Vorinostat (SAHA)

別名：MK0683, Suberoylanilide hydroxamic acid

製品コード：S1047 純度：99.96%

Vorinostat (SAHA) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay. Vorinostat abrogates productive HPV-18 DNA amplification.

CAS No. 149647-78-9

サイズ	価格(税別)	在庫状況
10mM (1mL in DMSO)	JPY 28600	国内在庫あり
200mg	JPY 22000	国内在庫あり
500mg	JPY 33000	国内在庫あり
2g	JPY 73500	国内在庫あり
10g	JPY 220500	国内在庫なし(納期7~10日)

代表番号: 045-509-1970\|電子メール：[email protected] よく尋ねられる質問

文献中Selleckの製品使用例（559）

製品安全説明書

現在のバッチを見る：純度： 99.96%

99.96

Vorinostat (SAHA)関連製品

関連ターゲット	HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2	もっと見る
関連製品	Entinostat (MS-275) TSA (Trichostatin A) Mocetinostat (MGCD0103) RGFP966 Tubastatin A Ricolinostat (ACY-1215) Quisinostat (JNJ-26481585) 2HCl MC1568 Tubastatin A HCl PCI-34051 Tacedinaline (CI994) LMK-235 Fimepinostat (CUDC-907) Tubacin Givinostat (ITF2357) TMP269 AR-42 Sodium butyrate Pracinostat (SB939) Santacruzamate A (CAY10683) Abexinostat (PCI-24781) (-)-Parthenolide CUDC-101 Dacinostat (LAQ824) CAY10603 RG2833 (RGFP109) Tasquinimod Tucidinostat (Chidamide) TMP195 Nexturastat A Droxinostat Domatinostat (4SC-202) Scriptaid 4-PBA (4-Phenylbutyric acid) M344 Resminostat Citarinostat (ACY-241) BG45 WT161 ACY-738 HPOB ITSA-1 (ITSA1) Tubastatin A TFA TC-H 106 SIS17 ACY-775 BML-210 (CAY10433) TH34 Raddeanin A	もっと見る
関連化合物ライブラリー	Kinase Inhibitor Library FDA-approved Drug Library Natural Product Library Bioactive Compound Library-I Highly Selective Inhibitor Library	もっと見る

シグナル伝達経路

HDACシグナル伝達経路

HDAC阻害剤の選択性比較

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	活性情報	PMID
HCT116	Apoptosis Assay	3 μM	24 h	does not induce apoptosis assessed as increase in p53 protein level	24766560
Jurkat	Cytotoxic Assay	20 μM	72 h	no cytotoxicity assessed as growth inhibition	24304348
MDA-MB-231	Kinase Assay	1 μM	24 h	does not inhibit HDAC6 assessed as acetylation levels of tubulin	23493449
MDA-MB-231	Kinase Assay	10 μM	5 min	does not inhibit HDAC2a	23493449
GM11272	Function Assay	0.1 μM	72 h	does not reactivate MeCp2 mutant expression	21840716
HepG2	Function Assay	10 μM	24 h	does not induce apoptosis assessed as hyperacetylation of p53	21548582
HCT116	Kinase Assay	0.3 μM	30 h	does not inhibit HDAC1 assessed as induction of histone H3K9 acetylation	21080647
A549	Function Assay	5 μM	3 h	does not induce autophagy assessed as increase in LC3II	20855208
SCC4	Function Assay	1 μM	10 min	has no agonist activity at VDR assessed as induction of CYP24 gene expression	20452225
Caco-2	Function Assay	5 μM	24 h	does not induce P21WAF1 gene expression	20143840
PANC1	Function Assay	1 μM	48 h	does not increase in p27kip1 gene expression	17588744
PANC1	Function Assay	1 μM	24 h	does not increase in p27kip1 gene expression	17588744
U937	Kinase Assay	1 μM	24 h	has no effect on alpha tubulin acetylation	17447750
U937	Kinase Assay	5 μM	24 h	has no effect on alpha tubulin acetylation	17447750
GM15850	Function Assay	5 μM	12 h	has no effect on FXN mRNA expression	16921367
GM15850	Kinase Assay	2.5 μM	96 h	does not inhibit HDAC assessed as increase in histone H4 lysine 16 acetylation of FXN gene	16921367
GM15850	Kinase Assay	2.5 μM	96 h	does not inhibit HDAC assessed as increase in histone H4 lysine 8 acetylation of FXN gene	16921367
GM15850	Kinase Assay	2.5 μM	96 h	does not inhibit HDAC assessed as increase in histone H3 lysine 9 acetylation of FXN gene	16921367
GM15850	Kinase Assay	2.5 μM	96 h	does not inhibit HDAC assessed as increase in histone H4 lysine 12 acetylation of FXN gene	16921367
GM15850	Kinase Assay	2.5 μM	96 h	does not inhibit HDAC assessed as increase in histone H4 lysine 5 acetylation of FXN gene	16921367
GM15850	Kinase Assay	2.5 μM	96 h	does not inhibit HDAC assessed as increase in histone H3 lysine 14 acetylation of FXN gene	16921367
Jurkat	Cytotoxic Assay	100 μM	72 h	GI50=0.9 μM	24900743
AsPC1	Growth Inhibition Assay	30 μM	48 h	IC50=3.66 μM	24185378
HL60	Kinase Assay	5 μM	24 h	Inhibition of HDAC	23707260
HGC27	Growth Inhibition Assay	5 μM	72 h	IC50=5.4 μM	23707260
GBC-SD	Growth Inhibition Assay	5 μM	72 h	IC50=14.8 μM	23707260
MEF	Cytotoxic Assay	10 μM	72 h	IC50=4.4 μM	23570542
HS68	Cytotoxic Assay	10 μM	72 h	IC50=4.6 μM	23570542
MDA-MB-231	Kinase Assay	1 μM	24 h	Inhibition of HDAC6 assessed as acetylation levels of tubulin	23493449
MDA-MB-231	Kinase Assay	10 μM	30 min	Inhibition of HDAC2a	23493449
UO31	Growth Inhibition Assay	6.2 μM	72 h	GI50=0.5 μM	22435669
UACC62	Growth Inhibition Assay	6.2 μM	72 h	GI50=0.4 μM	22435669
UACC257	Growth Inhibition Assay	6.2 μM	72 h	GI50=0.5 μM	22435669
TK10	Growth Inhibition Assay	6.2 μM	72 h	GI50=0.63 μM	22435669
T47D	Growth Inhibition Assay	6.2 μM	72 h	GI50=0.5 μM	22435669
SR	Growth Inhibition Assay	6.2 μM	72 h	GI50=0.4 μM	22435669
SNB75	Growth Inhibition Assay	6.2 μM	72 h	GI50=0.79 μM	22435669
SNB19	Growth Inhibition Assay	6.2 μM	72 h	GI50=0.63 μM	22435669
SN12C	Growth Inhibition Assay	6.2 μM	72 h	GI50=2 μM	22435669
SKOV3	Growth Inhibition Assay	6.2 μM	72 h	GI50=1 μM	22435669
SK-MEL-5	Growth Inhibition Assay	6.2 μM	72 h	GI50=0.63 μM	22435669
SK-MEL-28	Growth Inhibition Assay	6.2 μM	72 h	GI50=1 μM	22435669
SK-MEL-2	Growth Inhibition Assay	6.2 μM	72 h	GI50=1.3 μM	22435669
SF539	Growth Inhibition Assay	6.2 μM	72 h	GI50=2 μM	22435669
SF295	Growth Inhibition Assay	6.2 μM	72 h	GI50=1.6 μM	22435669
SF268	Growth Inhibition Assay	6.2 μM	72 h	GI50=1.6 μM	22435669
RXF393	Growth Inhibition Assay	6.2 μM	72 h	GI50=1.3 μM	22435669
OVCAR8	Growth Inhibition Assay	6.2 μM	72 h	GI50=0.5 μM	22435669
OVCAR5	Growth Inhibition Assay	6.2 μM	72 h	GI50=0.79 μM	22435669
OVCAR4	Growth Inhibition Assay	6.2 μM	72 h	GI50=4 μM	22435669
OVCAR3	Growth Inhibition Assay	6.2 μM	72 h	GI50=1.3 μM	22435669
NCI-H522	Growth Inhibition Assay	6.2 μM	72 h	GI50=0.5 μM	22435669
NCI-H460	Growth Inhibition Assay	6.2 μM	72 h	GI50=0.79 μM	22435669
NCI-H322M	Growth Inhibition Assay	6.2 μM	72 h	GI50=0.79 μM	22435669
NCI-H23	Growth Inhibition Assay	6.2 μM	72 h	GI50=1 μM	22435669
NCI-ADR-RES	Growth Inhibition Assay	6.2 μM	72 h	GI50=0.16 μM	22435669
MOLT4	Growth Inhibition Assay	6.2 μM	72 h	GI50=0.4 μM	22435669
MDA-MB-468	Growth Inhibition Assay	6.2 μM	72 h	GI50=0.63 μM	22435669
MDA-MB-435	Growth Inhibition Assay	6.2 μM	72 h	GI50=0.5 μM	22435669
MCF10A	Growth Inhibition Assay	6.2 μM	48 h	GI50=9.6 μM	22435669
MALME-3M	Growth Inhibition Assay	6.2 μM	72 h	GI50=0.32 μM	22435669
M14	Growth Inhibition Assay	6.2 μM	72 h	GI50=1.3 μM	22435669
LOXIMVI	Growth Inhibition Assay	6.2 μM	72 h	GI50=1 μM	22435669
IGROV1	Growth Inhibition Assay	6.2 μM	72 h	GI50=1.3 μM	22435669
HOP92	Growth Inhibition Assay	6.2 μM	72 h	GI50=4 μM	22435669
HCT15	Growth Inhibition Assay	6.2 μM	72 h	GI50=2.5 μM	22435669
EKVX	Growth Inhibition Assay	6.2 μM	72 h	GI50=1.3 μM	22435669
BT549	Growth Inhibition Assay	6.2 μM	72 h	GI50=1.3 μM	22435669
ACHN	Growth Inhibition Assay	6.2 μM	72 h	GI50=1.3 μM	22435669
A549/ATCC	Growth Inhibition Assay	6.2 μM	72 h	GI50=1.6 μM	22435669
A498	Growth Inhibition Assay	6.2 μM	72 h	GI50=1.6 μM	22435669
786-0	Growth Inhibition Assay	6.2 μM	72 h	GI50=3.2 μM	22435669
DU145	Kinase Assay	5 μM	24 h	Inhibition of HDAC assessed as histone H3 hyperacetylation	22260166
DU145	Kinase Assay	5 μM	24 h	Inhibition of HDAC assessed as histone H4 acetylation	22260166
DU145	Kinase Assay	2.5 μM	24 h	Inhibition of HDAC assessed as upregulation of p21waf1 protein expression	22260166
CFBE41o	Function Assay	1 μM	24 h	Restoration of CFTR deltaF508 mutant trafficking to cell surface as glycoforms	21984958
GM11272	Function Assay	100 nM	72 h	Reactivation of MeCp2 mutant expression at 10 to 100 nM	21840716
U937	Kinase Assay	5 μM	15 min	Inhibition of histone acetyltransferase assessed as increase of histone H3 acetylation level	21292492
U937	Kinase Assay	5 μM	24 h	Inhibition of histone acetyltransferase assessed as increase of pan-acetylated histone H4 level	21292492
U937	Kinase Assay	5 μM	24 h	Inhibition of histone acetyltransferase assessed as increase of acetylation of histone H3 at K18	21292492
U937	Kinase Assay	5 μM	24 h	Inhibition of histone acetyltransferase assessed as increase of acetylation of histone H3 at K9	21292492
HCT116	Kinase Assay	30 μM	30 h	Inhibition of HDAC1 assessed as induction of histone H3K9 acetylation	21080647
HCT116	Kinase Assay	30 μM	30 h	Inhibition of HDAC6 assessed as induction of alpha-tubulin acetylation	21080647
MCR5-SV2	Growth Inhibition Assay	10 μM	72 h	GI50=2.1 μM	21080647
LoVo	Growth Inhibition Assay	10 μM	72 h	GI50=1.7 μM	21080647
DU145	Growth Inhibition Assay	10 μM	72 h	GI50=1.05 μM	21080647
COR-L23	Growth Inhibition Assay	10 μM	72 h	GI50=1.1 μM	21080647
A549	Function Assay	5 μM	3 h	Induction of autophagy in human A549 cells assessed as increase in LC3II	20855208
NB4	Kinase Assay	5 μM	24 h	Inhibition of HDAC assessed as increase in histone H3 acetylation	20491440
NB4	Function Assay	5 μM	24 h	Induction of p21WAF1/CIP1 expression	20491440
NB4	Kinase Assay	5 μM	24 h	Inhibition of HDAC assessed as increase in acetylate tubulin level	20491440
NB4	Function Assay	5 μM	24 h	Cell cycle arrest assessed as increase in accumulation at pre-G1 phase	20491440
SCC4	Function Assay	1 μM	5 min	Agonist activity at VDR assessed as induction of CYP24 gene expression	20452225
SCC4	Kinase Assay	1 μM	24h	Inhibition of HDAC assessed as increase in histone acetylation	20452225
SCC4	Kinase Assay	1 μM	24h	Inhibition of HDAC assessed as increase in tubulin acetylation	20452225
COLO205	Kinase Assay	10 μM	24 h	Inhibition of HDAC1 assessed as induction of histone H3 acetylation with IC50 of 2.2 μM	20451378
HepG2	Kinase Assay	5 μM	6h	Induction of HDAC-mediated H3/H4 histone acetylation	20143840
HepG2	Kinase Assay	5 μM	6h	Induction of HDAC-mediated alpha-tubulin acetylation	20143840
HepG2	Kinase Assay	5 μM	6h	Induction of HDAC-mediated histone hyperacetylation	20143840
HepG2	Kinase Assay	5 μM	6h	Induction of HDAC-mediated histone acetylation	20143840
Caco-2	Kinase Assay	0.316 nM to 31.6 μM	4 h	Ex vivo inhibition of human HDAC6	20143840
Caco-2	Kinase Assay	6.32 nM to 632 μM	4 h	Ex vivo inhibition of human HDAC7 with IC50 of 41 μM	20143840
Caco-2	Kinase Assay	6.32 nM to 632 μM	4 h	Ex vivo inhibition of human HDAC5 with IC50 of 12.6 μM	20143840
Caco-2	Kinase Assay	0.316 nM to 31.6 μM	4 h	Ex vivo inhibition of human HDAC3 with IC50 of 0.147 μM	20143840
Caco-2	Kinase Assay	0.316 nM to 31.6 μM	4 h	Ex vivo inhibition of human HDAC1 with IC50 of 0.119 μM	20143840
Caco-2	Kinase Assay	5 μM	4 h	Induction of HDAC-mediated histone acetylation IC50 of 0.037 μM	20143840
Caco-2	Growth Inhibition Assay	100 μM	48h	IC50=8.1 μM	20143840
MUF	Growth Inhibition Assay	100 μM	48 h	Growth inhibition at 0.05 to 100 uM	20143840
BJ	Growth Inhibition Assay	100 μM	48 h	Growth inhibition at 0.05 to 100 uM	20143840
Primary bronchial epithelial cell	Kinase Assay	1 μM	96 h	Inhibition of HDAC7 assessed as increase in short circuit currents	19966789
Primary bronchial epithelial cell	Kinase Assay	5 μM	24 h	Inhibition of HDAC assessed as induction of mutant Fdelta508 CFTR protein apical surface localization	19966789
CFBE41o-	Kinase Assay	5 μM	24 h	Inhibition of HDAC7 assessed as correction of mutant Fdelta508 CFTR trafficking to cell surface as glycoform	19966789
CFBE41o-	Kinase Assay	5 μM	24 h	Inhibition of HDAC7 assessed as increase in stability of Fdelta508 CFTR protein	19966789
CFBE41o-	Kinase Assay	5 μM	24 h	Inhibition of HDAC7 assessed as increase in rate of maturation of CFTR protein to its glycoform	19966789
CFBE41o-	Kinase Assay	1 μM	24 h	Inhibition of HDAC7 assessed as increase in Fdelta508 CFTR protein trafficking	19966789
CFBE41o-	Kinase Assay	1 μM	5 days	Inhibition of HDAC7 assessed as increase in stabilization of Fdelta508 CFTR protein	19966789
Primary bronchial epithelial cell	Kinase Assay	1 μM	24 h	Inhibition of HDAC7 assessed as induction of mutant Fdelta508 CFTR protein apical surface localization	19966789
CFBE41o-	Kinase Assay	1 μM	1 h	Inhibition of HDAC assessed as increase in CFTR protein level	19966789
CFBE41o-	Kinase Assay	5 μM	4 h	Inhibition of HDAC assessed as increase in mutant Fdelta508 CFTR protein level	19966789
CFBE41o-	Kinase Assay	5 μM	8 h	Inhibition of HDAC assessed as hyperacetylation of histone H3	19966789
BHK	Kinase Assay	5 μM	24 h	Inhibition of HDAC7 expressed assessed as increase in plasma membrane Fdelta508 CFTR protein	19966789
SHSY5Y	Cytotoxic Assay	10 μM	48 h	IC50=2 μM	19344175
SHSY5Y	Kinase Assay	10 μM	48 h	Inhibition of HDAC with IC50 of 0.5 μM	19344175
S2	Kinase Assay	0.1-10 μM	1 h	Inhibition of Plasmodium falciparum HDAC1 expressed with IC50 of 0.059 μM	19317450
IGROV1	Kinase Assay	10 μM	4 h	Inhibition of HDAC6 assessed as alpha-tubulin acetylation	19084294
IGROV1	Kinase Assay	10 μM	4 h	Inhibition of HDAC assessed as histone-H4 acetylation	19084294
IGROV1	Kinase Assay	5 μM	24 h	Inhibition of HDAC assessed as p53 acetylation	19084294
HeLa	Kinase Assay	2 μM	30 min	Inhibition of HDAC2 in human HeLa cells with IC50 of 0.1 μM	19084294
HEK293	Function Assay	10 μM	24 h	Activation of mouse Wnt3a signaling expressed	19022675
RAW264.7	Function Assay	2 μM	3.5 h	Antimalarial activity against Plasmodium falciparum infected with IC50 of 0.11 μM	18644969
SU 86.86	Cytotoxic Assay	50 μM	72h	IC50=1.3 μM	18494463
Panc 04.03	Cytotoxic Assay	50 μM	72h	IC50=1.2 μM	18494463
Mia Paca2	Cytotoxic Assay	50 μM	72h	IC50=1.1 μM	18494463
Hup T3	Cytotoxic Assay	50 μM	72h	IC50=0.8 μM	18494463
Human microvascular epithelial cell	Cytotoxic Assay	50 μM	72 h	IC50=1.3 μM	18494463
HPDE6c7	Cytotoxic Assay	50 μM	72 h	IC50=1.3 μM	18494463
HEK-TE	Function Assay	5 μM	6h	Increase in histone H3 acetylation	18434144
U937	Kinase Assay	5 μM	24 h	Inhibition of human HDAC4	18381238
U937	Kinase Assay	5 μM	24 h	Inhibition of human HDAC1	18381238
U937	Function Assay	5 μM	24 h	Induction of granulocytic differentiation	18381238
U937	Function Assay	5 μM	24 h	Induction of apoptosis	18381238
U937	Function Assay	5 μM	24 h	Induction of p21 expression	18381238
U937	Function Assay	5 μM	24 h	Induction of alpha tubulin hyperacetylation	18381238
U937	Function Assay	5 μM	24 h	Induction of histone H4 hyperacetylation	18381238
MCF7	Function Assay	10 μM	8 h	Induction of tubulin hyperacetylation	18269226
NUGC3	Growth Inhibition Assay	5 μM	24 h	GI50=2.79 μM	17904843
HeLa	Kinase Assay	10 μM	30 min	Inhibition of recombinant HDAC1 with IC50 of 0.02 μM	17691763
PANC1	Function Assay	1 μM	24 h	Increase in p27kip1 gene expression	17588744
PANC1	Function Assay	1 μM	24 h	Increase in p21WAF1/CIP1 gene expression	17588744
ST14A	Function Assay	5 nM	72 h	Increase in E2F1 mRNA expression	17565993
ST14A	Function Assay	5 nM	72 h	Increase in REST/NRSF mRNA expression	17565993
RAW264.7	Function Assay	10 μM	24h	Inhibition of LPS-stimulated NO production with IC50 of 1.88 μM	17477518
RAW264.7	Function Assay	10 μM	24h	Inhibition of LPS-stimulated TNFalpha production with IC50 of 0.76 μM	17477518
U937	Function Assay	1 μM	24 h	Effect on alpha tubulin acetylation	17447750
U937	Function Assay	5 μM	24 h	Increase in histone H3 acetylation	17447750
U937	Function Assay	5 μM	24 h	Cell cycle arrest by accumulation at S/G2/M phase	17004718
GM15850	Kinase Assay	2.5 μM	96 h	Inhibition of HDAC assessed as increase in histone H4 lysine 16 acetylation of FXN gene	16921367
GM15850	Kinase Assay	2.5 μM	96 h	Inhibition of HDAC assessed as increase in histone H4 lysine 8 acetylation of FXN gene	16921367
GM15850	Kinase Assay	2.5 μM	96 h	Inhibition of HDAC assessed as increase in histone H3 lysine 9 acetylation of FXN gene	16921367
GM15850	Kinase Assay	2.5 μM	96 h	Inhibition of HDAC assessed as increase in histone H4 lysine 12 acetylation of FXN gene	16921367
GM15850	Kinase Assay	2.5 μM	96 h	Inhibition of HDAC assessed as increase in histone H4 lysine 5 acetylation of FXN gene	16921367
GM15850	Kinase Assay	2.5 μM	96 h	Inhibition of HDAC assessed as increase in histone H3 lysine 14 acetylation of FXN gene	16921367
ARP1	Function Assay	2 μM	6 h	Induction of P21WAF1 gene expression	14734806
Friend leukemic cell	Growth Inhibition Assay	50 μM	72 h	IC50=0.99 μM	12109913
NUGC3	Growth Inhibition Assay	10 μM		GI=2.94 μM	23163332
CFBE41o	Kinase Assay	5 μM		Down regulation of HDAC7 at 0.2 to 5 uM	21984958
PANC1	Growth Inhibition Assay	1 μM		IC50=0.45 μM	17588744
HEK293	Growth Inhibition Assay		72 h	GI50=13 μM	24900500
HL60	Growth Inhibition Assay		72 h	GI50=0.93 μM	24900500
TSGH	Cytotoxic Assay		12 h	IC50=2.09 μM	24766560
MKN45	Cytotoxic Assay		12 h	IC50=1.25 μM	24766560
MONE1	Cytotoxic Assay		12 h	IC50=1.18 μM	24766560
H460	Cytotoxic Assay		12 h	IC50=0.82 μM	24766560
KB	Cytotoxic Assay		12 h	IC50=0.75 μM	24766560
HT-29	Cytotoxic Assay		12 h	IC50=0.72 μM	24766560
HSC3	Cytotoxic Assay		12 h	IC50=0.71 μM	24766560
HEL	Growth Inhibition Assay		48 h	IC50=0.49 μM	24694055
KG1	Growth Inhibition Assay		48 h	IC50=1.15 μM	24525003
Jurkat E6.1	Kinase Assay		2 h	Inhibition of HDAC4 with IC50 of 0.04 μM	24261862
MDA-MB-435	Growth Inhibition Assay		48 h	GI=0.88 μM	24119555
MCF7	Growth Inhibition Assay		48 h	GI=0.45 μM	24119555
MDA-MB-231	Growth Inhibition Assay		48 h	IC50=0.16 μM	24095016
Hs578T	Cytotoxic Assay		48 h	GI=4.83 μM	24015327
KM12	Cytotoxic Assay		48 h	GI=1.88 μM	24015327
U251	Cytotoxic Assay		48 h	GI=1.53 μM	24015327
SW620	Cytotoxic Assay		48 h	GI=0.54 μM	24015327
NCI60	Cytotoxic Assay		48 h	GI=0.53 μM	24015327
Vero	Growth Inhibition Assay		72 h	IC50=0.9 μM	23786452
High5	Kinase Assay		24 h	Inhibition of human recombinant HDAC3 with IC50 of 0.17 μM	23602523
High5	Kinase Assay		24 h	Inhibition of human recombinant HDAC1 with IC50 of 0.12 μM	23602523
High5	Kinase Assay		24 h	Inhibition of human recombinant HDAC6 with IC50 of 0.09 μM	23602523
ES2	Growth Inhibition Assay		48 h	IC50=12.7 μM	23493449
MDA-MB-231 CisR	Kinase Assay		18 h	Inhibition of HDAC with IC50 of 0.61 μM	23252603
MDA-MB-231 sens	Kinase Assay		18 h	Inhibition of HDAC with IC50 of 0.61 μM	23252603
KYSE-510 sens	Kinase Assay		18 h	Inhibition of HDAC with IC50 of 0.7 μM	23252603
KYSE-510 CisR	Kinase Assay		18 h	Inhibition of HDAC with IC50 of 0.59 μM	23252603
CAL27 CisR	Kinase Assay		18 h	Inhibition of HDAC with IC50 of 0.61 μM	23252603
CAL27 sens	Kinase Assay		18 h	Inhibition of HDAC with IC50 of 0.36 μM	23252603
A2780 CisR	Kinase Assay		18 h	Inhibition of HDAC with IC50 of 0.44 μM	23252603
SMMC7721	Growth Inhibition Assay		72 h	GI90=20 μM	23061376
SKHEP1	Growth Inhibition Assay		72 h	GI90=17 μM	23061376
SGC7901	Growth Inhibition Assay		72 h	GI90=9.4 μM	23061376
MGC803	Growth Inhibition Assay		72 h	GI90=10.8 μM	23061376
BGC823	Growth Inhibition Assay		72 h	GI90=7.5 μM	23061376
Bel7404	Growth Inhibition Assay		72 h	GI90=18 μM	23061376
Bel7402	Growth Inhibition Assay		72 h	GI90=17 μM	23061376
BE(2)-C	Growth Inhibition Assay		72 h	IC70=2 μM	22932316
Hep3B	Growth Inhibition Assay		48 h	GI50=0.69 μM	22439863
Hep3B	Growth Inhibition Assay		48 h	GI50=1.21 μM	21712146
COLO205	Growth Inhibition Assay		96 h	IC50=2.12 μM	21634430
A2780	Growth Inhibition Assay		96 h	IC50=1.62 μM	21634430
SKOV3	Cytotoxic Assay		72 h	Cytotoxicity against human SKOV3 cells overexpressing HER2 with IC50 of 2.2 μM	21080629
SKBR3	Cytotoxic Assay		72 h	Cytotoxicity against human SKBR3 cells overexpressing HER2 with IC50 of 2.6 μM	21080629
Sf21	Kinase Assay		3 h	Inhibition of Flag tagged human recombinant HDAC8 expressed with IC50 of 1.2 μM	21080629
HeLa	Cytotoxic Assay		72 h	Cytotoxicity against human HeLa cells overexpressing HDAC with IC50 of 1.5 μM	21080629
CAL27	Cytotoxic Assay		72 h	Cytotoxicity against human CAL27 cells overexpressing EGFR with IC50 of 3.2 μM	21080629
A549	Cytotoxic Assay		72 h	Cytotoxicity against human A549 cells overexpressing HDAC with IC50 of 1.8 μM	21080629
A431	Cytotoxic Assay		72 h	Cytotoxicity against human A431 cells overexpressing EGFR with IC50 of 4.2 μM	21080629
U937	Growth Inhibition Assay		72 h	GI50=0.39 μM	20884208
HUT78	Growth Inhibition Assay		72 h	GI50=0.3 μM	20884208
SKHEP1	Growth Inhibition Assay		72 h	IC50=3.46 μM	20143778
SCC25	Growth Inhibition Assay		72 h	IC50=1.93 μM	20143778
SCC15	Growth Inhibition Assay		72 h	IC50=2.49 μM	20143778
NCI-H358	Growth Inhibition Assay		72 h	IC50=2.5 μM	20143778
NCI-H2122	Growth Inhibition Assay		72 h	IC50=7.5 μM	20143778
LNCAP	Growth Inhibition Assay		72 h	IC50=0.58 μM	20143778
HCC827	Growth Inhibition Assay		72 h	IC50=1.8 μM	20143778
Capan1	Growth Inhibition Assay		72 h	IC50=7.3 μM	20143778
CAL27	Growth Inhibition Assay		72 h	IC50=3.72 μM	20143778
BxPC3	Growth Inhibition Assay		72 h	IC50=2.7 μM	20143778
HeLa	Growth Inhibition Assay		72 h	IC50=0.46 μM	19441846
SNB78	Growth Inhibition Assay		48 h	GI50=16 μM	19419205
HBC5	Growth Inhibition Assay		48 h	GI50=17 μM	19419205
DMS114	Growth Inhibition Assay		48 h	GI50=2.9 μM	19419205
SKMES1	Cytotoxic Assay		72 h	IC50=2.42 μM	19093884
NCI-H69	Cytotoxic Assay		72 h	IC50=2.06 μM	19093884
HeLa	Kinase Assay		15 min	Inhibition of HDAC8 from nuclear extract with IC50 of 1.86 μM	19093884
HeLa	Kinase Assay		15 min	Inhibition of HDAC6 from nuclear extract with IC50 of 0.0855 μM	19093884
T24	Kinase Assay		3 h	Induction of alpha tubulin acetylation with EC50 of 0.25 μM	19084395
T24	Kinase Assay		3 h	Induction of histone H3 acetylation with EC50 of 0.12 μM	19084395
IGROV1	Growth Inhibition Assay		72 h	IC50=2.2 μM	19084294
HCT116	Growth Inhibition Assay		72h	IC50=0.31 μM	19084294
NB4			48h	IC50=0.6 μM	18723349
HeLa	Kinase Assay		2 h	Inhibition of nuclear HDAC with IC50 of 0.083 μM	18558669
HEK293	Kinase Assay		3 h	Inhibition of recombinant HDAC6 expression with IC50 of 0.019 μM	18558669
Human renal epithelial cell	Growth Inhibition Assay		72 h	IC50=14 μM	18370373
HeLa	Growth Inhibition Assay		72 h	IC50=0.46 μM	18370373
G401	Growth Inhibition Assay		72 h	IC50=1 μM	18370373
HEK293	Kinase Assay		1 h	Inhibition of HDAC3 with IC50 of 0.057 μM	18308563
HEK293	Kinase Assay		1 h	Inhibition of HDAC1 with IC50 of 0.03 μM	18308563
U87MG	Cytotoxic Assay		72 h	IC50=11 μM	17691763
SK-OV-3	Cytotoxic Assay		72 h	IC50=2.2 μM	17691763
Saos2	Cytotoxic Assay		72 h	IC50=2.3 μM	17691763
RKOp21	Cytotoxic Assay		72 h	IC50=1.76 μM	17691763
Hec-1-A	Cytotoxic Assay		72 h	IC50=1 μM	17691763
EOL1	Cytotoxic Assay		72 h	IC50=1 μM	17691763
CCRF-CEM	Cytotoxic Assay		72 h	IC50=0.8 μM	17691763
Cal27	Cytotoxic Assay		72 h	IC50=3.2 μM	17691763
A431	Cytotoxic Assay		72 h	IC50=4.2 μM	17691763
PC3	Growth Inhibition Assay		21 h	GI50=0.71 μM	17662606
ACHN	Growth Inhibition Assay		21 h	GI50=0.65 μM	17662606
SC9	Growth Inhibition Assay		48 h	IC50=0.606 μM	17507219
H661	Growth Inhibition Assay		48 h	IC50=1 μM	17157009
NCI-H23	Growth Inhibition Assay		48 h	GI50=0.92 μM	16723227
HCT15	Growth Inhibition Assay		48 h	GI50=0.82 μM	16723227
CEM	Kinase Assay		1 h	Inhibition of HDAC with IC50 of 0.33 μM	16420064
St-4	Growth Inhibition Assay		48 h	IC50=5.2 μM	15715470
SNB-78	Growth Inhibition Assay		48 h	IC50=16 μM	15715470
RXF-631L	Growth Inhibition Assay		48 h	IC50=2 μM	15715470
NCI-H226	Growth Inhibition Assay		48 h	IC50=2.6 μM	15715470
LOX-IMVI	Growth Inhibition Assay		48 h	IC50=1.3 μM	15715470
HeLa	Kinase Assay		30 min	Inhibitory concentration against histone deacetylase with IC50 of 0.28 μM	15603949
H1299	Growth Inhibition Assay		72 h	IC50=7.24 μM	14521422
A20	Kinase Assay		1 h	anti-HDAC1 activity with IC50 of 0.112 μM	11960489
K562	Kinase Assay		6 h	Inhibition of human histone deacetylase (mixture of HDAC1 and HDAC2) with IC50 of 0.01 μM	12419380
HT1080	Growth Inhibition Assay		72 h	IC50=2.4 μM	12270175
H1299	Kinase Assay		20 min	Inhibitory activity against HDAC enzyme with IC50 of 0.194 μM	14521422
ECC10	Growth Inhibition Assay			IC50=945.87 nM	SANGER
A427	Growth Inhibition Assay			IC50=920.84 nM	SANGER
J-RT3-T3-5	Growth Inhibition Assay			IC50=910.49 nM	SANGER
SK-N-DZ	Growth Inhibition Assay			IC50=900.43 nM	SANGER
KE-37	Growth Inhibition Assay			IC50=894.62 nM	SANGER
HH	Growth Inhibition Assay			IC50=894.12 nM	SANGER
HGC-27	Growth Inhibition Assay			IC50=872.34 nM	SANGER
SW954	Growth Inhibition Assay			IC50=863.16 nM	SANGER
QIMR-WIL	Growth Inhibition Assay			IC50=862.03 nM	SANGER
HSC-4	Growth Inhibition Assay			IC50=846.51 nM	SANGER
D-566MG	Growth Inhibition Assay			IC50=838.62 nM	SANGER
P30-OHK	Growth Inhibition Assay			IC50=835.7 nM	SANGER
EW-18	Growth Inhibition Assay			IC50=832.96 nM	SANGER
RS4-11	Growth Inhibition Assay			IC50=832.45 nM	SANGER
LU-139	Growth Inhibition Assay			IC50=822.86 nM	SANGER
ALL-PO	Growth Inhibition Assay			IC50=814.66 nM	SANGER
RPMI-8866	Growth Inhibition Assay			IC50=813.67 nM	SANGER
KU812	Growth Inhibition Assay			IC50=813.1 nM	SANGER
SK-MEL-2	Growth Inhibition Assay			IC50=809.44 nM	SANGER
HEL	Growth Inhibition Assay			IC50=806.08 nM	SANGER
SBC-1	Growth Inhibition Assay			IC50=793.84 nM	SANGER
TE-1	Growth Inhibition Assay			IC50=791.1 nM	SANGER
MOLT-4	Growth Inhibition Assay			IC50=787.46 nM	SANGER
KG-1	Growth Inhibition Assay			IC50=775.45 nM	SANGER
NB10	Growth Inhibition Assay			IC50=751.92 nM	SANGER
DU-4475	Growth Inhibition Assay			IC50=751.91 nM	SANGER
ATN-1	Growth Inhibition Assay			IC50=740.28 nM	SANGER
MOLT-13	Growth Inhibition Assay			IC50=738.98 nM	SANGER
NCI-H209	Growth Inhibition Assay			IC50=729.9 nM	SANGER
GOTO	Growth Inhibition Assay			IC50=729.12 nM	SANGER
ES1	Growth Inhibition Assay			IC50=724.4 nM	SANGER
D-283MED	Growth Inhibition Assay			IC50=714.14 nM	SANGER
D-423MG	Growth Inhibition Assay			IC50=706.89 nM	SANGER
DOHH-2	Growth Inhibition Assay			IC50=706.68 nM	SANGER
NB14	Growth Inhibition Assay			IC50=696.95 nM	SANGER
RPMI-8226	Growth Inhibition Assay			IC50=678.18 nM	SANGER
MV-4-11	Growth Inhibition Assay			IC50=659.1 nM	SANGER
A4-Fuk	Growth Inhibition Assay			IC50=644.91 nM	SANGER
CHL-1	Growth Inhibition Assay			IC50=642.08 nM	SANGER
DB	Growth Inhibition Assay			IC50=598.57 nM	SANGER
P12-ICHIKAWA	Growth Inhibition Assay			IC50=596.51 nM	SANGER
CTV-1	Growth Inhibition Assay			IC50=581.56 nM	SANGER
OVCAR-5	Growth Inhibition Assay			IC50=576.11 nM	SANGER
KY821	Growth Inhibition Assay			IC50=563.25 nM	SANGER
NCI-H720	Growth Inhibition Assay			IC50=560.18 nM	SANGER
NKM-1	Growth Inhibition Assay			IC50=544.27 nM	SANGER
HD-MY-Z	Growth Inhibition Assay			IC50=538.13 nM	SANGER
CTB-1	Growth Inhibition Assay			IC50=537.92 nM	SANGER
BE-13	Growth Inhibition Assay			IC50=526.96 nM	SANGER
ES8	Growth Inhibition Assay			IC50=523.53 nM	SANGER
L-363	Growth Inhibition Assay			IC50=503.1 nM	SANGER
BCPAP	Growth Inhibition Assay			IC50=501.42 nM	SANGER
697	Growth Inhibition Assay			IC50=473.41 nM	SANGER
C2BBe1	Growth Inhibition Assay			IC50=472.19 nM	SANGER
CHP-212	Growth Inhibition Assay			IC50=457.53 nM	SANGER
EoL-1-cell	Growth Inhibition Assay			IC50=45425 nM	SANGER
NB69	Growth Inhibition Assay			IC50=411.71 nM	SANGER
A3-KAW	Growth Inhibition Assay			IC50=400.59 nM	SANGER
NB7	Growth Inhibition Assay			IC50=345.74 nM	SANGER
MHH-PREB-1	Growth Inhibition Assay			IC50=294.53 nM	SANGER
NEC8	Growth Inhibition Assay			IC50=289.38 nM	SANGER
PA-1	Growth Inhibition Assay			IC50=286.26 nM	SANGER
H9	Growth Inhibition Assay			IC50=255.04 nM	SANGER
BHT-101	Growth Inhibition Assay			IC50=244.18 nM	SANGER
KARPAS-45	Growth Inhibition Assay			IC50=173.89 nM	SANGER
KASUMI-1	Growth Inhibition Assay			IC50=99.17 nM	SANGER
K562	Kinase Assay			does not inhibit HDAC	23591111
K562	Growth Inhibition Assay			IC50=0.645 μM	23644210
HCT116	Growth Inhibition Assay			IC50=0.757 μM	23644210
A549	Growth Inhibition Assay			IC50=1.079 μM	23644210
BGC823	Growth Inhibition Assay			GI50=3.09 μM	23601706
NUGC3	Growth Inhibition Assay			GI50=2.94 μM	20850971
St4	Growth Inhibition Assay			EC50=5.2 μM	18247554
SQ20B	Growth Inhibition Assay			IC50=3 μM	18247554
SNB78	Growth Inhibition Assay			EC50=16 μM	18247554
SKBR3	Growth Inhibition Assay			IC50=0.8 μM	18247554
HT1080	Growth Inhibition Assay			IC50=0.0024 μM	18247554
HepG2	Growth Inhibition Assay			IC50=0.0006 μM	18247554
CCD1059SK	Growth Inhibition Assay			IC50=43.5 μM	18247554
PT45	Growth Inhibition Assay			IC50=4 μM	17588744
EW-1	Growth Inhibition Assay			IC50=947.26 nM	SANGER
MIA-PaCa-2	Growth Inhibition Assay			IC50=949.12 nM	SANGER
HCC2218	Growth Inhibition Assay			IC50=958.48 nM	SANGER
HAL-01	Growth Inhibition Assay			IC50=968.04 nM	SANGER
RD	Growth Inhibition Assay			IC50=974.45 nM	SANGER
SK-N-AS	Growth Inhibition Assay			IC50=988.1 nM	SANGER
ML-2	Growth Inhibition Assay			IC50=1.00407 μM	SANGER
MEL-HO	Growth Inhibition Assay			IC50=1.00582 μM	SANGER
MS-1	Growth Inhibition Assay			IC50=1.00617 μM	SANGER
NCI-SNU-1	Growth Inhibition Assay			IC50=1.02331 μM	SANGER
8505C	Growth Inhibition Assay			IC50=1.02331 μM	SANGER
MN-60	Growth Inhibition Assay			IC50=1.0268 μM	SANGER
SAS	Growth Inhibition Assay			IC50=1.04081 μM	SANGER
EFM-19	Growth Inhibition Assay			IC50=1.04879 μM	SANGER
Ca9-22	Growth Inhibition Assay			IC50=1.05107 μM	SANGER
NBsusSR	Growth Inhibition Assay			IC50=1.05166 μM	SANGER
NB13	Growth Inhibition Assay			IC50=1.05501 μM	SANGER
SF295	Growth Inhibition Assay			IC50=1.06624 μM	SANGER
U-2-OS	Growth Inhibition Assay			IC50=1.07911 μM	SANGER
NCI-H526	Growth Inhibition Assay			IC50=1.08291 μM	SANGER
KMOE-2	Growth Inhibition Assay			IC50=1.09422 μM	SANGER
RCM-1	Growth Inhibition Assay			IC50=1.12102 μM	SANGER
MC116	Growth Inhibition Assay			IC50=1.13621 μM	SANGER
NCI-H1092	Growth Inhibition Assay			IC50=1.15406 μM	SANGER
EW-3	Growth Inhibition Assay			IC50=1.17212 μM	SANGER
HCT-116	Growth Inhibition Assay			IC50=1.1775 μM	SANGER
MC-IXC	Growth Inhibition Assay			IC50=1.17881 μM	SANGER
LB1047-RCC	Growth Inhibition Assay			IC50=1.18312 μM	SANGER
VM-CUB-1	Growth Inhibition Assay			IC50=1.19108 μM	SANGER
NB5	Growth Inhibition Assay			IC50=1.19856 μM	SANGER
SKG-IIIa	Growth Inhibition Assay			IC50=1.23464 μM	SANGER
HO-1-N-1	Growth Inhibition Assay			IC50=1.23835 μM	SANGER
EFO-27	Growth Inhibition Assay			IC50=1.25043 μM	SANGER
MHH-NB-11	Growth Inhibition Assay			IC50=1.28329 μM	SANGER
SW620	Growth Inhibition Assay			IC50=1.29018 μM	SANGER
MOLT-16	Growth Inhibition Assay			IC50=1.29797 μM	SANGER
NTERA-S-cl-D1	Growth Inhibition Assay			IC50=1.31761 μM	SANGER
VA-ES-BJ	Growth Inhibition Assay			IC50=1.32477 μM	SANGER
HCC1419	Growth Inhibition Assay			IC50=1.34027 μM	SANGER
NCI-H69	Growth Inhibition Assay			IC50=1.34112 μM	SANGER
DEL	Growth Inhibition Assay			IC50=1.35162 μM	SANGER
LXF-289	Growth Inhibition Assay			IC50=1.3524 μM	SANGER
EW-11	Growth Inhibition Assay			IC50=1.36026 μM	SANGER
KP-4	Growth Inhibition Assay			IC50=1.37085 μM	SANGER
NOS-1	Growth Inhibition Assay			IC50=1.41194 μM	SANGER
SK-NEP-1	Growth Inhibition Assay			IC50=1.41693 μM	SANGER
LAMA-84	Growth Inhibition Assay			IC50=1.43945 μM	SANGER
ES5	Growth Inhibition Assay			IC50=1.443 μM	SANGER
HuO9	Growth Inhibition Assay			IC50=1.45362 μM	SANGER
COLO-684	Growth Inhibition Assay			IC50=1.46118 μM	SANGER
EW-24	Growth Inhibition Assay			IC50=1.46531 μM	SANGER
BV-173	Growth Inhibition Assay			IC50=1.47291 μM	SANGER
NCI-H1770	Growth Inhibition Assay			IC50=1.48536 μM	SANGER
HuP-T4	Growth Inhibition Assay			IC50=1.493 μM	SANGER
TYK-nu	Growth Inhibition Assay			IC50=1.49851 μM	SANGER
YH-13	Growth Inhibition Assay			IC50=1.49894 μM	SANGER
H4	Growth Inhibition Assay			IC50=1.50912 μM	SANGER
OVCAR-8	Growth Inhibition Assay			IC50=1.54477 μM	SANGER
NCI-H23	Growth Inhibition Assay			IC50=1.54645 μM	SANGER
ES7	Growth Inhibition Assay			IC50=1.54773 μM	SANGER
COR-L88	Growth Inhibition Assay			IC50=1.56424 μM	SANGER
TI-73	Growth Inhibition Assay			IC50=1.5906 μM	SANGER
RT-112	Growth Inhibition Assay			IC50=1.59284 μM	SANGER
HuO-3N1	Growth Inhibition Assay			IC50=1.59385 μM	SANGER
HC-1	Growth Inhibition Assay			IC50=1.59866 μM	SANGER
HT55	Growth Inhibition Assay			IC50=1.65131 μM	SANGER
IA-LM	Growth Inhibition Assay			IC50=1.69278 μM	SANGER
EM-2	Growth Inhibition Assay			IC50=1.70014 μM	SANGER
MHH-ES-1	Growth Inhibition Assay			IC50=1.70435 μM	SANGER
CAL-27	Growth Inhibition Assay			IC50=1.70621 μM	SANGER
COLO-800	Growth Inhibition Assay			IC50=1.71179 μM	SANGER
HCE-T	Growth Inhibition Assay			IC50=1.715 μM	SANGER
CAMA-1	Growth Inhibition Assay			IC50=1.71971 μM	SANGER
LOXIMVI	Growth Inhibition Assay			IC50=1.7211 μM	SANGER
NH-12	Growth Inhibition Assay			IC50=1.72691 μM	SANGER
TCCSUP	Growth Inhibition Assay			IC50=1.72829 μM	SANGER
MDA-MB-361	Growth Inhibition Assay			IC50=1.73157 μM	SANGER
EW-16	Growth Inhibition Assay			IC50=1.74107 μM	SANGER
SNU-423	Growth Inhibition Assay			IC50=1.75827 μM	SANGER
Daoy	Growth Inhibition Assay			IC50=1.76319 μM	SANGER
ES4	Growth Inhibition Assay			IC50=1.78741 μM	SANGER
PFSK-1	Growth Inhibition Assay			IC50=1.8037 μM	SANGER
ES3	Growth Inhibition Assay			IC50=1.82681 μM	SANGER
ONS-76	Growth Inhibition Assay			IC50=1.82897 μM	SANGER
JVM-3	Growth Inhibition Assay			IC50=1.85451 μM	SANGER
OS-RC-2	Growth Inhibition Assay			IC50=1.87151 μM	SANGER
COLO-320-HSR	Growth Inhibition Assay			IC50=1.88197 μM	SANGER
HN	Growth Inhibition Assay			IC50=1.88725 μM	SANGER
HT	Growth Inhibition Assay			IC50=1.88947 μM	SANGER
LoVo	Growth Inhibition Assay			IC50=1.8981 μM	SANGER
CGTH-W-1	Growth Inhibition Assay			IC50=1.89946 μM	SANGER
NB6	Growth Inhibition Assay			IC50=1.91298 μM	SANGER
EW-22	Growth Inhibition Assay			IC50=1.92887 μM	SANGER
ES6	Growth Inhibition Assay			IC50=1.93631 μM	SANGER
SCC-15	Growth Inhibition Assay			IC50=1.93819 μM	SANGER
HL-60	Growth Inhibition Assay			IC50=1.93902 μM	SANGER
human HOP-92	Growth Inhibition Assay			IC50=1.94065 μM	SANGER
SW626	Growth Inhibition Assay			IC50=1.94899 μM	SANGER
HEC-1	Growth Inhibition Assay			IC50=1.9536 μM	SANGER
LB2241-RCC	Growth Inhibition Assay			IC50=1.98231 μM	SANGER
Ramos-2G6-4C10	Growth Inhibition Assay			IC50=1.99493 μM	SANGER
A101D	Growth Inhibition Assay			IC50=2.20303 μM	SANGER
NCI-H446	Growth Inhibition Assay			IC50=2.04599 μM	SANGER
SBC-5	Growth Inhibition Assay			IC50=2.06147 μM	SANGER
HOS	Growth Inhibition Assay			IC50=2.07653 μM	SANGER
K5	Growth Inhibition Assay			IC50=2.07811 μM	SANGER
HLE	Growth Inhibition Assay			IC50=2.08529 μM	SANGER
HSC-2	Growth Inhibition Assay			IC50=2.12898 μM	SANGER
LCLC-97TM1	Growth Inhibition Assay			IC50=2.14583 μM	SANGER
DMS-273	Growth Inhibition Assay			IC50=2.14837 μM	SANGER
TE-8	Growth Inhibition Assay			IC50=2.15765 μM	SANGER
DSH1	Growth Inhibition Assay			IC50=2.16398 μM	SANGER
CAL-51	Growth Inhibition Assay			IC50=2.16699 μM	SANGER
IST-SL1	Growth Inhibition Assay			IC50=2.16844 μM	SANGER
GCT	Growth Inhibition Assay			IC50=2.1777 μM	SANGER
SW948	Growth Inhibition Assay			IC50=2.18456 μM	SANGER
NOMO-1	Growth Inhibition Assay			IC50=2.19317 μM	SANGER
C8166	Growth Inhibition Assay			IC50=2.21334 μM	SANGER
OC-314	Growth Inhibition Assay			IC50=2.23259 μM	SANGER
CAL-39	Growth Inhibition Assay			IC50=2.23626 μM	SANGER
MDA-MB-453	Growth Inhibition Assay			IC50=2.24275 μM	SANGER
A673	Growth Inhibition Assay			IC50=2.25862 μM	SANGER
HTC-C3	Growth Inhibition Assay			IC50=2.2685 μM	SANGER
NCI-H1666	Growth Inhibition Assay			IC50=2.28111 μM	SANGER
PSN1	Growth Inhibition Assay			IC50=2.28913 μM	SANGER
GI-1	Growth Inhibition Assay			IC50=2.30543 μM	SANGER
HuH-7	Growth Inhibition Assay			IC50=2.30637 μM	SANGER
JAR	Growth Inhibition Assay			IC50=2.31987 μM	SANGER
5637	Growth Inhibition Assay			IC50=2.32129 μM	SANGER
GB-1	Growth Inhibition Assay			IC50=2.32335 μM	SANGER
KP-N-YS	Growth Inhibition Assay			IC50=2.32615 μM	SANGER
OAW-42	Growth Inhibition Assay			IC50=2.33416 μM	SANGER
8-MG-BA	Growth Inhibition Assay			IC50=2.33906 μM	SANGER
RH-18	Growth Inhibition Assay			IC50=2.35022 μM	SANGER
NCI-H1155	Growth Inhibition Assay			IC50=2.36725 μM	SANGER
NB17	Growth Inhibition Assay			IC50=2.38243 μM	SANGER
NCI-H1437	Growth Inhibition Assay			IC50=2.41873 μM	SANGER
SN12C	Growth Inhibition Assay			IC50=2.43214 μM	SANGER
HSC-3	Growth Inhibition Assay			IC50=2.44509 μM	SANGER
GAMG	Growth Inhibition Assay			IC50=2.44561 μM	SANGER
HT-1080	Growth Inhibition Assay			IC50=2.44864 μM	SANGER
A549	Growth Inhibition Assay			IC50=2.44893 μM	SANGER
KNS-62	Growth Inhibition Assay			IC50=2.45061 μM	SANGER
YKG-1	Growth Inhibition Assay			IC50=2.45437 μM	SANGER
LU-134-A	Growth Inhibition Assay			IC50=2.47008 μM	SANGER
FADU	Growth Inhibition Assay			IC50=2.47162 μM	SANGER
TGBC11TKB	Growth Inhibition Assay			IC50=2.47177 μM	SANGER
HT-3	Growth Inhibition Assay			IC50=2.49535 μM	SANGER
NCI-H2170	Growth Inhibition Assay			IC50=2.50549 μM	SANGER
Mo-T	Growth Inhibition Assay			IC50=2.50927 μM	SANGER
CCRF-CEM	Growth Inhibition Assay			IC50=2.53043 μM	SANGER
KU-19-19	Growth Inhibition Assay			IC50=2.53513 μM	SANGER
NCI-H1048	Growth Inhibition Assay			IC50=2.55025 μM	SANGER
KOSC-2	Growth Inhibition Assay			IC50=2.56076 μM	SANGER
A431	Growth Inhibition Assay			IC50=2.56335 μM	SANGER
COR-L23	Growth Inhibition Assay			IC50=2.58566 μM	SANGER
MKN28	Growth Inhibition Assay			IC50=2.59037 μM	SANGER
22RV1	Growth Inhibition Assay			IC50=2.59274 μM	SANGER
ABC-1	Growth Inhibition Assay			IC50=2.6046 μM	SANGER
NCI-H2126	Growth Inhibition Assay			IC50=2.60984 μM	SANGER
DoTc2-4510	Growth Inhibition Assay			IC50=2.62185 μM	SANGER
SCC-4	Growth Inhibition Assay			IC50=2.63012 μM	SANGER
NCI-H661	Growth Inhibition Assay			IC50=2.64085 μM	SANGER
RPMI-2650	Growth Inhibition Assay			IC50=2.64143 μM	SANGER
NCI-H510A	Growth Inhibition Assay			IC50=2.64426 μM	SANGER
BPH-1	Growth Inhibition Assay			IC50=2.6585 μM	SANGER
M14	Growth Inhibition Assay			IC50=2.66993 μM	SANGER
G-402	Growth Inhibition Assay			IC50=2.70451 μM	SANGER
AsPC-1	Growth Inhibition Assay			IC50=2.7117 μM	SANGER
NB12	Growth Inhibition Assay			IC50=2.7171 μM	SANGER
SK-HEP-1	Growth Inhibition Assay			IC50=2.74391 μM	SANGER
U-266	Growth Inhibition Assay			IC50=2.77121 μM	SANGER
AM-38	Growth Inhibition Assay			IC50=2.77355 μM	SANGER
PC-14	Growth Inhibition Assay			IC50=2.8051 μM	SANGER
EGI-1	Growth Inhibition Assay			IC50=2.81743 μM	SANGER
LS-411N	Growth Inhibition Assay			IC50=2.8233 μM	SANGER
BFTC-905	Growth Inhibition Assay			IC50=2.85523 μM	SANGER
CaR-1	Growth Inhibition Assay			IC50=2.86 μM	SANGER
NCI-H292	Growth Inhibition Assay			IC50=2.86596 μM	SANGER
8305C	Growth Inhibition Assay			IC50=2.86645 μM	SANGER
SNU-449	Growth Inhibition Assay			IC50=2.89182 μM	SANGER
LCLC-103H	Growth Inhibition Assay			IC50=2.90438 μM	SANGER
SW1573	Growth Inhibition Assay			IC50=2.96082 μM	SANGER
MLMA	Growth Inhibition Assay			IC50=2.96717 μM	SANGER
NCI-H1355	Growth Inhibition Assay			IC50=3.00796 μM	SANGER
RMG-I	Growth Inhibition Assay			IC50=3.02592 μM	SANGER
BB65-RCC	Growth Inhibition Assay			IC50=3.03314 μM	SANGER
PC-3	Growth Inhibition Assay			IC50=3.03874 μM	SANGER
SF268	Growth Inhibition Assay			IC50=3.04523 μM	SANGER
NCI-H810	Growth Inhibition Assay			IC50=3.04823 μM	SANGER
MEG-01	Growth Inhibition Assay			IC50=3.06164 μM	SANGER
SW13	Growth Inhibition Assay			IC50=3.07847 μM	SANGER
RH-1	Growth Inhibition Assay			IC50=3.10278 μM	SANGER
GT3TKB	Growth Inhibition Assay			IC50=3.11283 μM	SANGER
TK10	Growth Inhibition Assay			IC50=3.13724 μM	SANGER
T-24	Growth Inhibition Assay			IC50=3.1507 μM	SANGER
A498	Growth Inhibition Assay			IC50=3.20871 μM	SANGER
GR-ST	Growth Inhibition Assay			IC50=3.22139 μM	SANGER
LB2518-MEL	Growth Inhibition Assay			IC50=3.22398 μM	SANGER
T47D	Growth Inhibition Assay			IC50=3.23627 μM	SANGER
NCI-H1651	Growth Inhibition Assay			IC50=3.24644 μM	SANGER
EC-GI-10	Growth Inhibition Assay			IC50=3.26153 μM	SANGER
HT-29	Growth Inhibition Assay			IC50=3.26614 μM	SANGER
GI-ME-N	Growth Inhibition Assay			IC50=3.29511 μM	SANGER
SW756	Growth Inhibition Assay			IC50=3.29629 μM	SANGER
RKO	Growth Inhibition Assay			IC50=3.30757 μM	SANGER
NCI-H1563	Growth Inhibition Assay			IC50=3.33018 μM	SANGER
DJM-1	Growth Inhibition Assay			IC50=3.37674 μM	SANGER
L-428	Growth Inhibition Assay			IC50=3.40045 μM	SANGER
NCI-H2122	Growth Inhibition Assay			IC50=3.41312 μM	SANGER
Ca-Ski	Growth Inhibition Assay			IC50=3.4543 μM	SANGER
639-V	Growth Inhibition Assay			IC50=3.46057 μM	SANGER
SW1116	Growth Inhibition Assay			IC50=3.46269 μM	SANGER
DMS-114	Growth Inhibition Assay			IC50=3.47066 μM	SANGER
MZ2-MEL	Growth Inhibition Assay			IC50=3.47681 μM	SANGER
COLO-829	Growth Inhibition Assay			IC50=3.50073 μM	SANGER
J82	Growth Inhibition Assay			IC50=3.5057 μM	SANGER
EW-13	Growth Inhibition Assay			IC50=3.5251 μM	SANGER
RXF393	Growth Inhibition Assay			IC50=3.53294 μM	SANGER
CAL-62	Growth Inhibition Assay			IC50=3.54514 μM	SANGER
OCUB-M	Growth Inhibition Assay			IC50=3.54665 μM	SANGER
BT-474	Growth Inhibition Assay			IC50=3.6331 μM	SANGER
KYSE-180	Growth Inhibition Assay			IC50=3.63372 μM	SANGER
NCI-H650	Growth Inhibition Assay			IC50=3.64287 μM	SANGER
Detroit562	Growth Inhibition Assay			IC50=3.65022 μM	SANGER
SW48	Growth Inhibition Assay			IC50=3.65657 μM	SANGER
KYSE-450	Growth Inhibition Assay			IC50=3.68582 μM	SANGER
KYSE-510	Growth Inhibition Assay			IC50=3.72181 μM	SANGER
GP5d	Growth Inhibition Assay			IC50=3.7295 μM	SANGER
RPMI-7951	Growth Inhibition Assay			IC50=3.74723 μM	SANGER
Becker	Growth Inhibition Assay			IC50=3.75012 μM	SANGER
WM-115	Growth Inhibition Assay			IC50=3.78195 μM	SANGER
G-401	Growth Inhibition Assay			IC50=3.79085 μM	SANGER
PANC-08-13	Growth Inhibition Assay			IC50=3.79602 μM	SANGER
SW982	Growth Inhibition Assay			IC50=3.80551 μM	SANGER
D-263MG	Growth Inhibition Assay			IC50=3.82051 μM	SANGER
KM-H2	Growth Inhibition Assay			IC50=3.82624 μM	SANGER
SK-MEL-3	Growth Inhibition Assay			IC50=3.82841 μM	SANGER
NCI-H1581	Growth Inhibition Assay			IC50=3.84488 μM	SANGER
LS-123	Growth Inhibition Assay			IC50=3.87909 μM	SANGER
CAKI-1	Growth Inhibition Assay			IC50=3.89052 μM	SANGER
MEL-JUSO	Growth Inhibition Assay			IC50=3.89153 μM	SANGER
HCE-4	Growth Inhibition Assay			IC50=3.91663 μM	SANGER
TE-10	Growth Inhibition Assay			IC50=3.9201 μM	SANGER
OVCAR-4	Growth Inhibition Assay			IC50=3.92889 μM	SANGER
ETK-1	Growth Inhibition Assay			IC50=3.94635 μM	SANGER
A2780	Growth Inhibition Assay			IC50=4.05966 μM	SANGER
LU-65	Growth Inhibition Assay			IC50=4.07633 μM	SANGER
BHY	Growth Inhibition Assay			IC50=4.12495 μM	SANGER
COR-L105	Growth Inhibition Assay			IC50=4.13051 μM	SANGER
CAL-12T	Growth Inhibition Assay			IC50=4.13103 μM	SANGER
SCH	Growth Inhibition Assay			IC50=4.15743 μM	SANGER
CW-2	Growth Inhibition Assay			IC50=4.19001 μM	SANGER
HCC1806	Growth Inhibition Assay			IC50=4.20312 μM	SANGER
KP-N-YN	Growth Inhibition Assay			IC50=4.20927 μM	SANGER
T98G	Growth Inhibition Assay			IC50=4.22157 μM	SANGER
CAL-54	Growth Inhibition Assay			IC50=4.22381 μM	SANGER
CAL-33	Growth Inhibition Assay			IC50=4.23064 μM	SANGER
SNU-C2B	Growth Inhibition Assay			IC50=4.24769 μM	SANGER
NUGC-3	Growth Inhibition Assay			IC50=4.25505 μM	SANGER
DOK	Growth Inhibition Assay			IC50=4.26593 μM	SANGER
MMAC-SF	Growth Inhibition Assay			IC50=4.26859 μM	SANGER
KYSE-70	Growth Inhibition Assay			IC50=4.2934 μM	SANGER
A204	Growth Inhibition Assay			IC50=4.35803 μM	SANGER
SCC-25	Growth Inhibition Assay			IC50=4.35819 μM	SANGER
EPLC-272H	Growth Inhibition Assay			IC50=4.3895 μM	SANGER
CAL-120	Growth Inhibition Assay			IC50=4.38992 μM	SANGER
LS-513	Growth Inhibition Assay			IC50=4.42198 μM	SANGER
CAPAN-1	Growth Inhibition Assay			IC50=4.42382 μM	SANGER
ESS-1	Growth Inhibition Assay			IC50=4.42724 μM	SANGER
GMS-10	Growth Inhibition Assay			IC50=4.42819 μM	SANGER
NCI-N87	Growth Inhibition Assay			IC50=4.50868 μM	SANGER
HMV-II	Growth Inhibition Assay			IC50=4.5173 μM	SANGER
COLO-741	Growth Inhibition Assay			IC50=4.55994 μM	SANGER
MKN45	Growth Inhibition Assay			IC50=4.57732 μM	SANGER
OAW-28	Growth Inhibition Assay			IC50=4.58398 μM	SANGER
OCI-AML2	Growth Inhibition Assay			IC50=4.65238 μM	SANGER
MDA-MB-231	Growth Inhibition Assay			IC50=4.70243 μM	SANGER
NCI-H1648	Growth Inhibition Assay			IC50=4.72273 μM	SANGER
NCI-H1792	Growth Inhibition Assay			IC50=4.76107 μM	SANGER
GCIY	Growth Inhibition Assay			IC50=4.77424 μM	SANGER
Hs-578-T	Growth Inhibition Assay			IC50=4.77655 μM	SANGER
SW962	Growth Inhibition Assay			IC50=4.78011 μM	SANGER
NCI-H630	Growth Inhibition Assay			IC50=4.78081 μM	SANGER
786-0	Growth Inhibition Assay			IC50=4.78773 μM	SANGER
FTC-133	Growth Inhibition Assay			IC50=4.79263 μM	SANGER
BT-20	Growth Inhibition Assay			IC50=4.79429 μM	SANGER
Mewo	Growth Inhibition Assay			IC50=4.81747 μM	SANGER
SW780	Growth Inhibition Assay			IC50=4.85766 μM	SANGER
OE33	Growth Inhibition Assay			IC50=4.87713 μM	SANGER
HCC1569	Growth Inhibition Assay			IC50=4.88458 μM	SANGER
TE-6	Growth Inhibition Assay			IC50=4.93977 μM	SANGER
SK-N-FI	Growth Inhibition Assay			IC50=4.94421 μM	SANGER
PANC-03-27	Growth Inhibition Assay			IC50=4.99962 μM	SANGER
MCF7	Growth Inhibition Assay			IC50=5.00738 μM	SANGER
UACC-257	Growth Inhibition Assay			IC50=5.02845 μM	SANGER
SW1088	Growth Inhibition Assay			IC50=5.02944 μM	SANGER
A704	Growth Inhibition Assay			IC50=5.0306 μM	SANGER
A2058	Growth Inhibition Assay			IC50=5.05908 μM	SANGER
Calu-3	Growth Inhibition Assay			IC50=5.06452 μM	SANGER
RERF-LC-MS	Growth Inhibition Assay			IC50=5.06903 μM	SANGER
AU565	Growth Inhibition Assay			IC50=5.09702 μM	SANGER
DMS-79	Growth Inhibition Assay			IC50=5.13883 μM	SANGER
DK-MG	Growth Inhibition Assay			IC50=5.18438 μM	SANGER
HuCCT1	Growth Inhibition Assay			IC50=5.23856 μM	SANGER
HT-144	Growth Inhibition Assay			IC50=5.24987 μM	SANGER
M059J	Growth Inhibition Assay			IC50=5.2576 μM	SANGER
COLO-792	Growth Inhibition Assay			IC50=5.26356 μM	SANGER
SF539	Growth Inhibition Assay			IC50=5.26632 μM	SANGER
SK-UT-1	Growth Inhibition Assay			IC50=5.27751 μM	SANGER
NCI-H1703	Growth Inhibition Assay			IC50=5.35826 μM	SANGER
SW837	Growth Inhibition Assay			IC50=5.37878 μM	SANGER
U251	Growth Inhibition Assay			IC50=5.39096 μM	SANGER
SW1710	Growth Inhibition Assay			IC50=5.41554 μM	SANGER
NCI-H1299	Growth Inhibition Assay			IC50=5.46335 μM	SANGER
RVH-421	Growth Inhibition Assay			IC50=5.49908 μM	SANGER
UM-UC-3	Growth Inhibition Assay			IC50=5.62651 μM	SANGER
MDA-MB-175-VII	Growth Inhibition Assay			IC50=5.64041 μM	SANGER
KYSE-270	Growth Inhibition Assay			IC50=5.66031 μM	SANGER
COLO-668	Growth Inhibition Assay			IC50=5.7132 μM	SANGER
LN-405	Growth Inhibition Assay			IC50=5.73085 μM	SANGER
HT-1376	Growth Inhibition Assay			IC50=5.78052 μM	SANGER
769-P	Growth Inhibition Assay			IC50=5.86718 μM	SANGER
HuP-T3	Growth Inhibition Assay			IC50=5.88677 μM	SANGER
MDA-MB-415	Growth Inhibition Assay			IC50=5.92139 μM	SANGER
MKN7	Growth Inhibition Assay			IC50=5.988 μM	SANGER
KS-1	Growth Inhibition Assay			IC50=5.98836 μM	SANGER
647-V	Growth Inhibition Assay			IC50=5.99148 μM	SANGER
COLO-679	Growth Inhibition Assay			IC50=6.00255 μM	SANGER
AN3-CA	Growth Inhibition Assay			IC50=6.03441 μM	SANGER
C32	Growth Inhibition Assay			IC50=6.13034 μM	SANGER
KM12	Growth Inhibition Assay			IC50=6.24099 μM	SANGER
KINGS-1	Growth Inhibition Assay			IC50=6.26152 μM	SANGER
KYSE-410	Growth Inhibition Assay			IC50=6.30645 μM	SANGER
HPAF-II	Growth Inhibition Assay			IC50=6.3548 μM	SANGER
LAN-6	Growth Inhibition Assay			IC50=6.49631 μM	SANGER
LU-99A	Growth Inhibition Assay			IC50=6.55989 μM	SANGER
SJSA-1	Growth Inhibition Assay			IC50=6.56347 μM	SANGER
MSTO-211H	Growth Inhibition Assay			IC50=6.72233 μM	SANGER
SW900	Growth Inhibition Assay			IC50=6.76221 μM	SANGER
LNCaP-Clone-FGC	Growth Inhibition Assay			IC50=6.80403 μM	SANGER
OMC-1	Growth Inhibition Assay			IC50=6.85402 μM	SANGER
IST-MEL1	Growth Inhibition Assay			IC50=6.89669 μM	SANGER
TE-9	Growth Inhibition Assay			IC50=6.89847 μM	SANGER
NCI-H2030	Growth Inhibition Assay			IC50=6.91226 μM	SANGER
BFTC-909	Growth Inhibition Assay			IC50=7.00641 μM	SANGER
NCI-SNU-5	Growth Inhibition Assay			IC50=7.02159 μM	SANGER
TE-5	Growth Inhibition Assay			IC50=7.02881 μM	SANGER
SK-MES-1	Growth Inhibition Assay			IC50=7.05427 μM	SANGER
SHP-77	Growth Inhibition Assay			IC50=7.13952 μM	SANGER
NCI-H1623	Growth Inhibition Assay			IC50=7.14072 μM	SANGER
TE-11	Growth Inhibition Assay			IC50=7.15184 μM	SANGER
EKVX	Growth Inhibition Assay			IC50=7.19267 μM	SANGER
OVCAR-3	Growth Inhibition Assay			IC50=7.21133 μM	SANGER
C3A	Growth Inhibition Assay			IC50=7.3452 μM	SANGER
CFPAC-1	Growth Inhibition Assay			IC50=7.36222 μM	SANGER
MG-63	Growth Inhibition Assay			IC50=7.41849 μM	SANGER
KYSE-140	Growth Inhibition Assay			IC50=7.44061 μM	SANGER
MPP-89	Growth Inhibition Assay			IC50=7.59729 μM	SANGER
COLO-824	Growth Inhibition Assay			IC50=7.72863 μM	SANGER
SiHa	Growth Inhibition Assay			IC50=7.83707 μM	SANGER
SNU-387	Growth Inhibition Assay			IC50=7.85347 μM	SANGER
A172	Growth Inhibition Assay			IC50=7.86172 μM	SANGER
COLO-680N	Growth Inhibition Assay			IC50=7.9173 μM	SANGER
HCC1395	Growth Inhibition Assay			IC50=8.05452 μM	SANGER
NCI-H28	Growth Inhibition Assay			IC50=8.05963 μM	SANGER
LC-2-ad	Growth Inhibition Assay			IC50=8.21937 μM	SANGER
S-117	Growth Inhibition Assay			IC50=8.25353 μM	SANGER
NCI-H1838	Growth Inhibition Assay			IC50=8.25781 μM	SANGER
PANC-10-05	Growth Inhibition Assay			IC50=8.37047 μM	SANGER
KALS-1	Growth Inhibition Assay			IC50=8.50928 μM	SANGER
LS-1034	Growth Inhibition Assay			IC50=8.57437 μM	SANGER
TGBC1TKB	Growth Inhibition Assay			IC50=8.73535 μM	SANGER
OE19	Growth Inhibition Assay			IC50=8.76262 μM	SANGER
D-502MG	Growth Inhibition Assay			IC50=8.76994 μM	SANGER
JEG-3	Growth Inhibition Assay			IC50=8.78618 μM	SANGER
DBTRG-05MG	Growth Inhibition Assay			IC50=8.87565 μM	SANGER
ME-180	Growth Inhibition Assay			IC50=9.06725 μM	SANGER
NCI-H1573	Growth Inhibition Assay			IC50=9.10532 μM	SANGER
HCC2998	Growth Inhibition Assay			IC50=9.13681 μM	SANGER
ACHN	Growth Inhibition Assay			IC50=9.24975 μM	SANGER
D-392MG	Growth Inhibition Assay			IC50=9.25715 μM	SANGER
no-11	Growth Inhibition Assay			IC50=9.26028 μM	SANGER
KLE	Growth Inhibition Assay			IC50=9.32232 μM	SANGER
Calu-6	Growth Inhibition Assay			IC50=9.37528 μM	SANGER
LB831-BLC	Growth Inhibition Assay			IC50=9.45171 μM	SANGER
SW684	Growth Inhibition Assay			IC50=9.46116 μM	SANGER
SH-4	Growth Inhibition Assay			IC50=9.49364 μM	SANGER
IST-MES1	Growth Inhibition Assay			IC50=9.51644 μM	SANGER
Saos-2	Growth Inhibition Assay			IC50=9.52195 μM	SANGER
NCI-H2087	Growth Inhibition Assay			IC50=9.67352 μM	SANGER
SCC-9	Growth Inhibition Assay			IC50=9.71816 μM	SANGER
MFE-280	Growth Inhibition Assay			IC50=9.72785 μM	SANGER
BEN	Growth Inhibition Assay			IC50=9.82159 μM	SANGER
CP50-MEL-B	Growth Inhibition Assay			IC50=9.92432 μM	SANGER
SK-MEL-28	Growth Inhibition Assay			IC50=10.0193 μM	SANGER
NCI-H2452	Growth Inhibition Assay			IC50=10.16 μM	SANGER
NCI-H1395	Growth Inhibition Assay			IC50=10.178 μM	SANGER
NCI-H2052	Growth Inhibition Assay			IC50=10.1882 μM	SANGER
A375	Growth Inhibition Assay			IC50=10.2452 μM	SANGER
HCC38	Growth Inhibition Assay			IC50=10.322 μM	SANGER
LK-2	Growth Inhibition Assay			IC50=10.4208 μM	SANGER
SF126	Growth Inhibition Assay			IC50=10.4727 μM	SANGER
SK-MEL-1	Growth Inhibition Assay			IC50=10.7838 μM	SANGER
ACN	Growth Inhibition Assay			IC50=10.8679 μM	SANGER
BB30-HNC	Growth Inhibition Assay			IC50=10.8711 μM	SANGER
NCI-H747	Growth Inhibition Assay			IC50=10.8746 μM	SANGER
KYSE-150	Growth Inhibition Assay			IC50=11.0387 μM	SANGER
D-247MG	Growth Inhibition Assay			IC50=11.1009 μM	SANGER
BxPC-3	Growth Inhibition Assay			IC50=11.3747 μM	SANGER
SK-MEL-30	Growth Inhibition Assay			IC50=11.4079 μM	SANGER
CAS-1	Growth Inhibition Assay			IC50=11.4109 μM	SANGER
no-10	Growth Inhibition Assay			IC50=12.1217 μM	SANGER
NCI-H2405	Growth Inhibition Assay			IC50=12.2036 μM	SANGER
KGN	Growth Inhibition Assay			IC50=12.2901 μM	SANGER
BB49-HNC	Growth Inhibition Assay			IC50=12.3956 μM	SANGER
NCI-H1693	Growth Inhibition Assay			IC50=12.5816 μM	SANGER
RO82-W-1	Growth Inhibition Assay			IC50=13.0649 μM	SANGER
CAL-85-1	Growth Inhibition Assay			IC50=13.4399 μM	SANGER
H-EMC-SS	Growth Inhibition Assay			IC50=13.9104 μM	SANGER
SW1783	Growth Inhibition Assay			IC50=14.2391 μM	SANGER
LB771-HNC	Growth Inhibition Assay			IC50=14.419 μM	SANGER
HCC70	Growth Inhibition Assay			IC50=14.4233 μM	SANGER
KNS-81-FD	Growth Inhibition Assay			IC50=14.7045 μM	SANGER
KYSE-520	Growth Inhibition Assay			IC50=14.927 μM	SANGER
TGBC24TKB	Growth Inhibition Assay			IC50=14.9539 μM	SANGER
SNB75	Growth Inhibition Assay			IC50=15.0729 μM	SANGER
SW872	Growth Inhibition Assay			IC50=15.2218 μM	SANGER
U031	Growth Inhibition Assay			IC50=15.8028 μM	SANGER
ChaGo-K-1	Growth Inhibition Assay			IC50=15.8359 μM	SANGER
NCI-H441	Growth Inhibition Assay			IC50=16.0039 μM	SANGER
TE-12	Growth Inhibition Assay			IC50=16.1873 μM	SANGER
NCI-H1755	Growth Inhibition Assay			IC50=16.573 μM	SANGER
KNS-42	Growth Inhibition Assay			IC50=16.6589 μM	SANGER
SK-PN-DW	Growth Inhibition Assay			IC50=17.4201 μM	SANGER
NCI-H226	Growth Inhibition Assay			IC50=17.9345 μM	SANGER
K-562	Growth Inhibition Assay			IC50=18.6317 μM	SANGER
A388	Growth Inhibition Assay			IC50=19.0303 μM	SANGER
ZR-75-30	Growth Inhibition Assay			IC50=19.0968 μM	SANGER
LU-135	Growth Inhibition Assay			IC50=19.2636 μM	SANGER
NCI-H2029	Growth Inhibition Assay			IC50=19.6021 μM	SANGER
HT-1197	Growth Inhibition Assay			IC50=19.9227 μM	SANGER
IGR-1	Growth Inhibition Assay			IC50=20.3117 μM	SANGER
U-87-MG	Growth Inhibition Assay			IC50=20.6413 μM	SANGER
NCI-H1304	Growth Inhibition Assay			IC50=20.7501 μM	SANGER
RCC10RGB	Growth Inhibition Assay			IC50=21.2829 μM	SANGER
NCI-H520	Growth Inhibition Assay			IC50=22.7611 μM	SANGER
SK-LU-1	Growth Inhibition Assay			IC50=23.0718 μM	SANGER
UACC-893	Growth Inhibition Assay			IC50=23.1038 μM	SANGER
NCI-H2347	Growth Inhibition Assay			IC50=23.2674 μM	SANGER
U-118-MG	Growth Inhibition Assay			IC50=23.7217 μM	SANGER
NCI-H596	Growth Inhibition Assay			IC50=23.9055 μM	SANGER
MZ1-PC	Growth Inhibition Assay			IC50=24.6759 μM	SANGER
SW1417	Growth Inhibition Assay			IC50=25.2498 μM	SANGER
NCI-H82	Growth Inhibition Assay			IC50=26.4288 μM	SANGER
COLO-678	Growth Inhibition Assay			IC50=27.4919 μM	SANGER
KURAMOCHI	Growth Inhibition Assay			IC50=28.126 μM	SANGER
NCI-H1650	Growth Inhibition Assay			IC50=30.1924 μM	SANGER
HCC1954	Growth Inhibition Assay			IC50=31.3666 μM	SANGER
GAK	Growth Inhibition Assay			IC50=32.2616 μM	SANGER
YAPC	Growth Inhibition Assay			IC50=33.7648 μM	SANGER
NCI-H2228	Growth Inhibition Assay			IC50=34.3605 μM	SANGER
VMRC-RCZ	Growth Inhibition Assay			IC50=36.3022 μM	SANGER
NMC-G1	Growth Inhibition Assay			IC50=37.0529 μM	SANGER
D-336MG	Growth Inhibition Assay			IC50=41.8442 μM	SANGER
UACC-62	Growth Inhibition Assay			IC50=42.5505 μM	SANGER
C-33-A	Growth Inhibition Assay			IC50=45.3256 μM	SANGER
HCC1937	Growth Inhibition Assay			IC50=47.1958 μM	SANGER
HDLM-2	Growth Inhibition Assay			IC50=47.2287 μM	SANGER
NCI-H727	Growth Inhibition Assay			IC50=47.2451 μM	SANGER
NY	Growth Inhibition Assay			IC50=49.3908 μM	SANGER
NCI-H2291	Growth Inhibition Assay			IC50=49.8301 μM	SANGER
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生物活性

製品説明

Vorinostat (SAHA) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay. Vorinostat abrogates productive HPV-18 DNA amplification.

Targets

HDAC ^[1]
(Cell-free assay)

~10 nM

In Vitro
In vitro	Vorinostat inhibits the activities of HDAC1 and HDAC3 with IC50 of 10 nM and 20 nM, respectively. Vorinostat also results in a marked hyperacetylation of histone H4. ^[1] Vorinostat inhibits the growth of three prostate cancer cell lines LNCaP, PC-3 and TSU-Pr1 at micromolar concentrations (2.5-7.5 μM), and induces dose-dependent cell death in LNCaP cells. ^[2] Vorinostat treatment in MCF-7 cells inhibits cell proliferation at an IC50 of 0.75 μM resulting in the accumulation of cells in the G1 and G2-M phase of the cell cycle. Vorinostat also induces differentiation in the estrogen receptor-negative cell line SKBr-3 and the retinoblastoma-negative cell line MDA-468. ^[3] Vorinostat treatment at 1 μM for 8 hours or more is sufficient to irreversibly induce apoptosis of human multiple myeloma (MM) cells. The gene expression profiles of Vorinostat treated MM cells are not hallmarked by global transcriptional activation, but by coordinated transcriptional changes of specific functional groups of genes such as cytokine-induced proliferative/survival signaling cascades, oncogenes-tumor suppressor genes, regulators of apoptosis, DNA synthesis-repair and cell cycle, and proteasome-ubiquitin function. ^[4]
Kinase Assay	Immunoprecipitation-HDAC assays
Kinase Assay	The lysate of Jurkat cells is incubated for 1 hour on ice and cleared by centrifugation at 12,000 g for 10 minutes at 4 °C. Supernatants are precleared with 30 μL of 50% protein G-Sepharose slurry for 1 hour at 4 °C. Beads are pelleted by centrifugation and supernatants are incubated for 1 hour at 4 °C with 10 μg of IgG fraction from anti-HDAC1 or HDAC3 polyclonal antisera (preincubated 2 hours at room temperature with either the homologous or heterologous immunizing peptide). Both antisera are raised in rabbits against the carboxylterminal peptide of HDAC1 and HDAC3 by using synthetic peptides coupled to keyhole limpet hemocyanin. 30 μL of 50% protein G-Sepharose slurry is added for 1 hour at 4 °C. Immune complexes are pelleted by centrifugation and washed three times with 1 mL of lysis buffer. Beads are resuspended in 200 μL of HDAC buffer (20 mM Tris-HCl, pH 8.0/150 mM NaCl/10% glycerol), and the HDAC assay is performed with an ³H-acetylated peptide corresponding to amino acids 1-24 of histone H4. Released [³H]acetic acid is quantified by scintillation counting. For inhibitions studies, the immunoprecipitated complexes are preincubated with the different concentrations of Vorinostat for 30 minutes at 4 °C.
細胞実験	細胞株	LNCaP, PC-3, and TSU-Pr1
	濃度	Dissolved in DMSO, final concentrations ~7.5 μM
	反応時間	1, 2, 3 and 4 days
	実験の流れ	Cells are exposed to various concentrations of Vorinostat for 1, 2, 3 and 4 days. Cell viability is assessed by trypan blue dye exclusion.
実験結果図	Methods	Biomarkers	結果図	PMID
	Western blot	Ac-Histone H4 / Ac-Histone H3 phospho-CDK1 phospho-Cdc25c / Cdc25c Cyclin B1 c-Myc / c-Raf / Akt / Cyclin D1 / CDK4 p-eIF2α / ATF4 / CHOP p21		21598070
	Immunofluorescence	HDAC1 / CK19 Nrf2 α-SMA Ac-STAT3 / IGF2		29917299
	Growth inhibition assay	Cell apoptosis Cell viability		19440035
	ELISA	IGF2 IL-13 / IL-10 / IL-5 M-CSF MMP-9		27086926

In Vivo
In Vivo	Administration of Vorinostat (~100 mg/kg/day) significantly inhibits the growth of CWR22 human prostate xenografts in nude mice with tumor reductions of 78%, 97% and 97%, at doses of 25 mg/kg/day, 50 mg/kg/day and 100 mg/kg/day, respectively, compared with control. Vorinostat induces the accumulation of acetylated core histones and prostate-specific antigen mRNA expression in CWR22 cells, resulting in higher levels of serum prostate-specific antigen than predicted from tumor volume alone. ^[2] Oral administration of Vorinostat (0.67g/L) crosses the blood-brain barrier, increases histone acetylation in the brain, and dramatically improves the motor impairment in the R6/2 mice model of Huntington's disease. ^[5]
動物実験	動物モデル	Male BALB/c nude (nu/nu) mice implanted with CWR22 tumor cells
	投与量	25, 50, and 100 mg/kg/day
	投与経路	Injection i.p.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
臨床試験 (data from https://clinicaltrials.gov, updated on 2024-05-22)
NCT05700630	Withdrawn	HIV-1-infection\|ART\|Cd4+ Lymphocyte Deficiency\|Lymphoid Tissue; Infection\|Interleukin	Masonic Cancer Center University of Minnesota	July 15 2024	Phase 1
NCT03022565	Withdrawn	Uveal Melanoma	University of Miami\|University of Miami Sylvester Comprehensive Cancer Center	January 2020	Early Phase 1
NCT03167437	Recruiting	Crohn''s Disease	National Institute of Allergy and Infectious Diseases (NIAID)\|National Institutes of Health Clinical Center (CC)	October 30 2017	Phase 1\|Phase 2
NCT03056495	Terminated	Alzheimer Disease	German Center for Neurodegenerative Diseases (DZNE)\|University Hospital Bonn\|University of Göttingen	September 28 2017	Phase 1

参考
[1] Richon VM, et al. Proc Natl Acad Sci U S A, 1998, 95(6), 3003-3007. [2] Butler LM, et al. Cancer Res, 2000, 60(18), 5165-5170. [3] Munster PN, et al. Cancer Res, 2001, 61(23), 8492-8497. [4] Hockly E, et al. Natl Acad Sci U S A, 2003, 100(4), 2041-2046. [5] Mitsiades CS, et al. Proc Natl Acad Sci U S A, 2004, 101(2), 540-545. [6] Pei XY, et al. Clin Cancer Res, 2004, 10(11), 3839-3852. [7] Zhang G, et al. Clin Cancer Res, 2008, 14(17), 5385-5399. [8] Dai Y, et al. Blood, 2008, 112(3), 793-804. + 展開

参考

+ 展開

化学情報

分子量	264.3	化学式	C₁₄H₂₀N₂O₃
CAS No.	149647-78-9	SDF	Download Vorinostat (SAHA) SDFをダウンロードする
Smiles	C1=CC=C(C=C1)NC(=O)CCCCCCC(=O)NO
保管	3年-20°C粉	溶液の保管冷凍と解凍の繰り返しを避けるため小分けにしてください	1年-80°Cin solvent
保管	3年-20°C粉	溶液の保管冷凍と解凍の繰り返しを避けるため小分けにしてください	１ケ月-20°Cin solvent

In vitro
Batch:

DMSO : 52 mg/mL ( (196.74 mM)；吸湿したDMSOは溶解度を減少させます。新しいDMSOをご使用ください。)

Ethanol : 6.5 mg/mL

Water : Insoluble

モル濃度計算器

in vivo
Batch:

Add solvents to the product individually and in order.

投与溶液組成計算機

実験計算

モル濃度計算器

質量	濃度	体積	分子量
=	×	×

希釈計算器分子量計算器

投与溶液組成計算機(クリア溶液)

ステップ１：実験データを入力してください。（実験操作によるロスを考慮し、動物数を1匹分多くして計算・調製することを推奨します）

投与量 mg/kg 動物平均体重 g 投与体積（動物毎）μL 動物数匹

ステップ２：投与溶媒の組成を入力してください。（ロット毎に適した溶解組成が異なる場合があります。詳細については弊社までお問い合わせください）

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

計算結果：

投与溶媒濃度： mg/ml;

DMSOストック溶液調製方法： mg 試薬を μL DMSOに溶解する（濃度 mg/mL, 注：濃度が当該ロットのDMSO溶解度を超える場合はご連絡ください。 )

投与溶媒調製方法：Take μL DMSOストック溶液に μL PEG300，を加え、完全溶解後μL Tween 80，を加えて完全溶解させた後 μL ddH₂O，を加え完全に溶解させます。

投与溶媒調製方法：μL DMSOストック溶液に μL Corn oil，を加え、完全溶解。

注意：１.ストック溶液に沈殿、混濁などがないことをご確認ください；
２.順番通りに溶剤を加えてください。次のステップに進む前に溶液に沈殿、混濁などがないことを確認してから加えてください。ボルテックス、ソニケーション、水浴加熱など物理的な方法で溶解を早めることは可能です。

技術サポート

ストックの作り方、阻害剤の保管方法、細胞実験や動物実験の際に注意すべき点など、製品を取扱う時に問い合わせが多かった質問に対しては取扱説明書でお答えしています。

Handling Instructions

他に質問がある場合は、お気軽にお問い合わせください。

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* 大学・企業名 大学・企業名を記入してください

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よくある質問（FAQ）

質問1:
What’s the recommendation about reconstitution of the compound for in vivo animal study?

回答
We recommend the following vehicle for S1047: 2% DMSO, 40% PEG 300, 5% Propylene glycol, 1% Tween 80 at 5 mg/mL.

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):