S2302 |
Glycyrrhizin (NSC 167409)
|
Glycyrrhizin (NSC 167409, Glycyrrhizic Acid) is a direct HMGB1(high mobility group box 1) inhibitor that inhibits HMGB1-dependent inflammatory molecule expression and oxidative stress; modulates P38 and P-JNK but not p-ERK signalling; Also inhibits 11 beta-hydroxysteroid dehydrogenase and monoamine oxidase (MAO). |
-
Ecotoxicol Environ Saf, 2024, 272:116068
-
Front Immunol, 2023, 14:1024706
-
Front Immunol, 2023, 10.3389/fimmu.2023.1024706
|
|
S4246 |
Tranylcypromine HCl
|
Tranylcypromine HCl is a monoamine oxidase inhibitor, which inhibits CYP2A6 with Ki of 0.08 μM and 0.2 μM in cDNA-expressing microsomes and Human Liver Microsomes, respectively. |
-
Cell Rep, 2023, 42(6):112566
-
Biomolecules, 2023, 13(3)521
-
Biomolecules, 2023, 13(3)521
|
|
S9464 |
Tranylcypromine Sulfate
|
Tranylcypromine Sulfate is an irreversible inhibitor of monoamine oxidase (MAO) with a rapid onset of activity. |
-
Int J Mol Sci, 2022, 23(8)4213
-
Nan Fang Yi Ke Da Xue Xue Bao, 2021, 41(3):418-423
-
Nat Methods, 2020, 17(5):495-503
|
|
S3212 |
Moclobemide (Ro 111163)
|
Moclobemide is a MAO-A (5-HT) inhibitor with IC50 of 6.1 μM. |
-
J Gerontol A Biol Sci Med Sci, 2022, 77-8:1485-1493
-
Biol Reprod, 2021, ioab182
-
Pharmacol Biochem Behav, 2018, 166:13-20
|
|
S2102 |
Rasagiline Mesylate
|
Rasagiline Mesylate (TVP-1012,(R)-AGN1135 mesylate,TVP1012 mesylate) is a new MAO-B inhibitor for the treatment of idiopathic Parkinson's disease. |
-
Front Pharmacol, 2022, 13:1004215
-
EMBO Mol Med, 2021, e13929
|
|
S4033 |
Sennoside A
|
Sennoside A (NSC 112929), a kind of irritant laxative isolated from rhei rhizome, causes purgative actions in the intestine. |
-
Sci Adv, 2022, 8(15):eabm3471
-
Front Pharmacol, 2020, 11:566099
|
|
S3690 |
Pargyline hydrochloride
|
Pargyline is an irreversible inhibitor of monoamine oxidase (MAO)-B with Ki values of 13 and 0.5 μM for time-dependent inhibition of the activity of MAO-A and -B, respectivey. |
-
Genome Med, 2021, 13(1):168
-
Cancer Lett, 2017, 398:12-21
|
|
S2339 |
Paeonol
|
Paeonol (Peonol), a phenolic compound extracted from Chinese herbs Paeonia suffruticosa (moutan cortex) and Cynanchum paniculatum, inhibits MAO with an IC50 of about 50 μM. |
-
Biochem Biophys Res Commun, 2023, 656:86-96
-
Int J Biol Sci, 2019, 15(11):2497-2508
|
|
S3868 |
Harmine
|
Harmine (Telepathine), a fluorescent harmala alkaloid belonging to the beta-carboline family of compounds, is a highly cell-permeant and competitive inhibitor of ATP binding to the kinase pocket of DYRK1A, with about 60-fold higher IC50 value for DYRK2. Harmine also inhibits monoamine oxidases (MAOs), PPARγ and cdc-like kinases (CLKs). Harmine inhibits 5-HT2A serotonin receptor with Ki of 397 nM. |
-
J Gerontol A Biol Sci Med Sci, 2022, 77-8:1485-1493
-
Cell Death Dis, 2019, 10(12):899
|
|
S5269 |
J147
|
J147, a curcumin derivative, is a potent neurogenic and neuroprotective compound developed for the treatment of neurodegenerative conditions associated with aging. |
-
J Mol Histol, 2023, 54(6):725-738.
|
|
S3817 |
Harmine hydrochloride
|
Harmine (Telepathine), a fluorescent harmala alkaloid belonging to the beta-carboline family of compounds, is a highly cell-permeant and competitive inhibitor of ATP binding to the kinase pocket of DYRK1A, with about 60-fold higher IC50 value for DYRK2. Harmine also inhibits monoamine oxidases (MAOs), PPARγ and cdc-like kinases (CLKs). Harmine inhibits 5-HT2A serotonin receptor with Ki of 397 nM. |
-
Cancers (Basel), 2022, 14(2)326
|
|
S5795 |
Rasagiline
|
Rasagiline (TVP-1012) is a novel selective and irreversible MAO-B propargylamine inhibitor with in vitro IC50s of 4.43 nM and 412 nM for MAO-B and MAO-A, respectively. |
-
EMBO Mol Med, 2021, e13929
|
|
S4717 |
Isatin
|
Isatin (2,3-Indolinedione) is an endogenous MAO inhibitor and more active against MAO-B than MAO-A |
-
Cell Rep, 2022, 38(13):110559
|
|
S1472 |
Safinamide Mesylate
|
Safinamide Mesylate (PNU-151774E, FCE28073) is mesylate salt of Safinamide, selectively and reversibly inhibits MAO-B with IC50 of 98 nM, exhibits 5918-fold selectivity against MAO-A. Phase 3. |
|
|
S4856 |
Iproniazid
|
Iproniazid (Marsilid, Iprazid) is a non-selective, irreversible monoamine oxidase (MAO) inhibitor (MAOI) that is used as an antidepressive agent. |
|
|
S5357 |
Safinamide
|
Safinamide (EMD-1195686, PNU-15774E) is an orally active, selective, reversible monoamine oxidase-B inhibitor with both dopaminergic and non-dopaminergic (glutamatergic) properties. The IC50 value of safinamide for MAO-B is 98 nM. |
|
|
E2632 |
Norharmane
|
Norharmane (Norharman) is a potent and selective monoamine oxidase A (MAO-A) inhibitor with a Ki of 3.34 μM. |
|
|
S3273 |
Hypericin
|
Hypericin (Hyp, HY) is a naturally occurring substance found in the common St. John's Wort (Hypericum species) with antidepressive, antineoplastic and antiviral (human immunodeficiency and hepatitis C virus) activities. Hypericin has inhibitory effects on MAO (monoaminoxidase), PKC (protein kinase C), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450). |
-
Eur J Pharmacol, 2021, 900:174071
|
|
S9894New |
Vafidemstat
|
Vafidemstat(ORY-2001) is a potent, selective, brain-penetrant dual inhibitor of lysine-specific histone demethylase (LSD1, KDM1A) and MAO-B, with IC50 values of 105 nM and 58 nM, respectively. It shows potential for treating memory deficits and behavioral alterations in neurodegenerative and psychiatric diseases. |
|
|
S3291 |
Myristicin
|
Myristicin (Myristicine), a terpene-like active component in Nutmeg which is the seed of Myristica fragrans, is a weak inhibitor of monamine oxidase (MAO) and a mechanism-based inhibitor of CYP1A2. |
|
|
E4823New |
Pargyline
|
Pargyline is an irreversible selective inhibitor of monoamine oxidase (MAO) with Kis of 13 μM and 0.5 μM for MAO-A and MAO-B respectively. It has pharmaceutical potential as an anticancer drug for human prostate cancer. |
|
|
S6602 |
TB5
|
TB5 is a potent and selective MAO-B inhibitor with Ki values of 110 and 1,450 nM for MAO-B and MAO-A, respectively. |
|
|
S5663 |
Minaprine dihydrochloride
|
Minaprine dihydrochloride is hydrochloride salt form of Minaprine, which acts as a reversible inhibitor of MAO-A in rats and weakly inhibit acetylcholinesterase in rat brain (striatum) homogenates. |
|
|
E0165 |
Phenelzine sulfate
|
Phenelzine Sulfate is a hydrazine derivative and acts as a potent non-selective monoamine oxidase (MAO) inhibitor with an IC50 of 0.9 μM.
|
|
|
E0009 |
Harmane
|
Harmane (Harman, Aribine, Aribin, Locuturine, Locuturin, Loturine, Passiflorin, 1-Methylnorharman, NSC 54439) is a common compound in several foods, plants and beverages. Harmane is a selective monoamine oxidase inhibitors with IC50s of 0.5 μM and 5 μM for human MAO A and MAO B, respectively. Harmane also inhibits the apurinic/apyrimidinic (AP) endonuclease activity of the UV endonuclease induced by phage T4. |
|
|
S9463New |
Demecarium Bromide
|
Demecarium Bromide, an anticholinesterase, is an inhibitor of monoamine oxidase (MAO). It induces long-term miosis and decreases intraocular pressure (IOP) in normotensive eyes of Beagles and of eyes of Beagles with inherited glaucoma. |
|
|
E4805New |
Methylene Blue trihydrate
|
Methylene blue trihydrate (C.I. Basic Blue 9 trihydrate) acts as an inhibitor of soluble guanylyl cyclase (sGC), monoamine oxidase A (MAO-A) and NO synthase (NOS). Methylene blue trihydrate exhibits antimalarial, antidepressant, and anxiolytic activity effects. Methylene Blue trihydrate has potential applications in treating methemoglobinemia, neurodegenerative disorders, and ifosfamide-induced encephalopathy. |
|
|
S6422 |
Lazabemide
|
Lazabemide (Ro 19-6327) is a reversible and selective inhibitor of monoamine oxidase B (MAO-B) with Ki value of 7.9 nM. |
|
|
S0160 |
Toloxatone (MD69276)
|
Toloxatone (MD69276, Humoryl, Perenum, Umoril) is a reversible inhibitor of monoamine oxidase A (MAO-A) with IC50 of 0.93 µM. Toloxatone is an antidepressant agent. |
|
|
E2226 |
4-Hydroxyderricin
|
4-Hydroxyderricin(4-HD), the major active ingredients of Angelica keiskei Koidzumi, is a potent selective monoamine oxidase (MAO) inhibitor with mild inhibitory effect on dopamine β-hydroxylase. |
|
|
S6462 |
Amezinium (methylsulfate)
|
Amezinium is a sympathomimetic used for its vasopressor effects in the treatment of hypotensive states. It is a MAO inhibitor, antagonizes the response to tyramine and blocks neuronal uptake of noradrenaline. |
|
|
E2231 |
Xanthoangelol
|
Xanthoangelol, a chalcone found in the roots of Angelica keiskei, is a nonselective monoamine oxidase (MAO) inhibitor and a potent dopamine β-hydroxylase (DBH) inhibitor. It has anti-inflammatory, antibiotic and pro-apoptotic activities. |
|
|
S2419 |
Eprobemide
|
Eprobemide (Befol, LIS 630) is a reversible monoamine oxidase A (MAO-A) inhibitor. Eprobemide acts as an antidepressant in Russia. |
|
|
S4483 |
Iproniazid phosphate
|
Iproniazid (Marsilid, Iprazid) phosphate is a non-selective, irreversible monoamine oxidase (MAO) inhibitor (MAOI) that is used as an antidepressive agent. |
|
|
E0784 |
MAO-B-IN-2
|
MAO-B-IN-2 is a selective and competitive inhibitor of MAO-B and BChE with IC50 values of 0.51 and 7.00 μM, respectively. |
|
|
S2302 |
Glycyrrhizin (NSC 167409)
|
Glycyrrhizin (NSC 167409, Glycyrrhizic Acid) is a direct HMGB1(high mobility group box 1) inhibitor that inhibits HMGB1-dependent inflammatory molecule expression and oxidative stress; modulates P38 and P-JNK but not p-ERK signalling; Also inhibits 11 beta-hydroxysteroid dehydrogenase and monoamine oxidase (MAO). |
- Ecotoxicol Environ Saf, 2024, 272:116068
- Front Immunol, 2023, 14:1024706
- Front Immunol, 2023, 10.3389/fimmu.2023.1024706
|
|
S4246 |
Tranylcypromine HCl
|
Tranylcypromine HCl is a monoamine oxidase inhibitor, which inhibits CYP2A6 with Ki of 0.08 μM and 0.2 μM in cDNA-expressing microsomes and Human Liver Microsomes, respectively. |
- Cell Rep, 2023, 42(6):112566
- Biomolecules, 2023, 13(3)521
- Biomolecules, 2023, 13(3)521
|
|
S9464 |
Tranylcypromine Sulfate
|
Tranylcypromine Sulfate is an irreversible inhibitor of monoamine oxidase (MAO) with a rapid onset of activity. |
- Int J Mol Sci, 2022, 23(8)4213
- Nan Fang Yi Ke Da Xue Xue Bao, 2021, 41(3):418-423
- Nat Methods, 2020, 17(5):495-503
|
|
S3212 |
Moclobemide (Ro 111163)
|
Moclobemide is a MAO-A (5-HT) inhibitor with IC50 of 6.1 μM. |
- J Gerontol A Biol Sci Med Sci, 2022, 77-8:1485-1493
- Biol Reprod, 2021, ioab182
- Pharmacol Biochem Behav, 2018, 166:13-20
|
|
S2102 |
Rasagiline Mesylate
|
Rasagiline Mesylate (TVP-1012,(R)-AGN1135 mesylate,TVP1012 mesylate) is a new MAO-B inhibitor for the treatment of idiopathic Parkinson's disease. |
- Front Pharmacol, 2022, 13:1004215
- EMBO Mol Med, 2021, e13929
|
|
S4033 |
Sennoside A
|
Sennoside A (NSC 112929), a kind of irritant laxative isolated from rhei rhizome, causes purgative actions in the intestine. |
- Sci Adv, 2022, 8(15):eabm3471
- Front Pharmacol, 2020, 11:566099
|
|
S3690 |
Pargyline hydrochloride
|
Pargyline is an irreversible inhibitor of monoamine oxidase (MAO)-B with Ki values of 13 and 0.5 μM for time-dependent inhibition of the activity of MAO-A and -B, respectivey. |
- Genome Med, 2021, 13(1):168
- Cancer Lett, 2017, 398:12-21
|
|
S2339 |
Paeonol
|
Paeonol (Peonol), a phenolic compound extracted from Chinese herbs Paeonia suffruticosa (moutan cortex) and Cynanchum paniculatum, inhibits MAO with an IC50 of about 50 μM. |
- Biochem Biophys Res Commun, 2023, 656:86-96
- Int J Biol Sci, 2019, 15(11):2497-2508
|
|
S3868 |
Harmine
|
Harmine (Telepathine), a fluorescent harmala alkaloid belonging to the beta-carboline family of compounds, is a highly cell-permeant and competitive inhibitor of ATP binding to the kinase pocket of DYRK1A, with about 60-fold higher IC50 value for DYRK2. Harmine also inhibits monoamine oxidases (MAOs), PPARγ and cdc-like kinases (CLKs). Harmine inhibits 5-HT2A serotonin receptor with Ki of 397 nM. |
- J Gerontol A Biol Sci Med Sci, 2022, 77-8:1485-1493
- Cell Death Dis, 2019, 10(12):899
|
|
S5269 |
J147
|
J147, a curcumin derivative, is a potent neurogenic and neuroprotective compound developed for the treatment of neurodegenerative conditions associated with aging. |
- J Mol Histol, 2023, 54(6):725-738.
|
|
S3817 |
Harmine hydrochloride
|
Harmine (Telepathine), a fluorescent harmala alkaloid belonging to the beta-carboline family of compounds, is a highly cell-permeant and competitive inhibitor of ATP binding to the kinase pocket of DYRK1A, with about 60-fold higher IC50 value for DYRK2. Harmine also inhibits monoamine oxidases (MAOs), PPARγ and cdc-like kinases (CLKs). Harmine inhibits 5-HT2A serotonin receptor with Ki of 397 nM. |
- Cancers (Basel), 2022, 14(2)326
|
|
S5795 |
Rasagiline
|
Rasagiline (TVP-1012) is a novel selective and irreversible MAO-B propargylamine inhibitor with in vitro IC50s of 4.43 nM and 412 nM for MAO-B and MAO-A, respectively. |
- EMBO Mol Med, 2021, e13929
|
|
S4717 |
Isatin
|
Isatin (2,3-Indolinedione) is an endogenous MAO inhibitor and more active against MAO-B than MAO-A |
- Cell Rep, 2022, 38(13):110559
|
|
S1472 |
Safinamide Mesylate
|
Safinamide Mesylate (PNU-151774E, FCE28073) is mesylate salt of Safinamide, selectively and reversibly inhibits MAO-B with IC50 of 98 nM, exhibits 5918-fold selectivity against MAO-A. Phase 3. |
|
|
S4856 |
Iproniazid
|
Iproniazid (Marsilid, Iprazid) is a non-selective, irreversible monoamine oxidase (MAO) inhibitor (MAOI) that is used as an antidepressive agent. |
|
|
S5357 |
Safinamide
|
Safinamide (EMD-1195686, PNU-15774E) is an orally active, selective, reversible monoamine oxidase-B inhibitor with both dopaminergic and non-dopaminergic (glutamatergic) properties. The IC50 value of safinamide for MAO-B is 98 nM. |
|
|
E2632 |
Norharmane
|
Norharmane (Norharman) is a potent and selective monoamine oxidase A (MAO-A) inhibitor with a Ki of 3.34 μM. |
|
|
S3273 |
Hypericin
|
Hypericin (Hyp, HY) is a naturally occurring substance found in the common St. John's Wort (Hypericum species) with antidepressive, antineoplastic and antiviral (human immunodeficiency and hepatitis C virus) activities. Hypericin has inhibitory effects on MAO (monoaminoxidase), PKC (protein kinase C), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450). |
- Eur J Pharmacol, 2021, 900:174071
|
|
S9894New |
Vafidemstat
|
Vafidemstat(ORY-2001) is a potent, selective, brain-penetrant dual inhibitor of lysine-specific histone demethylase (LSD1, KDM1A) and MAO-B, with IC50 values of 105 nM and 58 nM, respectively. It shows potential for treating memory deficits and behavioral alterations in neurodegenerative and psychiatric diseases. |
|
|
S3291 |
Myristicin
|
Myristicin (Myristicine), a terpene-like active component in Nutmeg which is the seed of Myristica fragrans, is a weak inhibitor of monamine oxidase (MAO) and a mechanism-based inhibitor of CYP1A2. |
|
|
E4823New |
Pargyline
|
Pargyline is an irreversible selective inhibitor of monoamine oxidase (MAO) with Kis of 13 μM and 0.5 μM for MAO-A and MAO-B respectively. It has pharmaceutical potential as an anticancer drug for human prostate cancer. |
|
|
S6602 |
TB5
|
TB5 is a potent and selective MAO-B inhibitor with Ki values of 110 and 1,450 nM for MAO-B and MAO-A, respectively. |
|
|
S5663 |
Minaprine dihydrochloride
|
Minaprine dihydrochloride is hydrochloride salt form of Minaprine, which acts as a reversible inhibitor of MAO-A in rats and weakly inhibit acetylcholinesterase in rat brain (striatum) homogenates. |
|
|
E0165 |
Phenelzine sulfate
|
Phenelzine Sulfate is a hydrazine derivative and acts as a potent non-selective monoamine oxidase (MAO) inhibitor with an IC50 of 0.9 μM.
|
|
|
E0009 |
Harmane
|
Harmane (Harman, Aribine, Aribin, Locuturine, Locuturin, Loturine, Passiflorin, 1-Methylnorharman, NSC 54439) is a common compound in several foods, plants and beverages. Harmane is a selective monoamine oxidase inhibitors with IC50s of 0.5 μM and 5 μM for human MAO A and MAO B, respectively. Harmane also inhibits the apurinic/apyrimidinic (AP) endonuclease activity of the UV endonuclease induced by phage T4. |
|
|
S9463New |
Demecarium Bromide
|
Demecarium Bromide, an anticholinesterase, is an inhibitor of monoamine oxidase (MAO). It induces long-term miosis and decreases intraocular pressure (IOP) in normotensive eyes of Beagles and of eyes of Beagles with inherited glaucoma. |
|
|
E4805New |
Methylene Blue trihydrate
|
Methylene blue trihydrate (C.I. Basic Blue 9 trihydrate) acts as an inhibitor of soluble guanylyl cyclase (sGC), monoamine oxidase A (MAO-A) and NO synthase (NOS). Methylene blue trihydrate exhibits antimalarial, antidepressant, and anxiolytic activity effects. Methylene Blue trihydrate has potential applications in treating methemoglobinemia, neurodegenerative disorders, and ifosfamide-induced encephalopathy. |
|
|
S6422 |
Lazabemide
|
Lazabemide (Ro 19-6327) is a reversible and selective inhibitor of monoamine oxidase B (MAO-B) with Ki value of 7.9 nM. |
|
|
S0160 |
Toloxatone (MD69276)
|
Toloxatone (MD69276, Humoryl, Perenum, Umoril) is a reversible inhibitor of monoamine oxidase A (MAO-A) with IC50 of 0.93 µM. Toloxatone is an antidepressant agent. |
|
|
E2226 |
4-Hydroxyderricin
|
4-Hydroxyderricin(4-HD), the major active ingredients of Angelica keiskei Koidzumi, is a potent selective monoamine oxidase (MAO) inhibitor with mild inhibitory effect on dopamine β-hydroxylase. |
|
|
S6462 |
Amezinium (methylsulfate)
|
Amezinium is a sympathomimetic used for its vasopressor effects in the treatment of hypotensive states. It is a MAO inhibitor, antagonizes the response to tyramine and blocks neuronal uptake of noradrenaline. |
|
|
E2231 |
Xanthoangelol
|
Xanthoangelol, a chalcone found in the roots of Angelica keiskei, is a nonselective monoamine oxidase (MAO) inhibitor and a potent dopamine β-hydroxylase (DBH) inhibitor. It has anti-inflammatory, antibiotic and pro-apoptotic activities. |
|
|
S2419 |
Eprobemide
|
Eprobemide (Befol, LIS 630) is a reversible monoamine oxidase A (MAO-A) inhibitor. Eprobemide acts as an antidepressant in Russia. |
|
|
S4483 |
Iproniazid phosphate
|
Iproniazid (Marsilid, Iprazid) phosphate is a non-selective, irreversible monoamine oxidase (MAO) inhibitor (MAOI) that is used as an antidepressive agent. |
|
|
E0784 |
MAO-B-IN-2
|
MAO-B-IN-2 is a selective and competitive inhibitor of MAO-B and BChE with IC50 values of 0.51 and 7.00 μM, respectively. |
|
|