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Lycopene
別名：ψ,ψ-Carotene
Lycopene (ψ,ψ-Carotene) is a linear, unsaturated hydrocarbon carotenoid, the major red pigment in fruits such as tomatoes, pink grapefruit, apricots, red oranges, watermelon, rosehips, and guava. It is a natural antioxidant.
CAS No. 502-65-8
文献中Selleckの製品使用例（1）
Lycopene関連製品
生物活性
| 製品説明 | Lycopene (ψ,ψ-Carotene) is a linear, unsaturated hydrocarbon carotenoid, the major red pigment in fruits such as tomatoes, pink grapefruit, apricots, red oranges, watermelon, rosehips, and guava. It is a natural antioxidant. |
|---|
| In Vitro | ||||
| In vitro | Lycopene is found in nature in the all-trans form; however, thermal processing, as well as intestinal digestion, of raw tomato products facilitates its cis-isomerization[3]. Lycopene is recognized to be the most efficient singlet oxygen quencher among biological carotenoids. Antioxidant functions are associated with lowering DNA damage, malignant transformation, and reducing biological oxidative damage of proteins, lipids, and other cell components in vitro. Lycopene has also been found to increase gap-junctional communication between cells and to induce the synthesis of connexin-43[1]. It negatively affects cancer cells or development of cancer by modulating cell cycle progression and cell proliferation and has an inhibitory effect on DNA synthesis, initiating up-regulation of gap-junction proteins and a reduction of local androgen signaling, impact IGIF-1 signaling, antioxidant activity and induction of apoptotic cell death[2]. | |||
|---|---|---|---|---|
| 細胞実験 | 細胞株 | HT-29, T84 and MCF-7 cells | ||
| 濃度 | 1-5 μM | |||
| 反応時間 | 48 and 96 h | |||
| 実験の流れ | Human cell lines are treated with lycopene (1-5 μM) for 48 and 96 h. Cell viability is monitored using the method of MTT. The cell cycle is analyzed by flow cytometry, and apoptotic cells are identified by terminal deoxynucleotidyl transferase-mediated dUTP nick labeling (TUNEL) and by DAPI. |
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| In Vivo | ||
| In Vivo | Lycopene has been reported to increase the survival rate of mice exposed to X-ray radiation. Lycopene has been reported to increase the survival rate of mice exposed to X-ray radiation. It is found that the consumption of lycopene in fruits and vegetables may reduce the likelihood of developing heart disease. Lycopene prevents oxidation of low-density lipoprotein (LDL) cholesterol and reduces the risk of developing atherosclerosis and coronary heart disease. Lycopene is as effective as β-carotene in inhibiting the growth of the glioma cells in the model of glioma cells transplanted in rats[1]. Lycopene acts as an antioxidant agent both through a decrease in intracellular reactive species production in vitro and in vivo through the neutralization of reactive species, the restoration of the GSH/GSSG ratio, decrease in oxidatively generated damage and decrease in proinflammatory cytokines through decreased cell influx as well as direct suppression of cytokine production[3]. | |
|---|---|---|
| 動物実験 | 動物モデル | Male C57BL/6 mice |
| 投与量 | 25 or 50 mg/kg/day | |
| 投与経路 | by orogastric gavage | |
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT04446624 | Completed | Breast Cancer|Depression Anxiety|Oxidative Stress |
Università degli Studi del Piemonte Orientale Amedeo Avogadro |
February 1 2018 | Not Applicable |
| NCT03608254 | Completed | Vascular Health of Postmenopausal Women |
University of Alabama Tuscaloosa |
November 5 2015 | -- |
化学情報
| 分子量 | 536.87 | 化学式 | C40H56 |
| CAS No. | 502-65-8 | SDF | -- |
| Smiles | CC(=CCCC(=CC=CC(=CC=CC(=CC=CC=C(C)C=CC=C(C)C=CC=C(C)CCC=C(C)C)C)C)C)C | ||
| 保管 | 3 years -20°C(in the dark) powder | ||
|
in vivo Add solvents to the product individually and in order. |
投与溶液組成計算機 | ||||
実験計算
投与溶液組成計算機(クリア溶液)
ステップ１：実験データを入力してください。（実験操作によるロスを考慮し、動物数を1匹分多くして計算・調製することを推奨します）
mg/kg
g
μL
匹
ステップ２：投与溶媒の組成を入力してください。（ロット毎に適した溶解組成が異なる場合があります。詳細については弊社までお問い合わせください）
% DMSO
%
% Tween 80
% ddH2O
%DMSO
%
計算結果：
投与溶媒濃度： mg/ml;
DMSOストック溶液調製方法： mg 試薬を μL DMSOに溶解する（濃度 mg/mL, 注：濃度が当該ロットのDMSO溶解度を超える場合はご連絡ください。 )
投与溶媒調製方法：Take μL DMSOストック溶液に μL PEG300，を加え、完全溶解後μL Tween 80，を加えて完全溶解させた後 μL ddH2O，を加え完全に溶解させます。
投与溶媒調製方法：μL DMSOストック溶液に μL Corn oil，を加え、完全溶解。
注意：１.ストック溶液に沈殿、混濁などがないことをご確認ください；
２.順番通りに溶剤を加えてください。次のステップに進む前に溶液に沈殿、混濁などがないことを確認してから加えてください。ボルテックス、ソニケーション、水浴加熱など物理的な方法で溶解を早めることは可能です。
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Tags: Lycopeneを買う | Lycopene ic50 | Lycopene供給者 | Lycopeneを購入する | Lycopene費用 | Lycopene生産者 | オーダーLycopene | Lycopene化学構造 | Lycopene分子量 | Lycopene代理店
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