MAO

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MAO製品

All (35)
MAO阻害剤 (35)
新製品

製品コード	製品名称	製品説明	文献中Selleckの製品使用例
S2302	Glycyrrhizin (NSC 167409)	Glycyrrhizin (NSC 167409, Glycyrrhizic Acid) is a direct HMGB1(high mobility group box 1) inhibitor that inhibits HMGB1-dependent inflammatory molecule expression and oxidative stress; modulates P38 and P-JNK but not p-ERK signalling; Also inhibits 11 beta-hydroxysteroid dehydrogenase and monoamine oxidase (MAO).	Ecotoxicol Environ Saf, 2024, 272:116068 Front Immunol, 2023, 14:1024706 Front Immunol, 2023, 10.3389/fimmu.2023.1024706
S4246	Tranylcypromine HCl	Tranylcypromine HCl is a monoamine oxidase inhibitor, which inhibits CYP2A6 with K_i of 0.08 μM and 0.2 μM in cDNA-expressing microsomes and Human Liver Microsomes, respectively.	Cell Rep, 2023, 42(6):112566 Biomolecules, 2023, 13(3)521 Biomolecules, 2023, 13(3)521
S9464	Tranylcypromine Sulfate	Tranylcypromine Sulfate is an irreversible inhibitor of monoamine oxidase (MAO) with a rapid onset of activity.	Int J Mol Sci, 2022, 23(8)4213 Nan Fang Yi Ke Da Xue Xue Bao, 2021, 41(3):418-423 Nat Methods, 2020, 17(5):495-503
S3212	Moclobemide (Ro 111163)	Moclobemide is a MAO-A (5-HT) inhibitor with IC50 of 6.1 μM.	J Gerontol A Biol Sci Med Sci, 2022, 77-8:1485-1493 Biol Reprod, 2021, ioab182 Pharmacol Biochem Behav, 2018, 166:13-20
S2102	Rasagiline Mesylate	Rasagiline Mesylate (TVP-1012,(R)-AGN1135 mesylate,TVP1012 mesylate) is a new MAO-B inhibitor for the treatment of idiopathic Parkinson's disease.	Front Pharmacol, 2022, 13:1004215 EMBO Mol Med, 2021, e13929
S4033	Sennoside A	Sennoside A (NSC 112929), a kind of irritant laxative isolated from rhei rhizome, causes purgative actions in the intestine.	Sci Adv, 2022, 8(15):eabm3471 Front Pharmacol, 2020, 11:566099
S3690	Pargyline hydrochloride	Pargyline is an irreversible inhibitor of monoamine oxidase (MAO)-B with Ki values of 13 and 0.5 μM for time-dependent inhibition of the activity of MAO-A and -B, respectivey.	Genome Med, 2021, 13(1):168 Cancer Lett, 2017, 398:12-21
S2339	Paeonol	Paeonol (Peonol), a phenolic compound extracted from Chinese herbs Paeonia suffruticosa (moutan cortex) and Cynanchum paniculatum, inhibits MAO with an IC50 of about 50 μM.	Biochem Biophys Res Commun, 2023, 656:86-96 Int J Biol Sci, 2019, 15(11):2497-2508
S3868	Harmine	Harmine (Telepathine), a fluorescent harmala alkaloid belonging to the beta-carboline family of compounds, is a highly cell-permeant and competitive inhibitor of ATP binding to the kinase pocket of DYRK1A, with about 60-fold higher IC50 value for DYRK2. Harmine also inhibits monoamine oxidases (MAOs), PPARγ and cdc-like kinases (CLKs). Harmine inhibits 5-HT2A serotonin receptor with Ki of 397 nM.	J Gerontol A Biol Sci Med Sci, 2022, 77-8:1485-1493 Cell Death Dis, 2019, 10(12):899
S5269	J147	J147, a curcumin derivative, is a potent neurogenic and neuroprotective compound developed for the treatment of neurodegenerative conditions associated with aging.	J Mol Histol, 2023, 54(6):725-738.
S3817	Harmine hydrochloride	Harmine (Telepathine), a fluorescent harmala alkaloid belonging to the beta-carboline family of compounds, is a highly cell-permeant and competitive inhibitor of ATP binding to the kinase pocket of DYRK1A, with about 60-fold higher IC50 value for DYRK2. Harmine also inhibits monoamine oxidases (MAOs), PPARγ and cdc-like kinases (CLKs). Harmine inhibits 5-HT2A serotonin receptor with Ki of 397 nM.	Cancers (Basel), 2022, 14(2)326
S5795	Rasagiline	Rasagiline (TVP-1012) is a novel selective and irreversible MAO-B propargylamine inhibitor with in vitro IC50s of 4.43 nM and 412 nM for MAO-B and MAO-A, respectively.	EMBO Mol Med, 2021, e13929
S4717	Isatin	Isatin (2,3-Indolinedione) is an endogenous MAO inhibitor and more active against MAO-B than MAO-A	Cell Rep, 2022, 38(13):110559
S1472	Safinamide Mesylate	Safinamide Mesylate (PNU-151774E, FCE28073) is mesylate salt of Safinamide, selectively and reversibly inhibits MAO-B with IC50 of 98 nM, exhibits 5918-fold selectivity against MAO-A. Phase 3.
S4856	Iproniazid	Iproniazid (Marsilid, Iprazid) is a non-selective, irreversible monoamine oxidase (MAO) inhibitor (MAOI) that is used as an antidepressive agent.
S5357	Safinamide	Safinamide (EMD-1195686, PNU-15774E) is an orally active, selective, reversible monoamine oxidase-B inhibitor with both dopaminergic and non-dopaminergic (glutamatergic) properties. The IC50 value of safinamide for MAO-B is 98 nM.
E2632	Norharmane	Norharmane (Norharman) is a potent and selective monoamine oxidase A (MAO-A) inhibitor with a Ki of 3.34 μM.
S3273	Hypericin	Hypericin (Hyp, HY) is a naturally occurring substance found in the common St. John's Wort (Hypericum species) with antidepressive, antineoplastic and antiviral (human immunodeficiency and hepatitis C virus) activities. Hypericin has inhibitory effects on MAO (monoaminoxidase), PKC (protein kinase C), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450).	Eur J Pharmacol, 2021, 900:174071
S9894^New	Vafidemstat	Vafidemstat(ORY-2001) is a potent, selective, brain-penetrant dual inhibitor of lysine-specific histone demethylase (LSD1, KDM1A) and MAO-B, with IC50 values of 105 nM and 58 nM, respectively. It shows potential for treating memory deficits and behavioral alterations in neurodegenerative and psychiatric diseases.
S3291	Myristicin	Myristicin (Myristicine), a terpene-like active component in Nutmeg which is the seed of Myristica fragrans, is a weak inhibitor of monamine oxidase (MAO) and a mechanism-based inhibitor of CYP1A2.
E4823^New	Pargyline	Pargyline is an irreversible selective inhibitor of monoamine oxidase (MAO) with Kis of 13 μM and 0.5 μM for MAO-A and MAO-B respectively. It has pharmaceutical potential as an anticancer drug for human prostate cancer.
S6602	TB5	TB5 is a potent and selective MAO-B inhibitor with Ki values of 110 and 1,450 nM for MAO-B and MAO-A, respectively.
S5663	Minaprine dihydrochloride	Minaprine dihydrochloride is hydrochloride salt form of Minaprine, which acts as a reversible inhibitor of MAO-A in rats and weakly inhibit acetylcholinesterase in rat brain (striatum) homogenates.
E0165	Phenelzine sulfate	Phenelzine Sulfate is a hydrazine derivative and acts as a potent non-selective monoamine oxidase (MAO) inhibitor with an IC50 of 0.9 μM.
E0009	Harmane	Harmane (Harman, Aribine, Aribin, Locuturine, Locuturin, Loturine, Passiflorin, 1-Methylnorharman, NSC 54439) is a common compound in several foods, plants and beverages. Harmane is a selective monoamine oxidase inhibitors with IC50s of 0.5 μM and 5 μM for human MAO A and MAO B, respectively. Harmane also inhibits the apurinic/apyrimidinic (AP) endonuclease activity of the UV endonuclease induced by phage T4.
S9463^New	Demecarium Bromide	Demecarium Bromide, an anticholinesterase, is an inhibitor of monoamine oxidase (MAO). It induces long-term miosis and decreases intraocular pressure (IOP) in normotensive eyes of Beagles and of eyes of Beagles with inherited glaucoma.
E4805^New	Methylene Blue trihydrate	Methylene blue trihydrate (C.I. Basic Blue 9 trihydrate) acts as an inhibitor of soluble guanylyl cyclase (sGC), monoamine oxidase A (MAO-A) and NO synthase (NOS). Methylene blue trihydrate exhibits antimalarial, antidepressant, and anxiolytic activity effects. Methylene Blue trihydrate has potential applications in treating methemoglobinemia, neurodegenerative disorders, and ifosfamide-induced encephalopathy.
S6422	Lazabemide	Lazabemide (Ro 19-6327) is a reversible and selective inhibitor of monoamine oxidase B (MAO-B) with Ki value of 7.9 nM.
S0160	Toloxatone (MD69276)	Toloxatone (MD69276, Humoryl, Perenum, Umoril) is a reversible inhibitor of monoamine oxidase A (MAO-A) with IC50 of  0.93 µM. Toloxatone is an antidepressant agent.
E2226	4-Hydroxyderricin	4-Hydroxyderricin(4-HD), the major active ingredients of Angelica keiskei Koidzumi, is a potent selective monoamine oxidase (MAO) inhibitor with mild inhibitory effect on dopamine β-hydroxylase.
S6462	Amezinium (methylsulfate)	Amezinium is a sympathomimetic used for its vasopressor effects in the treatment of hypotensive states. It is a MAO inhibitor, antagonizes the response to tyramine and blocks neuronal uptake of noradrenaline.
E2231	Xanthoangelol	Xanthoangelol, a chalcone found in the roots of Angelica keiskei, is a nonselective monoamine oxidase (MAO) inhibitor and a potent dopamine β-hydroxylase (DBH) inhibitor. It has anti-inflammatory, antibiotic and pro-apoptotic activities.
S2419	Eprobemide	Eprobemide (Befol, LIS 630) is a reversible monoamine oxidase A (MAO-A) inhibitor. Eprobemide acts as an antidepressant in Russia.
S4483	Iproniazid phosphate	Iproniazid (Marsilid, Iprazid) phosphate is a non-selective, irreversible monoamine oxidase (MAO) inhibitor (MAOI) that is used as an antidepressive agent.
E0784	MAO-B-IN-2	MAO-B-IN-2 is a selective and competitive inhibitor of MAO-B and BChE with IC50 values of 0.51 and 7.00 μM, respectively.
S2302	Glycyrrhizin (NSC 167409)	Glycyrrhizin (NSC 167409, Glycyrrhizic Acid) is a direct HMGB1(high mobility group box 1) inhibitor that inhibits HMGB1-dependent inflammatory molecule expression and oxidative stress; modulates P38 and P-JNK but not p-ERK signalling; Also inhibits 11 beta-hydroxysteroid dehydrogenase and monoamine oxidase (MAO).	Ecotoxicol Environ Saf, 2024, 272:116068 Front Immunol, 2023, 14:1024706 Front Immunol, 2023, 10.3389/fimmu.2023.1024706
S4246	Tranylcypromine HCl	Tranylcypromine HCl is a monoamine oxidase inhibitor, which inhibits CYP2A6 with K_i of 0.08 μM and 0.2 μM in cDNA-expressing microsomes and Human Liver Microsomes, respectively.	Cell Rep, 2023, 42(6):112566 Biomolecules, 2023, 13(3)521 Biomolecules, 2023, 13(3)521
S9464	Tranylcypromine Sulfate	Tranylcypromine Sulfate is an irreversible inhibitor of monoamine oxidase (MAO) with a rapid onset of activity.	Int J Mol Sci, 2022, 23(8)4213 Nan Fang Yi Ke Da Xue Xue Bao, 2021, 41(3):418-423 Nat Methods, 2020, 17(5):495-503
S3212	Moclobemide (Ro 111163)	Moclobemide is a MAO-A (5-HT) inhibitor with IC50 of 6.1 μM.	J Gerontol A Biol Sci Med Sci, 2022, 77-8:1485-1493 Biol Reprod, 2021, ioab182 Pharmacol Biochem Behav, 2018, 166:13-20
S2102	Rasagiline Mesylate	Rasagiline Mesylate (TVP-1012,(R)-AGN1135 mesylate,TVP1012 mesylate) is a new MAO-B inhibitor for the treatment of idiopathic Parkinson's disease.	Front Pharmacol, 2022, 13:1004215 EMBO Mol Med, 2021, e13929
S4033	Sennoside A	Sennoside A (NSC 112929), a kind of irritant laxative isolated from rhei rhizome, causes purgative actions in the intestine.	Sci Adv, 2022, 8(15):eabm3471 Front Pharmacol, 2020, 11:566099
S3690	Pargyline hydrochloride	Pargyline is an irreversible inhibitor of monoamine oxidase (MAO)-B with Ki values of 13 and 0.5 μM for time-dependent inhibition of the activity of MAO-A and -B, respectivey.	Genome Med, 2021, 13(1):168 Cancer Lett, 2017, 398:12-21
S2339	Paeonol	Paeonol (Peonol), a phenolic compound extracted from Chinese herbs Paeonia suffruticosa (moutan cortex) and Cynanchum paniculatum, inhibits MAO with an IC50 of about 50 μM.	Biochem Biophys Res Commun, 2023, 656:86-96 Int J Biol Sci, 2019, 15(11):2497-2508
S3868	Harmine	Harmine (Telepathine), a fluorescent harmala alkaloid belonging to the beta-carboline family of compounds, is a highly cell-permeant and competitive inhibitor of ATP binding to the kinase pocket of DYRK1A, with about 60-fold higher IC50 value for DYRK2. Harmine also inhibits monoamine oxidases (MAOs), PPARγ and cdc-like kinases (CLKs). Harmine inhibits 5-HT2A serotonin receptor with Ki of 397 nM.	J Gerontol A Biol Sci Med Sci, 2022, 77-8:1485-1493 Cell Death Dis, 2019, 10(12):899
S5269	J147	J147, a curcumin derivative, is a potent neurogenic and neuroprotective compound developed for the treatment of neurodegenerative conditions associated with aging.	J Mol Histol, 2023, 54(6):725-738.
S3817	Harmine hydrochloride	Harmine (Telepathine), a fluorescent harmala alkaloid belonging to the beta-carboline family of compounds, is a highly cell-permeant and competitive inhibitor of ATP binding to the kinase pocket of DYRK1A, with about 60-fold higher IC50 value for DYRK2. Harmine also inhibits monoamine oxidases (MAOs), PPARγ and cdc-like kinases (CLKs). Harmine inhibits 5-HT2A serotonin receptor with Ki of 397 nM.	Cancers (Basel), 2022, 14(2)326
S5795	Rasagiline	Rasagiline (TVP-1012) is a novel selective and irreversible MAO-B propargylamine inhibitor with in vitro IC50s of 4.43 nM and 412 nM for MAO-B and MAO-A, respectively.	EMBO Mol Med, 2021, e13929
S4717	Isatin	Isatin (2,3-Indolinedione) is an endogenous MAO inhibitor and more active against MAO-B than MAO-A	Cell Rep, 2022, 38(13):110559
S1472	Safinamide Mesylate	Safinamide Mesylate (PNU-151774E, FCE28073) is mesylate salt of Safinamide, selectively and reversibly inhibits MAO-B with IC50 of 98 nM, exhibits 5918-fold selectivity against MAO-A. Phase 3.
S4856	Iproniazid	Iproniazid (Marsilid, Iprazid) is a non-selective, irreversible monoamine oxidase (MAO) inhibitor (MAOI) that is used as an antidepressive agent.
S5357	Safinamide	Safinamide (EMD-1195686, PNU-15774E) is an orally active, selective, reversible monoamine oxidase-B inhibitor with both dopaminergic and non-dopaminergic (glutamatergic) properties. The IC50 value of safinamide for MAO-B is 98 nM.
E2632	Norharmane	Norharmane (Norharman) is a potent and selective monoamine oxidase A (MAO-A) inhibitor with a Ki of 3.34 μM.
S3273	Hypericin	Hypericin (Hyp, HY) is a naturally occurring substance found in the common St. John's Wort (Hypericum species) with antidepressive, antineoplastic and antiviral (human immunodeficiency and hepatitis C virus) activities. Hypericin has inhibitory effects on MAO (monoaminoxidase), PKC (protein kinase C), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450).	Eur J Pharmacol, 2021, 900:174071
S9894^New	Vafidemstat	Vafidemstat(ORY-2001) is a potent, selective, brain-penetrant dual inhibitor of lysine-specific histone demethylase (LSD1, KDM1A) and MAO-B, with IC50 values of 105 nM and 58 nM, respectively. It shows potential for treating memory deficits and behavioral alterations in neurodegenerative and psychiatric diseases.
S3291	Myristicin	Myristicin (Myristicine), a terpene-like active component in Nutmeg which is the seed of Myristica fragrans, is a weak inhibitor of monamine oxidase (MAO) and a mechanism-based inhibitor of CYP1A2.
E4823^New	Pargyline	Pargyline is an irreversible selective inhibitor of monoamine oxidase (MAO) with Kis of 13 μM and 0.5 μM for MAO-A and MAO-B respectively. It has pharmaceutical potential as an anticancer drug for human prostate cancer.
S6602	TB5	TB5 is a potent and selective MAO-B inhibitor with Ki values of 110 and 1,450 nM for MAO-B and MAO-A, respectively.
S5663	Minaprine dihydrochloride	Minaprine dihydrochloride is hydrochloride salt form of Minaprine, which acts as a reversible inhibitor of MAO-A in rats and weakly inhibit acetylcholinesterase in rat brain (striatum) homogenates.
E0165	Phenelzine sulfate	Phenelzine Sulfate is a hydrazine derivative and acts as a potent non-selective monoamine oxidase (MAO) inhibitor with an IC50 of 0.9 μM.
E0009	Harmane	Harmane (Harman, Aribine, Aribin, Locuturine, Locuturin, Loturine, Passiflorin, 1-Methylnorharman, NSC 54439) is a common compound in several foods, plants and beverages. Harmane is a selective monoamine oxidase inhibitors with IC50s of 0.5 μM and 5 μM for human MAO A and MAO B, respectively. Harmane also inhibits the apurinic/apyrimidinic (AP) endonuclease activity of the UV endonuclease induced by phage T4.
S9463^New	Demecarium Bromide	Demecarium Bromide, an anticholinesterase, is an inhibitor of monoamine oxidase (MAO). It induces long-term miosis and decreases intraocular pressure (IOP) in normotensive eyes of Beagles and of eyes of Beagles with inherited glaucoma.
E4805^New	Methylene Blue trihydrate	Methylene blue trihydrate (C.I. Basic Blue 9 trihydrate) acts as an inhibitor of soluble guanylyl cyclase (sGC), monoamine oxidase A (MAO-A) and NO synthase (NOS). Methylene blue trihydrate exhibits antimalarial, antidepressant, and anxiolytic activity effects. Methylene Blue trihydrate has potential applications in treating methemoglobinemia, neurodegenerative disorders, and ifosfamide-induced encephalopathy.
S6422	Lazabemide	Lazabemide (Ro 19-6327) is a reversible and selective inhibitor of monoamine oxidase B (MAO-B) with Ki value of 7.9 nM.
S0160	Toloxatone (MD69276)	Toloxatone (MD69276, Humoryl, Perenum, Umoril) is a reversible inhibitor of monoamine oxidase A (MAO-A) with IC50 of  0.93 µM. Toloxatone is an antidepressant agent.
E2226	4-Hydroxyderricin	4-Hydroxyderricin(4-HD), the major active ingredients of Angelica keiskei Koidzumi, is a potent selective monoamine oxidase (MAO) inhibitor with mild inhibitory effect on dopamine β-hydroxylase.
S6462	Amezinium (methylsulfate)	Amezinium is a sympathomimetic used for its vasopressor effects in the treatment of hypotensive states. It is a MAO inhibitor, antagonizes the response to tyramine and blocks neuronal uptake of noradrenaline.
E2231	Xanthoangelol	Xanthoangelol, a chalcone found in the roots of Angelica keiskei, is a nonselective monoamine oxidase (MAO) inhibitor and a potent dopamine β-hydroxylase (DBH) inhibitor. It has anti-inflammatory, antibiotic and pro-apoptotic activities.
S2419	Eprobemide	Eprobemide (Befol, LIS 630) is a reversible monoamine oxidase A (MAO-A) inhibitor. Eprobemide acts as an antidepressant in Russia.
S4483	Iproniazid phosphate	Iproniazid (Marsilid, Iprazid) phosphate is a non-selective, irreversible monoamine oxidase (MAO) inhibitor (MAOI) that is used as an antidepressive agent.
E0784	MAO-B-IN-2	MAO-B-IN-2 is a selective and competitive inhibitor of MAO-B and BChE with IC50 values of 0.51 and 7.00 μM, respectively.
S9894^New	Vafidemstat	Vafidemstat(ORY-2001) is a potent, selective, brain-penetrant dual inhibitor of lysine-specific histone demethylase (LSD1, KDM1A) and MAO-B, with IC50 values of 105 nM and 58 nM, respectively. It shows potential for treating memory deficits and behavioral alterations in neurodegenerative and psychiatric diseases.
E4823^New	Pargyline	Pargyline is an irreversible selective inhibitor of monoamine oxidase (MAO) with Kis of 13 μM and 0.5 μM for MAO-A and MAO-B respectively. It has pharmaceutical potential as an anticancer drug for human prostate cancer.
S9463^New	Demecarium Bromide	Demecarium Bromide, an anticholinesterase, is an inhibitor of monoamine oxidase (MAO). It induces long-term miosis and decreases intraocular pressure (IOP) in normotensive eyes of Beagles and of eyes of Beagles with inherited glaucoma.
E4805^New	Methylene Blue trihydrate	Methylene blue trihydrate (C.I. Basic Blue 9 trihydrate) acts as an inhibitor of soluble guanylyl cyclase (sGC), monoamine oxidase A (MAO-A) and NO synthase (NOS). Methylene blue trihydrate exhibits antimalarial, antidepressant, and anxiolytic activity effects. Methylene Blue trihydrate has potential applications in treating methemoglobinemia, neurodegenerative disorders, and ifosfamide-induced encephalopathy.

MAO阻害剤の選択性比較