SR786 |
Growth Inhibition Assay |
10 μM |
72 h |
does not induce apoptosis |
22801959 |
Myla |
Growth Inhibition Assay |
10 μM |
72 h |
does not induce apoptosis |
22801959 |
HH |
Growth Inhibition Assay |
10 μM |
72 h |
Induction of apoptosis slightly |
22801959 |
SP53 |
Growth Inhibition Assay |
0.1 μM |
72 h |
does not induce cell cycle arrest or apoptosis |
23676220 |
MINO |
Growth Inhibition Assay |
5 μM |
72 h |
does not induce cell cycle arrest or apoptosis |
23676220 |
MAVER-1 |
Growth Inhibition Assay |
5 μM |
72 h |
does not induce cell cycle arrest or apoptosis |
23676220 |
JEKO-1 |
Growth Inhibition Assay |
5 μM |
72 h |
does not induce cell cycle arrest or apoptosis |
23676220 |
JEKO-1 |
Growth Inhibition Assay |
10 μM |
72 h |
Inhibition of proliferation slightly |
23341541 |
Granta-519 |
Function Assay |
1 μM |
2 h |
Inhibition of Akt(s473) phosphorylation |
23341541 |
Granta-519 |
Function Assay |
1 μM |
2 h |
Inhibition of Akt(t308) phosphorylation |
23341541 |
JEKO-1 |
Function Assay |
1 μM |
72 h |
Inhibition of Akt phosphorylation in IgM-stimulated JEKO-1 |
23341541 |
Primary CLL cell |
Function Assay |
1 μM |
15 min |
Blocks BCR-induced LCP1 serine-5 activation |
24009233 |
Microglia |
Function Assay |
5 μM |
10 h |
Decrease of TNFa secretion from LPS-stimulated p110δD910A/D910A microglia |
24625684 |
Primary AML cell |
Growth Inhibition Assay |
1 μM |
3 h |
Suppression of rRNA synthesis |
25014775 |
Primary AML cell |
Function Assay |
1 μM |
3 h |
Inhibition of GSK3 phosphorylation |
25014775 |
Primary AML cell |
Function Assay |
1 μM |
3 h |
Inhibition of P70S6K phosphorylation |
25014775 |
Primary AML cell |
Function Assay |
1 μM |
3 h |
Inhibition of Akt phosphorylation |
25014775 |
K562 |
Growth Inhibition Assay |
1 μM |
72 h |
Inhibition of proliferation |
25014775 |
K562 |
Function Assay |
1 μM |
3 h |
Inhibition of GSK3 phosphorylation |
25014775 |
K562 |
Function Assay |
1 μM |
3 h |
Inhibition of P70S6K phosphorylation |
25014775 |
K562 |
Function Assay |
1 μM |
3 h |
Inhibition of Akt phosphorylation |
25014775 |
U266 |
Growth Inhibition Assay |
40 μM |
48 h |
79.5% inhibition rate |
25339332 |
HuT78 |
Growth Inhibition Assay |
10 μM |
72 h |
does not induce apoptosis |
22801959 |
MJ |
Growth Inhibition Assay |
10 μM |
72 h |
does not induce apoptosis |
22801959 |
DERL7 |
Growth Inhibition Assay |
10 μM |
72 h |
does not induce apoptosis |
22801959 |
L1236 |
Function Assay |
10 μM |
2 h |
Inhibition of Akt phosphorylation |
22210877 |
L428 |
Function Assay |
10 μM |
2 h |
Inhibition of Akt phosphorylation |
22210877 |
L591 |
Function Assay |
10 μM |
2 h |
Inhibition of Akt phosphorylation |
22210877 |
KMH-2 |
Function Assay |
10 μM |
2 h |
Inhibition of Akt phosphorylation |
22210877 |
L1236 |
Function Assay |
5 μM |
24 h |
Blocks secretion of the CCL5 |
22210877 |
L591 |
Function Assay |
5 μM |
24 h |
Blocks secretion of the CCL5 |
22210877 |
L1236 |
Apoptosis Assay |
5 μM |
24 h |
Induction of apoptosis |
22210877 |
L591 |
Apoptosis Assay |
5 μM |
24 h |
Induction of apoptosis |
22210877 |
U-87MG |
Function Assay |
100 nM |
24 h |
Inhibition of cell migration |
22079609 |
SW1783 |
Function Assay |
100 nM |
24 h |
Inhibition of cell migration |
22079609 |
U-87MG |
Function Assay |
5 μM |
24 h |
Inhibition of Akt phosphorylation substantially |
22079609 |
SW1783 |
Function Assay |
5 μM |
24 h |
Inhibition of Akt phosphorylation substantially |
22079609 |
U-373MG |
Function Assay |
5 μM |
24 h |
Inhibition of Akt phosphorylation substantially |
22079609 |
SK-MG3 |
Function Assay |
5 μM |
24 h |
Inhibition of Akt phosphorylation substantially |
22079609 |
SU-DHL-5 |
Function Assay |
1 μM |
24 h |
Induction of apoptosis |
20959606 |
WSU-NHL |
Function Assay |
1 μM |
24 h |
Induction of apoptosis |
20959606 |
CCRF-SB |
Function Assay |
1 μM |
24 h |
Induction of apoptosis |
20959606 |
INA-6 |
Function Assay |
5 μM |
6 h |
Inhibition of PI3K/Akt and ERK pathway |
20505158 |
LB |
Function Assay |
5 μM |
6 h |
Inhibition of PI4K/Akt and ERK pathway |
20505158 |
MOLM14 |
Antitumor assay |
100 mg/kg |
14 days |
Antitumor activity against human MOLM14 cells xenografted in nu/nu mouse assessed as tumor growth inhibition at 100 mg/kg, po administered daily via gavage dosed for 14 days and measured daily during compound dosing relative to control |
30053721 |
MOLM14 |
Antitumor assay |
100 mg/kg |
14 days |
Antitumor activity against human MOLM14 cells xenografted in nu/nu mouse assessed as induction of apoptosis at 100 mg/kg, po administered daily via gavage dosed for 14 days and measured daily during compound dosing by TUNEL based assay |
30053721 |
MOLM14 |
Antitumor assay |
100 mg/kg |
14 days |
Antitumor activity against human MOLM14 cells xenografted in nu/nu mouse assessed as inhibition of tumor proliferation 100 mg/kg, po administered daily via gavage dosed for 14 days and measured daily during compound dosing by Ki-67 labelling based immunoh |
30053721 |
MOLM14 |
Antiproliferative assay |
|
3 days |
Antiproliferative activity against human MOLM14 cells after 3 days by CellTiter-Glo assay, IC50 = 3.6 μM. |
27774127 |
MV4-11 |
Antiproliferative assay |
|
3 days |
Antiproliferative activity against human MV4-11 cells after 3 days by CellTiter-Glo assay, IC50 = 6.3 μM. |
27774127 |
Jurkat |
Antiproliferative assay |
|
3 days |
Antiproliferative activity against human Jurkat cells after 3 days by CellTiter-Glo assay, IC50 = 7.9 μM. |
27774127 |
Loucy |
Antiproliferative assay |
|
3 days |
Antiproliferative activity against human Loucy cells after 3 days by CellTiter-Glo assay, IC50 = 8.4 μM. |
27774127 |
MOLT4 |
Antiproliferative assay |
|
3 days |
Antiproliferative activity against human MOLT4 cells after 3 days by CellTiter-Glo assay, IC50 = 10.6 μM. |
27774127 |
SUDHL6 |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human SUDHL6 cells measured after 72 hrs by alamar blue assay, IC50 = 0.1176 μM. |
27846451 |
SU-DHL4 |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human SU-DHL4 cells measured after 72 hrs by alamar blue assay, IC50 = 1.6 μM. |
27846451 |
Pfeiffer |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human Pfeiffer cells measured after 72 hrs by alamar blue assay, IC50 = 6.8 μM. |
27846451 |
KARPAS422 |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human KARPAS422 cells measured after 72 hrs by alamar blue assay, IC50 = 8.1 μM. |
27846451 |
Sf21 |
Function assay |
|
30 mins |
Inhibition of N-terminal His6-tagged recombinant full-length human PI3K p110beta/untagged recombinant full length human p85alpha expressed in baculovirus infected Sf21 insect cells using PIP2/ATP as substrate after 30 mins by TR-FRET assay, IC50 = 3.7 μM. |
28106991 |
Sf21 |
Function assay |
|
30 mins |
Inhibition of N-terminal His6-tagged recombinant full-length human PI3K p110beta/untagged recombinant full length human p85alpha expressed in baculovirus infected Sf21 insect cells using PIP2/ATP as substrate after 30 mins by TR-FRET assay, IC50 = 3.7 μM. |
28106991 |
RPMI8266 |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human RPMI8266 cells after 72 hrs by MTT assay, IC50 = 0.00549 μM. |
28325601 |
Raji |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human Raji cells after 72 hrs by MTT assay, IC50 = 0.00995 μM. |
28325601 |
SUDHL6 |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human SUDHL6 cells after 72 hrs by CCK8 assay, IC50 = 0.65 μM. |
29534936 |
RPMI8226 |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human RPMI8226 cells after 72 hrs by MTT assay, IC50 = 5.49 μM. |
29534936 |
Raji |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human Raji cells after 72 hrs by MTT assay, IC50 = 9.95 μM. |
29534936 |
MOLM13 |
Growth inhibition assay |
|
72 hrs |
Growth inhibition of human MOLM13 cells after 72 hrs by CellTiter-Glo luminescent assay, GI50 = 1.7 μM. |
30053721 |
MOLM14 |
Growth inhibition assay |
|
72 hrs |
Growth inhibition of human MOLM14 cells after 72 hrs by CellTiter-Glo luminescent assay, GI50 = 6.4 μM. |
30053721 |
CLL PBMCs |
Growth Inhibition Assay |
|
|
IC50=2.9 nM |
25917267 |
MEC1 |
Growth Inhibition Assay |
|
|
IC50=20.4 μM |
25999352 |
B-cells |
Function assay |
|
|
Inhibition of PI3Kdelta in B-cells by proliferation assay, IC50 = 0.0061 μM. |
22924688 |
insect cells |
Function assay |
|
|
Inhibition of recombinant human full length His-tagged PI3Kgamma expressed in insect cells, IC50 = 0.089 μM. |
27846451 |
insect cells |
Function assay |
|
|
Inhibition of recombinant human full length His-tagged PI3Kbeta expressed in insect cells, IC50 = 0.565 μM. |
27846451 |
KARPAS422 |
Growth inhibition assay |
|
|
Growth inhibition of human KARPAS422 cells by CCK8 assay, GI50 = 0.68 μM. |
28835805 |
Pfeiffer |
Growth inhibition assay |
|
|
Growth inhibition of human Pfeiffer cells by CCK8 assay, GI50 = 0.74 μM. |
28835805 |
Saos-2 |
qHTS assay |
|
|
qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Saos-2 cells |
29435139 |
SK-N-SH |
qHTS assay |
|
|
qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-SH cells |
29435139 |
MG 63 (6-TG R) |
qHTS assay |
|
|
qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for MG 63 (6-TG R) cells |
29435139 |
NB1643 |
qHTS assay |
|
|
qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB1643 cells |
29435139 |
OHS-50 |
qHTS assay |
|
|
qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for OHS-50 cells |
29435139 |
Rh41 |
qHTS assay |
|
|
qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh41 cells |
29435139 |
SK-N-MC |
qHTS assay |
|
|
qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-MC cells |
29435139 |
NB-EBc1 |
qHTS assay |
|
|
qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB-EBc1 cells |
29435139 |
LAN-5 |
qHTS assay |
|
|
qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for LAN-5 cells |
29435139 |
SU-DHL6 |
Growth inhibition assay |
|
|
Growth inhibition of human SU-DHL6 cells by CellTiter-Glo assay, GI50 = 0.042 μM. |
29601991 |