A549 |
Function assay |
10 uM |
4 hrs |
Reduction in total GSH level in human A549 cells at 10 uM after 4 hrs by luminescence assay |
25826398 |
A549 |
Function assay |
10 uM |
4 hrs |
Reduction in reduced GSH level in human A549 cells at 10 uM after 4 hrs by luminescence assay |
25826398 |
U937 |
Apoptosis assay |
2 uM |
24 hrs |
Induction of apoptosis in p53 null human U937 cells assessed as caspase 3 cleavage at 2 uM after 24 hrs in presence of SAHA by Western blot analysis |
27505848 |
U937 |
Apoptosis assay |
2 uM |
24 hrs |
Induction of apoptosis in p53 null human U937 cells assessed as PARP-1 cleavage at 2 uM after 24 hrs in presence of SAHA by Western blot analysis |
27505848 |
U937 |
Cell death assay |
1 to 4 uM |
24 hrs |
Induction of cell death in p53 null human U937 cells at 1 to 4 uM after 24 hrs by annexin V-FITC/PI staining based flow cytometry |
27505848 |
U937 |
Cytotoxicity assay |
0.5 to 5 uM |
24 hrs |
Cytotoxicity against p53 null human U937 cells assessed as decrease in cell viability at 0.5 to 5 uM after 24 hrs in presence of SAHA by MTT assay |
27505848 |
U937 |
Function assay |
2 uM |
20 hrs |
Induction of DNA damage in p53 null human U937 cells at 2 uM after 20 hrs in presence of SAHA by SYBR gold staining based alkaline comet assay |
27505848 |
MCF7 |
Apoptosis assay |
10 uM |
48 hrs |
Induction of apoptosis in human MCF7 cells assessed as downregulation of Bcl2 expression at 10 uM after 48 hrs by Western blot method |
27689728 |
MCF7 |
Apoptosis assay |
10 uM |
72 hrs |
Induction of apoptosis in human MCF7 cells assessed as downregulation of Mcl-1 expression at 10 uM after 72 hrs by Western blot method |
27689728 |
MCF7 |
Function assay |
20 uM |
16 hrs |
Disruption of microtubule network in human MCF7 cells at 20 uM after 16 hrs by immunofluorescence analysis |
27689728 |
MCF7 |
Function assay |
10 uM |
16 hrs |
Induction of microtubule depolymerization in human MCF7 cells at 10 uM after 16 hrs by immunofluorescence analysis |
27689728 |
MCF7 |
Function assay |
1 to 20 uM |
48 hrs |
Induction of reactive oxygen species generation in human MCF7 cells assessed as decrease in cell viability at 1 to 20 uM in presence of trolox after 48 hrs by alamarBlue assay |
27689728 |
MCF7 |
Function assay |
5 to 20 uM |
4 hrs |
Induction of tubulin depolymerization in human MCF7 cells at 5 to 20 uM after 4 hrs by Western blot method |
27689728 |
Jurkat |
Function assay |
5 to 20 uM |
4 hrs |
Induction of tubulin depolymerization in human Jurkat cells at 5 to 20 uM after 4 hrs by Western blot method |
27689728 |
HCT116 |
Function assay |
10 uM |
1 hr |
Induction of reactive oxygen species generation in human HCT116 cells at 10 uM after 1 hr by DCFH-DA dye-based fluorescence microscopic analysis |
28434764 |
HCT116 |
Cell cycle assay |
1 to 5 uM |
24 hrs |
Cell cycle arrest in human HCT116 cells assessed as accumulation at S phase 1 to 5 uM after 24 hrs by propidium iodide staining based flow cytometric method |
28434764 |
HCT116 |
Cell cycle assay |
1 to 5 uM |
24 hrs |
Cell cycle arrest in human HCT116 cells assessed as accumulation at G0/G1 phase at 1 to 5 uM after 24 hrs by propidium iodide staining based flow cytometric method |
28434764 |
HCT116 |
Cell cycle assay |
1 to 5 uM |
24 hrs |
Cell cycle arrest in human HCT116 cells decrease in population at G0/G1 phase at 1 to 5 uM after 24 hrs by propidium iodide staining based flow cytometric method |
28434764 |
HCT116 |
Antiproliferative assay |
10 uM |
72 hrs |
Antiproliferative activity against human HCT116 cells at 10 uM after 72 hrs by MTT assay |
28686911 |
A549 |
Antiproliferative assay |
10 uM |
72 hrs |
Antiproliferative activity against human A549 cells at 10 uM after 72 hrs by MTT assay |
28686911 |
K562 |
Antiproliferative assay |
10 uM |
72 hrs |
Antiproliferative activity against human K562 cells at 10 uM after 72 hrs by MTT assay |
28686911 |
HCT116 |
Antimigratory assay |
50 nM |
48 hrs |
Antimigratory activity in human HCT116 cells assessed as inhibition of TGF-beta1-induced cell migration at 50 nM after 48 hrs by trans-well assay |
29424539 |
HCT116 |
Function assay |
10 uM |
3 hrs |
Induction of ROS accumulation in human HCT116 cells at 10 uM after 3 hrs by DCFH-DA staining-based fluorescence microscopic analysis |
29424539 |
HCT116 |
Antiproliferative assay |
8 uM |
72 hrs |
Antiproliferative activity against human HCT116 cells at 8 uM after 72 hrs by MTT assay |
29424539 |
HCT116 |
Antiinvasive assay |
50 nM |
48 hrs |
Antiinvasive activity in human HCT116 cells assessed as inhibition of TGF-beta1-induced cell invasion at 50 nM after 48 hrs by crystal violet staining-based assay |
29424539 |
HCT116 |
Function assay |
50 nM |
1 hr |
Inhibition of IL-1beta-mediated adhesion of human rhodamine 123-labeled HCT116 cells to HUVEC at 50 nM after 1 hr by fluoresence assay |
29424539 |
HCT116 |
Function assay |
50 nM |
48 hrs |
Inhibition of TGF-beta1-induced decrease in expression levels of E-cadherin protein in human HCT116 cells at 50 nM after 48 hrs by Western blot analysis |
29424539 |
HCT116 |
Function assay |
50 nM |
48 hrs |
Inhibition of TGF-beta1-induced increase in expression levels of vimentin protein in human HCT116 cells at 50 nM after 48 hrs by Western blot analysis |
29424539 |
HCT116 |
Function assay |
50 nM |
48 hrs |
Inhibition of TGF-beta1-induced increase in expression levels of MMP-9 protein in human HCT116 cells at 50 nM after 48 hrs by Western blot analysis |
29424539 |
HCT116 |
Function assay |
50 nM |
48 hrs |
Inhibition of TGF-beta1-induced increase in expression levels of snail protein in human HCT116 cells at 50 nM after 48 hrs by Western blot analysis |
29424539 |
HCT116 |
Function assay |
50 nM |
48 hrs |
Inhibition of TGF-beta1-induced increase in expression levels of twist protein in human HCT116 cells at 50 nM after 48 hrs by Western blot analysis |
29424539 |
HCT116 |
Function assay |
50 nM |
48 hrs |
Inhibition of TGF-beta1-induced AKT phosphorylation in human HCT116 cells at 50 nM after 48 hrs by Western blot analysis |
29424539 |
HCT116 |
Function assay |
50 nM |
48 hrs |
Inhibition of TGF-beta1-induced GSK-3beta phosphorylation in human HCT116 cells at 50 nM after 48 hrs by Western blot analysis |
29424539 |
HCT116 |
Function assay |
50 nM |
48 hrs |
Inhibition of TGF-beta1-regulated decrease in cytoplasmic beta-catenin in human HCT116 cells at 50 nM after 48 hrs by Western blot analysis |
29424539 |
HCT116 |
Function assay |
50 nM |
48 hrs |
Inhibition of TGF-beta1-regulated increase in nuclear beta-catenin in human HCT116 cells at 50 nM after 48 hrs by Western blot analysis |
29424539 |
WI38 |
Function assay |
5 uM |
24 hrs |
Induction of OXR1 degradation in ionizing radiation induced human WI38 senescent cells at 5 uM after 24 hrs by Western blot analysis |
29925484 |
WI38 |
Function assay |
up to 64 uM |
1.5 hrs |
Induction of ROS production in ionizing radiation induced human WI38 senescent cells up to 64 uM after 1.5 hrs by DHR123 dye based flow cytometry |
29925484 |
RAW264.7 |
Function assay |
10 uM |
0.5 hrs |
Inhibition of MAPK/NFkappaB in ICR mouse RAW264.7 cells assessed as reduction in LPS-induced TNFalpha production at 10 uM pretreated for 0.5 hrs followed by LPS challenge and measured after 24 hrs by ELISA relative to control |
30780088 |
RAW264.7 |
Function assay |
10 uM |
0.5 hrs |
Inhibition of MAPK/NFkappaB in ICR mouse RAW264.7 cells assessed as reduction in LPS-induced IL6 production at 10 uM pretreated for 0.5 hrs followed by LPS challenge and measured after 24 hrs by ELISA relative to control |
30780088 |
HaCaT |
Cytotoxicity assay |
|
24 hrs |
Cytotoxicity against human HaCaT cells assessed as reduction in cell viability after 24 hrs by MTT reduction assay, IC50=16μM |
25305718 |
PANC1 |
Cytotoxicity assay |
|
24 hrs |
Cytotoxicity against human PANC1 cells assessed as reduction in cell viability after 24 hrs by MTT reduction assay, IC50=3.2μM |
25305718 |
MRC5 |
Cytotoxicity assay |
|
72 hrs |
Cytotoxicity against human MRC5 cells after 72 hrs by MTT assay, IC50=35.04μM |
24937186 |
WI38 |
Cytotoxicity assay |
|
72 hrs |
Cytotoxicity against human WI38 cells after 72 hrs by MTT assay, IC50=26.78μM |
24937186 |
A549 |
Cytotoxicity assay |
|
72 hrs |
Cytotoxicity against human A549 cells after 72 hrs by MTT assay, IC50=22.85μM |
24937186 |
MDA-MB-231 |
Cytotoxicity assay |
|
72 hrs |
Cytotoxicity against human MDA-MB-231 cells after 72 hrs by MTT assay, IC50=8.46μM |
24937186 |
HCT116 |
Cytotoxicity assay |
|
72 hrs |
Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay, IC50=6.04μM |
24937186 |
ZR75-30 |
Cytotoxicity assay |
|
72 hrs |
Cytotoxicity against human ZR75-30 cells after 72 hrs by MTT assay, IC50=5.86μM |
24937186 |
MA9.3 |
Cytotoxicity assay |
|
48 hrs |
Cytotoxicity against human MA9.3 cells after 48 hrs by MTT assay, IC50=2μM |
25464887 |
SK-MEL-2 |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human SK-MEL-2 cells after 72 hrs by MTT assay, EC50=4.39μM |
25826398 |
HaCaT |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human HaCaT cells after 72 hrs by MTT assay, EC50=4.46μM |
25826398 |
A375 |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human A375 cells after 72 hrs by MTT assay, EC50=6.17μM |
25826398 |
HCT116 |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay, EC50=11.5μM |
25826398 |
A549 |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human A549 cells after 72 hrs by MTT assay, EC50=12.2μM |
25826398 |
HFF1 |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against HFF1 cells after 72 hrs by MTT assay, EC50=13.1μM |
25826398 |
MCF10A |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human MCF10A cells after 72 hrs by MTT assay, EC50=18.1μM |
25826398 |
A549 |
Function assay |
|
3 hrs |
Induction of ROS production in human A549 cells after 3 hrs by DHE staining-based fluorescence assay |
25826398 |
A549 |
Function assay |
|
3 hrs |
Induction of ROS production in human A549 cells after 3 hrs by APF staining-based fluorescence assay |
25826398 |
HT1080 |
Cytotoxicity assay |
|
72 hrs |
Cytotoxicity against human HT1080 cells assessed as cell viability after 72 hrs by resazurin reduction assay, IC50=3.43μM |
26599530 |
GBM10 |
Cytotoxicity assay |
|
72 hrs |
Cytotoxicity against human GBM10 cells assessed as cell viability after 72 hrs by resazurin reduction assay, IC50=3.81μM |
26599530 |
SF188 |
Cytotoxicity assay |
|
72 hrs |
Cytotoxicity against human SF188 cells assessed as cell viability after 72 hrs by resazurin reduction assay, IC50=3.9μM |
26599530 |
SKBR3 |
Cytotoxicity assay |
|
72 hrs |
Cytotoxicity against human SKBR3 cells assessed as cell viability after 72 hrs by resazurin reduction assay, IC50=4.04μM |
26599530 |
T98G |
Cytotoxicity assay |
|
72 hrs |
Cytotoxicity against human T98G cells assessed as cell viability after 72 hrs by resazurin reduction assay, IC50=4.92μM |
26599530 |
HT-29 |
Cytotoxicity assay |
|
72 hrs |
Cytotoxicity against human HT-29 cells assessed as cell viability after 72 hrs by resazurin reduction assay, IC50=5.49μM |
26599530 |
MCF7 |
Cytotoxicity assay |
|
72 hrs |
Cytotoxicity against human MCF7 cells assessed as cell viability after 72 hrs by resazurin reduction assay, IC50=6.14μM |
26599530 |
A549 |
Cytotoxicity assay |
|
72 hrs |
Cytotoxicity against human A549 cells assessed as cell viability after 72 hrs by resazurin reduction assay, IC50=6.54μM |
26599530 |
MV4-11 |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human MV4-11 cells after 72 hrs in presence of SAHA by MTT assay, IC50=0.2891μM |
27505848 |
CMK |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against Ara-C resistant human CMK cells after 72 hrs in presence of SAHA by MTT assay, IC50=0.4218μM |
27505848 |
CMY |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human CMY cells after 72 hrs in presence of SAHA by MTT assay, IC50=0.4424μM |
27505848 |
HL60 |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human HL60 cells after 72 hrs in presence of SAHA by MTT assay, IC50=0.5292μM |
27505848 |
CMK |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human CMK cells after 72 hrs in presence of SAHA by MTT assay, IC50=0.6127μM |
27505848 |
U937 |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against p53 null human U937 cells after 72 hrs in presence of SAHA by MTT assay, IC50=0.767μM |
27505848 |
MOLM13 |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human MOLM13 cells harboring wild type p53/FLT3-ITD mutant after 72 hrs in presence of SAHA by MTT assay, IC50=0.9345μM |
27505848 |
CMS |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human CMS cells after 72 hrs in presence of SAHA by MTT assay, IC50=1.037μM |
27505848 |
OCI-AML3 |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human OCI-AML3 cells after 72 hrs in presence of SAHA by MTT assay, IC50=1.109μM |
27505848 |
HL60 |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against Ara-C resistant human HL60 cells after 72 hrs in presence of SAHA by MTT assay, IC50=1.128μM |
27505848 |
MV4-11 |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human MV4-11 cells after 72 hrs by MTT assay, IC50=1.439μM |
27505848 |
CMY |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human CMY cells after 72 hrs by MTT assay, IC50=1.62μM |
27505848 |
HL60 |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human HL60 cells after 72 hrs by MTT assay, IC50=1.778μM |
27505848 |
MOLM13 |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human MOLM13 cells harboring wild type p53/FLT3-ITD mutant after 72 hrs by MTT assay, IC50=1.838μM |
27505848 |
OCI-AML3 |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human OCI-AML3 cells after 72 hrs by MTT assay, IC50=1.868μM |
27505848 |
CMK |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against Ara-C resistant human CMK cells after 72 hrs by MTT assay, IC50=1.911μM |
27505848 |
U937 |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against p53 null human U937 cells after 72 hrs by MTT assay, IC50=2.174μM |
27505848 |
HL60 |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against Ara-C resistant human HL60 cells after 72 hrs by MTT assay, IC50=2.25μM |
27505848 |
CMK |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human CMK cells after 72 hrs by MTT assay, IC50=2.815μM |
27505848 |
CMS |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human CMS cells after 72 hrs by MTT assay, IC50=3.097μM |
27505848 |
MCF7 |
Antiproliferative assay |
|
48 hrs |
Antiproliferative activity in human MCF7 cells assessed as cell viability after 48 hrs by alamarBlue assay, IC50=1.2μM |
27689728 |
Jurkat |
Antiproliferative assay |
|
48 hrs |
Antiproliferative activity in human Jurkat cells assessed as cell viability after 48 hrs by alamarBlue assay, IC50=1.4μM |
27689728 |
Jurkat |
Cytotoxicity assay |
|
24 hrs |
Cytotoxicity against human Jurkat cells after 24 hrs by MTT assay, IC50=5μM |
27689728 |
MCF7 |
Cytotoxicity assay |
|
24 hrs |
Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay, IC50=8μM |
27689728 |
A549 |
Function assay |
|
24 hrs |
Inhibition of NF-kappaB in human A549 cells after 24 hrs by luciferase reporter gene assay, IC50=1.76μM |
27810594 |
HepG2 |
Cytotoxicity assay |
|
72 hrs |
Cytotoxicity against human HepG2 cells assessed as growth inhibition after 72 hrs by MTT assay, IC50=8.9μM |
28159415 |
HCT116 |
Cytotoxicity assay |
|
72 hrs |
Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by MTT assay, IC50=9.2μM |
28159415 |
A549 |
Cytotoxicity assay |
|
72 hrs |
Cytotoxicity against human A549 cells assessed as growth inhibition after 72 hrs by MTT assay, IC50=10μM |
28159415 |
MRC5 |
Cytotoxicity assay |
|
72 hrs |
Cytotoxicity against human MRC5 cells after 72 hrs by MTT assay, IC50=37μM |
28159415 |
A549 |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human A549 cells after 72 hrs by MTT assay, IC50=6.84μM |
28434764 |
Saos2 |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human Saos2 cells after 72 hrs by MTT assay, IC50=7.31μM |
28434764 |
HCT116 |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay, IC50=7.34μM |
28434764 |
U2OS |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human U2OS cells after 72 hrs by MTT assay, IC50=9.49μM |
28434764 |
MDA-MB-231 |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay, IC50=10.6μM |
28434764 |
SKHEP1 |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human SKHEP1 cells after 72 hrs by MTT assay, IC50=13.3μM |
28434764 |
HT-29 |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human HT-29 cells after 72 hrs by MTT assay, IC50=2.65μM |
28686911 |
HCT8 |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human HCT8 cells after 72 hrs by MTT assay, IC50=4.1μM |
28686911 |
HCT116 |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay, IC50=8.13μM |
28686911 |
CCD-841 |
Cytotoxicity assay |
|
72 hrs |
Cytotoxicity against human CCD-841 cells assessed as reduction in cell viability after 72 hrs by MTT assay, IC50=44.32μM |
28686911 |
HT-29 |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human HT-29 cells after 72 hrs by MTT assay, IC50=2.65μM |
29424539 |
HCT8 |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human HCT8 cells after 72 hrs by MTT assay, IC50=4.1μM |
29424539 |
SW620 |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human SW620 cells after 72 hrs by MTT assay, IC50=4.62μM |
29424539 |
K562 |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human K562 cells after 72 hrs by MTT assay, IC50=5.05μM |
29424539 |
K562 |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human K562 cells after 72 hrs in presence of ligustrazine by MTT assay, IC50=5.09μM |
29424539 |
HCT116 |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay, IC50=8.13μM |
29424539 |
HCT116 |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human HCT116 cells after 72 hrs in presence of ligustrazine by MTT assay, IC50=8.17μM |
29424539 |
A549 |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human A549 cells after 72 hrs in presence of ligustrazine by MTT assay, IC50=15.22μM |
29424539 |
A549 |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human A549 cells after 72 hrs by MTT assay, IC50=15.28μM |
29424539 |
U87MG |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human U87MG cells after 72 hrs in presence of ligustrazine by MTT assay, IC50=16.15μM |
29424539 |
U87MG |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human U87MG cells after 72 hrs by MTT assay, IC50=17.34μM |
29424539 |
CCD-841 |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human CCD-841 cells after 72 hrs by MTT assay, IC50=44.32μM |
29424539 |
DU145 |
Function assay |
|
24 hrs |
Inhibition of STAT3 phosphorylation at Tyr705 residues in human DU145 cells after 24 hrs by Western blot analysis, IC50=7μM |
29807795 |
DU145 |
Growth inhibition assay |
|
48 hrs |
Growth inhibition of human DU145 cells after 48 hrs by WST-1 assay, GI50=7.1μM |
29807795 |
LNCAP |
Growth inhibition assay |
|
48 hrs |
Growth inhibition of human LNCAP cells after 48 hrs by WST-1 assay, GI50=9.2μM |
29807795 |
BHK21 |
Cytotoxicity assay |
|
48 hrs |
Cytotoxicity against BHK21 cells assessed as reduction in cell viability after 48 hrs by MTT assay, CC50=40.14μM |
31009908 |
SH-SY5Y |
Cytotoxicity assay |
|
72 hrs |
Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay, IC50=5.94μM |
31400708 |
U87 |
Cytotoxicity assay |
|
72 hrs |
Cytotoxicity against human U87 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay, IC50=7.18μM |
31400708 |
SH-SY5Y |
Function assay |
|
15 mins |
Inhibition of TrxR in human SH-SY5Y cells using DTNB as substrate preincubated for 15 mins followed by substrate addition and measured for 20 mins by Ellman's method, IC50=45.88μM |
31400708 |
RAW264.7 |
Antiinflammatory assay |
|
|
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production, IC50=3μM |
25453809 |
WI38 |
Function assay |
|
|
Senolytic activity against ionizing radiation induced human WI38 senescent cells assessed as reduction in cell viability by propidium iodide staining based flow cytometry, EC50=8μM |
29925484 |
WI38 |
Function assay |
|
|
Senolytic activity against non-senescent human WI38 cells assessed as reduction in cell viability by propidium iodide staining based flow cytometry, EC50=20.3μM |
29925484 |