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Hydroxylase
Hydroxylase製品
- All (15)
- Hydroxylase阻害剤 (13)
- Hydroxylase活性剤(2)
- 新製品
| 製品コード | 製品名称 | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
|---|---|---|---|---|
| S7483 | DMOG | DMOG (Dimethyloxalylglycine) is an antagonist of α-ketoglutarate cofactor and inhibitor for HIF prolylhydroxylase, leading to stabilisation and accumulation of HIF-1α protein in the nucleus. DMOG enhances autophagy.Solutions are unstable and should be fresh-prepared. |
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| S1379 | Isotretinoin (13-cis retinoic acid) | Isotretinoin (13-cis retinoic acid) was developed to be used as a chemotherapy medication for the treatment of brain cancer, pancreatic cancer and more. | ||
| S7456 | Osilodrostat (LCI699) | LCI699 (Osilodrostat) is a potent inhibitor of 11β-hydroxylase (CYP11B), an enzyme catalyzing the final step of cortisol synthesis. | ||
| S8172 | Ro 61-8048 | Ro 61-8048 is a high-affinity kynurenine 3-hydroxylase (KMO) inhibitor with IC50 and Ki of 37 nM and 4.8 nM, respectively. | ||
| S4130 | Meldonium | Meldonium (MET-88, Quaterin) is an inhibitor of biosynthesis of L-carnitine by gamma-butyrobetaine (GBB) hydroxylase and as a competitive inhibitor of renal carnitine reabsorption. | ||
| S4586 | 4-Chloro-DL-phenylalanine | 4-Chloro-DL-phenylalanine (Fenclonine, PCPA, CP-10188) is a selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). 4-Chloro-DL-phenylalanine acts pharmacologically to deplete endogenous levels of serotonin. | ||
| S2173 | Telotristat Etiprate (LX 1606 Hippurate) | Telotristat Etiprate (LX 1606 Hippurate) is an orally bioavailable, tryptophan hydroxylase (TPH) inhibitor with potential antiserotonergic activity. Phase 3. | ||
| S2695 | Nepicastat (SYN-117) HCl | Nepicastat (SYN-117) HCl is a potent and selective inhibitor of both bovine and human dopamine-β-hydroxylase with IC50 of 8.5 nM and 9 nM, with negligible affinity for twelve other enzymes and thirteen neurotransmitter receptors. Phase 2. | ||
| S3273 | Hypericin | Hypericin (Hyp, HY) is a naturally occurring substance found in the common St. John's Wort (Hypericum species) with antidepressive, antineoplastic and antiviral (human immunodeficiency and hepatitis C virus) activities. Hypericin has inhibitory effects on MAO (monoaminoxidase), PKC (protein kinase C), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450). | ||
| S4926 | (R)-Nepicastat HCl | (R)-Nepicastat HCl (RS-25560-198), the R-enantiomer of Nepicastat HCl, is a potent and selective inhibitor with IC50 of 25.1 nM and 18.3 nM for bovine and human dopamine-β-hydroxylase, with negligible affinity for twelve other enzymes and thirteen neurotransmitter receptors. | ||
| S5797 | Metyrosine | Metyrosine (α-Methyltyrosine), an antihypertensive drug, is a tyrosine hydroxylase inhibitor. | ||
| S6044 | H-Tyr(3-I)-OH | H-Tyr(3-I)-OH (3-Iodo-L-tyrosine) is responsible for catalyzing the first step of the noradrenergic biosynthesis pathway. H-Tyr(3-I)-OH is an effective tyrosine hydroxylase inhibitor. | ||
| S9568 | Sapropterin (Tetrahydrobiopterin) Dihydrochloride | Sapropterin (Tetrahydrobiopterin) Dihydrochloride, a synthetic preparation of the dihydrochloride salt of naturally occurring tetrahydrobiopterin (BH4), is a phenylalanine hydroxylase activator. | ||
| S3100 | 2-Thiouracil | 2-Thiouracil(Deracil,Thiouracil) is a thiolated uracil derivative that is a known antihyperthyroid agent. | ||
| E2231 | Xanthoangelol | Xanthoangelol, a chalcone found in the roots of Angelica keiskei, is a nonselective monoamine oxidase (MAO) inhibitor and a potent dopamine β-hydroxylase (DBH) inhibitor. It has anti-inflammatory, antibiotic and pro-apoptotic activities. | ||
| S7483 | DMOG | DMOG (Dimethyloxalylglycine) is an antagonist of α-ketoglutarate cofactor and inhibitor for HIF prolylhydroxylase, leading to stabilisation and accumulation of HIF-1α protein in the nucleus. DMOG enhances autophagy.Solutions are unstable and should be fresh-prepared. |
|
|
| S7456 | Osilodrostat (LCI699) | LCI699 (Osilodrostat) is a potent inhibitor of 11β-hydroxylase (CYP11B), an enzyme catalyzing the final step of cortisol synthesis. | ||
| S8172 | Ro 61-8048 | Ro 61-8048 is a high-affinity kynurenine 3-hydroxylase (KMO) inhibitor with IC50 and Ki of 37 nM and 4.8 nM, respectively. | ||
| S4130 | Meldonium | Meldonium (MET-88, Quaterin) is an inhibitor of biosynthesis of L-carnitine by gamma-butyrobetaine (GBB) hydroxylase and as a competitive inhibitor of renal carnitine reabsorption. | ||
| S4586 | 4-Chloro-DL-phenylalanine | 4-Chloro-DL-phenylalanine (Fenclonine, PCPA, CP-10188) is a selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). 4-Chloro-DL-phenylalanine acts pharmacologically to deplete endogenous levels of serotonin. | ||
| S2173 | Telotristat Etiprate (LX 1606 Hippurate) | Telotristat Etiprate (LX 1606 Hippurate) is an orally bioavailable, tryptophan hydroxylase (TPH) inhibitor with potential antiserotonergic activity. Phase 3. | ||
| S2695 | Nepicastat (SYN-117) HCl | Nepicastat (SYN-117) HCl is a potent and selective inhibitor of both bovine and human dopamine-β-hydroxylase with IC50 of 8.5 nM and 9 nM, with negligible affinity for twelve other enzymes and thirteen neurotransmitter receptors. Phase 2. | ||
| S3273 | Hypericin | Hypericin (Hyp, HY) is a naturally occurring substance found in the common St. John's Wort (Hypericum species) with antidepressive, antineoplastic and antiviral (human immunodeficiency and hepatitis C virus) activities. Hypericin has inhibitory effects on MAO (monoaminoxidase), PKC (protein kinase C), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450). | ||
| S4926 | (R)-Nepicastat HCl | (R)-Nepicastat HCl (RS-25560-198), the R-enantiomer of Nepicastat HCl, is a potent and selective inhibitor with IC50 of 25.1 nM and 18.3 nM for bovine and human dopamine-β-hydroxylase, with negligible affinity for twelve other enzymes and thirteen neurotransmitter receptors. | ||
| S5797 | Metyrosine | Metyrosine (α-Methyltyrosine), an antihypertensive drug, is a tyrosine hydroxylase inhibitor. | ||
| S6044 | H-Tyr(3-I)-OH | H-Tyr(3-I)-OH (3-Iodo-L-tyrosine) is responsible for catalyzing the first step of the noradrenergic biosynthesis pathway. H-Tyr(3-I)-OH is an effective tyrosine hydroxylase inhibitor. | ||
| S3100 | 2-Thiouracil | 2-Thiouracil(Deracil,Thiouracil) is a thiolated uracil derivative that is a known antihyperthyroid agent. | ||
| E2231 | Xanthoangelol | Xanthoangelol, a chalcone found in the roots of Angelica keiskei, is a nonselective monoamine oxidase (MAO) inhibitor and a potent dopamine β-hydroxylase (DBH) inhibitor. It has anti-inflammatory, antibiotic and pro-apoptotic activities. | ||
| S1379 | Isotretinoin (13-cis retinoic acid) | Isotretinoin (13-cis retinoic acid) was developed to be used as a chemotherapy medication for the treatment of brain cancer, pancreatic cancer and more. | ||
| S9568 | Sapropterin (Tetrahydrobiopterin) Dihydrochloride | Sapropterin (Tetrahydrobiopterin) Dihydrochloride, a synthetic preparation of the dihydrochloride salt of naturally occurring tetrahydrobiopterin (BH4), is a phenylalanine hydroxylase activator. |
Hydroxylase阻害剤の選択性比較
Tags: Hydroxylase activity | Dopamine-β-Hydroxylase activity | Hydroxylase inhibitor review
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