Serotonin Transporter

Serotonin Transporter製品

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  • Serotonin Transporter阻害剤 (26)
  • Serotonin Transporterモジュレータ(1)
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S1627 Nitazoxanide Nitazoxanide is a synthetic nitrothiazolyl-salicylamide derivative and an antiprotozoal agent(IC50 for canine influenza virus ranges from 0.17 to 0.21 μM). Nitazoxanide modulates autophagy and inhibits mTORC1 signaling.
Nat Commun, 2024, 15(1):8708
Mol Ther, 2024, S1525-0016(24)00340-X
Biomed Pharmacother, 2024, 171:116195
S1336 Fluvoxamine (DU-23000) maleate Fluvoxamine maleate (DU-23000, MK-264) is a selective serotonin (5-HT) reuptake inhibitor (SSRI), used in the treatment of obsessive-compulsive disorder.
Cell Rep, 2024, 43(10):114818
Brain Res, 2024, 1838:149011
Adv Biol (Weinh), 2024, e2300511.
S4749 Citalopram HBr Citalopram HBr (Nitalapram HBr, Prepram HBr, Bonitrile HBr, Lu 10-171 HBr), an antidepressant, is an orally administered selective serotonin reuptake inhibitor (SSRI) with IC50 of 1.8 nM.
Cell Rep, 2024, 43(10):114818
Chem Biol Interact, 2024, 403:111246
Aging (Albany NY), 2021, 13(11):14729-14744
S3005 Paroxetine HCl Paroxetine HCl (BRL-29060A, FG-7051) is an antidepressant drug of the SSRI type.
Cell Rep, 2024, 43(10):114818
Nat Commun, 2022, 13(1):3034
Am J Cancer Res, 2022, 12(4):1465-1483
S2084 Duloxetine HCl Duloxetine HCl (LY-248686) is a serotonin-norepinephrine reuptake inhibitor with Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD).
Cancers (Basel), 2022, 14(19)4883
Drug Metab Dispos, 2015, 44(3):378-88
J Pharmacol Exp Ther, 2014, 349(3):402-7
S4053 Sertraline HCl Sertraline HCl (CP-51974-1) is a 5-HT antagonist with Ki of 13 nM.
Cell Rep, 2024, 43(10):114818
Antimicrob Agents Chemother, 2021, AAC.01146-20
Sci Rep, 2021, 11(1):1250
S3183 Amitriptyline HCl Amitriptyline HCl is an inhibitor of both serotonin transporter (SERT) and norepinephrine transporter (NET) with Ki of 3.45 nM and 13.3 nM, respectively. Amitriptyline HCl also inhibits histamine receptor H1, histamine receptor H4, 5-HT2 and sigma 1 receptor with Ki of 0.5 nM, 7.31 nM, 235 nM and 287 nM, respectively. Amitriptyline is a tricyclic antidepressant (TCA).
Environ Toxicol Chem, 2021, 10.1002/etc.5018
PLoS Pathog, 2020, 16;16(3):e1008341
Sci Rep, 2018, 8(1):15753
S1441 Venlafaxine HCl Venlafaxine HCl(Wy 453 HCl) is an arylalkanolamine serotonin-norepinephrine reuptake inhibitor (SNRI), used to treat major depressive disorder (MDD), generalised anxiety disorder (GAD), panic disorder and social phobia.
Am J Cancer Res, 2024, 14(3):1087-1100
Nat Commun, 2020, 14;11(1):1825
Drug Metab Dispos, 2020, 48(10):1044-1052
S2541 Clomipramine HCl Clomipramine HCl is a tricyclic antidepressant acting as a potent inhibitor of 5-HT reuptake with an IC50 value of 1.5 nM. Clomipramine hydrochloride is used in research on depression, anxiety, and obsessive-compulsive disorder (OCD).
Biomed Pharmacother, 2022, 153:113328
bioRxiv, 2020, 2020/9/20.4.7.30734
S4259 Vilazodone HCl Vilazodone HCl(EMD68843,SB659746A) is a selective serotonin reuptake inhibitor (SSRI) and a partial agonist of 5-HT1A receptors, used for the treatment of major depressive disorder.
J Pain, 2019, 20(1):16.e1-16.e16
Acta Pol Pharm, 2017, 74(3):765-775
S5239 Paroxetine mesylate Paroxetine Mesylate(BRL-29060A mesylate,FG-7051 mesylate) is the mesylate salt form of paroxetine, a phenylpiperidine derivative and a selective serotonin reuptake inhibitor (SSRI) with antidepressant and anxiolytic properties.
Am J Cancer Res, 2022, 12(4):1465-1483
Anal Methods, 2021, 10.1039/d0ay02027c
S2282 Cinchonidine Cinchonidine is an alkaloid used in asymmetric synthesis in organic chemistry.
CNS Neurosci Ther, 2023, 10.1111/cns.14403
J Med Virol, 2019, 91(8):1440-1447
S4377 Imipramine HCl Imipramine (Melipramine,G 22355) is a tricyclic antidepressant (TCA) of the dibenzazepine group, mainly used in the treatment of major depression and enuresis (inability to control urination).
Cancer Drug Resist, 2022, 5(3):612-624
Antioxidants (Basel), 2021, 10(6)956
S6301 MPP+ iodide MPP+ iodide (N-Methyl-4-Phenylpyridinium Iodide), the metabolite of a neurotoxin MPTP, causes symptom of Parkinson's disease (PD) in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ induces autophagic cell death in SH-SY5Y cells. MPP+ induces dopamine transporter (DAT) externalization in dopaminergic (DA) neurons, but internalization of serotonin transporter (SERT) in serotonergic (5-HT) neurons.
Front Immunol, 2023, 14:1193081
Front Immunol, 2023, 14:1193081
S4113 Desvenlafaxine Desvenlafaxine (WY 45233 Succinate) is a serotonin (5-HT) and norepinephrine (NE) reuptake inhibitor with Ki of 40.2 nM and 558.4 nM, respectively.
Am J Cancer Res, 2024, 14(3):1087-1100
Drug Metab Dispos, 2020, 48(10):1044-1052
S4064 Escitalopram Oxalate Escitalopram Oxalate is a selective serotonin (5-HT) reuptake inhibitor (SSRI) with Ki of 0.89 nM.
Cell Rep, 2024, 43(10):114818
J Matern Fetal Neonatal Med, 2023, 36(1):2183468
S5947 Amitriptyline Amitriptyline (MK-230, N-750, Ro41575) is a tricyclic antidepressant (TCA) with analgesic properties, widely used to treat depression and neuropathic pain. Amitriptyline is an inhibitor of both serotonin transporter (SERT) and norepinephrine transporter (NET) with Ki of 3.45 nM and 13.3 nM, respectively. Amitriptyline also inhibits histamine receptor H1, histamine receptor H4, 5-HT2 and sigma 1 receptor with Ki of 0.5 nM, 7.31 nM, 235 nM and 287 nM, respectively. This product is a waxy solid.
Cancers (Basel), 2019, 11(12)
S4112 Desvenlafaxine Succinate hydrate Desvenlafaxine Succinate hydrate (WY 45233) is a new serotonin (5-HT) transporter and norepinephrine (NE) transporter reuptake inhibitor with Ki of 40.2 nM and 558.4 nM respectively.
Drug Metab Dispos, 2020, 48(10):1044-1052
S5858 Vilazodone Vilazodone (EMD-68843, SB-659746A) is a novel antidepressant having a selective serotonin (5-HT) reuptake inhibitory and 5-HT1A receptor partial agonist activity. The affinity of vilazodone is much higher in the 5-HT reuptake site (Ki=0.1 nM) than in norepinephrine (Ki=56 nM) and dopamine (Ki=37 nM) sites.
J Pain, 2019, 20(1):16.e1-16.e16
S1869 Dapoxetine HCl Dapoxetine HCl (LY-210448) is a short-acting novel selective serotonin reuptake inhibitor, used for the treatment of premature ejaculation.
S3140 Milnacipran HCl Milnacipran inhibits both norepinephrine transporter (NET) and norepinephrine transporter (SERT) with IC50 of 77 nM and 420 nM, respectively.
Am J Cancer Res, 2024, 14(3):1087-1100
S5693 Levomilnacipran Hydrochloride Levomilnacipran Hydrochloride is a selective serotonin and norepinephrine reuptake inhibitor with antidepressant activity.
E4887New Dapoxetine Dapoxetine ((S)-(+)-Dapoxetine; LY-210448) is a selective serotonin reuptake inhibitor (SSRI) with oral activity. Dapoxetine is a short-acting SSRI developed specifically for the treatment of premature ejaculation (PE).
S5655 Venlafaxine Venlafaxine (Wy 45030) is an arylalkanolamine serotonin-norepinephrine reuptake inhibitor (SNRI), used to treat major depressive disorder (MDD), generalised anxiety disorder (GAD), panic disorder and social phobia.
S5485 Desipramine Hydrochloride Desipramine hydrochloride (Desmethylimipramine, Norimipramine, EX-4355, G-35020, JB-8181, NSC-114901) is a dibenzazepine-derivative tricyclic antidepressant that acts as a selective norepinephrine reuptake inhibitor. It also shows weak serotonin reuptake inhibitory, α1-blocking, antihistamine, and anticholinergic effects.
E4898New Escitalopram Escitalopram ((S)-Citalopram), (S)-+ Citalopram)) is a selective serotonin reuptake inhibitor (SSRI) with a Ki value of 0.89 nM. Escitalopram has approximately 30-fold higher binding affinity than its R(-)-enantiomer and exhibits selectivity over both norepinephrine transporter (NET) and dopamine transporter (DAT).
S5071 Duloxetine Duloxetine (LY-248686) is a potent inhibitor of serotonin (5-hydroxytryptamine, 5-HT) and noradrenaline (NE) uptake in vitro and in vivo and is 3- to 5-times more effective at inhibiting 5-HT uptake.
S1627 Nitazoxanide Nitazoxanide is a synthetic nitrothiazolyl-salicylamide derivative and an antiprotozoal agent(IC50 for canine influenza virus ranges from 0.17 to 0.21 μM). Nitazoxanide modulates autophagy and inhibits mTORC1 signaling.
Nat Commun, 2024, 15(1):8708
Mol Ther, 2024, S1525-0016(24)00340-X
Biomed Pharmacother, 2024, 171:116195
S1336 Fluvoxamine (DU-23000) maleate Fluvoxamine maleate (DU-23000, MK-264) is a selective serotonin (5-HT) reuptake inhibitor (SSRI), used in the treatment of obsessive-compulsive disorder.
Cell Rep, 2024, 43(10):114818
Brain Res, 2024, 1838:149011
Adv Biol (Weinh), 2024, e2300511.
S4749 Citalopram HBr Citalopram HBr (Nitalapram HBr, Prepram HBr, Bonitrile HBr, Lu 10-171 HBr), an antidepressant, is an orally administered selective serotonin reuptake inhibitor (SSRI) with IC50 of 1.8 nM.
Cell Rep, 2024, 43(10):114818
Chem Biol Interact, 2024, 403:111246
Aging (Albany NY), 2021, 13(11):14729-14744
S3005 Paroxetine HCl Paroxetine HCl (BRL-29060A, FG-7051) is an antidepressant drug of the SSRI type.
Cell Rep, 2024, 43(10):114818
Nat Commun, 2022, 13(1):3034
Am J Cancer Res, 2022, 12(4):1465-1483
S2084 Duloxetine HCl Duloxetine HCl (LY-248686) is a serotonin-norepinephrine reuptake inhibitor with Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD).
Cancers (Basel), 2022, 14(19)4883
Drug Metab Dispos, 2015, 44(3):378-88
J Pharmacol Exp Ther, 2014, 349(3):402-7
S4053 Sertraline HCl Sertraline HCl (CP-51974-1) is a 5-HT antagonist with Ki of 13 nM.
Cell Rep, 2024, 43(10):114818
Antimicrob Agents Chemother, 2021, AAC.01146-20
Sci Rep, 2021, 11(1):1250
S3183 Amitriptyline HCl Amitriptyline HCl is an inhibitor of both serotonin transporter (SERT) and norepinephrine transporter (NET) with Ki of 3.45 nM and 13.3 nM, respectively. Amitriptyline HCl also inhibits histamine receptor H1, histamine receptor H4, 5-HT2 and sigma 1 receptor with Ki of 0.5 nM, 7.31 nM, 235 nM and 287 nM, respectively. Amitriptyline is a tricyclic antidepressant (TCA).
Environ Toxicol Chem, 2021, 10.1002/etc.5018
PLoS Pathog, 2020, 16;16(3):e1008341
Sci Rep, 2018, 8(1):15753
S1441 Venlafaxine HCl Venlafaxine HCl(Wy 453 HCl) is an arylalkanolamine serotonin-norepinephrine reuptake inhibitor (SNRI), used to treat major depressive disorder (MDD), generalised anxiety disorder (GAD), panic disorder and social phobia.
Am J Cancer Res, 2024, 14(3):1087-1100
Nat Commun, 2020, 14;11(1):1825
Drug Metab Dispos, 2020, 48(10):1044-1052
S2541 Clomipramine HCl Clomipramine HCl is a tricyclic antidepressant acting as a potent inhibitor of 5-HT reuptake with an IC50 value of 1.5 nM. Clomipramine hydrochloride is used in research on depression, anxiety, and obsessive-compulsive disorder (OCD).
Biomed Pharmacother, 2022, 153:113328
bioRxiv, 2020, 2020/9/20.4.7.30734
S4259 Vilazodone HCl Vilazodone HCl(EMD68843,SB659746A) is a selective serotonin reuptake inhibitor (SSRI) and a partial agonist of 5-HT1A receptors, used for the treatment of major depressive disorder.
J Pain, 2019, 20(1):16.e1-16.e16
Acta Pol Pharm, 2017, 74(3):765-775
S5239 Paroxetine mesylate Paroxetine Mesylate(BRL-29060A mesylate,FG-7051 mesylate) is the mesylate salt form of paroxetine, a phenylpiperidine derivative and a selective serotonin reuptake inhibitor (SSRI) with antidepressant and anxiolytic properties.
Am J Cancer Res, 2022, 12(4):1465-1483
Anal Methods, 2021, 10.1039/d0ay02027c
S2282 Cinchonidine Cinchonidine is an alkaloid used in asymmetric synthesis in organic chemistry.
CNS Neurosci Ther, 2023, 10.1111/cns.14403
J Med Virol, 2019, 91(8):1440-1447
S4377 Imipramine HCl Imipramine (Melipramine,G 22355) is a tricyclic antidepressant (TCA) of the dibenzazepine group, mainly used in the treatment of major depression and enuresis (inability to control urination).
Cancer Drug Resist, 2022, 5(3):612-624
Antioxidants (Basel), 2021, 10(6)956
S4113 Desvenlafaxine Desvenlafaxine (WY 45233 Succinate) is a serotonin (5-HT) and norepinephrine (NE) reuptake inhibitor with Ki of 40.2 nM and 558.4 nM, respectively.
Am J Cancer Res, 2024, 14(3):1087-1100
Drug Metab Dispos, 2020, 48(10):1044-1052
S4064 Escitalopram Oxalate Escitalopram Oxalate is a selective serotonin (5-HT) reuptake inhibitor (SSRI) with Ki of 0.89 nM.
Cell Rep, 2024, 43(10):114818
J Matern Fetal Neonatal Med, 2023, 36(1):2183468
S5947 Amitriptyline Amitriptyline (MK-230, N-750, Ro41575) is a tricyclic antidepressant (TCA) with analgesic properties, widely used to treat depression and neuropathic pain. Amitriptyline is an inhibitor of both serotonin transporter (SERT) and norepinephrine transporter (NET) with Ki of 3.45 nM and 13.3 nM, respectively. Amitriptyline also inhibits histamine receptor H1, histamine receptor H4, 5-HT2 and sigma 1 receptor with Ki of 0.5 nM, 7.31 nM, 235 nM and 287 nM, respectively. This product is a waxy solid.
Cancers (Basel), 2019, 11(12)
S4112 Desvenlafaxine Succinate hydrate Desvenlafaxine Succinate hydrate (WY 45233) is a new serotonin (5-HT) transporter and norepinephrine (NE) transporter reuptake inhibitor with Ki of 40.2 nM and 558.4 nM respectively.
Drug Metab Dispos, 2020, 48(10):1044-1052
S5858 Vilazodone Vilazodone (EMD-68843, SB-659746A) is a novel antidepressant having a selective serotonin (5-HT) reuptake inhibitory and 5-HT1A receptor partial agonist activity. The affinity of vilazodone is much higher in the 5-HT reuptake site (Ki=0.1 nM) than in norepinephrine (Ki=56 nM) and dopamine (Ki=37 nM) sites.
J Pain, 2019, 20(1):16.e1-16.e16
S1869 Dapoxetine HCl Dapoxetine HCl (LY-210448) is a short-acting novel selective serotonin reuptake inhibitor, used for the treatment of premature ejaculation.
S3140 Milnacipran HCl Milnacipran inhibits both norepinephrine transporter (NET) and norepinephrine transporter (SERT) with IC50 of 77 nM and 420 nM, respectively.
Am J Cancer Res, 2024, 14(3):1087-1100
S5693 Levomilnacipran Hydrochloride Levomilnacipran Hydrochloride is a selective serotonin and norepinephrine reuptake inhibitor with antidepressant activity.
E4887New Dapoxetine Dapoxetine ((S)-(+)-Dapoxetine; LY-210448) is a selective serotonin reuptake inhibitor (SSRI) with oral activity. Dapoxetine is a short-acting SSRI developed specifically for the treatment of premature ejaculation (PE).
S5655 Venlafaxine Venlafaxine (Wy 45030) is an arylalkanolamine serotonin-norepinephrine reuptake inhibitor (SNRI), used to treat major depressive disorder (MDD), generalised anxiety disorder (GAD), panic disorder and social phobia.
S5485 Desipramine Hydrochloride Desipramine hydrochloride (Desmethylimipramine, Norimipramine, EX-4355, G-35020, JB-8181, NSC-114901) is a dibenzazepine-derivative tricyclic antidepressant that acts as a selective norepinephrine reuptake inhibitor. It also shows weak serotonin reuptake inhibitory, α1-blocking, antihistamine, and anticholinergic effects.
E4898New Escitalopram Escitalopram ((S)-Citalopram), (S)-+ Citalopram)) is a selective serotonin reuptake inhibitor (SSRI) with a Ki value of 0.89 nM. Escitalopram has approximately 30-fold higher binding affinity than its R(-)-enantiomer and exhibits selectivity over both norepinephrine transporter (NET) and dopamine transporter (DAT).
S5071 Duloxetine Duloxetine (LY-248686) is a potent inhibitor of serotonin (5-hydroxytryptamine, 5-HT) and noradrenaline (NE) uptake in vitro and in vivo and is 3- to 5-times more effective at inhibiting 5-HT uptake.
S6301 MPP+ iodide MPP+ iodide (N-Methyl-4-Phenylpyridinium Iodide), the metabolite of a neurotoxin MPTP, causes symptom of Parkinson's disease (PD) in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ induces autophagic cell death in SH-SY5Y cells. MPP+ induces dopamine transporter (DAT) externalization in dopaminergic (DA) neurons, but internalization of serotonin transporter (SERT) in serotonergic (5-HT) neurons.
Front Immunol, 2023, 14:1193081
Front Immunol, 2023, 14:1193081
E4887New Dapoxetine Dapoxetine ((S)-(+)-Dapoxetine; LY-210448) is a selective serotonin reuptake inhibitor (SSRI) with oral activity. Dapoxetine is a short-acting SSRI developed specifically for the treatment of premature ejaculation (PE).
E4898New Escitalopram Escitalopram ((S)-Citalopram), (S)-+ Citalopram)) is a selective serotonin reuptake inhibitor (SSRI) with a Ki value of 0.89 nM. Escitalopram has approximately 30-fold higher binding affinity than its R(-)-enantiomer and exhibits selectivity over both norepinephrine transporter (NET) and dopamine transporter (DAT).

Serotonin Transporter阻害剤の選択性比較

Tags: Serotonin Transporter inhibitor|Serotonin Transporter agonist|Serotonin Transporter activator|Serotonin Transporter inducer|Serotonin Transporter antagonist|Serotonin Transporter signaling pathway|Serotonin Transporter assay kit