Levilimab (Anti-IL-6Ra / CD126)

製品コードA2983 別名: BCD-089

製品コード：A2983

Levilimab (Anti-IL-6Ra / CD126) is a fully human monoclonal antibody targeting interleukin-6 receptor (IL-6R). It is an inflammation-alleviating antibody and can be used for the research of rheumatoid arthritis and covid-19 treatment. MW :145.62 KD.

当該製品は品切れ状态で、ごメールアドレスを教えていただければ、在庫があると、メールで顧客様に伝えます。

「在庫のお知らせ」をクリックして、ごメールアドレスを入力していただくと、10％の割引を取得することができます。

在庫のお知らせ

質量管理及び製品安全説明書

Interleukins阻害剤の選択性比較

阻害剤	Citation	IL-6	IL-1	IL-8	IL-12	IL-10	IL-13	IL-2	その他
SKF-86002	0		++
JTE-607 Dihydrochloride	0	+++	+++	+++		+++			TNF-alpha
A-740003	2		++						rat P2X7 receptor,human P2X7 receptor
Apilimod mesylate	3				++++				PIKfyve
MD2-TLR4-IN-1	0	++							TLR4,TNF-α
Danirixin (GSK1325756)	2			++					CXCR2
Resatorvid (TAK-242)	56	++++							TLR4,NO,TNF-α
Apilimod	14				++++				PIKfyve
LMT-28	0	✔
Atractylodin	0	✔							NAAA
Triolein	0	✔							ROS,MMP-1
Ac-YVAD-cmk	4		✔
Diethyl phosphate	0	✔
RCM-1	3						✔		STAT6,FOXM1,β-catenin
Stylopine	0		✔						COX-2,TNF-α,NO
Myrislignan	1	✔							NF-κB,COX-2,iNOS
NE 52-QQ57	1		✔						iNOS,TNF-α,PGE2
PKR-IN-C16	6		✔						PKR
Falcarindiol	3	✔							STAT,ERK,JNK
Gardenoside	0		✔						P2X7 Receptor,P2X3 receptor,NF-κB
T-5224	17		✔						c-Jun,c-Fos/AP-1,Adamts-5
IQ 3	1	✔							TNF-α,JNK3,JNK1
Isuzinaxib (APX-115 free base)	0	✔							TNFα,MCP-1/CCL2,NOX2
AUDA	0		✔						p38,Smad3,TGF-β
SAR-20347	1				✔				IFN-α,TYK2,JAK1
SU 5201	0							✔
Madecassic acid	1		✔						TNF-α,COX-2,iNOS
Homoplantaginin	0	✔							NF-κB,IKKβ,TNF-α
2',5'-Dihydroxyacetophenone	1	✔							NF-κB,ERK1/2,iNOS
Forsythoside B	0	✔							NF-κB,TNF-alpha,IκB
Mulberroside A	0		✔						NF-κB,Caspase-1,NALP3
Chelidonic acid	0	✔							glutamate decarboxylase,Caspase-1,NF-κB
4-Methylesculetin	0	✔							MPO
Muscone	2		✔						TNF-α,NLRP3 inflammasome,NF-κB
Ossirene (AS101)	12		✔
Methylthiouracil	0	✔							ERK1/2,NF-κB,TNF-α

1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.

生物活性

製品説明	Levilimab (Anti-IL-6Ra / CD126) is a fully human monoclonal antibody targeting interleukin-6 receptor (IL-6R). It is an inflammation-alleviating antibody and can be used for the research of rheumatoid arthritis and covid-19 treatment. MW :145.62 KD.

参考
[1] Pum A, et al. Biomolecules. 2021 Jan 12;11(1):91.

参考

[1] Pum A, et al. Biomolecules. 2021 Jan 12;11(1):91.

製品説明

CAS No.	2035008-70-7
Molecular Weight	145.62
Formulation	100 mM Pro-Ac, 20mM Arg, pH5.0
Isotype	Human IgG1
Source	CHO
Storage (From the date of receipt)	Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles.
Shipping	Shipped under low temperature conditions
Purification	AKTA
Sterility	0.2 μM filtered

技術サポート

ストックの作り方、阻害剤の保管方法、細胞実験や動物実験の際に注意すべき点など、製品を取扱う時に問い合わせが多かった質問に対しては取扱説明書でお答えしています。

Handling Instructions

他に質問がある場合は、お気軽にお問い合わせください。

* 必須