- 阻害剤
- 研究分野別
- PI3K/Akt/mTOR
- Epigenetics
- Methylation
- Immunology & Inflammation
- Protein Tyrosine Kinase
- Angiogenesis
- Apoptosis
- Autophagy
- ER stress & UPR
- JAK/STAT
- MAPK
- Cytoskeletal Signaling
- Cell Cycle
- TGF-beta/Smad
- 化合物ライブラリー
- 抗体
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- お問い合わせ
Obatoclax Mesylate (GX15-070)
Obatoclax Mesylate (GX15-070) is an antagonist of Bcl-2 with Ki of 0.22 μM in a cell-free assay, can assist in overcoming MCL-1 mediated resistance to apoptosis.
CAS No. 803712-79-0
文献中Selleckの製品使用例（109）
製品安全説明書
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純度：
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99.85
Obatoclax Mesylate (GX15-070)関連製品
シグナル伝達経路
Bcl-2阻害剤の選択性比較
Cell Data
| Cell Lines | Assay Type | Concentration | Incubation Time | 活性情報 | PMID |
|---|---|---|---|---|---|
| SW1783 | Growth Inhibition Assay | IC50=0.19305 μM | SANGER | ||
| AM-38 | Growth Inhibition Assay | IC50=0.19225 μM | SANGER | ||
| NCI-H441 | Growth Inhibition Assay | IC50=0.19148 μM | SANGER | ||
| MHH-ES-1 | Growth Inhibition Assay | IC50=0.18629 μM | SANGER | ||
| LCLC-103H | Growth Inhibition Assay | IC50=0.18527 μM | SANGER | ||
| Hs-578-T | Growth Inhibition Assay | IC50=0.18292 μM | SANGER | ||
| NCI-H522 | Growth Inhibition Assay | IC50=0.18094 μM | SANGER | ||
| MV-4-11 | Growth Inhibition Assay | IC50=0.17977 μM | SANGER | ||
| 8305C | Growth Inhibition Assay | IC50=0.17971 μM | SANGER | ||
| TYK-nu | Growth Inhibition Assay | IC50=0.17949 μM | SANGER | ||
| TK10 | Growth Inhibition Assay | IC50=0.17702 μM | SANGER | ||
| MKN28 | Growth Inhibition Assay | IC50=0.17653 μM | SANGER | ||
| NCI-H292 | Growth Inhibition Assay | IC50=0.17601 μM | SANGER | ||
| BB65-RCC | Growth Inhibition Assay | IC50=0.17545 μM | SANGER | ||
| BT-474 | Growth Inhibition Assay | IC50=0.17489 μM | SANGER | ||
| DJM-1 | Growth Inhibition Assay | IC50=0.17451 μM | SANGER | ||
| HCC1143 | Growth Inhibition Assay | IC50=0.17396 μM | SANGER | ||
| EB-3 | Growth Inhibition Assay | IC50=0.1731 μM | SANGER | ||
| D-542MG | Growth Inhibition Assay | IC50=0.16986 μM | SANGER | ||
| HLE | Growth Inhibition Assay | IC50=0.16877 μM | SANGER | ||
| ATN-1 | Growth Inhibition Assay | IC50=0.16656 μM | SANGER | ||
| KARPAS-422 | Growth Inhibition Assay | IC50=0.16574 μM | SANGER | ||
| GB-1 | Growth Inhibition Assay | IC50=0.16424 μM | SANGER | ||
| GT3TKB | Growth Inhibition Assay | IC50=0.16283 μM | SANGER | ||
| YKG-1 | Growth Inhibition Assay | IC50=0.16273 μM | SANGER | ||
| DU-4475 | Growth Inhibition Assay | IC50=0.16162 μM | SANGER | ||
| SW872 | Growth Inhibition Assay | IC50=0.16042 μM | SANGER | ||
| SK-MEL-2 | Growth Inhibition Assay | IC50=0.15668 μM | SANGER | ||
| AN3-CA | Growth Inhibition Assay | IC50=0.15639 μM | SANGER | ||
| 639-V | Growth Inhibition Assay | IC50=0.15596 μM | SANGER | ||
| HEL | Growth Inhibition Assay | IC50=0.15447 μM | SANGER | ||
| NCI-H1355 | Growth Inhibition Assay | IC50=0.15293 μM | SANGER | ||
| SJSA-1 | Growth Inhibition Assay | IC50=0.14707 μM | SANGER | ||
| TE-1 | Growth Inhibition Assay | IC50=0.14407 μM | SANGER | ||
| ES6 | Growth Inhibition Assay | IC50=0.1436 μM | SANGER | ||
| NCI-H747 | Growth Inhibition Assay | IC50=0.143 μM | SANGER | ||
| LS-411N | Growth Inhibition Assay | IC50=0.14295 μM | SANGER | ||
| RD | Growth Inhibition Assay | IC50=0.13997 μM | SANGER | ||
| MFE-296 | Growth Inhibition Assay | IC50=0.13864 μM | SANGER | ||
| SK-UT-1 | Growth Inhibition Assay | IC50=0.13628 μM | SANGER | ||
| SK-LU-1 | Growth Inhibition Assay | IC50=0.13449 μM | SANGER | ||
| RPMI-8866 | Growth Inhibition Assay | IC50=0.13261 μM | SANGER | ||
| ACHN | Growth Inhibition Assay | IC50=0.13247 μM | SANGER | ||
| QIMR-WIL | Growth Inhibition Assay | IC50=0.13223 μM | SANGER | ||
| COLO-792 | Growth Inhibition Assay | IC50=0.13165 μM | SANGER | ||
| NCI-H2087 | Growth Inhibition Assay | IC50=0.13027 μM | SANGER | ||
| EW-18 | Growth Inhibition Assay | IC50=0.13026 μM | SANGER | ||
| Ramos-2G6-4C10 | Growth Inhibition Assay | IC50=0.12916 μM | SANGER | ||
| SNU-423 | Growth Inhibition Assay | IC50=0.12914 μM | SANGER | ||
| SK-MES-1 | Growth Inhibition Assay | IC50=0.12913 μM | SANGER | ||
| NCI-H520 | Growth Inhibition Assay | IC50=0.12867 μM | SANGER | ||
| BE-13 | Growth Inhibition Assay | IC50=0.12866 μM | SANGER | ||
| HT-1376 | Growth Inhibition Assay | IC50=0.12668 μM | SANGER | ||
| HCE-T | Growth Inhibition Assay | IC50=0.12531 μM | SANGER | ||
| HCC1806 | Growth Inhibition Assay | IC50=0.12383 μM | SANGER | ||
| EFM-19 | Growth Inhibition Assay | IC50=0.12374 μM | SANGER | ||
| NCI-SNU-1 | Growth Inhibition Assay | IC50=0.12148 μM | SANGER | ||
| NY | Growth Inhibition Assay | IC50=0.11817 μM | SANGER | ||
| J-RT3-T3-5 | Growth Inhibition Assay | IC50=0.1175 μM | SANGER | ||
| NCI-H810 | Growth Inhibition Assay | IC50=0.11664 μM | SANGER | ||
| ES8 | Growth Inhibition Assay | IC50=0.11633 μM | SANGER | ||
| SF539 | Growth Inhibition Assay | IC50=0.11616 μM | SANGER | ||
| PANC-10-05 | Growth Inhibition Assay | IC50=0.11491 μM | SANGER | ||
| EoL-1-cell | Growth Inhibition Assay | IC50=0.11467 μM | SANGER | ||
| MC116 | Growth Inhibition Assay | IC50=0.11337 μM | SANGER | ||
| NCI-H1648 | Growth Inhibition Assay | IC50=0.11286 μM | SANGER | ||
| Ca9-22 | Growth Inhibition Assay | IC50=0.11128 μM | SANGER | ||
| ARH-77 | Growth Inhibition Assay | IC50=0.11 μM | SANGER | ||
| J82 | Growth Inhibition Assay | IC50=0.10884 μM | SANGER | ||
| MZ1-PC | Growth Inhibition Assay | IC50=0.1083 μM | SANGER | ||
| A2058 | Growth Inhibition Assay | IC50=0.10655 μM | SANGER | ||
| NTERA-S-cl-D1 | Growth Inhibition Assay | IC50=0.10448 μM | SANGER | ||
| HTC-C3 | Growth Inhibition Assay | IC50=0.10432 μM | SANGER | ||
| 647-V | Growth Inhibition Assay | IC50=0.10408 μM | SANGER | ||
| HUTU-80 | Growth Inhibition Assay | IC50=0.10365 μM | SANGER | ||
| ES4 | Growth Inhibition Assay | IC50=0.10264 μM | SANGER | ||
| LB771-HNC | Growth Inhibition Assay | IC50=0.10255 μM | SANGER | ||
| NCI-H460 | Growth Inhibition Assay | IC50=0.1009 μM | SANGER | ||
| MN-60 | Growth Inhibition Assay | IC50=0.09897 μM | SANGER | ||
| TE-8 | Growth Inhibition Assay | IC50=0.09885 μM | SANGER | ||
| KYSE-410 | Growth Inhibition Assay | IC50=0.09797 μM | SANGER | ||
| PANC-03-27 | Growth Inhibition Assay | IC50=0.09671 μM | SANGER | ||
| TE-10 | Growth Inhibition Assay | IC50=0.09584 μM | SANGER | ||
| IST-SL2 | Growth Inhibition Assay | IC50=0.09468 μM | SANGER | ||
| U-698-M | Growth Inhibition Assay | IC50=0.09409 μM | SANGER | ||
| NCI-H2122 | Growth Inhibition Assay | IC50=0.09378 μM | SANGER | ||
| HO-1-N-1 | Growth Inhibition Assay | IC50=0.09249 μM | SANGER | ||
| A704 | Growth Inhibition Assay | IC50=0.0915 μM | SANGER | ||
| KMOE-2 | Growth Inhibition Assay | IC50=0.09039 μM | SANGER | ||
| Calu-6 | Growth Inhibition Assay | IC50=0.09029 μM | SANGER | ||
| RPMI-6666 | Growth Inhibition Assay | IC50=0.08967 μM | SANGER | ||
| A4-Fuk | Growth Inhibition Assay | IC50=0.08947 μM | SANGER | ||
| HCT-116 | Growth Inhibition Assay | IC50=0.08802 μM | SANGER | ||
| A431 | Growth Inhibition Assay | IC50=0.08801 μM | SANGER | ||
| CP50-MEL-B | Growth Inhibition Assay | IC50=0.08793 μM | SANGER | ||
| PA-1 | Growth Inhibition Assay | IC50=0.08769 μM | SANGER | ||
| LoVo | Growth Inhibition Assay | IC50=0.0872 μM | SANGER | ||
| LS-123 | Growth Inhibition Assay | IC50=0.08719 μM | SANGER | ||
| A3-KAW | Growth Inhibition Assay | IC50=0.08566 μM | SANGER | ||
| A427 | Growth Inhibition Assay | IC50=0.08512 μM | SANGER | ||
| KURAMOCHI | Growth Inhibition Assay | IC50=0.08509 μM | SANGER | ||
| RS4-11 | Growth Inhibition Assay | IC50=0.08497 μM | SANGER | ||
| 5637 | Growth Inhibition Assay | IC50=0.08367 μM | SANGER | ||
| DEL | Growth Inhibition Assay | IC50=0.08347 μM | SANGER | ||
| HuCCT1 | Growth Inhibition Assay | IC50=0.08333 μM | SANGER | ||
| CESS | Growth Inhibition Assay | IC50=0.08269 μM | SANGER | ||
| HOP-62 | Growth Inhibition Assay | IC50=0.08245 μM | SANGER | ||
| CHP-212 | Growth Inhibition Assay | IC50=0.08095 μM | SANGER | ||
| NCI-H727 | Growth Inhibition Assay | IC50=0.08053 μM | SANGER | ||
| BFTC-905 | Growth Inhibition Assay | IC50=0.07909 μM | SANGER | ||
| NCI-H358 | Growth Inhibition Assay | IC50=0.07879 μM | SANGER | ||
| 8-MG-BA | Growth Inhibition Assay | IC50=0.07801 μM | SANGER | ||
| MMAC-SF | Growth Inhibition Assay | IC50=0.07668 μM | SANGER | ||
| CTB-1 | Growth Inhibition Assay | IC50=0.07588 μM | SANGER | ||
| WSU-NHL | Growth Inhibition Assay | IC50=0.07554 μM | SANGER | ||
| MLMA | Growth Inhibition Assay | IC50=0.07534 μM | SANGER | ||
| CTV-1 | Growth Inhibition Assay | IC50=0.07517 μM | SANGER | ||
| BxPC-3 | Growth Inhibition Assay | IC50=0.07458 μM | SANGER | ||
| P12-ICHIKAWA | Growth Inhibition Assay | IC50=0.07349 μM | SANGER | ||
| YT | Growth Inhibition Assay | IC50=0.07345 μM | SANGER | ||
| ESS-1 | Growth Inhibition Assay | IC50=0.07246 μM | SANGER | ||
| SW626 | Growth Inhibition Assay | IC50=0.07204 μM | SANGER | ||
| Daudi | Growth Inhibition Assay | IC50=0.07081 μM | SANGER | ||
| KYSE-70 | Growth Inhibition Assay | IC50=0.06945 μM | SANGER | ||
| NCI-H226 | Growth Inhibition Assay | IC50=0.06632 μM | SANGER | ||
| SW962 | Growth Inhibition Assay | IC50=0.06569 μM | SANGER | ||
| CA46 | Growth Inhibition Assay | IC50=0.06537 μM | SANGER | ||
| CAL-27 | Growth Inhibition Assay | IC50=0.06464 μM | SANGER | ||
| NB13 | Growth Inhibition Assay | IC50=0.06421 μM | SANGER | ||
| NOS-1 | Growth Inhibition Assay | IC50=0.06411 μM | SANGER | ||
| BL-70 | Growth Inhibition Assay | IC50=0.06302 μM | SANGER | ||
| BL-41 | Growth Inhibition Assay | IC50=0.06219 μM | SANGER | ||
| LOXIMVI | Growth Inhibition Assay | IC50=0.06188 μM | SANGER | ||
| KYSE-180 | Growth Inhibition Assay | IC50=0.06142 μM | SANGER | ||
| COR-L23 | Growth Inhibition Assay | IC50=0.06134 μM | SANGER | ||
| NCI-H1299 | Growth Inhibition Assay | IC50=0.0613 μM | SANGER | ||
| IA-LM | Growth Inhibition Assay | IC50=0.06053 μM | SANGER | ||
| BC-1 | Growth Inhibition Assay | IC50=0.06022 μM | SANGER | ||
| BCPAP | Growth Inhibition Assay | IC50=0.05892 μM | SANGER | ||
| GAMG | Growth Inhibition Assay | IC50=0.058 μM | SANGER | ||
| OCI-AML2 | Growth Inhibition Assay | IC50=0.05777 μM | SANGER | ||
| SF268 | Growth Inhibition Assay | IC50=0.05756 μM | SANGER | ||
| SK-PN-DW | Growth Inhibition Assay | IC50=0.05729 μM | SANGER | ||
| COLO-205 | Growth Inhibition Assay | IC50=0.05716 μM | SANGER | ||
| A388 | Growth Inhibition Assay | IC50=0.05695 μM | SANGER | ||
| ETK-1 | Growth Inhibition Assay | IC50=0.05672 μM | SANGER | ||
| Daoy | Growth Inhibition Assay | IC50=0.05616 μM | SANGER | ||
| LCLC-97TM1 | Growth Inhibition Assay | IC50=0.05594 μM | SANGER | ||
| NEC8 | Growth Inhibition Assay | IC50=0.0559 μM | SANGER | ||
| 697 | Growth Inhibition Assay | IC50=0.05323 μM | SANGER | ||
| COLO-320-HSR | Growth Inhibition Assay | IC50=0.05289 μM | SANGER | ||
| PC-14 | Growth Inhibition Assay | IC50=0.05252 μM | SANGER | ||
| HMV-II | Growth Inhibition Assay | IC50=0.05239 μM | SANGER | ||
| NCI-H2342 | Growth Inhibition Assay | IC50=0.05117 μM | SANGER | ||
| LK-2 | Growth Inhibition Assay | IC50=0.05063 μM | SANGER | ||
| COLO-680N | Growth Inhibition Assay | IC50=0.05047 μM | SANGER | ||
| PF-382 | Growth Inhibition Assay | IC50=0.04939 μM | SANGER | ||
| MRK-nu-1 | Growth Inhibition Assay | IC50=0.04936 μM | SANGER | ||
| SCC-15 | Growth Inhibition Assay | IC50=0.04902 μM | SANGER | ||
| ES1 | Growth Inhibition Assay | IC50=0.04885 μM | SANGER | ||
| CHL-1 | Growth Inhibition Assay | IC50=0.04857 μM | SANGER | ||
| NCI-H1770 | Growth Inhibition Assay | IC50=0.04697 μM | SANGER | ||
| L-363 | Growth Inhibition Assay | IC50=0.04679 μM | SANGER | ||
| REH | Growth Inhibition Assay | IC50=0.04635 μM | SANGER | ||
| SCC-25 | Growth Inhibition Assay | IC50=0.04494 μM | SANGER | ||
| HT-29 | Growth Inhibition Assay | IC50=0.0449 μM | SANGER | ||
| EW-13 | Growth Inhibition Assay | IC50=0.04406 μM | SANGER | ||
| LB373-MEL-D | Growth Inhibition Assay | IC50=0.04232 μM | SANGER | ||
| HuP-T4 | Growth Inhibition Assay | IC50=0.04118 μM | SANGER | ||
| SW1710 | Growth Inhibition Assay | IC50=0.04018 μM | SANGER | ||
| KYSE-150 | Growth Inhibition Assay | IC50=0.04011 μM | SANGER | ||
| CAL-51 | Growth Inhibition Assay | IC50=0.04005 μM | SANGER | ||
| EW-16 | Growth Inhibition Assay | IC50=0.03909 μM | SANGER | ||
| NCI-H64 | Growth Inhibition Assay | IC50=0.03842 μM | SANGER | ||
| SW756 | Growth Inhibition Assay | IC50=0.03821 μM | SANGER | ||
| HEC-1 | Growth Inhibition Assay | IC50=0.0368 μM | SANGER | ||
| HOS | Growth Inhibition Assay | IC50=0.03473 μM | SANGER | ||
| DoTc2-4510 | Growth Inhibition Assay | IC50=0.03393 μM | SANGER | ||
| IMR-5 | Growth Inhibition Assay | IC50=0.03244 μM | SANGER | ||
| OVCAR-8 | Growth Inhibition Assay | IC50=0.03107 μM | SANGER | ||
| G-401 | Growth Inhibition Assay | IC50=0.03093 μM | SANGER | ||
| A101D | Growth Inhibition Assay | IC50=0.03055 μM | SANGER | ||
| NUGC-3 | Growth Inhibition Assay | IC50=0.03048 μM | SANGER | ||
| 8505C | Growth Inhibition Assay | IC50=0.0304 μM | SANGER | ||
| CMK | Growth Inhibition Assay | IC50=0.03023 μM | SANGER | ||
| KYSE-270 | Growth Inhibition Assay | IC50=0.02976 μM | SANGER | ||
| MZ2-MEL | Growth Inhibition Assay | IC50=0.02959 μM | SANGER | ||
| SUP-T1 | Growth Inhibition Assay | IC50=0.02949 μM | SANGER | ||
| S-117 | Growth Inhibition Assay | IC50=0.02906 μM | SANGER | ||
| DMS-273 | Growth Inhibition Assay | IC50=0.02847 μM | SANGER | ||
| CAL-62 | Growth Inhibition Assay | IC50=0.02602 μM | SANGER | ||
| MEL-JUSO | Growth Inhibition Assay | IC50=0.02473 μM | SANGER | ||
| HSC-2 | Growth Inhibition Assay | IC50=0.02466 μM | SANGER | ||
| MC-CAR | Growth Inhibition Assay | IC50=0.02356 μM | SANGER | ||
| MEL-HO | Growth Inhibition Assay | IC50=0.02348 μM | SANGER | ||
| RPMI-2650 | Growth Inhibition Assay | IC50=0.02296 μM | SANGER | ||
| A2780 | Growth Inhibition Assay | IC50=0.02079 μM | SANGER | ||
| ONS-76 | Growth Inhibition Assay | IC50=0.02036 μM | SANGER | ||
| THP-1 | Growth Inhibition Assay | IC50=0.01998 μM | SANGER | ||
| RPMI-8402 | Growth Inhibition Assay | IC50=0.01858 μM | SANGER | ||
| CAL-85-1 | Growth Inhibition Assay | IC50=0.01832 μM | SANGER | ||
| HCC1569 | Growth Inhibition Assay | IC50=0.01797 μM | SANGER | ||
| TGW | Growth Inhibition Assay | IC50=0.01739 μM | SANGER | ||
| RVH-421 | Growth Inhibition Assay | IC50=0.01674 μM | SANGER | ||
| LC-2-ad | Growth Inhibition Assay | IC50=0.01581 μM | SANGER | ||
| NB69 | Growth Inhibition Assay | IC50=0.01565 μM | SANGER | ||
| DOHH-2 | Growth Inhibition Assay | IC50=0.01412 μM | SANGER | ||
| HSC-3 | Growth Inhibition Assay | IC50=0.01355 μM | SANGER | ||
| CAL-12T | Growth Inhibition Assay | IC50=0.01346 μM | SANGER | ||
| SNG-M | Growth Inhibition Assay | IC50=0.01317 μM | SANGER | ||
| SR | Growth Inhibition Assay | IC50=0.01235 μM | SANGER | ||
| SW1417 | Growth Inhibition Assay | IC50=0.01225 μM | SANGER | ||
| ACN | Growth Inhibition Assay | IC50=0.01131 μM | SANGER | ||
| RKO | Growth Inhibition Assay | IC50=0.01044 μM | SANGER | ||
| NKM-1 | Growth Inhibition Assay | IC50=0.00972 μM | SANGER | ||
| IPC-298 | Growth Inhibition Assay | IC50=0.00927 μM | SANGER | ||
| BB30-HNC | Growth Inhibition Assay | IC50=0.00858 μM | SANGER | ||
| GAK | Growth Inhibition Assay | IC50=0.00848 μM | SANGER | ||
| ES7 | Growth Inhibition Assay | IC50=0.00846 μM | SANGER | ||
| ST486 | Growth Inhibition Assay | IC50=0.00825 μM | SANGER | ||
| IST-MEL1 | Growth Inhibition Assay | IC50=0.00818 μM | SANGER | ||
| SIG-M5 | Growth Inhibition Assay | IC50=0.0071 μM | SANGER | ||
| HN | Growth Inhibition Assay | IC50=0.00679 μM | SANGER | ||
| 769-P | Growth Inhibition Assay | IC50=0.00678 μM | SANGER | ||
| EW-1 | Growth Inhibition Assay | IC50=0.00651 μM | SANGER | ||
| IGR-1 | Growth Inhibition Assay | IC50=0.00601 μM | SANGER | ||
| IGROV-1 | Growth Inhibition Assay | IC50=0.006 μM | SANGER | ||
| HGC-27 | Growth Inhibition Assay | IC50=0.00524 μM | SANGER | ||
| SW620 | Growth Inhibition Assay | IC50=0.00511 μM | SANGER | ||
| COLO-679 | Growth Inhibition Assay | IC50=0.00498 μM | SANGER | ||
| PSN1 | Growth Inhibition Assay | IC50=0.00467 μM | SANGER | ||
| KYSE-140 | Growth Inhibition Assay | IC50=0.00435 μM | SANGER | ||
| HT-144 | Growth Inhibition Assay | IC50=0.0043 μM | SANGER | ||
| SH-4 | Growth Inhibition Assay | IC50=0.00417 μM | SANGER | ||
| MZ7-mel | Growth Inhibition Assay | IC50=0.00399 μM | SANGER | ||
| A375 | Growth Inhibition Assay | IC50=0.0035 μM | SANGER | ||
| HCC2998 | Growth Inhibition Assay | IC50=0.00335 μM | SANGER | ||
| HAL-01 | Growth Inhibition Assay | IC50=0.00297 μM | SANGER | ||
| SK-MEL-3 | Growth Inhibition Assay | IC50=0.00264 μM | SANGER | ||
| KYSE-510 | Growth Inhibition Assay | IC50=0.00233 μM | SANGER | ||
| EW-7 | Growth Inhibition Assay | IC50=0.00175 μM | SANGER | ||
| LOUCY | Growth Inhibition Assay | IC50=0.00175 μM | SANGER | ||
| MCF7 | Growth Inhibition Assay | IC50=0.00159 μM | SANGER | ||
| MHH-PREB-1 | Growth Inhibition Assay | IC50=0.0014 μM | SANGER | ||
| KE-37 | Growth Inhibition Assay | IC50=0.00128 μM | SANGER | ||
| G-361 | Growth Inhibition Assay | IC50=0.00124 μM | SANGER | ||
| EB2 | Growth Inhibition Assay | IC50=0.00118 μM | SANGER | ||
| BHT-101 | Growth Inhibition Assay | IC50=0.00106 μM | SANGER | ||
| C-33-A | Growth Inhibition Assay | IC50=0.000848 μM | SANGER | ||
| 786-0 | Growth Inhibition Assay | IC50=0.000776 μM | SANGER | ||
| GR-ST | Growth Inhibition Assay | IC50=0.000648 μM | SANGER | ||
| BHY | Growth Inhibition Assay | IC50=0.000601 μM | SANGER | ||
| KYSE-450 | Growth Inhibition Assay | IC50=0.000469 μM | SANGER | ||
| NALM-6 | Growth Inhibition Assay | IC50=0.000356 μM | SANGER | ||
| SK-MEL-30 | Growth Inhibition Assay | IC50=0.000355 μM | SANGER | ||
| KARPAS-45 | Growth Inhibition Assay | IC50=0.0000317 μM | SANGER | ||
| SK-HEP-1 | Growth Inhibition Assay | IC50=0.19637 μM | SANGER | ||
| OAW-28 | Growth Inhibition Assay | IC50=0.20178 μM | SANGER | ||
| TE-15 | Growth Inhibition Assay | IC50=0.20252 μM | SANGER | ||
| HCE-4 | Growth Inhibition Assay | IC50=0.20284 μM | SANGER | ||
| JiyoyeP-2003 | Growth Inhibition Assay | IC50=0.20336 μM | SANGER | ||
| OVCAR-4 | Growth Inhibition Assay | IC50=0.20628 μM | SANGER | ||
| SNU-449 | Growth Inhibition Assay | IC50=0.20797 μM | SANGER | ||
| SBC-5 | Growth Inhibition Assay | IC50=0.21215 μM | SANGER | ||
| T84 | Growth Inhibition Assay | IC50=0.21248 μM | SANGER | ||
| LP-1 | Growth Inhibition Assay | IC50=0.21302 μM | SANGER | ||
| MG-63 | Growth Inhibition Assay | IC50=0.21382 μM | SANGER | ||
| OAW-42 | Growth Inhibition Assay | IC50=0.21478 μM | SANGER | ||
| L-540 | Growth Inhibition Assay | IC50=0.21598 μM | SANGER | ||
| RH-1 | Growth Inhibition Assay | IC50=0.22242 μM | SANGER | ||
| HCT-15 | Growth Inhibition Assay | IC50=0.22484 μM | SANGER | ||
| OCUB-M | Growth Inhibition Assay | IC50=0.22488 μM | SANGER | ||
| GP5d | Growth Inhibition Assay | IC50=0.22528 μM | SANGER | ||
| NCI-H2030 | Growth Inhibition Assay | IC50=0.22734 μM | SANGER | ||
| ML-2 | Growth Inhibition Assay | IC50=0.22889 μM | SANGER | ||
| CAL-39 | Growth Inhibition Assay | IC50=0.22936 μM | SANGER | ||
| MIA-PaCa-2 | Growth Inhibition Assay | IC50=0.23287 μM | SANGER | ||
| TE-9 | Growth Inhibition Assay | IC50=0.2332 μM | SANGER | ||
| LB2518-MEL | Growth Inhibition Assay | IC50=0.23372 μM | SANGER | ||
| DB | Growth Inhibition Assay | IC50=0.23438 μM | SANGER | ||
| NCI-H596 | Growth Inhibition Assay | IC50=0.23571 μM | SANGER | ||
| SW1990 | Growth Inhibition Assay | IC50=0.23946 μM | SANGER | ||
| P30-OHK | Growth Inhibition Assay | IC50=0.2405 μM | SANGER | ||
| ALL-PO | Growth Inhibition Assay | IC50=0.24169 μM | SANGER | ||
| Saos-2 | Growth Inhibition Assay | IC50=0.24571 μM | SANGER | ||
| MFH-ino | Growth Inhibition Assay | IC50=0.24692 μM | SANGER | ||
| OE33 | Growth Inhibition Assay | IC50=0.2511 μM | SANGER | ||
| Calu-3 | Growth Inhibition Assay | IC50=0.25297 μM | SANGER | ||
| HT | Growth Inhibition Assay | IC50=0.25621 μM | SANGER | ||
| LXF-289 | Growth Inhibition Assay | IC50=0.25984 μM | SANGER | ||
| KGN | Growth Inhibition Assay | IC50=0.26089 μM | SANGER | ||
| NCI-H1417 | Growth Inhibition Assay | IC50=0.26524 μM | SANGER | ||
| SF126 | Growth Inhibition Assay | IC50=0.27302 μM | SANGER | ||
| SAS | Growth Inhibition Assay | IC50=0.27308 μM | SANGER | ||
| 22RV1 | Growth Inhibition Assay | IC50=0.27378 μM | SANGER | ||
| GI-1 | Growth Inhibition Assay | IC50=0.27487 μM | SANGER | ||
| ES3 | Growth Inhibition Assay | IC50=0.27763 μM | SANGER | ||
| NB1 | Growth Inhibition Assay | IC50=0.27876 μM | SANGER | ||
| NCI-H650 | Growth Inhibition Assay | IC50=0.28302 μM | SANGER | ||
| IST-MES1 | Growth Inhibition Assay | IC50=0.28554 μM | SANGER | ||
| UM-UC-3 | Growth Inhibition Assay | IC50=0.2914 μM | SANGER | ||
| CAL-120 | Growth Inhibition Assay | IC50=0.29631 μM | SANGER | ||
| UACC-62 | Growth Inhibition Assay | IC50=0.30241 μM | SANGER | ||
| TE-11 | Growth Inhibition Assay | IC50=0.30249 μM | SANGER | ||
| MKN1 | Growth Inhibition Assay | IC50=0.3036 μM | SANGER | ||
| KS-1 | Growth Inhibition Assay | IC50=0.30526 μM | SANGER | ||
| GCIY | Growth Inhibition Assay | IC50=0.31002 μM | SANGER | ||
| OVCAR-5 | Growth Inhibition Assay | IC50=0.31106 μM | SANGER | ||
| U-266 | Growth Inhibition Assay | IC50=0.31147 μM | SANGER | ||
| Calu-1 | Growth Inhibition Assay | IC50=0.31289 μM | SANGER | ||
| SK-LMS-1 | Growth Inhibition Assay | IC50=0.31429 μM | SANGER | ||
| COLO-741 | Growth Inhibition Assay | IC50=0.31614 μM | SANGER | ||
| RPMI-8226 | Growth Inhibition Assay | IC50=0.31641 μM | SANGER | ||
| KM12 | Growth Inhibition Assay | IC50=0.3183 μM | SANGER | ||
| NMC-G1 | Growth Inhibition Assay | IC50=0.3186 μM | SANGER | ||
| SJRH30 | Growth Inhibition Assay | IC50=0.32052 μM | SANGER | ||
| COR-L105 | Growth Inhibition Assay | IC50=0.32218 μM | SANGER | ||
| IM-9 | Growth Inhibition Assay | IC50=0.33021 μM | SANGER | ||
| TE-12 | Growth Inhibition Assay | IC50=0.33317 μM | SANGER | ||
| KG-1 | Growth Inhibition Assay | IC50=0.33432 μM | SANGER | ||
| U251 | Growth Inhibition Assay | IC50=0.33456 μM | SANGER | ||
| EFO-27 | Growth Inhibition Assay | IC50=0.33951 μM | SANGER | ||
| EW-24 | Growth Inhibition Assay | IC50=0.33984 μM | SANGER | ||
| SF295 | Growth Inhibition Assay | IC50=0.33999 μM | SANGER | ||
| MC-IXC | Growth Inhibition Assay | IC50=0.345 μM | SANGER | ||
| NCI-H2405 | Growth Inhibition Assay | IC50=0.34732 μM | SANGER | ||
| NCI-H2009 | Growth Inhibition Assay | IC50=0.34739 μM | SANGER | ||
| LB1047-RCC | Growth Inhibition Assay | IC50=0.35815 μM | SANGER | ||
| KNS-81-FD | Growth Inhibition Assay | IC50=0.36667 μM | SANGER | ||
| HOP-92 | Growth Inhibition Assay | IC50=0.3683 μM | SANGER | ||
| L-428 | Growth Inhibition Assay | IC50=0.37016 μM | SANGER | ||
| C3A | Growth Inhibition Assay | IC50=0.37379 μM | SANGER | ||
| NCI-H1792 | Growth Inhibition Assay | IC50=0.37655 μM | SANGER | ||
| HuH-7 | Growth Inhibition Assay | IC50=0.3791 μM | SANGER | ||
| AGS | Growth Inhibition Assay | IC50=0.38638 μM | SANGER | ||
| HT-1197 | Growth Inhibition Assay | IC50=0.3946 μM | SANGER | ||
| CGTH-W-1 | Growth Inhibition Assay | IC50=0.39913 μM | SANGER | ||
| KNS-42 | Growth Inhibition Assay | IC50=0.40045 μM | SANGER | ||
| HuO-3N1 | Growth Inhibition Assay | IC50=0.40055 μM | SANGER | ||
| VMRC-RCZ | Growth Inhibition Assay | IC50=0.40303 μM | SANGER | ||
| SW954 | Growth Inhibition Assay | IC50=0.40335 μM | SANGER | ||
| MES-SA | Growth Inhibition Assay | IC50=0.40505 μM | SANGER | ||
| Ca-Ski | Growth Inhibition Assay | IC50=0.40524 μM | SANGER | ||
| SW13 | Growth Inhibition Assay | IC50=0.40626 μM | SANGER | ||
| NCI-H1437 | Growth Inhibition Assay | IC50=0.40805 μM | SANGER | ||
| U-118-MG | Growth Inhibition Assay | IC50=0.40904 μM | SANGER | ||
| NCI-H1734 | Growth Inhibition Assay | IC50=0.42013 μM | SANGER | ||
| HDLM-2 | Growth Inhibition Assay | IC50=0.42033 μM | SANGER | ||
| AU565 | Growth Inhibition Assay | IC50=0.42468 μM | SANGER | ||
| FADU | Growth Inhibition Assay | IC50=0.42649 μM | SANGER | ||
| OS-RC-2 | Growth Inhibition Assay | IC50=0.43083 μM | SANGER | ||
| CAMA-1 | Growth Inhibition Assay | IC50=0.43626 μM | SANGER | ||
| MONO-MAC-6 | Growth Inhibition Assay | IC50=0.43849 μM | SANGER | ||
| LB831-BLC | Growth Inhibition Assay | IC50=0.44371 μM | SANGER | ||
| SW982 | Growth Inhibition Assay | IC50=0.44528 μM | SANGER | ||
| SCC-3 | Growth Inhibition Assay | IC50=0.44579 μM | SANGER | ||
| C32 | Growth Inhibition Assay | IC50=0.45229 μM | SANGER | ||
| BFTC-909 | Growth Inhibition Assay | IC50=0.45299 μM | SANGER | ||
| MEG-01 | Growth Inhibition Assay | IC50=0.45373 μM | SANGER | ||
| M14 | Growth Inhibition Assay | IC50=0.45979 μM | SANGER | ||
| MPP-89 | Growth Inhibition Assay | IC50=0.46256 μM | SANGER | ||
| HCC1937 | Growth Inhibition Assay | IC50=0.46384 μM | SANGER | ||
| SW837 | Growth Inhibition Assay | IC50=0.46722 μM | SANGER | ||
| DU-145 | Growth Inhibition Assay | IC50=0.46729 μM | SANGER | ||
| LB996-RCC | Growth Inhibition Assay | IC50=0.47054 μM | SANGER | ||
| C8166 | Growth Inhibition Assay | IC50=0.474 μM | SANGER | ||
| MOLT-4 | Growth Inhibition Assay | IC50=0.47734 μM | SANGER | ||
| DMS-53 | Growth Inhibition Assay | IC50=0.47809 μM | SANGER | ||
| TE-5 | Growth Inhibition Assay | IC50=0.48305 μM | SANGER | ||
| KYSE-520 | Growth Inhibition Assay | IC50=0.48343 μM | SANGER | ||
| Detroit562 | Growth Inhibition Assay | IC50=0.4886 μM | SANGER | ||
| SIMA | Growth Inhibition Assay | IC50=0.49417 μM | SANGER | ||
| NCI-H1651 | Growth Inhibition Assay | IC50=0.4967 μM | SANGER | ||
| HCC1599 | Growth Inhibition Assay | IC50=0.49955 μM | SANGER | ||
| ABC-1 | Growth Inhibition Assay | IC50=0.50496 μM | SANGER | ||
| CAL-33 | Growth Inhibition Assay | IC50=0.50844 μM | SANGER | ||
| OPM-2 | Growth Inhibition Assay | IC50=0.50937 μM | SANGER | ||
| RPMI-7951 | Growth Inhibition Assay | IC50=0.50957 μM | SANGER | ||
| HT-1080 | Growth Inhibition Assay | IC50=0.51119 μM | SANGER | ||
| LC4-1 | Growth Inhibition Assay | IC50=0.51403 μM | SANGER | ||
| OVCAR-3 | Growth Inhibition Assay | IC50=0.5157 μM | SANGER | ||
| CAPAN-1 | Growth Inhibition Assay | IC50=0.52288 μM | SANGER | ||
| SK-OV-3 | Growth Inhibition Assay | IC50=0.52434 μM | SANGER | ||
| HuP-T3 | Growth Inhibition Assay | IC50=0.52827 μM | SANGER | ||
| NCI-H838 | Growth Inhibition Assay | IC50=0.52849 μM | SANGER | ||
| K5 | Growth Inhibition Assay | IC50=0.53201 μM | SANGER | ||
| CAL-72 | Growth Inhibition Assay | IC50=0.53387 μM | SANGER | ||
| NH-12 | Growth Inhibition Assay | IC50=0.53959 μM | SANGER | ||
| SNB75 | Growth Inhibition Assay | IC50=0.5573 μM | SANGER | ||
| BPH-1 | Growth Inhibition Assay | IC50=0.56344 μM | SANGER | ||
| NOMO-1 | Growth Inhibition Assay | IC50=0.56372 μM | SANGER | ||
| G-402 | Growth Inhibition Assay | IC50=0.56499 μM | SANGER | ||
| NCI-H2052 | Growth Inhibition Assay | IC50=0.56741 μM | SANGER | ||
| RCM-1 | Growth Inhibition Assay | IC50=0.57166 μM | SANGER | ||
| COR-L279 | Growth Inhibition Assay | IC50=0.57185 μM | SANGER | ||
| A253 | Growth Inhibition Assay | IC50=0.57525 μM | SANGER | ||
| SK-MM-2 | Growth Inhibition Assay | IC50=0.57679 μM | SANGER | ||
| NCI-H1703 | Growth Inhibition Assay | IC50=0.59427 μM | SANGER | ||
| UACC-257 | Growth Inhibition Assay | IC50=0.59487 μM | SANGER | ||
| KALS-1 | Growth Inhibition Assay | IC50=0.60011 μM | SANGER | ||
| ES5 | Growth Inhibition Assay | IC50=0.6048 μM | SANGER | ||
| MHH-CALL-2 | Growth Inhibition Assay | IC50=0.60888 μM | SANGER | ||
| ChaGo-K-1 | Growth Inhibition Assay | IC50=0.61229 μM | SANGER | ||
| TGBC1TKB | Growth Inhibition Assay | IC50=0.6198 μM | SANGER | ||
| KU-19-19 | Growth Inhibition Assay | IC50=0.64586 μM | SANGER | ||
| COLO-684 | Growth Inhibition Assay | IC50=0.65611 μM | SANGER | ||
| LS-1034 | Growth Inhibition Assay | IC50=0.65819 μM | SANGER | ||
| RT-112 | Growth Inhibition Assay | IC50=0.66587 μM | SANGER | ||
| Capan-2 | Growth Inhibition Assay | IC50=0.66622 μM | SANGER | ||
| HSC-4 | Growth Inhibition Assay | IC50=0.66698 μM | SANGER | ||
| COLO-824 | Growth Inhibition Assay | IC50=0.67823 μM | SANGER | ||
| NCI-H2170 | Growth Inhibition Assay | IC50=0.68258 μM | SANGER | ||
| GDM-1 | Growth Inhibition Assay | IC50=0.68494 μM | SANGER | ||
| KP-4 | Growth Inhibition Assay | IC50=0.69573 μM | SANGER | ||
| VA-ES-BJ | Growth Inhibition Assay | IC50=0.69986 μM | SANGER | ||
| KM-H2 | Growth Inhibition Assay | IC50=0.70091 μM | SANGER | ||
| HH | Growth Inhibition Assay | IC50=0.70662 μM | SANGER | ||
| DK-MG | Growth Inhibition Assay | IC50=0.71016 μM | SANGER | ||
| VM-CUB-1 | Growth Inhibition Assay | IC50=0.71259 μM | SANGER | ||
| COLO-829 | Growth Inhibition Assay | IC50=0.71985 μM | SANGER | ||
| OMC-1 | Growth Inhibition Assay | IC50=0.72104 μM | SANGER | ||
| NB12 | Growth Inhibition Assay | IC50=0.72504 μM | SANGER | ||
| NCI-H28 | Growth Inhibition Assay | IC50=0.74083 μM | SANGER | ||
| A673 | Growth Inhibition Assay | IC50=0.75177 μM | SANGER | ||
| LB2241-RCC | Growth Inhibition Assay | IC50=0.76087 μM | SANGER | ||
| CCRF-CEM | Growth Inhibition Assay | IC50=0.77052 μM | SANGER | ||
| NCI-H510A | Growth Inhibition Assay | IC50=0.77186 μM | SANGER | ||
| SW48 | Growth Inhibition Assay | IC50=0.77333 μM | SANGER | ||
| NCI-H2081 | Growth Inhibition Assay | IC50=0.78147 μM | SANGER | ||
| RMG-I | Growth Inhibition Assay | IC50=0.78212 μM | SANGER | ||
| LU-99A | Growth Inhibition Assay | IC50=0.78413 μM | SANGER | ||
| KP-N-YS | Growth Inhibition Assay | IC50=0.78921 μM | SANGER | ||
| MDA-MB-231 | Growth Inhibition Assay | IC50=0.80131 μM | SANGER | ||
| U031 | Growth Inhibition Assay | IC50=0.81423 μM | SANGER | ||
| EVSA-T | Growth Inhibition Assay | IC50=0.81672 μM | SANGER | ||
| MDA-MB-157 | Growth Inhibition Assay | IC50=0.82271 μM | SANGER | ||
| EHEB | Growth Inhibition Assay | IC50=0.82276 μM | SANGER | ||
| KINGS-1 | Growth Inhibition Assay | IC50=0.82555 μM | SANGER | ||
| 23132-87 | Growth Inhibition Assay | IC50=0.82843 μM | SANGER | ||
| EFO-21 | Growth Inhibition Assay | IC50=0.84089 μM | SANGER | ||
| DOK | Growth Inhibition Assay | IC50=0.848 μM | SANGER | ||
| NCI-H2171 | Growth Inhibition Assay | IC50=0.8496 μM | SANGER | ||
| NCI-SNU-5 | Growth Inhibition Assay | IC50=0.8557 μM | SANGER | ||
| SK-N-DZ | Growth Inhibition Assay | IC50=0.85943 μM | SANGER | ||
| SNU-C2B | Growth Inhibition Assay | IC50=0.86801 μM | SANGER | ||
| CP66-MEL | Growth Inhibition Assay | IC50=0.8711 μM | SANGER | ||
| SN12C | Growth Inhibition Assay | IC50=0.88637 μM | SANGER | ||
| A172 | Growth Inhibition Assay | IC50=0.88698 μM | SANGER | ||
| NCI-H2347 | Growth Inhibition Assay | IC50=0.88753 μM | SANGER | ||
| NCI-H2228 | Growth Inhibition Assay | IC50=0.89339 μM | SANGER | ||
| SNU-387 | Growth Inhibition Assay | IC50=0.90264 μM | SANGER | ||
| SK-MEL-24 | Growth Inhibition Assay | IC50=0.91344 μM | SANGER | ||
| MDA-MB-468 | Growth Inhibition Assay | IC50=0.9173 μM | SANGER | ||
| NCI-H1694 | Growth Inhibition Assay | IC50=0.91876 μM | SANGER | ||
| CCF-STTG1 | Growth Inhibition Assay | IC50=0.92637 μM | SANGER | ||
| K052 | Growth Inhibition Assay | IC50=0.94047 μM | SANGER | ||
| NCI-H446 | Growth Inhibition Assay | IC50=0.9501 μM | SANGER | ||
| MFE-280 | Growth Inhibition Assay | IC50=0.96291 μM | SANGER | ||
| KU812 | Growth Inhibition Assay | IC50=0.99389 μM | SANGER | ||
| MDA-MB-361 | Growth Inhibition Assay | IC50=0.99777 μM | SANGER | ||
| Raji | Growth Inhibition Assay | IC50=1.02267 μM | SANGER | ||
| TE-6 | Growth Inhibition Assay | IC50=1.03566 μM | SANGER | ||
| CAL-148 | Growth Inhibition Assay | IC50=1.04443 μM | SANGER | ||
| NCI-H1963 | Growth Inhibition Assay | IC50=1.04553 μM | SANGER | ||
| SK-N-AS | Growth Inhibition Assay | IC50=1.04685 μM | SANGER | ||
| RERF-LC-MS | Growth Inhibition Assay | IC50=1.06349 μM | SANGER | ||
| BEN | Growth Inhibition Assay | IC50=1.07137 μM | SANGER | ||
| CAS-1 | Growth Inhibition Assay | IC50=1.09123 μM | SANGER | ||
| SW780 | Growth Inhibition Assay | IC50=1.09181 μM | SANGER | ||
| LU-65 | Growth Inhibition Assay | IC50=1.0941 μM | SANGER | ||
| D-283MED | Growth Inhibition Assay | IC50=1.12272 μM | SANGER | ||
| HCC2157 | Growth Inhibition Assay | IC50=1.13642 μM | SANGER | ||
| RCC10RGB | Growth Inhibition Assay | IC50=1.14006 μM | SANGER | ||
| PLC-PRF-5 | Growth Inhibition Assay | IC50=1.15229 μM | SANGER | ||
| H4 | Growth Inhibition Assay | IC50=1.15439 μM | SANGER | ||
| TUR | Growth Inhibition Assay | IC50=1.15752 μM | SANGER | ||
| NCI-H2141 | Growth Inhibition Assay | IC50=1.18946 μM | SANGER | ||
| PFSK-1 | Growth Inhibition Assay | IC50=1.20532 μM | SANGER | ||
| SK-MEL-28 | Growth Inhibition Assay | IC50=1.23221 μM | SANGER | ||
| SCC-9 | Growth Inhibition Assay | IC50=1.23665 μM | SANGER | ||
| T47D | Growth Inhibition Assay | IC50=1.23696 μM | SANGER | ||
| TCCSUP | Growth Inhibition Assay | IC50=1.25029 μM | SANGER | ||
| SU-DHL-1 | Growth Inhibition Assay | IC50=1.25118 μM | SANGER | ||
| HL-60 | Growth Inhibition Assay | IC50=1.25588 μM | SANGER | ||
| NCI-H1436 | Growth Inhibition Assay | IC50=1.26149 μM | SANGER | ||
| DMS-114 | Growth Inhibition Assay | IC50=1.26632 μM | SANGER | ||
| BOKU | Growth Inhibition Assay | IC50=1.28095 μM | SANGER | ||
| MS-1 | Growth Inhibition Assay | IC50=1.29069 μM | SANGER | ||
| NCI-H661 | Growth Inhibition Assay | IC50=1.30478 μM | SANGER | ||
| HT-3 | Growth Inhibition Assay | IC50=1.30529 μM | SANGER | ||
| CAL-54 | Growth Inhibition Assay | IC50=1.30725 μM | SANGER | ||
| SW1463 | Growth Inhibition Assay | IC50=1.31872 μM | SANGER | ||
| COLO-668 | Growth Inhibition Assay | IC50=1.33056 μM | SANGER | ||
| PANC-08-13 | Growth Inhibition Assay | IC50=1.33803 μM | SANGER | ||
| BB49-HNC | Growth Inhibition Assay | IC50=1.3401 μM | SANGER | ||
| M059J | Growth Inhibition Assay | IC50=1.35832 μM | SANGER | ||
| NCCIT | Growth Inhibition Assay | IC50=1.37988 μM | SANGER | ||
| LN-405 | Growth Inhibition Assay | IC50=1.39264 μM | SANGER | ||
| UMC-11 | Growth Inhibition Assay | IC50=1.39996 μM | SANGER | ||
| NB5 | Growth Inhibition Assay | IC50=1.41227 μM | SANGER | ||
| TE-441-T | Growth Inhibition Assay | IC50=1.42817 μM | SANGER | ||
| ME-180 | Growth Inhibition Assay | IC50=1.44392 μM | SANGER | ||
| HCC70 | Growth Inhibition Assay | IC50=1.46096 μM | SANGER | ||
| no-10 | Growth Inhibition Assay | IC50=1.46181 μM | SANGER | ||
| JEG-3 | Growth Inhibition Assay | IC50=1.50132 μM | SANGER | ||
| no-11 | Growth Inhibition Assay | IC50=1.50882 μM | SANGER | ||
| CHP-126 | Growth Inhibition Assay | IC50=1.56691 μM | SANGER | ||
| EGI-1 | Growth Inhibition Assay | IC50=1.58025 μM | SANGER | ||
| D-392MG | Growth Inhibition Assay | IC50=1.5963 μM | SANGER | ||
| RT4 | Growth Inhibition Assay | IC50=1.59637 μM | SANGER | ||
| A204 | Growth Inhibition Assay | IC50=1.59801 μM | SANGER | ||
| NCI-H1304 | Growth Inhibition Assay | IC50=1.63591 μM | SANGER | ||
| Becker | Growth Inhibition Assay | IC50=1.64241 μM | SANGER | ||
| OE19 | Growth Inhibition Assay | IC50=1.65518 μM | SANGER | ||
| EKVX | Growth Inhibition Assay | IC50=1.65618 μM | SANGER | ||
| KLE | Growth Inhibition Assay | IC50=1.65714 μM | SANGER | ||
| K-562 | Growth Inhibition Assay | IC50=1.67037 μM | SANGER | ||
| MDA-MB-175-VII | Growth Inhibition Assay | IC50=1.68997 μM | SANGER | ||
| NCI-H716 | Growth Inhibition Assay | IC50=1.69304 μM | SANGER | ||
| Caov-3 | Growth Inhibition Assay | IC50=1.69413 μM | SANGER | ||
| HCC1187 | Growth Inhibition Assay | IC50=1.70545 μM | SANGER | ||
| CAKI-1 | Growth Inhibition Assay | IC50=1.72292 μM | SANGER | ||
| MOLT-16 | Growth Inhibition Assay | IC50=1.73307 μM | SANGER | ||
| PC-3 | Growth Inhibition Assay | IC50=1.7508 μM | SANGER | ||
| DV-90 | Growth Inhibition Assay | IC50=1.75585 μM | SANGER | ||
| RXF393 | Growth Inhibition Assay | IC50=1.77294 μM | SANGER | ||
| SK-NEP-1 | Growth Inhibition Assay | IC50=1.82339 μM | SANGER | ||
| HCC1419 | Growth Inhibition Assay | IC50=1.82692 μM | SANGER | ||
| BV-173 | Growth Inhibition Assay | IC50=1.82995 μM | SANGER | ||
| MKN7 | Growth Inhibition Assay | IC50=1.8922 μM | SANGER | ||
| LAN-6 | Growth Inhibition Assay | IC50=1.89553 μM | SANGER | ||
| Mo-T | Growth Inhibition Assay | IC50=1.90039 μM | SANGER | ||
| HCC1395 | Growth Inhibition Assay | IC50=1.92863 μM | SANGER | ||
| HC-1 | Growth Inhibition Assay | IC50=1.9347 μM | SANGER | ||
| HPAF-II | Growth Inhibition Assay | IC50=1.94418 μM | SANGER | ||
| CPC-N | Growth Inhibition Assay | IC50=1.98002 μM | SANGER | ||
| MKN45 | Growth Inhibition Assay | IC50=1.99119 μM | SANGER | ||
| NCI-H1693 | Growth Inhibition Assay | IC50=2.00433 μM | SANGER | ||
| SHP-77 | Growth Inhibition Assay | IC50=2.00533 μM | SANGER | ||
| NCI-H1522 | Growth Inhibition Assay | IC50=2.01724 μM | SANGER | ||
| SW1573 | Growth Inhibition Assay | IC50=2.022 μM | SANGER | ||
| DBTRG-05MG | Growth Inhibition Assay | IC50=2.06087 μM | SANGER | ||
| SCC-4 | Growth Inhibition Assay | IC50=2.1431 μM | SANGER | ||
| DMS-153 | Growth Inhibition Assay | IC50=2.16668 μM | SANGER | ||
| MDA-MB-415 | Growth Inhibition Assay | IC50=2.1752 μM | SANGER | ||
| NCI-H2126 | Growth Inhibition Assay | IC50=2.22888 μM | SANGER | ||
| MDA-MB-453 | Growth Inhibition Assay | IC50=2.2332 μM | SANGER | ||
| U-87-MG | Growth Inhibition Assay | IC50=2.28592 μM | SANGER | ||
| LNCaP-Clone-FGC | Growth Inhibition Assay | IC50=2.30102 μM | SANGER | ||
| NCI-H1581 | Growth Inhibition Assay | IC50=2.32105 μM | SANGER | ||
| BC-3 | Growth Inhibition Assay | IC50=2.36509 μM | SANGER | ||
| HCC38 | Growth Inhibition Assay | IC50=2.38447 μM | SANGER | ||
| HCC2218 | Growth Inhibition Assay | IC50=2.40809 μM | SANGER | ||
| RO82-W-1 | Growth Inhibition Assay | IC50=2.4125 μM | SANGER | ||
| C2BBe1 | Growth Inhibition Assay | IC50=2.41578 μM | SANGER | ||
| LAMA-84 | Growth Inhibition Assay | IC50=2.57368 μM | SANGER | ||
| GMS-10 | Growth Inhibition Assay | IC50=2.57611 μM | SANGER | ||
| GCT | Growth Inhibition Assay | IC50=2.58694 μM | SANGER | ||
| SK-CO-1 | Growth Inhibition Assay | IC50=2.6166 μM | SANGER | ||
| NCI-H526 | Growth Inhibition Assay | IC50=2.6345 μM | SANGER | ||
| SW1088 | Growth Inhibition Assay | IC50=2.77839 μM | SANGER | ||
| HT55 | Growth Inhibition Assay | IC50=2.78695 μM | SANGER | ||
| NB10 | Growth Inhibition Assay | IC50=2.81748 μM | SANGER | ||
| UACC-893 | Growth Inhibition Assay | IC50=2.85749 μM | SANGER | ||
| NCI-H1618 | Growth Inhibition Assay | IC50=2.88153 μM | SANGER | ||
| NCI-H1092 | Growth Inhibition Assay | IC50=3.07812 μM | SANGER | ||
| SBC-1 | Growth Inhibition Assay | IC50=3.08553 μM | SANGER | ||
| NCI-H1623 | Growth Inhibition Assay | IC50=3.0934 μM | SANGER | ||
| SiHa | Growth Inhibition Assay | IC50=3.11977 μM | SANGER | ||
| D-263MG | Growth Inhibition Assay | IC50=3.14788 μM | SANGER | ||
| NCI-H1573 | Growth Inhibition Assay | IC50=3.19641 μM | SANGER | ||
| NCI-H82 | Growth Inhibition Assay | IC50=3.34439 μM | SANGER | ||
| NCI-H2196 | Growth Inhibition Assay | IC50=3.35008 μM | SANGER | ||
| MFM-223 | Growth Inhibition Assay | IC50=3.37351 μM | SANGER | ||
| COLO-678 | Growth Inhibition Assay | IC50=3.38186 μM | SANGER | ||
| EW-3 | Growth Inhibition Assay | IC50=3.4095 μM | SANGER | ||
| MHH-NB-11 | Growth Inhibition Assay | IC50=3.44069 μM | SANGER | ||
| EM-2 | Growth Inhibition Assay | IC50=3.6398 μM | SANGER | ||
| FTC-133 | Growth Inhibition Assay | IC50=3.65458 μM | SANGER | ||
| NCI-H209 | Growth Inhibition Assay | IC50=3.67653 μM | SANGER | ||
| TGBC24TKB | Growth Inhibition Assay | IC50=3.68355 μM | SANGER | ||
| LC-1F | Growth Inhibition Assay | IC50=3.71764 μM | SANGER | ||
| C-4-II | Growth Inhibition Assay | IC50=3.75643 μM | SANGER | ||
| NCI-H1650 | Growth Inhibition Assay | IC50=3.78455 μM | SANGER | ||
| JVM-2 | Growth Inhibition Assay | IC50=3.93639 μM | SANGER | ||
| CaR-1 | Growth Inhibition Assay | IC50=3.97617 μM | SANGER | ||
| MDA-MB-134-VI | Growth Inhibition Assay | IC50=4.02952 μM | SANGER | ||
| NCI-H719 | Growth Inhibition Assay | IC50=4.15388 μM | SANGER | ||
| GOTO | Growth Inhibition Assay | IC50=4.29705 μM | SANGER | ||
| NCI-N87 | Growth Inhibition Assay | IC50=4.38821 μM | SANGER | ||
| NB6 | Growth Inhibition Assay | IC50=4.42509 μM | SANGER | ||
| DSH1 | Growth Inhibition Assay | IC50=4.47116 μM | SANGER | ||
| BT-20 | Growth Inhibition Assay | IC50=4.49002 μM | SANGER | ||
| NCI-H1882 | Growth Inhibition Assay | IC50=4.5057 μM | SANGER | ||
| WM-115 | Growth Inhibition Assay | IC50=4.50881 μM | SANGER | ||
| SKG-IIIa | Growth Inhibition Assay | IC50=4.6777 μM | SANGER | ||
| NCI-H69 | Growth Inhibition Assay | IC50=4.70275 μM | SANGER | ||
| MSTO-211H | Growth Inhibition Assay | IC50=4.83565 μM | SANGER | ||
| Mewo | Growth Inhibition Assay | IC50=4.96313 μM | SANGER | ||
| GI-ME-N | Growth Inhibition Assay | IC50=5.00509 μM | SANGER | ||
| T98G | Growth Inhibition Assay | IC50=5.06508 μM | SANGER | ||
| ECC4 | Growth Inhibition Assay | IC50=5.09372 μM | SANGER | ||
| EW-11 | Growth Inhibition Assay | IC50=5.18099 μM | SANGER | ||
| COLO-800 | Growth Inhibition Assay | IC50=5.19349 μM | SANGER | ||
| NCI-H1755 | Growth Inhibition Assay | IC50=5.23027 μM | SANGER | ||
| KMS-12-PE | Growth Inhibition Assay | IC50=5.35085 μM | SANGER | ||
| HCC1954 | Growth Inhibition Assay | IC50=5.85971 μM | SANGER | ||
| NCI-H187 | Growth Inhibition Assay | IC50=5.92989 μM | SANGER | ||
| LU-165 | Growth Inhibition Assay | IC50=5.99002 μM | SANGER | ||
| YAPC | Growth Inhibition Assay | IC50=5.99068 μM | SANGER | ||
| LU-139 | Growth Inhibition Assay | IC50=6.08368 μM | SANGER | ||
| D-502MG | Growth Inhibition Assay | IC50=6.32047 μM | SANGER | ||
| IST-SL1 | Growth Inhibition Assay | IC50=6.53948 μM | SANGER | ||
| DG-75 | Growth Inhibition Assay | IC50=6.88786 μM | SANGER | ||
| NCI-H1155 | Growth Inhibition Assay | IC50=6.95581 μM | SANGER | ||
| EFE-184 | Growth Inhibition Assay | IC50=7.31695 μM | SANGER | ||
| AsPC-1 | Growth Inhibition Assay | IC50=7.48807 μM | SANGER | ||
| SW948 | Growth Inhibition Assay | IC50=7.58395 μM | SANGER | ||
| NCI-H524 | Growth Inhibition Assay | IC50=9.58628 μM | SANGER | ||
| KOSC-2 | Growth Inhibition Assay | IC50=9.62834 μM | SANGER | ||
| T-24 | Growth Inhibition Assay | IC50=9.94415 μM | SANGER | ||
| NCI-H748 | Growth Inhibition Assay | IC50=10.6397 μM | SANGER | ||
| NCI-H23 | Growth Inhibition Assay | IC50=10.6442 μM | SANGER | ||
| UACC-812 | Growth Inhibition Assay | IC50=11.717 μM | SANGER | ||
| SCLC-21H | Growth Inhibition Assay | IC50=12.1551 μM | SANGER | ||
| NCI-SNU-16 | Growth Inhibition Assay | IC50=13.1258 μM | SANGER | ||
| HD-MY-Z | Growth Inhibition Assay | IC50=14.6363 μM | SANGER | ||
| SK-N-FI | Growth Inhibition Assay | IC50=14.8912 μM | SANGER | ||
| LB647-SCLC | Growth Inhibition Assay | IC50=15.7195 μM | SANGER | ||
| NCI-H345 | Growth Inhibition Assay | IC50=17.343 μM | SANGER | ||
| NCI-H1563 | Growth Inhibition Assay | IC50=18.7601 μM | SANGER | ||
| RL | Growth Inhibition Assay | IC50=21.2656 μM | SANGER | ||
| KY821 | Growth Inhibition Assay | IC50=22.0553 μM | SANGER | ||
| JVM-3 | Growth Inhibition Assay | IC50=25.0413 μM | SANGER | ||
| NCI-H1793 | Growth Inhibition Assay | IC50=28.5499 μM | SANGER | ||
| LU-134-A | Growth Inhibition Assay | IC50=30.2037 μM | SANGER | ||
| NCI-H1395 | Growth Inhibition Assay | IC50=32.2431 μM | SANGER | ||
| NCI-H1993 | Growth Inhibition Assay | IC50=32.8218 μM | SANGER | ||
| P31-FUJ | Growth Inhibition Assay | IC50=33.4899 μM | SANGER | ||
| LS-513 | Growth Inhibition Assay | IC50=35.8879 μM | SANGER | ||
| SK-MEL-1 | Growth Inhibition Assay | IC50=40.3499 μM | SANGER | ||
| SW684 | Growth Inhibition Assay | IC50=43.9661 μM | SANGER | ||
| COR-L88 | Growth Inhibition Assay | IC50=44.0665 μM | SANGER | ||
| NCI-H889 | Growth Inhibition Assay | IC50=45.0087 μM | SANGER | ||
| TALL-1 | Growth Inhibition Assay | IC50=46.1199 μM | SANGER | ||
| KARPAS-299 | Growth Inhibition Assay | IC50=47.1993 μM | SANGER | ||
| 他の多くの細胞株試験データをご覧になる場合はこちらをクリックして下さい | |||||
生物活性
| 製品説明 | Obatoclax Mesylate (GX15-070) is an antagonist of Bcl-2 with Ki of 0.22 μM in a cell-free assay, can assist in overcoming MCL-1 mediated resistance to apoptosis. | ||
|---|---|---|---|
| 特性 | Potential 1st-in-class small molecule antagonist of Bcl-2 designed to inhibit all relevant Bcl-2 family members, including Mcl-1. | ||
| Targets |
|
| In Vitro | ||||
| In vitro |
Obatoclax completely inhibits Bak recovery of Mcl-1 at 5 μM in SK-Mel5 cells and overcomes resistance to ABT-373-induced apoptosis conferred by Mcl-1 in KB/Bcl-2 cells. [1] Obatoclax is a BH3 mimetic which binds to a broad spectrum of Bcl-2 family members, including Bcl-2, Bcl-xL, and Mcl-1. Obatoclax uniquely displaces BH3 domains by activation of the pocket of Mcl-1 followed by a triggering of apoptosis mediated by oligomerization of Bak and release of cytochrome c. Obatoclax is sensitive to Bcl-xL in cell lines lacking it or showing low expression. It shows low cytotoxicity to Mcl-1, Bcl-2, and Bcl-xL in all the strongly-expressed cell lines. Obatoclax inhibits multiple myeloma (MM) cell lines (KMS12PE, KMS18, MY5, etc.) with IC50 values ranging from 52 to 1100 nM and the inhibition is umimpaired even in the presence of IL-6 or IGF-1, which are resistance to cytotoxic agents, at a concentration of 150 nM. [2] Obatoclax potentiates TRAIL (tumor necrosis factor-related apoptosis-inducing ligand)-mediated apoptosis by unsequestering Bak and Bim from Bcl-2/Bcl-xL or Mcl-1 proteins in PANC-1 and BxPC-3 cells. [3] |
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|---|---|---|---|---|
| Kinase Assay | Bcl-2 Binding affinity calculation | |||
| A predicted binding affinity for Obatoclax binding to BCL-2 is calculated using the SIE scoring function. [4] As a control in determining the reliability of the calculation, predicted binding affinities Ki) are calculated for a set of 12 small molecules with experimentally measured binding affinities to BCL-2. | ||||
| 細胞実験 | 細胞株 | Human MM cells (HMCLs), peripheral blood lymphocytes (PBLs), bone marrow stromal cells (BMSCs) | ||
| 濃度 | ~10 μM | |||
| 反応時間 | 48-72 hours | |||
| 実験の流れ | Obatoclax is dissolved in DMSO at a stock concentration of 5 mM. Cell viability is assayed by MTT. Human MM cells (HMCLs), peripheral blood lymphocytes (PBLs), bone marrow stromal cells (BMSCs) are seeded in 96-well plates at a density of 2 × 104 per well for HMCLs or 5~10 × 103 for PBLs. Various concentrations of Obatoclax are added to the cells, with or without IGF-1 (50 ng/mL) or IL-6 (10 ng/mL). Cells are incubated for 48-72 hours and cell viability is determined. |
|||
| 実験結果図 | Methods | Biomarkers | 結果図 | PMID |
| Western blot | Cyclin D1 / p27 Kip1 p-Cyclin D1 p-GSK3β / GSK3β / p-ERK / ERK / p-p38 / p38 |
|
28382170 | |
| Growth inhibition assay | Cell proliferation Cell viability |
|
28035994 | |
| In Vivo | ||
| In Vivo |
Obatoclax also exhibits high antitumor activity in SCID mice bearing human C33A cerivical carcinoma tumors at a dose of 0.5 mg/kg. [1] |
|
|---|---|---|
| 動物実験 | 動物モデル | Female BALB/c or CB17 SCID/SCID mice bearing SW480, C33A, PC3, and 4T1 cells are used. |
| 投与量 | 0.0313, 0.25, 0.5 and 2 mg/kg | |
| 投与経路 | Administered intravenously (tail vein) once a day | |
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT00438178 | Completed | Hematological Malignancies |
Gemin X|Teva Branded Pharmaceutical Products R&D Inc. |
October 2005 | Phase 1 |
| NCT00600964 | Completed | Chronic Lymphocytic Leukemia |
Gemin X|Teva Branded Pharmaceutical Products R&D Inc. |
September 2004 | Phase 1 |
化学情報
| 分子量 | 413.49 | 化学式 | C20H19N3O.CH4O3S |
| CAS No. | 803712-79-0 | SDF | Download Obatoclax Mesylate (GX15-070) SDFをダウンロードする |
| Smiles | CC1=CC(=C(N1)C=C2C(=CC(=C3C=C4C=CC=CC4=N3)N2)OC)C.CS(=O)(=O)O | ||
| 保管 | |||
|
In vitro |
DMSO : 83 mg/mL ( (200.73 mM)； 吸湿したDMSOは溶解度を減少させます。新しいDMSOをご使用ください。) Water : Insoluble Ethanol : Insoluble |
モル濃度計算器 |
|
in vivo Add solvents to the product individually and in order. |
投与溶液組成計算機 | ||||
実験計算
投与溶液組成計算機(クリア溶液)
ステップ１：実験データを入力してください。（実験操作によるロスを考慮し、動物数を1匹分多くして計算・調製することを推奨します）
mg/kg
g
μL
匹
ステップ２：投与溶媒の組成を入力してください。（ロット毎に適した溶解組成が異なる場合があります。詳細については弊社までお問い合わせください）
% DMSO
%
% Tween 80
% ddH2O
%DMSO
%
計算結果：
投与溶媒濃度： mg/ml;
DMSOストック溶液調製方法： mg 試薬を μL DMSOに溶解する（濃度 mg/mL, 注：濃度が当該ロットのDMSO溶解度を超える場合はご連絡ください。 )
投与溶媒調製方法：Take μL DMSOストック溶液に μL PEG300，を加え、完全溶解後μL Tween 80，を加えて完全溶解させた後 μL ddH2O，を加え完全に溶解させます。
投与溶媒調製方法：μL DMSOストック溶液に μL Corn oil，を加え、完全溶解。
注意：１.ストック溶液に沈殿、混濁などがないことをご確認ください；
２.順番通りに溶剤を加えてください。次のステップに進む前に溶液に沈殿、混濁などがないことを確認してから加えてください。ボルテックス、ソニケーション、水浴加熱など物理的な方法で溶解を早めることは可能です。
技術サポート
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