S1627 |
Nitazoxanide
|
Nitazoxanide is a synthetic nitrothiazolyl-salicylamide derivative and an antiprotozoal agent(IC50 for canine influenza virus ranges from 0.17 to 0.21 μM). Nitazoxanide modulates autophagy and inhibits mTORC1 signaling. |
-
Nat Commun, 2024, 15(1):8708
-
Mol Ther, 2024, S1525-0016(24)00340-X
-
Biomed Pharmacother, 2024, 171:116195
|
|
S1336 |
Fluvoxamine (DU-23000) maleate
|
Fluvoxamine maleate (DU-23000, MK-264) is a selective serotonin (5-HT) reuptake inhibitor (SSRI), used in the treatment of obsessive-compulsive disorder. |
-
Cell Rep, 2024, 43(10):114818
-
Brain Res, 2024, 1838:149011
-
Adv Biol (Weinh), 2024, e2300511.
|
|
S4749 |
Citalopram HBr
|
Citalopram HBr (Nitalapram HBr, Prepram HBr, Bonitrile HBr, Lu 10-171 HBr), an antidepressant, is an orally administered selective serotonin reuptake inhibitor (SSRI) with IC50 of 1.8 nM. |
-
Cell Rep, 2024, 43(10):114818
-
Chem Biol Interact, 2024, 403:111246
-
Aging (Albany NY), 2021, 13(11):14729-14744
|
|
S3005 |
Paroxetine HCl
|
Paroxetine HCl (BRL-29060A, FG-7051) is an antidepressant drug of the SSRI type. |
-
Cell Rep, 2024, 43(10):114818
-
Nat Commun, 2022, 13(1):3034
-
Am J Cancer Res, 2022, 12(4):1465-1483
|
|
S2084 |
Duloxetine HCl
|
Duloxetine HCl (LY-248686) is a serotonin-norepinephrine reuptake inhibitor with Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD). |
-
Cancers (Basel), 2022, 14(19)4883
-
Drug Metab Dispos, 2015, 44(3):378-88
-
J Pharmacol Exp Ther, 2014, 349(3):402-7
|
|
S4053 |
Sertraline HCl
|
Sertraline HCl (CP-51974-1) is a 5-HT antagonist with Ki of 13 nM. |
-
Cell Rep, 2024, 43(10):114818
-
Antimicrob Agents Chemother, 2021, AAC.01146-20
-
Sci Rep, 2021, 11(1):1250
|
|
S3183 |
Amitriptyline HCl
|
Amitriptyline HCl is an inhibitor of both serotonin transporter (SERT) and norepinephrine transporter (NET) with Ki of 3.45 nM and 13.3 nM, respectively. Amitriptyline HCl also inhibits histamine receptor H1, histamine receptor H4, 5-HT2 and sigma 1 receptor with Ki of 0.5 nM, 7.31 nM, 235 nM and 287 nM, respectively. Amitriptyline is a tricyclic antidepressant (TCA). |
-
Environ Toxicol Chem, 2021, 10.1002/etc.5018
-
PLoS Pathog, 2020, 16;16(3):e1008341
-
Sci Rep, 2018, 8(1):15753
|
|
S1441 |
Venlafaxine HCl
|
Venlafaxine HCl(Wy 453 HCl) is an arylalkanolamine serotonin-norepinephrine reuptake inhibitor (SNRI), used to treat major depressive disorder (MDD), generalised anxiety disorder (GAD), panic disorder and social phobia. |
-
Am J Cancer Res, 2024, 14(3):1087-1100
-
Nat Commun, 2020, 14;11(1):1825
-
Drug Metab Dispos, 2020, 48(10):1044-1052
|
|
S2541 |
Clomipramine HCl
|
Clomipramine HCl is a tricyclic antidepressant acting as a potent inhibitor of 5-HT reuptake with an IC50 value of 1.5 nM. Clomipramine hydrochloride is used in research on depression, anxiety, and obsessive-compulsive disorder (OCD). |
-
Biomed Pharmacother, 2022, 153:113328
-
bioRxiv, 2020, 2020/9/20.4.7.30734
|
|
S4259 |
Vilazodone HCl
|
Vilazodone HCl(EMD68843,SB659746A) is a selective serotonin reuptake inhibitor (SSRI) and a partial agonist of 5-HT1A receptors, used for the treatment of major depressive disorder. |
-
J Pain, 2019, 20(1):16.e1-16.e16
-
Acta Pol Pharm, 2017, 74(3):765-775
|
|
S5239 |
Paroxetine mesylate
|
Paroxetine Mesylate(BRL-29060A mesylate,FG-7051 mesylate) is the mesylate salt form of paroxetine, a phenylpiperidine derivative and a selective serotonin reuptake inhibitor (SSRI) with antidepressant and anxiolytic properties. |
-
Am J Cancer Res, 2022, 12(4):1465-1483
-
Anal Methods, 2021, 10.1039/d0ay02027c
|
|
S2282 |
Cinchonidine
|
Cinchonidine is an alkaloid used in asymmetric synthesis in organic chemistry. |
-
CNS Neurosci Ther, 2023, 10.1111/cns.14403
-
J Med Virol, 2019, 91(8):1440-1447
|
|
S4377 |
Imipramine HCl
|
Imipramine (Melipramine,G 22355) is a tricyclic antidepressant (TCA) of the dibenzazepine group, mainly used in the treatment of major depression and enuresis (inability to control urination). |
-
Cancer Drug Resist, 2022, 5(3):612-624
-
Antioxidants (Basel), 2021, 10(6)956
|
|
S6301 |
MPP+ iodide
|
MPP+ iodide (N-Methyl-4-Phenylpyridinium Iodide), the metabolite of a neurotoxin MPTP, causes symptom of Parkinson's disease (PD) in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ induces autophagic cell death in SH-SY5Y cells. MPP+ induces dopamine transporter (DAT) externalization in dopaminergic (DA) neurons, but internalization of serotonin transporter (SERT) in serotonergic (5-HT) neurons. |
-
Front Immunol, 2023, 14:1193081
-
Front Immunol, 2023, 14:1193081
|
|
S4113 |
Desvenlafaxine
|
Desvenlafaxine (WY 45233 Succinate) is a serotonin (5-HT) and norepinephrine (NE) reuptake inhibitor with Ki of 40.2 nM and 558.4 nM, respectively. |
-
Am J Cancer Res, 2024, 14(3):1087-1100
-
Drug Metab Dispos, 2020, 48(10):1044-1052
|
|
S4064 |
Escitalopram Oxalate
|
Escitalopram Oxalate is a selective serotonin (5-HT) reuptake inhibitor (SSRI) with Ki of 0.89 nM. |
-
Cell Rep, 2024, 43(10):114818
-
J Matern Fetal Neonatal Med, 2023, 36(1):2183468
|
|
S5947 |
Amitriptyline
|
Amitriptyline (MK-230, N-750, Ro41575) is a tricyclic antidepressant (TCA) with analgesic properties, widely used to treat depression and neuropathic pain. Amitriptyline is an inhibitor of both serotonin transporter (SERT) and norepinephrine transporter (NET) with Ki of 3.45 nM and 13.3 nM, respectively. Amitriptyline also inhibits histamine receptor H1, histamine receptor H4, 5-HT2 and sigma 1 receptor with Ki of 0.5 nM, 7.31 nM, 235 nM and 287 nM, respectively. This product is a waxy solid. |
-
Cancers (Basel), 2019, 11(12)
|
|
S4112 |
Desvenlafaxine Succinate hydrate
|
Desvenlafaxine Succinate hydrate (WY 45233) is a new serotonin (5-HT) transporter and norepinephrine (NE) transporter reuptake inhibitor with Ki of 40.2 nM and 558.4 nM respectively. |
-
Drug Metab Dispos, 2020, 48(10):1044-1052
|
|
S5858 |
Vilazodone
|
Vilazodone (EMD-68843, SB-659746A) is a novel antidepressant having a selective serotonin (5-HT) reuptake inhibitory and 5-HT1A receptor partial agonist activity. The affinity of vilazodone is much higher in the 5-HT reuptake site (Ki=0.1 nM) than in norepinephrine (Ki=56 nM) and dopamine (Ki=37 nM) sites. |
-
J Pain, 2019, 20(1):16.e1-16.e16
|
|
S1869 |
Dapoxetine HCl
|
Dapoxetine HCl (LY-210448) is a short-acting novel selective serotonin reuptake inhibitor, used for the treatment of premature ejaculation. |
|
|
S3140 |
Milnacipran HCl
|
Milnacipran inhibits both norepinephrine transporter (NET) and norepinephrine transporter (SERT) with IC50 of 77 nM and 420 nM, respectively. |
-
Am J Cancer Res, 2024, 14(3):1087-1100
|
|
S5693 |
Levomilnacipran Hydrochloride
|
Levomilnacipran Hydrochloride is a selective serotonin and norepinephrine reuptake inhibitor with antidepressant activity. |
|
|
E4887New |
Dapoxetine
|
Dapoxetine ((S)-(+)-Dapoxetine; LY-210448) is a selective serotonin reuptake inhibitor (SSRI) with oral activity. Dapoxetine is a short-acting SSRI developed specifically for the treatment of premature ejaculation (PE). |
|
|
S5655 |
Venlafaxine
|
Venlafaxine (Wy 45030) is an arylalkanolamine serotonin-norepinephrine reuptake inhibitor (SNRI), used to treat major depressive disorder (MDD), generalised anxiety disorder (GAD), panic disorder and social phobia. |
|
|
S5485 |
Desipramine Hydrochloride
|
Desipramine hydrochloride (Desmethylimipramine, Norimipramine, EX-4355, G-35020, JB-8181, NSC-114901) is a dibenzazepine-derivative tricyclic antidepressant that acts as a selective norepinephrine reuptake inhibitor. It also shows weak serotonin reuptake inhibitory, α1-blocking, antihistamine, and anticholinergic effects. |
|
|
E4898New |
Escitalopram
|
Escitalopram ((S)-Citalopram), (S)-+ Citalopram)) is a selective serotonin reuptake inhibitor (SSRI) with a Ki value of 0.89 nM. Escitalopram has approximately 30-fold higher binding affinity than its R(-)-enantiomer and exhibits selectivity over both norepinephrine transporter (NET) and dopamine transporter (DAT). |
|
|
S5071 |
Duloxetine
|
Duloxetine (LY-248686) is a potent inhibitor of serotonin (5-hydroxytryptamine, 5-HT) and noradrenaline (NE) uptake in vitro and in vivo and is 3- to 5-times more effective at inhibiting 5-HT uptake. |
|
|
S1627 |
Nitazoxanide
|
Nitazoxanide is a synthetic nitrothiazolyl-salicylamide derivative and an antiprotozoal agent(IC50 for canine influenza virus ranges from 0.17 to 0.21 μM). Nitazoxanide modulates autophagy and inhibits mTORC1 signaling. |
- Nat Commun, 2024, 15(1):8708
- Mol Ther, 2024, S1525-0016(24)00340-X
- Biomed Pharmacother, 2024, 171:116195
|
|
S1336 |
Fluvoxamine (DU-23000) maleate
|
Fluvoxamine maleate (DU-23000, MK-264) is a selective serotonin (5-HT) reuptake inhibitor (SSRI), used in the treatment of obsessive-compulsive disorder. |
- Cell Rep, 2024, 43(10):114818
- Brain Res, 2024, 1838:149011
- Adv Biol (Weinh), 2024, e2300511.
|
|
S4749 |
Citalopram HBr
|
Citalopram HBr (Nitalapram HBr, Prepram HBr, Bonitrile HBr, Lu 10-171 HBr), an antidepressant, is an orally administered selective serotonin reuptake inhibitor (SSRI) with IC50 of 1.8 nM. |
- Cell Rep, 2024, 43(10):114818
- Chem Biol Interact, 2024, 403:111246
- Aging (Albany NY), 2021, 13(11):14729-14744
|
|
S3005 |
Paroxetine HCl
|
Paroxetine HCl (BRL-29060A, FG-7051) is an antidepressant drug of the SSRI type. |
- Cell Rep, 2024, 43(10):114818
- Nat Commun, 2022, 13(1):3034
- Am J Cancer Res, 2022, 12(4):1465-1483
|
|
S2084 |
Duloxetine HCl
|
Duloxetine HCl (LY-248686) is a serotonin-norepinephrine reuptake inhibitor with Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD). |
- Cancers (Basel), 2022, 14(19)4883
- Drug Metab Dispos, 2015, 44(3):378-88
- J Pharmacol Exp Ther, 2014, 349(3):402-7
|
|
S4053 |
Sertraline HCl
|
Sertraline HCl (CP-51974-1) is a 5-HT antagonist with Ki of 13 nM. |
- Cell Rep, 2024, 43(10):114818
- Antimicrob Agents Chemother, 2021, AAC.01146-20
- Sci Rep, 2021, 11(1):1250
|
|
S3183 |
Amitriptyline HCl
|
Amitriptyline HCl is an inhibitor of both serotonin transporter (SERT) and norepinephrine transporter (NET) with Ki of 3.45 nM and 13.3 nM, respectively. Amitriptyline HCl also inhibits histamine receptor H1, histamine receptor H4, 5-HT2 and sigma 1 receptor with Ki of 0.5 nM, 7.31 nM, 235 nM and 287 nM, respectively. Amitriptyline is a tricyclic antidepressant (TCA). |
- Environ Toxicol Chem, 2021, 10.1002/etc.5018
- PLoS Pathog, 2020, 16;16(3):e1008341
- Sci Rep, 2018, 8(1):15753
|
|
S1441 |
Venlafaxine HCl
|
Venlafaxine HCl(Wy 453 HCl) is an arylalkanolamine serotonin-norepinephrine reuptake inhibitor (SNRI), used to treat major depressive disorder (MDD), generalised anxiety disorder (GAD), panic disorder and social phobia. |
- Am J Cancer Res, 2024, 14(3):1087-1100
- Nat Commun, 2020, 14;11(1):1825
- Drug Metab Dispos, 2020, 48(10):1044-1052
|
|
S2541 |
Clomipramine HCl
|
Clomipramine HCl is a tricyclic antidepressant acting as a potent inhibitor of 5-HT reuptake with an IC50 value of 1.5 nM. Clomipramine hydrochloride is used in research on depression, anxiety, and obsessive-compulsive disorder (OCD). |
- Biomed Pharmacother, 2022, 153:113328
- bioRxiv, 2020, 2020/9/20.4.7.30734
|
|
S4259 |
Vilazodone HCl
|
Vilazodone HCl(EMD68843,SB659746A) is a selective serotonin reuptake inhibitor (SSRI) and a partial agonist of 5-HT1A receptors, used for the treatment of major depressive disorder. |
- J Pain, 2019, 20(1):16.e1-16.e16
- Acta Pol Pharm, 2017, 74(3):765-775
|
|
S5239 |
Paroxetine mesylate
|
Paroxetine Mesylate(BRL-29060A mesylate,FG-7051 mesylate) is the mesylate salt form of paroxetine, a phenylpiperidine derivative and a selective serotonin reuptake inhibitor (SSRI) with antidepressant and anxiolytic properties. |
- Am J Cancer Res, 2022, 12(4):1465-1483
- Anal Methods, 2021, 10.1039/d0ay02027c
|
|
S2282 |
Cinchonidine
|
Cinchonidine is an alkaloid used in asymmetric synthesis in organic chemistry. |
- CNS Neurosci Ther, 2023, 10.1111/cns.14403
- J Med Virol, 2019, 91(8):1440-1447
|
|
S4377 |
Imipramine HCl
|
Imipramine (Melipramine,G 22355) is a tricyclic antidepressant (TCA) of the dibenzazepine group, mainly used in the treatment of major depression and enuresis (inability to control urination). |
- Cancer Drug Resist, 2022, 5(3):612-624
- Antioxidants (Basel), 2021, 10(6)956
|
|
S4113 |
Desvenlafaxine
|
Desvenlafaxine (WY 45233 Succinate) is a serotonin (5-HT) and norepinephrine (NE) reuptake inhibitor with Ki of 40.2 nM and 558.4 nM, respectively. |
- Am J Cancer Res, 2024, 14(3):1087-1100
- Drug Metab Dispos, 2020, 48(10):1044-1052
|
|
S4064 |
Escitalopram Oxalate
|
Escitalopram Oxalate is a selective serotonin (5-HT) reuptake inhibitor (SSRI) with Ki of 0.89 nM. |
- Cell Rep, 2024, 43(10):114818
- J Matern Fetal Neonatal Med, 2023, 36(1):2183468
|
|
S5947 |
Amitriptyline
|
Amitriptyline (MK-230, N-750, Ro41575) is a tricyclic antidepressant (TCA) with analgesic properties, widely used to treat depression and neuropathic pain. Amitriptyline is an inhibitor of both serotonin transporter (SERT) and norepinephrine transporter (NET) with Ki of 3.45 nM and 13.3 nM, respectively. Amitriptyline also inhibits histamine receptor H1, histamine receptor H4, 5-HT2 and sigma 1 receptor with Ki of 0.5 nM, 7.31 nM, 235 nM and 287 nM, respectively. This product is a waxy solid. |
- Cancers (Basel), 2019, 11(12)
|
|
S4112 |
Desvenlafaxine Succinate hydrate
|
Desvenlafaxine Succinate hydrate (WY 45233) is a new serotonin (5-HT) transporter and norepinephrine (NE) transporter reuptake inhibitor with Ki of 40.2 nM and 558.4 nM respectively. |
- Drug Metab Dispos, 2020, 48(10):1044-1052
|
|
S5858 |
Vilazodone
|
Vilazodone (EMD-68843, SB-659746A) is a novel antidepressant having a selective serotonin (5-HT) reuptake inhibitory and 5-HT1A receptor partial agonist activity. The affinity of vilazodone is much higher in the 5-HT reuptake site (Ki=0.1 nM) than in norepinephrine (Ki=56 nM) and dopamine (Ki=37 nM) sites. |
- J Pain, 2019, 20(1):16.e1-16.e16
|
|
S1869 |
Dapoxetine HCl
|
Dapoxetine HCl (LY-210448) is a short-acting novel selective serotonin reuptake inhibitor, used for the treatment of premature ejaculation. |
|
|
S3140 |
Milnacipran HCl
|
Milnacipran inhibits both norepinephrine transporter (NET) and norepinephrine transporter (SERT) with IC50 of 77 nM and 420 nM, respectively. |
- Am J Cancer Res, 2024, 14(3):1087-1100
|
|
S5693 |
Levomilnacipran Hydrochloride
|
Levomilnacipran Hydrochloride is a selective serotonin and norepinephrine reuptake inhibitor with antidepressant activity. |
|
|
E4887New |
Dapoxetine
|
Dapoxetine ((S)-(+)-Dapoxetine; LY-210448) is a selective serotonin reuptake inhibitor (SSRI) with oral activity. Dapoxetine is a short-acting SSRI developed specifically for the treatment of premature ejaculation (PE). |
|
|
S5655 |
Venlafaxine
|
Venlafaxine (Wy 45030) is an arylalkanolamine serotonin-norepinephrine reuptake inhibitor (SNRI), used to treat major depressive disorder (MDD), generalised anxiety disorder (GAD), panic disorder and social phobia. |
|
|
S5485 |
Desipramine Hydrochloride
|
Desipramine hydrochloride (Desmethylimipramine, Norimipramine, EX-4355, G-35020, JB-8181, NSC-114901) is a dibenzazepine-derivative tricyclic antidepressant that acts as a selective norepinephrine reuptake inhibitor. It also shows weak serotonin reuptake inhibitory, α1-blocking, antihistamine, and anticholinergic effects. |
|
|
E4898New |
Escitalopram
|
Escitalopram ((S)-Citalopram), (S)-+ Citalopram)) is a selective serotonin reuptake inhibitor (SSRI) with a Ki value of 0.89 nM. Escitalopram has approximately 30-fold higher binding affinity than its R(-)-enantiomer and exhibits selectivity over both norepinephrine transporter (NET) and dopamine transporter (DAT). |
|
|
S5071 |
Duloxetine
|
Duloxetine (LY-248686) is a potent inhibitor of serotonin (5-hydroxytryptamine, 5-HT) and noradrenaline (NE) uptake in vitro and in vivo and is 3- to 5-times more effective at inhibiting 5-HT uptake. |
|
|