ホームページ Protein Tyrosine Kinase EGFR inhibitor - HER2 inhibitor - Autophagy activator Afatinib Dimaleate For research use only.

Afatinib Dimaleate

別名：BIBW2992 Dimaleate

Afatinib Dimaleate irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM, respectively; 100-fold more active against Gefitinib-resistant L858R-T790M EGFR mutant. Afatinib (BIBW2992) Dimaleate induces autophagy.

Afatinib Dimaleate化学構造

CAS No. 850140-73-7

サイズ 価格(税別) 在庫状況
10mM (1mL in DMSO) JPY 29500 国内在庫あり
JPY 22000 国内在庫あり
JPY 37000 国内在庫あり
JPY 55500 国内在庫あり
JPY 118500 国内在庫なし(納期7~10日)

代表番号: 045-509-1970|電子メール：[email protected]
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文献中Selleckの製品使用例（167）

製品安全説明書

現在のバッチを見る： 純度： 99.98%
99.98

Afatinib Dimaleate関連製品

シグナル伝達経路

EGFR Signaling Pathways

EGFRシグナル伝達経路

EGFR阻害剤の選択性比較

Cell Data

Cell Lines Assay Type Concentration Incubation Time 活性情報 PMID
NCI-H1975 Proliferation assay 72 h Antiproliferative activity against human NCI-H1975 cells expressing EGFR T790M mutant after 72 hrs by SRB assay, IC50=0.148 μM 24183742
A431 Proliferation assay 72 h Antiproliferative activity against human A431 cells after 72 hrs by SRB assay, IC50=0.023 nM 24183742
MDA-MB-231 Proliferation assay 72 h Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay, EC50=1 nM 20180906
NCI-H1975 Cytotoxicity assay 48 h Cytotoxicity against human NCI-H1975 cells after 48 hrs by MTT assay, IC50=0.392 μM 20150404
NIH/3T3 Cytotoxicity assay 48 h Cytotoxicity against mouse NIH/3T3 cells after 48 hrs by MTT assay, IC50=3.605 μM 20150404
A549 Cytotoxicity assay 72 h Cytotoxicity against human A549 cells after 72 hrs by MTT assay, IC50=0.05 μM 20180905
PC3 Cytotoxicity assay 72 h Cytotoxicity against human PC3 cells after 72 hrs by MTT assay, IC50=4.1 μM 20180905
HeLa Cytotoxicity assay 72 h Cytotoxicity against human HeLa cells after 72 hrs by MTT assay, IC50=6.81 μM 20180905
MCF7 Cytotoxicity assay 72 h Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay, IC50=5.83 μM 20180905
NSCLC Cytotoxicity assay 72 h Cytotoxicity against human NSCLC cells, IC50=0.5 nM 20180905
HCC827 cell Proliferation assay Antiproliferative activity against human HCC827 cells after 96 hrs by MTS assay, IC50=8 nM 20550212
NCI-H1563 Growth inhibition assay Inhibition of human NCI-H1563 cell growth in a cell viability assay. IC50=9.76031 μM SANGER
NCI-H1573 Growth inhibition assay Inhibition of human NCI-H1573 cell growth in a cell viability assay. IC50=0.7363 μM SANGER
NCI-H1581 Growth inhibition assay Inhibition of human NCI-H1581 cell growth in a cell viability assay. IC50=29.3145 μM SANGER
NCI-H1648 Growth inhibition assay Inhibition of human NCI-H1648 cell growth in a cell viability assay. IC50=0.44182 μM SANGER
NCI-H1793 Growth inhibition assay Inhibition of human NCI-H1793 cell growth in a cell viability assay. IC50=14.2087 μM SANGER
NCI-H1838 Growth inhibition assay Inhibition of human NCI-H1838 cell growth in a cell viability assay. IC50=0.60299 μM SANGER
NCI-H1770 Growth inhibition assay Inhibition of human NCI-H1770 cell growth in a cell viability assay. IC50=0.1028 μM SANGER
NCI-H1651 Growth inhibition assay Inhibition of human NCI-H1651 cell growth in a cell viability assay. IC50=25.597 μM SANGER
NCI-H1975 Growth inhibition assay Inhibition of human NCI-H1975 cell growth in a cell viability assay. IC50=0.61728 μM SANGER
NCI-H1666 Growth inhibition assay Inhibition of human NCI-H1666 cell growth in a cell viability assay. IC50=1.80948 μM SANGER
NCI-H2009 Growth inhibition assay Inhibition of human NCI-H2009 cell growth in a cell viability assay. IC50=3.61216 μM SANGER
NCI-H2126 Growth inhibition assay Inhibition of human NCI-H2126 cell growth in a cell viability assay. IC50=0.51926 μM SANGER
NCI-H1693 Growth inhibition assay Inhibition of human NCI-H1693 cell growth in a cell viability assay. IC50=3.84181 μM SANGER
NCI-H2087 Growth inhibition assay Inhibition of human NCI-H2087 cell growth in a cell viability assay. IC50=49.9682 μM SANGER
NCI-H2029 Growth inhibition assay Inhibition of human NCI-H2029 cell growth in a cell viability assay. IC50=43.5581 μM SANGER
NCI-H2170 Growth inhibition assay Inhibition of human NCI-H2170 cell growth in a cell viability assay. IC50=0.03728 μM SANGER
NCI-H226 Growth inhibition assay Inhibition of human NCI-H226 cell growth in a cell viability assay. IC50=49.7785 μM SANGER
NCI-H2030 Growth inhibition assay Inhibition of human NCI-H2030 cell growth in a cell viability assay. IC50=14.6448 μM SANGER
NCI-H2052 Growth inhibition assay Inhibition of human NCI-H2052 cell growth in a cell viability assay. IC50=21.8963 μM SANGER
NCI-H292 Growth inhibition assay Inhibition of human NCI-H292 cell growth in a cell viability assay. IC50=0.0609 μM SANGER
NCI-H441 Growth inhibition assay Inhibition of human NCI-H441 cell growth in a cell viability assay. IC50=3.59841 μM SANGER
NCI-H2291 Growth inhibition assay Inhibition of human NCI-H2291 cell growth in a cell viability assay. IC50=5.98943 μM SANGER
NCI-H358 Growth inhibition assay Inhibition of human NCI-H358 cell growth in a cell viability assay. IC50=0.5321 μM SANGER
NCI-H460 Growth inhibition assay Inhibition of human NCI-H460 cell growth in a cell viability assay. IC50=46.523 μM SANGER
NCI-H661 Growth inhibition assay Inhibition of human NCI-H661 cell growth in a cell viability assay. IC50=16.9694 μM SANGER
NCI-H23 Growth inhibition assay Inhibition of human NCI-H23 cell growth in a cell viability assay. IC50=37.4196 μM SANGER
NCI-H630 Growth inhibition assay Inhibition of human NCI-H630 cell growth in a cell viability assay. IC50=1.45582 μM SANGER
NCI-H2342 Growth inhibition assay Inhibition of human NCI-H2342 cell growth in a cell viability assay. IC50=17.557 μM SANGER
NCI-H69 Growth inhibition assay Inhibition of human NCI-H69 cell growth in a cell viability assay. IC50=0.21451 μM SANGER
NCI-H650 Growth inhibition assay Inhibition of human NCI-H650 cell growth in a cell viability assay. IC50=11.2418 μM SANGER
NCI-H747 Growth inhibition assay Inhibition of human NCI-H747 cell growth in a cell viability assay. IC50=5.42472 μM SANGER
NCI-H2405 Growth inhibition assay Inhibition of human NCI-H2405 cell growth in a cell viability assay. IC50=17.1974 μM SANGER
NCI-H520 Growth inhibition assay Inhibition of human NCI-H520 cell growth in a cell viability assay. IC50=24.8861 μM SANGER
NCI-H810 Growth inhibition assay Inhibition of human NCI-H810 cell growth in a cell viability assay. IC50=34.7278 μM SANGER
NCI-H720 Growth inhibition assay Inhibition of human NCI-H720 cell growth in a cell viability assay. IC50=0.05325 μM SANGER
NCI-SNU-1 Growth inhibition assay Inhibition of human NCI-SNU-1 cell growth in a cell viability assay. IC50=3.69735 μM SANGER
NH-12 Growth inhibition assay Inhibition of human NH-12 cell growth in a cell viability assay. IC50=7.72808 μM SANGER
NCI-SNU-5 Growth inhibition assay Inhibition of human NCI-SNU-5 cell growth in a cell viability assay. IC50=1.239 μM SANGER
NKM-1 Growth inhibition assay Inhibition of human NKM-1 cell growth in a cell viability assay. IC50=3.18744 μM SANGER
NCI-H526 Growth inhibition assay Inhibition of human NCI-H526 cell growth in a cell viability assay. IC50=0.07823 μM SANGER
NTERA-S-cl-D1 Growth inhibition assay Inhibition of human NTERA-S-cl-D1 cell growth in a cell viability assay. IC50=5.54537 μM SANGER
NMC-G1 Growth inhibition assay Inhibition of human NMC-G1 cell growth in a cell viability assay. IC50=12.9234 μM SANGER
NCI-H82 Growth inhibition assay Inhibition of human NCI-H82 cell growth in a cell viability assay. IC50=1.54006 μM SANGER
NCI-H1623 Growth inhibition assay Inhibition of human NCI-H1623 cell growth in a cell viability assay. IC50=0.08025 μM SANGER
NOMO-1 Growth inhibition assay Inhibition of human NOMO-1 cell growth in a cell viability assay. IC50=34.5703 μM SANGER
NCI-N87 Growth inhibition assay Inhibition of human NCI-N87 cell growth in a cell viability assay. IC50=0.02773 μM SANGER
NCI-H1650 Growth inhibition assay Inhibition of human NCI-H1650 cell growth in a cell viability assay. IC50=9.60946 μM SANGER
NCI-H1703 Growth inhibition assay Inhibition of human NCI-H1703 cell growth in a cell viability assay. IC50=9.34375 μM SANGER
NCI-H1755 Growth inhibition assay Inhibition of human NCI-H1755 cell growth in a cell viability assay. IC50=41.8725 μM SANGER
NCI-H1993 Growth inhibition assay Inhibition of human NCI-H1993 cell growth in a cell viability assay. IC50=8.33631 μM SANGER
NCI-H209 Growth inhibition assay Inhibition of human NCI-H209 cell growth in a cell viability assay. IC50=0.2046 μM SANGER
NCI-H2122 Growth inhibition assay Inhibition of human NCI-H2122 cell growth in a cell viability assay. IC50=34.3471 μM SANGER
NY Growth inhibition assay Inhibition of human NY cell growth in a cell viability assay. IC50=3.53655 μM SANGER
OAW-42 Growth inhibition assay Inhibition of human OAW-42 cell growth in a cell viability assay. IC50=3.50026 μM SANGER
OC-314 Growth inhibition assay Inhibition of human OC-314 cell growth in a cell viability assay. IC50=15.4714 μM SANGER
NCI-H2228 Growth inhibition assay Inhibition of human NCI-H2228 cell growth in a cell viability assay. IC50=32.6602 μM SANGER
OCI-AML2 Growth inhibition assay Inhibition of human OCI-AML2 cell growth in a cell viability assay. IC50=8.95481 μM SANGER
OCUB-M Growth inhibition assay Inhibition of human OCUB-M cell growth in a cell viability assay. IC50=3.76187 μM SANGER
OE33 Growth inhibition assay Inhibition of human OE33 cell growth in a cell viability assay. IC50=13.786 μM SANGER
NCI-H28 Growth inhibition assay Inhibition of human NCI-H28 cell growth in a cell viability assay. IC50=7.16405 μM SANGER
OS-RC-2 Growth inhibition assay Inhibition of human OS-RC-2 cell growth in a cell viability assay. IC50=9.0219 μM SANGER
ONS-76 Growth inhibition assay Inhibition of human ONS-76 cell growth in a cell viability assay. IC50=41.4709 μM SANGER
OVCAR-3 Growth inhibition assay Inhibition of human OVCAR-3 cell growth in a cell viability assay. IC50=2.67167 μM SANGER
OVCAR-4 Growth inhibition assay Inhibition of human OVCAR-4 cell growth in a cell viability assay. IC50=10.8835 μM SANGER
OVCAR-5 Growth inhibition assay Inhibition of human OVCAR-5 cell growth in a cell viability assay. IC50=13.1593 μM SANGER
P12-ICHIKAWA Growth inhibition assay Inhibition of human P12-ICHIKAWA cell growth in a cell viability assay. IC50=25.4785 μM SANGER
NCI-H446 Growth inhibition assay Inhibition of human NCI-H446 cell growth in a cell viability assay. IC50=37.4862 μM SANGER
NCI-H510A Growth inhibition assay Inhibition of human NCI-H510A cell growth in a cell viability assay. IC50=31.4006 μM SANGER
NCI-H596 Growth inhibition assay Inhibition of human NCI-H596 cell growth in a cell viability assay. IC50=12.0369 μM SANGER
PA-1 Growth inhibition assay Inhibition of human PA-1 cell growth in a cell viability assay. IC50=49.8335 μM SANGER
PC-14 Growth inhibition assay Inhibition of human PC-14 cell growth in a cell viability assay. IC50=0.05668 μM SANGER
PANC-03-27 Growth inhibition assay Inhibition of human PANC-03-27 cell growth in a cell viability assay. IC50=2.16631 μM SANGER
PANC-08-13 Growth inhibition assay Inhibition of human PANC-08-13 cell growth in a cell viability assay. IC50=1.16416 μM SANGER
NCI-H727 Growth inhibition assay Inhibition of human NCI-H727 cell growth in a cell viability assay. IC50=8.1042 μM SANGER
RD Growth inhibition assay Inhibition of human RD cell growth in a cell viability assay. IC50=29.5233 μM SANGER
QIMR-WIL Growth inhibition assay Inhibition of human QIMR-WIL cell growth in a cell viability assay. IC50=16.7105 μM SANGER
RERF-LC-MS Growth inhibition assay Inhibition of human RERF-LC-MS cell growth in a cell viability assay. IC50=17.5508 μM SANGER
RCC10RGB Growth inhibition assay Inhibition of human RCC10RGB cell growth in a cell viability assay. IC50=18.0559 μM SANGER
RH-18 Growth inhibition assay Inhibition of human RH-18 cell growth in a cell viability assay. IC50=18.0035 μM SANGER
RO82-W-1 Growth inhibition assay Inhibition of human RO82-W-1 cell growth in a cell viability assay. IC50=32.1604 μM SANGER
RKO Growth inhibition assay Inhibition of human RKO cell growth in a cell viability assay. IC50=14.5075 μM SANGER
RPMI-7951 Growth inhibition assay Inhibition of human RPMI-7951 cell growth in a cell viability assay. IC50=3.0759 μM SANGER
NEC8 Growth inhibition assay Inhibition of human NEC8 cell growth in a cell viability assay. IC50=14.5472 μM SANGER
RPMI-8226 Growth inhibition assay Inhibition of human RPMI-8226 cell growth in a cell viability assay. IC50=4.11631 μM SANGER
RS4-11 Growth inhibition assay Inhibition of human RS4-11 cell growth in a cell viability assay. IC50=12.1725 μM SANGER
RXF393 Growth inhibition assay Inhibition of human RXF393 cell growth in a cell viability assay. IC50=36.3785 μM SANGER
NOS-1 Growth inhibition assay Inhibition of human NOS-1 cell growth in a cell viability assay. IC50=11.711 μM SANGER
Ramos-2G6-4C10 Growth inhibition assay Inhibition of human Ramos-2G6-4C10 cell growth in a cell viability assay. IC50=14.0202 μM SANGER
S-117 Growth inhibition assay Inhibition of human S-117 cell growth in a cell viability assay. IC50=36.3008 μM SANGER
SCC-25 Growth inhibition assay Inhibition of human SCC-25 cell growth in a cell viability assay. IC50=0.84171 μM SANGER
SBC-1 Growth inhibition assay Inhibition of human SBC-1 cell growth in a cell viability assay. IC50=0.18959 μM SANGER
SCC-15 Growth inhibition assay Inhibition of human SCC-15 cell growth in a cell viability assay. IC50=1.39451 μM SANGER
SCC-4 Growth inhibition assay Inhibition of human SCC-4 cell growth in a cell viability assay. IC50=8.44059 μM SANGER
NUGC-3 Growth inhibition assay Inhibition of human NUGC-3 cell growth in a cell viability assay. IC50=0.38373 μM SANGER
SCC-9 Growth inhibition assay Inhibition of human SCC-9 cell growth in a cell viability assay. IC50=37.7838 μM SANGER
SCH Growth inhibition assay Inhibition of human SCH cell growth in a cell viability assay. IC50=18.6456 μM SANGER
OAW-28 Growth inhibition assay Inhibition of human OAW-28 cell growth in a cell viability assay. IC50=7.94578 μM SANGER
SF126 Growth inhibition assay Inhibition of human SF126 cell growth in a cell viability assay. IC50=23.6924 μM SANGER
SF295 Growth inhibition assay Inhibition of human SF295 cell growth in a cell viability assay. IC50=26.0425 μM SANGER
OE19 Growth inhibition assay Inhibition of human OE19 cell growth in a cell viability assay. IC50=1.71512 μM SANGER
SF539 Growth inhibition assay Inhibition of human SF539 cell growth in a cell viability assay. IC50=9.23562 μM SANGER
SH-4 Growth inhibition assay Inhibition of human SH-4 cell growth in a cell viability assay. IC50=32.1858 μM SANGER
SHP-77 Growth inhibition assay Inhibition of human SHP-77 cell growth in a cell viability assay. IC50=29.6182 μM SANGER
OMC-1 Growth inhibition assay Inhibition of human OMC-1 cell growth in a cell viability assay. IC50=2.08169 μM SANGER
SK-HEP-1 Growth inhibition assay Inhibition of human SK-HEP-1 cell growth in a cell viability assay. IC50=30.6326 μM SANGER
SJSA-1 Growth inhibition assay Inhibition of human SJSA-1 cell growth in a cell viability assay. IC50=27.0176 μM SANGER
OVCAR-8 Growth inhibition assay Inhibition of human OVCAR-8 cell growth in a cell viability assay. IC50=15.8861 μM SANGER
SK-LU-1 Growth inhibition assay Inhibition of human SK-LU-1 cell growth in a cell viability assay. IC50=40.6568 μM SANGER
SK-MEL-1 Growth inhibition assay Inhibition of human SK-MEL-1 cell growth in a cell viability assay. IC50=13.7135 μM SANGER
SK-MEL-24 Growth inhibition assay Inhibition of human SK-MEL-24 cell growth in a cell viability assay. IC50=11.2366 μM SANGER
P30-OHK Growth inhibition assay Inhibition of human P30-OHK cell growth in a cell viability assay. IC50=35.8752 μM SANGER
PANC-10-05 Growth inhibition assay Inhibition of human PANC-10-05 cell growth in a cell viability assay. IC50=14.6247 μM SANGER
SK-MEL-3 Growth inhibition assay Inhibition of human SK-MEL-3 cell growth in a cell viability assay. IC50=16.4787 μM SANGER
SK-MES-1 Growth inhibition assay Inhibition of human SK-MES-1 cell growth in a cell viability assay. IC50=1.11487 μM SANGER
PC-3 Growth inhibition assay Inhibition of human PC-3 cell growth in a cell viability assay. IC50=19.9604 μM SANGER
SK-NEP-1 Growth inhibition assay Inhibition of human SK-NEP-1 cell growth in a cell viability assay. IC50=1.17513 μM SANGER
SK-N-DZ Growth inhibition assay Inhibition of human SK-N-DZ cell growth in a cell viability assay. IC50=28.6885 μM SANGER
SK-OV-3 Growth inhibition assay Inhibition of human SK-OV-3 cell growth in a cell viability assay. IC50=8.71329 μM SANGER
PFSK-1 Growth inhibition assay Inhibition of human PFSK-1 cell growth in a cell viability assay. IC50=13.06 μM SANGER
SK-PN-DW Growth inhibition assay Inhibition of human SK-PN-DW cell growth in a cell viability assay. IC50=35.4369 μM SANGER
SK-UT-1 Growth inhibition assay Inhibition of human SK-UT-1 cell growth in a cell viability assay. IC50=13.1083 μM SANGER
RCM-1 Growth inhibition assay Inhibition of human RCM-1 cell growth in a cell viability assay. IC50=2.52938 μM SANGER
SKG-IIIa Growth inhibition assay Inhibition of human SKG-IIIa cell growth in a cell viability assay. IC50=3.52237 μM SANGER
SNU-387 Growth inhibition assay Inhibition of human SNU-387 cell growth in a cell viability assay. IC50=40.4553 μM SANGER
SNU-449 Growth inhibition assay Inhibition of human SNU-449 cell growth in a cell viability assay. IC50=3.65826 μM SANGER
RMG-I Growth inhibition assay Inhibition of human RMG-I cell growth in a cell viability assay. IC50=7.39296 μM SANGER
SNU-C2B Growth inhibition assay Inhibition of human SNU-C2B cell growth in a cell viability assay. IC50=2.68616 μM SANGER
RPMI-2650 Growth inhibition assay Inhibition of human RPMI-2650 cell growth in a cell viability assay. IC50=11.5885 μM SANGER
SW1116 Growth inhibition assay Inhibition of human SW1116 cell growth in a cell viability assay. IC50=1.01287 μM SANGER
SW13 Growth inhibition assay Inhibition of human SW13 cell growth in a cell viability assay. IC50=0.16216 μM SANGER
SW1463 Growth inhibition assay Inhibition of human SW1463 cell growth in a cell viability assay. IC50=15.0485 μM SANGER
RPMI-8866 Growth inhibition assay Inhibition of human RPMI-8866 cell growth in a cell viability assay. IC50=27.7562 μM SANGER
RT-112 Growth inhibition assay Inhibition of human RT-112 cell growth in a cell viability assay. IC50=22.8616 μM SANGER
SW1710 Growth inhibition assay Inhibition of human SW1710 cell growth in a cell viability assay. IC50=8.18515 μM SANGER
RVH-421 Growth inhibition assay Inhibition of human RVH-421 cell growth in a cell viability assay. IC50=35.7645 μM SANGER
SW626 Growth inhibition assay Inhibition of human SW626 cell growth in a cell viability assay. IC50=11.5755 μM SANGER
SW1990 Growth inhibition assay Inhibition of human SW1990 cell growth in a cell viability assay. IC50=16.1755 μM SANGER
SW756 Growth inhibition assay Inhibition of human SW756 cell growth in a cell viability assay. IC50=6.91176 μM SANGER
SW48 Growth inhibition assay Inhibition of human SW48 cell growth in a cell viability assay. IC50=1.25432 μM SANGER
SW620 Growth inhibition assay Inhibition of human SW620 cell growth in a cell viability assay. IC50=5.24964 μM SANGER
SAS Growth inhibition assay Inhibition of human SAS cell growth in a cell viability assay. IC50=0.48398 μM SANGER
SW837 Growth inhibition assay Inhibition of human SW837 cell growth in a cell viability assay. IC50=12.9028 μM SANGER
SW872 Growth inhibition assay Inhibition of human SW872 cell growth in a cell viability assay. IC50=42.6331 μM SANGER
SW900 Growth inhibition assay Inhibition of human SW900 cell growth in a cell viability assay. IC50=7.82121 μM SANGER
SW948 Growth inhibition assay Inhibition of human SW948 cell growth in a cell viability assay. IC50=46.4462 μM SANGER
SiHa Growth inhibition assay Inhibition of human SiHa cell growth in a cell viability assay. IC50=23.9327 μM SANGER
SW962 Growth inhibition assay Inhibition of human SW962 cell growth in a cell viability assay. IC50=5.62032 μM SANGER
T-24 Growth inhibition assay Inhibition of human T-24 cell growth in a cell viability assay. IC50=34.0205 μM SANGER
Saos-2 Growth inhibition assay Inhibition of human Saos-2 cell growth in a cell viability assay. IC50=19.1162 μM SANGER
T47D Growth inhibition assay Inhibition of human T47D cell growth in a cell viability assay. IC50=3.62217 μM SANGER
T98G Growth inhibition assay Inhibition of human T98G cell growth in a cell viability assay. IC50=27.5846 μM SANGER
T84 Growth inhibition assay Inhibition of human T84 cell growth in a cell viability assay. IC50=11.3907 μM SANGER
SF268 Growth inhibition assay Inhibition of human SF268 cell growth in a cell viability assay. IC50=29.5932 μM SANGER
22RV1 Growth inhibition assay Inhibition of human 22RV1 cell growth in a cell viability assay. IC50=34.1754 μM SANGER
TE-1 Growth inhibition assay Inhibition of human TE-1 cell growth in a cell viability assay. IC50=1.81475 μM SANGER
23132-87 Growth inhibition assay Inhibition of human 23132-87 cell growth in a cell viability assay. IC50=0.31923 μM SANGER
SJRH30 Growth inhibition assay Inhibition of human SJRH30 cell growth in a cell viability assay. IC50=30.2108 μM SANGER
5637 Growth inhibition assay Inhibition of human 5637 cell growth in a cell viability assay. IC50=1.0151 μM SANGER
647-V Growth inhibition assay Inhibition of human 647-V cell growth in a cell viability assay. IC50=3.98452 μM SANGER
639-V Growth inhibition assay Inhibition of human 639-V cell growth in a cell viability assay. IC50=31.5243 μM SANGER
769-P Growth inhibition assay Inhibition of human 769-P cell growth in a cell viability assay. IC50=2.29037 μM SANGER
8-MG-BA Growth inhibition assay Inhibition of human 8-MG-BA cell growth in a cell viability assay. IC50=36.9483 μM SANGER
8305C Growth inhibition assay Inhibition of human 8305C cell growth in a cell viability assay. IC50=3.75911 μM SANGER
SK-MEL-2 Growth inhibition assay Inhibition of human SK-MEL-2 cell growth in a cell viability assay. IC50=32.6527 μM SANGER
8505C Growth inhibition assay Inhibition of human 8505C cell growth in a cell viability assay. IC50=13.2067 μM SANGER
A204 Growth inhibition assay Inhibition of human A204 cell growth in a cell viability assay. IC50=32.5069 μM SANGER
A101D Growth inhibition assay Inhibition of human A101D cell growth in a cell viability assay. IC50=49.9425 μM SANGER
SK-MEL-28 Growth inhibition assay Inhibition of human SK-MEL-28 cell growth in a cell viability assay. IC50=19.3363 μM SANGER
SK-N-AS Growth inhibition assay Inhibition of human SK-N-AS cell growth in a cell viability assay. IC50=21.8275 μM SANGER
A2780 Growth inhibition assay Inhibition of human A2780 cell growth in a cell viability assay. IC50=2.06294 μM SANGER
A3-KAW Growth inhibition assay Inhibition of human A3-KAW cell growth in a cell viability assay. IC50=23.1003 μM SANGER
A4-Fuk Growth inhibition assay Inhibition of human A4-Fuk cell growth in a cell viability assay. IC50=22.1419 μM SANGER
A431 Growth inhibition assay Inhibition of human A431 cell growth in a cell viability assay. IC50=0.48233 μM SANGER
A388 Growth inhibition assay Inhibition of human A388 cell growth in a cell viability assay. IC50=0.36857 μM SANGER
SK-N-FI Growth inhibition assay Inhibition of human SK-N-FI cell growth in a cell viability assay. IC50=28.433 μM SANGER
A549 Growth inhibition assay Inhibition of human A549 cell growth in a cell viability assay. IC50=6.12553 μM SANGER
A673 Growth inhibition assay Inhibition of human A673 cell growth in a cell viability assay. IC50=41.5157 μM SANGER
ACN Growth inhibition assay Inhibition of human ACN cell growth in a cell viability assay. IC50=0.55094 μM SANGER
A704 Growth inhibition assay Inhibition of human A704 cell growth in a cell viability assay. IC50=18.4753 μM SANGER
SN12C Growth inhibition assay Inhibition of human SN12C cell growth in a cell viability assay. IC50=2.91964 μM SANGER
ALL-PO Growth inhibition assay Inhibition of human ALL-PO cell growth in a cell viability assay. IC50=11.2512 μM SANGER
ABC-1 Growth inhibition assay Inhibition of human ABC-1 cell growth in a cell viability assay. IC50=34.3693 μM SANGER
ACHN Growth inhibition assay Inhibition of human ACHN cell growth in a cell viability assay. IC50=0.31994 μM SANGER
AN3-CA Growth inhibition assay Inhibition of human AN3-CA cell growth in a cell viability assay. IC50=28.4395 μM SANGER
ATN-1 Growth inhibition assay Inhibition of human ATN-1 cell growth in a cell viability assay. IC50=33.1416 μM SANGER
AU565 Growth inhibition assay Inhibition of human AU565 cell growth in a cell viability assay. IC50=0.08504 μM SANGER
BALL-1 Growth inhibition assay Inhibition of human BALL-1 cell growth in a cell viability assay. IC50=9.21907 μM SANGER
BB65-RCC Growth inhibition assay Inhibition of human BB65-RCC cell growth in a cell viability assay. IC50=0.34593 μM SANGER
BB49-HNC Growth inhibition assay Inhibition of human BB49-HNC cell growth in a cell viability assay. IC50=43.2356 μM SANGER
SW1417 Growth inhibition assay Inhibition of human SW1417 cell growth in a cell viability assay. IC50=4.12147 μM SANGER
BHY Growth inhibition assay Inhibition of human BHY cell growth in a cell viability assay. IC50=0.28655 μM SANGER
BCPAP Growth inhibition assay Inhibition of human BCPAP cell growth in a cell viability assay. IC50=27.137 μM SANGER
BFTC-905 Growth inhibition assay Inhibition of human BFTC-905 cell growth in a cell viability assay. IC50=29.2706 μM SANGER
BE-13 Growth inhibition assay Inhibition of human BE-13 cell growth in a cell viability assay. IC50=7.98112 μM SANGER
BHT-101 Growth inhibition assay Inhibition of human BHT-101 cell growth in a cell viability assay. IC50=14.241 μM SANGER
SW1573 Growth inhibition assay Inhibition of human SW1573 cell growth in a cell viability assay. IC50=11.7294 μM SANGER
SW684 Growth inhibition assay Inhibition of human SW684 cell growth in a cell viability assay. IC50=19.1326 μM SANGER
BPH-1 Growth inhibition assay Inhibition of human BPH-1 cell growth in a cell viability assay. IC50=0.05988 μM SANGER
SW780 Growth inhibition assay Inhibition of human SW780 cell growth in a cell viability assay. IC50=25.3264 μM SANGER
BT-474 Growth inhibition assay Inhibition of human BT-474 cell growth in a cell viability assay. IC50=0.04986 μM SANGER
SW954 Growth inhibition assay Inhibition of human SW954 cell growth in a cell viability assay. IC50=1.20214 μM SANGER
C2BBe1 Growth inhibition assay Inhibition of human C2BBe1 cell growth in a cell viability assay. IC50=14.764 μM SANGER
BV-173 Growth inhibition assay Inhibition of human BV-173 cell growth in a cell viability assay. IC50=0.17596 μM SANGER
SW982 Growth inhibition assay Inhibition of human SW982 cell growth in a cell viability assay. IC50=18.2671 μM SANGER
Becker Growth inhibition assay Inhibition of human Becker cell growth in a cell viability assay. IC50=20.7201 μM SANGER
BxPC-3 Growth inhibition assay Inhibition of human BxPC-3 cell growth in a cell viability assay. IC50=10.0973 μM SANGER
C8166 Growth inhibition assay Inhibition of human C8166 cell growth in a cell viability assay. IC50=33.8854 μM SANGER
C-33-A Growth inhibition assay Inhibition of human C-33-A cell growth in a cell viability assay. IC50=0.81297 μM SANGER
C3A Growth inhibition assay Inhibition of human C3A cell growth in a cell viability assay. IC50=30.2927 μM SANGER
CAKI-1 Growth inhibition assay Inhibition of human CAKI-1 cell growth in a cell viability assay. IC50=1.78211 μM SANGER
TCCSUP Growth inhibition assay Inhibition of human TCCSUP cell growth in a cell viability assay. IC50=28.6418 μM SANGER
CAL-120 Growth inhibition assay Inhibition of human CAL-120 cell growth in a cell viability assay. IC50=15.1447 μM SANGER
CAL-12T Growth inhibition assay Inhibition of human CAL-12T cell growth in a cell viability assay. IC50=1.88945 μM SANGER
CAL-27 Growth inhibition assay Inhibition of human CAL-27 cell growth in a cell viability assay. IC50=0.17636 μM SANGER
CAL-51 Growth inhibition assay Inhibition of human CAL-51 cell growth in a cell viability assay. IC50=31.5667 μM SANGER
CAL-39 Growth inhibition assay Inhibition of human CAL-39 cell growth in a cell viability assay. IC50=0.11792 μM SANGER
CAL-54 Growth inhibition assay Inhibition of human CAL-54 cell growth in a cell viability assay. IC50=0.61621 μM SANGER
697 Growth inhibition assay Inhibition of human 697 cell growth in a cell viability assay. IC50=28.6331 μM SANGER
CAL-85-1 Growth inhibition assay Inhibition of human CAL-85-1 cell growth in a cell viability assay. IC50=9.87383 μM SANGER
CAL-62 Growth inhibition assay Inhibition of human CAL-62 cell growth in a cell viability assay. IC50=43.4028 μM SANGER
CAL-72 Growth inhibition assay Inhibition of human CAL-72 cell growth in a cell viability assay. IC50=10.9391 μM SANGER
786-0 Growth inhibition assay Inhibition of human 786-0 cell growth in a cell viability assay. IC50=3.06408 μM SANGER
TE-11 Growth inhibition assay Inhibition of human TE-11 cell growth in a cell viability assay. IC50=26.7752 μM SANGER
A172 Growth inhibition assay Inhibition of human A172 cell growth in a cell viability assay. IC50=12.0798 μM SANGER
TE-5 Growth inhibition assay Inhibition of human TE-5 cell growth in a cell viability assay. IC50=5.4085 μM SANGER
TE-6 Growth inhibition assay Inhibition of human TE-6 cell growth in a cell viability assay. IC50=0.40246 μM SANGER
TE-9 Growth inhibition assay Inhibition of human TE-9 cell growth in a cell viability assay. IC50=3.84382 μM SANGER
TGBC24TKB Growth inhibition assay Inhibition of human TGBC24TKB cell growth in a cell viability assay. IC50=1.6823 μM SANGER
A2058 Growth inhibition assay Inhibition of human A2058 cell growth in a cell viability assay. IC50=15.0409 μM SANGER
TI-73 Growth inhibition assay Inhibition of human TI-73 cell growth in a cell viability assay. IC50=0.14715 μM SANGER
A427 Growth inhibition assay Inhibition of human A427 cell growth in a cell viability assay. IC50=37.9107 μM SANGER
TK10 Growth inhibition assay Inhibition of human TK10 cell growth in a cell viability assay. IC50=0.26738 μM SANGER
TGBC1TKB Growth inhibition assay Inhibition of human TGBC1TKB cell growth in a cell viability assay. IC50=30.1238 μM SANGER
A498 Growth inhibition assay Inhibition of human A498 cell growth in a cell viability assay. IC50=0.40674 μM SANGER
AGS Growth inhibition assay Inhibition of human AGS cell growth in a cell viability assay. IC50=0.83648 μM SANGER
U-2-OS Growth inhibition assay Inhibition of human U-2-OS cell growth in a cell viability assay. IC50=17.5307 μM SANGER
U-118-MG Growth inhibition assay Inhibition of human U-118-MG cell growth in a cell viability assay. IC50=36.8847 μM SANGER
U-266 Growth inhibition assay Inhibition of human U-266 cell growth in a cell viability assay. IC50=16.2299 μM SANGER
U031 Growth inhibition assay Inhibition of human U031 cell growth in a cell viability assay. IC50=5.25424 μM SANGER
UACC-257 Growth inhibition assay Inhibition of human UACC-257 cell growth in a cell viability assay. IC50=41.7369 μM SANGER
U-87-MG Growth inhibition assay Inhibition of human U-87-MG cell growth in a cell viability assay. IC50=4.10481 μM SANGER
AsPC-1 Growth inhibition assay Inhibition of human AsPC-1 cell growth in a cell viability assay. IC50=19.6471 μM SANGER
UACC-893 Growth inhibition assay Inhibition of human UACC-893 cell growth in a cell viability assay. IC50=0.11885 μM SANGER
BB30-HNC Growth inhibition assay Inhibition of human BB30-HNC cell growth in a cell viability assay. IC50=0.16576 μM SANGER
UM-UC-3 Growth inhibition assay Inhibition of human UM-UC-3 cell growth in a cell viability assay. IC50=9.9503 μM SANGER
VM-CUB-1 Growth inhibition assay Inhibition of human VM-CUB-1 cell growth in a cell viability assay. IC50=4.86819 μM SANGER
UMC-11 Growth inhibition assay Inhibition of human UMC-11 cell growth in a cell viability assay. IC50=26.4514 μM SANGER
BEN Growth inhibition assay Inhibition of human BEN cell growth in a cell viability assay. IC50=27.8517 μM SANGER
WM-115 Growth inhibition assay Inhibition of human WM-115 cell growth in a cell viability assay. IC50=11.7588 μM SANGER
BFTC-909 Growth inhibition assay Inhibition of human BFTC-909 cell growth in a cell viability assay. IC50=9.06799 μM SANGER
YAPC Growth inhibition assay Inhibition of human YAPC cell growth in a cell viability assay. IC50=11.9259 μM SANGER
BT-20 Growth inhibition assay Inhibition of human BT-20 cell growth in a cell viability assay. IC50=3.69795 μM SANGER
YKG-1 Growth inhibition assay Inhibition of human YKG-1 cell growth in a cell viability assay. IC50=1.05419 μM SANGER
CAPAN-1 Growth inhibition assay Inhibition of human CAPAN-1 cell growth in a cell viability assay. IC50=30.5181 μM SANGER
no-10 Growth inhibition assay Inhibition of human no-10 cell growth in a cell viability assay. IC50=16.6343 μM SANGER
CAMA-1 Growth inhibition assay Inhibition of human CAMA-1 cell growth in a cell viability assay. IC50=9.28128 μM SANGER
CAS-1 Growth inhibition assay Inhibition of human CAS-1 cell growth in a cell viability assay. IC50=46.7701 μM SANGER
BT-549 Growth inhibition assay Inhibition of human BT-549 cell growth in a cell viability assay. IC50=6.66889 μM SANGER
CCRF-CEM Growth inhibition assay Inhibition of human CCRF-CEM cell growth in a cell viability assay. IC50=25.967 μM SANGER
CGTH-W-1 Growth inhibition assay Inhibition of human CGTH-W-1 cell growth in a cell viability assay. IC50=42.4955 μM SANGER
CHP-212 Growth inhibition assay Inhibition of human CHP-212 cell growth in a cell viability assay. IC50=22.3222 μM SANGER
C32 Growth inhibition assay Inhibition of human C32 cell growth in a cell viability assay. IC50=9.33064 μM SANGER
COLO-320-HSR Growth inhibition assay Inhibition of human COLO-320-HSR cell growth in a cell viability assay. IC50=18.746 μM SANGER
CAL-33 Growth inhibition assay Inhibition of human CAL-33 cell growth in a cell viability assay. IC50=0.20184 μM SANGER
COLO-678 Growth inhibition assay Inhibition of human COLO-678 cell growth in a cell viability assay. IC50=0.80834 μM SANGER
COLO-680N Growth inhibition assay Inhibition of human COLO-680N cell growth in a cell viability assay. IC50=44.339 μM SANGER
COLO-684 Growth inhibition assay Inhibition of human COLO-684 cell growth in a cell viability assay. IC50=16.9477 μM SANGER
TE-10 Growth inhibition assay Inhibition of human TE-10 cell growth in a cell viability assay. IC50=2.68078 μM SANGER
COLO-741 Growth inhibition assay Inhibition of human COLO-741 cell growth in a cell viability assay. IC50=20.66 μM SANGER
COLO-792 Growth inhibition assay Inhibition of human COLO-792 cell growth in a cell viability assay. IC50=25.2732 μM SANGER
TE-12 Growth inhibition assay Inhibition of human TE-12 cell growth in a cell viability assay. IC50=1.80414 μM SANGER
COR-L23 Growth inhibition assay Inhibition of human COR-L23 cell growth in a cell viability assay. IC50=24.1767 μM SANGER
COLO-824 Growth inhibition assay Inhibition of human COLO-824 cell growth in a cell viability assay. IC50=15.1579 μM SANGER
COR-L105 Growth inhibition assay Inhibition of human COR-L105 cell growth in a cell viability assay. IC50=0.21084 μM SANGER
COR-L88 Growth inhibition assay Inhibition of human COR-L88 cell growth in a cell viability assay. IC50=0.64113 μM SANGER
TE-8 Growth inhibition assay Inhibition of human TE-8 cell growth in a cell viability assay. IC50=1.91377 μM SANGER
TGBC11TKB Growth inhibition assay Inhibition of human TGBC11TKB cell growth in a cell viability assay. IC50=47.1777 μM SANGER
CP50-MEL-B Growth inhibition assay Inhibition of human CP50-MEL-B cell growth in a cell viability assay. IC50=17.0343 μM SANGER
CP66-MEL Growth inhibition assay Inhibition of human CP66-MEL cell growth in a cell viability assay. IC50=15.4688 μM SANGER
CTB-1 Growth inhibition assay Inhibition of human CTB-1 cell growth in a cell viability assay. IC50=4.8488 μM SANGER
CaR-1 Growth inhibition assay Inhibition of human CaR-1 cell growth in a cell viability assay. IC50=2.28281 μM SANGER
CTV-1 Growth inhibition assay Inhibition of human CTV-1 cell growth in a cell viability assay. IC50=0.64392 μM SANGER
CW-2 Growth inhibition assay Inhibition of human CW-2 cell growth in a cell viability assay. IC50=0.46914 μM SANGER
Ca-Ski Growth inhibition assay Inhibition of human Ca-Ski cell growth in a cell viability assay. IC50=7.64259 μM SANGER
U251 Growth inhibition assay Inhibition of human U251 cell growth in a cell viability assay. IC50=40.4054 μM SANGER
Ca9-22 Growth inhibition assay Inhibition of human Ca9-22 cell growth in a cell viability assay. IC50=0.08353 μM SANGER
Calu-3 Growth inhibition assay Inhibition of human Calu-3 cell growth in a cell viability assay. IC50=0.81434 μM SANGER
Capan-2 Growth inhibition assay Inhibition of human Capan-2 cell growth in a cell viability assay. IC50=3.46875 μM SANGER
UACC-62 Growth inhibition assay Inhibition of human UACC-62 cell growth in a cell viability assay. IC50=11.2368 μM SANGER
ChaGo-K-1 Growth inhibition assay Inhibition of human ChaGo-K-1 cell growth in a cell viability assay. IC50=32.007 μM SANGER
VA-ES-BJ Growth inhibition assay Inhibition of human VA-ES-BJ cell growth in a cell viability assay. IC50=35.4648 μM SANGER
D-263MG Growth inhibition assay Inhibition of human D-263MG cell growth in a cell viability assay. IC50=33.8378 μM SANGER
VMRC-RCZ Growth inhibition assay Inhibition of human VMRC-RCZ cell growth in a cell viability assay. IC50=8.01697 μM SANGER
D-336MG Growth inhibition assay Inhibition of human D-336MG cell growth in a cell viability assay. IC50=30.2892 μM SANGER
D-392MG Growth inhibition assay Inhibition of human D-392MG cell growth in a cell viability assay. IC50=35.0565 μM SANGER
D-566MG Growth inhibition assay Inhibition of human D-566MG cell growth in a cell viability assay. IC50=29.9393 μM SANGER
D-423MG Growth inhibition assay Inhibition of human D-423MG cell growth in a cell viability assay. IC50=5.61705 μM SANGER
DBTRG-05MG Growth inhibition assay Inhibition of human DBTRG-05MG cell growth in a cell viability assay. IC50=13.0633 μM SANGER
D-502MG Growth inhibition assay Inhibition of human D-502MG cell growth in a cell viability assay. IC50=8.29282 μM SANGER
ZR-75-30 Growth inhibition assay Inhibition of human ZR-75-30 cell growth in a cell viability assay. IC50=0.09545 μM SANGER
D-542MG Growth inhibition assay Inhibition of human D-542MG cell growth in a cell viability assay. IC50=1.01064 μM SANGER
DMS-273 Growth inhibition assay Inhibition of human DMS-273 cell growth in a cell viability assay. IC50=32.5322 μM SANGER
DJM-1 Growth inhibition assay Inhibition of human DJM-1 cell growth in a cell viability assay. IC50=6.92012 μM SANGER
DK-MG Growth inhibition assay Inhibition of human DK-MG cell growth in a cell viability assay. IC50=30.5456 μM SANGER
no-11 Growth inhibition assay Inhibition of human no-11 cell growth in a cell viability assay. IC50=3.53564 μM SANGER
DMS-114 Growth inhibition assay Inhibition of human DMS-114 cell growth in a cell viability assay. IC50=40.8374 μM SANGER
DMS-79 Growth inhibition assay Inhibition of human DMS-79 cell growth in a cell viability assay. IC50=40.5889 μM SANGER
DOK Growth inhibition assay Inhibition of human DOK cell growth in a cell viability assay. IC50=0.03194 μM SANGER
CFPAC-1 Growth inhibition assay Inhibition of human CFPAC-1 cell growth in a cell viability assay. IC50=1.42493 μM SANGER
DSH1 Growth inhibition assay Inhibition of human DSH1 cell growth in a cell viability assay. IC50=0.03314 μM SANGER
DU-145 Growth inhibition assay Inhibition of human DU-145 cell growth in a cell viability assay. IC50=0.44833 μM SANGER
CHL-1 Growth inhibition assay Inhibition of human CHL-1 cell growth in a cell viability assay. IC50=0.01839 μM SANGER
DU-4475 Growth inhibition assay Inhibition of human DU-4475 cell growth in a cell viability assay. IC50=1.40121 μM SANGER
DoTc2-4510 Growth inhibition assay Inhibition of human DoTc2-4510 cell growth in a cell viability assay. IC50=0.32219 μM SANGER
Daoy Growth inhibition assay Inhibition of human Daoy cell growth in a cell viability assay. IC50=24.126 μM SANGER
Detroit562 Growth inhibition assay Inhibition of human Detroit562 cell growth in a cell viability assay. IC50=1.70152 μM SANGER
ECC10 Growth inhibition assay Inhibition of human ECC10 cell growth in a cell viability assay. IC50=1.55369 μM SANGER
EC-GI-10 Growth inhibition assay Inhibition of human EC-GI-10 cell growth in a cell viability assay. IC50=0.05912 μM SANGER
EFM-19 Growth inhibition assay Inhibition of human EFM-19 cell growth in a cell viability assay. IC50=37.7967 μM SANGER
COLO-679 Growth inhibition assay Inhibition of human COLO-679 cell growth in a cell viability assay. IC50=35.388 μM SANGER
EFO-21 Growth inhibition assay Inhibition of human EFO-21 cell growth in a cell viability assay. IC50=11.1045 μM SANGER
EFO-27 Growth inhibition assay Inhibition of human EFO-27 cell growth in a cell viability assay. IC50=0.05182 μM SANGER
EKVX Growth inhibition assay Inhibition of human EKVX cell growth in a cell viability assay. IC50=1.01064 μM SANGER
EGI-1 Growth inhibition assay Inhibition of human EGI-1 cell growth in a cell viability assay. IC50=28.5928 μM SANGER
EPLC-272H Growth inhibition assay Inhibition of human EPLC-272H cell growth in a cell viability assay. IC50=4.41533 μM SANGER
COLO-800 Growth inhibition assay Inhibition of human COLO-800 cell growth in a cell viability assay. IC50=7.41446 μM SANGER
COLO-829 Growth inhibition assay Inhibition of human COLO-829 cell growth in a cell viability assay. IC50=8.80976 μM SANGER
ES3 Growth inhibition assay Inhibition of human ES3 cell growth in a cell viability assay. IC50=16.9134 μM SANGER
ES8 Growth inhibition assay Inhibition of human ES8 cell growth in a cell viability assay. IC50=17.6087 μM SANGER
ES4 Growth inhibition assay Inhibition of human ES4 cell growth in a cell viability assay. IC50=0.97836 μM SANGER
ETK-1 Growth inhibition assay Inhibition of human ETK-1 cell growth in a cell viability assay. IC50=1.37456 μM SANGER
EW-1 Growth inhibition assay Inhibition of human EW-1 cell growth in a cell viability assay. IC50=45.9689 μM SANGER
ES5 Growth inhibition assay Inhibition of human ES5 cell growth in a cell viability assay. IC50=4.83723 μM SANGER
EW-11 Growth inhibition assay Inhibition of human EW-11 cell growth in a cell viability assay. IC50=9.17653 μM SANGER
EW-13 Growth inhibition assay Inhibition of human EW-13 cell growth in a cell viability assay. IC50=14.0352 μM SANGER
EW-18 Growth inhibition assay Inhibition of human EW-18 cell growth in a cell viability assay. IC50=0.68698 μM SANGER
EW-3 Growth inhibition assay Inhibition of human EW-3 cell growth in a cell viability assay. IC50=1.07883 μM SANGER
EW-24 Growth inhibition assay Inhibition of human EW-24 cell growth in a cell viability assay. IC50=21.3945 μM SANGER
Calu-6 Growth inhibition assay Inhibition of human Calu-6 cell growth in a cell viability assay. IC50=30.2963 μM SANGER
FTC-133 Growth inhibition assay Inhibition of human FTC-133 cell growth in a cell viability assay. IC50=11.1407 μM SANGER
EoL-1-cell Growth inhibition assay Inhibition of human EoL-1-cell cell growth in a cell viability assay. IC50=0.26892 μM SANGER
FADU Growth inhibition assay Inhibition of human FADU cell growth in a cell viability assay. IC50=0.54404 μM SANGER
G-401 Growth inhibition assay Inhibition of human G-401 cell growth in a cell viability assay. IC50=1.67413 μM SANGER
GAK Growth inhibition assay Inhibition of human GAK cell growth in a cell viability assay. IC50=25.2963 μM SANGER
GAMG Growth inhibition assay Inhibition of human GAMG cell growth in a cell viability assay. IC50=3.91314 μM SANGER
GMS-10 Growth inhibition assay Inhibition of human GMS-10 cell growth in a cell viability assay. IC50=2.03517 μM SANGER
GB-1 Growth inhibition assay Inhibition of human GB-1 cell growth in a cell viability assay. IC50=25.4068 μM SANGER
GI-ME-N Growth inhibition assay Inhibition of human GI-ME-N cell growth in a cell viability assay. IC50=31.0571 μM SANGER
GOTO Growth inhibition assay Inhibition of human GOTO cell growth in a cell viability assay. IC50=31.8506 μM SANGER
GCIY Growth inhibition assay Inhibition of human GCIY cell growth in a cell viability assay. IC50=1.08104 μM SANGER
GT3TKB Growth inhibition assay Inhibition of human GT3TKB cell growth in a cell viability assay. IC50=8.67964 μM SANGER
GP5d Growth inhibition assay Inhibition of human GP5d cell growth in a cell viability assay. IC50=6.97394 μM SANGER
D-283MED Growth inhibition assay Inhibition of human D-283MED cell growth in a cell viability assay. IC50=18.0088 μM SANGER
GR-ST Growth inhibition assay Inhibition of human GR-ST cell growth in a cell viability assay. IC50=28.6696 μM SANGER
DB Growth inhibition assay Inhibition of human DB cell growth in a cell viability assay. IC50=7.61005 μM SANGER
HC-1 Growth inhibition assay Inhibition of human HC-1 cell growth in a cell viability assay. IC50=5.51839 μM SANGER
HAL-01 Growth inhibition assay Inhibition of human HAL-01 cell growth in a cell viability assay. IC50=8.5191 μM SANGER
HCC1187 Growth inhibition assay Inhibition of human HCC1187 cell growth in a cell viability assay. IC50=20.6734 μM SANGER
HCC1419 Growth inhibition assay Inhibition of human HCC1419 cell growth in a cell viability assay. IC50=0.36408 μM SANGER
HCC1395 Growth inhibition assay Inhibition of human HCC1395 cell growth in a cell viability assay. IC50=14.9338 μM SANGER
DEL Growth inhibition assay Inhibition of human DEL cell growth in a cell viability assay. IC50=10.3946 μM SANGER
DOHH-2 Growth inhibition assay Inhibition of human DOHH-2 cell growth in a cell viability assay. IC50=20.5463 μM SANGER
HCC1937 Growth inhibition assay Inhibition of human HCC1937 cell growth in a cell viability assay. IC50=12.7564 μM SANGER
HCC38 Growth inhibition assay Inhibition of human HCC38 cell growth in a cell viability assay. IC50=42.9618 μM SANGER
HCC1954 Growth inhibition assay Inhibition of human HCC1954 cell growth in a cell viability assay. IC50=11.0754 μM SANGER
HCC2218 Growth inhibition assay Inhibition of human HCC2218 cell growth in a cell viability assay. IC50=0.009869 μM SANGER
HCE-4 Growth inhibition assay Inhibition of human HCE-4 cell growth in a cell viability assay. IC50=9.21558 μM SANGER
HCE-T Growth inhibition assay Inhibition of human HCE-T cell growth in a cell viability assay. IC50=0.88428 μM SANGER
HL-60 Growth inhibition assay Inhibition of human HL-60 cell growth in a cell viability assay. IC50=4.86611 μM SANGER
HCT-116 Growth inhibition assay Inhibition of human HCT-116 cell growth in a cell viability assay. IC50=4.41007 μM SANGER
HEL Growth inhibition assay Inhibition of human HEL cell growth in a cell viability assay. IC50=7.71203 μM SANGER
HCT-15 Growth inhibition assay Inhibition of human HCT-15 cell growth in a cell viability assay. IC50=22.7441 μM SANGER
HLE Growth inhibition assay Inhibition of human HLE cell growth in a cell viability assay. IC50=0.35046 μM SANGER
HH Growth inhibition assay Inhibition of human HH cell growth in a cell viability assay. IC50=16.5162 μM SANGER
HD-MY-Z Growth inhibition assay Inhibition of human HD-MY-Z cell growth in a cell viability assay. IC50=48.786 μM SANGER
HO-1-N-1 Growth inhibition assay Inhibition of human HO-1-N-1 cell growth in a cell viability assay. IC50=0.27853 μM SANGER
HN Growth inhibition assay Inhibition of human HN cell growth in a cell viability assay. IC50=0.13077 μM SANGER
HDLM-2 Growth inhibition assay Inhibition of human HDLM-2 cell growth in a cell viability assay. IC50=0.00572 μM SANGER
EM-2 Growth inhibition assay Inhibition of human EM-2 cell growth in a cell viability assay. IC50=14.8576 μM SANGER
HOP-92 Growth inhibition assay Inhibition of human HOP-92 cell growth in a cell viability assay. IC50=26.1226 μM SANGER
HPAF-II Growth inhibition assay Inhibition of human HPAF-II cell growth in a cell viability assay. IC50=41.6709 μM SANGER
HSC-2 Growth inhibition assay Inhibition of human HSC-2 cell growth in a cell viability assay. IC50=0.16837 μM SANGER
ES1 Growth inhibition assay Inhibition of human ES1 cell growth in a cell viability assay. IC50=19.9213 μM SANGER
HSC-3 Growth inhibition assay Inhibition of human HSC-3 cell growth in a cell viability assay. IC50=0.21198 μM SANGER
HSC-4 Growth inhibition assay Inhibition of human HSC-4 cell growth in a cell viability assay. IC50=0.01748 μM SANGER
ES7 Growth inhibition assay Inhibition of human ES7 cell growth in a cell viability assay. IC50=19.6292 μM SANGER
HT-144 Growth inhibition assay Inhibition of human HT-144 cell growth in a cell viability assay. IC50=27.4032 μM SANGER
ESS-1 Growth inhibition assay Inhibition of human ESS-1 cell growth in a cell viability assay. IC50=18.5206 μM SANGER
HT-29 Growth inhibition assay Inhibition of human HT-29 cell growth in a cell viability assay. IC50=3.07309 μM SANGER
HT-3 Growth inhibition assay Inhibition of human HT-3 cell growth in a cell viability assay. IC50=1.28753 μM SANGER
HT55 Growth inhibition assay Inhibition of human HT55 cell growth in a cell viability assay. IC50=2.5738 μM SANGER
EW-16 Growth inhibition assay Inhibition of human EW-16 cell growth in a cell viability assay. IC50=27.2947 μM SANGER
HTC-C3 Growth inhibition assay Inhibition of human HTC-C3 cell growth in a cell viability assay. IC50=27.2561 μM SANGER
HT-1376 Growth inhibition assay Inhibition of human HT-1376 cell growth in a cell viability assay. IC50=1.01513 μM SANGER
EW-22 Growth inhibition assay Inhibition of human EW-22 cell growth in a cell viability assay. IC50=41.8697 μM SANGER
Hs-578-T Growth inhibition assay Inhibition of human Hs-578-T cell growth in a cell viability assay. IC50=45.0294 μM SANGER
G-361 Growth inhibition assay Inhibition of human G-361 cell growth in a cell viability assay. IC50=26.1027 μM SANGER
HuH-7 Growth inhibition assay Inhibition of human HuH-7 cell growth in a cell viability assay. IC50=28.4028 μM SANGER
HuO-3N1 Growth inhibition assay Inhibition of human HuO-3N1 cell growth in a cell viability assay. IC50=5.24043 μM SANGER
HuO9 Growth inhibition assay Inhibition of human HuO9 cell growth in a cell viability assay. IC50=11.8774 μM SANGER
G-402 Growth inhibition assay Inhibition of human G-402 cell growth in a cell viability assay. IC50=35.9867 μM SANGER
IGROV-1 Growth inhibition assay Inhibition of human IGROV-1 cell growth in a cell viability assay. IC50=0.25952 μM SANGER
HuP-T3 Growth inhibition assay Inhibition of human HuP-T3 cell growth in a cell viability assay. IC50=16.6576 μM SANGER
HuP-T4 Growth inhibition assay Inhibition of human HuP-T4 cell growth in a cell viability assay. IC50=0.6976 μM SANGER
GCT Growth inhibition assay Inhibition of human GCT cell growth in a cell viability assay. IC50=20.3026 μM SANGER
IST-MEL1 Growth inhibition assay Inhibition of human IST-MEL1 cell growth in a cell viability assay. IC50=11.456 μM SANGER
GI-1 Growth inhibition assay Inhibition of human GI-1 cell growth in a cell viability assay. IC50=22.7658 μM SANGER
IST-MES1 Growth inhibition assay Inhibition of human IST-MES1 cell growth in a cell viability assay. IC50=18.4428 μM SANGER
J82 Growth inhibition assay Inhibition of human J82 cell growth in a cell viability assay. IC50=15.057 μM SANGER
JAR Growth inhibition assay Inhibition of human JAR cell growth in a cell viability assay. IC50=19.299 μM SANGER
H-EMC-SS Growth inhibition assay Inhibition of human H-EMC-SS cell growth in a cell viability assay. IC50=32.9678 μM SANGER
JEG-3 Growth inhibition assay Inhibition of human JEG-3 cell growth in a cell viability assay. IC50=22.378 μM SANGER
JVM-2 Growth inhibition assay Inhibition of human JVM-2 cell growth in a cell viability assay. IC50=0.88299 μM SANGER
H9 Growth inhibition assay Inhibition of human H9 cell growth in a cell viability assay. IC50=0.07132 μM SANGER
KARPAS-299 Growth inhibition assay Inhibition of human KARPAS-299 cell growth in a cell viability assay. IC50=20.3422 μM SANGER
JVM-3 Growth inhibition assay Inhibition of human JVM-3 cell growth in a cell viability assay. IC50=7.89599 μM SANGER
KALS-1 Growth inhibition assay Inhibition of human KALS-1 cell growth in a cell viability assay. IC50=23.1414 μM SANGER
HCC1569 Growth inhibition assay Inhibition of human HCC1569 cell growth in a cell viability assay. IC50=2.58297 μM SANGER
KARPAS-45 Growth inhibition assay Inhibition of human KARPAS-45 cell growth in a cell viability assay. IC50=0.01671 μM SANGER
KE-37 Growth inhibition assay Inhibition of human KE-37 cell growth in a cell viability assay. IC50=25.7315 μM SANGER
KASUMI-1 Growth inhibition assay Inhibition of human KASUMI-1 cell growth in a cell viability assay. IC50=0.00911 μM SANGER
KGN Growth inhibition assay Inhibition of human KGN cell growth in a cell viability assay. IC50=32.633 μM SANGER
KLE Growth inhibition assay Inhibition of human KLE cell growth in a cell viability assay. IC50=4.40819 μM SANGER
HCC1806 Growth inhibition assay Inhibition of human HCC1806 cell growth in a cell viability assay. IC50=0.69666 μM SANGER
KM-H2 Growth inhibition assay Inhibition of human KM-H2 cell growth in a cell viability assay. IC50=34.1779 μM SANGER
KM12 Growth inhibition assay Inhibition of human KM12 cell growth in a cell viability assay. IC50=22.356 μM SANGER
HCC2998 Growth inhibition assay Inhibition of human HCC2998 cell growth in a cell viability assay. IC50=5.52615 μM SANGER
KNS-42 Growth inhibition assay Inhibition of human KNS-42 cell growth in a cell viability assay. IC50=35.5826 μM SANGER
KMOE-2 Growth inhibition assay Inhibition of human KMOE-2 cell growth in a cell viability assay. IC50=19.2242 μM SANGER
HCC70 Growth inhibition assay Inhibition of human HCC70 cell growth in a cell viability assay. IC50=0.57661 μM SANGER
HEC-1 Growth inhibition assay Inhibition of human HEC-1 cell growth in a cell viability assay. IC50=3.5895 μM SANGER
KP-4 Growth inhibition assay Inhibition of human KP-4 cell growth in a cell viability assay. IC50=42.8832 μM SANGER
KNS-81-FD Growth inhibition assay Inhibition of human KNS-81-FD cell growth in a cell viability assay. IC50=19.5468 μM SANGER
HGC-27 Growth inhibition assay Inhibition of human HGC-27 cell growth in a cell viability assay. IC50=31.5873 μM SANGER
KP-N-YN Growth inhibition assay Inhibition of human KP-N-YN cell growth in a cell viability assay. IC50=37.6195 μM SANGER
KP-N-YS Growth inhibition assay Inhibition of human KP-N-YS cell growth in a cell viability assay. IC50=40.6768 μM SANGER
KU-19-19 Growth inhibition assay Inhibition of human KU-19-19 cell growth in a cell viability assay. IC50=0.77464 μM SANGER
HOP-62 Growth inhibition assay Inhibition of human HOP-62 cell growth in a cell viability assay. IC50=11.6764 μM SANGER
HOS Growth inhibition assay Inhibition of human HOS cell growth in a cell viability assay. IC50=39.6273 μM SANGER
KURAMOCHI Growth inhibition assay Inhibition of human KURAMOCHI cell growth in a cell viability assay. IC50=7.94811 μM SANGER
KY821 Growth inhibition assay Inhibition of human KY821 cell growth in a cell viability assay. IC50=0.0206 μM SANGER
KYSE-270 Growth inhibition assay Inhibition of human KYSE-270 cell growth in a cell viability assay. IC50=2.02732 μM SANGER
KYSE-140 Growth inhibition assay Inhibition of human KYSE-140 cell growth in a cell viability assay. IC50=0.0833 μM SANGER
KYSE-150 Growth inhibition assay Inhibition of human KYSE-150 cell growth in a cell viability assay. IC50=42.1782 μM SANGER
KYSE-450 Growth inhibition assay Inhibition of human KYSE-450 cell growth in a cell viability assay. IC50=0.05978 μM SANGER
HT Growth inhibition assay Inhibition of human HT cell growth in a cell viability assay. IC50=40.6639 μM SANGER
KYSE-180 Growth inhibition assay Inhibition of human KYSE-180 cell growth in a cell viability assay. IC50=0.39089 μM SANGER
HT-1197 Growth inhibition assay Inhibition of human HT-1197 cell growth in a cell viability assay. IC50=4.52669 μM SANGER
KYSE-520 Growth inhibition assay Inhibition of human KYSE-520 cell growth in a cell viability assay. IC50=5.20839 μM SANGER
KYSE-70 Growth inhibition assay Inhibition of human KYSE-70 cell growth in a cell viability assay. IC50=30.5114 μM SANGER
HUTU-80 Growth inhibition assay Inhibition of human HUTU-80 cell growth in a cell viability assay. IC50=41.0569 μM SANGER
L-363 Growth inhibition assay Inhibition of human L-363 cell growth in a cell viability assay. IC50=16.4577 μM SANGER
L-428 Growth inhibition assay Inhibition of human L-428 cell growth in a cell viability assay. IC50=24.5791 μM SANGER
LAMA-84 Growth inhibition assay Inhibition of human LAMA-84 cell growth in a cell viability assay. IC50=4.1702 μM SANGER
HuCCT1 Growth inhibition assay Inhibition of human HuCCT1 cell growth in a cell viability assay. IC50=10.6034 μM SANGER
LB1047-RCC Growth inhibition assay Inhibition of human LB1047-RCC cell growth in a cell viability assay. IC50=2.74888 μM SANGER
IGR-1 Growth inhibition assay Inhibition of human IGR-1 cell growth in a cell viability assay. IC50=28.8874 μM SANGER
LB2518-MEL Growth inhibition assay Inhibition of human LB2518-MEL cell growth in a cell viability assay. IC50=49.8723 μM SANGER
LB373-MEL-D Growth inhibition assay Inhibition of human LB373-MEL-D cell growth in a cell viability assay. IC50=7.76771 μM SANGER
LB771-HNC Growth inhibition assay Inhibition of human LB771-HNC cell growth in a cell viability assay. IC50=35.1658 μM SANGER
IST-SL1 Growth inhibition assay Inhibition of human IST-SL1 cell growth in a cell viability assay. IC50=26.6591 μM SANGER
LCLC-103H Growth inhibition assay Inhibition of human LCLC-103H cell growth in a cell viability assay. IC50=36.7803 μM SANGER
LC-2-ad Growth inhibition assay Inhibition of human LC-2-ad cell growth in a cell viability assay. IC50=21.2729 μM SANGER
LCLC-97TM1 Growth inhibition assay Inhibition of human LCLC-97TM1 cell growth in a cell viability assay. IC50=4.53686 μM SANGER
LN-405 Growth inhibition assay Inhibition of human LN-405 cell growth in a cell viability assay. IC50=22.5913 μM SANGER
LK-2 Growth inhibition assay Inhibition of human LK-2 cell growth in a cell viability assay. IC50=13.7639 μM SANGER
J-RT3-T3-5 Growth inhibition assay Inhibition of human J-RT3-T3-5 cell growth in a cell viability assay. IC50=6.869 μM SANGER
LS-1034 Growth inhibition assay Inhibition of human LS-1034 cell growth in a cell viability assay. IC50=6.20706 μM SANGER
LS-123 Growth inhibition assay Inhibition of human LS-123 cell growth in a cell viability assay. IC50=3.74284 μM SANGER
K5 Growth inhibition assay Inhibition of human K5 cell growth in a cell viability assay. IC50=1.58357 μM SANGER
LS-411N Growth inhibition assay Inhibition of human LS-411N cell growth in a cell viability assay. IC50=5.79441 μM SANGER
LU-134-A Growth inhibition assay Inhibition of human LU-134-A cell growth in a cell viability assay. IC50=21.1026 μM SANGER
KG-1 Growth inhibition assay Inhibition of human KG-1 cell growth in a cell viability assay. IC50=24.1928 μM SANGER
KINGS-1 Growth inhibition assay Inhibition of human KINGS-1 cell growth in a cell viability assay. IC50=5.60944 μM SANGER
LU-65 Growth inhibition assay Inhibition of human LU-65 cell growth in a cell viability assay. IC50=0.12633 μM SANGER
LU-139 Growth inhibition assay Inhibition of human LU-139 cell growth in a cell viability assay. IC50=0.3051 μM SANGER
LU-99A Growth inhibition assay Inhibition of human LU-99A cell growth in a cell viability assay. IC50=37.5731 μM SANGER
LXF-289 Growth inhibition assay Inhibition of human LXF-289 cell growth in a cell viability assay. IC50=2.63565 μM SANGER
M14 Growth inhibition assay Inhibition of human M14 cell growth in a cell viability assay. IC50=44.1332 μM SANGER
KNS-62 Growth inhibition assay Inhibition of human KNS-62 cell growth in a cell viability assay. IC50=3.94731 μM SANGER
LoVo Growth inhibition assay Inhibition of human LoVo cell growth in a cell viability assay. IC50=2.10797 μM SANGER
KOSC-2 Growth inhibition assay Inhibition of human KOSC-2 cell growth in a cell viability assay. IC50=3.83451 μM SANGER
MC-IXC Growth inhibition assay Inhibition of human MC-IXC cell growth in a cell viability assay. IC50=11.6728 μM SANGER
MC116 Growth inhibition assay Inhibition of human MC116 cell growth in a cell viability assay. IC50=3.95489 μM SANGER
MDA-MB-175-VII Growth inhibition assay Inhibition of human MDA-MB-175-VII cell growth in a cell viability assay. IC50=0.03416 μM SANGER
MCF7 Growth inhibition assay Inhibition of human MCF7 cell growth in a cell viability assay. IC50=16.4723 μM SANGER
MDA-MB-361 Growth inhibition assay Inhibition of human MDA-MB-361 cell growth in a cell viability assay. IC50=0.72662 μM SANGER
KS-1 Growth inhibition assay Inhibition of human KS-1 cell growth in a cell viability assay. IC50=4.50889 μM SANGER
MDA-MB-157 Growth inhibition assay Inhibition of human MDA-MB-157 cell growth in a cell viability assay. IC50=2.21828 μM SANGER
MDA-MB-453 Growth inhibition assay Inhibition of human MDA-MB-453 cell growth in a cell viability assay. IC50=11.9515 μM SANGER
KU812 Growth inhibition assay Inhibition of human KU812 cell growth in a cell viability assay. IC50=0.15456 μM SANGER
ME-180 Growth inhibition assay Inhibition of human ME-180 cell growth in a cell viability assay. IC50=1.61096 μM SANGER
MEG-01 Growth inhibition assay Inhibition of human MEG-01 cell growth in a cell viability assay. IC50=4.99403 μM SANGER
KYSE-410 Growth inhibition assay Inhibition of human KYSE-410 cell growth in a cell viability assay. IC50=1.65672 μM SANGER
MEL-HO Growth inhibition assay Inhibition of human MEL-HO cell growth in a cell viability assay. IC50=30.1423 μM SANGER
MFE-280 Growth inhibition assay Inhibition of human MFE-280 cell growth in a cell viability assay. IC50=16.0488 μM SANGER
MFH-ino Growth inhibition assay Inhibition of human MFH-ino cell growth in a cell viability assay. IC50=37.3371 μM SANGER
KYSE-510 Growth inhibition assay Inhibition of human KYSE-510 cell growth in a cell viability assay. IC50=19.8748 μM SANGER
MFM-223 Growth inhibition assay Inhibition of human MFM-223 cell growth in a cell viability assay. IC50=16.3965 μM SANGER
MG-63 Growth inhibition assay Inhibition of human MG-63 cell growth in a cell viability assay. IC50=5.48762 μM SANGER
MHH-NB-11 Growth inhibition assay Inhibition of human MHH-NB-11 cell growth in a cell viability assay. IC50=16.0839 μM SANGER
LAN-6 Growth inhibition assay Inhibition of human LAN-6 cell growth in a cell viability assay. IC50=40.0112 μM SANGER
MKN1 Growth inhibition assay Inhibition of human MKN1 cell growth in a cell viability assay. IC50=3.47108 μM SANGER
MIA-PaCa-2 Growth inhibition assay Inhibition of human MIA-PaCa-2 cell growth in a cell viability assay. IC50=28.7959 μM SANGER
MKN28 Growth inhibition assay Inhibition of human MKN28 cell growth in a cell viability assay. IC50=32.7838 μM SANGER
ML-2 Growth inhibition assay Inhibition of human ML-2 cell growth in a cell viability assay. IC50=0.24802 μM SANGER
MKN45 Growth inhibition assay Inhibition of human MKN45 cell growth in a cell viability assay. IC50=21.1551 μM SANGER
MMAC-SF Growth inhibition assay Inhibition of human MMAC-SF cell growth in a cell viability assay. IC50=19.2607 μM SANGER
MKN7 Growth inhibition assay Inhibition of human MKN7 cell growth in a cell viability assay. IC50=2.35335 μM SANGER
LB2241-RCC Growth inhibition assay Inhibition of human LB2241-RCC cell growth in a cell viability assay. IC50=0.10884 μM SANGER
LB831-BLC Growth inhibition assay Inhibition of human LB831-BLC cell growth in a cell viability assay. IC50=38.6039 μM SANGER
MOLT-13 Growth inhibition assay Inhibition of human MOLT-13 cell growth in a cell viability assay. IC50=0.23975 μM SANGER
MSTO-211H Growth inhibition assay Inhibition of human MSTO-211H cell growth in a cell viability assay. IC50=45.9482 μM SANGER
MOLT-16 Growth inhibition assay Inhibition of human MOLT-16 cell growth in a cell viability assay. IC50=17.8935 μM SANGER
MOLT-4 Growth inhibition assay Inhibition of human MOLT-4 cell growth in a cell viability assay. IC50=7.02135 μM SANGER
MZ1-PC Growth inhibition assay Inhibition of human MZ1-PC cell growth in a cell viability assay. IC50=30.393 μM SANGER
MZ2-MEL Growth inhibition assay Inhibition of human MZ2-MEL cell growth in a cell viability assay. IC50=16.8403 μM SANGER
MPP-89 Growth inhibition assay Inhibition of human MPP-89 cell growth in a cell viability assay. IC50=22.8661 μM SANGER
MZ7-mel Growth inhibition assay Inhibition of human MZ7-mel cell growth in a cell viability assay. IC50=34.6487 μM SANGER
LNCaP-Clone-FGC Growth inhibition assay Inhibition of human LNCaP-Clone-FGC cell growth in a cell viability assay. IC50=15.4248 μM SANGER
Mewo Growth inhibition assay Inhibition of human Mewo cell growth in a cell viability assay. IC50=34.1349 μM SANGER
LOXIMVI Growth inhibition assay Inhibition of human LOXIMVI cell growth in a cell viability assay. IC50=5.63873 μM SANGER
NB12 Growth inhibition assay Inhibition of human NB12 cell growth in a cell viability assay. IC50=25.2947 μM SANGER
NB10 Growth inhibition assay Inhibition of human NB10 cell growth in a cell viability assay. IC50=22.2371 μM SANGER
NB13 Growth inhibition assay Inhibition of human NB13 cell growth in a cell viability assay. IC50=42.6217 μM SANGER
NB5 Growth inhibition assay Inhibition of human NB5 cell growth in a cell viability assay. IC50=1.41317 μM SANGER
NB14 Growth inhibition assay Inhibition of human NB14 cell growth in a cell viability assay. IC50=6.43836 μM SANGER
LS-513 Growth inhibition assay Inhibition of human LS-513 cell growth in a cell viability assay. IC50=4.31217 μM SANGER
NB17 Growth inhibition assay Inhibition of human NB17 cell growth in a cell viability assay. IC50=31.5185 μM SANGER
NB69 Growth inhibition assay Inhibition of human NB69 cell growth in a cell viability assay. IC50=1.02945 μM SANGER
NCI-H1048 Growth inhibition assay Inhibition of human NCI-H1048 cell growth in a cell viability assay. IC50=2.49158 μM SANGER
NBsusSR Growth inhibition assay Inhibition of human NBsusSR cell growth in a cell viability assay. IC50=3.18254 μM SANGER
LU-135 Growth inhibition assay Inhibition of human LU-135 cell growth in a cell viability assay. IC50=33.8829 μM SANGER
NCI-H1092 Growth inhibition assay Inhibition of human NCI-H1092 cell growth in a cell viability assay. IC50=16.8316 μM SANGER
NCI-H1155 Growth inhibition assay Inhibition of human NCI-H1155 cell growth in a cell viability assay. IC50=19.7238 μM SANGER
NCI-H1304 Growth inhibition assay Inhibition of human NCI-H1304 cell growth in a cell viability assay. IC50=26.9108 μM SANGER
NCI-H1395 Growth inhibition assay Inhibition of human NCI-H1395 cell growth in a cell viability assay. IC50=20.6697 μM SANGER
NCI-H1437 Growth inhibition assay Inhibition of human NCI-H1437 cell growth in a cell viability assay. IC50=18.1641 μM SANGER
MDA-MB-231 Growth inhibition assay Inhibition of human MDA-MB-231 cell growth in a cell viability assay. IC50=28.2795 μM SANGER
MDA-MB-415 Growth inhibition assay Inhibition of human MDA-MB-415 cell growth in a cell viability assay. IC50=23.9498 μM SANGER
MHH-ES-1 Growth inhibition assay Inhibition of human MHH-ES-1 cell growth in a cell viability assay. IC50=27.4447 μM SANGER
MHH-PREB-1 Growth inhibition assay Inhibition of human MHH-PREB-1 cell growth in a cell viability assay. IC50=10.1999 μM SANGER
MLMA Growth inhibition assay Inhibition of human MLMA cell growth in a cell viability assay. IC50=22.747 μM SANGER
MN-60 Growth inhibition assay Inhibition of human MN-60 cell growth in a cell viability assay. IC50=7.28089 μM SANGER
MS-1 Growth inhibition assay Inhibition of human MS-1 cell growth in a cell viability assay. IC50=30.8889 μM SANGER
MV-4-11 Growth inhibition assay Inhibition of human MV-4-11 cell growth in a cell viability assay. IC50=3.87994 μM SANGER
Mo-T Growth inhibition assay Inhibition of human Mo-T cell growth in a cell viability assay. IC50=18.8204 μM SANGER
NB7 Growth inhibition assay Inhibition of human NB7 cell growth in a cell viability assay. IC50=2.29676 μM SANGER
NCI-H1299 Growth inhibition assay Inhibition of human NCI-H1299 cell growth in a cell viability assay. IC50=6.63171 μM SANGER
NCI-H1355 Growth inhibition assay Inhibition of human NCI-H1355 cell growth in a cell viability assay. IC50=34.3889 μM SANGER
NCI-H1792 Growth inhibition assay Inhibition of human NCI-H1792 cell growth in a cell viability assay. IC50=50.2744 μM SANGER
NCI-H2347 Growth inhibition assay Inhibition of human NCI-H2347 cell growth in a cell viability assay. IC50=58.3648 μM SANGER
NCI-H2452 Growth inhibition assay Inhibition of human NCI-H2452 cell growth in a cell viability assay. IC50=56.5819 μM SANGER
PSN1 Growth inhibition assay Inhibition of human PSN1 cell growth in a cell viability assay. IC50=50.9394 μM SANGER
RH-1 Growth inhibition assay Inhibition of human RH-1 cell growth in a cell viability assay. IC50=66.3277 μM SANGER
SK-LMS-1 Growth inhibition assay Inhibition of human SK-LMS-1 cell growth in a cell viability assay. IC50=51.9815 μM SANGER
SK-MEL-30 Growth inhibition assay Inhibition of human SK-MEL-30 cell growth in a cell viability assay. IC50=133.481 μM SANGER
SNB75 Growth inhibition assay Inhibition of human SNB75 cell growth in a cell viability assay. IC50=50.414 μM SANGER
SNU-423 Growth inhibition assay Inhibition of human SNU-423 cell growth in a cell viability assay. IC50=70.6017 μM SANGER
SW1088 Growth inhibition assay Inhibition of human SW1088 cell growth in a cell viability assay. IC50=50.0201 μM SANGER
SW1783 Growth inhibition assay Inhibition of human SW1783 cell growth in a cell viability assay. IC50=52.4982 μM SANGER
SBC-5 Growth inhibition assay Inhibition of human SBC-5 cell growth in a cell viability assay. IC50=51.1085 μM SANGER
A375 Growth inhibition assay Inhibition of human A375 cell growth in a cell viability assay. IC50=53.6768 μM SANGER
AM-38 Growth inhibition assay Inhibition of human AM-38 cell growth in a cell viability assay. IC50=52.9492 μM SANGER
YH-13 Growth inhibition assay Inhibition of human YH-13 cell growth in a cell viability assay. IC50=60.0468 μM SANGER
TYK-nu Growth inhibition assay Inhibition of human TYK-nu cell growth in a cell viability assay. IC50=76.6063 μM SANGER
COLO-668 Growth inhibition assay Inhibition of human COLO-668 cell growth in a cell viability assay. IC50=60.5077 μM SANGER
ES6 Growth inhibition assay Inhibition of human ES6 cell growth in a cell viability assay. IC50=57.7541 μM SANGER
D-247MG Growth inhibition assay Inhibition of human D-247MG cell growth in a cell viability assay. IC50=59.5888 μM SANGER
H4 Growth inhibition assay Inhibition of human H4 cell growth in a cell viability assay. IC50=60.5614 μM SANGER
HMV-II Growth inhibition assay Inhibition of human HMV-II cell growth in a cell viability assay. IC50=157.194 μM SANGER
HT-1080 Growth inhibition assay Inhibition of human HT-1080 cell growth in a cell viability assay. IC50=62.203 μM SANGER
IA-LM Growth inhibition assay Inhibition of human IA-LM cell growth in a cell viability assay. IC50=54.091 μM SANGER
K-562 Growth inhibition assay Inhibition of human K-562 cell growth in a cell viability assay. IC50=50.5633 μM SANGER
MEL-JUSO Growth inhibition assay Inhibition of human MEL-JUSO cell growth in a cell viability assay. IC50=56.1737 μM SANGER
M059J Growth inhibition assay Inhibition of human M059J cell growth in a cell viability assay. IC50=51.0252 μM SANGER
NB6 Growth inhibition assay Inhibition of human NB6 cell growth in a cell viability assay. IC50=71.0797 μM SANGER
他の多くの細胞株試験データをご覧になる場合はこちらをクリックして下さい

生物活性

製品説明 Afatinib Dimaleate irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM, respectively; 100-fold more active against Gefitinib-resistant L858R-T790M EGFR mutant. Afatinib (BIBW2992) Dimaleate induces autophagy.
Targets
EGFR (L858R) [1]
(Cell-free assay)		 EGFR (wt) [1]
(Cell-free assay)		 EGFR (L858R/T790M) [1]
(Cell-free assay)		 HER2 [1]
(Cell-free assay)
0.4 nM 0.5 nM 10 nM 14 nM
In Vitro
In vitro BIBW2992 is more effective than erlotinib, gefitinib, or lapatinib in inhibiting survival of lung cancer cell lines harboring wild-type (H1666) or L858R/T790M (NCI-H1975) EGFR. BIBW2992 is similarly effective against NSCLC lines expressing HER2 776insV (NCI-H1781) or EGFR E746_A750del (HCC827), but shows no activity toward A549 cells, which express wild-type EGFR and HER2.[1] Afatinib enhances cytotoxicity of topotecan and mitoxantrone to SP cells, and increases the apoptosis induced by topotecan and mitoxantrone in SP cells.[2]
Kinase Assay In vitro kinase activity assay
EGFR kinase: Each 100 µL enzyme reaction contained 10 μL of inhibitor in 50% Me2SO, 20 μL of substrate solution (200 mM HEPES pH 7.4, 50 mM Mg-acetate, 2.5 mg/mL poly (EY), 5 μg/mL bio-pEY) and 20 µL enzyme preparation. The enzymatic reaction is started by addition of 50 µL of a 100 µM ATP solution made in 10 mM MgCl2. Assays are carried out at room temperature for 30 min and terminated by the addition of 50 µL of stop solution (250 mM EDTA in 20 mM HEPES pH 7.4). 100 µL are transferred to a streptavidin coated microtiterplate, after an incubation time of 60 min at room temperature the plate is washed with 200 µL of wash solution (50 mM Tris, 0.05% Tween20). A 100 µL aliquot of a HRPO- labeled anti-PY antibody (PY20H Anti-Ptyr:HRP ) 250 ng/mL are added to the wells. After 60 min of incubation, the plate is washed three times with a 200 µL wash solution. The samples are then developed with a 100µL TMB Peroxidase Solution (A:B= 1:1). The reaction is stopped after 10 min. The plate is transferred to an ELISA reader and extinction is measured at OD450nm. HER2-IC enzyme: Enzyme activity is assayed in the presence or absence of serial inhibitor dilutions performed in 50 % Me2SO. Each 100 µL reaction contains similar components as described for EGFR kinase assay with addition of 1000 µM Na3VO4. The enzymatic reaction is started by addition of 50µL of 500 µM ATP solution made in 10 mM Mg-acetate. The dilution of the enzyme is set so that incorporation of phosphate into bio-pEY is linear with respect to time and amount of enzyme. The enzyme preparation is diluted in 20 mM HEPES pH 7.4, 130 mM NaCl, 0.05% Triton X-100, 1 mM DTT and 10% glycerol. Assays are carried out at room temperature for 30 min and terminated by the addition of 50 µL of stop solution. Src kinase assays: Each 100 µL reaction contained 10 µL of inhibitor in 50 % Me2SO, 20µL of enzyme preparation, 20 µL of substrate solution supplemented with 1000 µM Na3VO4. The enzymatic reaction is started by addition of 50 µL of a 1000 µM ATP solution made in 10 mM Mg-acetate. BIRK kinase assay: 250 mM Tris pH 7.4, 10mM DTT, 2.5 mg/mL poly(EY), 5 mg/mL bio-pEY is used as substrate solution and enzymatic reaction is started by addition of 50 µL of a 2 mM ATP solution made in 8 mM MnCl2, 20 mM Mg-acetate. VEGF2 and HGFR kinase assays: Assays are carried out at room temperature for 20 minutes and terminated by the addition of 10 µL of 5 % H3PO4. The precipitate is then trapped onto GF/B filters using a 96 well filter mate universal harvester. After extensive washing the filter plate is dried for 1 h at 50°C, sealed and incorporated radioactivity is determined by scintillation counting using a TopCount™ or a Microbeta b counter™.
細胞実験 細胞株 SP and NSP cell lines
濃度 1 μM
反応時間 48 h
実験の流れ Cytotoxicity is determined using MTT assay. The IC 50 value is defined as the drug concentration resulting in 50% cell death. Both the fitted sigmoidal dose response curve and IC50 are calculated by Bliss method.
実験結果図 Methods Biomarkers 結果図 PMID
Growth inhibition assay Cell apoptosis Cell viability 25537503
Western blot CIP2A / p-AKT / AKT / PARP p-EGFR / p-IGF1R / p-ERK / p-AKT 25537503
Immunofluorescence p65 vacuoles 26317651
In Vivo
In Vivo In the MDA-MB-453 xenograft model, BIBW2992 (20 mg/kg, p.o.) results in dramatic tumor regression with a cumulative treated/control tumor volume ratio (T/C ratio) of 2%, and downregulation of EGFR and AKT phosphorylation.[1] In A7, A431, FaDu, UT-SCC-14 and UT-SCC-15 xenograft models, application of BIBW 2992 (30 mg/kg, p.o.) leads to a significant prolongation of tumour growth time.[3] In HER2-amplified xenograft medel, Afatinib (30 mg/kg, p.o.) results a markedly inhibition in tumor growth and a significant improvement in the duration of overall survival.[4] In HER2-positive gastric cancer NCI-N87 xenograft, afatinib (25 mg/kg, p.o.) leads to dramatic tumor volume regression within 4 d and near-complete tumor resolution after 21 d of treatment.[5]
動物実験 動物モデル SCID mice harbouring ARK2 xenografts
投与量 25 mg/kg
投与経路 p.o.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06302621 Recruiting
Advanced Solid Tumor|Unresectable Solid Tumor|Metastatic Solid Tumor|Cholangiocarcinoma
Massachusetts General Hospital|Boehringer Ingelheim|Incyte Corporation
 July 1 2024 Phase 1
NCT05298176 Recruiting
Non-Small Cell Lung Cancer
Amsterdam UMC location VUmc
 January 4 2022 Phase 2
NCT04795245 Completed
Non-squamous Non-Small Cell Lung Cancer
Boehringer Ingelheim
 August 26 2021 --
NCT04497584 Recruiting
Advanced Squamous Non Small Cell Lung Cancer
University of Texas Southwestern Medical Center
 August 4 2021 Phase 2
NCT04413201 Active not recruiting
Non-squamous NSCLC
Michael Hopp|Boehringer Ingelheim|Johannes Gutenberg University Mainz
 September 11 2020 Phase 4

化学情報

分子量 717.18 化学式

C24H25ClFN5O3.2C4H4O4
CAS No. 850140-73-7 SDF Download Afatinib Dimaleate SDFをダウンロードする
Smiles CN(C)CC=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC4CCOC4.C(=CC(=O)O)C(=O)O.C(=CC(=O)O)C(=O)O
保管

In vitro
Batch:

DMSO : 100 mg/mL ( (139.43 mM)； 吸湿したDMSOは溶解度を減少させます。新しいDMSOをご使用ください。)

Water : Insoluble

Ethanol : Insoluble

モル濃度計算器

in vivo
Batch:

Add solvents to the product individually and in order.

投与溶液組成計算機

実験計算

モル濃度計算器

質量 濃度 体積 分子量

投与溶液組成計算機(クリア溶液)

ステップ１：実験データを入力してください。（実験操作によるロスを考慮し、動物数を1匹分多くして計算・調製することを推奨します）

mg/kg g μL 匹

ステップ２：投与溶媒の組成を入力してください。（ロット毎に適した溶解組成が異なる場合があります。詳細については弊社までお問い合わせください）

% DMSO % % Tween 80 % ddH2O
%DMSO %

計算結果：

投与溶媒濃度： mg/ml;

DMSOストック溶液調製方法： mg 試薬を μL DMSOに溶解する（濃度 mg/mL, 注：濃度が当該ロットのDMSO溶解度を超える場合はご連絡ください。 )

投与溶媒調製方法：Take μL DMSOストック溶液に μL PEG300，を加え、完全溶解後μL Tween 80，を加えて完全溶解させた後 μL ddH2O，を加え完全に溶解させます。

投与溶媒調製方法：μL DMSOストック溶液に μL Corn oil，を加え、完全溶解。

注意：１.ストック溶液に沈殿、混濁などがないことをご確認ください；
２.順番通りに溶剤を加えてください。次のステップに進む前に溶液に沈殿、混濁などがないことを確認してから加えてください。ボルテックス、ソニケーション、水浴加熱など物理的な方法で溶解を早めることは可能です。

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Tags: Afatinib Dimaleateを買う | Afatinib Dimaleate ic50 | Afatinib Dimaleate供給者 | Afatinib Dimaleateを購入する | Afatinib Dimaleate費用 | Afatinib Dimaleate生産者 | オーダーAfatinib Dimaleate | Afatinib Dimaleate化学構造 | Afatinib Dimaleate分子量 | Afatinib Dimaleate代理店