowers freezing points, and improves texture in various products. | ||
| E1264New | VIT-2763 | VIT-2763 is an oral small-molecule inhibitor of ferroportin. It displaces TMR-hepcidin from ferroportin with an IC50 of 24 nM. It also ameliorates anemia, enhances erythropoiesis, and reduces organ iron loading in the Hbbth3/+ β-thalassemia intermedia disease model. | ||
| E1910New | TASIN-30 | TASIN-30 is a selective inhibitor of Emopamil binding protein (EBP) with EC50 values of 0.097 μM for EBP competition, respectively. TASIN-30 displays selectivity for EBP over DHCR24. | ||
| E1800New | Oxythiamine chloride hydrochloride | Oxythiamine chloride hydrochloride(Hydroxythiamine chloride hydrochloride) is a salt form of Oxythiamine. It is an inhibitor of transketolase, the enzyme that controls the nonoxidative branch of the pentose phosphate pathway. It also suppresses tumor cell proliferation and promotes apoptosis. | ||
| E4593New | Benzo-15-crown-5 ether | Benzo-15-crown-5-ether (B15C5) is employed as a ligand in metal-catalyzed reactions to improve reactivity and selectivity by coordinating with metal cations. Additionally, it serves as a chelating agent for sodium and potassium ions. | ||
| E4594New | Lithium iodide hydrate | Lithium iodide hydrate is a reagent and the water-crystallized form of lithium iodide. It is commonly used as an electrolyte additive in dye-sensitized solar cells and Li-S batteries, enhancing their cycle life. | ||
| E1536New | (R)-HTS-3 (GLXC-25878) | (R)-HTS-3 (GLXC-25878) is a potent, selective, and cell-active inhibitor of lysophosphatidylcholine acyltransferase 3 (LPCAT3) with an IC50 of 0.09 µM, an enzyme critical for synthesizing C20:4-containing phospholipids. It reduces arachidonic acid-d8 incorporation into phospholipids and mitigates RSL3-induced ferroptosis in HT-1080 and 786-O cancer cells. | ||
| E8033New | DO-264 | DO-264 is a potent, selective, and in vivo-active inhibitor of ABHD12, a lysophospholipid hydrolase enzyme, with an IC50 of 11 nM. It dose-dependently increases levels of lysophosphatidylserine (lyso-PS) and 20:4 phosphatidylserine (20:4 PS) in brain tissue. It also enhances immunological responses in lymphocytic choriomeningitis virus (LCMV) infection. | ||
| E1907New | HADA hydrochloride | HADA hydrochloride (HCC-Amino-D-alanine hydrochloride) is a blue fluorescent D-amino acid (FDAA) that labels peptidoglycans in live bacteria without affecting growth and also displays mitochondrial outer membrane permeability. | ||
| E4941New | Diflorasone diacetate | Diflorasone diacetate(Florone), is a steroid anti-inflammatory drug, an inhibitor of TARC (thymus and activation regulated chemokine; CCL17) in the dinitrochlorobenzene (DNCB) model. It can be used in the treatment of allergic and inflammatory skin diseases such as atopic dermatitis and allergic contact dermatitis. | ||
| E4932New | Amikacin | Amikacin(BAY 41-6551, Lukadin) is a semisynthetic aminoglycoside, derived from kanamycin-A, that acts as an inhibitor of the Z ring formation, leading to the inhibition of cell division. It is used to treat serious infections caused by aerobic Gram-negative bacteria, mycobacteria, Nocardia, and life-threatening infections in neonates. | ||
| E4666New | O-Propargyl-Puromycin | O-Propargyl-Puromycin (OP-puro) is an alkyne puroanalog, a potent inhibitor of protein synthesis . It is used to label nascent proteins in whole animals, allowing the visualization of protein synthesis patterns in large explants from tissues and organs. | ||
| E4958New | cis-Bac430 | Cis-Bac430 plays a role in mediating the movement of anti-tumor CD8+cells from the periphery to the tumor site,thus enhancing the anti-tumor effect of an immune checkpoint inhibitor. | ||
| E7195New | N-Acetyl-D-cysteine | N-Acetyl-D-cysteine is a derivative of cysteine with antioxidant properties. It shares some properties with N-acetyl-L-cysteine, such as ROS scavenging due to its thiol group, but it cannot participate in glutathione biosynthesis. | ||
| A4061New | Emicizumab (Anti-Factor IX & Factor X) | Emicizumab is a recombinant, humanized, bispecific antibody that binds Factor IXa and Factor X to mimic Factor VIII function. It is used to treat hemophilia A. M.W 146.82 kDa | ||
| E4785New | BAP1-IN-1 | BAP1-IN-1 is a small-molecule inhibitor of BRCA1 associated protein 1 (BAP1) catalytic activity in vitro with an IC50 of 0.1-1 μM. It exhibits a potential therapeutic target for leukemia. | ||
| E7200New | Ceramides Mixture | Ceramides Mixture are endogenous long chain, bioactive lipids forming the hydrophobic backbone of complex sphingolipids and are major constituents of the stratum corneum, contributing to the skin's permeability barrier. They regulate key biological processes such as growth inhibition, cell cycle arrest, telomerase activity modulation, proliferation, apoptosis, and senescence. | ||
| E4816New | Choline hydroxide, 42.5 wt.% in water | Choline hydroxide, 42.5 wt.% in water, is a strong organic base used as a metal-free, nontoxic, and water-soluble catalyst. It facilitates the synthesis of 1,8-naphthyridine derivatives while avoiding the use of hazardous or carcinogenic organic solvents. | ||
| E5773New | Gypenoside L | Gypenoside L, is a saponin from Gynostemma pentaphyllum, increases SA-β-galactosidase activity, enhances senescence-associated cytokine production, inhibits proliferation and LPS-induced nitric oxide (NO) production, induces S-phase arrest, and activates p21, p27, p38, ERK MAPK, and NF-κB pathways to promote senescence. | ||
| E4902New | Dantrolene | Dantrolene is an antagonist of ryanodine receptor (RYR) and a postsynaptic skeletal muscle relaxant that reduces calcium release from the sarcoplasmic reticulum (SR), leading to a dose-dependent decrease in myoplasmic free calcium levels. It is used to treat and control the accelerated hypermetabolism of skeletal muscle that leads to a malignant hyperthermia crisis. | ||
| P1245New | Bovine Serum Albumin | Bovine serum albumin (BSA, Albumin bovine serum) is an efficient passivating agent that inhibits nonspecific protein binding in assays such as ELISA. It is used to coat hydrophobic substrates, enhancing anti-fouling properties and reducing immune system interactions. | ||
| E1889New | PCO371 | PCO371 is a nonpeptidyl, orally active agonist of Parathyroid hormone type 1 receptor (PTHR1). It stimulates cAMP production in COS-7 cells with an EC50 of 2.4 μmol/L. It also acts as an osteoporosis drug and significantly enhances bone mineral density (BMD) and bone strength in the lumbar vertebrae of osteopenic ovariectomized (OVX) rats. It also restores normal serum calcium levels without increasing urinary calcium in hypocalcemic thyroparathyroidectomized (TPTX) rats. | ||
| E7144New | PAR-4 Agonist Peptide, amide | PAR-4 Agonist Peptide, amide is a agonist of proteinase-activated receptor-4 (PAR-4) that provides antinociceptive effects in stress- and inflammation-induced hyperalgesia. It reduces visceral pain by activating PAR-4 receptors on colonic nerve terminals. |
Others阻害剤の選択性比較
Tags: Others inhibitor|Others agonist|Others activator|Others inducer|Others antagonist|Others signaling pathway|Others assay kit
納期 国内在庫品：受注日の翌日（15時までの受注分） ＊北海道、九州、沖縄への配送は受注日より２日以上 を要する場合あり 海外在庫品：受注後１〜２週間