S1322 |
Dexamethasone
|
Dexamethasone is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects. Dexamethasone induces autophagy and mitophagy. Dexamethasone is tested in hospitalized patients with COVID-19 and is found to have benefits for critically ill patients. |
-
Cell Host Microbe, 2024, S1931-3128(24)00005-2
-
Nat Commun, 2024, 15(1):7991
-
Nat Commun, 2024, 15(1):1176
|
|
S4028 |
Dexamethasone Sodium Phosphate
|
Dexamethasone (Dexamethasone 21-phosphate disodium salt) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects. |
-
Cancer Cell, 2024, 42(9):1507-1527.e11
-
Pharmaceutics, 2022, 14(2)400
-
Front Oncol, 2022, 12:888695
|
|
S1696 |
Hydrocortisone
|
Hydrocortisone is a steroid hormone or glucocorticoid produced by the adrenal gland. |
-
Int J Radiat Oncol Biol Phys, 2024, S0360-3016(24)00307-9
-
Cells, 2024, 13(14)1224
-
Neurobiol Stress, 2024, 28:100593
|
|
S2606 |
Mifepristone
|
Mifepristone is a remarkably active antagonist of progesterone receptor and glucocorticoid receptor with IC50 of 0.2 nM and 2.6 nM, respectively. Mifepristone promotes cell autophagy and apoptosis, decreases Bcl-2 level and increases Beclin1 level, accompanied by weakened interaction between Bcl-2 and Beclin1. |
-
Neuron, 2024, S0896-6273(24)00089-8
-
Cell Death Dis, 2024, 15(1):70
-
Cell Death Dis, 2024, 15(1):73
|
|
S1737 |
Prednisolone
|
Prednisolone is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. |
-
Molecules, 2024, 29(7)1546
-
Life Sci Alliance, 2023, 6(10)e202302009
-
Life Sci Alliance, 2023, 6(10)e202302009
|
|
S5956 |
Dexamethasone phosphate disodium
|
Dexamethasone phosphate disodium is a glucocorticoid receptor agonist with both anti-inflammatory and anti-oxidative effects. |
-
Cell Rep, 2023, 42(6):112566
-
Blood Adv, 2023, 7(4):469-481
-
Heliyon, 2023, 9(3):e14006
|
|
S2559 |
Cortisone acetate
|
Cortisone acetate (Cortone, NSC 49420) is an acetate salt form of cortisone that is a steroid hormone and a glucocorticoid. |
-
J Pers Med, 2022, 12(2)258
-
Hum Cell, 2022, 10.1007/s13577-022-00671-y
-
Hum Cell, 2021, 34(6):1911-1918
|
|
S1622 |
Prednisone
|
Prednisone is a synthetic corticosteroid agent that is particularly effective as an immunosuppressant compound. |
-
Blood Cancer J, 2022, 12(3):36
-
Int J Mol Sci, 2022, 23(7)3834
-
Front Immunol, 2021, 12:739605
|
|
S1286 |
Budesonide
|
Budesonide(Labazenit) is a glucocorticoid steroid for the treatment of asthma, non-infectious rhinitis. |
-
Front Mol Neurosci, 2024, 17:1473960
-
Front Immunol, 2023, 14:1097383
-
Front Immunol, 2023, 14:1097383
|
|
S4646 |
Ciclesonide
|
Ciclesonide (Alvesco, Omnaris, RPR251526, Zetonna) is a glucocorticoid used to treat obstructive airway diseases. |
-
Acta Pharm Sin B, 2023, 13(2):662-677
-
Am J Physiol Lung Cell Mol Physiol, 2023, 324(5):L722-L736
-
mBio, 2022, 13(1):e0304421
|
|
S1992 |
Fluticasone propionate
|
Fluticasone Propionate (CCI-187881) is a synthetic glucocorticoid, used to treat non-allergic and allergic rhinitis. |
-
Heliyon, 2024, 10(20):e39475
-
Cell Rep Methods, 2023, 3(4):100440
-
Cell Rep Methods, 2023, 3(4):100440
|
|
S1628 |
Triamcinolone Acetonide
|
Triamcinolone acetonide is a synthetic glucocorticoid, used in the symptomatic treatment of inflammation. |
-
J Transl Med, 2022, 20(1):561
-
J Inflamm Res, 2021, 14:843-858
-
Theranostics, 2020, 10(1):247-264
|
|
S2570 |
Prednisolone Acetate
|
Prednisolone Acetate (Omnipred,Prednisolone-21-acetate) is a synthetic corticosteroid drug that is particularly effective as an immunosuppressant agent. |
-
Oncogene, 2024, 43(4):235-247
-
J Immunotoxicol, 2021, 18(1):154-162
-
Eur J Rheumatol, 2021, 10.5152/eurjrheum.2021.20054
|
|
S1733 |
Methylprednisolone
|
Methylprednisolone (NSC-19987,U 7532) is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation. Methylprednisolone activates ACE2 and reduces IL-6 levels, thus improves severe or critical COVID-19. Methylprednisolone markedly reduces autophagy and apoptosis. |
-
Food Chem Toxicol, 2024, 188:114665
-
Drug Test Anal, 2020, 10.1002/dta.2917
-
Nat Med, 2017, 23(4):424-428
|
|
S5685 |
Desoximetasone
|
Desoximetasone (Desoxymethasone, Desoximetasonum) is a synthetic glucocorticoid receptor agonist with metabolic, anti-inflammatory and immunosuppressive activity. |
-
Free Radic Biol Med, 2023, 203:1-10
-
Cell Death Dis, 2022, 13(6):521
-
Autophagy, 2021, 10.1080/15548627.2021.2008692
|
|
S5489 |
Prednisone acetate
|
Prednisone acetate (Betapar, Cortan, Deltasone, Fernisone, Meticorten, Prednisone 21-acetate) is a glucocorticoid steroid that can be used as a glucocorticoid receptor agonist with anti-inflammatory and immunomodulating properties. |
-
Blood Cancer J, 2022, 12(3):36
-
Front Immunol, 2021, 12:739605
-
J Immunotoxicol, 2021, 18(1):154-162
|
|
S4088 |
Flumethasone
|
Flumethasone (RS-2177, NSC-54702,Flumetasone) is a glucocorticoid receptor agonist, this complex binds to the nucleus causing a variety of genetic activation and repressions. |
-
Elife, 2023, 12e82249
-
Drug Test Anal, 2020, 10.1002/dta.2917
|
|
S1701 |
Desonide
|
Desonide is a low potency topical corticosteroid. |
-
Nat Commun, 2022, 13(1):4109
-
Drug Test Anal, 2020, 10.1002/dta.2917
|
|
S5184 |
Dexamethasone palmitate
|
Dexamethasone palmitate (DXP), a lipophilic prodrug of Dexamethasone (DXM), is a glucocorticoid receptor agonist with a 47-fold lower affinity for the glucocorticoid receptor than DXM. Dexamethasone palmitate (DXP) exhibits anti-inflammatory activity. |
-
Dis Model Mech, 2022, dmm.049109
-
Hematology, 2022, 27(1):32-42
|
|
S1888 |
Deflazacort
|
Deflazacort (MDL 458) is a glucocorticoid used as an anti-inflammatory and immunosuppressant. |
-
Drug Test Anal, 2020, 10.1002/dta.2917
|
|
S1500 |
Betamethasone
|
Betamethasone (NSC-39470, SCH-4831) is a glucocorticoid steroid with anti-inflammatory and immunosuppressive properties. |
-
BMC Pharmacol Toxicol, 2024, 25(1):25
-
BMC Pharmacol Toxicol, 2024, 25(1):25
-
Anticancer Drugs, 2022, 10.1097/CAD.0000000000001344
|
|
S2584 |
Clobetasol propionate
|
Clobetasol propionate (CGP9555, CCl 4725) is an anti-inflammatory corticosteroid used to treat various skin disorders. |
-
Exp Ther Med, 2019, 18(2):1258-1266
|
|
S1933 |
Triamcinolone
|
Triamcinolone is a glucocorticoid given, as the free alcohol or in esterified form, orally, intramuscularly, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. |
-
Gastroenterology, 2024, S0016-5085(24)00062-3
-
Drug Test Anal, 2020, 10.1002/dta.2917
|
|
S6608 |
AL082D06
|
AL082D06 is a nonsteroidal glucocorticoid receptor (GR) antagonist with no detectable binding affinity for the highly related receptors for mineralocorticoids, androgens, estrogens, and progestins. |
-
Int J Mol Sci, 2023, 24(14)11700
|
|
S5486 |
Fluorometholone
|
Fluorometholone (Oxylone) is a synthetic glucocorticoid with anti-inflammatory and anti-allergic properties. It is usually used as eye drops in the treatment of allergic and inflammatory conditions of the eye. |
-
Drug Test Anal, 2020, 10.1002/dta.2917
|
|
E1091 |
Relacorilant (CORT125134)
|
Relacorilant (CORT125134) is a potent, selective and orally bioavailable glucocorticoid receptor antagonist, with a Ki of 7.2 nM in HepG2 TAT assay, and also shows Kis of 12, 81.2, 210 nM for rat, human and monkey glucocorticoid receptor in cell-based assay, respectively. |
-
Biomed Pharmacother, 2024, 180:117523
-
J Endocrinol Invest, 2023, 10.1007/s40618-023-02184-3
|
|
S1669 |
Loteprednol etabonate
|
Loteprednol etabonate is a potent glucocorticoid receptor agonist, used in treatment of inflammation of the eye due to allergies. |
|
|
S1987 |
Mometasone furoate
|
Mometasone Furoate (SCH-32088,mometasone 17-furoate) is a glucocorticoid receptor agonist, used topically to reduce inflammation of the skin or in the airways. |
-
J Bone Oncol, 2024, 47:100618
|
|
S1689 |
Meprednisone
|
Meprednisone (NSC 527579, SCH 4358) is a glucocorticoid and a methylated derivative of prednisone. |
|
|
S2470 |
Fluocinolone Acetonide
|
Fluocinolone Acetonide (Flucort-N) is a corticosteroid that binds to the cytosolic glucocorticoid receptor. |
-
Acta Pharm Sin B, 2023, 13(2):662-677
|
|
S1688 |
Betamethasone Dipropionate
|
Betamethasone Dipropionate (SCH 11460) is a glucocorticoid steroid with anti-inflammatory and immunosuppressive abilities. |
-
J Nanobiotechnology, 2024, 22(1):706
|
|
S1690 |
Betamethasone Valerate
|
Betamethasone Valerate is a moderately potent glucocorticoid steroid with anti-inflammatory and immunosuppressive properties. |
|
|
S2608 |
Fluocinonide
|
Fluocinonide (Vanos,nsc 101791) is a potent glucocorticoid steroid used topically as anti-inflammatory agent for the treatment of skin disorders such as eczema. |
|
|
S3078 |
Beclomethasone dipropionate
|
Beclomethasone dipropionate(Beclometasone dipropionate,Beclovent,Beconase,Vancenase) is a potent glucocorticoid steroid used for the treatment of rhinitis and sinusitis. |
|
|
S3617 |
(20S)-Protopanaxatriol
|
(20S)-Protopanaxatriol (g-PPT, 20(S)-APPT), a neuroprotective metabolite of ginsenoside, protopanaxatriol (g-PPT), is a functional ligand for both GR and ERbeta and could modulate endothelial cell functions through the glucocorticoid receptor (GR) and estrogen receptor (ER).
|
|
|
S5973 |
Methylprednisolone Acetate
|
Methylprednisolone (NSC-19987, Medrol) acetate is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation. Methylprednisolone activates ACE2 and reduces IL-6 levels, thus improves severe or critical COVID-19. Methylprednisolone markedly reduces autophagy and apoptosis. |
|
|
S4752 |
Corticosterone
|
Corticosterone, the major stress hormone, is an adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. |
-
Gen Psychiatr, 2024, 37(1):e101291
-
Biomater Res, 2024, 28:0010
-
Front Endocrinol -Lausanne), 2022, 13:951928
|
|
S4228 |
Fluorometholone Acetate
|
Fluorometholone Acetate (NSC 47438,Oxylone acetate) is a synthetic corticosteroid, used in the treatment of steroid responsive inflammatory conditions of the eye. |
|
|
E4918New |
BecloMethasone
|
Beclomethasone(Beclometasone) is a prototype agonist of glucocorticoid receptor. Beclomethasone and its derivatives display have higher binding affinity to glucocorticoid receptors in rat liver, thymus, and hypophysis. |
|
|
S4775 |
Cortodoxone
|
Cortodoxone (11-Deoxycortisol, cortexolone, 11-Desoxycortisol, 17α,21-dihydroxyprogesterone), also known as 11-Deoxycortisol, is a glucocorticoid steroid hormone. |
|
|
E0177 |
Hydrocortisone sodium succinate
|
Hydrocortisone sodium succinate (Hydrocortisone 21-hemisuccinate sodium salt) has significant inhibitory effects on the IL-6 bioactivity with IC50 of 6.7 μM. Hydrocortisone sodium succinate can bind to glucocorticoid receptor, initiating the transcription of anti-inflammatory and immunosuppressive mediators. |
|
|
S4028 |
Dexamethasone Sodium Phosphate
|
Dexamethasone (Dexamethasone 21-phosphate disodium salt) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects. |
-
Cancer Cell, 2024, 42(9):1507-1527.e11
-
Pharmaceutics, 2022, 14(2)400
-
Front Oncol, 2022, 12:888695
|
|
S1696 |
Hydrocortisone
|
Hydrocortisone is a steroid hormone or glucocorticoid produced by the adrenal gland. |
-
Int J Radiat Oncol Biol Phys, 2024, S0360-3016(24)00307-9
-
Cells, 2024, 13(14)1224
-
Neurobiol Stress, 2024, 28:100593
|
|
S1737 |
Prednisolone
|
Prednisolone is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. |
-
Molecules, 2024, 29(7)1546
-
Life Sci Alliance, 2023, 6(10)e202302009
-
Life Sci Alliance, 2023, 6(10)e202302009
|
|
S5956 |
Dexamethasone phosphate disodium
|
Dexamethasone phosphate disodium is a glucocorticoid receptor agonist with both anti-inflammatory and anti-oxidative effects. |
-
Cell Rep, 2023, 42(6):112566
-
Blood Adv, 2023, 7(4):469-481
-
Heliyon, 2023, 9(3):e14006
|
|
S2559 |
Cortisone acetate
|
Cortisone acetate (Cortone, NSC 49420) is an acetate salt form of cortisone that is a steroid hormone and a glucocorticoid. |
-
J Pers Med, 2022, 12(2)258
-
Hum Cell, 2022, 10.1007/s13577-022-00671-y
-
Hum Cell, 2021, 34(6):1911-1918
|
|
S1622 |
Prednisone
|
Prednisone is a synthetic corticosteroid agent that is particularly effective as an immunosuppressant compound. |
-
Blood Cancer J, 2022, 12(3):36
-
Int J Mol Sci, 2022, 23(7)3834
-
Front Immunol, 2021, 12:739605
|
|
S1286 |
Budesonide
|
Budesonide(Labazenit) is a glucocorticoid steroid for the treatment of asthma, non-infectious rhinitis. |
-
Front Mol Neurosci, 2024, 17:1473960
-
Front Immunol, 2023, 14:1097383
-
Front Immunol, 2023, 14:1097383
|
|
S4646 |
Ciclesonide
|
Ciclesonide (Alvesco, Omnaris, RPR251526, Zetonna) is a glucocorticoid used to treat obstructive airway diseases. |
-
Acta Pharm Sin B, 2023, 13(2):662-677
-
Am J Physiol Lung Cell Mol Physiol, 2023, 324(5):L722-L736
-
mBio, 2022, 13(1):e0304421
|
|
S1992 |
Fluticasone propionate
|
Fluticasone Propionate (CCI-187881) is a synthetic glucocorticoid, used to treat non-allergic and allergic rhinitis. |
-
Heliyon, 2024, 10(20):e39475
-
Cell Rep Methods, 2023, 3(4):100440
-
Cell Rep Methods, 2023, 3(4):100440
|
|
S1628 |
Triamcinolone Acetonide
|
Triamcinolone acetonide is a synthetic glucocorticoid, used in the symptomatic treatment of inflammation. |
-
J Transl Med, 2022, 20(1):561
-
J Inflamm Res, 2021, 14:843-858
-
Theranostics, 2020, 10(1):247-264
|
|
S2570 |
Prednisolone Acetate
|
Prednisolone Acetate (Omnipred,Prednisolone-21-acetate) is a synthetic corticosteroid drug that is particularly effective as an immunosuppressant agent. |
-
Oncogene, 2024, 43(4):235-247
-
J Immunotoxicol, 2021, 18(1):154-162
-
Eur J Rheumatol, 2021, 10.5152/eurjrheum.2021.20054
|
|
S1733 |
Methylprednisolone
|
Methylprednisolone (NSC-19987,U 7532) is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation. Methylprednisolone activates ACE2 and reduces IL-6 levels, thus improves severe or critical COVID-19. Methylprednisolone markedly reduces autophagy and apoptosis. |
-
Food Chem Toxicol, 2024, 188:114665
-
Drug Test Anal, 2020, 10.1002/dta.2917
-
Nat Med, 2017, 23(4):424-428
|
|
S5685 |
Desoximetasone
|
Desoximetasone (Desoxymethasone, Desoximetasonum) is a synthetic glucocorticoid receptor agonist with metabolic, anti-inflammatory and immunosuppressive activity. |
-
Free Radic Biol Med, 2023, 203:1-10
-
Cell Death Dis, 2022, 13(6):521
-
Autophagy, 2021, 10.1080/15548627.2021.2008692
|
|
S5489 |
Prednisone acetate
|
Prednisone acetate (Betapar, Cortan, Deltasone, Fernisone, Meticorten, Prednisone 21-acetate) is a glucocorticoid steroid that can be used as a glucocorticoid receptor agonist with anti-inflammatory and immunomodulating properties. |
-
Blood Cancer J, 2022, 12(3):36
-
Front Immunol, 2021, 12:739605
-
J Immunotoxicol, 2021, 18(1):154-162
|
|
S4088 |
Flumethasone
|
Flumethasone (RS-2177, NSC-54702,Flumetasone) is a glucocorticoid receptor agonist, this complex binds to the nucleus causing a variety of genetic activation and repressions. |
-
Elife, 2023, 12e82249
-
Drug Test Anal, 2020, 10.1002/dta.2917
|
|
S1701 |
Desonide
|
Desonide is a low potency topical corticosteroid. |
-
Nat Commun, 2022, 13(1):4109
-
Drug Test Anal, 2020, 10.1002/dta.2917
|
|
S5184 |
Dexamethasone palmitate
|
Dexamethasone palmitate (DXP), a lipophilic prodrug of Dexamethasone (DXM), is a glucocorticoid receptor agonist with a 47-fold lower affinity for the glucocorticoid receptor than DXM. Dexamethasone palmitate (DXP) exhibits anti-inflammatory activity. |
-
Dis Model Mech, 2022, dmm.049109
-
Hematology, 2022, 27(1):32-42
|
|
S1888 |
Deflazacort
|
Deflazacort (MDL 458) is a glucocorticoid used as an anti-inflammatory and immunosuppressant. |
-
Drug Test Anal, 2020, 10.1002/dta.2917
|
|
S1500 |
Betamethasone
|
Betamethasone (NSC-39470, SCH-4831) is a glucocorticoid steroid with anti-inflammatory and immunosuppressive properties. |
-
BMC Pharmacol Toxicol, 2024, 25(1):25
-
BMC Pharmacol Toxicol, 2024, 25(1):25
-
Anticancer Drugs, 2022, 10.1097/CAD.0000000000001344
|
|
S2584 |
Clobetasol propionate
|
Clobetasol propionate (CGP9555, CCl 4725) is an anti-inflammatory corticosteroid used to treat various skin disorders. |
-
Exp Ther Med, 2019, 18(2):1258-1266
|
|
S1933 |
Triamcinolone
|
Triamcinolone is a glucocorticoid given, as the free alcohol or in esterified form, orally, intramuscularly, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. |
-
Gastroenterology, 2024, S0016-5085(24)00062-3
-
Drug Test Anal, 2020, 10.1002/dta.2917
|
|
S5486 |
Fluorometholone
|
Fluorometholone (Oxylone) is a synthetic glucocorticoid with anti-inflammatory and anti-allergic properties. It is usually used as eye drops in the treatment of allergic and inflammatory conditions of the eye. |
-
Drug Test Anal, 2020, 10.1002/dta.2917
|
|
S1669 |
Loteprednol etabonate
|
Loteprednol etabonate is a potent glucocorticoid receptor agonist, used in treatment of inflammation of the eye due to allergies. |
|
|
S1987 |
Mometasone furoate
|
Mometasone Furoate (SCH-32088,mometasone 17-furoate) is a glucocorticoid receptor agonist, used topically to reduce inflammation of the skin or in the airways. |
-
J Bone Oncol, 2024, 47:100618
|
|
S1689 |
Meprednisone
|
Meprednisone (NSC 527579, SCH 4358) is a glucocorticoid and a methylated derivative of prednisone. |
|
|
S2470 |
Fluocinolone Acetonide
|
Fluocinolone Acetonide (Flucort-N) is a corticosteroid that binds to the cytosolic glucocorticoid receptor. |
-
Acta Pharm Sin B, 2023, 13(2):662-677
|
|
S1688 |
Betamethasone Dipropionate
|
Betamethasone Dipropionate (SCH 11460) is a glucocorticoid steroid with anti-inflammatory and immunosuppressive abilities. |
-
J Nanobiotechnology, 2024, 22(1):706
|
|
S1690 |
Betamethasone Valerate
|
Betamethasone Valerate is a moderately potent glucocorticoid steroid with anti-inflammatory and immunosuppressive properties. |
|
|
S2608 |
Fluocinonide
|
Fluocinonide (Vanos,nsc 101791) is a potent glucocorticoid steroid used topically as anti-inflammatory agent for the treatment of skin disorders such as eczema. |
|
|
S3078 |
Beclomethasone dipropionate
|
Beclomethasone dipropionate(Beclometasone dipropionate,Beclovent,Beconase,Vancenase) is a potent glucocorticoid steroid used for the treatment of rhinitis and sinusitis. |
|
|
S3617 |
(20S)-Protopanaxatriol
|
(20S)-Protopanaxatriol (g-PPT, 20(S)-APPT), a neuroprotective metabolite of ginsenoside, protopanaxatriol (g-PPT), is a functional ligand for both GR and ERbeta and could modulate endothelial cell functions through the glucocorticoid receptor (GR) and estrogen receptor (ER).
|
|
|
S5973 |
Methylprednisolone Acetate
|
Methylprednisolone (NSC-19987, Medrol) acetate is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation. Methylprednisolone activates ACE2 and reduces IL-6 levels, thus improves severe or critical COVID-19. Methylprednisolone markedly reduces autophagy and apoptosis. |
|
|
S4752 |
Corticosterone
|
Corticosterone, the major stress hormone, is an adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. |
-
Gen Psychiatr, 2024, 37(1):e101291
-
Biomater Res, 2024, 28:0010
-
Front Endocrinol -Lausanne), 2022, 13:951928
|
|
S4228 |
Fluorometholone Acetate
|
Fluorometholone Acetate (NSC 47438,Oxylone acetate) is a synthetic corticosteroid, used in the treatment of steroid responsive inflammatory conditions of the eye. |
|
|
E4918New |
BecloMethasone
|
Beclomethasone(Beclometasone) is a prototype agonist of glucocorticoid receptor. Beclomethasone and its derivatives display have higher binding affinity to glucocorticoid receptors in rat liver, thymus, and hypophysis. |
|
|
S4775 |
Cortodoxone
|
Cortodoxone (11-Deoxycortisol, cortexolone, 11-Desoxycortisol, 17α,21-dihydroxyprogesterone), also known as 11-Deoxycortisol, is a glucocorticoid steroid hormone. |
|
|
S4028 |
Dexamethasone Sodium Phosphate
|
Dexamethasone (Dexamethasone 21-phosphate disodium salt) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects. |
- Cancer Cell, 2024, 42(9):1507-1527.e11
- Pharmaceutics, 2022, 14(2)400
- Front Oncol, 2022, 12:888695
|
|
S1696 |
Hydrocortisone
|
Hydrocortisone is a steroid hormone or glucocorticoid produced by the adrenal gland. |
- Int J Radiat Oncol Biol Phys, 2024, S0360-3016(24)00307-9
- Cells, 2024, 13(14)1224
- Neurobiol Stress, 2024, 28:100593
|
|
S1737 |
Prednisolone
|
Prednisolone is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. |
- Molecules, 2024, 29(7)1546
- Life Sci Alliance, 2023, 6(10)e202302009
- Life Sci Alliance, 2023, 6(10)e202302009
|
|
S5956 |
Dexamethasone phosphate disodium
|
Dexamethasone phosphate disodium is a glucocorticoid receptor agonist with both anti-inflammatory and anti-oxidative effects. |
- Cell Rep, 2023, 42(6):112566
- Blood Adv, 2023, 7(4):469-481
- Heliyon, 2023, 9(3):e14006
|
|
S2559 |
Cortisone acetate
|
Cortisone acetate (Cortone, NSC 49420) is an acetate salt form of cortisone that is a steroid hormone and a glucocorticoid. |
- J Pers Med, 2022, 12(2)258
- Hum Cell, 2022, 10.1007/s13577-022-00671-y
- Hum Cell, 2021, 34(6):1911-1918
|
|
S1622 |
Prednisone
|
Prednisone is a synthetic corticosteroid agent that is particularly effective as an immunosuppressant compound. |
- Blood Cancer J, 2022, 12(3):36
- Int J Mol Sci, 2022, 23(7)3834
- Front Immunol, 2021, 12:739605
|
|
S1286 |
Budesonide
|
Budesonide(Labazenit) is a glucocorticoid steroid for the treatment of asthma, non-infectious rhinitis. |
- Front Mol Neurosci, 2024, 17:1473960
- Front Immunol, 2023, 14:1097383
- Front Immunol, 2023, 14:1097383
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S4646 |
Ciclesonide
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Ciclesonide (Alvesco, Omnaris, RPR251526, Zetonna) is a glucocorticoid used to treat obstructive airway diseases. |
- Acta Pharm Sin B, 2023, 13(2):662-677
- Am J Physiol Lung Cell Mol Physiol, 2023, 324(5):L722-L736
- mBio, 2022, 13(1):e0304421
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S1992 |
Fluticasone propionate
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Fluticasone Propionate (CCI-187881) is a synthetic glucocorticoid, used to treat non-allergic and allergic rhinitis. |
- Heliyon, 2024, 10(20):e39475
- Cell Rep Methods, 2023, 3(4):100440
- Cell Rep Methods, 2023, 3(4):100440
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S1628 |
Triamcinolone Acetonide
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Triamcinolone acetonide is a synthetic glucocorticoid, used in the symptomatic treatment of inflammation. |
- J Transl Med, 2022, 20(1):561
- J Inflamm Res, 2021, 14:843-858
- Theranostics, 2020, 10(1):247-264
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S2570 |
Prednisolone Acetate
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Prednisolone Acetate (Omnipred,Prednisolone-21-acetate) is a synthetic corticosteroid drug that is particularly effective as an immunosuppressant agent. |
- Oncogene, 2024, 43(4):235-247
- J Immunotoxicol, 2021, 18(1):154-162
- Eur J Rheumatol, 2021, 10.5152/eurjrheum.2021.20054
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S1733 |
Methylprednisolone
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Methylprednisolone (NSC-19987,U 7532) is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation. Methylprednisolone activates ACE2 and reduces IL-6 levels, thus improves severe or critical COVID-19. Methylprednisolone markedly reduces autophagy and apoptosis. |
- Food Chem Toxicol, 2024, 188:114665
- Drug Test Anal, 2020, 10.1002/dta.2917
- Nat Med, 2017, 23(4):424-428
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S5685 |
Desoximetasone
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Desoximetasone (Desoxymethasone, Desoximetasonum) is a synthetic glucocorticoid receptor agonist with metabolic, anti-inflammatory and immunosuppressive activity. |
- Free Radic Biol Med, 2023, 203:1-10
- Cell Death Dis, 2022, 13(6):521
- Autophagy, 2021, 10.1080/15548627.2021.2008692
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S5489 |
Prednisone acetate
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Prednisone acetate (Betapar, Cortan, Deltasone, Fernisone, Meticorten, Prednisone 21-acetate) is a glucocorticoid steroid that can be used as a glucocorticoid receptor agonist with anti-inflammatory and immunomodulating properties. |
- Blood Cancer J, 2022, 12(3):36
- Front Immunol, 2021, 12:739605
- J Immunotoxicol, 2021, 18(1):154-162
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S4088 |
Flumethasone
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Flumethasone (RS-2177, NSC-54702,Flumetasone) is a glucocorticoid receptor agonist, this complex binds to the nucleus causing a variety of genetic activation and repressions. |
- Elife, 2023, 12e82249
- Drug Test Anal, 2020, 10.1002/dta.2917
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S1701 |
Desonide
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Desonide is a low potency topical corticosteroid. |
- Nat Commun, 2022, 13(1):4109
- Drug Test Anal, 2020, 10.1002/dta.2917
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S5184 |
Dexamethasone palmitate
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Dexamethasone palmitate (DXP), a lipophilic prodrug of Dexamethasone (DXM), is a glucocorticoid receptor agonist with a 47-fold lower affinity for the glucocorticoid receptor than DXM. Dexamethasone palmitate (DXP) exhibits anti-inflammatory activity. |
- Dis Model Mech, 2022, dmm.049109
- Hematology, 2022, 27(1):32-42
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S1888 |
Deflazacort
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Deflazacort (MDL 458) is a glucocorticoid used as an anti-inflammatory and immunosuppressant. |
- Drug Test Anal, 2020, 10.1002/dta.2917
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S1500 |
Betamethasone
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Betamethasone (NSC-39470, SCH-4831) is a glucocorticoid steroid with anti-inflammatory and immunosuppressive properties. |
- BMC Pharmacol Toxicol, 2024, 25(1):25
- BMC Pharmacol Toxicol, 2024, 25(1):25
- Anticancer Drugs, 2022, 10.1097/CAD.0000000000001344
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S2584 |
Clobetasol propionate
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Clobetasol propionate (CGP9555, CCl 4725) is an anti-inflammatory corticosteroid used to treat various skin disorders. |
- Exp Ther Med, 2019, 18(2):1258-1266
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S1933 |
Triamcinolone
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Triamcinolone is a glucocorticoid given, as the free alcohol or in esterified form, orally, intramuscularly, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. |
- Gastroenterology, 2024, S0016-5085(24)00062-3
- Drug Test Anal, 2020, 10.1002/dta.2917
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S5486 |
Fluorometholone
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Fluorometholone (Oxylone) is a synthetic glucocorticoid with anti-inflammatory and anti-allergic properties. It is usually used as eye drops in the treatment of allergic and inflammatory conditions of the eye. |
- Drug Test Anal, 2020, 10.1002/dta.2917
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S1669 |
Loteprednol etabonate
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Loteprednol etabonate is a potent glucocorticoid receptor agonist, used in treatment of inflammation of the eye due to allergies. |
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S1987 |
Mometasone furoate
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Mometasone Furoate (SCH-32088,mometasone 17-furoate) is a glucocorticoid receptor agonist, used topically to reduce inflammation of the skin or in the airways. |
- J Bone Oncol, 2024, 47:100618
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S1689 |
Meprednisone
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Meprednisone (NSC 527579, SCH 4358) is a glucocorticoid and a methylated derivative of prednisone. |
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S2470 |
Fluocinolone Acetonide
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Fluocinolone Acetonide (Flucort-N) is a corticosteroid that binds to the cytosolic glucocorticoid receptor. |
- Acta Pharm Sin B, 2023, 13(2):662-677
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S1688 |
Betamethasone Dipropionate
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Betamethasone Dipropionate (SCH 11460) is a glucocorticoid steroid with anti-inflammatory and immunosuppressive abilities. |
- J Nanobiotechnology, 2024, 22(1):706
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S1690 |
Betamethasone Valerate
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Betamethasone Valerate is a moderately potent glucocorticoid steroid with anti-inflammatory and immunosuppressive properties. |
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S2608 |
Fluocinonide
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Fluocinonide (Vanos,nsc 101791) is a potent glucocorticoid steroid used topically as anti-inflammatory agent for the treatment of skin disorders such as eczema. |
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S3078 |
Beclomethasone dipropionate
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Beclomethasone dipropionate(Beclometasone dipropionate,Beclovent,Beconase,Vancenase) is a potent glucocorticoid steroid used for the treatment of rhinitis and sinusitis. |
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S3617 |
(20S)-Protopanaxatriol
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(20S)-Protopanaxatriol (g-PPT, 20(S)-APPT), a neuroprotective metabolite of ginsenoside, protopanaxatriol (g-PPT), is a functional ligand for both GR and ERbeta and could modulate endothelial cell functions through the glucocorticoid receptor (GR) and estrogen receptor (ER).
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S5973 |
Methylprednisolone Acetate
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Methylprednisolone (NSC-19987, Medrol) acetate is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation. Methylprednisolone activates ACE2 and reduces IL-6 levels, thus improves severe or critical COVID-19. Methylprednisolone markedly reduces autophagy and apoptosis. |
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S4752 |
Corticosterone
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Corticosterone, the major stress hormone, is an adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. |
- Gen Psychiatr, 2024, 37(1):e101291
- Biomater Res, 2024, 28:0010
- Front Endocrinol -Lausanne), 2022, 13:951928
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S4228 |
Fluorometholone Acetate
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Fluorometholone Acetate (NSC 47438,Oxylone acetate) is a synthetic corticosteroid, used in the treatment of steroid responsive inflammatory conditions of the eye. |
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E4918New |
BecloMethasone
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Beclomethasone(Beclometasone) is a prototype agonist of glucocorticoid receptor. Beclomethasone and its derivatives display have higher binding affinity to glucocorticoid receptors in rat liver, thymus, and hypophysis. |
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S4775 |
Cortodoxone
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Cortodoxone (11-Deoxycortisol, cortexolone, 11-Desoxycortisol, 17α,21-dihydroxyprogesterone), also known as 11-Deoxycortisol, is a glucocorticoid steroid hormone. |
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