Adenosine Receptor

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Adenosine Receptor製品

• All (38)
• Adenosine Receptor阻害剤 (2)
• Adenosine Receptor拮抗剤(17)
• Adenosine Receptor作動薬(9)
• Adenosine Receptorモジュレータ(1)
• 新製品

製品コード	製品名称	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S2153	CGS 21680 HCl	CGS 21680 HCl is an adenosine A2 receptor agonist with IC50 of 22 nM, exhibits 140-fold over A1 receptor.	Clin Immunol, 2024, 266:110309 CNS Neurosci Ther, 2024, 30(5):e14726 Cell Rep Med, 2023, 4(9):101188
S7588	Reversine	Reversine is a potent human A3 adenosine receptor antagonist with Ki of 0.66 μM, and a pan-aurora A/B/C kinase inhibitor with IC50 of 400 nM/500 nM/400 nM, respectively. Also used for stem cell dedifferentiation.	Nat Commun, 2023, 14(1):3364 Commun Biol, 2023, 6(1):1271 Heliyon, 2023, 9(9):e20182
S1647	Adenosine	Adenosine is a nucleoside composed of a molecule of adenine attached to a ribose sugar molecule (ribofuranose) moiety via a β-N9-glycosidic bond.	Nat Commun, 2022, 13(1):5845 Cancer Res, 2022, canres.1707.2021 Immunology, 2022, 10.1111/imm.13493
S8105	ZM241385	ZM-241385 is a high affinity antagonist ligand selective for the adenosine A2A receptor.	Front Cell Dev Biol, 2022, 10:827714 Mol Biol Rep, 2021, 10.1007/s11033-021-07017-1 Cell Mol Immunol, 2020, 10
S8104	SCH58261	SCH 58261 is a potent and selective A2a adenosine receptor antagonist with Ki of 2.3 nM and 2 nM for rat A2a and bovine A2a, respectively.	CNS Neurosci Ther, 2024, 30(5):e14726 Molecules, 2022, 27(19)6267 J Neurochem, 2021, 10.1111/jnc.15436
S2790	Istradefylline	Istradefylline (KW-6002) is a selective adenosine A2A receptor (A2AR) antagonist with Ki of 2.2 nM. Phase 3.	Nat Commun, 2023, 14(1):3364 Immunology, 2022, 10.1111/imm.13493 Sci Rep, 2022, 12(1):4183
S8575	A2AR antagonist 1	A2AR antagonist 1 is a potent A2AR (Adenosine A2A Receptor) antagonist with Ki values of 4 nM and 264 nM for A2AR and A1R, respectively.	MedComm (2020), 2023, 4(2):e242 MedComm (2020), 2023, 4(2):e242 Mol Cancer Res, 2019, 17(5):1166-1179
S6646	Ciforadenant (CPI-444)	Ciforadenant (CPI-444, V81444) is a potent and selective Adenosine A2A receptor antagonist. It binds to A2A receptors with a Ki of 3.54 nmol/L and demonstrates a greater than 50-fold selectivity for the A2A receptor over other adenosine receptor subtypes.	Cancer Immunol Immunother, 2024, 73(6):108 Cell Mol Gastroenterol Hepatol, 2022, S2352-345X(22)00163-1
S8720	Imaradenant (AZD4635)	Imaradenant (AZD4635, HTL1071) is an oral A2AR antagonist that binds to human A2AR with a Ki of 1.7 nM and with > 30-fold selectivity over other adenosine receptors.	Front Immunol, 2021, 12:687296
S5358	Regadenoson	Regadenoson (CVT-3146, Lexiscan) is a selective A2A adenosine receptor agonist with coronary vasodilating activity.
S0498	Namodenoson (CF-102)	Namodenoson (CF-102, 2-Cl-IB-MECA) is an orally bioavailable and selective agonist of the A3 adenosine receptor (A3AR) with Ki of 0.33 nM. Namodenoson exerts an anti‑NASH effect mediated via the de‑regulation of the PI3K/NF‑κB/Wnt/β‑catenin signaling pathway.
E4032	5'-Deoxy-5'-(methylthio)adenosine	5'-Deoxy-5'-(methylthio)adenosine (Methylthioadenosine, MTA) is a naturally occurring sulfur-containing nucleoside produced by the decarboxylation of S-adenosylmethionine. This nucleoside is a potent agonist of adenosine receptors with Ki of 0.15, 1.13, 13.9, and 0.68 μM for A1, A2A, A2B, and A3, respectively.
S0721	Ticlopidine	Ticlopidine (Yuclid, Ticlopidinum, Ticlopidina,PCR 5332) is an orally active inhibitor of platelet aggregation induced by adenosine diphosphate (ADP). Ticlopidine is also an inhibitor of CYP2B6 with Ki of 0.2 μM.
S0272	Derenofylline (SLV320)	Derenofylline (SLV320) is a selective and potent adenosine A1 antagonist with Ki of 1 nM. Derenofylline shows selective for adenosine A1 over A2A, A2B, and A3 receptors with Ki of 398 nM, 3981 nM, and 200 nM, respectively.
S4932	Proxyphylline	Proxyphylline (Monophylline, Spasmolysin) is a derivative of theophylline which is used as a bronchodilator and for its cardiovascular properties. It selectively antagonizes A1 adenosine receptors (Ki = 82 nM for bovine brain) versus A2 adenosine receptors (Ki = 850 µM for platelets).
E2985	Capadenoson	Capadenoson (BAY 68-4986) is an orally bioavailable, non-nucleoside partial adenosine A1 receptor agonist that exhibits an anti-ischemic effect.
E4450	N6-Cyclopentyladenosine	N6-Cyclopentyladenosine is an adenosine derivative and a potent adenosine receptor agonist with Ki values of 2.3 nM, 790 nM and 43 nM for human A1, A2A and A3 receptors, respectively. It acts as an anticonvulsant and might exhibit protective actions against aminophylline (AMPH)-induced seizures.
E0356	MIPS521	MIPS521 is a positive allosteric modulator of the A1R that exhibits analgesic efficacy in rats in vivo.
S5678	trans-Zeatin-riboside	Zeatin Riboside 是天然的细胞分裂素中最活跃和最普遍的形式，可促进细胞分裂，刺激芽增殖，抑制根形成，减缓衰老过程并激活基因表达和代谢活性。Zeatin Riboside 通过激动哺乳动物的 adenosine A2A receptor 起到免疫调节作用。
E1310	DPCPX	DPCPX (PD 116948), a xanthine derivative, is a highly potent and selective adenosine A1 receptor (ADORA1) antagonist, with a Ki of 0.46 nM.	Cell Biol Toxicol, 2024, 40(1):59
E4632New	Taminadenant	Taminadenant (NIR178, PBF509) is a non-xanthine and non-furan antagonist of adenosine A2A receptor (A2AR). It can antagonize A2AR agonist-mediated cAMP accumulation and impedance responses with Kb values of 72.8 nM and 8.2 nM, respectively. It exhibits potential utility for Parkinson’s disease (PD) treatment.
S6639	BAY-545	BAY-545 is an A2B adenosine receptor antagonist with ic50 of 59 nM.
S6910	Preladenant	Preladenant (Privadenant, SCH 420814, MK-3814) is a potent, competitive and selective antagonist of the human adenosine A2A receptor with Ki of 1.1 nM.
S9608	Etrumadenant (AB928)	Etrumadenant (AB928, A2aR/A2bR antagonist-1) is a novel dual A2aR/A2bR antagonist with Kd of 1.4 nM and 2 nM for A2aR and A2bR, respectively.	Natural Product Communications, 2022, 2022;17(10)
S0838	NBMPR (S-(4-Nitrobenzyl)-6-thioinosine)	NBMPR (S-(4-Nitrobenzyl)-6-thioinosine) is an inhibitor of ENT1 transporter that crosses the blood-brain barrier and is able to potentiate the neuroprotective effects of adenosine.
S2945	SCH-442416	SCH-442416 is a selective antagonist of adenosine A2A receptor that binds to human and rat adenosine A2A receptors with Ki of 0.048 nM and 0.5 nM, respectively.
S6347	5'-N-Ethylcarboxamidoadenosine (NECA)	5'-N-Ethylcarboxamidoadenosine (NECA, 5'-(N-Ethylcarboxamido)adenosine, Adenosine-5'N-ethylcarboxamide, 5'-Ethylcarboxamidoadenosine) is a stable, nonselective adenosine receptor agonist. 5'-N-Ethylcarboxamidoadenosine acts via multiple mechanisms including: reducing diabetes-induced oxidative stress, inhibiting gene expression of IL-18, TNF-α and ICAM-1 (intercellular adhesion molecule 1 (CD54)), and blocking activation of the JNK-MAPK pathway.
S5427	Alloxazine	Alloxazine (Isoalloxazine) is an A2 receptor antagonist, which is approximately 10-fold more selective for the A2B receptor than for the A2A receptor.
S3988	Theophylline-7-acetic acid	Theophylline-7-acetic acid (Acefylline, acetyloxytheophylline, Carboxymethyltheophylline), acting as an adenosine receptor antagonist, is a stimulant drug of the xanthine chemical class.
S2153	CGS 21680 HCl	CGS 21680 HCl is an adenosine A2 receptor agonist with IC50 of 22 nM, exhibits 140-fold over A1 receptor.	Clin Immunol, 2024, 266:110309 CNS Neurosci Ther, 2024, 30(5):e14726 Cell Rep Med, 2023, 4(9):101188
S1647	Adenosine	Adenosine is a nucleoside composed of a molecule of adenine attached to a ribose sugar molecule (ribofuranose) moiety via a β-N9-glycosidic bond.	Nat Commun, 2022, 13(1):5845 Cancer Res, 2022, canres.1707.2021 Immunology, 2022, 10.1111/imm.13493
S5358	Regadenoson	Regadenoson (CVT-3146, Lexiscan) is a selective A2A adenosine receptor agonist with coronary vasodilating activity.
S0498	Namodenoson (CF-102)	Namodenoson (CF-102, 2-Cl-IB-MECA) is an orally bioavailable and selective agonist of the A3 adenosine receptor (A3AR) with Ki of 0.33 nM. Namodenoson exerts an anti‑NASH effect mediated via the de‑regulation of the PI3K/NF‑κB/Wnt/β‑catenin signaling pathway.
E4032	5'-Deoxy-5'-(methylthio)adenosine	5'-Deoxy-5'-(methylthio)adenosine (Methylthioadenosine, MTA) is a naturally occurring sulfur-containing nucleoside produced by the decarboxylation of S-adenosylmethionine. This nucleoside is a potent agonist of adenosine receptors with Ki of 0.15, 1.13, 13.9, and 0.68 μM for A1, A2A, A2B, and A3, respectively.
E2985	Capadenoson	Capadenoson (BAY 68-4986) is an orally bioavailable, non-nucleoside partial adenosine A1 receptor agonist that exhibits an anti-ischemic effect.
E4450	N6-Cyclopentyladenosine	N6-Cyclopentyladenosine is an adenosine derivative and a potent adenosine receptor agonist with Ki values of 2.3 nM, 790 nM and 43 nM for human A1, A2A and A3 receptors, respectively. It acts as an anticonvulsant and might exhibit protective actions against aminophylline (AMPH)-induced seizures.
S5678	trans-Zeatin-riboside	Zeatin Riboside 是天然的细胞分裂素中最活跃和最普遍的形式，可促进细胞分裂，刺激芽增殖，抑制根形成，减缓衰老过程并激活基因表达和代谢活性。Zeatin Riboside 通过激动哺乳动物的 adenosine A2A receptor 起到免疫调节作用。
S6347	5'-N-Ethylcarboxamidoadenosine (NECA)	5'-N-Ethylcarboxamidoadenosine (NECA, 5'-(N-Ethylcarboxamido)adenosine, Adenosine-5'N-ethylcarboxamide, 5'-Ethylcarboxamidoadenosine) is a stable, nonselective adenosine receptor agonist. 5'-N-Ethylcarboxamidoadenosine acts via multiple mechanisms including: reducing diabetes-induced oxidative stress, inhibiting gene expression of IL-18, TNF-α and ICAM-1 (intercellular adhesion molecule 1 (CD54)), and blocking activation of the JNK-MAPK pathway.
S0721	Ticlopidine	Ticlopidine (Yuclid, Ticlopidinum, Ticlopidina,PCR 5332) is an orally active inhibitor of platelet aggregation induced by adenosine diphosphate (ADP). Ticlopidine is also an inhibitor of CYP2B6 with Ki of 0.2 μM.
S0838	NBMPR (S-(4-Nitrobenzyl)-6-thioinosine)	NBMPR (S-(4-Nitrobenzyl)-6-thioinosine) is an inhibitor of ENT1 transporter that crosses the blood-brain barrier and is able to potentiate the neuroprotective effects of adenosine.
S7588	Reversine	Reversine is a potent human A3 adenosine receptor antagonist with Ki of 0.66 μM, and a pan-aurora A/B/C kinase inhibitor with IC50 of 400 nM/500 nM/400 nM, respectively. Also used for stem cell dedifferentiation.	Nat Commun, 2023, 14(1):3364 Commun Biol, 2023, 6(1):1271 Heliyon, 2023, 9(9):e20182
S8105	ZM241385	ZM-241385 is a high affinity antagonist ligand selective for the adenosine A2A receptor.	Front Cell Dev Biol, 2022, 10:827714 Mol Biol Rep, 2021, 10.1007/s11033-021-07017-1 Cell Mol Immunol, 2020, 10
S8104	SCH58261	SCH 58261 is a potent and selective A2a adenosine receptor antagonist with Ki of 2.3 nM and 2 nM for rat A2a and bovine A2a, respectively.	CNS Neurosci Ther, 2024, 30(5):e14726 Molecules, 2022, 27(19)6267 J Neurochem, 2021, 10.1111/jnc.15436
S2790	Istradefylline	Istradefylline (KW-6002) is a selective adenosine A2A receptor (A2AR) antagonist with Ki of 2.2 nM. Phase 3.	Nat Commun, 2023, 14(1):3364 Immunology, 2022, 10.1111/imm.13493 Sci Rep, 2022, 12(1):4183
S8575	A2AR antagonist 1	A2AR antagonist 1 is a potent A2AR (Adenosine A2A Receptor) antagonist with Ki values of 4 nM and 264 nM for A2AR and A1R, respectively.	MedComm (2020), 2023, 4(2):e242 MedComm (2020), 2023, 4(2):e242 Mol Cancer Res, 2019, 17(5):1166-1179
S6646	Ciforadenant (CPI-444)	Ciforadenant (CPI-444, V81444) is a potent and selective Adenosine A2A receptor antagonist. It binds to A2A receptors with a Ki of 3.54 nmol/L and demonstrates a greater than 50-fold selectivity for the A2A receptor over other adenosine receptor subtypes.	Cancer Immunol Immunother, 2024, 73(6):108 Cell Mol Gastroenterol Hepatol, 2022, S2352-345X(22)00163-1
S8720	Imaradenant (AZD4635)	Imaradenant (AZD4635, HTL1071) is an oral A2AR antagonist that binds to human A2AR with a Ki of 1.7 nM and with > 30-fold selectivity over other adenosine receptors.	Front Immunol, 2021, 12:687296
S0272	Derenofylline (SLV320)	Derenofylline (SLV320) is a selective and potent adenosine A1 antagonist with Ki of 1 nM. Derenofylline shows selective for adenosine A1 over A2A, A2B, and A3 receptors with Ki of 398 nM, 3981 nM, and 200 nM, respectively.
S4932	Proxyphylline	Proxyphylline (Monophylline, Spasmolysin) is a derivative of theophylline which is used as a bronchodilator and for its cardiovascular properties. It selectively antagonizes A1 adenosine receptors (Ki = 82 nM for bovine brain) versus A2 adenosine receptors (Ki = 850 µM for platelets).
E1310	DPCPX	DPCPX (PD 116948), a xanthine derivative, is a highly potent and selective adenosine A1 receptor (ADORA1) antagonist, with a Ki of 0.46 nM.	Cell Biol Toxicol, 2024, 40(1):59
E4632New	Taminadenant	Taminadenant (NIR178, PBF509) is a non-xanthine and non-furan antagonist of adenosine A2A receptor (A2AR). It can antagonize A2AR agonist-mediated cAMP accumulation and impedance responses with Kb values of 72.8 nM and 8.2 nM, respectively. It exhibits potential utility for Parkinson’s disease (PD) treatment.
S6639	BAY-545	BAY-545 is an A2B adenosine receptor antagonist with ic50 of 59 nM.
S6910	Preladenant	Preladenant (Privadenant, SCH 420814, MK-3814) is a potent, competitive and selective antagonist of the human adenosine A2A receptor with Ki of 1.1 nM.
S9608	Etrumadenant (AB928)	Etrumadenant (AB928, A2aR/A2bR antagonist-1) is a novel dual A2aR/A2bR antagonist with Kd of 1.4 nM and 2 nM for A2aR and A2bR, respectively.	Natural Product Communications, 2022, 2022;17(10)
S2945	SCH-442416	SCH-442416 is a selective antagonist of adenosine A2A receptor that binds to human and rat adenosine A2A receptors with Ki of 0.048 nM and 0.5 nM, respectively.
S5427	Alloxazine	Alloxazine (Isoalloxazine) is an A2 receptor antagonist, which is approximately 10-fold more selective for the A2B receptor than for the A2A receptor.
S3988	Theophylline-7-acetic acid	Theophylline-7-acetic acid (Acefylline, acetyloxytheophylline, Carboxymethyltheophylline), acting as an adenosine receptor antagonist, is a stimulant drug of the xanthine chemical class.
S2153	CGS 21680 HCl	CGS 21680 HCl is an adenosine A2 receptor agonist with IC50 of 22 nM, exhibits 140-fold over A1 receptor.	Clin Immunol, 2024, 266:110309 CNS Neurosci Ther, 2024, 30(5):e14726 Cell Rep Med, 2023, 4(9):101188
S1647	Adenosine	Adenosine is a nucleoside composed of a molecule of adenine attached to a ribose sugar molecule (ribofuranose) moiety via a β-N9-glycosidic bond.	Nat Commun, 2022, 13(1):5845 Cancer Res, 2022, canres.1707.2021 Immunology, 2022, 10.1111/imm.13493
S5358	Regadenoson	Regadenoson (CVT-3146, Lexiscan) is a selective A2A adenosine receptor agonist with coronary vasodilating activity.
S0498	Namodenoson (CF-102)	Namodenoson (CF-102, 2-Cl-IB-MECA) is an orally bioavailable and selective agonist of the A3 adenosine receptor (A3AR) with Ki of 0.33 nM. Namodenoson exerts an anti‑NASH effect mediated via the de‑regulation of the PI3K/NF‑κB/Wnt/β‑catenin signaling pathway.
E4032	5'-Deoxy-5'-(methylthio)adenosine	5'-Deoxy-5'-(methylthio)adenosine (Methylthioadenosine, MTA) is a naturally occurring sulfur-containing nucleoside produced by the decarboxylation of S-adenosylmethionine. This nucleoside is a potent agonist of adenosine receptors with Ki of 0.15, 1.13, 13.9, and 0.68 μM for A1, A2A, A2B, and A3, respectively.
E2985	Capadenoson	Capadenoson (BAY 68-4986) is an orally bioavailable, non-nucleoside partial adenosine A1 receptor agonist that exhibits an anti-ischemic effect.
E4450	N6-Cyclopentyladenosine	N6-Cyclopentyladenosine is an adenosine derivative and a potent adenosine receptor agonist with Ki values of 2.3 nM, 790 nM and 43 nM for human A1, A2A and A3 receptors, respectively. It acts as an anticonvulsant and might exhibit protective actions against aminophylline (AMPH)-induced seizures.
S5678	trans-Zeatin-riboside	Zeatin Riboside 是天然的细胞分裂素中最活跃和最普遍的形式，可促进细胞分裂，刺激芽增殖，抑制根形成，减缓衰老过程并激活基因表达和代谢活性。Zeatin Riboside 通过激动哺乳动物的 adenosine A2A receptor 起到免疫调节作用。
S6347	5'-N-Ethylcarboxamidoadenosine (NECA)	5'-N-Ethylcarboxamidoadenosine (NECA, 5'-(N-Ethylcarboxamido)adenosine, Adenosine-5'N-ethylcarboxamide, 5'-Ethylcarboxamidoadenosine) is a stable, nonselective adenosine receptor agonist. 5'-N-Ethylcarboxamidoadenosine acts via multiple mechanisms including: reducing diabetes-induced oxidative stress, inhibiting gene expression of IL-18, TNF-α and ICAM-1 (intercellular adhesion molecule 1 (CD54)), and blocking activation of the JNK-MAPK pathway.
E0356	MIPS521	MIPS521 is a positive allosteric modulator of the A1R that exhibits analgesic efficacy in rats in vivo.
E4632New	Taminadenant	Taminadenant (NIR178, PBF509) is a non-xanthine and non-furan antagonist of adenosine A2A receptor (A2AR). It can antagonize A2AR agonist-mediated cAMP accumulation and impedance responses with Kb values of 72.8 nM and 8.2 nM, respectively. It exhibits potential utility for Parkinson’s disease (PD) treatment.