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MMP
MMP製品
- All (32)
- MMP阻害剤 (30)
- MMP抗体(1)
- MMP活性剤(1)
- 新製品
| 製品コード | 製品名称 | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
|---|---|---|---|---|
| S7157 | Ilomastat (GM6001) | Ilomastat (GM6001) is a broad spectrum matrix metalloprotease (MMP) inhibitor for MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-12, MMP-14, and MMP-26 with Ki of 0.4 nM, 0.5 nM, 27 nM, 3.7 nM, 0.1 nM, 0.2 nM, 3.6 nM, 13.4 nM, 0.36 nM, respectively. |
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| S4163 | Doxycycline Hyclate | Doxycycline Hyclate is a member of the tetracycline antibiotics group, and is commonly used to treat a variety of infections. It is also an inhibitor of matrix metallo-proteinases (MMP). | ||
| S5159 | Doxycycline | Doxycycline (Vibramycin, Doxytetracycline, Doxiciclina, Doxycyclinum) is an antibiotic that is used in the treatment of a number of types of infections caused by bacteria and protozoa. Doxycycline is also a nonspecific matrix metalloproteinase (MMP) inhibitor. | ||
| S7155 | Batimastat (BB-94) | Batimastat (BB-94) is a potent, broad spectrum matrix metalloprotease (MMP) inhibitor for MMP-1, MMP-2, MMP-9, MMP-7 and MMP-3 with IC50 of 3 nM, 4 nM, 4 nM, 6 nM and 20 nM, respectively. Also inhibits the activitity of other metalloproteases, such as ADAM17. |
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| S7430 | SB-3CT | SB-3CT is an effective and selective gelatinase inhibitor with Ki of 13.9 nM and 600 nM for MMP-2 and MMP-9, respectively. |
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| S7434 | TAPI-1 | TAPI-1 is an ADAM17/TACE inhibitor, which blocks shedding of cytokine receptors. TAPI-1 is also an inhibitor of Matrix Metalloproteinase (MMP). |
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| S7156 | Marimastat (BB-2516) | Marimastat (BB-2516, TA2516) is a broad spectrum matrix metalloprotease (MMP) inhibitor for MMP-9, MMP-1, MMP-2, MMP-14 and MMP-7 with IC50 of 3 nM, 5 nM, 6 nM, 9 nM and 13 nM, respectively. Phase 3. |
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| S8966 | T-5224 | T-5224 is a selective inhibitor of transcription factor c-Fos/activator protein (AP)-1 with anti-inflammatory effects. T-5224 specifically inhibits the DNA binding activity of c-Fos/c-Jun and the IL-1β-induced up-regulation of Mmp-3, Mmp-13 and Adamts-5 transcription. | ||
| S2333 | Nobiletin | Nobiletin, a citrus flavonoid isolated from citrus peels like in tangerine, which has anti-inflammatory and anti-tumor activities. |
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| S8072 | NSC 405020 | NSC 405020 is a noncatalytic inhibitor of MT1-MMP, directly interacts with PEX domain of MT1-MMP, affects PEX homodimerization but not catalytic activity of MT1-MMP. | ||
| S0769 | MMP-9-IN-1 | MMP-9-IN-1 (OUN87710) is a specific inhibitor of matrix metalloproteinase-9 (MMP-9). MMP-9-IN-1 selectively targets the hemopexin (PEX) domain of MMP-9 with Kd of 2.1 μM. | ||
| S5696 | JNJ0966 | JNJ0966 is a highly selective compound that inhibits activation of MMP-9 zymogen and subsequent generation of catalytically active enzyme. It has no effect on MMP-1, MMP-2, MMP-3, MMP-9, or MMP-14 catalytic activity and did not inhibit activation of the highly related MMP-2 zymogen. | ||
| S3610 | Cordycepin | Cordycepin (3'-Deoxyadenosine) is an adenosine analogue, which is readily phosphorylated to its mono-, di-, and triphosphate intracellularly. It has a very potent anti-cancer, anti-oxidant and anti-inflammatory activities. | ||
| S5543 | 1, 10-Phenanthroline monohydrate | 1,10-Phenanthroline is a classic chelating bidentate ligand for transition metal ions that has played an important role in the development of coordination chemistry. It is an inhibitor of metallopeptidases. | ||
| S6830 | o-Phenanthroline | o-Phenanthroline (1,10-Phenanthroline, phen), a hypoxia-mimicking agent, is a non-specific matrix metalloproteinase (MMP) inhibitor with IC50 of 110.5μM for Collagenase. O-phenanthroline reduces the expression of MMP3 and MMP13 mRNA levels during chondrogenic differentiation of human chondrocytes (hChs), as well as after TNFα/IL-1β exposure in an explant model. o-Phenanthroline is also a metal chelator which prevents the induction of chromosomal aberrations in streptozotocin-treated cells and forms a red chelate with Fe2+ that absorbs maximally at 510 nm. | ||
| S5752 | Abametapir | Abametapir (HA-44, BRN 0123183), the active ingredient of Xeglyze Lotion, is an inhibitor of metalloproteinases critical for louse survival and egg development. | ||
| S4964 | Lactobionic acid | Lactobionic acid (Galactosylgluconic acid), an α-hydroxyacid (AHA) with antioxidation activity, is used in the development of cosmeceuticals for skin. | ||
| E0073 | CL-82198 | CL-82198 is a selective, orally bioavailable MMP-13 inhibitor with an IC50 of 3.2 μM. | ||
| S9052 | Auraptene | Auraptene (7-geranyloxycoumarin) is a natural coumarin derived from citrus plants and possesses valuable pharmacological properties, including anticarcinogenic, anti-inflammatory, antihelicobacter, antigenotoxic, and neuroprotective effects. Auraptene inhibits matrix metalloproteinase 2 (MMP-2) as well as key inflammatory mediators, including IL-6, IL-8 and chemokine (C-C motif) ligand-5(CCL5). | ||
| S4005New | Doxycycline HCl | Doxycycline HCl is a tetracycline antibiotic that commonly used to treat a variety of infections, and also a MMP inhibitor. | ||
| S0923 | Isoliquiritin apioside | Isoliquiritin apioside (ISLA, ILA), a component isolated from Glycyrrhizae radix rhizome (GR), significantly decreases PMA-induced increases in matrix metalloproteinase (MMP) activities and suppresses PMA-induced activation of mitogen-activated protein kinase (MAPK) and NF-κB. Isoliquiritin apioside possesses anti-metastatic and anti-angiogenic abilities in malignant cancer cells and ECs, with no cytotoxicity. | ||
| S3590 | Triolein | Triolein is an inhibitor of metalloproteinase-1 (MMP-1) and reduces both the expression of IL-6 and ROS generation in irradiated keratinocytes. | ||
| A2399 | Andecaliximab (Anti-MMP9) | Andecaliximab (Anti-MMP9) is a recombinant chimeric IgG4 monoclonal antibody (mAb) that targets matrix metalloproteinase 9 (MMP9). Andecaliximab shows antifibrotic efficacy in idiopathic pulmonary fibrosis mouse models. MW: 145.5 kD. | ||
| S0752 | AUDA | AUDA (compound 43) is a potent inhibitor of soluble epoxide hydrolase (sEH) with IC50 of 18 nM and 69 nM for the mouse sEH and human sEH, respectively. AUDA has anti-inflammatory activity that reduces the protein expression of MMP-9, IL-1β, TNF-α and TGF-β. AUDA downregulates Smad3 and p38 signaling pathways. | ||
| S4884 | Trans-Zeatin | Trans-Zeatina ((E)-Zeatin) is the member of the plant growth hormone family known as cytokinins, which regulate cell division, development, and nutrient processing. Trans-Zeatin inhibits UVB-induced MMP-1 expression, c-Jun activation and phosphorylation of ERK, JNK and p38 MAP kinases (MAPKs) dose-dependently. | ||
| S0341 | T-26c | T-26c is a highly potent and selective inhibitor of matrix metalloproteinase-13 (MMP-13) with IC50 of 6.9 pM, more than 2600-fold selectivity over other related metalloenzymes. | ||
| S3781 | Ginkgolide C | Ginkgolide C (BN-52022), isolated from Ginkgo biloba leaves, is a flavone reported to have multiple biological functions, from decreased platelet aggregation to ameliorating Alzheimer disease. It is an activator of MMP-9. | ||
| S3309 | Solasodine | Solasodine (Purapuridine, Solancarpidine, Solasodin, Salasodine, Salasdine) is a poisonous alkaloid chemical compound that occurs in plants of the Solanaceae family. Solasodine reduces the mRNA level of matrix metalloproteinase-2 (MMP-2), MMP-9 and extracellular inducer of matrix metalloproteinase (EMMPRIN), but increases the expression of reversion-inducing cysteine-rich protein with kazal motifs (RECK). Solasodine downregulates oncogenic microRNA-21 (miR-21), which has been known to target RECK. Solasodine also reduces PI3K/Akt signaling pathways and downregulates expression of miR-21. | ||
| S9386 | Polygalacic acid | Polygalacic acid is the triterpenoid tetrahydroxyacid isolated from Polygala paenea L.. Polygalacic acid (0-100 μM; 24 hours) significantly decreases the mRNAexpressions of MMP-3, MMP-9, MMP-13 and COX-2, which are significantly increased by IL-1β, in a dose-dependent manner. | ||
| S9909 | ARP 100 | ARP 100 (MMP-2 Inhibitor III, Compound 10a) is a potent and selective inhibitor of MMP-2 with an IC50 of 12 nM and displays less inhibitory activity at MMP-9, MMP-3, MMP-1 and MMP-7 with IC50s of 200 nM, 4500 nM, >50,000 nM and >50,000 nM respectively. | ||
| S5465 | Morroniside | Morroniside, an iridoid glycoside, is the main active ingredient from Cornus officinalis Sieb. et Zucc. and Sambucus williamsii Hance. It has therapeutic effects on diabetic angiopathies, renal damage, lipid metabolism and inflammation and bone resorption. | ||
| E0783 | SM-7368 | SM-7368 is a potent NF-κB inhibitor that targets downstream of MAPK p38 activation, also inhibits TNF-α-induced MMP-9 upregulation. | ||
| S7157 | Ilomastat (GM6001) | Ilomastat (GM6001) is a broad spectrum matrix metalloprotease (MMP) inhibitor for MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-12, MMP-14, and MMP-26 with Ki of 0.4 nM, 0.5 nM, 27 nM, 3.7 nM, 0.1 nM, 0.2 nM, 3.6 nM, 13.4 nM, 0.36 nM, respectively. |
|
|
| S4163 | Doxycycline Hyclate | Doxycycline Hyclate is a member of the tetracycline antibiotics group, and is commonly used to treat a variety of infections. It is also an inhibitor of matrix metallo-proteinases (MMP). | ||
| S5159 | Doxycycline | Doxycycline (Vibramycin, Doxytetracycline, Doxiciclina, Doxycyclinum) is an antibiotic that is used in the treatment of a number of types of infections caused by bacteria and protozoa. Doxycycline is also a nonspecific matrix metalloproteinase (MMP) inhibitor. | ||
| S7155 | Batimastat (BB-94) | Batimastat (BB-94) is a potent, broad spectrum matrix metalloprotease (MMP) inhibitor for MMP-1, MMP-2, MMP-9, MMP-7 and MMP-3 with IC50 of 3 nM, 4 nM, 4 nM, 6 nM and 20 nM, respectively. Also inhibits the activitity of other metalloproteases, such as ADAM17. |
|
|
| S7430 | SB-3CT | SB-3CT is an effective and selective gelatinase inhibitor with Ki of 13.9 nM and 600 nM for MMP-2 and MMP-9, respectively. |
|
|
| S7434 | TAPI-1 | TAPI-1 is an ADAM17/TACE inhibitor, which blocks shedding of cytokine receptors. TAPI-1 is also an inhibitor of Matrix Metalloproteinase (MMP). |
|
|
| S7156 | Marimastat (BB-2516) | Marimastat (BB-2516, TA2516) is a broad spectrum matrix metalloprotease (MMP) inhibitor for MMP-9, MMP-1, MMP-2, MMP-14 and MMP-7 with IC50 of 3 nM, 5 nM, 6 nM, 9 nM and 13 nM, respectively. Phase 3. |
|
|
| S8966 | T-5224 | T-5224 is a selective inhibitor of transcription factor c-Fos/activator protein (AP)-1 with anti-inflammatory effects. T-5224 specifically inhibits the DNA binding activity of c-Fos/c-Jun and the IL-1β-induced up-regulation of Mmp-3, Mmp-13 and Adamts-5 transcription. | ||
| S2333 | Nobiletin | Nobiletin, a citrus flavonoid isolated from citrus peels like in tangerine, which has anti-inflammatory and anti-tumor activities. |
|
|
| S8072 | NSC 405020 | NSC 405020 is a noncatalytic inhibitor of MT1-MMP, directly interacts with PEX domain of MT1-MMP, affects PEX homodimerization but not catalytic activity of MT1-MMP. | ||
| S0769 | MMP-9-IN-1 | MMP-9-IN-1 (OUN87710) is a specific inhibitor of matrix metalloproteinase-9 (MMP-9). MMP-9-IN-1 selectively targets the hemopexin (PEX) domain of MMP-9 with Kd of 2.1 μM. | ||
| S5696 | JNJ0966 | JNJ0966 is a highly selective compound that inhibits activation of MMP-9 zymogen and subsequent generation of catalytically active enzyme. It has no effect on MMP-1, MMP-2, MMP-3, MMP-9, or MMP-14 catalytic activity and did not inhibit activation of the highly related MMP-2 zymogen. | ||
| S3610 | Cordycepin | Cordycepin (3'-Deoxyadenosine) is an adenosine analogue, which is readily phosphorylated to its mono-, di-, and triphosphate intracellularly. It has a very potent anti-cancer, anti-oxidant and anti-inflammatory activities. | ||
| S5543 | 1, 10-Phenanthroline monohydrate | 1,10-Phenanthroline is a classic chelating bidentate ligand for transition metal ions that has played an important role in the development of coordination chemistry. It is an inhibitor of metallopeptidases. | ||
| S6830 | o-Phenanthroline | o-Phenanthroline (1,10-Phenanthroline, phen), a hypoxia-mimicking agent, is a non-specific matrix metalloproteinase (MMP) inhibitor with IC50 of 110.5μM for Collagenase. O-phenanthroline reduces the expression of MMP3 and MMP13 mRNA levels during chondrogenic differentiation of human chondrocytes (hChs), as well as after TNFα/IL-1β exposure in an explant model. o-Phenanthroline is also a metal chelator which prevents the induction of chromosomal aberrations in streptozotocin-treated cells and forms a red chelate with Fe2+ that absorbs maximally at 510 nm. | ||
| S5752 | Abametapir | Abametapir (HA-44, BRN 0123183), the active ingredient of Xeglyze Lotion, is an inhibitor of metalloproteinases critical for louse survival and egg development. | ||
| S4964 | Lactobionic acid | Lactobionic acid (Galactosylgluconic acid), an α-hydroxyacid (AHA) with antioxidation activity, is used in the development of cosmeceuticals for skin. | ||
| E0073 | CL-82198 | CL-82198 is a selective, orally bioavailable MMP-13 inhibitor with an IC50 of 3.2 μM. | ||
| S9052 | Auraptene | Auraptene (7-geranyloxycoumarin) is a natural coumarin derived from citrus plants and possesses valuable pharmacological properties, including anticarcinogenic, anti-inflammatory, antihelicobacter, antigenotoxic, and neuroprotective effects. Auraptene inhibits matrix metalloproteinase 2 (MMP-2) as well as key inflammatory mediators, including IL-6, IL-8 and chemokine (C-C motif) ligand-5(CCL5). | ||
| S4005New | Doxycycline HCl | Doxycycline HCl is a tetracycline antibiotic that commonly used to treat a variety of infections, and also a MMP inhibitor. | ||
| S0923 | Isoliquiritin apioside | Isoliquiritin apioside (ISLA, ILA), a component isolated from Glycyrrhizae radix rhizome (GR), significantly decreases PMA-induced increases in matrix metalloproteinase (MMP) activities and suppresses PMA-induced activation of mitogen-activated protein kinase (MAPK) and NF-κB. Isoliquiritin apioside possesses anti-metastatic and anti-angiogenic abilities in malignant cancer cells and ECs, with no cytotoxicity. | ||
| S3590 | Triolein | Triolein is an inhibitor of metalloproteinase-1 (MMP-1) and reduces both the expression of IL-6 and ROS generation in irradiated keratinocytes. | ||
| S0752 | AUDA | AUDA (compound 43) is a potent inhibitor of soluble epoxide hydrolase (sEH) with IC50 of 18 nM and 69 nM for the mouse sEH and human sEH, respectively. AUDA has anti-inflammatory activity that reduces the protein expression of MMP-9, IL-1β, TNF-α and TGF-β. AUDA downregulates Smad3 and p38 signaling pathways. | ||
| S4884 | Trans-Zeatin | Trans-Zeatina ((E)-Zeatin) is the member of the plant growth hormone family known as cytokinins, which regulate cell division, development, and nutrient processing. Trans-Zeatin inhibits UVB-induced MMP-1 expression, c-Jun activation and phosphorylation of ERK, JNK and p38 MAP kinases (MAPKs) dose-dependently. | ||
| S0341 | T-26c | T-26c is a highly potent and selective inhibitor of matrix metalloproteinase-13 (MMP-13) with IC50 of 6.9 pM, more than 2600-fold selectivity over other related metalloenzymes. | ||
| S3309 | Solasodine | Solasodine (Purapuridine, Solancarpidine, Solasodin, Salasodine, Salasdine) is a poisonous alkaloid chemical compound that occurs in plants of the Solanaceae family. Solasodine reduces the mRNA level of matrix metalloproteinase-2 (MMP-2), MMP-9 and extracellular inducer of matrix metalloproteinase (EMMPRIN), but increases the expression of reversion-inducing cysteine-rich protein with kazal motifs (RECK). Solasodine downregulates oncogenic microRNA-21 (miR-21), which has been known to target RECK. Solasodine also reduces PI3K/Akt signaling pathways and downregulates expression of miR-21. | ||
| S9386 | Polygalacic acid | Polygalacic acid is the triterpenoid tetrahydroxyacid isolated from Polygala paenea L.. Polygalacic acid (0-100 μM; 24 hours) significantly decreases the mRNAexpressions of MMP-3, MMP-9, MMP-13 and COX-2, which are significantly increased by IL-1β, in a dose-dependent manner. | ||
| S9909 | ARP 100 | ARP 100 (MMP-2 Inhibitor III, Compound 10a) is a potent and selective inhibitor of MMP-2 with an IC50 of 12 nM and displays less inhibitory activity at MMP-9, MMP-3, MMP-1 and MMP-7 with IC50s of 200 nM, 4500 nM, >50,000 nM and >50,000 nM respectively. | ||
| S5465 | Morroniside | Morroniside, an iridoid glycoside, is the main active ingredient from Cornus officinalis Sieb. et Zucc. and Sambucus williamsii Hance. It has therapeutic effects on diabetic angiopathies, renal damage, lipid metabolism and inflammation and bone resorption. | ||
| E0783 | SM-7368 | SM-7368 is a potent NF-κB inhibitor that targets downstream of MAPK p38 activation, also inhibits TNF-α-induced MMP-9 upregulation. | ||
| A2399 | Andecaliximab (Anti-MMP9) | Andecaliximab (Anti-MMP9) is a recombinant chimeric IgG4 monoclonal antibody (mAb) that targets matrix metalloproteinase 9 (MMP9). Andecaliximab shows antifibrotic efficacy in idiopathic pulmonary fibrosis mouse models. MW: 145.5 kD. | ||
| S3781 | Ginkgolide C | Ginkgolide C (BN-52022), isolated from Ginkgo biloba leaves, is a flavone reported to have multiple biological functions, from decreased platelet aggregation to ameliorating Alzheimer disease. It is an activator of MMP-9. | ||
| S4005New | Doxycycline HCl | Doxycycline HCl is a tetracycline antibiotic that commonly used to treat a variety of infections, and also a MMP inhibitor. |
MMP阻害剤の選択性比較
Tags: MMP inhibitor|MMP agonist|MMP activator|MMP inducer|MMP antagonist|MMP signaling pathway|MMP assay kit
納期 国内在庫品：受注日の翌日（15時までの受注分） ＊北海道、九州、沖縄への配送は受注日より２日以上 を要する場合あり 海外在庫品：受注後１〜２週間