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Cholic acid
Cholic acid is a naturally occurring bile acid that is insoluble in water and is used to treat patients with genetic deficiencies in the synthesis of bile acids.
CAS No. 81-25-4
文献中Selleckの製品使用例（2）
製品安全説明書
現在のバッチを見る：
S374201
DMSO]
81 mg/mL]
false]
Ethanol]
28 mg/mL]
false]
Water]
Insoluble]
false
純度：
98.58%
98.58
Cholic acid関連製品
生物活性
| 製品説明 | Cholic acid is a naturally occurring bile acid that is insoluble in water and is used to treat patients with genetic deficiencies in the synthesis of bile acids. |
|---|
| In Vitro | ||||
| In vitro | Fosfomycin is known to inhibit MurA by covalently binding to a highly conserved cysteine in the active site of the enzyme. Fosfomycin is a PEP mimetic that acts by alkylating the highly conserved Cys115 (Escherichia coli numbering) of MurA[1]. Fosfomycin exerts immunomodulatory effects by altering lymphocyte, monocyte and neutrophil function. It affects the acute inflammatory cytokine response in vitro and in vivo. It suppresses production of tumor necrosis factor alpha (TNF-α), interleukin-1β (IL-1β), and IL-1α and increases production of IL-10. Fosfomycin suppresses IL-2 production from T cells, the production of leukotriene B4 (LTB4) from neutrophils, and the expression of IL-8 mRNA by LTB4 from monocytes. Fosfomycin also exhibits an immunomodulatory effect on B-cell activation. Fosfomycin enhances neutrophil phagocytic killing of invading pathogens, even in patients on chronic hemodialysis and renal transplantation. Fosfomycin resulted in enhanced bactericidal ability of neutrophils compared to other antimicrobials. Fosfomycin has the ability to penetrate into biofilms. fosfomycin is considerably active against both Gram-negative and Gram-positive pathogens[2]. | |||
|---|---|---|---|---|
| In Vivo | ||
| In Vivo | The oral bioavailability of fosfomycin trometamol ranges between 34 and 58%. Absorption occurs in the small intestine, and evidence suggests that coadministration of fosfomycin trometamol with food may reduce absorption of the drug.The mean serum elimination half-life (t1/2) of fosfomycin trometamol is estimated at 5.7 h. Fosfomycin is excreted nonmetabolized in the urine, through glomerular filtration. Depending on age, fasting, and renal function, 11 to 60% of the drug can be found in the urine within 24 h from administration. Specifically, older age, administration with a meal, and deteriorating renal function result in slower elimination through the kidneys. Fosfomycin crosses the blood-brain barrier, and meningeal inflammation increases its concentration in the CSF. Fosfomycin also penetrates in both cortical and cancellous bone, and penetration correlates with plasma levels and the presence of inflammation[2]. | |
|---|---|---|
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT02654496 | Completed | Obesity |
North Dakota State University |
January 2016 | -- |
| NCT01865812 | Completed | Primary Biliary Cirrhosis |
Intercept Pharmaceuticals |
December 3 2013 | Phase 2 |
| NCT00596427 | Completed | Diabetes |
Carine Beysen|KineMed |
November 2007 | Not Applicable |
| NCT01589523 | Completed | Bile Acid Synthesis Defect|Inborn Error of Bile Acid Metabolism|Inborn Error of Bile Acid Conjugation |
Children''s Hospital Medical Center Cincinnati |
February 2006 | Phase 3 |
化学情報
| 分子量 | 408.57 | 化学式 | C24H40O5 |
| CAS No. | 81-25-4 | SDF | Download Cholic acid SDFをダウンロードする |
| Smiles | CC(CCC(=O)O)C1CCC2C1(C(CC3C2C(CC4C3(CCC(C4)O)C)O)O)C | ||
| 保管 | |||
|
In vitro |
DMSO : 81 mg/mL ( (198.25 mM)； 吸湿したDMSOは溶解度を減少させます。新しいDMSOをご使用ください。) Ethanol : 28 mg/mL Water : Insoluble |
モル濃度計算器 |
|
in vivo Add solvents to the product individually and in order. |
投与溶液組成計算機 | ||||
実験計算
投与溶液組成計算機(クリア溶液)
ステップ１：実験データを入力してください。（実験操作によるロスを考慮し、動物数を1匹分多くして計算・調製することを推奨します）
mg/kg
g
μL
匹
ステップ２：投与溶媒の組成を入力してください。（ロット毎に適した溶解組成が異なる場合があります。詳細については弊社までお問い合わせください）
% DMSO
%
% Tween 80
% ddH2O
%DMSO
%
計算結果：
投与溶媒濃度： mg/ml;
DMSOストック溶液調製方法： mg 試薬を μL DMSOに溶解する（濃度 mg/mL, 注：濃度が当該ロットのDMSO溶解度を超える場合はご連絡ください。 )
投与溶媒調製方法：Take μL DMSOストック溶液に μL PEG300，を加え、完全溶解後μL Tween 80，を加えて完全溶解させた後 μL ddH2O，を加え完全に溶解させます。
投与溶媒調製方法：μL DMSOストック溶液に μL Corn oil，を加え、完全溶解。
注意：１.ストック溶液に沈殿、混濁などがないことをご確認ください；
２.順番通りに溶剤を加えてください。次のステップに進む前に溶液に沈殿、混濁などがないことを確認してから加えてください。ボルテックス、ソニケーション、水浴加熱など物理的な方法で溶解を早めることは可能です。
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