ホームページ Endocrinology & Hormones -Neuronal Signaling -GPCR & G Protein Adrenergic Receptor β-adrenergic receptor 選択性 阻害剤 | 作動薬 | 拮抗剤
  • α-adrenergic receptor
  • β-adrenergic receptor
  • Beta-Adrenergic Receptor

β-adrenergic receptor 選択性 阻害剤 | 作動薬 | 拮抗剤

製品コード 製品名 製品説明 Selective / Pan IC50 / Ki
S5267 Nylidrin Hydrochloride Nylidrin Hydrochloride (Buphenine), a β-adrenergic agonist, is used therapeutically for its vasodilating effect on the peripheral circulation and possibly on the cerebral circulation as well. Selective
S3294 Demethyl-Coclaurine Demethyl-Coclaurine (Higenamine, Norcoclaurine), the key component of the Chinese herb aconite root, is a beta-2 adrenergic receptor (β2-AR) agonist. Demethyl-Coclaurine stimulates AKT phosphorylation and requires PI3K activation for the anti-apoptotic effect in cardiomyocytes. Selective
S3727 Vilanterol Trifenate Vilanterol trifenatate (GW642444M) is a novel inhaled long-acting beta2 adrenoceptor agonist with inherent 24-hour activity for once daily treatment of COPD and asthma. Selective
S5430 Metoprolol Metoprolol is a cardioselective β1-adrenergic blocking agent with log Kd values of −7.26±0.07, −6.89±0.09, −5.16±0.12 for β1, β2, and β3 adrenoceptors, respectively. It is used for acute myocardial infarction, heart failure, angina pectoris and mild to moderate hypertension. Selective
S5769 Fenoterol Fenoterol (Phenoterol) is a β2 adrenoreceptor agonist with bronchodilator activity. Selective
S5540 Landiolol hydrochloride Landiolol hydrochloride (ONO-1101) is the hydrochloride salt form of Landiolol, which is an ultra-short-acting β1 selective adrenoceptor antagonist. Selective
S5341 Metroprolol succinate Metroprolol Succinate (Metoprolol succinate) is the succinate salt form of metoprolol, a cardioselective competitive beta-1 adrenergic receptor antagonist with antihypertensive properties and devoid of intrinsic sympathomimetic activity. Selective
S5023 Nadolol Nadolol (Corgard, Solgol, Anabet, SQ11725) is a non-selective beta-adrenergic antagonist with antihypertensive and antiarrhythmic activities. Selective
S4485 Olodaterol (BI 1744) Olodaterol (BI 1744) is a long-acting β2-adrenergic receptor agonist that is used as a component of an inhalation (Tiotropium/Olodaterol) for treating patients with chronic obstructive pulmonary disease (COPD). Selective
S5768 Fenoterol hydrobromide Fenoterol hydrobromide (Phenoterol) is the the hydrobromide salt of fenoterol, a β2 adrenoreceptor agonist with bronchodilator activity. Selective
S5494 Salbutamol Salbutamol (Albuterol) is a short-acting, selective beta2-adrenergic receptor agonist used to treat or prevent bronchospasm in patients with asthma, bronchitis, emphysema, and other lung diseases. Selective
S7974 L755507 L-755,507 is characterized as a potent and selective β3 adrenergic receptor partial agonist with EC50 of 0.43 nM. It is also recently identified to enhance CRISPR-mediated homology-directed repair (HDR) efficiency in human induced pluripotent stem cells (iPSCs) and other cell types. Selective β3 adrenergic receptor, EC50: 0.43 nM
S8114 Zenidolol (ICI-118551) Hydrochloride Zenidolol (ICI-118551) Hydrochloride is a highly selective β2-adrenergic receptor antagonist with Ki values of 0.7, 49.5 and 611 nM for β2, β1 and β3 receptors, respectively. Selective β2-adrenergic receptor, Ki: 0.7nM; β1-adrenergic receptor, Ki: 49.5nM; β3-adrenoceptor, Ki: 611nM
S4085 Levobetaxolol HCl Levobetaxolol (AL 1577A,(S)-Betaxolol hydrochloride) exhibits a higher affinity at cloned human β1 and β2 receptors with Ki value of 0.76 nM and 32.6 nM, respectively. Selective β1-adrenergic receptor, Ki: 0.76 nM; β2-adrenergic receptor, Ki: 32.6 nM
S1549 Nebivolol hydrochloride (R-65824) Nebivolol HCl (R-65824) selectively inhibits β1-adrenoceptor with IC50 of 0.8 nM. Selective β1-adrenoceptor, IC50: 0.8 nM
S5527 Salmeterol Salmeterol (Astmerole, GR-33343X, SN408D) is a long-acting beta2-adrenergic receptor agonist with Ki value of 1.5 nM for WT β2AR and shows very high selectivity for the WT β2AR(β1Ki/β2Ki ratio of approximately 1500). Selective β2-adrenergic receptor, Ki: 1.5 nM
S4123 Timolol Maleate Timolol Maleate (MK-950,(S)-Timolol Maleate) is a non-selective, beta-adrenergic receptor antagonist for β1/β2 with Ki of 1.97 nM/2.0 nM. Selective β1-adrenergic receptor, Ki: 1.97 nM; β2-adrenergic receptor, Ki: 2.0 nM
S0032 Batefenterol  Batefenterol (GSK961081, TD-5959) is both a muscarinic receptor antagonist and a β2-adrenoceptor agonist with Ki of 1.4 nM, 1.3 nM and 3.7 nM for hM2, hM3 muscarinic receptors and hβ2-adrenoceptor, respectively. Selective hβ2-adrenoceptor, Ki: 3.7 nM
S4076 Propranolol HCl Propranolol HCl (AY-64043, ICI-45520, NCS-91523) is a competitive non-selective beta-adrenergic receptors inhibitor. Selective β-adrenergic receptor, IC50: 12 nM
S4009 Mirabegron Mirabegron (YM 178) is a selective β3-adrenoceptor agonist with EC50 of 22.4 nM. Selective β3-adrenoceptor, EC50: 22.4 nM
S0812 SR59230A SR59230A is a blood-brain barrier penetrating, potent and selective antagonist of β3-adrenergic receptor with IC50 of 40 nM, 408 nM, and 648 nM for β3, β1, and β2 receptors, respectively. Selective β3-adrenergic receptor, IC50: 40 nM; β1-adrenergic receptor, IC50: 408 nM; β2-adrenergic receptor, IC50: 648 nM
S3083 Indacaterol Maleate Indacaterol (QAB149) is an ultra-long-acting β-adrenoceptor agonist with pKi of 7.36 for β1-adrenoceptor and pKi of 5.48 for β2-adrenoceptor. Selective β1-adrenoceptor, pKi: 7.36; β2-adrenoceptor, pKi: 5.48
S5654 Indacaterol Indacaterol is an ultra-long-acting β-adrenoceptor agonist with pKi of 7.36 for β1-adrenoceptor and pKi of 5.48 for β2-adrenoceptor. Selective β1-adrenoceptor, pKi: 7.36; β2-adrenoceptor, pKi: 5.48
S4127 Terbutaline Sulfate Terbutaline Sulfate(Terbutaline hemisulfate) is a selective β2-adrenergic receptor agonist with IC50 of 53 nM. Selective β2-adrenergic receptor, IC50: 53 nM
S5778 Esmolol Esmolol is a cardioselective beta1 receptor blocker with rapid onset, a very short duration of action, and no significant intrinsic sympathomimetic or membrane stabilising activity at therapeutic dosages. Selective Human β1-Receptor, Ki: 194 nM; Human β2-Receptor, Ki: 5.8 μM
S4817 Atenolol Atenolol (Tenormin, Normiten, Blokium) is a selective β1 receptor antagonist with log Kd values of −6.66±0.05, −5.99±0.14, −4.11±0.07 for binding to the human β1-, β2- and β3-adrenoceptors. Selective β1 receptor, Kd: 0.25 μM; β2 receptor, Kd: 1 μM
S1827 Betaxolol HCl Betaxolol (SL 75212) is a β1 adrenergic receptor blocker with IC50 of 6 μM. Selective β1-adrenergic receptor, IC50: 6 μM
S2507 Salbutamol Sulfate Salbutamol Sulfate (Albuterol, Ventolin, Aerolin, Ventorlin, Asthalin, Asthavent) is a short-acting β2-adrenergic receptor agonist with an IC50 of 8.93 µM. Selective β2-adrenergic receptor, IC50: 8930 nM
S5925 Olodaterol hydrochloride Olodaterol hydrochloride (BI-1744) is the hydrochloride salt form of Olodaterol, which is a long-acting beta2-adrenergic agonist. Selective
S4010 Acebutolol HCl Acebutolol is a β-adrenergic receptors antagonist used in the treatment of hypertension, angina pectoris and cardiac arrhythmias. Selective
S4278 Carteolol HCl Carteolol HCl(Carteolol hydrochloride,OPC-1085 hydrochloride) is a β-adrenoceptor antagonist, used for the treatment of glaucoma. Selective
S1856 Metoprolol Tartrate Metoprolol Tartrate (CGP 2175E) is a selective β1 receptor blocker medication, used to treat hypertension and heart failure. Selective
S5789 Propafenone Propafenone (SA-79) is an orally active sodium channel blocking agent and a beta-adrenoceptor (β-adrenergic receptor) antagonist. Propafenone offers a broad spectrum of activity in the treatment of cardiac arrhythmias. Selective
S4135 Clorprenaline HCl Clorprenaline HCl (NSC 334693) is a β2-receptor agonist, it has a significant expansion of the bronchial effect. Selective
S2566 Isoprenaline (NCI-C55630) HCl Isoprenaline HCl (NCI-c55630,Isoproterenol hydrochloride) is a non-selective beta-adrenergic receptor agonist, used for the treatment of bradycardia and heart block. Selective
S1206 Bisoprolol fumarate Bisoprolol fumarate (EMD33512) is a selective type β1 adrenergic receptor blocker. Selective
S2533 Ritodrine HCl Ritodrine HCl (NSC 291565,DU 21220, Ritodrine) is a hydrochloride salt of ritodrine which is a β-2 adrenergic receptor agonist. Selective
S4277 Bambuterol HCl Bambuterol HCl(Bambuterol hydrochloride,KWD-2183 hydrochloride) is a potent β-adrenoceptor agonist, used in the treatment of asthma. Selective
S4296 Salmeterol Xinafoate Salmeterol Xinafoate(GR 33343X xinafoate,Salmetedur) is a long-acting β2-adrenergic receptor agonist with anti-inflammatory effects, used in the treatment of asthma symptoms and chronic obstructive pulmonary disease (COPD) symptoms. Selective
S2509 Sotalol HCl Sotalol(MJ-1999) is a non-selective beta blocker and a potassium channel blocker with an IC50 of 43 μM. Selective
S2091 Betaxolol Betaxolol (SL 75212,Dextrobetaxolol) is a selective beta1 adrenergic receptor blocker used in the treatment of hypertension and glaucoma. Selective
S2020 Formoterol Hemifumarate Formoterol Hemifumarate (Eformoterol, CGP 25827A, NSC 299587, YM 08316,Formoterol fumarate) is a potent, selective and long-acting β2-adrenoceptor agonist used in the management of asthma and chronic obstructive pulmonary disease(COPD). Selective
S3960 Higenamine hydrochloride Higenamine (Norcoclaurine, (+-)-Demethylcoclaurine), also known as Norcoclaurine HCl, is a non-selective β2 adrenoceptor agonist which is a chemical compound naturally occurring in a number of plants. Pan
S9470 Penbutolol Sulfate Penbutolol sulfate ((-)-Terbuclomine) is an effective beta-adrenergic receptor blocker and diuretic that is used as an antihypertensive agent. Pan
S9507 (−)-Norepinephrine (−)-Norepinephrine (Arterenol, Levarterenol, L-Noradrenaline) is a natural neurotransmitter and hormone. It is an agonist of adrenergic receptors with Ki values of 330, 56, and 740 nM for α1, α2, and β1 adrenoceptors, respectively. Pan β1 adrenoceptor, Ki: 740 nM
S2691 BMY 7378 Dihydrochloride BMY 7378 is a multi-targeted inhibitor of α2C-adrenoceptor and α1D-adrenoceptor with pKi of 6.54 and 8.2, respectively, and acts as a mixed agonist and antagonist for 5-HT1A receptor with pKi of 8.3. Pan β1-adrenoceptor, pIC50: 5.1
S1831 Carvedilol Carvedilol (BM-14190, SKF 105517) is a non-selective beta blocker/alpha-1 blocker, used to treat congestive heart failure (CHF) and high blood pressure. Pan
S4100 Esmolol HCl Esmolol (ASL8052) is a cardioselective b-blocker, used to control rapid heartbeats or abnormal heart rhythms. Pan
S4291 Labetalol HCl Labetalol HCl(AH-5158 hydrochloride,Labetalol hydrochloride,Sch-15719W) is a dual antagonist for both selective alpha1-adrenergic and nonselective beta-adrenergic receptors, used in the treatment of high blood pressure. Pan
S2521 Epinephrine bitartrate Epinephrine bitartrate (Adrenalinium) is an alpha- and beta-adrenergic receptor stimulator. Pan