Parasite

Parasite製品

All (48)
Parasite阻害剤 (48)
新製品

製品コード	製品名称	製品説明	文献中Selleckの製品使用例
S7379	E-64	E-64 is an irreversible and selective cysteine protease inhibitor, and also inhibits papain, calpain, and cathepsins B and H, but not serine proteases or aspartic proteases. The IC50 for papain is 9 nM. E-64 induces oxidative stress and apoptosis in Filarial Parasite.	Cancer Cell, 2022, 40(9):1044-1059.e8 Molecules, 2022, 27(6)1755 Nat Nanotechnol, 2021, 10.1038/s41565-021-00988-z
S5816	Pyrvinium pamoate	Pyrvinium pamoate(Pyrvinium embonate) is an anthelmintic effective for pinworms.	Endocrine, 2024, 10.1007/s12020-024-03887-0 Adv Healthc Mater, 2023, e2300591. Front Cell Infect Microbiol, 2022, 12:1074903
S4610	Mebendazole	Mebendazole is a synthetic benzimidazole derivate and anthelmintic agent. Mebendazole interferes with the reproduction and survival of helminths by inhibiting the formation of their cytoplasmic microtubules, thereby selectively and irreversibly blocking glucose uptake.	Cancers (Basel), 2022, 14(17)4196 Molecules, 2022, 27(23)8127 Adv Biol (Weinh), 2022, 6(8):e2200030
S3079	Atovaquone	Atovaquone (Atavaquone) is a medication used to treat or prevent for pneumocystis pneumonia, toxoplasmosis, malaria, and babesia.	Cells, 2024, 13(12)1025 iScience, 2024, 27(3):109172 J Cell Biochem, 2022, 10.1002/jcb.30213
S5948	Amodiaquine	Amodiaquine is a synthetic aminoquinoline that acts by binding to the protozoal or parasitic DNA and preventing DNA and RNA production and subsequent protein synthesis. It is used for the therapy of malaria.	Cell Death Discov, 2024, 10(1):434 Molecules, 2024, 29(6)1363 Nat Biomed Eng, 2021, 10.1038/s41551-021-00718-9
S4104	Diminazene Aceturate	Diminazene(Diminazene diaceturate) is a di-amidine also known as 4,4-(1-Triazene–1,3–diyl)bis(benzenecarboximidamide), used as an effective trypanocidal agent.	Cell, 2024, 187(15):4095-4112.e21 Cell, 2024, 187(15):4095-4112.e21 Bone Joint Res, 2024, 13(3):110-123
S1837	Flubendazole	Flubendazole (Flumoxanal, NSC 313680) is an autophagy inducer by targeting Atg4B, used to treat internal parasite and worm infection.	Nat Commun, 2024, 15(1):4513 Sci Rep, 2020, 10(1):13124 RSC Advances, 2018, 10.1039/C7RA12259D
S1691	Praziquantel	Praziquantel is an anthelmintic effective against flatworms.	Parasitology, 2020, 1-11 PLoS Negl Trop Dis, 2015, 9(3):e0003593
S2028	Diclazuril	Diclazuril(R-64433) is an anti-coccidial drug.	Hum Mol Genet, 2020, ddaa244
S1851	Oxibendazole	Oxibendazole is a benzimidazole drug that interferes with metabolic pathways, used to protect against roundworms, strongyles, threadworms, pinworms and lungworm infestations in horses and some domestic pets.	Oncol Lett, 2018, 15(2):2218-2226
S1830	Oxfendazole	Oxfendazole (RS-8858,Fenbendazole sulfoxide) is a broad spectrum benzimidazole anthelmintic.	Mol Med Rep, 2019, 19(4):2921-2926
S3741	Benznidazole	Benznidazole (Radanil) is a nitroimidazole derivative having an antiprotozoal activity by interfering with parasite protein biosynthesis, influencing cytokines production and stimulating host phagocytosis.	Int J Mol Sci, 2024, 25(8)4413 Microorganisms, 2022, 10(7)1421
S4422	Nitenpyram	Nitenpyram(Bestguard,Capstar) is a nicotinic acetylcholine receptor (AchR) agonist, used as veterinary medicine to treat parasites of livestock and pets.	Proc Natl Acad Sci U S A, 2020, 117(21):11321-11327
S5345	Nerolidol	Nerolidol (Peruviol) is a naturally occurring sesquiterpene found in the essential oils of many types of plants and flowers. It has diverse range of pharmacological and biological activities including antioxidant, anti-microbial, anti-biofilm, anti-parasitic, insecticidal, anti-ulcer, skin penetration enhancer, anti-tumor, anti-nociceptive and anti-inflammatory properties.	Int Immunopharmacol, 2020, 80:106118
S4068	Tinidazole	Tinidazole (CP12574) is an anti-parasitic drug.	Int J Mol Sci, 2024, 25(8)4413 Microorganisms, 2022, 10(7)1421
S3889	Arteether	Arteether is a well-known antimalarial drug which acts by producing free radicals within the malarial parasite.	ACS Infect Dis, 2020, 10.1021/acsinfecdis.0c00522
S5094	Maduramycin Ammonium	Maduramicin, which could be isolated from the actinomycete Actinomadura rubra, is an antiprotozoal agent used in veterinary medicine to prevent coccidiosis.	Cancers (Basel), 2019, 11(6)
S2468	Fenbendazole	Fenbendazole(Fenbendazol,Phenbendasol) is a broad spectrum benzimidazole anthelmintic used against gastrointestinal parasites with an IC50 of about 0.01 μg/mL.
S2501	Pyrantel Pamoate	Pyrantel pamoate (Pyrantel Embonate) is a depolarizing neuromuscular blocking agent.
S4141	Dinitolmide	Dinitolmide (Zoalene) is a broad-spectrum anticoccidial drug.
S4044	Toltrazuril	Toltrazuril is an antiprotozoal agent that acts upon Coccidia parasites.
S4094	Tetramisole HCl	Tetramisole(R-829,(±)-Tetramisole hydrochloride) is a mixture of dextro- and levo isomers used as an anthelmintic.
S3999	α-santonin	α-santonin, a naturally occurring sesquiterpene lactone, is a potent antiparasitic agent.
S4866	Nicarbazin	Nicarbazin, an effective anticoccidial, is also a wide-spectrum anti-parasitic drug.
S4876	Robenidine Hydrochloride	Robenidine Hydrochloride (Dexium, Nugatex, Rasexinium, Toraxine) is an anticoccidial agent mainly for poultry.
S4145	Decoquinate	Decoquinate is a coccidiostat.
S4599	Benzyl benzoate	Benzyl benzoate (Ascabiol, Novoscabin, Scabitox, Benzoic acid benzyl ester) is one of the older preparations used to treat scabies. Scabies is a skin infection caused by the mite sarcoptes scabiei.
S0081	DDD107498	DDD107498 (M-5717, DDD-498) is a P. falciparum translation elongation factor 2 inhibitor. DDD107498 exhibits a potent and novel spectrum of antimalarial activity against multiple life-cycle stages of the Plasmodium parasite.
S4167	Cyromazine	Cyromazine(Cyromazin,CGA-72662) is a triazine insect growth regulator used as an insecticide and an acaricide.
S5722	Oxantel Pamoate	Oxantel Pamoate is the pamoate salt form of oxantel, a tetrahydropyrimidine anthelmintic used against intesitnal worms, particularly in a veterinary setting.
S4898	Sulfalozine sodium	Sulfalozine sodium (Sulfaclozine sodium, Sulfachlopryrazine sodium) is an antiprotozoal useful in coccidiosis research.
S4882	Resorantel	Resorantel is a safe, hydroxybenzanilide cestocide highly effective against Moniezia and Thysaniezia spp. and moderately effective against Paramphistomum spp.
S5017	Oxyclozanide	Oxyclozanide (Oxiclozanidum, Zanil, Oxyclozanid, Zanilox) is a salicylanilide anthelmintic and mitochondrial uncoupling anthelmintic drug approved for veterinary use.
S3713	Moxidectin	Moxidectin (Milbemycin B) is a potent, broad-spectrum endectocide with activity against a wide range of nematodes, insects and acari.
S3707	Ethopabate	Ethopabate (ETP, Ethyl pabate) is a coccidiostat that is frequently used to prevent and treat coccidiosis in chickens.
S5055	Milbemycin Oxime	Milbemycin Oxime is a broad spectrum anti-parasitic drug that is active against worms (anthelmintic) and mites (miticide).
S5031	Sulfaquinoxaline sodium	Sulfaquinoxaline sodium (N'1-quinoxalin-2-ylsulphanilamide sodium, SQ-Na) is the sodium salt of sulfaquinoxaline, which is often used as a drug to prevent coccidiosis in poultry, swine, and sheep by inhibiting the synthesis of nucleic acids and proteins in microorganisms.
S3591	Eprinomectin	Eprinomectin (EPM, MK-397) is an excellent broad-spectrum endectocide with anthelmintic, insecticidal and miticidal activity.
S5093	Rafoxanide	Rafoxanide (Disalan, Ranide, Flukanide, Bovanide) is a salicylanilide used as an anthelmintic, being effective treatment for the control of fluke infections in animals.
S5092	Febantel	Febantel (Rintal, Combotel, Oratel, Bay Vh 5757, Negabot Plus) is a prodrug that is metabolized to fenbendazole and oxfendazole, which are undoubtedly the active parasiticides.
S5557	Aklomide	Aklomide (2-Chloro-4-nitrobenzamide) is a coccidiostat and used to fight disease, parasites and insects that infest poultry.
S4443	Piperazine adipate	Piperazine adipate is a broad spectrum anthelmintic agent that inhibits malate oxidation in Ascaridia galli and Heterakis gallinae.
S0467	Emodepside	Emodepside (QHT06, BAY 44-4400, PF 1022-221), a semisynthetic derivative of PF1022A, is a cyclooctadepsipeptide with broad-spectrum anthelmintic activity. Emodepside activates Ca-dependent SLO-1-like K channels.
S4389	Bephenium Hydroxynaphthoate	Bephenium(NSC 759245) is an activator of B-type Acetylcholine receptor (AChR). Bephenium selectively activates the Hco-L-AChR1 subtype made of Hco-UNC-29.1, Hco-UNC-38, Hco-UNC-63, Hco-ACR-8 subunits. Bephenium hydroxynaphthoate is an anthelmintic agent formerly used in the treatment of hookworm infections and ascariasis.
S4564	Diethylcarbamazine citrate	Diethylcarbamazine citrate is an inhibitor of arachidonic acid metabolism in filarial microfilaria and is highly specific for several parasites and does not contain any toxic metallic elements.
S4999	Avermectin B1	Avermectin B1 (Abamectin) is a widely used insecticide and anthelmintic.	Cancer Chemother Pharmacol, 2024, 94(4):599-613
S1265	SQ109	SQ109 is a potent inhibitor of the trypomastigote form of the parasite, with IC50 for LLC-MK2 culture-derived trypomastigotes of 50±8 nM, targets MmpL3 (mycobacterial membrane protein large 3) in Mycobacterium tuberculosis.
S5247	Selamectin	Selamectin (UK-124114) is a novel macrocyclic lactone of the avermectin class. It paralyses and/or kills a wide range of invertebrate parasites through interference with their chloride channel conductance causing disruption of normal neurotransmission and has adulticidal, ovicidal and larvicidal activity against fleas.
S7379	E-64	E-64 is an irreversible and selective cysteine protease inhibitor, and also inhibits papain, calpain, and cathepsins B and H, but not serine proteases or aspartic proteases. The IC50 for papain is 9 nM. E-64 induces oxidative stress and apoptosis in Filarial Parasite.	Cancer Cell, 2022, 40(9):1044-1059.e8 Molecules, 2022, 27(6)1755 Nat Nanotechnol, 2021, 10.1038/s41565-021-00988-z
S5816	Pyrvinium pamoate	Pyrvinium pamoate(Pyrvinium embonate) is an anthelmintic effective for pinworms.	Endocrine, 2024, 10.1007/s12020-024-03887-0 Adv Healthc Mater, 2023, e2300591. Front Cell Infect Microbiol, 2022, 12:1074903
S4610	Mebendazole	Mebendazole is a synthetic benzimidazole derivate and anthelmintic agent. Mebendazole interferes with the reproduction and survival of helminths by inhibiting the formation of their cytoplasmic microtubules, thereby selectively and irreversibly blocking glucose uptake.	Cancers (Basel), 2022, 14(17)4196 Molecules, 2022, 27(23)8127 Adv Biol (Weinh), 2022, 6(8):e2200030
S3079	Atovaquone	Atovaquone (Atavaquone) is a medication used to treat or prevent for pneumocystis pneumonia, toxoplasmosis, malaria, and babesia.	Cells, 2024, 13(12)1025 iScience, 2024, 27(3):109172 J Cell Biochem, 2022, 10.1002/jcb.30213
S5948	Amodiaquine	Amodiaquine is a synthetic aminoquinoline that acts by binding to the protozoal or parasitic DNA and preventing DNA and RNA production and subsequent protein synthesis. It is used for the therapy of malaria.	Cell Death Discov, 2024, 10(1):434 Molecules, 2024, 29(6)1363 Nat Biomed Eng, 2021, 10.1038/s41551-021-00718-9
S4104	Diminazene Aceturate	Diminazene(Diminazene diaceturate) is a di-amidine also known as 4,4-(1-Triazene–1,3–diyl)bis(benzenecarboximidamide), used as an effective trypanocidal agent.	Cell, 2024, 187(15):4095-4112.e21 Cell, 2024, 187(15):4095-4112.e21 Bone Joint Res, 2024, 13(3):110-123
S1837	Flubendazole	Flubendazole (Flumoxanal, NSC 313680) is an autophagy inducer by targeting Atg4B, used to treat internal parasite and worm infection.	Nat Commun, 2024, 15(1):4513 Sci Rep, 2020, 10(1):13124 RSC Advances, 2018, 10.1039/C7RA12259D
S1691	Praziquantel	Praziquantel is an anthelmintic effective against flatworms.	Parasitology, 2020, 1-11 PLoS Negl Trop Dis, 2015, 9(3):e0003593
S2028	Diclazuril	Diclazuril(R-64433) is an anti-coccidial drug.	Hum Mol Genet, 2020, ddaa244
S1851	Oxibendazole	Oxibendazole is a benzimidazole drug that interferes with metabolic pathways, used to protect against roundworms, strongyles, threadworms, pinworms and lungworm infestations in horses and some domestic pets.	Oncol Lett, 2018, 15(2):2218-2226
S1830	Oxfendazole	Oxfendazole (RS-8858,Fenbendazole sulfoxide) is a broad spectrum benzimidazole anthelmintic.	Mol Med Rep, 2019, 19(4):2921-2926
S3741	Benznidazole	Benznidazole (Radanil) is a nitroimidazole derivative having an antiprotozoal activity by interfering with parasite protein biosynthesis, influencing cytokines production and stimulating host phagocytosis.	Int J Mol Sci, 2024, 25(8)4413 Microorganisms, 2022, 10(7)1421
S4422	Nitenpyram	Nitenpyram(Bestguard,Capstar) is a nicotinic acetylcholine receptor (AchR) agonist, used as veterinary medicine to treat parasites of livestock and pets.	Proc Natl Acad Sci U S A, 2020, 117(21):11321-11327
S5345	Nerolidol	Nerolidol (Peruviol) is a naturally occurring sesquiterpene found in the essential oils of many types of plants and flowers. It has diverse range of pharmacological and biological activities including antioxidant, anti-microbial, anti-biofilm, anti-parasitic, insecticidal, anti-ulcer, skin penetration enhancer, anti-tumor, anti-nociceptive and anti-inflammatory properties.	Int Immunopharmacol, 2020, 80:106118
S4068	Tinidazole	Tinidazole (CP12574) is an anti-parasitic drug.	Int J Mol Sci, 2024, 25(8)4413 Microorganisms, 2022, 10(7)1421
S3889	Arteether	Arteether is a well-known antimalarial drug which acts by producing free radicals within the malarial parasite.	ACS Infect Dis, 2020, 10.1021/acsinfecdis.0c00522
S5094	Maduramycin Ammonium	Maduramicin, which could be isolated from the actinomycete Actinomadura rubra, is an antiprotozoal agent used in veterinary medicine to prevent coccidiosis.	Cancers (Basel), 2019, 11(6)
S2468	Fenbendazole	Fenbendazole(Fenbendazol,Phenbendasol) is a broad spectrum benzimidazole anthelmintic used against gastrointestinal parasites with an IC50 of about 0.01 μg/mL.
S2501	Pyrantel Pamoate	Pyrantel pamoate (Pyrantel Embonate) is a depolarizing neuromuscular blocking agent.
S4141	Dinitolmide	Dinitolmide (Zoalene) is a broad-spectrum anticoccidial drug.
S4044	Toltrazuril	Toltrazuril is an antiprotozoal agent that acts upon Coccidia parasites.
S4094	Tetramisole HCl	Tetramisole(R-829,(±)-Tetramisole hydrochloride) is a mixture of dextro- and levo isomers used as an anthelmintic.
S3999	α-santonin	α-santonin, a naturally occurring sesquiterpene lactone, is a potent antiparasitic agent.
S4866	Nicarbazin	Nicarbazin, an effective anticoccidial, is also a wide-spectrum anti-parasitic drug.
S4876	Robenidine Hydrochloride	Robenidine Hydrochloride (Dexium, Nugatex, Rasexinium, Toraxine) is an anticoccidial agent mainly for poultry.
S4145	Decoquinate	Decoquinate is a coccidiostat.
S4599	Benzyl benzoate	Benzyl benzoate (Ascabiol, Novoscabin, Scabitox, Benzoic acid benzyl ester) is one of the older preparations used to treat scabies. Scabies is a skin infection caused by the mite sarcoptes scabiei.
S0081	DDD107498	DDD107498 (M-5717, DDD-498) is a P. falciparum translation elongation factor 2 inhibitor. DDD107498 exhibits a potent and novel spectrum of antimalarial activity against multiple life-cycle stages of the Plasmodium parasite.
S4167	Cyromazine	Cyromazine(Cyromazin,CGA-72662) is a triazine insect growth regulator used as an insecticide and an acaricide.
S5722	Oxantel Pamoate	Oxantel Pamoate is the pamoate salt form of oxantel, a tetrahydropyrimidine anthelmintic used against intesitnal worms, particularly in a veterinary setting.
S4898	Sulfalozine sodium	Sulfalozine sodium (Sulfaclozine sodium, Sulfachlopryrazine sodium) is an antiprotozoal useful in coccidiosis research.
S4882	Resorantel	Resorantel is a safe, hydroxybenzanilide cestocide highly effective against Moniezia and Thysaniezia spp. and moderately effective against Paramphistomum spp.
S5017	Oxyclozanide	Oxyclozanide (Oxiclozanidum, Zanil, Oxyclozanid, Zanilox) is a salicylanilide anthelmintic and mitochondrial uncoupling anthelmintic drug approved for veterinary use.
S3713	Moxidectin	Moxidectin (Milbemycin B) is a potent, broad-spectrum endectocide with activity against a wide range of nematodes, insects and acari.
S3707	Ethopabate	Ethopabate (ETP, Ethyl pabate) is a coccidiostat that is frequently used to prevent and treat coccidiosis in chickens.
S5055	Milbemycin Oxime	Milbemycin Oxime is a broad spectrum anti-parasitic drug that is active against worms (anthelmintic) and mites (miticide).
S5031	Sulfaquinoxaline sodium	Sulfaquinoxaline sodium (N'1-quinoxalin-2-ylsulphanilamide sodium, SQ-Na) is the sodium salt of sulfaquinoxaline, which is often used as a drug to prevent coccidiosis in poultry, swine, and sheep by inhibiting the synthesis of nucleic acids and proteins in microorganisms.
S3591	Eprinomectin	Eprinomectin (EPM, MK-397) is an excellent broad-spectrum endectocide with anthelmintic, insecticidal and miticidal activity.
S5093	Rafoxanide	Rafoxanide (Disalan, Ranide, Flukanide, Bovanide) is a salicylanilide used as an anthelmintic, being effective treatment for the control of fluke infections in animals.
S5092	Febantel	Febantel (Rintal, Combotel, Oratel, Bay Vh 5757, Negabot Plus) is a prodrug that is metabolized to fenbendazole and oxfendazole, which are undoubtedly the active parasiticides.
S5557	Aklomide	Aklomide (2-Chloro-4-nitrobenzamide) is a coccidiostat and used to fight disease, parasites and insects that infest poultry.
S4443	Piperazine adipate	Piperazine adipate is a broad spectrum anthelmintic agent that inhibits malate oxidation in Ascaridia galli and Heterakis gallinae.
S0467	Emodepside	Emodepside (QHT06, BAY 44-4400, PF 1022-221), a semisynthetic derivative of PF1022A, is a cyclooctadepsipeptide with broad-spectrum anthelmintic activity. Emodepside activates Ca-dependent SLO-1-like K channels.
S4389	Bephenium Hydroxynaphthoate	Bephenium(NSC 759245) is an activator of B-type Acetylcholine receptor (AChR). Bephenium selectively activates the Hco-L-AChR1 subtype made of Hco-UNC-29.1, Hco-UNC-38, Hco-UNC-63, Hco-ACR-8 subunits. Bephenium hydroxynaphthoate is an anthelmintic agent formerly used in the treatment of hookworm infections and ascariasis.
S4564	Diethylcarbamazine citrate	Diethylcarbamazine citrate is an inhibitor of arachidonic acid metabolism in filarial microfilaria and is highly specific for several parasites and does not contain any toxic metallic elements.
S4999	Avermectin B1	Avermectin B1 (Abamectin) is a widely used insecticide and anthelmintic.	Cancer Chemother Pharmacol, 2024, 94(4):599-613
S1265	SQ109	SQ109 is a potent inhibitor of the trypomastigote form of the parasite, with IC50 for LLC-MK2 culture-derived trypomastigotes of 50±8 nM, targets MmpL3 (mycobacterial membrane protein large 3) in Mycobacterium tuberculosis.
S5247	Selamectin	Selamectin (UK-124114) is a novel macrocyclic lactone of the avermectin class. It paralyses and/or kills a wide range of invertebrate parasites through interference with their chloride channel conductance causing disruption of normal neurotransmission and has adulticidal, ovicidal and larvicidal activity against fleas.

Parasite阻害剤の選択性比較