BT474 |
Function assay |
7.5 uM |
3 days |
Disruption of preformed spheroids in human BT474 cancer stem cells at 7.5 uM after 3 days by microscopic analysis |
ChEMBL |
DU145 |
Function assay |
7.5 uM |
3 days |
Disruption of preformed spheroids in human DU145 cancer stem cells at 7.5 uM after 3 days by microscopic analysis |
ChEMBL |
HT-29 cells |
Proliferation assay |
|
72 h |
Antiproliferative activity against human HT-29 cells assessed as growth inhibition after 72 hrs by SRB method, IC50=1.03 μM |
25644674 |
LS180 cells |
Proliferation assay |
|
72 h |
Antiproliferative activity against human LS180 cells assessed as growth inhibition after 72 hrs by SRB method, IC50=0.61 μM |
25644674 |
LoVo cells |
Proliferation assay |
|
72 h |
Antiproliferative activity against human LoVo cells assessed as growth inhibition after 72 hrs by SRB method, IC50=0.36 μM |
25644674 |
MV4-11 cells |
Proliferation assay |
|
72 h |
Antiproliferative activity against human MV4-11 cells after 72 hrs, IC50=0.33 μM |
26163197 |
HL60 cells |
Proliferation assay |
|
72 h |
Antiproliferative activity against human HL60 cells assessed as growth inhibition after 72 hrs by MTT assay, IC50=0.29 μM |
25644674 |
SW707 cells |
Proliferation assay |
|
72 h |
Antiproliferative activity against human SW707 cells assessed as growth inhibition after 72 hrs by SRB method, IC50=1.73 μM |
25644674 |
HL60/Vinc cells |
Cytotoxicity assay |
|
72 h |
Cytotoxicity against vincristine-resistant human HL60/Vinc cells incubated for 72 hrs by MTT assay, IC50=3.44 μM |
23079523 |
BALB/3T3 cells |
Cytotoxicity assay |
|
72 h |
Cytotoxicity against mouse BALB/3T3 cells incubated for 72 hrs by MTT assay, IC50=28.08 μM |
23079523 |
HL60 |
Cytotoxicity assay |
|
72 hrs |
Cytotoxicity against human HL60 cells incubated for 72 hrs by MTT assay, IC50 = 0.44 μM. |
23079523 |
LoVo |
Cytotoxicity assay |
|
72 hrs |
Cytotoxicity against human LoVo cells incubated for 72 hrs by MTT assay, IC50 = 1.11 μM. |
23079523 |
HL60/Vinc |
Cytotoxicity assay |
|
72 hrs |
Cytotoxicity against vincristine-resistant human HL60/Vinc cells incubated for 72 hrs by MTT assay, IC50 = 3.44 μM. |
23079523 |
LoVo/DX |
Cytotoxicity assay |
|
72 hrs |
Cytotoxicity against doxorubicin-resistant human LoVo/DX cells incubated for 72 hrs by MTT assay, IC50 = 6.23 μM. |
23079523 |
BALB/3T3 |
Cytotoxicity assay |
|
72 hrs |
Cytotoxicity against mouse BALB/3T3 cells incubated for 72 hrs by MTT assay, IC50 = 28.08 μM. |
23079523 |
HL60 |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human HL60 cells assessed as growth inhibition after 72 hrs by MTT assay, IC50 = 0.29 μM. |
25644674 |
LoVo |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human LoVo cells assessed as growth inhibition after 72 hrs by SRB method, IC50 = 0.36 μM. |
25644674 |
LS180 |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human LS180 cells assessed as growth inhibition after 72 hrs by SRB method, IC50 = 0.61 μM. |
25644674 |
LoVo/DX |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human doxorubicin-resistant LoVo/DX cells assessed as growth inhibition after 72 hrs by SRB method, IC50 = 0.76 μM. |
25644674 |
HT-29 |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human HT-29 cells assessed as growth inhibition after 72 hrs by SRB method, IC50 = 1.03 μM. |
25644674 |
SW707 |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human SW707 cells assessed as growth inhibition after 72 hrs by SRB method, IC50 = 1.73 μM. |
25644674 |
HL60/Vinc |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human vincristine-resistant HL60/Vinc cells assessed as growth inhibition after 72 hrs by MTT assay, IC50 = 2.09 μM. |
25644674 |
BALB/3T3 |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against mouse BALB/3T3 cells assessed as growth inhibition after 72 hrs by SRB method, IC50 = 9.33 μM. |
25644674 |
MV4-11 |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human MV4-11 cells after 72 hrs, IC50 = 0.33 μM. |
26163197 |
LoVo |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human LoVo cells after 72 hrs, IC50 = 0.53 μM. |
26163197 |
LoVo/DX |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against doxorubicin-resistant human LoVo/DX cells after 72 hrs, IC50 = 0.59 μM. |
26163197 |
BALB/3T3 |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against mouse BALB/3T3 cells after 72 hrs, IC50 = 27.76 μM. |
26163197 |
JIMT1 |
Cytotoxicity assay |
|
72 hrs |
Cytotoxicity against human JIMT1 cells after 72 hrs by MTT assay, IC50 = 0.52 μM. |
27326340 |
MCF7 |
Cytotoxicity assay |
|
72 hrs |
Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay, IC50 = 0.59 μM. |
27326340 |
MCF7 |
Antiproliferative assay |
|
48 hrs |
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay, IC50 = 2.98 μM. |
27876192 |
MDA-MB-231 |
Antiproliferative assay |
|
48 hrs |
Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay, IC50 = 6.42 μM. |
27876192 |
MIAPaCa2 |
Cytotoxicity assay |
|
48 hrs |
Cytotoxicity against human MIAPaCa2 cells assessed as decrease in cell viability after 48 hrs by MTS assay |
28177244 |
DU145 |
Cytotoxicity assay |
|
48 hrs |
Cytotoxicity against human DU145 cells assessed as decrease in cell viability after 48 hrs by MTS assay |
28177244 |
BT474 |
Cytotoxicity assay |
|
48 hrs |
Cytotoxicity against human BT474 cells assessed as decrease in cell viability after 48 hrs by MTS assay |
28177244 |
MDA-MB-231 |
Cytotoxicity assay |
|
48 hrs |
Cytotoxicity against human MDA-MB-231 cells assessed as decrease in cell viability after 48 hrs by MTS assay |
28177244 |
HT-29 |
Cytotoxicity assay |
|
48 hrs |
Cytotoxicity against human HT-29 cells assessed as decrease in cell proliferation after 48 hrs by MTT assay, IC50 = 1.43 μM. |
28262526 |
HGC27 |
Cytotoxicity assay |
|
48 hrs |
Cytotoxicity against human HGC27 cells assessed as decrease in cell proliferation after 48 hrs by MTT assay, IC50 = 2.57 μM. |
28262526 |
MDA-MB-231 |
Cytotoxicity assay |
|
48 hrs |
Cytotoxicity against human MDA-MB-231 cells assessed as decrease in cell proliferation after 48 hrs by MTT assay, IC50 = 6.53 μM. |
28262526 |
OV2008 |
Cytotoxicity assay |
|
72 hrs |
Cytotoxicity against human OV2008 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay, IC50 = 3.2 μM. |
28651817 |
OV2008 |
Cytotoxicity assay |
|
48 hrs |
Cytotoxicity against human OV2008 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay, IC50 = 4.78 μM. |
28651817 |
OV2008 |
Cytotoxicity assay |
|
24 hrs |
Cytotoxicity against human OV2008 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay, IC50 = 7.44 μM. |
28651817 |
HT-29 |
Antiproliferative assay |
|
48 hrs |
Antiproliferative activity against human HT-29 cells after 48 hrs by MTT assay, IC50 = 1.43 μM. |
28688275 |
HEK293 |
Cytotoxicity assay |
|
72 hrs |
Cytotoxicity against HEK293 cells assessed as cell growth inhibition after 72 hrs by MTT assay, IC50 = 0.195 μM. |
29466777 |
HEK293 |
Cytotoxicity assay |
|
72 hrs |
Cytotoxicity against doxycycline inducible T-Rex/K-Ras G12V HEK293 cells assessed as cell growth inhibition after 72 hrs by MTT assay, IC50 = 0.3295 μM. |
29466777 |
HL60 |
Cytotoxicity assay |
|
48 hrs |
Cytotoxicity against human HL60 cells assessed as cell growth inhibition after 48 hrs by MTS assay, IC50 = 0.58 μM. |
29466777 |
SW480 |
Cytotoxicity assay |
|
48 hrs |
Cytotoxicity against human SW480 cells assessed as cell growth inhibition after 48 hrs by MTS assay, IC50 = 3.77 μM. |
29466777 |
4T1 |
Cytotoxicity assay |
|
48 hrs |
Cytotoxicity against mouse 4T1 cells assessed as cell growth inhibition after 48 hrs by MTS assay, IC50 = 3.78 μM. |
29466777 |
A549 |
Cytotoxicity assay |
|
48 hrs |
Cytotoxicity against human A549 cells assessed as cell growth inhibition after 48 hrs by MTS assay, IC50 = 3.98 μM. |
29466777 |
HeLa |
Cytotoxicity assay |
|
48 hrs |
Cytotoxicity against human HeLa cells assessed as cell growth inhibition after 48 hrs by MTS assay, IC50 = 4.49 μM. |
29466777 |
MCF7 |
Cytotoxicity assay |
|
48 hrs |
Cytotoxicity against human MCF7 cells assessed as cell growth inhibition after 48 hrs by MTS assay, IC50 = 9.08 μM. |
29466777 |
SMMC7721 |
Cytotoxicity assay |
|
48 hrs |
Cytotoxicity against human SMMC7721 cells assessed as cell growth inhibition after 48 hrs by MTS assay, IC50 = 12.04 μM. |
29466777 |
BEAS2B |
Cytotoxicity assay |
|
48 hrs |
Cytotoxicity against human BEAS2B cells assessed as cell growth inhibition after 48 hrs by MTS assay, IC50 = 13.07 μM. |
29466777 |
LoVo |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human LoVo cells after 72 hrs by SRB assay, IC50 = 0.44 μM. |
30025346 |
LoVo/DX |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human LoVo/DX cells after 72 hrs by SRB assay, IC50 = 0.69 μM. |
30025346 |
SK-BR-3 |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human SK-BR-3 cells after 72 hrs by SRB assay, IC50 = 0.89 μM. |
30025346 |
JIMT1 |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human JIMT1 cells after 72 hrs by SRB assay, IC50 = 1.3 μM. |
30025346 |
MCF7 |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human MCF7 cells after 72 hrs by SRB assay, IC50 = 1.5 μM. |
30025346 |
ALL5 |
Antiproliferative assay |
|
120 hrs |
Antiproliferative activity against human ALL5 cells after 120 hrs by MTT assay, IC50 = 2.4 μM. |
30025346 |
MCF10A |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human MCF10A cells after 72 hrs by SRB assay, IC50 = 46 μM. |
30025346 |
HT-29 |
Antiproliferative assay |
|
48 hrs |
Antiproliferative activity against human HT-29 cells after 48 hrs by MTT assay, IC50 = 3.21 μM. |
30684870 |
HGC27 |
Antiproliferative assay |
|
48 hrs |
Antiproliferative activity against human HGC27 cells after 48 hrs by MTT assay, IC50 = 8.18 μM. |
30684870 |
HepG2 |
Cytotoxicity assay |
|
72 hrs |
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay, IC50 = 24.5 μM. |
30871771 |
HL60 |
Cytotoxicity assay |
|
24 hrs |
Cytotoxicity against human HL60 cells assessed as growth inhibition after 24 hrs by resazurin dye based assay, GI50 = 6.63 μM. |
30986574 |
HL-60 |
Function assay |
|
24 hrs |
Trypanocidal activity against bloodstream forms of Trypanosoma brucei infected in human HL-60 cells incubated for 24 hrs followed by compound wash out after 72 hrs, GI50 = 0.18 μM. |
31103901 |
MDCK |
Antiviral assay |
|
3 days |
Antiviral activity against Influenza A virus (A/Hong Kong/7/1987(H3N2)) infected in MDCK cells after 3 days by MTT assay, EC50 = 0.4 μM. |
31103901 |
Vero |
Antiviral assay |
|
24 hrs |
Antiviral activity against SARS-CoV-2 (viral titer) measured by plaque assay in Vero cells at MOI 0.0125 after 24 hr, IC50 = 0.24 μM. |
ChEMBL |
MIAPaCa2 |
Cytotoxicity assay |
|
48 hrs |
Cytotoxicity against human MIAPaCa2 cells after 48 hrs by MTS assay, CC50 = 6.5 μM. |
ChEMBL |
BT474 |
Cytotoxicity assay |
|
48 hrs |
Cytotoxicity against human BT474 cells after 48 hrs by MTS assay, CC50 = 14 μM. |
ChEMBL |
VCaP cells |
Proliferation assay |
|
|
Antiproliferative activity against human VCaP cells, EC50=0.38 μM |
23063400 |
VCaP |
Antiproliferative assay |
|
|
Antiproliferative activity against human VCaP cells, EC50 = 0.38 μM. |
23063400 |
LoVo/DX |
Antiproliferative assay |
|
|
Antiproliferative activity against human LoVo/DX cells, IC50 = 1 μM. |
24631190 |
HL60 |
Antiproliferative assay |
|
|
Antiproliferative activity against human HL60 cells, IC50 = 1.2 μM. |
24631190 |
LoVo |
Antiproliferative assay |
|
|
Antiproliferative activity against human LoVo cells, IC50 = 1.5 μM. |
24631190 |
HL60/Vinc |
Antiproliferative assay |
|
|
Antiproliferative activity against human HL60/Vinc cells, IC50 = 4.7 μM. |
24631190 |
BALB/3T3 |
Antiproliferative assay |
|
|
Antiproliferative activity mouse BALB/3T3 cells, IC50 = 25.8 μM. |
24631190 |
HMLER |
Antiproliferative assay |
|
|
Antiproliferative activity against HMLER cells by MTT assay Breast cancer stem cell, IC50 = 0.1 μM. |
30684870 |
HeLa |
Antiproliferative assay |
|
|
Antiproliferative activity against human HeLa cells by MTT assay, IC50 = 0.32 μM. |
30684870 |
LoVo |
Antiproliferative assay |
|
|
Antiproliferative activity against human LoVo cells by SRB assay, IC50 = 0.44 μM. |
30684870 |
JIMT1 |
Antiproliferative assay |
|
|
Antiproliferative activity against human JIMT1 cells, IC50 = 0.52 μM. |
30684870 |
JIMT1 |
Antiproliferative assay |
|
|
Antiproliferative activity against human JIMT1 cells by MTT assay, IC50 = 0.52 μM. |
30684870 |
MCF7 |
Antiproliferative assay |
|
|
Antiproliferative activity against human MCF7 cells by MTT assay, IC50 = 0.59 μM. |
30684870 |
LoVo/DX |
Antiproliferative assay |
|
|
Antiproliferative activity against human LoVo/DX cells by SRB assay, IC50 = 0.69 μM. |
30684870 |
SKBR3 |
Antiproliferative assay |
|
|
Antiproliferative activity against human SKBR3 cells by SRB assay, IC50 = 0.89 μM. |
30684870 |
HT-29 |
Antiproliferative assay |
|
|
Antiproliferative activity against human HT-29 cells by MTT assay, IC50 = 1.03 μM. |
30684870 |
JIMT1 |
Antiproliferative assay |
|
|
Antiproliferative activity against human JIMT1 cells by SRB assay, IC50 = 1.3 μM. |
30684870 |
MCF7 |
Antiproliferative assay |
|
|
Antiproliferative activity against human MCF7 cells by SRB assay, IC50 = 1.5 μM. |
30684870 |
HGC27 |
Antiproliferative assay |
|
|
Antiproliferative activity against human HGC27 cells by MTT assay, IC50 = 2.57 μM. |
30684870 |
4T1 |
Antiproliferative assay |
|
|
Antiproliferative activity against mouse 4T1 cells by MTT assay, IC50 = 3.78 μM. |
30684870 |
A549 |
Antiproliferative assay |
|
|
Antiproliferative activity against human A549 cells by MTT assay, IC50 = 3.98 μM. |
30684870 |
MDA-MB-231 |
Antiproliferative assay |
|
|
Antiproliferative activity against human MDA-MB-231 cells by SRB assay, IC50 = 6.42 μM. |
30684870 |
MDA-MB-231 |
Antiproliferative assay |
|
|
Antiproliferative activity against human MDA-MB-231 cells by MTT assay, IC50 = 6.91 μM. |
30684870 |
Caco2 |
Antiproliferative assay |
|
|
Antiproliferative activity against human Caco2 cells by MTT assay, IC50 = 12.99 μM. |
30684870 |
U87 |
Antiproliferative assay |
|
|
Antiproliferative activity against human U87 cells by MTT assay, IC50 = 38.7 μM. |
30684870 |
MCF10A |
Antiproliferative assay |
|
|
Antiproliferative activity against human MCF10A cells by SRB assay, IC50 = 46 μM. |
30684870 |