TRP Channel

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TRP Channel製品

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• TRP Channel阻害剤 (16)
• TRP Channel活性剤(11)
• TRP Channel拮抗剤(14)
• TRP Channel作動薬(11)
• TRP Channelモジュレータ(3)
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製品コード	製品名称	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S2556	Rosiglitazone	Rosiglitazone is a potent antihyperglycemic agent and a potent thiazolidinedione insulin sensitizer with IC50 of 12, 4 and 9 nM for rat, 3T3-L1 and human adipocytes, respectively. Rosiglitazone is a pure ligand of PPAR-gamma, and has no PPAR-alpha-binding action. Rosiglitazone modulates TRP channels and induces autophagy. Rosiglitazone prevents ferroptosis.	Nat Commun, 2024, 15(1):1429 Nat Commun, 2024, 15(1):7991 Research (Wash D C), 2024, 7:0400
S8639	DPI (Diphenyleneiodonium chloride)	DPI (Diphenyleneiodonium chloride) is an inhibitor of NADPH oxidase and also a potent, irreversible, and time-, temperature-dependent iNOS/eNOS inhibitor. Diphenyleneiodonium chloride (DPI) also functions as a TRPA1 activator and selectively inhibits intracellular reactive oxygen species (ROS).	Cell Death Discov, 2024, 10(1):122 Int Immunopharmacol, 2024, 143(Pt 2):113504 J Exp Clin Cancer Res, 2023, 42(1):236
S2505	Rosiglitazone maleate	Rosiglitazone maleate, a member of the thiazolidinedione class of antihyperglycaemic agents, is a high-affinity selective agonist of the peroxisome proliferator-activated receptor-γ (PPAR-γ) with IC50 of 42 nM. Rosiglitazone maleate also modulates TRP channels and induces autophagy. Rosiglitazone prevents ferroptosis.	Stem Cell Reports, 2022, 17(11):2531-2547 Cell Death Dis, 2021, 12(11):972 Antioxidants (Basel), 2021, 10(2)155
S7999	SKF96365	SKF96365, originally identified as a blocker of receptor-mediated calcium entry, is widely used diagnostically, as a blocker of transient receptor potential canonical type (TRPC) channels.	Research Square, 2024, 10.21203/rs.3.rs-3863076/v1 J Exp Clin Cancer Res, 2023, 42(1):195 J Exp Clin Cancer Res, 2023, 42(1):195
S7115	AMG-517	AMG 517 is a potent and selective TRPV1 antagonist, and antagonizes capsaicin, proton, and heat activation of TRPV1 with IC50 of 0.76 nM, 0.62 nM and 1.3 nM， respectively.	Mucosal Immunol, 2024, S1933-0219(24)00006-0 iScience, 2023, 26(5):106749 Temperature (Austin), 2023, 10(1):136-154
S2918	HC-030031	HC-030031 (TOSLAB 829227) is a selective TRPA1 channel blocker that antagonizes AITC- and formalin-evoked calcium influx with IC50 of 6.2 μM and 5.3 μM respectively.	Lipids Health Dis, 2023, 22(1):6 Mol Pain, 2023, 19:17448069231158290 Int J Environ Res Public Health, 2022, 19(13)7985
S1990	Capsaicin(Vanilloid)	Capsaicin(Vanilloid) is an active component of chili peppers, which are plants belonging to the genus Capsicum.Capsaici is a TRPV1 agonist with an EC50 of 0.29 μM in HEK293 cells.Capsaicin is a mixture of Capsaicin and Dihydrocapsaicin.	Invest Ophthalmol Vis Sci, 2024, 65(4):30 J Tradit Complement Med, 2024, 14(2):162-172 iScience, 2023, 26(5):106749
S6657	2-APB (2-Aminoethyl Diphenylborinate)	2-APB (2-Aminoethyl Diphenylborinate) is an IP3 receptor inhibitor and regulate IP3-induced calcium release.2-APB also inhibits the SOC channel activity and activates TRP channel at higher concentrations.	iScience, 2024, 27(8):110507 Mol Med Rep, 2024, 30(6)220 PLoS Pathog, 2023, 19(3):e1011295
S8367	GSK2193874	GSK2193874 is an orally active, potent, and selective blocker of transient receptor potential vanilloid 4 (TRPV4) with IC50 values of 0.04 and 0.002 μM for hTRPV4 and rTRPV4, respectively.	Int J Oral Sci, 2024, 16(1):3 iScience, 2023, 26(5):106749 Int J Mol Sci, 2023, 24(5)4926
S8137	Capsazepine	Capsazepine acts as a competitive antagonist of capsaicin and a transient receptor potential vanilloid type 1(TRPV1) antagonist. If you want to do cell experiments, please select batch 01.	J Ethnopharmacol, 2024, 337(Pt 2):118882 Sci Adv, 2023, 9(27):eadg9593 Neuron, 2022, S0896-6273(22)00954-0
S8107	GSK1016790A	GSK1016790A (GSK101) is a novel, potent activator of TRPV4 (transient receptor potential vanilloid 4) with EC50 of 34nM in choroid plexus epithelial cells.	Am J Physiol Lung Cell Mol Physiol, 2024, 326(3):L252-L265 iScience, 2023, 26(5):106749 Int J Mol Sci, 2023, 24(5)4926
S2773	SB705498	SB705498 is a TRPV1 antagonist for hTRPV1, antagonizes capsaicin, acid, and heat activation of TRPV1 with IC50 of 3 nM, 0.1 nM and 6 nM, shows a degree of voltage dependence, exhibits >100-fold selectivity for TRPV1 over TRPM8. Phase 2.	Oxid Med Cell Longev, 2022, 2022:8096009 IUBMB Life, 2022, 10.1002/iub.2605 Biogerontology, 2016, 17(5-6):907-920
S2277	Caffeic Acid	Caffeic acid is a hydroxycinnamic acid, a naturally occurring organic compound.	Molecules, 2021, 26(5)1210 J Nutr Biochem, 2015, 26(11):1379-84 Sci Rep, 2015, 5:12580
S4022	Probenecid	Probenecid (Benemid) is a classical competitive inhibitor of organic anion transport, which is also a TRPV2 agonist and an inhibitor of TAS2R16. Probenecid is also a clinically used broad-spectrum Pannexin1 (Panx1) blocker.	Mil Med Res, 2024, 11(1):41 Front Immunol, 2022, 13:992505 Vet World, 2022, 15(2):383-389
S6637	HC-067047	HC-067047 is a selective TRPV4 channel antagonist with IC50 values of 48 nM,133 nM,and 17 nM for human, rat, and mouse TRPV4 orthologs,respectively.	Cell Physiol Biochem, 2024, 58(4):292-310 Front Pharmacol, 2023, 14:1101498 Cell Death Dis, 2020, 11(11):1009
S3763	Cinnamaldehyde	Cinnamaldehyde is a flavonoid that is naturally synthesized by the shikimate pathway. Its supplementation can improve glucose and lipid homeostasis in diabetic animals; a TRPA1 agonist.	Int J Mol Sci, 2023, 24(11)9501 Int J Mol Sci, 2023, 24(11)9501 Biosci Rep, 2021, BSR20211828
S2650	RN-1734	RN-1734 (TRPV4 Antagonist I) is a selective transient receptor potential vanilloid 4 (TRPV4) antagonist with IC50 of 2.3 μM, 5.9 μM and 3.2 μM for hTRPV4, mTRPV4 and rTRPV4, respectively. RN-1734 alleviates demyelination and inhibits glial activation and the production of tumor necrosis factor α (TNF-α) and interleukin 1β (IL-1β) without altering the number of olig2-positive cells.	Theranostics, 2022, 12(4): 1621-1638 Theranostics, 2022, 12(4):1621-1638
S3942	Cardamonin	Cardamonin (Alpinetin chalcone), isolated from the fruits of Alpinia species, is a chalconoid with anti-inflammatory and anti-tumor activity. It has been shown to be a novel antagonist of hTRPA1 cation channel with IC50 of 454 nM while does not interact with TRPV1 nor TRPV4 channel.	Cell, 2023, 186(13):2929-2949.e20 Food Funct, 2021, 12(23):11808-11818
S8691	ML204	ML204 is a novel, potent, and selective TRPC4 channel inhibitor with apparent IC50 values of about 1 μM in fluorescent intracellular Ca2+ assays and about 3 μM in whole-cell voltage clamp experiments. It exhibits some selectivity within the TRPC subfamily of channels and higher selectivity against other TRP channels and non-TRP channels.	Nature, 2019, 567(7747):262-266
S8238	SB366791	SB-366791 is a novel, potent, and selective, cinnamide TRPV1 antagonist.	Mol Pain, 2018, 14:1744806918816850
S4714	(-)-Menthol	(-)-Menthol (L-Menthol, Levomenthol, Menthomenthol, Menthacamphor) is a levo isomer of menthol and used as a cooling agent that strongly activates TRPM8.	Curr Biol, 2019, 29(11):1787-1799.e5
S6122	Cyclohexanecarboxamide	Cyclohexanecarboxamide (Ethyl menthane carboxamide, WS3, Hexahydrobenzamide) is a cooling agent and an agonist at TRPM8 receptors (EC50 = 3.7 μM).
S6638	AMG-333	AMG-333 is a potent and highly selective antagonist of TRPM8 with IC50 values of 13 nM and 30 nM for human TRPM8 and rat TRPM8.
E1890New	A-967079	A-967079 is a selective antagonist of TRPA1 receptor with IC50 values of 67 nM and 289 nM at human and rat TRPA1 receptors, respectively. A-967079 decreases the responses of wide dynamic range (WDR), and nociceptive specific (NS) neurons following noxious pinch stimulation and high-intensity mechanical stimulation in rats. It demonstrates strong penetration into the central nervous system (CNS).
S6947	MK6-83	MK6-83 is a novel Transient receptor potential melastatin member 1 (TRPML1) activator that may be used as a potential pharmacological treatment option for a specific subgroup of MLIV patients.
E4659New	Pyr3	Pyr3 is a selective and potent inhibitor of transient receptor potential canonical channel 3 (TRPC3). It inhibits TRPC3-mediated Ca2+ influx in a dose-dependent manner with the IC50 value of 0.7 μM. It holds potential for treating TRPC3-related diseases like cardiac hypertrophy.
S0825	MDR-652	MDR-652 is a potent and specific agonist of transient receptor potential vanilloid 1 (TRPV1) with Ki of 11.4 nM and 23.8 nM for hTRPV1 and rTRPV1, respectively. MDR-652 has excellent and dose-dependent analgesic activity.
S8073	Optovin	Optovin is a reversible photoactivated TRPA1 activator.
S9140	Pulegone	Pulegone, a naturally occurring organic compound, is a fragrance and flavour ingredient.
S0750	GFB-8438	GFB-8438 is a novel, potent, and subtype selective TRP channel subfamily C (TRPC) inhibitor that is equipotent against TRPC4 and TRPC5 with IC50 of 0.18 μM and 0.29 μM, and shows excellent selectivity against TRPC6, other TRP family members , NaV 1.5, as well as limited activity against the hERG channel.
S0977	AC1903	AC1903 (compound 2) is a specific and selective TRPC5 (transient receptor potential canonical channel 5) inhibitor with IC50 of 4.06 μM.	Front Med (Lausanne), 2024, 11:1381479
S6634	SAR7334	SAR7334 is a novel, highly potent and bioavailable inhibitor of TRPC6 channels.SAR7334 blocks TRPC6 currents with an IC50 of 7.9 nM in patch-clamp experiment.
S7848	QX-314 chloride	QX-314 chloride directly activates and permeates the human isoforms of TRPV1 and TRPA1 to induce inhibition of sodium channels.
E2871	Trovafloxacin Mesylate	Trovafloxacin mesylate, a broad-spectrum quinolone antibiotic, is a potent, selective and orally active pannexin 1 channel (PANX1) inhibitor with an IC50 of 4 μM for PANX1 inward current.
E2515	JT010	JT010 is a potent agonist of transient receptor potential cation channel subfamily A member 1 (TRPA1) with an EC50 of 0.65 nM.
S3756	Methyl salicylate	Methyl salicylate (Betula oil, Gaultheria oil, Methyl 2-hydroxybenzoate, Natural wintergreen oil) is an organic ester naturally produced by many species of plants, particularly wintergreens. It is an agonist for TRPA1 and TRPV1.
S6934	AMG-9810	AMG-9810 is a potent, competitive and selective vanilloid receptor 1 (TRPV1) antagonist and inhibits capsaicin activation with IC50 of 24.5 nM and 85.6 nM for human TRPV1 and rat TRPV1, repectively. AMG-9810 blocks all known modes of TRPV1 activation, including protons-, heat-, and endogenous ligands, such as anandamide, N-arachidonyl dopamine, and oleoyldopamine. AMG-9810 significantly reduces the mRNA expression of TLR2 and TLR4. AMG-9810 also promotes mouse skin tumorigenesis mediated through EGFR/Akt/mTOR signaling.
S6838	BCTC	BCTC is an orally effective and highly potent vanilloid receptor 1 (VR1/TRPV1) antagonist. BCTC inhibits capsaicin-induced and acid-induced activation of rat VR1 with IC50 of 35 nM and 6.0 nM, respectivley. BCTC exhibits anti-tumor activity.
S6409	Zucapsaicin	Zucapsaicin, the cis-isomer of capsaicin, is a topical analgesic used to treat osteoarthritis of the knee and other neuropathic pain. It is also a TRPV-1 modulator.	Arch Biochem Biophys, 2024, 754:109958
S6070	CBA (TRPM4-IN-5)	CBA (TRPM4-IN-5, Compound 5) is a highly selective blocker of the TRPM4 ion channel with an IC50 of 1.5μM.
S6410	Clemizole	Clemizole, a first-generation histamine receptor (H1) antagonist, is a potent inhibitor of behavioural and electrographic seizure activity. It has a potential therapeutic effect on hepatitis C infection and also potently inhibits TRPC5 ion channels.
S9086	Dihydrocapsaicin	Dihydrocapsaicin (6,7-Dihydrocapsaicin, 8-Methyl-N-vanillylnonanamide, CCRIS1589), found in pepper (C. annuum), is a potential nutriceutical.
S0174	TRPM8 antagonist 2	TRPM8 antagonist 2 (TRPM8 Antagonist) is a potent and selective antagonist of TRPM8 with IC50 of 0.2 nM that can be used for the pharmacological treatment of neuropathic pain syndromes.
E0028	9-Phenanthrol	9-Phenanthrol (9-Hydroxyphenanthrene, Phenanthren-9-o, 9-Phenanthrenol) is a selective TRPM4 inhibitor with an IC50 in the range of 0.02 μM, without effects on TRPM5.
E0031	RN-1747	RN-1747 is a selective TRPV4 agonist with EC50s of 0.77 μM, 4.0 μM and 4.1 μM for hTRPV4, mTRPV4 and rTRPV4, respectively. RN-1747 also antagonizes TRPM8 with IC50 of 4 μM.
E0026	ML-SI3	ML-SI3 is a potent TRPML channel inhibitor with IC50s of 4.7 µM and 1.7 µM for TRPML1 and TRPML2, respectively.	Mol Biol Cell, 2024, 35(5):ar70
S9926	ML-SA1	ML-SA1 (Mucolipin synthetic agonist 1) is an activator of TRPML channels. ML-SA1 also inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC50 values of ML-SA1 against DENV2 RNA and ZIKV RNA are 8.93 μM and 52.99 μM, respectively. ML-SA1 induces autophagy. ML-SA1 can be used for the research of broad-spectrum antiviral.
S5419	1,4-Cineole	1,4-Cineole (Isocineole) is a widely distributed, natural, oxygenated monoterpene. 1,4-Cineole, present in eucalyptus oil, activates both human TRPM8 and human TRPA1.
E2684	Icilin	Icilin is an agonist of the transient receptor potential M8 (TRPM8) ion channel with an EC50 of 1.4 μM.
E4648New	Pico145	Pico145(HC-608) is a selective inhibitor of TRPC1/4/5 channels. It inhibits (−)-englerin A-activated TRPC4/TRPC5 channels, with IC50 values of 0.349 and 1.3 nM, respectively. It exhibits no effect on TRPC3, TRPC6, TRPV1, TRPV4, TRPA1, TRPM2, TRPM8.
S4787	Methyl syringate	Methyl syringate (Syringic Acid Methyl Ester), a plant phenolic compound, is a specific and selective TRPA1 agonist.
S3851	Camphor	Camphor (2-Bornanone, Bornan-2-one, 2-Camphanone, Formosa) is a bicyclic monoterpene ketone found widely in plants, especially cinnamomum camphora and used topically as a skin antipruritic and as an anti-infective agent.	iScience, 2023, 26(5):106749
S4516	(+)-Camphor	Camphor is a waxy, flammable, white or transparent solid with a strong aroma, often used to relieve pain, reduce itching and treat fungal infections. It can activate TRPV1 and TRPV3.
S3867	(E)-Cardamonin	(E)-Cardamonin (Alpinetin chalcone, cardamomin) is a naturally occurring chalcone with strong anti-inflammatory activity. It is a novel TRPA1 antagonist with IC50 of 454 nM and also a NF-κB inhibitor.
S2963	WS-12	WS-12 is a potent TRPM8 agonist with an EC50 of 39 nM.
E4673New	AMTB hydrochloride	AMTB hydrochloride is a blocker of the transient receptor potential melastatin 8 (TRPM8) ion channel. It reduces the activation of TRPM8 channels induced by icilin, as assessed through a Ca2+ influx assay, with a pIC50 of 6.23. It is used as a tool to evaluate the role of this channel in bladder rhythmic contraction.
S1990	Capsaicin(Vanilloid)	Capsaicin(Vanilloid) is an active component of chili peppers, which are plants belonging to the genus Capsicum.Capsaici is a TRPV1 agonist with an EC50 of 0.29 μM in HEK293 cells.Capsaicin is a mixture of Capsaicin and Dihydrocapsaicin.	Invest Ophthalmol Vis Sci, 2024, 65(4):30 J Tradit Complement Med, 2024, 14(2):162-172 iScience, 2023, 26(5):106749
S4022	Probenecid	Probenecid (Benemid) is a classical competitive inhibitor of organic anion transport, which is also a TRPV2 agonist and an inhibitor of TAS2R16. Probenecid is also a clinically used broad-spectrum Pannexin1 (Panx1) blocker.	Mil Med Res, 2024, 11(1):41 Front Immunol, 2022, 13:992505 Vet World, 2022, 15(2):383-389
S3763	Cinnamaldehyde	Cinnamaldehyde is a flavonoid that is naturally synthesized by the shikimate pathway. Its supplementation can improve glucose and lipid homeostasis in diabetic animals; a TRPA1 agonist.	Int J Mol Sci, 2023, 24(11)9501 Int J Mol Sci, 2023, 24(11)9501 Biosci Rep, 2021, BSR20211828
S6122	Cyclohexanecarboxamide	Cyclohexanecarboxamide (Ethyl menthane carboxamide, WS3, Hexahydrobenzamide) is a cooling agent and an agonist at TRPM8 receptors (EC50 = 3.7 μM).
S0825	MDR-652	MDR-652 is a potent and specific agonist of transient receptor potential vanilloid 1 (TRPV1) with Ki of 11.4 nM and 23.8 nM for hTRPV1 and rTRPV1, respectively. MDR-652 has excellent and dose-dependent analgesic activity.
E2515	JT010	JT010 is a potent agonist of transient receptor potential cation channel subfamily A member 1 (TRPA1) with an EC50 of 0.65 nM.
S9086	Dihydrocapsaicin	Dihydrocapsaicin (6,7-Dihydrocapsaicin, 8-Methyl-N-vanillylnonanamide, CCRIS1589), found in pepper (C. annuum), is a potential nutriceutical.
E0031	RN-1747	RN-1747 is a selective TRPV4 agonist with EC50s of 0.77 μM, 4.0 μM and 4.1 μM for hTRPV4, mTRPV4 and rTRPV4, respectively. RN-1747 also antagonizes TRPM8 with IC50 of 4 μM.
E2684	Icilin	Icilin is an agonist of the transient receptor potential M8 (TRPM8) ion channel with an EC50 of 1.4 μM.
S4787	Methyl syringate	Methyl syringate (Syringic Acid Methyl Ester), a plant phenolic compound, is a specific and selective TRPA1 agonist.
S2963	WS-12	WS-12 is a potent TRPM8 agonist with an EC50 of 39 nM.
S7999	SKF96365	SKF96365, originally identified as a blocker of receptor-mediated calcium entry, is widely used diagnostically, as a blocker of transient receptor potential canonical type (TRPC) channels.	Research Square, 2024, 10.21203/rs.3.rs-3863076/v1 J Exp Clin Cancer Res, 2023, 42(1):195 J Exp Clin Cancer Res, 2023, 42(1):195
S2918	HC-030031	HC-030031 (TOSLAB 829227) is a selective TRPA1 channel blocker that antagonizes AITC- and formalin-evoked calcium influx with IC50 of 6.2 μM and 5.3 μM respectively.	Lipids Health Dis, 2023, 22(1):6 Mol Pain, 2023, 19:17448069231158290 Int J Environ Res Public Health, 2022, 19(13)7985
S8367	GSK2193874	GSK2193874 is an orally active, potent, and selective blocker of transient receptor potential vanilloid 4 (TRPV4) with IC50 values of 0.04 and 0.002 μM for hTRPV4 and rTRPV4, respectively.	Int J Oral Sci, 2024, 16(1):3 iScience, 2023, 26(5):106749 Int J Mol Sci, 2023, 24(5)4926
S2277	Caffeic Acid	Caffeic acid is a hydroxycinnamic acid, a naturally occurring organic compound.	Molecules, 2021, 26(5)1210 J Nutr Biochem, 2015, 26(11):1379-84 Sci Rep, 2015, 5:12580
S8691	ML204	ML204 is a novel, potent, and selective TRPC4 channel inhibitor with apparent IC50 values of about 1 μM in fluorescent intracellular Ca2+ assays and about 3 μM in whole-cell voltage clamp experiments. It exhibits some selectivity within the TRPC subfamily of channels and higher selectivity against other TRP channels and non-TRP channels.	Nature, 2019, 567(7747):262-266
E4659New	Pyr3	Pyr3 is a selective and potent inhibitor of transient receptor potential canonical channel 3 (TRPC3). It inhibits TRPC3-mediated Ca2+ influx in a dose-dependent manner with the IC50 value of 0.7 μM. It holds potential for treating TRPC3-related diseases like cardiac hypertrophy.
S9140	Pulegone	Pulegone, a naturally occurring organic compound, is a fragrance and flavour ingredient.
S0750	GFB-8438	GFB-8438 is a novel, potent, and subtype selective TRP channel subfamily C (TRPC) inhibitor that is equipotent against TRPC4 and TRPC5 with IC50 of 0.18 μM and 0.29 μM, and shows excellent selectivity against TRPC6, other TRP family members , NaV 1.5, as well as limited activity against the hERG channel.
S0977	AC1903	AC1903 (compound 2) is a specific and selective TRPC5 (transient receptor potential canonical channel 5) inhibitor with IC50 of 4.06 μM.	Front Med (Lausanne), 2024, 11:1381479
S6634	SAR7334	SAR7334 is a novel, highly potent and bioavailable inhibitor of TRPC6 channels.SAR7334 blocks TRPC6 currents with an IC50 of 7.9 nM in patch-clamp experiment.
E2871	Trovafloxacin Mesylate	Trovafloxacin mesylate, a broad-spectrum quinolone antibiotic, is a potent, selective and orally active pannexin 1 channel (PANX1) inhibitor with an IC50 of 4 μM for PANX1 inward current.
S6070	CBA (TRPM4-IN-5)	CBA (TRPM4-IN-5, Compound 5) is a highly selective blocker of the TRPM4 ion channel with an IC50 of 1.5μM.
S6410	Clemizole	Clemizole, a first-generation histamine receptor (H1) antagonist, is a potent inhibitor of behavioural and electrographic seizure activity. It has a potential therapeutic effect on hepatitis C infection and also potently inhibits TRPC5 ion channels.
E0028	9-Phenanthrol	9-Phenanthrol (9-Hydroxyphenanthrene, Phenanthren-9-o, 9-Phenanthrenol) is a selective TRPM4 inhibitor with an IC50 in the range of 0.02 μM, without effects on TRPM5.
E0026	ML-SI3	ML-SI3 is a potent TRPML channel inhibitor with IC50s of 4.7 µM and 1.7 µM for TRPML1 and TRPML2, respectively.	Mol Biol Cell, 2024, 35(5):ar70
E4648New	Pico145	Pico145(HC-608) is a selective inhibitor of TRPC1/4/5 channels. It inhibits (−)-englerin A-activated TRPC4/TRPC5 channels, with IC50 values of 0.349 and 1.3 nM, respectively. It exhibits no effect on TRPC3, TRPC6, TRPV1, TRPV4, TRPA1, TRPM2, TRPM8.
S8639	DPI (Diphenyleneiodonium chloride)	DPI (Diphenyleneiodonium chloride) is an inhibitor of NADPH oxidase and also a potent, irreversible, and time-, temperature-dependent iNOS/eNOS inhibitor. Diphenyleneiodonium chloride (DPI) also functions as a TRPA1 activator and selectively inhibits intracellular reactive oxygen species (ROS).	Cell Death Discov, 2024, 10(1):122 Int Immunopharmacol, 2024, 143(Pt 2):113504 J Exp Clin Cancer Res, 2023, 42(1):236
S6657	2-APB (2-Aminoethyl Diphenylborinate)	2-APB (2-Aminoethyl Diphenylborinate) is an IP3 receptor inhibitor and regulate IP3-induced calcium release.2-APB also inhibits the SOC channel activity and activates TRP channel at higher concentrations.	iScience, 2024, 27(8):110507 Mol Med Rep, 2024, 30(6)220 PLoS Pathog, 2023, 19(3):e1011295
S8107	GSK1016790A	GSK1016790A (GSK101) is a novel, potent activator of TRPV4 (transient receptor potential vanilloid 4) with EC50 of 34nM in choroid plexus epithelial cells.	Am J Physiol Lung Cell Mol Physiol, 2024, 326(3):L252-L265 iScience, 2023, 26(5):106749 Int J Mol Sci, 2023, 24(5)4926
S4714	(-)-Menthol	(-)-Menthol (L-Menthol, Levomenthol, Menthomenthol, Menthacamphor) is a levo isomer of menthol and used as a cooling agent that strongly activates TRPM8.	Curr Biol, 2019, 29(11):1787-1799.e5
S6947	MK6-83	MK6-83 is a novel Transient receptor potential melastatin member 1 (TRPML1) activator that may be used as a potential pharmacological treatment option for a specific subgroup of MLIV patients.
S8073	Optovin	Optovin is a reversible photoactivated TRPA1 activator.
S7848	QX-314 chloride	QX-314 chloride directly activates and permeates the human isoforms of TRPV1 and TRPA1 to induce inhibition of sodium channels.
S9926	ML-SA1	ML-SA1 (Mucolipin synthetic agonist 1) is an activator of TRPML channels. ML-SA1 also inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC50 values of ML-SA1 against DENV2 RNA and ZIKV RNA are 8.93 μM and 52.99 μM, respectively. ML-SA1 induces autophagy. ML-SA1 can be used for the research of broad-spectrum antiviral.
S5419	1,4-Cineole	1,4-Cineole (Isocineole) is a widely distributed, natural, oxygenated monoterpene. 1,4-Cineole, present in eucalyptus oil, activates both human TRPM8 and human TRPA1.
S3851	Camphor	Camphor (2-Bornanone, Bornan-2-one, 2-Camphanone, Formosa) is a bicyclic monoterpene ketone found widely in plants, especially cinnamomum camphora and used topically as a skin antipruritic and as an anti-infective agent.	iScience, 2023, 26(5):106749
S4516	(+)-Camphor	Camphor is a waxy, flammable, white or transparent solid with a strong aroma, often used to relieve pain, reduce itching and treat fungal infections. It can activate TRPV1 and TRPV3.
S7115	AMG-517	AMG 517 is a potent and selective TRPV1 antagonist, and antagonizes capsaicin, proton, and heat activation of TRPV1 with IC50 of 0.76 nM, 0.62 nM and 1.3 nM， respectively.	Mucosal Immunol, 2024, S1933-0219(24)00006-0 iScience, 2023, 26(5):106749 Temperature (Austin), 2023, 10(1):136-154
S8137	Capsazepine	Capsazepine acts as a competitive antagonist of capsaicin and a transient receptor potential vanilloid type 1(TRPV1) antagonist. If you want to do cell experiments, please select batch 01.	J Ethnopharmacol, 2024, 337(Pt 2):118882 Sci Adv, 2023, 9(27):eadg9593 Neuron, 2022, S0896-6273(22)00954-0
S2773	SB705498	SB705498 is a TRPV1 antagonist for hTRPV1, antagonizes capsaicin, acid, and heat activation of TRPV1 with IC50 of 3 nM, 0.1 nM and 6 nM, shows a degree of voltage dependence, exhibits >100-fold selectivity for TRPV1 over TRPM8. Phase 2.	Oxid Med Cell Longev, 2022, 2022:8096009 IUBMB Life, 2022, 10.1002/iub.2605 Biogerontology, 2016, 17(5-6):907-920
S6637	HC-067047	HC-067047 is a selective TRPV4 channel antagonist with IC50 values of 48 nM,133 nM,and 17 nM for human, rat, and mouse TRPV4 orthologs,respectively.	Cell Physiol Biochem, 2024, 58(4):292-310 Front Pharmacol, 2023, 14:1101498 Cell Death Dis, 2020, 11(11):1009
S2650	RN-1734	RN-1734 (TRPV4 Antagonist I) is a selective transient receptor potential vanilloid 4 (TRPV4) antagonist with IC50 of 2.3 μM, 5.9 μM and 3.2 μM for hTRPV4, mTRPV4 and rTRPV4, respectively. RN-1734 alleviates demyelination and inhibits glial activation and the production of tumor necrosis factor α (TNF-α) and interleukin 1β (IL-1β) without altering the number of olig2-positive cells.	Theranostics, 2022, 12(4): 1621-1638 Theranostics, 2022, 12(4):1621-1638
S3942	Cardamonin	Cardamonin (Alpinetin chalcone), isolated from the fruits of Alpinia species, is a chalconoid with anti-inflammatory and anti-tumor activity. It has been shown to be a novel antagonist of hTRPA1 cation channel with IC50 of 454 nM while does not interact with TRPV1 nor TRPV4 channel.	Cell, 2023, 186(13):2929-2949.e20 Food Funct, 2021, 12(23):11808-11818
S8238	SB366791	SB-366791 is a novel, potent, and selective, cinnamide TRPV1 antagonist.	Mol Pain, 2018, 14:1744806918816850
S6638	AMG-333	AMG-333 is a potent and highly selective antagonist of TRPM8 with IC50 values of 13 nM and 30 nM for human TRPM8 and rat TRPM8.
E1890New	A-967079	A-967079 is a selective antagonist of TRPA1 receptor with IC50 values of 67 nM and 289 nM at human and rat TRPA1 receptors, respectively. A-967079 decreases the responses of wide dynamic range (WDR), and nociceptive specific (NS) neurons following noxious pinch stimulation and high-intensity mechanical stimulation in rats. It demonstrates strong penetration into the central nervous system (CNS).
S3756	Methyl salicylate	Methyl salicylate (Betula oil, Gaultheria oil, Methyl 2-hydroxybenzoate, Natural wintergreen oil) is an organic ester naturally produced by many species of plants, particularly wintergreens. It is an agonist for TRPA1 and TRPV1.
S6934	AMG-9810	AMG-9810 is a potent, competitive and selective vanilloid receptor 1 (TRPV1) antagonist and inhibits capsaicin activation with IC50 of 24.5 nM and 85.6 nM for human TRPV1 and rat TRPV1, repectively. AMG-9810 blocks all known modes of TRPV1 activation, including protons-, heat-, and endogenous ligands, such as anandamide, N-arachidonyl dopamine, and oleoyldopamine. AMG-9810 significantly reduces the mRNA expression of TLR2 and TLR4. AMG-9810 also promotes mouse skin tumorigenesis mediated through EGFR/Akt/mTOR signaling.
S6838	BCTC	BCTC is an orally effective and highly potent vanilloid receptor 1 (VR1/TRPV1) antagonist. BCTC inhibits capsaicin-induced and acid-induced activation of rat VR1 with IC50 of 35 nM and 6.0 nM, respectivley. BCTC exhibits anti-tumor activity.
S0174	TRPM8 antagonist 2	TRPM8 antagonist 2 (TRPM8 Antagonist) is a potent and selective antagonist of TRPM8 with IC50 of 0.2 nM that can be used for the pharmacological treatment of neuropathic pain syndromes.
S3867	(E)-Cardamonin	(E)-Cardamonin (Alpinetin chalcone, cardamomin) is a naturally occurring chalcone with strong anti-inflammatory activity. It is a novel TRPA1 antagonist with IC50 of 454 nM and also a NF-κB inhibitor.
S1990	Capsaicin(Vanilloid)	Capsaicin(Vanilloid) is an active component of chili peppers, which are plants belonging to the genus Capsicum.Capsaici is a TRPV1 agonist with an EC50 of 0.29 μM in HEK293 cells.Capsaicin is a mixture of Capsaicin and Dihydrocapsaicin.	Invest Ophthalmol Vis Sci, 2024, 65(4):30 J Tradit Complement Med, 2024, 14(2):162-172 iScience, 2023, 26(5):106749
S4022	Probenecid	Probenecid (Benemid) is a classical competitive inhibitor of organic anion transport, which is also a TRPV2 agonist and an inhibitor of TAS2R16. Probenecid is also a clinically used broad-spectrum Pannexin1 (Panx1) blocker.	Mil Med Res, 2024, 11(1):41 Front Immunol, 2022, 13:992505 Vet World, 2022, 15(2):383-389
S3763	Cinnamaldehyde	Cinnamaldehyde is a flavonoid that is naturally synthesized by the shikimate pathway. Its supplementation can improve glucose and lipid homeostasis in diabetic animals; a TRPA1 agonist.	Int J Mol Sci, 2023, 24(11)9501 Int J Mol Sci, 2023, 24(11)9501 Biosci Rep, 2021, BSR20211828
S6122	Cyclohexanecarboxamide	Cyclohexanecarboxamide (Ethyl menthane carboxamide, WS3, Hexahydrobenzamide) is a cooling agent and an agonist at TRPM8 receptors (EC50 = 3.7 μM).
S0825	MDR-652	MDR-652 is a potent and specific agonist of transient receptor potential vanilloid 1 (TRPV1) with Ki of 11.4 nM and 23.8 nM for hTRPV1 and rTRPV1, respectively. MDR-652 has excellent and dose-dependent analgesic activity.
E2515	JT010	JT010 is a potent agonist of transient receptor potential cation channel subfamily A member 1 (TRPA1) with an EC50 of 0.65 nM.
S9086	Dihydrocapsaicin	Dihydrocapsaicin (6,7-Dihydrocapsaicin, 8-Methyl-N-vanillylnonanamide, CCRIS1589), found in pepper (C. annuum), is a potential nutriceutical.
E0031	RN-1747	RN-1747 is a selective TRPV4 agonist with EC50s of 0.77 μM, 4.0 μM and 4.1 μM for hTRPV4, mTRPV4 and rTRPV4, respectively. RN-1747 also antagonizes TRPM8 with IC50 of 4 μM.
E2684	Icilin	Icilin is an agonist of the transient receptor potential M8 (TRPM8) ion channel with an EC50 of 1.4 μM.
S4787	Methyl syringate	Methyl syringate (Syringic Acid Methyl Ester), a plant phenolic compound, is a specific and selective TRPA1 agonist.
S2963	WS-12	WS-12 is a potent TRPM8 agonist with an EC50 of 39 nM.
S2556	Rosiglitazone	Rosiglitazone is a potent antihyperglycemic agent and a potent thiazolidinedione insulin sensitizer with IC50 of 12, 4 and 9 nM for rat, 3T3-L1 and human adipocytes, respectively. Rosiglitazone is a pure ligand of PPAR-gamma, and has no PPAR-alpha-binding action. Rosiglitazone modulates TRP channels and induces autophagy. Rosiglitazone prevents ferroptosis.	Nat Commun, 2024, 15(1):1429 Nat Commun, 2024, 15(1):7991 Research (Wash D C), 2024, 7:0400
S2505	Rosiglitazone maleate	Rosiglitazone maleate, a member of the thiazolidinedione class of antihyperglycaemic agents, is a high-affinity selective agonist of the peroxisome proliferator-activated receptor-γ (PPAR-γ) with IC50 of 42 nM. Rosiglitazone maleate also modulates TRP channels and induces autophagy. Rosiglitazone prevents ferroptosis.	Stem Cell Reports, 2022, 17(11):2531-2547 Cell Death Dis, 2021, 12(11):972 Antioxidants (Basel), 2021, 10(2)155
S6409	Zucapsaicin	Zucapsaicin, the cis-isomer of capsaicin, is a topical analgesic used to treat osteoarthritis of the knee and other neuropathic pain. It is also a TRPV-1 modulator.	Arch Biochem Biophys, 2024, 754:109958
E1890New	A-967079	A-967079 is a selective antagonist of TRPA1 receptor with IC50 values of 67 nM and 289 nM at human and rat TRPA1 receptors, respectively. A-967079 decreases the responses of wide dynamic range (WDR), and nociceptive specific (NS) neurons following noxious pinch stimulation and high-intensity mechanical stimulation in rats. It demonstrates strong penetration into the central nervous system (CNS).
E4659New	Pyr3	Pyr3 is a selective and potent inhibitor of transient receptor potential canonical channel 3 (TRPC3). It inhibits TRPC3-mediated Ca2+ influx in a dose-dependent manner with the IC50 value of 0.7 μM. It holds potential for treating TRPC3-related diseases like cardiac hypertrophy.
E4648New	Pico145	Pico145(HC-608) is a selective inhibitor of TRPC1/4/5 channels. It inhibits (−)-englerin A-activated TRPC4/TRPC5 channels, with IC50 values of 0.349 and 1.3 nM, respectively. It exhibits no effect on TRPC3, TRPC6, TRPV1, TRPV4, TRPA1, TRPM2, TRPM8.
E4673New	AMTB hydrochloride	AMTB hydrochloride is a blocker of the transient receptor potential melastatin 8 (TRPM8) ion channel. It reduces the activation of TRPM8 channels induced by icilin, as assessed through a Ca2+ influx assay, with a pIC50 of 6.23. It is used as a tool to evaluate the role of this channel in bladder rhythmic contraction.