GABA Receptor

GABA Receptor製品

• All (73)
• GABA Receptor阻害剤 (10)
• GABA Receptor活性剤(6)
• GABA Receptor拮抗剤(14)
• GABA Receptor作動薬(15)
• GABA Receptorモジュレータ(12)
• 新製品

製品コード	製品名称	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S1168	Valproic Acid sodium	Valproic Acid sodium is a HDAC inhibitor by selectively inducing proteasomal degradation of HDAC2, used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches. Valproic acid induces Notch1 signaling in small cell lung cancer (SCLC) cells. Valproic acid is under investigation for treatment of HIV and various cancers. Valproic acid (VPA) induces autophagy and mitophagy by upregulation of BNIP3 and mitochondrial biogenesis by upregulating PGC-1α.	J Exp Clin Cancer Res, 2024, 43(1):152 J Immunother Cancer, 2024, 12(11)e009805 Sci Total Environ, 2022, 838(Pt 2):155825
S7071	(+)-Bicuculline	(+)-Bicuculline (d-Bicuculline) is a competitive antagonist of GABAA receptors with IC50 of 2 μM, also blocks Ca(2+)-activated potassium channels.	Commun Biol, 2024, 7(1):1408 Research Square, 2024, 10.21203/rs.3.rs-3480364/v1 J Exp Med, 2022, 219-12e20220541
S6611	Cyclothiazide	Cyclothiazide is a positive allosteric modulator of ionotropic α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)-type glutamate receptors with critical roles in neurological development and function.	Nucleic Acids Res, 2024, gkae761 J Immunother Cancer, 2024, 12(11)e009805 Adv Sci (Weinh), 2023, 10(3):e2203718
S2399	Dihydromyricetin	Dihydromyricetin (Ampelopsin, Ampeloptin) is a natural antioxidant flavonoid from Ampelopsis grossedentata.	Front Pharmacol, 2022, 13:932092 Molecules, 2021, 26(5)1210 Cell Signal, 2020, 65:109431
S2133	Gabapentin	Gabapentin is a GABA analogue, used to treat seizures and neuropathic pain.	Mol Oncol, 2022, 10.1002/1878-0261.13281 Mol Pharmacol, 2022, 101(4):236-245 Cell Death Dis, 2020, 11(9):764
S1332	Flumazenil	Flumazenil is a competitive GABAA receptor antagonist, used in the treatment of benzodiazepine overdoses.	J Exp Med, 2022, 219-12e20220541 Biomed Pharmacother, 2018, 107:1674-1681 Holist Nurs Pract, 2017, 31(3):193-203
S1338	Gabapentin HCl	Gabapentin HCl(Neurontin HCl) is a GABA analogue, used to treat seizures and neuropathic pain.	Mol Pharmacol, 2022, 101(4):236-245 Int J Clin Exp Pathol, 2018, 11(12):5536-5546 J Aging Sci, 2017, 5:1
S0303	CGP52432	CGP52432 is a potent and selective antagonist of GABAB autoreceptor with IC50 of 0.085 μM.	Research Square, 2024, 10.21203/rs.3.rs-3480364/v1 J Cell Biochem, 2022, 10.1002/jcb.30231 Front Neurosci, 2021, 15:741214
S3072	(R)-baclofen	(R)-baclofen (STX 209) is a derivative of gamma-aminobutyric acid primarily used to treat spasticity.	J Cell Biochem, 2022, 10.1002/jcb.30231
S3018	Niflumic acid	Niflumic acid is an inhibitor of cyclooxygenase-2 used for joint and muscular pain.	Oncol Lett, 2020, 20(4):39
S2026	Ginkgolide A	Ginkgolide A (BN52020) is an extract from in Ginkgo biloba and a g-aminobutyric acid (GABA) antagonist with a Ki of 14.5 μM.	Cell Rep, 2020, 21;31(3):107521
S5194	Furosemide sodium	Furosemide (Frusemide) sodium is a potent and orally active inhibitor of Na-K-Cl cotransporter (NKCC). Furosemide sodium is a subtype-selective antagonist of gamma-aminobutyric acid type A (GABAA) receptor.	Nat Commun, 2024, 15(1):7342 Ren Fail, 2022, 44(1):1345-1355
S3786	Glabridin	Glabridin (Q-100692, KB-289522, LS-176045), one of the active phytochemicals in licorice extract, binds to and activates the ligand binding domain of PPARγ, as well as the full length receptor. It is also a GABAA receptor positive modulator promoting fatty acid oxidation and improving learning and memory.	Life Sci, 2021, S0024-3205(20)31752-5
S4700	4-Aminobutyric acid (GABA)	4-Aminobutyric acid (4-Aminobutanoic acid, GABA, Gamma-aminobutyric acid, Piperidic acid) is a naturally occurring neurotransmitter with central nervous system (CNS) inhibitory activity.	Theranostics, 2023, 13(4):1355-1369
S1969	Nefiracetam	Nefiracetam (DZL 221) is a GABAergic, cholinergic, and monoaminergic neuronal system enhancer for Ro 5-4864-induced convulsions. Phase 2.
E1247	SR95531	Gabazine(SR95531) is a potent competitive and allosteric antagonist of the GABAA receptor, with an IC50 for the GABA receptor of 9 µM.
E2848	Afoxolaner	Afoxolaner (NexGard) is a new insecticide/acaricide molecule from the isoxazoline family that acts on the insect gamma-aminobutyric acid receptor (GABA) and glutamate receptors, inhibiting GABA & glutamate-regulated uptake of chloride ions, resulting in excess neuronal stimulation and death of the arthropod.
S5131	Homotaurine	Homotaurine (Tramiprosate, Alzhemed, 3-Amino-1-propanesulfonic acid) is a synthetic organic compound that has GABAergic activity by mimicking GABA. It is a GABAA partial agonist as well as a GABAB receptor partial agonist with low efficacy.
S3959	(+)-Borneol	(+)-Borneol is one of enantiomers of borneol which is a valuable medical material, senior aromatic spice, and chemical material and has been used in food and also folk medicine.
S4840	Baclofen	Baclofen is a gamma-amino-butyric acid (GABA) derivative used as a skeletal muscle relaxant and central nervous system depressant. It activates GABA receptors, specifically the GABAB receptors.
S2996	L-DAB HBR	L-DAB HBR (L-Dab Hydrobromide, L-2,4-Diaminobutyric acid hydrobromide) is an inhibitor of GABA (Gamma-aminobutyric acid) transaminase with IC50 of >500 μM. L-DAB HBR exhibits antitumor activity.
S3634	6-Hydroxyflavone (6-HF)	6-Hydroxyflavone, a naturally occurring flavonoid, binds to GABAA receptors with moderate affinity and acts as a partial agonist of GABAA receptors.
E2354	Valepotriate	Valepotriate, an unstable iridoid isolated from Valeriana jatamansi Jones, has anti-epileptic by significantly increasing the expression of GABAA, glutamic acid decarboxylase 65, and Bcl-2 and reduce the expression of caspase-3.
S0049	Zuranolone (SAGE-217)	Zuranolone(SAGE-217, CS-2797) is an orally active and potent neuroactive steroid and positive allosteric modulator of the GABAA receptor, with EC50s of 296 nM for α1β2γ2 receptor.
S5596	(1S)-(-)-α-Pinene	α-Pinene is found in the oils of many species of many coniferous trees, notably the pine and has insecticidal activity.
S9249	Securinine	Securinine, a major natural alkaloid product from the root of the plant Securinega suffruticosa, acts as a γ-amino butyric acid (GABA) receptor antagonist.
S4892	Phenibut	Phenibut (Aminophenylbutyric acid, Fenibut, Phenigam, Phenybut, PhGABA, β-Phenyl-γ-aminobutyric acid, β-Phenyl-GABA), a GABA analogue, is a central nervous system depressant with anxiolytic and sedative effects.
S5805	Allopregnanolone	Allopregnanolone, a neurosteroid synthesized from progesterone in brain, acts as a highly potent positive allosteric modulator of the GABAA receptor.
S4587	Pentylenetetrazol	Pentylenetetrazol (Pentylenetetrazole, Metrazole, pentetrazol, pentamethylenetetrazol, Corazol, Cardiazol, PTZ) displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GABA(A) receptor antagonist.	Cell Mol Life Sci, 2024, 81(1):104
E0599	Arecaidine hydrochloride	Arecaidine hydrochloride, a constituent of the nut of Areca catechu, inhibits the uptake of GABA and beta-alanine, but not that of glycine.
E0101	AZD6280	AZD6280 is a selective GABAA (α2/3) receptor modulator, used for treatment of generalized anxiety disorder.
S4961	3,4,5-Trimethoxycinnamic acid	3,4,5-Trimethoxycinnamic acid (TMCA) is one of the constituents of Polygalae Radix and may exert anti-seizure activity by acting at the GABAA/BZ receptor complex.
E4920New	Baclofen hydrochloride	Baclofen hydrochloride is an agonist of the GABAB receptor that mimics the action of GABA, leading to slow presynaptic inhibition via the GABAB receptor. It improves the function of the ubiquitin-proteasome system (UPS) and enhances cell survival in both in vitro and in vivo models of Huntington's disease (HD).
S4661	Tiagabine hydrochloride	Tiagabine Hydrochloride (Gabitril, NO050328, NO328, TGB) is the hydrochloride salt form of tiagabine, a nipecotic acid derivative with anticonvulsant property. A selective gamma-aminobutyric acid (GABA) reuptake inhibitor.
S3663	Afloqualone	Afloqualone (AFQ, HQ-495) is a quinazolinone family GABAergic drug with muscle-relaxant and sedative effects, showing the agonist activity at the β subtype of the GABAa receptor.
S4675	Tiagabine	Tiagabine (Gabitril, NO050328, NO328, TGB) is an anti-convulsive medication and a selective gamma-aminobutyric acid (GABA) reuptake inhibitor.
S6008	p-Hydroxybenzaldehyde	p-Hydroxybenzaldehyde (4-Hydroxybenzaldehyde, 4-Formylphenol, p-Formylphenol), which can be found in the orchids Gastrodia elata, Galeola faberi and vanilla, is a hydroxybenzaldehyde that reacts with NAD+ and H2O to produce 4-hydroxybenzoate, NADH, and 2 protons.
S9065	Songorine	Songorine, a ubiquitous alkaloid in the genus Aconitum, is a novel antagonist of the GABAA receptor in rat brain and has antiarrhythmic, antinociceptive, anti-inflammatory, regenerative and CNS-modulating properties.
S1989	GABAA receptor agent 1	GABAA receptor agent 1 is a high affinity ligand for Gamma-aminobutyric acid A (GABAA) receptor that exerts potent anticonvulsant activity.
S4197	Bemegride	Bemegride(Bemegrid,3-Ethyl-3-methylglutarimide) is a central nervous system stimulant and antidote for barbiturate poisoning.
S5049	Thiocolchicoside	Thiocolchicoside (Thiocolchicine 2-glucoside analog, Coltramyl) is a natural occuring glycoside originated from the flower seeds of superba gloriosa with anti-inflammatory and analgesic properties as well as pronounced convulsant activity. It is also an antagonist of GABAA receptor.
S4270	Oxiracetam	Oxiracetam (ISF 2522), a cyclic derivative of gamma-aminobutyric acid (GABA), is used as a nootropic drug to improve memory and learning.	Eur J Pharmacol, 2024, 979:176835
S0164	AZD7325	AZD7325 is a potent and orally active partial selective Positive allosteric modulator (PAM) of GABAAα2 and Aα3 receptor with Ki=0.3 and 1.3 nM, respectively, and has less antagonistic efficacy at the Aα1 and Aα5 receptor subtypes.
S9409	Kavain	Kavain, the main kavalactone found mostly in the roots of the kava plant, has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na+ and Ca2+ channels.
S6094	Imidazole-4(5)-acetic Acid Hydrochloride	Imidazole-4(5)-acetic Acid Hydrochloride is a competitive antagonist at GABAC receptors.
E2232	Guvacine hydrochloride	Guvacine hydrochloride is an alkaloid from the nut of Areca catechu, acts as an inhibitor of GABA transporter, and displays modest selectivity for cloned GABA transporters with IC50s of 14 μM (human GAT-1), 39 μM (rat GAT-1), 58 μM (rat GAT-2), 119 μM (human GAT-3), 378 μM (rat GAT-3), and 1870 μM (human BGT-3).
S4772	alpha-Asarone	Alpha (α)-asarone (trans-Asarone) is one of the main pharmacologically active compounds present in Acorus calamus Linn (Acoraceae), Acorus tatarinowii Schott (Acoraceae), and Acorus gramineus Solander. It has anticonvulsant, neuroprotective, anxiolytic and nootropic effects.
S5319	Imepitoin	Imepitoin(ELB-138,AWD 131-138) is a centrally acting anti-epileptic which crosses the blood brain barrier and is used for the treatment of canine idiopathic epilepsy.
S6100	Picrotoxin	Picrotoxin (Picrotin, Cocculin, Cocculus, NSC 403139), a plant alkaloid, is a non-competitive antagonist of neuronal GABA and glycine receptors.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing.
S3748	Acamprosate Calcium	Acamprosate (N-Acetylhomotaurine, Calcium acetylhomotaurinate,N-acetylhomotaurinate) is a synthetic compound with a chemical structure similar to the amino acid neurotransmitter gamma-aminobutyric acid (GABA) and the amino acid neuromodulator taurine.
S4423	Emamectin Benzoate	Emamectin Benzoate (EMB, MK-244) activates gamma-amino butyric acid (GABA) transporter. Emamectin Benzoate induces of reactive oxygen species (ROS)-mediated DNA damage and apoptosis.
S6470	Fluralaner	Fluralaner (A1443, AH252723) is a systemic insecticide and acaricide that is administered orally.Fluralaner inhibits γ-aminobutyric acid (GABA)-gated chloride channels (GABAA receptors) and L-glutamate-gated chloride channels (GluCls).
S3977	(-)-Borneol	(-)-Borneol (L-Borneol), one of enantiomers of borneol, has a camphoraceous and evident woody odor.
S4494	Methionine	Methionine (MRX-1024, D-Methionine) is an activitor of GABAA receptor that modulates neuronal activity.
S9176	Pimpinellin	Pimpinellin is a furocoumarin that acts as antagonist of proteins with GABA receptor activity.
S5612	Isonipecotic acid	Isonipecotic acid (4-Piperidinecarboxylic acid, 4-Carboxypiperidine, Hexahydroisonicotinic acid) is a heterocyclic compound that mainly acts as a GABAA receptor partial agonist.
S6755	NS 11394	NS11394 is a subtype-selective positive allosteric modulator at GABAA receptors, with selectivity for the α3 and α5 subtypes.
E0960	RO5186582	RO5186582 (Basmisanil, RG1662) is a highly selective GABAAα5 negative allosteric modulator.
S2399	Dihydromyricetin	Dihydromyricetin (Ampelopsin, Ampeloptin) is a natural antioxidant flavonoid from Ampelopsis grossedentata.	Front Pharmacol, 2022, 13:932092 Molecules, 2021, 26(5)1210 Cell Signal, 2020, 65:109431
S2133	Gabapentin	Gabapentin is a GABA analogue, used to treat seizures and neuropathic pain.	Mol Oncol, 2022, 10.1002/1878-0261.13281 Mol Pharmacol, 2022, 101(4):236-245 Cell Death Dis, 2020, 11(9):764
S1338	Gabapentin HCl	Gabapentin HCl(Neurontin HCl) is a GABA analogue, used to treat seizures and neuropathic pain.	Mol Pharmacol, 2022, 101(4):236-245 Int J Clin Exp Pathol, 2018, 11(12):5536-5546 J Aging Sci, 2017, 5:1
S3072	(R)-baclofen	(R)-baclofen (STX 209) is a derivative of gamma-aminobutyric acid primarily used to treat spasticity.	J Cell Biochem, 2022, 10.1002/jcb.30231
S3786	Glabridin	Glabridin (Q-100692, KB-289522, LS-176045), one of the active phytochemicals in licorice extract, binds to and activates the ligand binding domain of PPARγ, as well as the full length receptor. It is also a GABAA receptor positive modulator promoting fatty acid oxidation and improving learning and memory.	Life Sci, 2021, S0024-3205(20)31752-5
S4700	4-Aminobutyric acid (GABA)	4-Aminobutyric acid (4-Aminobutanoic acid, GABA, Gamma-aminobutyric acid, Piperidic acid) is a naturally occurring neurotransmitter with central nervous system (CNS) inhibitory activity.	Theranostics, 2023, 13(4):1355-1369
S4840	Baclofen	Baclofen is a gamma-amino-butyric acid (GABA) derivative used as a skeletal muscle relaxant and central nervous system depressant. It activates GABA receptors, specifically the GABAB receptors.
S3634	6-Hydroxyflavone (6-HF)	6-Hydroxyflavone, a naturally occurring flavonoid, binds to GABAA receptors with moderate affinity and acts as a partial agonist of GABAA receptors.
S4892	Phenibut	Phenibut (Aminophenylbutyric acid, Fenibut, Phenigam, Phenybut, PhGABA, β-Phenyl-γ-aminobutyric acid, β-Phenyl-GABA), a GABA analogue, is a central nervous system depressant with anxiolytic and sedative effects.
S4961	3,4,5-Trimethoxycinnamic acid	3,4,5-Trimethoxycinnamic acid (TMCA) is one of the constituents of Polygalae Radix and may exert anti-seizure activity by acting at the GABAA/BZ receptor complex.
E4920New	Baclofen hydrochloride	Baclofen hydrochloride is an agonist of the GABAB receptor that mimics the action of GABA, leading to slow presynaptic inhibition via the GABAB receptor. It improves the function of the ubiquitin-proteasome system (UPS) and enhances cell survival in both in vitro and in vivo models of Huntington's disease (HD).
S3663	Afloqualone	Afloqualone (AFQ, HQ-495) is a quinazolinone family GABAergic drug with muscle-relaxant and sedative effects, showing the agonist activity at the β subtype of the GABAa receptor.
S4270	Oxiracetam	Oxiracetam (ISF 2522), a cyclic derivative of gamma-aminobutyric acid (GABA), is used as a nootropic drug to improve memory and learning.	Eur J Pharmacol, 2024, 979:176835
S3748	Acamprosate Calcium	Acamprosate (N-Acetylhomotaurine, Calcium acetylhomotaurinate,N-acetylhomotaurinate) is a synthetic compound with a chemical structure similar to the amino acid neurotransmitter gamma-aminobutyric acid (GABA) and the amino acid neuromodulator taurine.
S5612	Isonipecotic acid	Isonipecotic acid (4-Piperidinecarboxylic acid, 4-Carboxypiperidine, Hexahydroisonicotinic acid) is a heterocyclic compound that mainly acts as a GABAA receptor partial agonist.
S1168	Valproic Acid sodium	Valproic Acid sodium is a HDAC inhibitor by selectively inducing proteasomal degradation of HDAC2, used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches. Valproic acid induces Notch1 signaling in small cell lung cancer (SCLC) cells. Valproic acid is under investigation for treatment of HIV and various cancers. Valproic acid (VPA) induces autophagy and mitophagy by upregulation of BNIP3 and mitochondrial biogenesis by upregulating PGC-1α.	J Exp Clin Cancer Res, 2024, 43(1):152 J Immunother Cancer, 2024, 12(11)e009805 Sci Total Environ, 2022, 838(Pt 2):155825
S3018	Niflumic acid	Niflumic acid is an inhibitor of cyclooxygenase-2 used for joint and muscular pain.	Oncol Lett, 2020, 20(4):39
E1247	SR95531	Gabazine(SR95531) is a potent competitive and allosteric antagonist of the GABAA receptor, with an IC50 for the GABA receptor of 9 µM.
E2848	Afoxolaner	Afoxolaner (NexGard) is a new insecticide/acaricide molecule from the isoxazoline family that acts on the insect gamma-aminobutyric acid receptor (GABA) and glutamate receptors, inhibiting GABA & glutamate-regulated uptake of chloride ions, resulting in excess neuronal stimulation and death of the arthropod.
S2996	L-DAB HBR	L-DAB HBR (L-Dab Hydrobromide, L-2,4-Diaminobutyric acid hydrobromide) is an inhibitor of GABA (Gamma-aminobutyric acid) transaminase with IC50 of >500 μM. L-DAB HBR exhibits antitumor activity.
E0599	Arecaidine hydrochloride	Arecaidine hydrochloride, a constituent of the nut of Areca catechu, inhibits the uptake of GABA and beta-alanine, but not that of glycine.
S4661	Tiagabine hydrochloride	Tiagabine Hydrochloride (Gabitril, NO050328, NO328, TGB) is the hydrochloride salt form of tiagabine, a nipecotic acid derivative with anticonvulsant property. A selective gamma-aminobutyric acid (GABA) reuptake inhibitor.
S4675	Tiagabine	Tiagabine (Gabitril, NO050328, NO328, TGB) is an anti-convulsive medication and a selective gamma-aminobutyric acid (GABA) reuptake inhibitor.
E2232	Guvacine hydrochloride	Guvacine hydrochloride is an alkaloid from the nut of Areca catechu, acts as an inhibitor of GABA transporter, and displays modest selectivity for cloned GABA transporters with IC50s of 14 μM (human GAT-1), 39 μM (rat GAT-1), 58 μM (rat GAT-2), 119 μM (human GAT-3), 378 μM (rat GAT-3), and 1870 μM (human BGT-3).
S6470	Fluralaner	Fluralaner (A1443, AH252723) is a systemic insecticide and acaricide that is administered orally.Fluralaner inhibits γ-aminobutyric acid (GABA)-gated chloride channels (GABAA receptors) and L-glutamate-gated chloride channels (GluCls).
S1969	Nefiracetam	Nefiracetam (DZL 221) is a GABAergic, cholinergic, and monoaminergic neuronal system enhancer for Ro 5-4864-induced convulsions. Phase 2.
E2354	Valepotriate	Valepotriate, an unstable iridoid isolated from Valeriana jatamansi Jones, has anti-epileptic by significantly increasing the expression of GABAA, glutamic acid decarboxylase 65, and Bcl-2 and reduce the expression of caspase-3.
S4772	alpha-Asarone	Alpha (α)-asarone (trans-Asarone) is one of the main pharmacologically active compounds present in Acorus calamus Linn (Acoraceae), Acorus tatarinowii Schott (Acoraceae), and Acorus gramineus Solander. It has anticonvulsant, neuroprotective, anxiolytic and nootropic effects.
S5319	Imepitoin	Imepitoin(ELB-138,AWD 131-138) is a centrally acting anti-epileptic which crosses the blood brain barrier and is used for the treatment of canine idiopathic epilepsy.
S4423	Emamectin Benzoate	Emamectin Benzoate (EMB, MK-244) activates gamma-amino butyric acid (GABA) transporter. Emamectin Benzoate induces of reactive oxygen species (ROS)-mediated DNA damage and apoptosis.
S4494	Methionine	Methionine (MRX-1024, D-Methionine) is an activitor of GABAA receptor that modulates neuronal activity.
S7071	(+)-Bicuculline	(+)-Bicuculline (d-Bicuculline) is a competitive antagonist of GABAA receptors with IC50 of 2 μM, also blocks Ca(2+)-activated potassium channels.	Commun Biol, 2024, 7(1):1408 Research Square, 2024, 10.21203/rs.3.rs-3480364/v1 J Exp Med, 2022, 219-12e20220541
S1332	Flumazenil	Flumazenil is a competitive GABAA receptor antagonist, used in the treatment of benzodiazepine overdoses.	J Exp Med, 2022, 219-12e20220541 Biomed Pharmacother, 2018, 107:1674-1681 Holist Nurs Pract, 2017, 31(3):193-203
S0303	CGP52432	CGP52432 is a potent and selective antagonist of GABAB autoreceptor with IC50 of 0.085 μM.	Research Square, 2024, 10.21203/rs.3.rs-3480364/v1 J Cell Biochem, 2022, 10.1002/jcb.30231 Front Neurosci, 2021, 15:741214
S2026	Ginkgolide A	Ginkgolide A (BN52020) is an extract from in Ginkgo biloba and a g-aminobutyric acid (GABA) antagonist with a Ki of 14.5 μM.	Cell Rep, 2020, 21;31(3):107521
S5194	Furosemide sodium	Furosemide (Frusemide) sodium is a potent and orally active inhibitor of Na-K-Cl cotransporter (NKCC). Furosemide sodium is a subtype-selective antagonist of gamma-aminobutyric acid type A (GABAA) receptor.	Nat Commun, 2024, 15(1):7342 Ren Fail, 2022, 44(1):1345-1355
S9249	Securinine	Securinine, a major natural alkaloid product from the root of the plant Securinega suffruticosa, acts as a γ-amino butyric acid (GABA) receptor antagonist.
S4587	Pentylenetetrazol	Pentylenetetrazol (Pentylenetetrazole, Metrazole, pentetrazol, pentamethylenetetrazol, Corazol, Cardiazol, PTZ) displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GABA(A) receptor antagonist.	Cell Mol Life Sci, 2024, 81(1):104
S6008	p-Hydroxybenzaldehyde	p-Hydroxybenzaldehyde (4-Hydroxybenzaldehyde, 4-Formylphenol, p-Formylphenol), which can be found in the orchids Gastrodia elata, Galeola faberi and vanilla, is a hydroxybenzaldehyde that reacts with NAD+ and H2O to produce 4-hydroxybenzoate, NADH, and 2 protons.
S9065	Songorine	Songorine, a ubiquitous alkaloid in the genus Aconitum, is a novel antagonist of the GABAA receptor in rat brain and has antiarrhythmic, antinociceptive, anti-inflammatory, regenerative and CNS-modulating properties.
S4197	Bemegride	Bemegride(Bemegrid,3-Ethyl-3-methylglutarimide) is a central nervous system stimulant and antidote for barbiturate poisoning.
S5049	Thiocolchicoside	Thiocolchicoside (Thiocolchicine 2-glucoside analog, Coltramyl) is a natural occuring glycoside originated from the flower seeds of superba gloriosa with anti-inflammatory and analgesic properties as well as pronounced convulsant activity. It is also an antagonist of GABAA receptor.
S6094	Imidazole-4(5)-acetic Acid Hydrochloride	Imidazole-4(5)-acetic Acid Hydrochloride is a competitive antagonist at GABAC receptors.
S6100	Picrotoxin	Picrotoxin (Picrotin, Cocculin, Cocculus, NSC 403139), a plant alkaloid, is a non-competitive antagonist of neuronal GABA and glycine receptors.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing.
S9176	Pimpinellin	Pimpinellin is a furocoumarin that acts as antagonist of proteins with GABA receptor activity.
S2399	Dihydromyricetin	Dihydromyricetin (Ampelopsin, Ampeloptin) is a natural antioxidant flavonoid from Ampelopsis grossedentata.	Front Pharmacol, 2022, 13:932092 Molecules, 2021, 26(5)1210 Cell Signal, 2020, 65:109431
S2133	Gabapentin	Gabapentin is a GABA analogue, used to treat seizures and neuropathic pain.	Mol Oncol, 2022, 10.1002/1878-0261.13281 Mol Pharmacol, 2022, 101(4):236-245 Cell Death Dis, 2020, 11(9):764
S1338	Gabapentin HCl	Gabapentin HCl(Neurontin HCl) is a GABA analogue, used to treat seizures and neuropathic pain.	Mol Pharmacol, 2022, 101(4):236-245 Int J Clin Exp Pathol, 2018, 11(12):5536-5546 J Aging Sci, 2017, 5:1
S3072	(R)-baclofen	(R)-baclofen (STX 209) is a derivative of gamma-aminobutyric acid primarily used to treat spasticity.	J Cell Biochem, 2022, 10.1002/jcb.30231
S3786	Glabridin	Glabridin (Q-100692, KB-289522, LS-176045), one of the active phytochemicals in licorice extract, binds to and activates the ligand binding domain of PPARγ, as well as the full length receptor. It is also a GABAA receptor positive modulator promoting fatty acid oxidation and improving learning and memory.	Life Sci, 2021, S0024-3205(20)31752-5
S4700	4-Aminobutyric acid (GABA)	4-Aminobutyric acid (4-Aminobutanoic acid, GABA, Gamma-aminobutyric acid, Piperidic acid) is a naturally occurring neurotransmitter with central nervous system (CNS) inhibitory activity.	Theranostics, 2023, 13(4):1355-1369
S4840	Baclofen	Baclofen is a gamma-amino-butyric acid (GABA) derivative used as a skeletal muscle relaxant and central nervous system depressant. It activates GABA receptors, specifically the GABAB receptors.
S3634	6-Hydroxyflavone (6-HF)	6-Hydroxyflavone, a naturally occurring flavonoid, binds to GABAA receptors with moderate affinity and acts as a partial agonist of GABAA receptors.
S4892	Phenibut	Phenibut (Aminophenylbutyric acid, Fenibut, Phenigam, Phenybut, PhGABA, β-Phenyl-γ-aminobutyric acid, β-Phenyl-GABA), a GABA analogue, is a central nervous system depressant with anxiolytic and sedative effects.
S4961	3,4,5-Trimethoxycinnamic acid	3,4,5-Trimethoxycinnamic acid (TMCA) is one of the constituents of Polygalae Radix and may exert anti-seizure activity by acting at the GABAA/BZ receptor complex.
E4920New	Baclofen hydrochloride	Baclofen hydrochloride is an agonist of the GABAB receptor that mimics the action of GABA, leading to slow presynaptic inhibition via the GABAB receptor. It improves the function of the ubiquitin-proteasome system (UPS) and enhances cell survival in both in vitro and in vivo models of Huntington's disease (HD).
S3663	Afloqualone	Afloqualone (AFQ, HQ-495) is a quinazolinone family GABAergic drug with muscle-relaxant and sedative effects, showing the agonist activity at the β subtype of the GABAa receptor.
S4270	Oxiracetam	Oxiracetam (ISF 2522), a cyclic derivative of gamma-aminobutyric acid (GABA), is used as a nootropic drug to improve memory and learning.	Eur J Pharmacol, 2024, 979:176835
S3748	Acamprosate Calcium	Acamprosate (N-Acetylhomotaurine, Calcium acetylhomotaurinate,N-acetylhomotaurinate) is a synthetic compound with a chemical structure similar to the amino acid neurotransmitter gamma-aminobutyric acid (GABA) and the amino acid neuromodulator taurine.
S5612	Isonipecotic acid	Isonipecotic acid (4-Piperidinecarboxylic acid, 4-Carboxypiperidine, Hexahydroisonicotinic acid) is a heterocyclic compound that mainly acts as a GABAA receptor partial agonist.
S6611	Cyclothiazide	Cyclothiazide is a positive allosteric modulator of ionotropic α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)-type glutamate receptors with critical roles in neurological development and function.	Nucleic Acids Res, 2024, gkae761 J Immunother Cancer, 2024, 12(11)e009805 Adv Sci (Weinh), 2023, 10(3):e2203718
S5131	Homotaurine	Homotaurine (Tramiprosate, Alzhemed, 3-Amino-1-propanesulfonic acid) is a synthetic organic compound that has GABAergic activity by mimicking GABA. It is a GABAA partial agonist as well as a GABAB receptor partial agonist with low efficacy.
S3959	(+)-Borneol	(+)-Borneol is one of enantiomers of borneol which is a valuable medical material, senior aromatic spice, and chemical material and has been used in food and also folk medicine.
S0049	Zuranolone (SAGE-217)	Zuranolone(SAGE-217, CS-2797) is an orally active and potent neuroactive steroid and positive allosteric modulator of the GABAA receptor, with EC50s of 296 nM for α1β2γ2 receptor.
S5596	(1S)-(-)-α-Pinene	α-Pinene is found in the oils of many species of many coniferous trees, notably the pine and has insecticidal activity.
S5805	Allopregnanolone	Allopregnanolone, a neurosteroid synthesized from progesterone in brain, acts as a highly potent positive allosteric modulator of the GABAA receptor.
E0101	AZD6280	AZD6280 is a selective GABAA (α2/3) receptor modulator, used for treatment of generalized anxiety disorder.
S0164	AZD7325	AZD7325 is a potent and orally active partial selective Positive allosteric modulator (PAM) of GABAAα2 and Aα3 receptor with Ki=0.3 and 1.3 nM, respectively, and has less antagonistic efficacy at the Aα1 and Aα5 receptor subtypes.
S9409	Kavain	Kavain, the main kavalactone found mostly in the roots of the kava plant, has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na+ and Ca2+ channels.
S3977	(-)-Borneol	(-)-Borneol (L-Borneol), one of enantiomers of borneol, has a camphoraceous and evident woody odor.
S6755	NS 11394	NS11394 is a subtype-selective positive allosteric modulator at GABAA receptors, with selectivity for the α3 and α5 subtypes.
E0960	RO5186582	RO5186582 (Basmisanil, RG1662) is a highly selective GABAAα5 negative allosteric modulator.
E4920New	Baclofen hydrochloride	Baclofen hydrochloride is an agonist of the GABAB receptor that mimics the action of GABA, leading to slow presynaptic inhibition via the GABAB receptor. It improves the function of the ubiquitin-proteasome system (UPS) and enhances cell survival in both in vitro and in vivo models of Huntington's disease (HD).
E4920New	Baclofen hydrochloride	Baclofen hydrochloride is an agonist of the GABAB receptor that mimics the action of GABA, leading to slow presynaptic inhibition via the GABAB receptor. It improves the function of the ubiquitin-proteasome system (UPS) and enhances cell survival in both in vitro and in vivo models of Huntington's disease (HD).