DPP

亜型選択性的な製品

DPP-2 DPP-4 DPP-8 DPP-9

シグナル伝達経路

DPP製品

All (20)
DPP阻害剤 (19)
DPP抗体(1)
新製品

製品コード	製品名称	製品説明	文献中Selleckの製品使用例
S5079	Sitagliptin	Sitagliptin (MK-0431) is an oral and highly selective DPP-4 inhibitor with an IC50 of 18 nM. It is used for the treatment of type 2 diabetes.	J Neuroinflammation, 2024, 21(1):312 Antioxidants (Basel), 2024, 13(9)1083 OPARU, 2024, 10.18725/OPARU-52005
S3033	Vildagliptin	Vildagliptin inhibits DPP−4 with IC50 of 2.3 nM.	Int J Mol Sci, 2024, 25(18)9760 J Clin Invest, 2023, 133(12)e165933 Oncoimmunology, 2023, 12(1):2268257
S4002	Sitagliptin phosphate monohydrate	Sitagliptin phosphate monohydrate (MK-0431) is a potent inhibitor of DPP-IV with IC50 of 19 nM in Caco-2 cell extracts.	Front Oncol, 2021, 11:704024 J Biomol Struct Dyn, 2021, 1-12 J Diabetes Res, 2020, 2020:2450781
S1540	Saxagliptin (BMS-477118)	Saxagliptin (BMS-477118, Onglyza) is a selective and reversible DPP4 inhibitor with IC50 of 26 nM.	Turk J Pharm Sci, 2019, 16(2):227-233 Cancer Cell, 2018, 34(4):659-673 J Chromatogr B Analyt Technol Biomed Life Sci, 2018, 1083:249-257
S8455	Talabostat (PT-100)	Talabostat (Val-boroPro, PT-100) is a dipeptidyl peptidase inhibitor with IC50 values of <4 nM, 4 nM, 11 nM, 310 nM, 560 nM and 390 nM for DPP-IV, DPP8, DPP9, QPP, FAP and PEP respectively. It has antineoplastic and hematopoiesis- stimulating activities.	J Oral Microbiol, 2024, 16(1):2373040 Brain Res, 2024, S0006-8993(24)00383-4 Nat Chem Biol, 2023, 19(4):431-439
S8565	Omarigliptin (MK-3102)	Omarigliptin (MK-3102) is a competitive, reversible inhibitor of DPP-4 (IC50 = 1.6 nM, Ki = 0.8 nM). It is highly selective over all proteases tested (IC50 > 67 μM), including QPP, FAP, PEP, DPP8, and DPP9 and has weak ion channel activity (IC50 > 30 μM at IKr, Caγ1.2, and Naγ1.5).	NYMC Student Theses and Dissertations, 2023, Acta Pharmacol Sin, 2021, 1-9 Front Behav Neurosci, 2021, 15:705579
S2868	Alogliptin (SYR-322) benzoate	Alogliptin (SYR-322) benzoate is a potent, selective inhibitor of DPP-4 with IC50 of <10 nM, exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9.	Cell Rep, 2017, 20(7):1692-1704
S5365	Alogliptin	Alogliptin is a potent, selective inhibitor of the serine protease dipeptidyl peptidase IV (DPP-4)with IC50 values of 2.63 nM and exhibits greater than 10,000 fold selectivity over the closely related serine proteases DPP-8 and DPP-9.	Sci Adv, 2021, 7(27)eabh3032
S4697	Saxagliptin hydrate	Saxagliptin H2O (BMS-477118, Onglyza) is a selective and reversible DPP4 inhibitor with IC50 of 26 nM.	Turk J Pharm Sci, 2019, 16(2):227-233
E4814^New	Teneligliptin Hydrobromide Hydrate	Teneligliptin Hydrobromide Hydrate(MP-513 hydrobromide hydrate) is a potent, competitive, and long-lasting inhibitor of DPP-4. It competitively inhibited rhDPP-4, human plasma, and rat plasma with IC50 values of 0.889, 1.75, and 1.35 nM respectively. It suppresses high glucose-mediated mitochondrial dysfunction and can be used for treatment of type 2 diabetes.
E1188^New	Brensocatib	Brensocatib (AZD7986, INS1007) is an oral, selective, reversible inhibitor of dipeptidyl peptidase-1 (DPP-1). It reduces the activity of all major neutrophil serine proteases (NSPs) including, neutrophil elastase (NE), proteinase 3 (PR3), and cathepsin G (CatG) in patients with bronchiectasis.	Nat Commun, 2024, 15(1):6519
E4804^New	Sitagliptin phosphate	Sitagliptin phosphate (MK-0431 phosphate) is a potent inhibitor of dipeptidyl peptidase IV (DPP-4) with an IC50 value of 19 nM in Caco-2 cell extracts.
S9631	Puromycin aminonucleoside	Puromycin aminonucleoside (NSC 3056, PAN, Stylomycin aminonucleoside, ARDMA, SAN), the aminonucleoside portion of the antibiotic puromycin, is a reversible inhibitor of dipeptidyl-peptidase II and cytosol alanyl aminopeptidase that induces apoptosis in mesangial cells (MCs) accompanied by declined cell viability and enhanced inflammatory response.Puromycin aminonucleoside can be used to induce animal models of Kidney Disease.	Cell Mol Biol Lett, 2023, 28(1):62 Cell Mol Biol Lett, 2023, 28(1):62 Oral Dis, 2022, 10.1111/odi.14321
S5909	Anagliptin	Anagliptin is an orally active and highly selective dipeptidyl peptidase-4 (DPP-4) inhibitor and exerts anti-inflammatory effects on macrophages, adipocytes, and mouse livers by suppressing NF-κB activation.
E4916^New	Bestatin hydrochloride	Bestatin hydrochloride is an inhibitor of aminopeptidase N and enkephalinase that elevates the levels of angiotensin II and angiotensin III. It also acts as a non-competitive inhibitor (α > 1) of porcine DPP-IV with a Ki value of 75 μM. It reduces DPP-IV activity, decreases cell viability, and increases DNA fragmentation in vitro. It has the potential to treat skin conditions like acne, psoriasis and keloids.
A2517	Begelomab (Anti-DPP4 / CD26)	Begelomab (Anti-DPP4 / CD26) is a murine IgG2b monoclonal antibody targeting DPP-4/CD26. Begelomab can be used for the research of severe refractory idiopathic inflammatory myopathy. MW: 145.5 KD.
S7513	Trelagliptin	Trelagliptin (SYR-472), a potent, orally active and highly selective DPP-4 inhibitor with an IC50 of 4 nM, improves glycemic control in vivo and can be used for the study of type 2 diabetes mellitus (T2DM).
E6005^New	Saxagliptin hydrochloride	Saxagliptin hydrochloride (BMS-477118 hydrochloride) is a potent, selective, reversible, competitive, and orally active inhibitor of dipeptidyl peptidase-4 (DPP-4). It exhibits 400-950 fold selective inhibition of DPP-4 than DPP-8. Saxagliptin hydrochloride is used in the research of type 2 diabetes mellitus research.
S5063	Trelagliptin succinate	Trelagliptin succinate (SYR472) is a dipeptidyl peptidase IV (DPP-4) inhibitor which is used as a new long-acting drug for once-weekly treatment of type 2 diabetes mellitus (DM).
E0122	Gemigliptin	Gemigliptin (Zemiglo, LC15-0444) is a potent, selective and long-acting dipeptidyl peptidase 4 (DPP 4) inhibitor with a Ki of 7.25 nM. Gemigliptin shows at least >23,000-fold selectivity for DPP-4 over various proteases and peptidases, including DPP-8, DPP-9, and fibroblast activation protein (FAP)-α.
S5079	Sitagliptin	Sitagliptin (MK-0431) is an oral and highly selective DPP-4 inhibitor with an IC50 of 18 nM. It is used for the treatment of type 2 diabetes.	J Neuroinflammation, 2024, 21(1):312 Antioxidants (Basel), 2024, 13(9)1083 OPARU, 2024, 10.18725/OPARU-52005
S3033	Vildagliptin	Vildagliptin inhibits DPP−4 with IC50 of 2.3 nM.	Int J Mol Sci, 2024, 25(18)9760 J Clin Invest, 2023, 133(12)e165933 Oncoimmunology, 2023, 12(1):2268257
S4002	Sitagliptin phosphate monohydrate	Sitagliptin phosphate monohydrate (MK-0431) is a potent inhibitor of DPP-IV with IC50 of 19 nM in Caco-2 cell extracts.	Front Oncol, 2021, 11:704024 J Biomol Struct Dyn, 2021, 1-12 J Diabetes Res, 2020, 2020:2450781
S1540	Saxagliptin (BMS-477118)	Saxagliptin (BMS-477118, Onglyza) is a selective and reversible DPP4 inhibitor with IC50 of 26 nM.	Turk J Pharm Sci, 2019, 16(2):227-233 Cancer Cell, 2018, 34(4):659-673 J Chromatogr B Analyt Technol Biomed Life Sci, 2018, 1083:249-257
S8455	Talabostat (PT-100)	Talabostat (Val-boroPro, PT-100) is a dipeptidyl peptidase inhibitor with IC50 values of <4 nM, 4 nM, 11 nM, 310 nM, 560 nM and 390 nM for DPP-IV, DPP8, DPP9, QPP, FAP and PEP respectively. It has antineoplastic and hematopoiesis- stimulating activities.	J Oral Microbiol, 2024, 16(1):2373040 Brain Res, 2024, S0006-8993(24)00383-4 Nat Chem Biol, 2023, 19(4):431-439
S8565	Omarigliptin (MK-3102)	Omarigliptin (MK-3102) is a competitive, reversible inhibitor of DPP-4 (IC50 = 1.6 nM, Ki = 0.8 nM). It is highly selective over all proteases tested (IC50 > 67 μM), including QPP, FAP, PEP, DPP8, and DPP9 and has weak ion channel activity (IC50 > 30 μM at IKr, Caγ1.2, and Naγ1.5).	NYMC Student Theses and Dissertations, 2023, Acta Pharmacol Sin, 2021, 1-9 Front Behav Neurosci, 2021, 15:705579
S2868	Alogliptin (SYR-322) benzoate	Alogliptin (SYR-322) benzoate is a potent, selective inhibitor of DPP-4 with IC50 of <10 nM, exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9.	Cell Rep, 2017, 20(7):1692-1704
S5365	Alogliptin	Alogliptin is a potent, selective inhibitor of the serine protease dipeptidyl peptidase IV (DPP-4)with IC50 values of 2.63 nM and exhibits greater than 10,000 fold selectivity over the closely related serine proteases DPP-8 and DPP-9.	Sci Adv, 2021, 7(27)eabh3032
S4697	Saxagliptin hydrate	Saxagliptin H2O (BMS-477118, Onglyza) is a selective and reversible DPP4 inhibitor with IC50 of 26 nM.	Turk J Pharm Sci, 2019, 16(2):227-233
E4814^New	Teneligliptin Hydrobromide Hydrate	Teneligliptin Hydrobromide Hydrate(MP-513 hydrobromide hydrate) is a potent, competitive, and long-lasting inhibitor of DPP-4. It competitively inhibited rhDPP-4, human plasma, and rat plasma with IC50 values of 0.889, 1.75, and 1.35 nM respectively. It suppresses high glucose-mediated mitochondrial dysfunction and can be used for treatment of type 2 diabetes.
E1188^New	Brensocatib	Brensocatib (AZD7986, INS1007) is an oral, selective, reversible inhibitor of dipeptidyl peptidase-1 (DPP-1). It reduces the activity of all major neutrophil serine proteases (NSPs) including, neutrophil elastase (NE), proteinase 3 (PR3), and cathepsin G (CatG) in patients with bronchiectasis.	Nat Commun, 2024, 15(1):6519
E4804^New	Sitagliptin phosphate	Sitagliptin phosphate (MK-0431 phosphate) is a potent inhibitor of dipeptidyl peptidase IV (DPP-4) with an IC50 value of 19 nM in Caco-2 cell extracts.
S9631	Puromycin aminonucleoside	Puromycin aminonucleoside (NSC 3056, PAN, Stylomycin aminonucleoside, ARDMA, SAN), the aminonucleoside portion of the antibiotic puromycin, is a reversible inhibitor of dipeptidyl-peptidase II and cytosol alanyl aminopeptidase that induces apoptosis in mesangial cells (MCs) accompanied by declined cell viability and enhanced inflammatory response.Puromycin aminonucleoside can be used to induce animal models of Kidney Disease.	Cell Mol Biol Lett, 2023, 28(1):62 Cell Mol Biol Lett, 2023, 28(1):62 Oral Dis, 2022, 10.1111/odi.14321
S5909	Anagliptin	Anagliptin is an orally active and highly selective dipeptidyl peptidase-4 (DPP-4) inhibitor and exerts anti-inflammatory effects on macrophages, adipocytes, and mouse livers by suppressing NF-κB activation.
E4916^New	Bestatin hydrochloride	Bestatin hydrochloride is an inhibitor of aminopeptidase N and enkephalinase that elevates the levels of angiotensin II and angiotensin III. It also acts as a non-competitive inhibitor (α > 1) of porcine DPP-IV with a Ki value of 75 μM. It reduces DPP-IV activity, decreases cell viability, and increases DNA fragmentation in vitro. It has the potential to treat skin conditions like acne, psoriasis and keloids.
S7513	Trelagliptin	Trelagliptin (SYR-472), a potent, orally active and highly selective DPP-4 inhibitor with an IC50 of 4 nM, improves glycemic control in vivo and can be used for the study of type 2 diabetes mellitus (T2DM).
E6005^New	Saxagliptin hydrochloride	Saxagliptin hydrochloride (BMS-477118 hydrochloride) is a potent, selective, reversible, competitive, and orally active inhibitor of dipeptidyl peptidase-4 (DPP-4). It exhibits 400-950 fold selective inhibition of DPP-4 than DPP-8. Saxagliptin hydrochloride is used in the research of type 2 diabetes mellitus research.
S5063	Trelagliptin succinate	Trelagliptin succinate (SYR472) is a dipeptidyl peptidase IV (DPP-4) inhibitor which is used as a new long-acting drug for once-weekly treatment of type 2 diabetes mellitus (DM).
E0122	Gemigliptin	Gemigliptin (Zemiglo, LC15-0444) is a potent, selective and long-acting dipeptidyl peptidase 4 (DPP 4) inhibitor with a Ki of 7.25 nM. Gemigliptin shows at least >23,000-fold selectivity for DPP-4 over various proteases and peptidases, including DPP-8, DPP-9, and fibroblast activation protein (FAP)-α.
A2517	Begelomab (Anti-DPP4 / CD26)	Begelomab (Anti-DPP4 / CD26) is a murine IgG2b monoclonal antibody targeting DPP-4/CD26. Begelomab can be used for the research of severe refractory idiopathic inflammatory myopathy. MW: 145.5 KD.
E4814^New	Teneligliptin Hydrobromide Hydrate	Teneligliptin Hydrobromide Hydrate(MP-513 hydrobromide hydrate) is a potent, competitive, and long-lasting inhibitor of DPP-4. It competitively inhibited rhDPP-4, human plasma, and rat plasma with IC50 values of 0.889, 1.75, and 1.35 nM respectively. It suppresses high glucose-mediated mitochondrial dysfunction and can be used for treatment of type 2 diabetes.
E1188^New	Brensocatib	Brensocatib (AZD7986, INS1007) is an oral, selective, reversible inhibitor of dipeptidyl peptidase-1 (DPP-1). It reduces the activity of all major neutrophil serine proteases (NSPs) including, neutrophil elastase (NE), proteinase 3 (PR3), and cathepsin G (CatG) in patients with bronchiectasis.	Nat Commun, 2024, 15(1):6519
E4804^New	Sitagliptin phosphate	Sitagliptin phosphate (MK-0431 phosphate) is a potent inhibitor of dipeptidyl peptidase IV (DPP-4) with an IC50 value of 19 nM in Caco-2 cell extracts.
E4916^New	Bestatin hydrochloride	Bestatin hydrochloride is an inhibitor of aminopeptidase N and enkephalinase that elevates the levels of angiotensin II and angiotensin III. It also acts as a non-competitive inhibitor (α > 1) of porcine DPP-IV with a Ki value of 75 μM. It reduces DPP-IV activity, decreases cell viability, and increases DNA fragmentation in vitro. It has the potential to treat skin conditions like acne, psoriasis and keloids.
E6005^New	Saxagliptin hydrochloride	Saxagliptin hydrochloride (BMS-477118 hydrochloride) is a potent, selective, reversible, competitive, and orally active inhibitor of dipeptidyl peptidase-4 (DPP-4). It exhibits 400-950 fold selective inhibition of DPP-4 than DPP-8. Saxagliptin hydrochloride is used in the research of type 2 diabetes mellitus research.

DPP阻害剤の選択性比較