ホームページ Metabolism Hydroxylase DBH 選択性 阻害剤
  • DBH
  • KMO
  • TPH

DBH 選択性 阻害剤

製品コード 製品名 製品説明 Selective / Pan IC50 / Ki
S2695 Nepicastat (SYN-117) HCl Nepicastat (SYN-117) HCl is a potent and selective inhibitor of both bovine and human dopamine-β-hydroxylase with IC50 of 8.5 nM and 9 nM, with negligible affinity for twelve other enzymes and thirteen neurotransmitter receptors. Phase 2. Selective Bovine dopamine-beta-hydroxylase, IC50: 8.5 nM; Human dopamine-beta-hydroxylase, IC50: 9 nM
S4926 (R)-Nepicastat HCl (R)-Nepicastat HCl (RS-25560-198), the R-enantiomer of Nepicastat HCl, is a potent and selective inhibitor with IC50 of 25.1 nM and 18.3 nM for bovine and human dopamine-β-hydroxylase, with negligible affinity for twelve other enzymes and thirteen neurotransmitter receptors. Selective Bovine dopamine-beta-hydroxylase, IC50: 25.1 nM; Human dopamine-beta-hydroxylase, IC50: 18.3 nM
S3273 Hypericin Hypericin (Hyp, HY) is a naturally occurring substance found in the common St. John's Wort (Hypericum species) with antidepressive, antineoplastic and antiviral (human immunodeficiency and hepatitis C virus) activities. Hypericin has inhibitory effects on MAO (monoaminoxidase), PKC (protein kinase C), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450). Selective