EGFR/ErbB1
HER2/ErbB2
ErbB3
ErbB4
mutant EGFR

ErbB3 阻害剤

製品コード	製品名	製品説明	Selective / Pan	IC50 / Ki
S2192	Sapitinib (AZD8931)	Sapitinib (AZD8931) is a reversible, ATP competitive inhibitor of EGFR, ErbB2 and ErbB3 with IC50 of 4 nM, 3 nM and 4 nM in cell-free assays, more potent than Gefitinib or Lapatinib against NSCLC cell, 100-fold more selective for the ErbB family than MNK1 and Flt. Phase 2.	Pan	ErbB3, IC50: 4 nM