Antiviral

Antiviral製品

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Antiviral阻害剤 (30)
Antiviralモジュレータ(1)
新製品

製品コード	製品名称	製品説明	文献中Selleckの製品使用例
S1102	U0126-EtOH	U0126-EtOH is a highly selective inhibitor of MEK1/2 with IC50 of 0.07 μM/0.06 μM in cell-free assays, 100-fold higher affinity for ΔN3-S218E/S222D MEK than PD98059. U0126 inhibits autophagy and mitophagy with antiviral activity.	MedComm (2020), 2024, 5(5):e525 Int J Biol Sci, 2024, 20(6):2202-2218 Cell Death Dis, 2024, 15(1):31
S1623	Acetylcysteine (N-acetylcysteine)	Acetylcysteine (N-acetyl-l-cysteine, NAC,N-acetylcysteine) is a ROS(reactive oxygen species) inhibitor that antagonizes the activity of proteasome inhibitors. It is also a tumor necrosis factor production inhibitor. Acetylcysteine(N-acetyl-l-cysteine) suppresses TNF-induced NF-κB activation through inhibition of IκB kinases. Acetylcysteine(N-acetyl-l-cysteine) induces apoptosis via the mitochondria-dependent pathway. Acetylcysteine(N-acetyl-l-cysteine) inhibits ferroptosis and virus replication.Solutions are unstable and should be fresh-prepared.	Mol Cancer, 2024, 23(1):240 Nat Commun, 2024, 15(1):4124 Nat Commun, 2024, 15(1):4124
S8932	Remdesivir (GS-5734)	Remdesivir (GS-5734), a monophosphoramidate prodrug of an adenosine analog, is an investigational broad-spectrum antiviral agent with in vitro activity against multiple RNA viruses, including Ebola and CoV.	Antiviral Res, 2024, 225:105840 Int J Mol Sci, 2024, 24;25(3):1427. Int J Mol Sci, 2024, 25(3)1427
S7775	Emricasan (IDN-6556)	Emricasan (IDN-6556, PF 03491390, PF-03491390) is a potent irreversible pan-caspase inhibitor. Emricasan is an inhibitor of Zika virus infection.	Immunity, 2024, S1074-7613(24)00221-8 Acta Neuropathol, 2024, 147(1):56 Cell Death Differ, 2024, 31(7):938-953
S1537	Vadimezan (DMXAA)	Vadimezan (DMXAA) is a vascular disrupting agents (VDA) and competitive inhibitor of DT-diaphorase with Ki of 20 μM and IC50 of 62.5 μM in cell-free assays, respectively. DMXAA (Vadimezan) is also a STING agonist with potential antineoplastic activity. DMXAA (Vadimezan) potently induces IFN-β but relatively low TNF-α expression in vitro. DMXAA (Vadimezan) has antiviral activity. Phase 3.	Mol Cancer, 2024, 23(1):186 Nat Commun, 2024, 15(1):1750 Cell Rep Med, 2024, 5(7):101648
S2239	Tubacin	Tubacin is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor with an IC50 of 4 nM in a cell-free assay, approximately 350-fold selectivity over HDAC1. Tubacin reduces the replication of the Japanese Encephalitis Virus via the decrease of viral RNA synthesis.	Dev Cell, 2024, S1534-5807(24)00326-5 Br J Cancer, 2023, 10.1038/s41416-023-02195-0 Int J Mol Sci, 2023, 24(5)4720
S2713	Geldanamycin	Geldanamycin is a natural existing HSP90 inhibitor with K_d of 1.2 μM, specifically disrupts glucocorticoid receptor (GR)/HSP association. Geldanamycin attenuates virus infection-induced ALI (acute lung injury)/ARDS (acute respiratory distress syndrome) by reducing the host's inflammatory responses.	Nat Commun, 2024, 15(1):9448 Cell Rep, 2024, 43(10):114827 Int J Mol Sci, 2023, 24(18)13830
S1401	Tenofovir	Tenofovir (GS-1278) blocks reverse transcriptase and hepatitis B virus infections.	J Biomed Sci, 2024, 31(1):34 Hepatol Commun, 2024, 8(1)e0351 Nat Commun, 2023, 14(1):199
S2504	Ribavirin (ICN-1229)	Ribavirin (NSC-163039, ICN-1229, RTCA, Tribavirin), a synthetic guanosine analogue, possesses a broad spectrum of activity against DNA and RNA viruses.	Nat Commun, 2024, 15(1):9461 Cell, 2023, 186(14):3033-3048.e20 Antimicrob Agents Chemother, 2023, 67(7):e0046223
S1807	Acyclovir (Aciclovir)	Acyclovir (Aciclovir) is a synthetic nucleoside analogue active against herpesviruses. Acyclovir induces cell cycle perturbation and apoptosis in Jurkat leukemia cells.	Nat Commun, 2024, 15(1):9461 Cell, 2023, 186(14):3033-3048.e20 iScience, 2022, 25(12):105682
S8071	UNC0638	UNC0638 is a potent, selective and cell-penetrant chemical probe for G9a and GLP histone methyltransferase with IC50 of <15 nM and 19 nM, respectively, shows selectivity over a wide range of epigenetic and non-epigenetic targets. UNC0638 has anti-viral activities.	Cell Rep, 2024, 43(2):113779 Cell Rep, 2023, 42(6):112566 Genome Instability & Disease , 2023, 4:21–37
S2467	Famciclovir	Famciclovir (BRL-42810) is a guanine analogue antiviral drug used for the treatment of various herpesvirus infections.	J Pers Med, 2022, 12(2)258 Eur J Pharm Biopharm, 2022, S0939-6411(22)00047-9 Hum Cell, 2022, 10.1007/s13577-022-00671-y
S2486	Moroxydine HCl	Moroxydine HCl(ABOB hydrochloride) is a synthetic antiviral compound chemically belonging to the series of the heterocyclic biguanidines.	J Pers Med, 2022, 12(2)258 Hum Cell, 2022, 10.1007/s13577-022-00671-y Biomedicines, 2021, 9(8)996
S2420	Aloperine	Aloperine is an isolated alkaloid in sophora plants such as Sophora alopecuroides L, and exhibits anti-inflammatory, antibacterial, antiviral, and anti-tumor properties.	Cancer Cell Int, 2021, 21(1):662 Tissue Cell, 2021, 74:101706 J Cancer Res Clin Oncol, 2020, 10.1007/s00432-020-03157-2
S4184	Penciclovir	Penciclovir (BRL-39123, VSA 671,NSC-759624) is a purine acyclic nucleoside analogue with potent antiviral activity.	Eur J Pharm Biopharm, 2022, S0939-6411(22)00047-9 Antiviral Res, 2021, S0166-3542(21)00068-1 ACS Infect Dis, 2021, 10.1021/acsinfecdis.1c00083
S6814	GS-441524	GS-441524, a molecular precursor to a pharmacologically active nucleoside triphosphate molecule, is a potent inhibitor of feline infectious peritonitis virus (FIPV) with EC50 of 0.78 μM.	Infect Drug Resist, 2024, 17:531-541 Commun Biol, 2023, 6(1):511 EBioMedicine, 2022, 81:104095
S2334	Oleanolic Acid	Oleanolic Acid (Caryophyllin) is a non-toxic, hepatoprotective triterpenoid found in Phytolacca Americana, which exerts antitumor and antiviral properties.	Front Pharmacol, 2021, 12:697483 J Cell Sci, 2021, 134(8)jcs255273 J Asian Nat Prod Res, 2019, 21(6):522-527
S4879	Tenofovir hydrate	Tenofovir (GS-1278) hydrate blocks reverse transcriptase and hepatitis B virus infections.	Cancer Discov, 2022, candisc.1117.2021 Cells, 2020, 9(4)E1003
S8750	NGI-1	NGI-1 is an aminobenzamide-sulfonamide compound that targets both oligosaccharyltransferase (OST) isoforms and therefore may exhibit antiviral activity against flaviviruses.	Int J Mol Sci, 2024, 25(5)2768 Cancer Discov, 2023, 13(8):1862-1883 J Cell Biochem, 2022, 10.1002/jcb.30204
E0153	Lithium Chloride	Lithium Chloride (LiCl) inhibits the replication of type 1 and type 2 Herpes simplex virus at concentrations which permitted host cell replication. Lithium chloride also prevents glucocorticoid-induced osteonecrosis of femoral heads and strengthens mesenchymal stem cell activity in rats.	Mol Med Rep, 2025, 31(1)30 Mil Med Res, 2024, 11(1):27 Cell Death Dis, 2024, 15(5):332
S5684	Lapachol	Lapachol (Tecomin, CI75490, Bethabarra wood, Greenhartin), a natural compound isolated from the bark of the lapacho tree, shows both antimicrobial and antiviral activity.	Elife, 2020, 9e56773 Elife, 2020, 9e56773
S9303	Saikosaponin B2	Saikosaponin B2 is a naturally occurring terpenoid that efficiently inhibits hepatitis C virus entry.	Phytomedicine, 2019, 67:153163
S9063	Harringtonine	Harringtonine is a natural cephalotaxine alkaloid that inhibits protein biosynthesis. It also exhibits antiviral and anticancer activities.	BioRxiv, 2022, 10.1101/2021.04.12.439420 BioRxiv, 2021, PPR: PPR311141 Research Square, 2021, 10.21203/rs.3.rs-541829/v1
S9669	U18666A	U18666A (U18) is an inhibitor of intra-cellular cholesterol transport that inhibits dengue virus entry and replication.	Redox Biol, 2023, 63:102732
S6289	Gentamicin	Gentamicin, an aminoglycoside class of bactericidal antibiotic, is effective against gram-negative bacterial infections.	Universitätsmedizin Berlin, 2021, 10.17169/refubium-29871
S1637	Docosanol	Docosanol is a saturated fatty alcoholused traditionally as an emollient, emulsifier, and thickener in cosmetics, nutritional supplement. (ED50=2.5 mg/mL for plaque inhibition, and ED50=1.7 mg/mL for inhibition of virus production)
S1883	Idoxuridine	Idoxuridine (NSC 39661, SKF 14287,5-Iodo-2′-deoxyuridine,5-IUdR,IdUrd) is an antiviral agent for feline herpesvirus type-1 with IC50 of 4.3 μM.
E0150	Carrageenan	Carrageenan (kappa-Carrageenan) is a natural carbohydrate (polysaccharide) obtained from edible red seaweeds. Carrageenan shows anticoagulant activity, antithrombotic activity, antiviral activity, anti-tumour activity and immunomodulatory activity.
S3251	Goitrin	Goitrin (DL-Goitrin, (R, S)-Goitrin, R,S-goitrin) is one of the main constituent of Radix isatidis (Banlangen) which is widely used as a traditional Chinese medicine for treating fever and removing toxic heat. Goitrin exhibits antiviral and antiendotoxin activity.
S5554	Lanatoside C	Lanatoside C is a cardiac glycoside with antiviral and anti-tumor activity. Lanatoside C induces G2/M cell cycle arrest and induces autophagy and apoptosis via attenuating MAPK, Wnt, JAK-STAT, and PI3K/AKT/mTOR signaling pathways.
S0936	Aloin B	Aloin B (Isobarbaloin), isolated from Aloe vera, is one isomer of Aloin and has anti-hepatitis B virus (HBV) acyivity.	Nan Fang Yi Ke Da Xue Xue Bao, 2023, 43(5):702-709
S9224	Dehydroandrographolide Succinate	Dehydroandrographolide succinate (DAS), extracted from herbal medicine Andrographis paniculata (Burm f) Nees, has antibacterial and antiviral effects.
S3380	Tecovirimat	Tecovirimat is an antiviral that inhibits the egress of orthopoxviruses by targeting viral p37 protein orthologs. Tecovirimat is developed for the treatment of smallpox infection.	Microbiol Spectr, 2024, e0358623.
E0365	Fucoidan	Fucoidan is an anionic sulfated polysaccharide extracted from marine brown algae with a large range of biological activities, including anti-inflammatory, anti-cancer, anti-viral, anti-oxidation, anticoagulant, antithrombotic, anti-angiogenic and anti-Helicobacter pylori, etc.	Int J Biol Macromol, 2024, 276(Pt 1):133792
E2027	LL-37 acetate	LL-37 acetate is a 37-residue, amphipathic, cathelicidin-derived peptide, which exhibits a broad spectrum of antimicrobial activity.
S9278	Saikosaponin C	Saikosaponin C is a triterpene saponin found in Bupleurum that exhibits antiviral and pro-angiogenic activities.
E0336	CBS1117	CBS1117 is a virus entry inhibitor with an IC50 of 70 nM for influenza A virus, A/Puerto Rico/8/34 (H1N1), also interferes with the hemagglutinin (HA)-mediated fusion process.
E0010	Hypocrellin A	Hypocrellin A (HA) is a perylenequinone isolated from Shiraia bambusicola that shows antiviral, antimicrobial and anticancer activity through mediating multiple signaling pathways. Hypocrellin A also is a selective and potent inhibitor of PKC.
S4942	4-Hydroxy-3,5-dimethoxybenzyl alcohol	4-Hydroxy-3,5-dimethoxybenzyl alcohol (Syringic alcohol, Syringyl alcohol) is a kind of phenol with antiviral properties.
S6867	Glyceryl monocaprate (Monocaprin)	Monocaprin (Glyceryl caprate) is a 1-monoglyceride of capric acid that has antimicrobial activity against enveloped viruses, certain bacteria, and the yeast Candida albicans.
S2764	DTNB	DTNB (Ellman’s Reag, Ellmans Reagenz, 5,5′-Dithiobis(2-nitrobenzoic acid), 5,5′-Dithiobis-2-nitrobenzoesäure) is a non-fluorescent probe used to quantify the number or concentration of thiol groups in a sample. DTNB is also an allosteric inhibitor of dengue virus protease (NS2B-NS3pro) and Streptomyces proteases.	Acta Biochim Biophys Sin (Shanghai), 2024, 56(9):1311-1322
S5020	Tilorone dihydrochloride	Tilorone dihydrochloride is a broad-spectrum, orally active antiviral agent that activates interferon production. It has antitumor, anti-inflammatory properties.
S3553	Riamilovir	Riamilovir (Triazavirin) is a broad-spectrum antiviral drug candidate, which can be used for potential application against the Coronavirus 2019-nCoV.
S5016	Isoprinosine	Isoprinosine (Inosine pranobex, Immunovir, Groprinosin, Delimmun) is an immunopharmacologic agent with antiviral activities.
S3356	Phosphonoacetic acid	Phosphonoacetic acid (PAA) is an active endogenous metabolite that possesses a restricted potential to block DNA biosynthesis. Phosphonoacetic acid exhibits anti-viral activities.
S9078	Epigoitrin	Epigoitrin (Goitrin, BA-51-090278), the main bioactive constituent of Radix isatidis, exerts antiviral, anticancer, and antithyroid activities.
E0942	BVDV IN-1	BVDV IN-1 is a non-nucleoside inhibitor of bovine viral diarrhea virus (BVDV), with an EC50 of 1.8 μM.
E0066	Theaflavin 3,3'-digallate	Theaflavin 3,3'-digallate (TF-3, ZP10, TFDG) is a black tea polyphenol and acts as a potent Zika virus (ZIKV) protease inhibitor with an IC50 of 2.3 μM.
S0163	Qstatin	QStatin is a potent and selective inhibitor of SmcR (V. harveyi LuxR homologue) with an EC50 of 208.9 nM, binding tightly to SmcR and changes the flexibility of the protein, thereby altering its transcription regulatory activity, which can be a sustainable antivibriosis agent useful in aquacultures.
S6067	2,4-dichlorobenzyl alcohol	2,4-Dichlorobenzyl alcohol is a mild antiseptic, able to kill bacteria and viruses associated with mouth and throat infections.
S9099	Orientin	Orientin (Lutexin, Luteolin-8-glucoside), isolated from medicinal plants, has various activities including anti-oxidant, anti-aging, anti-viral, anti-bacterial, anti-inflammation, vasodilatation and cardioprotective, antiadipogenesis, antinociceptive, radiation protective, neuroprotective, and antidepressant-like effects.
S9328	5,6,7-Trimethoxyflavone	5,6,7-Trimethoxyflavone (Baicalein Trimethyl Ether), methylations of the hydroxyl groups of oroxylin A or baicalein, has various pharmacological activities including antiviral, anticancer and antibacterial.
S9344	DL-Methionine	DL-Methionine is an amino acid that has a role in the defence of oxidative stress.
S9120	Scutellarein	Scutellarein (6-Hydroxyapigenin), extracted from the perennial herb Scutellaria lateriflora, has antioxidant, antitumor, anti-adipogenic, antiviral and anti-inflammatory activities	SLAS Discov, 2024, S2472-5552(24)00007-8
S9926	ML-SA1	ML-SA1 (Mucolipin synthetic agonist 1) is an activator of TRPML channels. ML-SA1 also inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC50 values of ML-SA1 against DENV2 RNA and ZIKV RNA are 8.93 μM and 52.99 μM, respectively. ML-SA1 induces autophagy. ML-SA1 can be used for the research of broad-spectrum antiviral.	Sci Rep, 2024, 14(1):24836
S4518	Chloroxylenol	Chloroxylenol is a broad-spectrum antimicrobial chemical compound used to control bacteria, algae, fungi and virus.
S9136	Neochlorogenic acid	Neochlorogenic acid (Neochlorogenate, 5-O-Caffeoylquinic acid) is a natural polyphenolic compound found in some types of dried fruits and a variety of other plant sources such as peaches. It shows antioxidant, antibacterial, antiviral, and antipyretic activities and exerts neuroprotective effects through the inhibition of pro-inflammatory pathways in activated microglia.	Biomacromolecules, 2024, 25(2):729-740
E0835	CID-1517823	CID-1517823 (ML328) is a potent and selective inhibitor of bacterial AddAB and RecBCD helicase-nucleases, with IC50s of 1.0 and 4.8 μM.
S6865	Alisporivir	Alisporivir (Debio-025) is a cyclophilin inhibitor molecule with potent anti-hepatitis C virus (HCV) activity.
S4408	Procodazole	Procodazole (Propazol, 2-Benzimidazolepropionic acid, 3-(1H-benzimidazole-2) propanoic acid) is used as a potentiator which is non-specific active immunoprotective against viral and bacterial infections.
S1102	U0126-EtOH	U0126-EtOH is a highly selective inhibitor of MEK1/2 with IC50 of 0.07 μM/0.06 μM in cell-free assays, 100-fold higher affinity for ΔN3-S218E/S222D MEK than PD98059. U0126 inhibits autophagy and mitophagy with antiviral activity.	MedComm (2020), 2024, 5(5):e525 Int J Biol Sci, 2024, 20(6):2202-2218 Cell Death Dis, 2024, 15(1):31
S1623	Acetylcysteine (N-acetylcysteine)	Acetylcysteine (N-acetyl-l-cysteine, NAC,N-acetylcysteine) is a ROS(reactive oxygen species) inhibitor that antagonizes the activity of proteasome inhibitors. It is also a tumor necrosis factor production inhibitor. Acetylcysteine(N-acetyl-l-cysteine) suppresses TNF-induced NF-κB activation through inhibition of IκB kinases. Acetylcysteine(N-acetyl-l-cysteine) induces apoptosis via the mitochondria-dependent pathway. Acetylcysteine(N-acetyl-l-cysteine) inhibits ferroptosis and virus replication.Solutions are unstable and should be fresh-prepared.	Mol Cancer, 2024, 23(1):240 Nat Commun, 2024, 15(1):4124 Nat Commun, 2024, 15(1):4124
S8932	Remdesivir (GS-5734)	Remdesivir (GS-5734), a monophosphoramidate prodrug of an adenosine analog, is an investigational broad-spectrum antiviral agent with in vitro activity against multiple RNA viruses, including Ebola and CoV.	Antiviral Res, 2024, 225:105840 Int J Mol Sci, 2024, 24;25(3):1427. Int J Mol Sci, 2024, 25(3)1427
S7775	Emricasan (IDN-6556)	Emricasan (IDN-6556, PF 03491390, PF-03491390) is a potent irreversible pan-caspase inhibitor. Emricasan is an inhibitor of Zika virus infection.	Immunity, 2024, S1074-7613(24)00221-8 Acta Neuropathol, 2024, 147(1):56 Cell Death Differ, 2024, 31(7):938-953
S1537	Vadimezan (DMXAA)	Vadimezan (DMXAA) is a vascular disrupting agents (VDA) and competitive inhibitor of DT-diaphorase with Ki of 20 μM and IC50 of 62.5 μM in cell-free assays, respectively. DMXAA (Vadimezan) is also a STING agonist with potential antineoplastic activity. DMXAA (Vadimezan) potently induces IFN-β but relatively low TNF-α expression in vitro. DMXAA (Vadimezan) has antiviral activity. Phase 3.	Mol Cancer, 2024, 23(1):186 Nat Commun, 2024, 15(1):1750 Cell Rep Med, 2024, 5(7):101648
S2239	Tubacin	Tubacin is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor with an IC50 of 4 nM in a cell-free assay, approximately 350-fold selectivity over HDAC1. Tubacin reduces the replication of the Japanese Encephalitis Virus via the decrease of viral RNA synthesis.	Dev Cell, 2024, S1534-5807(24)00326-5 Br J Cancer, 2023, 10.1038/s41416-023-02195-0 Int J Mol Sci, 2023, 24(5)4720
S2713	Geldanamycin	Geldanamycin is a natural existing HSP90 inhibitor with K_d of 1.2 μM, specifically disrupts glucocorticoid receptor (GR)/HSP association. Geldanamycin attenuates virus infection-induced ALI (acute lung injury)/ARDS (acute respiratory distress syndrome) by reducing the host's inflammatory responses.	Nat Commun, 2024, 15(1):9448 Cell Rep, 2024, 43(10):114827 Int J Mol Sci, 2023, 24(18)13830
S1401	Tenofovir	Tenofovir (GS-1278) blocks reverse transcriptase and hepatitis B virus infections.	J Biomed Sci, 2024, 31(1):34 Hepatol Commun, 2024, 8(1)e0351 Nat Commun, 2023, 14(1):199
S6814	GS-441524	GS-441524, a molecular precursor to a pharmacologically active nucleoside triphosphate molecule, is a potent inhibitor of feline infectious peritonitis virus (FIPV) with EC50 of 0.78 μM.	Infect Drug Resist, 2024, 17:531-541 Commun Biol, 2023, 6(1):511 EBioMedicine, 2022, 81:104095
S4879	Tenofovir hydrate	Tenofovir (GS-1278) hydrate blocks reverse transcriptase and hepatitis B virus infections.	Cancer Discov, 2022, candisc.1117.2021 Cells, 2020, 9(4)E1003
S8750	NGI-1	NGI-1 is an aminobenzamide-sulfonamide compound that targets both oligosaccharyltransferase (OST) isoforms and therefore may exhibit antiviral activity against flaviviruses.	Int J Mol Sci, 2024, 25(5)2768 Cancer Discov, 2023, 13(8):1862-1883 J Cell Biochem, 2022, 10.1002/jcb.30204
E0153	Lithium Chloride	Lithium Chloride (LiCl) inhibits the replication of type 1 and type 2 Herpes simplex virus at concentrations which permitted host cell replication. Lithium chloride also prevents glucocorticoid-induced osteonecrosis of femoral heads and strengthens mesenchymal stem cell activity in rats.	Mol Med Rep, 2025, 31(1)30 Mil Med Res, 2024, 11(1):27 Cell Death Dis, 2024, 15(5):332
S9303	Saikosaponin B2	Saikosaponin B2 is a naturally occurring terpenoid that efficiently inhibits hepatitis C virus entry.	Phytomedicine, 2019, 67:153163
S9063	Harringtonine	Harringtonine is a natural cephalotaxine alkaloid that inhibits protein biosynthesis. It also exhibits antiviral and anticancer activities.	BioRxiv, 2022, 10.1101/2021.04.12.439420 BioRxiv, 2021, PPR: PPR311141 Research Square, 2021, 10.21203/rs.3.rs-541829/v1
S9669	U18666A	U18666A (U18) is an inhibitor of intra-cellular cholesterol transport that inhibits dengue virus entry and replication.	Redox Biol, 2023, 63:102732
E0150	Carrageenan	Carrageenan (kappa-Carrageenan) is a natural carbohydrate (polysaccharide) obtained from edible red seaweeds. Carrageenan shows anticoagulant activity, antithrombotic activity, antiviral activity, anti-tumour activity and immunomodulatory activity.
S5554	Lanatoside C	Lanatoside C is a cardiac glycoside with antiviral and anti-tumor activity. Lanatoside C induces G2/M cell cycle arrest and induces autophagy and apoptosis via attenuating MAPK, Wnt, JAK-STAT, and PI3K/AKT/mTOR signaling pathways.
S3380	Tecovirimat	Tecovirimat is an antiviral that inhibits the egress of orthopoxviruses by targeting viral p37 protein orthologs. Tecovirimat is developed for the treatment of smallpox infection.	Microbiol Spectr, 2024, e0358623.
E0365	Fucoidan	Fucoidan is an anionic sulfated polysaccharide extracted from marine brown algae with a large range of biological activities, including anti-inflammatory, anti-cancer, anti-viral, anti-oxidation, anticoagulant, antithrombotic, anti-angiogenic and anti-Helicobacter pylori, etc.	Int J Biol Macromol, 2024, 276(Pt 1):133792
E0336	CBS1117	CBS1117 is a virus entry inhibitor with an IC50 of 70 nM for influenza A virus, A/Puerto Rico/8/34 (H1N1), also interferes with the hemagglutinin (HA)-mediated fusion process.
E0010	Hypocrellin A	Hypocrellin A (HA) is a perylenequinone isolated from Shiraia bambusicola that shows antiviral, antimicrobial and anticancer activity through mediating multiple signaling pathways. Hypocrellin A also is a selective and potent inhibitor of PKC.
S6867	Glyceryl monocaprate (Monocaprin)	Monocaprin (Glyceryl caprate) is a 1-monoglyceride of capric acid that has antimicrobial activity against enveloped viruses, certain bacteria, and the yeast Candida albicans.
S2764	DTNB	DTNB (Ellman’s Reag, Ellmans Reagenz, 5,5′-Dithiobis(2-nitrobenzoic acid), 5,5′-Dithiobis-2-nitrobenzoesäure) is a non-fluorescent probe used to quantify the number or concentration of thiol groups in a sample. DTNB is also an allosteric inhibitor of dengue virus protease (NS2B-NS3pro) and Streptomyces proteases.	Acta Biochim Biophys Sin (Shanghai), 2024, 56(9):1311-1322
S3356	Phosphonoacetic acid	Phosphonoacetic acid (PAA) is an active endogenous metabolite that possesses a restricted potential to block DNA biosynthesis. Phosphonoacetic acid exhibits anti-viral activities.
E0942	BVDV IN-1	BVDV IN-1 is a non-nucleoside inhibitor of bovine viral diarrhea virus (BVDV), with an EC50 of 1.8 μM.
E0066	Theaflavin 3,3'-digallate	Theaflavin 3,3'-digallate (TF-3, ZP10, TFDG) is a black tea polyphenol and acts as a potent Zika virus (ZIKV) protease inhibitor with an IC50 of 2.3 μM.
S0163	Qstatin	QStatin is a potent and selective inhibitor of SmcR (V. harveyi LuxR homologue) with an EC50 of 208.9 nM, binding tightly to SmcR and changes the flexibility of the protein, thereby altering its transcription regulatory activity, which can be a sustainable antivibriosis agent useful in aquacultures.
S9926	ML-SA1	ML-SA1 (Mucolipin synthetic agonist 1) is an activator of TRPML channels. ML-SA1 also inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC50 values of ML-SA1 against DENV2 RNA and ZIKV RNA are 8.93 μM and 52.99 μM, respectively. ML-SA1 induces autophagy. ML-SA1 can be used for the research of broad-spectrum antiviral.	Sci Rep, 2024, 14(1):24836
E0835	CID-1517823	CID-1517823 (ML328) is a potent and selective inhibitor of bacterial AddAB and RecBCD helicase-nucleases, with IC50s of 1.0 and 4.8 μM.
S6865	Alisporivir	Alisporivir (Debio-025) is a cyclophilin inhibitor molecule with potent anti-hepatitis C virus (HCV) activity.
S3251	Goitrin	Goitrin (DL-Goitrin, (R, S)-Goitrin, R,S-goitrin) is one of the main constituent of Radix isatidis (Banlangen) which is widely used as a traditional Chinese medicine for treating fever and removing toxic heat. Goitrin exhibits antiviral and antiendotoxin activity.

Antiviral阻害剤の選択性比較