ホームページ Cytoskeletal Signaling HSP (HSP90) inhibitor - IGF-1R inhibitor - Autophagy activator - Apoptosis related activator Luminespib (NVP-AUY922) For research use only.

Luminespib (NVP-AUY922)

別名：AUY-922, VER-52296

Luminespib (AUY-922, NVP-AUY922, VER-52296) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Luminespib (AUY-922, NVP-AUY922) effectively downregulates and destabilizes the IGF-1Rβ protein and results in growth inhibition, autophagy and apoptosis. Phase 2.

Luminespib (NVP-AUY922)化学構造

CAS No. 747412-49-3

サイズ 価格(税別) 在庫状況
10mM (1mL in DMSO) JPY 48000 国内在庫あり
JPY 24000 国内在庫あり
JPY 40500 国内在庫あり
JPY 70500 国内在庫あり
JPY 220500 国内在庫なし(納期7~10日)

代表番号: 045-509-1970|電子メール：[email protected]
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文献中Selleckの製品使用例（107）

製品安全説明書

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Luminespib (NVP-AUY922)関連製品

シグナル伝達経路

HSP (HSP90) Signaling Pathways

HSP (HSP90)シグナル伝達経路

HSP (HSP90)阻害剤の選択性比較

Cell Data

Cell Lines Assay Type Concentration Incubation Time 活性情報 PMID
J-RT3-T3-5 Growth Inhibition Assay IC50=0.08968 μM SANGER
EFO-21 Growth Inhibition Assay IC50=0.08991 μM SANGER
MDA-MB-231 Growth Inhibition Assay IC50=0.09082 μM SANGER
SAS Growth Inhibition Assay IC50=0.09215 μM SANGER
SBC-5 Growth Inhibition Assay IC50=0.09193 μM SANGER
SNU-387 Growth Inhibition Assay IC50=0.09218 μM SANGER
MHH-PREB-1 Growth Inhibition Assay IC50=0.0931 μM SANGER
EVSA-T Growth Inhibition Assay IC50=0.09265 μM SANGER
KARPAS-45 Growth Inhibition Assay IC50=0.09345 μM SANGER
SJRH30 Growth Inhibition Assay IC50=0.09444 μM SANGER
NB12 Growth Inhibition Assay IC50=0.09518 μM SANGER
JEG-3 Growth Inhibition Assay IC50=0.09505 μM SANGER
HCC1419 Growth Inhibition Assay IC50=0.09541 μM SANGER
HCC1599 Growth Inhibition Assay IC50=0.09601 μM SANGER
IPC-298 Growth Inhibition Assay IC50=0.09644 μM SANGER
MPP-89 Growth Inhibition Assay IC50=0.09721 μM SANGER
MDA-MB-468 Growth Inhibition Assay IC50=0.09985 μM SANGER
HT-1376 Growth Inhibition Assay IC50=0.09861 μM SANGER
HCC2218 Growth Inhibition Assay IC50=0.09999 μM SANGER
LK-2 Growth Inhibition Assay IC50=0.10176 μM SANGER
PFSK-1 Growth Inhibition Assay IC50=0.10267 μM SANGER
GR-ST Growth Inhibition Assay IC50=0.1021 μM SANGER
NCI-H2052 Growth Inhibition Assay IC50=0.10407 μM SANGER
A673 Growth Inhibition Assay IC50=0.10431 μM SANGER
23132-87 Growth Inhibition Assay IC50=0.10488 μM SANGER
EKVX Growth Inhibition Assay IC50=0.10483 μM SANGER
EW-18 Growth Inhibition Assay IC50=0.10604 μM SANGER
KU-19-19 Growth Inhibition Assay IC50=0.10817 μM SANGER
COLO-824 Growth Inhibition Assay IC50=0.1102 μM SANGER
NCI-H441 Growth Inhibition Assay IC50=0.10899 μM SANGER
SK-MM-2 Growth Inhibition Assay IC50=0.11145 μM SANGER
HCC1806 Growth Inhibition Assay IC50=0.11108 μM SANGER
DEL Growth Inhibition Assay IC50=0.11192 μM SANGER
NCI-H661 Growth Inhibition Assay IC50=0.11195 μM SANGER
BEN Growth Inhibition Assay IC50=0.11607 μM SANGER
LC4-1 Growth Inhibition Assay IC50=0.11466 μM SANGER
RPMI-8226 Growth Inhibition Assay IC50=0.11719 μM SANGER
AU565 Growth Inhibition Assay IC50=0.11831 μM SANGER
CAS-1 Growth Inhibition Assay IC50=0.11964 μM SANGER
UACC-62 Growth Inhibition Assay IC50=0.1212 μM SANGER
C-4-II Growth Inhibition Assay IC50=0.1217 μM SANGER
SK-MEL-2 Growth Inhibition Assay IC50=0.1246 μM SANGER
DMS-53 Growth Inhibition Assay IC50=0.12276 μM SANGER
S-117 Growth Inhibition Assay IC50=0.12674 μM SANGER
ChaGo-K-1 Growth Inhibition Assay IC50=0.12699 μM SANGER
PC-3 Growth Inhibition Assay IC50=0.13177 μM SANGER
KMS-12-PE Growth Inhibition Assay IC50=0.12869 μM SANGER
RERF-LC-MS Growth Inhibition Assay IC50=0.1343 μM SANGER
GMS-10 Growth Inhibition Assay IC50=0.13444 μM SANGER
SCC-25 Growth Inhibition Assay IC50=0.13588 μM SANGER
CTB-1 Growth Inhibition Assay IC50=0.13469 μM SANGER
D-542MG Growth Inhibition Assay IC50=0.13965 μM SANGER
NCI-H1755 Growth Inhibition Assay IC50=0.13827 μM SANGER
KARPAS-422 Growth Inhibition Assay IC50=0.14037 μM SANGER
OVCAR-3 Growth Inhibition Assay IC50=0.14078 μM SANGER
NCI-H1092 Growth Inhibition Assay IC50=0.14101 μM SANGER
HH Growth Inhibition Assay IC50=0.14201 μM SANGER
NB1 Growth Inhibition Assay IC50=0.14426 μM SANGER
HD-MY-Z Growth Inhibition Assay IC50=0.14429 μM SANGER
SHP-77 Growth Inhibition Assay IC50=0.14472 μM SANGER
GI-1 Growth Inhibition Assay IC50=0.14772 μM SANGER
U-266 Growth Inhibition Assay IC50=0.1448 μM SANGER
NCI-H1522 Growth Inhibition Assay IC50=0.14787 μM SANGER
HCT-116 Growth Inhibition Assay IC50=0.15169 μM SANGER
647-V Growth Inhibition Assay IC50=0.14942 μM SANGER
NCI-H2081 Growth Inhibition Assay IC50=0.15218 μM SANGER
THP-1 Growth Inhibition Assay IC50=0.15333 μM SANGER
RCM-1 Growth Inhibition Assay IC50=0.1568 μM SANGER
LU-165 Growth Inhibition Assay IC50=0.15413 μM SANGER
COR-L279 Growth Inhibition Assay IC50=0.15836 μM SANGER
SK-NEP-1 Growth Inhibition Assay IC50=0.15899 μM SANGER
NCI-H2170 Growth Inhibition Assay IC50=0.16304 μM SANGER
KLE Growth Inhibition Assay IC50=0.16169 μM SANGER
TGW Growth Inhibition Assay IC50=0.16471 μM SANGER
CAL-72 Growth Inhibition Assay IC50=0.1659 μM SANGER
COR-L88 Growth Inhibition Assay IC50=0.17114 μM SANGER
K052 Growth Inhibition Assay IC50=0.17061 μM SANGER
HSC-4 Growth Inhibition Assay IC50=0.1716 μM SANGER
GOTO Growth Inhibition Assay IC50=0.17246 μM SANGER
MDA-MB-134-VI Growth Inhibition Assay IC50=0.17367 μM SANGER
MEG-01 Growth Inhibition Assay IC50=0.17257 μM SANGER
NCI-H596 Growth Inhibition Assay IC50=0.1738 μM SANGER
EW-3 Growth Inhibition Assay IC50=0.17486 μM SANGER
NCI-H1573 Growth Inhibition Assay IC50=0.17678 μM SANGER
SK-N-DZ Growth Inhibition Assay IC50=0.17883 μM SANGER
SKG-IIIa Growth Inhibition Assay IC50=0.17807 μM SANGER
EGI-1 Growth Inhibition Assay IC50=0.1797 μM SANGER
COLO-320-HSR Growth Inhibition Assay IC50=0.18493 μM SANGER
MS-1 Growth Inhibition Assay IC50=0.186 μM SANGER
DOHH-2 Growth Inhibition Assay IC50=0.18569 μM SANGER
NCI-H526 Growth Inhibition Assay IC50=0.18696 μM SANGER
NCI-H2171 Growth Inhibition Assay IC50=0.18649 μM SANGER
MDA-MB-415 Growth Inhibition Assay IC50=0.19748 μM SANGER
C2BBe1 Growth Inhibition Assay IC50=0.19893 μM SANGER
ECC4 Growth Inhibition Assay IC50=0.19863 μM SANGER
TE-11 Growth Inhibition Assay IC50=0.19975 μM SANGER
MKN45 Growth Inhibition Assay IC50=0.2064 μM SANGER
LU-65 Growth Inhibition Assay IC50=0.20211 μM SANGER
TGBC1TKB Growth Inhibition Assay IC50=0.20997 μM SANGER
M14 Growth Inhibition Assay IC50=0.21803 μM SANGER
NCI-H2196 Growth Inhibition Assay IC50=0.21747 μM SANGER
NCI-H1436 Growth Inhibition Assay IC50=0.21826 μM SANGER
HT Growth Inhibition Assay IC50=0.22566 μM SANGER
EB-3 Growth Inhibition Assay IC50=0.22376 μM SANGER
A3-KAW Growth Inhibition Assay IC50=0.22708 μM SANGER
KARPAS-299 Growth Inhibition Assay IC50=0.22994 μM SANGER
DB Growth Inhibition Assay IC50=0.22865 μM SANGER
IM-9 Growth Inhibition Assay IC50=0.23476 μM SANGER
NCI-H838 Growth Inhibition Assay IC50=0.23714 μM SANGER
NCI-H2141 Growth Inhibition Assay IC50=0.23841 μM SANGER
NB10 Growth Inhibition Assay IC50=0.23731 μM SANGER
LB647-SCLC Growth Inhibition Assay IC50=0.24014 μM SANGER
NCI-H23 Growth Inhibition Assay IC50=0.24059 μM SANGER
MN-60 Growth Inhibition Assay IC50=0.24239 μM SANGER
CAL-148 Growth Inhibition Assay IC50=0.24282 μM SANGER
EFE-184 Growth Inhibition Assay IC50=0.24597 μM SANGER
TE-6 Growth Inhibition Assay IC50=0.24612 μM SANGER
SN12C Growth Inhibition Assay IC50=0.24694 μM SANGER
CAKI-1 Growth Inhibition Assay IC50=0.25086 μM SANGER
MHH-NB-11 Growth Inhibition Assay IC50=0.2535 μM SANGER
DOK Growth Inhibition Assay IC50=0.2593 μM SANGER
Raji Growth Inhibition Assay IC50=0.26603 μM SANGER
OAW-28 Growth Inhibition Assay IC50=0.26677 μM SANGER
P30-OHK Growth Inhibition Assay IC50=0.26905 μM SANGER
NCI-H69 Growth Inhibition Assay IC50=0.27201 μM SANGER
SK-N-AS Growth Inhibition Assay IC50=0.2722 μM SANGER
BE-13 Growth Inhibition Assay IC50=0.27249 μM SANGER
NCI-H1618 Growth Inhibition Assay IC50=0.2751 μM SANGER
NCI-SNU-5 Growth Inhibition Assay IC50=0.27613 μM SANGER
NCI-H1694 Growth Inhibition Assay IC50=0.27733 μM SANGER
RL Growth Inhibition Assay IC50=0.28174 μM SANGER
SW684 Growth Inhibition Assay IC50=0.28383 μM SANGER
NCI-H510A Growth Inhibition Assay IC50=0.29304 μM SANGER
EW-24 Growth Inhibition Assay IC50=0.2881 μM SANGER
LB373-MEL-D Growth Inhibition Assay IC50=0.29431 μM SANGER
Mo-T Growth Inhibition Assay IC50=0.29331 μM SANGER
NCI-H28 Growth Inhibition Assay IC50=0.29837 μM SANGER
L-540 Growth Inhibition Assay IC50=0.30089 μM SANGER
NCI-H446 Growth Inhibition Assay IC50=0.29921 μM SANGER
MKN7 Growth Inhibition Assay IC50=0.30639 μM SANGER
OPM-2 Growth Inhibition Assay IC50=0.31064 μM SANGER
BT-20 Growth Inhibition Assay IC50=0.31099 μM SANGER
KP-N-YN Growth Inhibition Assay IC50=0.31118 μM SANGER
MDA-MB-175-VII Growth Inhibition Assay IC50=0.32348 μM SANGER
EFM-19 Growth Inhibition Assay IC50=0.33132 μM SANGER
COLO-678 Growth Inhibition Assay IC50=0.33389 μM SANGER
COLO-829 Growth Inhibition Assay IC50=0.34452 μM SANGER
A704 Growth Inhibition Assay IC50=0.34923 μM SANGER
NCI-H719 Growth Inhibition Assay IC50=0.35124 μM SANGER
MFE-280 Growth Inhibition Assay IC50=0.35715 μM SANGER
DMS-114 Growth Inhibition Assay IC50=0.3612 μM SANGER
SK-N-FI Growth Inhibition Assay IC50=0.37637 μM SANGER
RMG-I Growth Inhibition Assay IC50=0.36691 μM SANGER
LB2518-MEL Growth Inhibition Assay IC50=0.40872 μM SANGER
IST-MES1 Growth Inhibition Assay IC50=0.411 μM SANGER
HPAF-II Growth Inhibition Assay IC50=0.41117 μM SANGER
NCI-H1882 Growth Inhibition Assay IC50=0.41784 μM SANGER
JVM-2 Growth Inhibition Assay IC50=0.44401 μM SANGER
T47D Growth Inhibition Assay IC50=0.44528 μM SANGER
MHH-CALL-2 Growth Inhibition Assay IC50=0.4483 μM SANGER
NCI-H716 Growth Inhibition Assay IC50=0.44848 μM SANGER
NEC8 Growth Inhibition Assay IC50=0.45145 μM SANGER
UACC-812 Growth Inhibition Assay IC50=0.46776 μM SANGER
D-502MG Growth Inhibition Assay IC50=0.4803 μM SANGER
CaR-1 Growth Inhibition Assay IC50=0.50367 μM SANGER
LU-139 Growth Inhibition Assay IC50=0.51457 μM SANGER
SW1088 Growth Inhibition Assay IC50=0.53869 μM SANGER
RPMI-8402 Growth Inhibition Assay IC50=0.52207 μM SANGER
JVM-3 Growth Inhibition Assay IC50=0.54117 μM SANGER
YAPC Growth Inhibition Assay IC50=0.55211 μM SANGER
KG-1 Growth Inhibition Assay IC50=0.55984 μM SANGER
C32 Growth Inhibition Assay IC50=0.57313 μM SANGER
IST-SL1 Growth Inhibition Assay IC50=0.60435 μM SANGER
NCI-H2126 Growth Inhibition Assay IC50=0.63152 μM SANGER
HCC1954 Growth Inhibition Assay IC50=0.64726 μM SANGER
WM-115 Growth Inhibition Assay IC50=0.65092 μM SANGER
NB6 Growth Inhibition Assay IC50=0.67335 μM SANGER
TYK-nu Growth Inhibition Assay IC50=0.67952 μM SANGER
KY821 Growth Inhibition Assay IC50=0.70229 μM SANGER
SIMA Growth Inhibition Assay IC50=0.71719 μM SANGER
LN-405 Growth Inhibition Assay IC50=0.7436 μM SANGER
RCC10RGB Growth Inhibition Assay IC50=0.71918 μM SANGER
NCI-H1155 Growth Inhibition Assay IC50=0.74868 μM SANGER
SCLC-21H Growth Inhibition Assay IC50=0.76903 μM SANGER
DMS-79 Growth Inhibition Assay IC50=0.77845 μM SANGER
KNS-42 Growth Inhibition Assay IC50=0.78831 μM SANGER
EC-GI-10 Growth Inhibition Assay IC50=0.77975 μM SANGER
SF539 Growth Inhibition Assay IC50=0.79925 μM SANGER
SNU-475 Growth Inhibition Assay IC50=0.79202 μM SANGER
SW1417 Growth Inhibition Assay IC50=0.81339 μM SANGER
PLC-PRF-5 Growth Inhibition Assay IC50=0.88475 μM SANGER
ATN-1 Growth Inhibition Assay IC50=0.85115 μM SANGER
MDA-MB-453 Growth Inhibition Assay IC50=0.90304 μM SANGER
HT-3 Growth Inhibition Assay IC50=0.8942 μM SANGER
NCI-H1993 Growth Inhibition Assay IC50=1.04657 μM SANGER
HAL-01 Growth Inhibition Assay IC50=0.99379 μM SANGER
NCI-H2227 Growth Inhibition Assay IC50=1.04981 μM SANGER
LP-1 Growth Inhibition Assay IC50=1.0693 μM SANGER
P31-FUJ Growth Inhibition Assay IC50=1.10766 μM SANGER
NCI-H64 Growth Inhibition Assay IC50=1.1542 μM SANGER
SW1463 Growth Inhibition Assay IC50=1.18349 μM SANGER
SK-MEL-1 Growth Inhibition Assay IC50=1.20595 μM SANGER
TALL-1 Growth Inhibition Assay IC50=1.25165 μM SANGER
RO82-W-1 Growth Inhibition Assay IC50=1.33339 μM SANGER
NCI-H1581 Growth Inhibition Assay IC50=1.35687 μM SANGER
NCI-H748 Growth Inhibition Assay IC50=1.35738 μM SANGER
EoL-1-cell Growth Inhibition Assay IC50=1.58889 μM SANGER
HCC1187 Growth Inhibition Assay IC50=1.55522 μM SANGER
NCI-H1793 Growth Inhibition Assay IC50=1.87593 μM SANGER
HuO-3N1 Growth Inhibition Assay IC50=1.83412 μM SANGER
Caov-3 Growth Inhibition Assay IC50=2.00625 μM SANGER
JAR Growth Inhibition Assay IC50=2.0792 μM SANGER
SK-MEL-28 Growth Inhibition Assay IC50=2.18098 μM SANGER
Mewo Growth Inhibition Assay IC50=2.22265 μM SANGER
EM-2 Growth Inhibition Assay IC50=2.20293 μM SANGER
NCI-H720 Growth Inhibition Assay IC50=2.26585 μM SANGER
CAL-54 Growth Inhibition Assay IC50=2.26795 μM SANGER
MC116 Growth Inhibition Assay IC50=2.36397 μM SANGER
DG-75 Growth Inhibition Assay IC50=2.48576 μM SANGER
FTC-133 Growth Inhibition Assay IC50=2.53689 μM SANGER
HCC1143 Growth Inhibition Assay IC50=2.50658 μM SANGER
NCI-H889 Growth Inhibition Assay IC50=2.56706 μM SANGER
AsPC-1 Growth Inhibition Assay IC50=2.53929 μM SANGER
UMC-11 Growth Inhibition Assay IC50=2.78715 μM SANGER
HT55 Growth Inhibition Assay IC50=2.62019 μM SANGER
P12-ICHIKAWA Growth Inhibition Assay IC50=2.82046 μM SANGER
HCC1395 Growth Inhibition Assay IC50=2.98602 μM SANGER
D-283MED Growth Inhibition Assay IC50=3.18937 μM SANGER
COLO-800 Growth Inhibition Assay IC50=3.33897 μM SANGER
MFM-223 Growth Inhibition Assay IC50=3.36097 μM SANGER
TE-5 Growth Inhibition Assay IC50=4.56147 μM SANGER
NCI-H209 Growth Inhibition Assay IC50=4.78572 μM SANGER
SiHa Growth Inhibition Assay IC50=4.95203 μM SANGER
NCI-H1395 Growth Inhibition Assay IC50=5.10633 μM SANGER
A498 Growth Inhibition Assay IC50=5.21251 μM SANGER
ES5 Growth Inhibition Assay IC50=5.61178 μM SANGER
MDA-MB-157 Growth Inhibition Assay IC50=5.66443 μM SANGER
NCI-H1623 Growth Inhibition Assay IC50=5.83556 μM SANGER
RPMI-8866 Growth Inhibition Assay IC50=5.84792 μM SANGER
LC-1F Growth Inhibition Assay IC50=6.09291 μM SANGER
TCCSUP Growth Inhibition Assay IC50=6.60349 μM SANGER
TT Growth Inhibition Assay IC50=8.33009 μM SANGER
NCI-H322M Growth Inhibition Assay IC50=9.16281 μM SANGER
NCI-H1838 Growth Inhibition Assay IC50=8.51731 μM SANGER
NCI-H187 Growth Inhibition Assay IC50=9.51835 μM SANGER
SBC-1 Growth Inhibition Assay IC50=9.93656 μM SANGER
SCC-3 Growth Inhibition Assay IC50=10.5679 μM SANGER
CPC-N Growth Inhibition Assay IC50=11.007 μM SANGER
SW948 Growth Inhibition Assay IC50=10.7511 μM SANGER
TGBC24TKB Growth Inhibition Assay IC50=13.529 μM SANGER
NCI-H2452 Growth Inhibition Assay IC50=14.73 μM SANGER
Hs-578-T Growth Inhibition Assay IC50=18.5759 μM SANGER
DV-90 Growth Inhibition Assay IC50=18.9945 μM SANGER
NCI-H1563 Growth Inhibition Assay IC50=19.7888 μM SANGER
NCI-H345 Growth Inhibition Assay IC50=21.8779 μM SANGER
SW780 Growth Inhibition Assay IC50=21.1318 μM SANGER
LB771-HNC Growth Inhibition Assay IC50=22.4813 μM SANGER
RT4 Growth Inhibition Assay IC50=23.3282 μM SANGER
NCI-H82 Growth Inhibition Assay IC50=23.5526 μM SANGER
NCI-H524 Growth Inhibition Assay IC50=24.3812 μM SANGER
SNU-C1 Growth Inhibition Assay IC50=24.9105 μM SANGER
NCI-SNU-16 Growth Inhibition Assay IC50=48.3142 μM SANGER
COLO-792 Growth Inhibition Assay IC50=0.08855 μM SANGER
ES3 Growth Inhibition Assay IC50=0.08763 μM SANGER
LAN-6 Growth Inhibition Assay IC50=0.08498 μM SANGER
ABC-1 Growth Inhibition Assay IC50=0.08759 μM SANGER
CP50-MEL-B Growth Inhibition Assay IC50=0.08368 μM SANGER
KP-N-YS Growth Inhibition Assay IC50=0.08345 μM SANGER
NCI-H1304 Growth Inhibition Assay IC50=0.08271 μM SANGER
COLO-684 Growth Inhibition Assay IC50=0.08158 μM SANGER
LNCaP-Clone-FGC Growth Inhibition Assay IC50=0.08165 μM SANGER
NCI-H2347 Growth Inhibition Assay IC50=0.08028 μM SANGER
CAL-27 Growth Inhibition Assay IC50=0.08156 μM SANGER
COLO-668 Growth Inhibition Assay IC50=0.07984 μM SANGER
SK-CO-1 Growth Inhibition Assay IC50=0.07992 μM SANGER
MV-4-11 Growth Inhibition Assay IC50=0.000558 μM SANGER
CMK Growth Inhibition Assay IC50=0.000125 μM SANGER
HOS Growth Inhibition Assay IC50=0.00138 μM SANGER
NALM-6 Growth Inhibition Assay IC50=0.000842 μM SANGER
TE-8 Growth Inhibition Assay IC50=0.00237 μM SANGER
SW1710 Growth Inhibition Assay IC50=0.00186 μM SANGER
HT-144 Growth Inhibition Assay IC50=0.00155 μM SANGER
PSN1 Growth Inhibition Assay IC50=0.00318 μM SANGER
CCF-STTG1 Growth Inhibition Assay IC50=0.00297 μM SANGER
ES1 Growth Inhibition Assay IC50=0.00266 μM SANGER
CAL-51 Growth Inhibition Assay IC50=0.00325 μM SANGER
MCF7 Growth Inhibition Assay IC50=0.00335 μM SANGER
HMV-II Growth Inhibition Assay IC50=0.00449 μM SANGER
LCLC-103H Growth Inhibition Assay IC50=0.0043 μM SANGER
SK-HEP-1 Growth Inhibition Assay IC50=0.00336 μM SANGER
MES-SA Growth Inhibition Assay IC50=0.00452 μM SANGER
SIG-M5 Growth Inhibition Assay IC50=0.00489 μM SANGER
639-V Growth Inhibition Assay IC50=0.00485 μM SANGER
SK-LMS-1 Growth Inhibition Assay IC50=0.00458 μM SANGER
HSC-2 Growth Inhibition Assay IC50=0.00518 μM SANGER
LOUCY Growth Inhibition Assay IC50=0.00505 μM SANGER
RT-112 Growth Inhibition Assay IC50=0.00535 μM SANGER
EW-13 Growth Inhibition Assay IC50=0.00518 μM SANGER
KYSE-180 Growth Inhibition Assay IC50=0.00586 μM SANGER
NKM-1 Growth Inhibition Assay IC50=0.00547 μM SANGER
A431 Growth Inhibition Assay IC50=0.00607 μM SANGER
SW1783 Growth Inhibition Assay IC50=0.00591 μM SANGER
RPMI-7951 Growth Inhibition Assay IC50=0.00631 μM SANGER
SK-OV-3 Growth Inhibition Assay IC50=0.0063 μM SANGER
HSC-3 Growth Inhibition Assay IC50=0.00641 μM SANGER
Capan-2 Growth Inhibition Assay IC50=0.00638 μM SANGER
Daoy Growth Inhibition Assay IC50=0.00695 μM SANGER
786-0 Growth Inhibition Assay IC50=0.00663 μM SANGER
EW-16 Growth Inhibition Assay IC50=0.00749 μM SANGER
KGN Growth Inhibition Assay IC50=0.00703 μM SANGER
IGROV-1 Growth Inhibition Assay IC50=0.00814 μM SANGER
EW-7 Growth Inhibition Assay IC50=0.00754 μM SANGER
8505C Growth Inhibition Assay IC50=0.00821 μM SANGER
IST-MEL1 Growth Inhibition Assay IC50=0.00852 μM SANGER
GDM-1 Growth Inhibition Assay IC50=0.0084 μM SANGER
RKO Growth Inhibition Assay IC50=0.00826 μM SANGER
RPMI-6666 Growth Inhibition Assay IC50=0.00852 μM SANGER
SNG-M Growth Inhibition Assay IC50=0.00856 μM SANGER
RXF393 Growth Inhibition Assay IC50=0.0086 μM SANGER
KS-1 Growth Inhibition Assay IC50=0.00859 μM SANGER
BFTC-905 Growth Inhibition Assay IC50=0.00938 μM SANGER
CAL-12T Growth Inhibition Assay IC50=0.00922 μM SANGER
SK-MES-1 Growth Inhibition Assay IC50=0.00945 μM SANGER
AN3-CA Growth Inhibition Assay IC50=0.01017 μM SANGER
BB30-HNC Growth Inhibition Assay IC50=0.00952 μM SANGER
G-401 Growth Inhibition Assay IC50=0.01025 μM SANGER
EFO-27 Growth Inhibition Assay IC50=0.01017 μM SANGER
NCI-H727 Growth Inhibition Assay IC50=0.0103 μM SANGER
BPH-1 Growth Inhibition Assay IC50=0.0103 μM SANGER
KYSE-270 Growth Inhibition Assay IC50=0.01059 μM SANGER
SNU-423 Growth Inhibition Assay IC50=0.01053 μM SANGER
NCI-H2228 Growth Inhibition Assay IC50=0.01064 μM SANGER
AGS Growth Inhibition Assay IC50=0.01061 μM SANGER
SW954 Growth Inhibition Assay IC50=0.01071 μM SANGER
IA-LM Growth Inhibition Assay IC50=0.01086 μM SANGER
BB49-HNC Growth Inhibition Assay IC50=0.01077 μM SANGER
769-P Growth Inhibition Assay IC50=0.01073 μM SANGER
NB69 Growth Inhibition Assay IC50=0.01102 μM SANGER
C8166 Growth Inhibition Assay IC50=0.01129 μM SANGER
YKG-1 Growth Inhibition Assay IC50=0.0116 μM SANGER
NCI-H1299 Growth Inhibition Assay IC50=0.01154 μM SANGER
YT Growth Inhibition Assay IC50=0.01179 μM SANGER
PANC-03-27 Growth Inhibition Assay IC50=0.01162 μM SANGER
GT3TKB Growth Inhibition Assay IC50=0.01202 μM SANGER
CAL-85-1 Growth Inhibition Assay IC50=0.01192 μM SANGER
ES6 Growth Inhibition Assay IC50=0.01261 μM SANGER
BB65-RCC Growth Inhibition Assay IC50=0.01204 μM SANGER
MHH-ES-1 Growth Inhibition Assay IC50=0.01263 μM SANGER
OCI-AML2 Growth Inhibition Assay IC50=0.01281 μM SANGER
SNU-C2B Growth Inhibition Assay IC50=0.01272 μM SANGER
QIMR-WIL Growth Inhibition Assay IC50=0.01269 μM SANGER
SW982 Growth Inhibition Assay IC50=0.01293 μM SANGER
DU-145 Growth Inhibition Assay IC50=0.0129 μM SANGER
MFH-ino Growth Inhibition Assay IC50=0.01293 μM SANGER
A427 Growth Inhibition Assay IC50=0.01299 μM SANGER
K5 Growth Inhibition Assay IC50=0.01308 μM SANGER
AM-38 Growth Inhibition Assay IC50=0.01302 μM SANGER
LCLC-97TM1 Growth Inhibition Assay IC50=0.013 μM SANGER
TE-15 Growth Inhibition Assay IC50=0.01336 μM SANGER
T84 Growth Inhibition Assay IC50=0.01331 μM SANGER
NCI-H460 Growth Inhibition Assay IC50=0.01336 μM SANGER
NTERA-S-cl-D1 Growth Inhibition Assay IC50=0.01339 μM SANGER
H4 Growth Inhibition Assay IC50=0.01366 μM SANGER
KYSE-450 Growth Inhibition Assay IC50=0.01349 μM SANGER
GAMG Growth Inhibition Assay IC50=0.01371 μM SANGER
LC-2-ad Growth Inhibition Assay IC50=0.0137 μM SANGER
NCI-H2122 Growth Inhibition Assay IC50=0.01384 μM SANGER
TK10 Growth Inhibition Assay IC50=0.01382 μM SANGER
KM12 Growth Inhibition Assay IC50=0.01399 μM SANGER
KYSE-510 Growth Inhibition Assay IC50=0.01442 μM SANGER
RPMI-2650 Growth Inhibition Assay IC50=0.01432 μM SANGER
CAL-39 Growth Inhibition Assay IC50=0.0142 μM SANGER
KALS-1 Growth Inhibition Assay IC50=0.01466 μM SANGER
NCI-H1648 Growth Inhibition Assay IC50=0.01499 μM SANGER
ES4 Growth Inhibition Assay IC50=0.01502 μM SANGER
C-33-A Growth Inhibition Assay IC50=0.01509 μM SANGER
HOP-62 Growth Inhibition Assay IC50=0.01542 μM SANGER
Becker Growth Inhibition Assay IC50=0.01514 μM SANGER
MIA-PaCa-2 Growth Inhibition Assay IC50=0.01509 μM SANGER
KYSE-410 Growth Inhibition Assay IC50=0.01586 μM SANGER
TE-1 Growth Inhibition Assay IC50=0.01581 μM SANGER
MEL-HO Growth Inhibition Assay IC50=0.01643 μM SANGER
NOS-1 Growth Inhibition Assay IC50=0.01593 μM SANGER
NCI-H1650 Growth Inhibition Assay IC50=0.01646 μM SANGER
ACN Growth Inhibition Assay IC50=0.01657 μM SANGER
HuP-T3 Growth Inhibition Assay IC50=0.01653 μM SANGER
VMRC-RCZ Growth Inhibition Assay IC50=0.01651 μM SANGER
HT-1197 Growth Inhibition Assay IC50=0.01685 μM SANGER
MEL-JUSO Growth Inhibition Assay IC50=0.01681 μM SANGER
A4-Fuk Growth Inhibition Assay IC50=0.01702 μM SANGER
NCI-H2030 Growth Inhibition Assay IC50=0.01697 μM SANGER
A2780 Growth Inhibition Assay IC50=0.01715 μM SANGER
NCI-H292 Growth Inhibition Assay IC50=0.01709 μM SANGER
NCI-H810 Growth Inhibition Assay IC50=0.01724 μM SANGER
SF295 Growth Inhibition Assay IC50=0.01721 μM SANGER
ALL-PO Growth Inhibition Assay IC50=0.01735 μM SANGER
NY Growth Inhibition Assay IC50=0.0174 μM SANGER
MC-IXC Growth Inhibition Assay IC50=0.01736 μM SANGER
OMC-1 Growth Inhibition Assay IC50=0.01751 μM SANGER
NCI-H2342 Growth Inhibition Assay IC50=0.01758 μM SANGER
PANC-10-05 Growth Inhibition Assay IC50=0.01755 μM SANGER
TE-12 Growth Inhibition Assay IC50=0.01775 μM SANGER
HGC-27 Growth Inhibition Assay IC50=0.01758 μM SANGER
MOLT-16 Growth Inhibition Assay IC50=0.01788 μM SANGER
OVCAR-5 Growth Inhibition Assay IC50=0.01812 μM SANGER
HL-60 Growth Inhibition Assay IC50=0.01807 μM SANGER
MG-63 Growth Inhibition Assay IC50=0.01874 μM SANGER
SK-LU-1 Growth Inhibition Assay IC50=0.01846 μM SANGER
COR-L105 Growth Inhibition Assay IC50=0.01911 μM SANGER
8-MG-BA Growth Inhibition Assay IC50=0.01884 μM SANGER
SW620 Growth Inhibition Assay IC50=0.01915 μM SANGER
BHY Growth Inhibition Assay IC50=0.01912 μM SANGER
PC-14 Growth Inhibition Assay IC50=0.01934 μM SANGER
NCI-H522 Growth Inhibition Assay IC50=0.01939 μM SANGER
OE19 Growth Inhibition Assay IC50=0.0195 μM SANGER
A101D Growth Inhibition Assay IC50=0.01987 μM SANGER
TE-10 Growth Inhibition Assay IC50=0.01977 μM SANGER
RVH-421 Growth Inhibition Assay IC50=0.01957 μM SANGER
HUTU-80 Growth Inhibition Assay IC50=0.02004 μM SANGER
KYSE-140 Growth Inhibition Assay IC50=0.02024 μM SANGER
SNU-449 Growth Inhibition Assay IC50=0.02026 μM SANGER
697 Growth Inhibition Assay IC50=0.02031 μM SANGER
SJSA-1 Growth Inhibition Assay IC50=0.02037 μM SANGER
IGR-1 Growth Inhibition Assay IC50=0.0205 μM SANGER
GCIY Growth Inhibition Assay IC50=0.02055 μM SANGER
REH Growth Inhibition Assay IC50=0.02059 μM SANGER
A204 Growth Inhibition Assay IC50=0.02115 μM SANGER
NCI-H650 Growth Inhibition Assay IC50=0.02117 μM SANGER
A388 Growth Inhibition Assay IC50=0.02115 μM SANGER
SW626 Growth Inhibition Assay IC50=0.0212 μM SANGER
DoTc2-4510 Growth Inhibition Assay IC50=0.02122 μM SANGER
HCE-4 Growth Inhibition Assay IC50=0.02145 μM SANGER
DU-4475 Growth Inhibition Assay IC50=0.0215 μM SANGER
A375 Growth Inhibition Assay IC50=0.02171 μM SANGER
GB-1 Growth Inhibition Assay IC50=0.02188 μM SANGER
HT-1080 Growth Inhibition Assay IC50=0.02214 μM SANGER
CHP-212 Growth Inhibition Assay IC50=0.02212 μM SANGER
M059J Growth Inhibition Assay IC50=0.02241 μM SANGER
NMC-G1 Growth Inhibition Assay IC50=0.0228 μM SANGER
MFE-296 Growth Inhibition Assay IC50=0.02322 μM SANGER
MRK-nu-1 Growth Inhibition Assay IC50=0.023 μM SANGER
LOXIMVI Growth Inhibition Assay IC50=0.02323 μM SANGER
CGTH-W-1 Growth Inhibition Assay IC50=0.02328 μM SANGER
CCRF-CEM Growth Inhibition Assay IC50=0.02329 μM SANGER
ACHN Growth Inhibition Assay IC50=0.02345 μM SANGER
NCI-H1355 Growth Inhibition Assay IC50=0.02401 μM SANGER
NCI-H1651 Growth Inhibition Assay IC50=0.02431 μM SANGER
KINGS-1 Growth Inhibition Assay IC50=0.02433 μM SANGER
LS-123 Growth Inhibition Assay IC50=0.02435 μM SANGER
SNB75 Growth Inhibition Assay IC50=0.02466 μM SANGER
C3A Growth Inhibition Assay IC50=0.02475 μM SANGER
HO-1-N-1 Growth Inhibition Assay IC50=0.02549 μM SANGER
EHEB Growth Inhibition Assay IC50=0.02555 μM SANGER
CAL-62 Growth Inhibition Assay IC50=0.0257 μM SANGER
U-118-MG Growth Inhibition Assay IC50=0.02576 μM SANGER
HN Growth Inhibition Assay IC50=0.02593 μM SANGER
HTC-C3 Growth Inhibition Assay IC50=0.02607 μM SANGER
KYSE-520 Growth Inhibition Assay IC50=0.02613 μM SANGER
MZ1-PC Growth Inhibition Assay IC50=0.02639 μM SANGER
BCPAP Growth Inhibition Assay IC50=0.02646 μM SANGER
RD Growth Inhibition Assay IC50=0.02658 μM SANGER
LXF-289 Growth Inhibition Assay IC50=0.02668 μM SANGER
NCI-H520 Growth Inhibition Assay IC50=0.02664 μM SANGER
G-361 Growth Inhibition Assay IC50=0.02677 μM SANGER
COR-L23 Growth Inhibition Assay IC50=0.02713 μM SANGER
LB996-RCC Growth Inhibition Assay IC50=0.0271 μM SANGER
GP5d Growth Inhibition Assay IC50=0.02723 μM SANGER
SW1990 Growth Inhibition Assay IC50=0.02724 μM SANGER
PA-1 Growth Inhibition Assay IC50=0.02755 μM SANGER
NCI-H2009 Growth Inhibition Assay IC50=0.0276 μM SANGER
SR Growth Inhibition Assay IC50=0.02785 μM SANGER
Ca9-22 Growth Inhibition Assay IC50=0.02796 μM SANGER
SCC-15 Growth Inhibition Assay IC50=0.02801 μM SANGER
ETK-1 Growth Inhibition Assay IC50=0.02806 μM SANGER
SCC-4 Growth Inhibition Assay IC50=0.02809 μM SANGER
5637 Growth Inhibition Assay IC50=0.02822 μM SANGER
EW-1 Growth Inhibition Assay IC50=0.02822 μM SANGER
SW962 Growth Inhibition Assay IC50=0.02852 μM SANGER
HCE-T Growth Inhibition Assay IC50=0.0286 μM SANGER
NCI-H2405 Growth Inhibition Assay IC50=0.02887 μM SANGER
A2058 Growth Inhibition Assay IC50=0.02929 μM SANGER
HCC2998 Growth Inhibition Assay IC50=0.02945 μM SANGER
ONS-76 Growth Inhibition Assay IC50=0.02954 μM SANGER
DBTRG-05MG Growth Inhibition Assay IC50=0.02955 μM SANGER
HuCCT1 Growth Inhibition Assay IC50=0.02961 μM SANGER
J82 Growth Inhibition Assay IC50=0.03007 μM SANGER
MKN28 Growth Inhibition Assay IC50=0.03012 μM SANGER
SW837 Growth Inhibition Assay IC50=0.03014 μM SANGER
no-10 Growth Inhibition Assay IC50=0.03016 μM SANGER
BC-3 Growth Inhibition Assay IC50=0.03018 μM SANGER
8305C Growth Inhibition Assay IC50=0.03072 μM SANGER
no-11 Growth Inhibition Assay IC50=0.03048 μM SANGER
COLO-679 Growth Inhibition Assay IC50=0.03107 μM SANGER
CESS Growth Inhibition Assay IC50=0.0312 μM SANGER
BFTC-909 Growth Inhibition Assay IC50=0.03125 μM SANGER
MZ2-MEL Growth Inhibition Assay IC50=0.03177 μM SANGER
LB831-BLC Growth Inhibition Assay IC50=0.03219 μM SANGER
SW872 Growth Inhibition Assay IC50=0.03217 μM SANGER
NCI-H1734 Growth Inhibition Assay IC50=0.0323 μM SANGER
SK-UT-1 Growth Inhibition Assay IC50=0.03221 μM SANGER
OVCAR-8 Growth Inhibition Assay IC50=0.03281 μM SANGER
NCI-H2087 Growth Inhibition Assay IC50=0.03289 μM SANGER
U-87-MG Growth Inhibition Assay IC50=0.0329 μM SANGER
BC-1 Growth Inhibition Assay IC50=0.03367 μM SANGER
ES7 Growth Inhibition Assay IC50=0.03374 μM SANGER
RS4-11 Growth Inhibition Assay IC50=0.03383 μM SANGER
Daudi Growth Inhibition Assay IC50=0.03376 μM SANGER
JiyoyeP-2003 Growth Inhibition Assay IC50=0.03388 μM SANGER
OS-RC-2 Growth Inhibition Assay IC50=0.03396 μM SANGER
BL-70 Growth Inhibition Assay IC50=0.03389 μM SANGER
SF268 Growth Inhibition Assay IC50=0.03401 μM SANGER
BV-173 Growth Inhibition Assay IC50=0.03426 μM SANGER
DMS-273 Growth Inhibition Assay IC50=0.03479 μM SANGER
ES8 Growth Inhibition Assay IC50=0.03538 μM SANGER
22RV1 Growth Inhibition Assay IC50=0.03507 μM SANGER
KYSE-150 Growth Inhibition Assay IC50=0.03608 μM SANGER
HCC1569 Growth Inhibition Assay IC50=0.03608 μM SANGER
NB5 Growth Inhibition Assay IC50=0.03613 μM SANGER
G-402 Growth Inhibition Assay IC50=0.03614 μM SANGER
NCI-H1693 Growth Inhibition Assay IC50=0.03617 μM SANGER
LB2241-RCC Growth Inhibition Assay IC50=0.03642 μM SANGER
KP-4 Growth Inhibition Assay IC50=0.03663 μM SANGER
ML-2 Growth Inhibition Assay IC50=0.03671 μM SANGER
KU812 Growth Inhibition Assay IC50=0.03684 μM SANGER
LS-411N Growth Inhibition Assay IC50=0.03731 μM SANGER
OAW-42 Growth Inhibition Assay IC50=0.03747 μM SANGER
HCC38 Growth Inhibition Assay IC50=0.03771 μM SANGER
Calu-3 Growth Inhibition Assay IC50=0.03789 μM SANGER
Ca-Ski Growth Inhibition Assay IC50=0.03784 μM SANGER
KYSE-70 Growth Inhibition Assay IC50=0.03812 μM SANGER
OVCAR-4 Growth Inhibition Assay IC50=0.03858 μM SANGER
D-392MG Growth Inhibition Assay IC50=0.03842 μM SANGER
HEL Growth Inhibition Assay IC50=0.03891 μM SANGER
Detroit562 Growth Inhibition Assay IC50=0.03872 μM SANGER
MONO-MAC-6 Growth Inhibition Assay IC50=0.03893 μM SANGER
LoVo Growth Inhibition Assay IC50=0.03933 μM SANGER
U-2-OS Growth Inhibition Assay IC50=0.03935 μM SANGER
A172 Growth Inhibition Assay IC50=0.0395 μM SANGER
OCUB-M Growth Inhibition Assay IC50=0.03961 μM SANGER
SW48 Growth Inhibition Assay IC50=0.04031 μM SANGER
HC-1 Growth Inhibition Assay IC50=0.04069 μM SANGER
HDLM-2 Growth Inhibition Assay IC50=0.04114 μM SANGER
KOSC-2 Growth Inhibition Assay IC50=0.0411 μM SANGER
CTV-1 Growth Inhibition Assay IC50=0.04116 μM SANGER
SH-4 Growth Inhibition Assay IC50=0.04141 μM SANGER
SW756 Growth Inhibition Assay IC50=0.04157 μM SANGER
GCT Growth Inhibition Assay IC50=0.04161 μM SANGER
CHL-1 Growth Inhibition Assay IC50=0.04169 μM SANGER
LS-1034 Growth Inhibition Assay IC50=0.04191 μM SANGER
LAMA-84 Growth Inhibition Assay IC50=0.04171 μM SANGER
NCI-H358 Growth Inhibition Assay IC50=0.04212 μM SANGER
NB13 Growth Inhibition Assay IC50=0.04227 μM SANGER
TE-9 Growth Inhibition Assay IC50=0.04237 μM SANGER
OE33 Growth Inhibition Assay IC50=0.04241 μM SANGER
CAL-120 Growth Inhibition Assay IC50=0.04241 μM SANGER
DJM-1 Growth Inhibition Assay IC50=0.04272 μM SANGER
VA-ES-BJ Growth Inhibition Assay IC50=0.04292 μM SANGER
SK-MEL-24 Growth Inhibition Assay IC50=0.04283 μM SANGER
MMAC-SF Growth Inhibition Assay IC50=0.04297 μM SANGER
MZ7-mel Growth Inhibition Assay IC50=0.0433 μM SANGER
BxPC-3 Growth Inhibition Assay IC50=0.04341 μM SANGER
HT-29 Growth Inhibition Assay IC50=0.04357 μM SANGER
SK-MEL-30 Growth Inhibition Assay IC50=0.04362 μM SANGER
COLO-680N Growth Inhibition Assay IC50=0.04407 μM SANGER
CAL-33 Growth Inhibition Assay IC50=0.04375 μM SANGER
NH-12 Growth Inhibition Assay IC50=0.0444 μM SANGER
HCC1937 Growth Inhibition Assay IC50=0.04456 μM SANGER
IMR-5 Growth Inhibition Assay IC50=0.0449 μM SANGER
MC-CAR Growth Inhibition Assay IC50=0.04569 μM SANGER
NCI-H747 Growth Inhibition Assay IC50=0.0457 μM SANGER
NCI-H1792 Growth Inhibition Assay IC50=0.04581 μM SANGER
SW13 Growth Inhibition Assay IC50=0.0459 μM SANGER
MLMA Growth Inhibition Assay IC50=0.04609 μM SANGER
U251 Growth Inhibition Assay IC50=0.04763 μM SANGER
U031 Growth Inhibition Assay IC50=0.04771 μM SANGER
ME-180 Growth Inhibition Assay IC50=0.04782 μM SANGER
SK-MEL-3 Growth Inhibition Assay IC50=0.04802 μM SANGER
MOLT-4 Growth Inhibition Assay IC50=0.04803 μM SANGER
NUGC-3 Growth Inhibition Assay IC50=0.04827 μM SANGER
PF-382 Growth Inhibition Assay IC50=0.04826 μM SANGER
NCI-H1417 Growth Inhibition Assay IC50=0.0489 μM SANGER
COLO-205 Growth Inhibition Assay IC50=0.04919 μM SANGER
TE-441-T Growth Inhibition Assay IC50=0.0493 μM SANGER
MKN1 Growth Inhibition Assay IC50=0.0493 μM SANGER
UM-UC-3 Growth Inhibition Assay IC50=0.0495 μM SANGER
SF126 Growth Inhibition Assay IC50=0.0501 μM SANGER
A253 Growth Inhibition Assay IC50=0.05052 μM SANGER
LB1047-RCC Growth Inhibition Assay IC50=0.05031 μM SANGER
NCI-H1963 Growth Inhibition Assay IC50=0.05176 μM SANGER
VM-CUB-1 Growth Inhibition Assay IC50=0.05311 μM SANGER
T-24 Growth Inhibition Assay IC50=0.05384 μM SANGER
K-562 Growth Inhibition Assay IC50=0.05387 μM SANGER
ARH-77 Growth Inhibition Assay IC50=0.05395 μM SANGER
CA46 Growth Inhibition Assay IC50=0.0543 μM SANGER
HCC70 Growth Inhibition Assay IC50=0.05452 μM SANGER
ST486 Growth Inhibition Assay IC50=0.05525 μM SANGER
COLO-741 Growth Inhibition Assay IC50=0.05531 μM SANGER
SK-PN-DW Growth Inhibition Assay IC50=0.05588 μM SANGER
D-263MG Growth Inhibition Assay IC50=0.05683 μM SANGER
BL-41 Growth Inhibition Assay IC50=0.05596 μM SANGER
KE-37 Growth Inhibition Assay IC50=0.05683 μM SANGER
LU-134-A Growth Inhibition Assay IC50=0.05715 μM SANGER
HCC2157 Growth Inhibition Assay IC50=0.05733 μM SANGER
IST-SL2 Growth Inhibition Assay IC50=0.05743 μM SANGER
GAK Growth Inhibition Assay IC50=0.05734 μM SANGER
KMOE-2 Growth Inhibition Assay IC50=0.05749 μM SANGER
SW1573 Growth Inhibition Assay IC50=0.05802 μM SANGER
SCC-9 Growth Inhibition Assay IC50=0.0587 μM SANGER
MDA-MB-361 Growth Inhibition Assay IC50=0.05872 μM SANGER
BHT-101 Growth Inhibition Assay IC50=0.05876 μM SANGER
NCI-H1770 Growth Inhibition Assay IC50=0.05879 μM SANGER
UACC-893 Growth Inhibition Assay IC50=0.05896 μM SANGER
NCI-H226 Growth Inhibition Assay IC50=0.05988 μM SANGER
HLE Growth Inhibition Assay IC50=0.06082 μM SANGER
NCI-H1703 Growth Inhibition Assay IC50=0.06178 μM SANGER
KURAMOCHI Growth Inhibition Assay IC50=0.06189 μM SANGER
RH-1 Growth Inhibition Assay IC50=0.0623 μM SANGER
CAMA-1 Growth Inhibition Assay IC50=0.06303 μM SANGER
DSH1 Growth Inhibition Assay IC50=0.0627 μM SANGER
NCI-H1437 Growth Inhibition Assay IC50=0.06328 μM SANGER
HuP-T4 Growth Inhibition Assay IC50=0.06586 μM SANGER
HCT-15 Growth Inhibition Assay IC50=0.06597 μM SANGER
NCCIT Growth Inhibition Assay IC50=0.06604 μM SANGER
BOKU Growth Inhibition Assay IC50=0.06674 μM SANGER
FADU Growth Inhibition Assay IC50=0.06745 μM SANGER
SUP-T1 Growth Inhibition Assay IC50=0.0676 μM SANGER
L-363 Growth Inhibition Assay IC50=0.06901 μM SANGER
KNS-81-FD Growth Inhibition Assay IC50=0.06918 μM SANGER
SU-DHL-1 Growth Inhibition Assay IC50=0.0692 μM SANGER
HuH-7 Growth Inhibition Assay IC50=0.07035 μM SANGER
CAPAN-1 Growth Inhibition Assay IC50=0.07143 μM SANGER
BT-474 Growth Inhibition Assay IC50=0.07061 μM SANGER
HEC-1 Growth Inhibition Assay IC50=0.07161 μM SANGER
NOMO-1 Growth Inhibition Assay IC50=0.07172 μM SANGER
KM-H2 Growth Inhibition Assay IC50=0.07241 μM SANGER
EB2 Growth Inhibition Assay IC50=0.07285 μM SANGER
LU-99A Growth Inhibition Assay IC50=0.07287 μM SANGER
WSU-NHL Growth Inhibition Assay IC50=0.07329 μM SANGER
Calu-1 Growth Inhibition Assay IC50=0.07332 μM SANGER
U-698-M Growth Inhibition Assay IC50=0.07382 μM SANGER
GI-ME-N Growth Inhibition Assay IC50=0.07426 μM SANGER
T98G Growth Inhibition Assay IC50=0.07421 μM SANGER
LS-513 Growth Inhibition Assay IC50=0.07456 μM SANGER
UACC-257 Growth Inhibition Assay IC50=0.07505 μM SANGER
DK-MG Growth Inhibition Assay IC50=0.07526 μM SANGER
CHP-126 Growth Inhibition Assay IC50=0.07565 μM SANGER
EW-11 Growth Inhibition Assay IC50=0.07535 μM SANGER
Ramos-2G6-4C10 Growth Inhibition Assay IC50=0.07648 μM SANGER
Saos-2 Growth Inhibition Assay IC50=0.07597 μM SANGER
L-428 Growth Inhibition Assay IC50=0.07704 μM SANGER
HOP-92 Growth Inhibition Assay IC50=0.07711 μM SANGER
PANC-08-13 Growth Inhibition Assay IC50=0.07716 μM SANGER
TUR Growth Inhibition Assay IC50=0.07733 μM SANGER
DMS-153 Growth Inhibition Assay IC50=0.07735 μM SANGER
NCI-N87 Growth Inhibition Assay IC50=0.07799 μM SANGER
ESS-1 Growth Inhibition Assay IC50=0.07868 μM SANGER
NCI-SNU-1 Growth Inhibition Assay IC50=0.07888 μM SANGER
CP66-MEL Growth Inhibition Assay IC50=0.07887 μM SANGER
Calu-6 Growth Inhibition Assay IC50=0.07965 μM SANGER
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生物活性

製品説明 Luminespib (AUY-922, NVP-AUY922, VER-52296) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Luminespib (AUY-922, NVP-AUY922) effectively downregulates and destabilizes the IGF-1Rβ protein and results in growth inhibition, autophagy and apoptosis. Phase 2.
Targets
HSP90α [1]
(Cell-free assay)		 HSP90β [1]
(Cell-free assay)
13 nM 21 nM
In Vitro
In vitro NVP-AUY922 inhibits proliferation of various human cancer cell lines in vitro, with an average GI50 of 9 nM. [1] The IC50 values of NVP-AUY922 fall in the range of 2 to 40 nM in these gastric cancer cell lines. IC50 value for the BEAS-2B cells is 28.49 nM. Treatment with NVP-AUY922 does not influence the expression of HSP90, but expression of HSP70 gets elevated by NVP-AUY922 treatment. NVP-AUY922 increases the binding of HSP70 to HSP90. NVP-AUY922 causes p23 dissociation from the HSP90 complex and can then recruit HSP70 to the HSP90 complex. [1] After the treatment with NVP-AUY922, expression of receptor tyrosine kinases including VEGFR1, 2, 3 and PDGFRɑ is decreased. A decrease is also noticed in the expression of Akt and phospho-Akt. Meanwhile, treatment with NVP-AUY922 causes decreased expression of HER-2 in NCI-N87 cells. NVP-AUY922 treatment results in binding of HSP90 to client proteins and setting them up as targets for degradation by the proteasome. NVP-AUY922 can influence cell growth by affecting multiple signaling pathways. In addition, treatment with the proteasome inhibitor, MG132, restores expression of thymidylate synthase, which is decreased by NVP-AUY922. NVP-AUY922 increases the expression of cleaved caspase-3 leading to apoptosis in HSC-2 cells.[1]
Kinase Assay Kinase assay
NVP-AUY922 is dissolved in DMSO at a concentration of 10 mM. NVP-AUY922 is assessed against HSP90α, HSP90β, GRP94, TRAP-1, HSP72, and topoisomerase II. Profiling against a panel of kinases has been carried out and screening against a panel of additional enzymes and receptors is performed at Cerep.
細胞実験 細胞株 Human gastric cancer cells NCI-N87
濃度 1 μM
反応時間 3 days
実験の流れ Human gastric cancer cells NCI-N87 (5-7 ×103 in 50 μL/well) are seeded in 96-well plates and incubated at 37 °C for 24 hours, followed by NVP-AUY922 treatment for 1-3 days at 37 °C. After treatment, the cells are assayed by MTT method and analyzed by microplate reader.
実験結果図 Methods Biomarkers 結果図 PMID
Western blot p-ALK / ALK / p-AKT / AKT / p-ERK / ERK / TβRI / TβRII E-cadherin / Cleaved PARP / Bim HSP70 / Grp94 / Grp78 / p-eIF2α / CHOP / IRE1α / p-JNK CDK4 / HMGA2 23993685
Growth inhibition assay Cell viability 26893968
In Vivo
In Vivo Treatment with NVP-AUY922 causes a robust antitumor response and inhibits p-Akt and VEGF expression in an HSC-2 xenograft model. [2] In BT474, NVP-AUY922 shows complete loss of ERBB2 and substantial depletion of ERα, in addition to reductions in CDK4 and phospho-ERK1/2. [3]
動物実験 動物モデル Female NCr athymic mice bearing WM266.4 human melanoma xenografts
投与量 50 mg/kg
投与経路 Administered via i.v. or i.p.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01772797 Completed
Anaplastic Lymphoma Kinase (ALK)|Non-small Cell Lung Cancer
Novartis Pharmaceuticals|Novartis
 June 2013 Phase 1
NCT01752400 Completed
Non Small Cell Lung Cancer
Massachusetts General Hospital
 January 2013 Phase 2
NCT01613950 Completed
Stomach Neoplasms Esophageal Neoplasms Metastatic Gastric Cancer Mutated PI3KCA Protein Overexpressed HER2 Protein
Novartis Pharmaceuticals|Novartis
 December 2012 Phase 1
NCT01484860 Terminated
Adenocarcinoma of the Pancreas|Metastatic Disease
University Health Network Toronto|Novartis Pharmaceuticals
 January 2012 Phase 2
NCT01402401 Terminated
Advanced Gastric Cancer
Novartis Pharmaceuticals|Novartis
 November 2011 Phase 2

化学情報

分子量 465.54 化学式

C26H31N3O5
CAS No. 747412-49-3 SDF Download Luminespib (NVP-AUY922) SDFをダウンロードする
Smiles CCNC(=O)C1=NOC(=C1C2=CC=C(C=C2)CN3CCOCC3)C4=CC(=C(C=C4O)O)C(C)C
保管

In vitro
Batch:

DMSO : 93 mg/mL ( (199.76 mM)； 吸湿したDMSOは溶解度を減少させます。新しいDMSOをご使用ください。)

Ethanol : 31 mg/mL

Water : Insoluble

モル濃度計算器

in vivo
Batch:

Add solvents to the product individually and in order.

投与溶液組成計算機

実験計算

モル濃度計算器

質量 濃度 体積 分子量

投与溶液組成計算機(クリア溶液)

ステップ１：実験データを入力してください。（実験操作によるロスを考慮し、動物数を1匹分多くして計算・調製することを推奨します）

mg/kg g μL 匹

ステップ２：投与溶媒の組成を入力してください。（ロット毎に適した溶解組成が異なる場合があります。詳細については弊社までお問い合わせください）

% DMSO % % Tween 80 % ddH2O
%DMSO %

計算結果：

投与溶媒濃度： mg/ml;

DMSOストック溶液調製方法： mg 試薬を μL DMSOに溶解する（濃度 mg/mL, 注：濃度が当該ロットのDMSO溶解度を超える場合はご連絡ください。 )

投与溶媒調製方法：Take μL DMSOストック溶液に μL PEG300，を加え、完全溶解後μL Tween 80，を加えて完全溶解させた後 μL ddH2O，を加え完全に溶解させます。

投与溶媒調製方法：μL DMSOストック溶液に μL Corn oil，を加え、完全溶解。

注意：１.ストック溶液に沈殿、混濁などがないことをご確認ください；
２.順番通りに溶剤を加えてください。次のステップに進む前に溶液に沈殿、混濁などがないことを確認してから加えてください。ボルテックス、ソニケーション、水浴加熱など物理的な方法で溶解を早めることは可能です。

技術サポート

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Handling Instructions

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