ホームページ DNA Damage/DNA Repair Antineoplastic and Immunosuppressive Antibiotics inhibitor - DNA/RNA Synthesis inhibitor - Selection Antibiotics for Transfected Cell chemical - Apoptosis related activator - ADC Cytotoxin chemical Mitomycin C For research use only.

Mitomycin C

別名：Ametycine

Mitomycin C (Ametycine) is an antineoplastic antibiotic by inhibiting DNA synthesis, used to treat different cancers. Mitomycin C induces apoptosis in a caspases-dependent and Fas/CD95-independent manner.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing.

Mitomycin C化学構造

CAS No. 50-07-7

サイズ 価格(税別) 在庫状況
10mM (1mL in DMSO) JPY 41500 国内在庫あり
JPY 29500 国内在庫あり
JPY 71500 国内在庫あり
JPY 145500 国内在庫あり
JPY 445500 国内在庫なし(納期7~10日)

代表番号: 045-509-1970|電子メール：[email protected]
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文献中Selleckの製品使用例（122）

製品安全説明書

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Mitomycin C関連製品

Antineoplastic and Immunosuppressive Antibiotics阻害剤の選択性比較

Cell Data

Cell Lines Assay Type Concentration Incubation Time 活性情報 PMID
IE Antiproliferative assay 72 hrs Antiproliferative activity against human IE cells after 72 hrs by trypan blue exclusion assay, EC50 = 1.46 μM. 19674905
SVCT-M12 Antiproliferative assay 72 hrs Antiproliferative activity against human SVCT-M12 cells after 72 hrs by trypan blue exclusion assay, EC50 = 0.96 μM. 19674905
MCF7 Antiproliferative assay 72 hrs Antiproliferative activity against human MCF7 cells after 72 hrs by trypan blue exclusion assay, EC50 = 0.96 μM. 19674905
Hs888Lu Antiproliferative assay 72 hrs Antiproliferative activity against human Hs888Lu cells after 72 hrs by trypan blue exclusion assay, EC50 = 0.56 μM. 19674905
A549 Antiproliferative assay 72 hrs Antiproliferative activity against human A549 cells after 72 hrs by trypan blue exclusion assay, EC50 = 0.43 μM. 19674905
PC3 Antiproliferative assay 72 hrs Antiproliferative activity against human PC3 cells after 72 hrs by trypan blue exclusion assay, EC50 = 0.14 μM. 19674905
SMMC7721 Cytotoxicity assay 48 hrs Cytotoxicity against human SMMC7721 cells after 48 hrs by SRB assay, IC50 = 5.4 μM. 19432411
HeLa Cytotoxicity assay 48 hrs Cytotoxicity against human HeLa cells after 48 hrs by SRB assay, IC50 = 3.3 μM. 19432411
HL60 Cytotoxicity assay 48 hrs Cytotoxicity against human HL60 cells after 48 hrs by SRB assay, IC50 = 1.5 μM. 19432411
HCT8 Cytotoxicity assay 72 hrs Cytotoxicity against human HCT8 cells after 72 hrs by SRB assay, IC90 = 5.7 μM. 18845441
HCT8 Cytotoxicity assay 72 hrs Cytotoxicity against human HCT8 cells after 72 hrs by SRB assay, IC50 = 0.083 μM. 18845441
A549 Cytotoxicity assay 72 hrs Cytotoxicity against human A549 cells after 72 hrs by Alamar Blue assay, IC50 = 0.4 μM. 18752870
MCF7 Cytotoxicity assay 72 hrs Cytotoxicity against human MCF7 cells after 72 hrs by Alamar Blue assay, IC50 = 0.2 μM. 18752870
BAC29 Cytotoxicity assay 3 days Cytotoxicity against BRCA2-proficient Chinese hamster BAC29 mutant cells after 3 days by WST1 cell viability assay, IC50 = 0.4 μM. 18505284
V-C8 Cytotoxicity assay 3 days Cytotoxicity against BRCA2-deficient Chinese hamster V-C8 mutant cells after 3 days by WST1 cell viability assay, IC50 = 0.005 μM. 18505284
HT29 Cytotoxicity assay 72 hrs Cytotoxicity against human HT29 cells after 72 hrs by MTT assay in presence of 2 uM dicoumarol, IC50 = 2.1 μM. 18222567
HT29 Cytotoxicity assay 72 hrs Cytotoxicity against human HT29 cells after 72 hrs by MTT assay, IC50 = 0.9 μM. 18222567
MCF7 Cytotoxicity assay 24 hrs Cytotoxicity against human MCF7 cells after 24 hrs, IC50 = 5 μM. 18037301
A549 Cytotoxicity assay 24 hrs Cytotoxicity against human A549 cells after 24 hrs, IC50 = 4.5 μM. 18037301
MCF7 Cytotoxicity assay 72 hrs Cytotoxicity against human MCF7 cells after 72 hrs, IC50 = 1.2 μM. 18037301
A549 Cytotoxicity assay 72 hrs Cytotoxicity against human A549 cells after 72 hrs, IC50 = 0.24 μM. 18037301
MCF7 Cytotoxicity assay 3 days Cytotoxicity against human MCF7 cells after 3 days by SRB assay, IC50 = 1.5 μM. 16038545
HCT8 Cytotoxicity assay 3 days Cytotoxicity against human HCT8 cells after 3 days by SRB assay, IC50 = 0.6 μM. 16038545
KB Cytotoxicity assay 3 days Cytotoxicity against human KB cells after 3 days by SRB assay, IC50 = 0.6 μM. 16038545
A549 Cytotoxicity assay 3 days Cytotoxicity against human A549 cells after 3 days by SRB assay, IC50 = 0.3 μM. 16038545
HeLa Cytotoxicity assay 5 to 8 days Cytotoxicity against human HeLa cells assessed as inhibition of colony formation after 5 to 8 days by colony assay, IC50 = 0.068 μM. 11975488
EMT6 Function assay 1 hr Compound is measured for surviving fractions of EMT6 tumor cells treated in culture with (0.50 uM) concentration for 1 hr under aerobic condition., ED50 = 0.7 μM. 7452674
EMT6 Function assay 1 hr Compound is measured for surviving fractions of EMT6 tumor cells treated in culture with (0.50 uM) concentration for 1 hr under hypoxic condition., ED50 = 0.001 μM. 7452674
L1210 Growth inhibition assay 1 hr Inhibition of L1210 leukemia cells, after exposure to compound for period of 1 hr, ID50 = 3.1 μM. 3397995
L1210 Growth inhibition assay 8-9 hrs Inhibition of L1210 leukemia cells, after exposure to compound for period of 8-9 hr, ID50 = 0.18 μM. 3397995
AA8 Function assay 4 hrs Inhibitory activity of compound for AA8 cells to reduce cell density by 50% (exposed to compound for 4 hours), IC50 = 0.00108 μM. 2909741
P388 Antiproliferative assay 48 hrs Antiproliferative activity against mouse P388 cells after 48 hrs by MTT assay, IC50 = 3 μM. 2778449
HT-29 Antiproliferative assay 96 hrs Antiproliferative activity against human HT-29 cells after 96 hrs by MTT assay, IC50 = 0.099 μM. 2778449
Human Caki-1 Renal CellCarcinoma Cell Function assay 96 h Inhibitory concentration against Human Caki-1 Renal CellCarcinoma Cell Lines (CD70+) at 96th hour, ic50=40 nM 15743178
human colon cancer cell line HCT15 Cytotoxic assay 72 h In vitro cytotoxic activity against human colon cancer cell line HCT15 after 72 hr of drug exposure determined by the SRB assay, IC50=70 nM 14980672
MPC5 Antiproliferative assay 72 hrs Antiproliferative activity against human MPC5 cells after 72 hrs by trypan blue exclusion assay, EC50 = 2.1 μM. 19674905
PC3 Growth inhibition assay 48 hrs Growth inhibition of human PC3 cells after 48 hrs by sulforhodamine B assay, IC50 = 1.5 μM. 19939522
Hep2 Growth inhibition assay 48 hrs Growth inhibition of human Hep2 cells after 48 hrs by sulforhodamine B assay, IC50 = 1.5 μM. 19939522
Daudi Growth inhibition assay 24 to 72 hrs Growth inhibition of human Daudi cells after 24 to 72 hrs by MTT assay, IC50 = 0.45 μM. 20117936
K562 Growth inhibition assay 24 to 72 hrs Growth inhibition of human K562 cells after 24 to 72 hrs by MTT assay, IC50 = 0.47 μM. 20117936
K562-Lucena 1 Growth inhibition assay 24 to 72 hrs Growth inhibition of human K562-Lucena 1 cells after 24 to 72 hrs by MTT assay, IC50 = 2.75 μM. 20117936
PBMC Growth inhibition assay 24 to 72 hrs Growth inhibition of phytohemagglutinin-activated human PBMC cells after 24 to 72 hrs by MTT assay, IC50 = 4.03 μM. 20117936
GM00637 Cytotoxicity assay 24 hrs Cytotoxicity against human GM00637 cells after 24 hrs by MTT assay, IC50 = 0.9 μM. 20122765
DU145 Cytotoxicity assay 72 hrs Cytotoxicity against human DU145 cells after 72 hrs by MTT assay, IC50 = 0.17 μM. 20605274
HeLa Cytotoxicity assay 72 hrs Cytotoxicity against human HeLa cells after 72 hrs by MTT assay, IC50 = 0.27 μM. 20605274
GM00637 Cytotoxicity assay 72 hrs Cytotoxicity against human GM00637 cells after 72 hrs by MTT assay, IC50 = 0.46 μM. 20605274
DU145 Cytotoxicity assay 72 hrs Cytotoxicity against human DU145 cells assessed as reduction in mean cell viability after 72 hrs by MTT assay, IC50 = 0.17 μM. 22522008
HeLa Cytotoxicity assay 72 hrs Cytotoxicity against human HeLa cells assessed as reduction in mean cell viability after 72 hrs by MTT assay, IC50 = 0.27 μM. 22522008
GM00637 Cytotoxicity assay 72 hrs Cytotoxicity against human GM00637 cells assessed as reduction in mean cell viability after 72 hrs by MTT assay, IC50 = 0.46 μM. 22522008
HL60 Cytotoxicity assay 72 hrs Cytotoxicity against human HL60 cells after 72 hrs by WST8 assay, IC50 = 0.1 μM. 22537363
HL60 Cytotoxicity assay 48 hrs Cytotoxicity against human HL60 cells after 48 hrs by SRB assay, IC50 = 1.8 μM. 22642381
HeLa Cytotoxicity assay 48 hrs Cytotoxicity against human HeLa cells after 48 hrs by SRB assay, IC50 = 3.4 μM. 22642381
SMMC7721 Cytotoxicity assay 48 hrs Cytotoxicity against human SMMC7721 cells after 48 hrs by SRB assay, IC50 = 5.6 μM. 22642381
A549 Cytotoxicity assay 72 hrs Cytotoxicity against human A549 cells after 72 hrs by alamar blue assay, IC50 = 0.4 μM. 23123017
HCT116 Antiproliferative assay 48 hrs Antiproliferative activity against human HCT116 cells after 48 hrs by sulforhodamine B assay, IC50 = 0.5 μM. 23501113
NCI-H23 Cytotoxicity assay 48 hrs Cytotoxicity against human NCI-H23 cells after 48 hrs by MTT assay, IC50 = 2 μM. 23792352
SPCA1 Cytotoxicity assay 48 hrs Cytotoxicity against human SPCA1 cells after 48 hrs by MTT assay, IC50 = 1.68 μM. 23999045
SGC7901 Cytotoxicity assay 48 hrs Cytotoxicity against human SGC7901 cells after 48 hrs by MTT assay, IC50 = 2.05 μM. 23999045
PC3 Cytotoxicity assay 48 hrs Cytotoxicity against human PC3 cells after 48 hrs by SRB assay, IC50 = 1.5 μM. 24056146
HeLa Cytotoxicity assay 48 hrs Cytotoxicity against human HeLa cells after 48 hrs by SRB assay, IC50 = 2 μM. 24056146
MDA-MB-231 Cytotoxicity assay 5 days Cytotoxicity against human MDA-MB-231 cells overexpressing DT-diaphorase after 5 days, EC50 = 0.103 μM. 24436995
MDA-MB-231 Cytotoxicity assay 5 days Cytotoxicity against wild-type human MDA-MB-231 cells after 5 days, EC50 = 1.25 μM. 24436995
HCT15 Cytotoxicity assay 48 hrs Cytotoxicity against human HCT15 cells after 48 hrs by sulforhodamine B assay, IC50 = 0.5 μM. 24910974
HeLa Cytotoxicity assay 48 hrs Cytotoxicity against human HeLa cells after 48 hrs by SRB method, IC50 = 3 μM. 24913558
SMMC-7221 Cytotoxicity assay 48 hrs Cytotoxicity against human SMMC-7221 cells after 48 hrs by SRB method, IC50 = 3 μM. 24913558
HL60 Cytotoxicity assay 48 hrs Cytotoxicity against human HL60 cells after 48 hrs by SRB method, IC50 = 3 μM. 24913558
PC3 Cytotoxicity assay 48 hrs Cytotoxicity against human PC3 cells after 48 hrs by SRB assay, IC50 = 1.5 μM. 25176329
HeLa Cytotoxicity assay 48 hrs Cytotoxicity against human HeLa cells after 48 hrs by SRB assay, IC50 = 2 μM. 25176329
A549 Cytotoxicity assay 48 hrs Cytotoxicity against human A549 cells after 48 hrs by SRB assay, IC50 = 0.04 μM. 25259515
THP1 Cytotoxicity assay 48 hrs Cytotoxicity against human THP1 cells after 48 hrs by SRB assay, IC50 = 0.1 μM. 25259515
MCF7 Cytotoxicity assay 48 hrs Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay, IC50 = 0.2 μM. 25259515
A549 Cytotoxicity assay 24 hrs Cytotoxicity against human A549 cells assessed as reduction in cell viability after 24 hrs by WST8 assay, IC50 = 0.45 μM. 25442306
SF539 Cytotoxicity assay 72 hrs Cytotoxicity against human SF539 cells after 72 hrs by MTS assay, IC50 = 0.038 μM. 26335269
M14 Cytotoxicity assay 72 hrs Cytotoxicity against human M14 cells after 72 hrs by MTS assay, IC50 = 0.47 μM. 26335269
MDA-MB-468 Cytotoxicity assay 72 hrs Cytotoxicity against human MDA-MB-468 cells after 72 hrs by MTS assay, IC50 = 0.5 μM. 26335269
SF295 Cytotoxicity assay 72 hrs Cytotoxicity against human SF295 cells after 72 hrs by MTS assay, IC50 = 0.54 μM. 26335269
NCI-H226 Cytotoxicity assay 72 hrs Cytotoxicity against human NCI-H226 cells after 72 hrs by MTS assay, IC50 = 0.58 μM. 26335269
A549 Cytotoxicity assay 48 hrs Cytotoxicity against human A549 cells assessed as decrease in cell viability at 10 to 100 uM after 48 hrs by SRB assay, EC50 = 5.2 μM. 26508550
HUT78 Antiproliferative assay 48 hrs Antiproliferative activity against human HUT78 cells after 48 hrs by resazurin reduction assay, IC50 = 0.066 μM. 26541587
Jurkat T Antiproliferative assay 48 hrs Antiproliferative activity against human Jurkat T cells in hypoxic condition after 48 hrs by resazurin reduction assay, IC50 = 0.303 μM. 26541587
HL60 Antiproliferative assay 48 hrs Antiproliferative activity against human HL60 cells after 48 hrs by resazurin reduction assay, IC50 = 0.41 μM. 26541587
Jurkat T Antiproliferative assay 48 hrs Antiproliferative activity against human Jurkat T cells after 48 hrs by resazurin reduction assay, IC50 = 0.578 μM. 26541587
HeLa Antiproliferative assay 48 hrs Antiproliferative activity against human HeLa cells after 48 hrs by resazurin reduction assay, IC50 = 1.87 μM. 26541587
HepG2 Antiproliferative assay 48 hrs Antiproliferative activity against human HepG2 cells after 48 hrs by resazurin reduction assay, IC50 = 2.937 μM. 26541587
T47D Antiproliferative assay 48 hrs Antiproliferative activity against human T47D cells after 48 hrs by resazurin reduction assay, IC50 = 16.97 μM. 26541587
PC3 Cytotoxicity assay 72 hrs Cytotoxicity against human PC3 cells after 72 hrs by CCK-8 assay, IC50 = 1.4 μM. 26615890
A549 Cytotoxicity assay 72 hrs Cytotoxicity against human A549 cells after 72 hrs by CCK-8 assay, IC50 = 1.7 μM. 26615890
HT-29 Antiproliferative assay 72 hrs Antiproliferative activity against human HT-29 cells expressing NQO1 after 72 hrs by MTT assay, IC50 = 7.099 μM. 28395199
NCI-H596 Antiproliferative assay 72 hrs Antiproliferative activity against NQO1 deficient human NCI-H596 cells after 72 hrs by MTT assay, IC50 = 11.969 μM. 28395199
A549 Antiproliferative assay 72 hrs Antiproliferative activity against human A549 cells expressing NQO1 after 72 hrs by MTT assay, IC50 = 15.525 μM. 28395199
LO2 Cytotoxicity assay 72 hrs Cytotoxicity against human LO2 cells after 72 hrs by MTT assay, IC50 = 25.023 μM. 28395199
CHOK1 Cytotoxicity assay 24 hrs Cytotoxicity against CHOK1 cells incubated for 24 hrs by MTT asasy, IC50 = 13.2 μM. 28615134
A549 Growth inhibition assay 72 hrs Growth inhibition of human A549 cells after 72 hrs by Cell-Titer Glo assay, GI50 = 0.08 μM. 28682609
SKOV3 Growth inhibition assay 72 hrs Growth inhibition of human SKOV3 cells after 72 hrs by Cell-Titer Glo assay, GI50 = 0.1 μM. 28682609
HCT116 Growth inhibition assay 72 hrs Growth inhibition of human HCT116 cells after 72 hrs by Cell-Titer Glo assay, GI50 = 0.2 μM. 28682609
786-O Growth inhibition assay 72 hrs Growth inhibition of human 786-O cells after 72 hrs by Cell-Titer Glo assay, GI50 = 0.21 μM. 28682609
BxPC3 Growth inhibition assay 72 hrs Growth inhibition of human BxPC3 cells after 72 hrs by Cell-Titer Glo assay, GI50 = 0.38 μM. 28682609
HEC6 Growth inhibition assay 72 hrs Growth inhibition of human HEC6 cells after 72 hrs by Cell-Titer Glo assay, GI50 = 1.4 μM. 28682609
MKN74 Growth inhibition assay 72 hrs Growth inhibition of human MKN74 cells after 72 hrs by Cell-Titer Glo assay, GI50 = 1.7 μM. 28682609
U87MG Growth inhibition assay 72 hrs Growth inhibition of human U87MG cells after 72 hrs by Cell-Titer Glo assay, GI50 = 1.8 μM. 28682609
HuH7 Growth inhibition assay 72 hrs Growth inhibition of human HuH7 cells after 72 hrs by Cell-Titer Glo assay, GI50 = 2 μM. 28682609
MCF7 Growth inhibition assay 72 hrs Growth inhibition of human MCF7 cells after 72 hrs by Cell-Titer Glo assay, GI50 = 2.5 μM. 28682609
MDA-MB-231 Antiproliferative assay 48 hrs Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay, IC50 = 4.4 μM. 29280632
HL60 Antiproliferative assay 48 hrs Antiproliferative activity against human HL60 cells after 48 hrs by CCK8 assay, IC50 = 0.19 μM. 29475587
HeLa Antiproliferative assay 48 hrs Antiproliferative activity against human HeLa cells after 48 hrs by CCK8 assay, IC50 = 1.13 μM. 29475587
Daoy Cytotoxicity assay Cytotoxicity against human Daoy cells by MTT assay, ED50 = 0.21 μM. 19061391
WiDr Cytotoxicity assay Cytotoxicity against human WiDr cells by MTT assay, ED50 = 0.18 μM. 19061391
A549 Cytotoxicity assay Cytotoxicity against human A549 cells by Alamar blue assay, IC50 = 0.4 μM. 18037301
MCF7 Cytotoxicity assay Cytotoxicity against human MCF7 cells by Alamar blue assay, IC50 = 0.2 μM. 18037301
MPC5 Cytotoxicity assay Cytotoxicity against human MPC5 cells assessed as cell viability by tryptan blue staining method, EC50 = 2.1 μM. 17950604
IE Cytotoxicity assay Cytotoxicity against human IE cells assessed as cell viability by tryptan blue staining method, EC50 = 1.46 μM. 17950604
Hc Cytotoxicity assay Cytotoxicity against human Hc cells assessed as cell viability by tryptan blue staining method, EC50 = 1.46 μM. 17950604
MCF7 Cytotoxicity assay Cytotoxicity against human MCF7 cells assessed as cell viability by tryptan blue staining method, EC50 = 0.96 μM. 17950604
Fb Cytotoxicity assay Cytotoxicity against human Fb cells assessed as cell viability by tryptan blue staining method, EC50 = 0.93 μM. 17950604
A549 Cytotoxicity assay Cytotoxicity against human A549 cells assessed as cell viability by tryptan blue staining method, EC50 = 0.43 μM. 17950604
PC3 Cytotoxicity assay Cytotoxicity against human PC3 cells assessed as cell viability by tryptan blue staining method, EC50 = 0.14 μM. 17950604
KATO III Cytotoxicity assay Cytotoxicity against human KATO III cells by MTT assay, ED50 = 49 μM. 12880314
SCL6 Cytotoxicity assay Cytotoxicity against human SCL6 cells by MTT assay, ED50 = 20.7 μM. 12880314
SCL Cytotoxicity assay Cytotoxicity against human SCL cells by MTT assay, ED50 = 20.2 μM. 12880314
NUGC4 Cytotoxicity assay Cytotoxicity against human NUGC4 cells by MTT assay, ED50 = 19.1 μM. 12880314
SCL37'6 Cytotoxicity assay Cytotoxicity against human SCL37'6 cells by MTT assay, ED50 = 19 μM. 12880314
SCL9 Cytotoxicity assay Cytotoxicity against human SCL9 cells by MTT assay, ED50 = 17.4 μM. 12880314
K562 Function assay In vitro inhibitory activity against K562 leukemia cells in the presence of pd2, IC50 = 0.0158 μM. 12699386
K562 Function assay In vitro inhibitory activity against K562 leukemia cells, IC50 = 0.001 μM. 12699386
colon cancer cell Cytotoxicity assay Cytotoxicity against human colon cancer cells, GI50 = 0.18 μM. 11473418
ovarian cancer cell Cytotoxicity assay Cytotoxicity against human ovarian cancer cells, GI50 = 0.12 μM. 11473418
stomach cancer cell Cytotoxicity assay Cytotoxicity against human stomach cancer cells, GI50 = 0.1 μM. 11473418
CNS cancer cell Cytotoxicity assay Cytotoxicity against human CNS cancer cells, GI50 = 0.064 μM. 11473418
breast cancer cell Cytotoxicity assay Cytotoxicity against human breast cancer cells, GI50 = 0.034 μM. 11473418
lung cancer cell Cytotoxicity assay Cytotoxicity against human lung cancer cells, GI50 = 0.023 μM. 11473418
MCF-7 Antiproliferative assay Antiproliferative activity of compound was evaluated on MCF-7 cells from human breast adenocarcinoma, ID50 = 42.92 μM. 11012027
Molt3 Antiproliferative assay Antiproliferative activity of compound was evaluated on Molt3 cells from human lymphoblastic leukemia, ID50 = 2.66 μM. 11012027
SupT1 Antiproliferative assay Antiproliferative activity of compound was evaluated on SupT1 cells from human non-Hodgkin lymphoma, ID50 = 0.7 μM. 11012027
aerobic cell Function assay In vitro concentration required to kill 50% of the aerobic cells, C50 = 0.8 μM. 9240349
V79-379A Function assay In vitro concentration required to kill hypoxic cells V79-379A cells, C50 = 0.4 μM. 9240349
DC-3F/AD-II Growth inhibition assay Inhibition of cell growth was studied in chinese hamster lung cells resistant to actinomycin D (DC-3F/AD-II)., IC50 = 0.11 μM. 8709111
DC-3F Growth inhibition assay Inhibition of cell growth was studied in chinese hamster lung cells (DC-3F), IC50 = 0.082 μM. 8709111
HL-60 Growth inhibition assay Inhibition of cell growth was studied in human promyelocytic leukemic (HL-60) cells., IC50 = 0.05 μM. 8709111
P388 Function assay Evaluation of inhibitory activity against multidrug resistant P388 cells (P388/ADR) cells, IC50 = 0.535 μM. 8544183
P388 Function assay Evaluation of inhibitory activity against drug sensitive P388 cells (P388/S) cells, IC50 = 0.048 μM. 8544183
HeLa S3 Function assay In vitro anticellular activity against HeLa S3 cells, IC50 = 0.59 μM. 8021919
HeLa S3 Function assay In vitro anticellular activity against HeLa S3 cells; 0.82-1.4, IC50 = 1.4 μM. 8021918
HeLa S3 Function assay In vitro anticellular activity against HeLa S3 cells; 0.59-1.1, IC50 = 1.1 μM. 8021918
V79 Function assay Inhibitory concentration required to kill 50% of the cells was evaluated under aerobic conditions from chinese hamster V79 cells., IC50 = 0.8 μM. 7966141
V79 Function assay Inhibitory concentration required to kill 50% of the cells was evaluated under anaerobic (N2) conditions from chinese hamster V79 cells., IC50 = 0.4 μM. 7966141
P388 Antitumor assay Antitumor potency on P388 leukemia cells in culture, IC50 = 0.0508 μM. 1906109
L1210 Function assay Inhibitory concentration on multidrug-resistant L1210 leukemia cells., IC50 = 1.5 μM. 1906107
L1210 Function assay Inhibitory concentration on parentral (sensitive) L1210 leukemia cells., IC50 = 0.09 μM. 1906107
HeLa Function assay In vitro anticellular activity against HeLa cells., IC50 = 0.81 μM. 1495011
WiDr colon cancer cell Growth inhibition assay In vitro inhibition of WiDr colon cancer cell line, IC50=10 nM 1920349
SW480 colon cancer cell Growth inhibition assay In vitro inhibition of SW480 colon cancer cell line, IC50=7 nM 1920349
human A2780 (ovarian) tumor cell Cytotoxic assay The compound was evaluated for the cytotoxicity against human A2780 (ovarian) tumor cell lines, IC50=50 nM 10698444
human HT-29 (colon) tumor cell Cytotoxic assay The compound was evaluated for the cytotoxicity against human HT-29 (colon) tumor cell lines, IC50=40 nM 10698444
human CH1 (ovarian) tumor cell Cytotoxic assay The compound was evaluated for the cytotoxicity against human CH1 (ovarian) tumor cell lines, IC50=40 nM 10698444
A549 Cytotoxicity assay Cytotoxicity against human A549 cells by MTT assay, IC50 = 3 μM. 22545792
A549 Cytotoxicity assay Cytotoxicity against human A549 cells, IC50 = 0.5 μM. 27089214
PC3 Cytotoxicity assay Cytotoxicity against human PC3 cells, IC50 = 0.5 μM. 27089214
NTERA-S-cl-D1 Growth inhibition assay IC50 = 0.0221 nM SANGER
MOLT-4 Growth inhibition assay IC50 = 0.0325 nM SANGER
J82 Growth inhibition assay IC50 = 0.119 nM SANGER
697 Growth inhibition assay IC50 = 0.1283 nM SANGER
KYSE-510 Growth inhibition assay IC50 = 0.1486 nM SANGER
NCI-H2170 Growth inhibition assay IC50 = 0.1513 nM SANGER
BE-13 Growth inhibition assay IC50 = 0.1673 nM SANGER
LC-2-ad Growth inhibition assay IC50 = 0.2492 nM SANGER
IMR-5 Growth inhibition assay IC50 = 0.3076 nM SANGER
EW-16 Growth inhibition assay IC50 = 0.31 nM SANGER
MC-IXC Growth inhibition assay IC50 = 0.638 nM SANGER
SW872 Growth inhibition assay IC50 = 0.676 nM SANGER
NCI-H2228 Growth inhibition assay IC50 = 0.7963 nM SANGER
NALM-6 Growth inhibition assay IC50 = 1.066 nM SANGER
ES4 Growth inhibition assay IC50 = 1.555 nM SANGER
KE-37 Growth inhibition assay IC50 = 1.636 nM SANGER
IST-MEL1 Growth inhibition assay IC50 = 1.684 nM SANGER
ES8 Growth inhibition assay IC50 = 1.712 nM SANGER
MV-4-11 Growth inhibition assay IC50 = 1.732 nM SANGER
639-V Growth inhibition assay IC50 = 1.759 nM SANGER
OCI-AML2 Growth inhibition assay IC50 = 1.886 nM SANGER
SK-LU-1 Growth inhibition assay IC50 = 2.217 nM SANGER
REH Growth inhibition assay IC50 = 2.548 nM SANGER
PSN1 Growth inhibition assay IC50 = 2.554 nM SANGER
SBC-5 Growth inhibition assay IC50 = 2.589 nM SANGER
HT-3 Growth inhibition assay IC50 = 2.928 nM SANGER
SIG-M5 Growth inhibition assay IC50 = 3.524 nM SANGER
ES7 Growth inhibition assay IC50 = 3.653 nM SANGER
CHP-212 Growth inhibition assay IC50 = 4.368 nM SANGER
P12-ICHIKAWA Growth inhibition assay IC50 = 4.787 nM SANGER
HUTU-80 Growth inhibition assay IC50 = 4.83 nM SANGER
P30-OHK Growth inhibition assay IC50 = 4.842 nM SANGER
NCI-H1651 Growth inhibition assay IC50 = 4.99 nM SANGER
COR-L279 Growth inhibition assay IC50 = 5.545 nM SANGER
CMK Growth inhibition assay IC50 = 5.827 nM SANGER
MHH-CALL-2 Growth inhibition assay IC50 = 6.06 nM SANGER
BV-173 Growth inhibition assay IC50 = 6.067 nM SANGER
NCI-H209 Growth inhibition assay IC50 = 6.168 nM SANGER
NCI-H460 Growth inhibition assay IC50 = 6.452 nM SANGER
DU-145 Growth inhibition assay IC50 = 6.519 nM SANGER
769-P Growth inhibition assay IC50 = 7.112 nM SANGER
ES1 Growth inhibition assay IC50 = 7.288 nM SANGER
COLO-668 Growth inhibition assay IC50 = 7.545 nM SANGER
NKM-1 Growth inhibition assay IC50 = 7.831 nM SANGER
ES3 Growth inhibition assay IC50 = 7.882 nM SANGER
SCC-3 Growth inhibition assay IC50 = 8.519 nM SANGER
SU-DHL-1 Growth inhibition assay IC50 = 8.609 nM SANGER
ML-2 Growth inhibition assay IC50 = 8.781 nM SANGER
SF295 Growth inhibition assay IC50 = 11.48 nM SANGER
EW-7 Growth inhibition assay IC50 = 12.14 nM SANGER
H4 Growth inhibition assay IC50 = 12.44 nM SANGER
LB2241-RCC Growth inhibition assay IC50 = 13.19 nM SANGER
SR Growth inhibition assay IC50 = 13.46 nM SANGER
LB1047-RCC Growth inhibition assay IC50 = 13.6 nM SANGER
MCF7 Growth inhibition assay IC50 = 13.9 nM SANGER
ESS-1 Growth inhibition assay IC50 = 13.92 nM SANGER
NCI-H2122 Growth inhibition assay IC50 = 13.96 nM SANGER
786-0 Growth inhibition assay IC50 = 14.01 nM SANGER
COLO-205 Growth inhibition assay IC50 = 14.33 nM SANGER
HAL-01 Growth inhibition assay IC50 = 15.73 nM SANGER
MHH-ES-1 Growth inhibition assay IC50 = 16.26 nM SANGER
NUGC-3 Growth inhibition assay IC50 = 16.95 nM SANGER
RPMI-8402 Growth inhibition assay IC50 = 17.13 nM SANGER
ATN-1 Growth inhibition assay IC50 = 17.39 nM SANGER
NCI-H441 Growth inhibition assay IC50 = 17.6 nM SANGER
LB996-RCC Growth inhibition assay IC50 = 17.68 nM SANGER
CAL-148 Growth inhibition assay IC50 = 17.83 nM SANGER
CTV-1 Growth inhibition assay IC50 = 18.67 nM SANGER
HOP-62 Growth inhibition assay IC50 = 20.2 nM SANGER
CAKI-1 Growth inhibition assay IC50 = 23.32 nM SANGER
PA-1 Growth inhibition assay IC50 = 23.51 nM SANGER
HT-144 Growth inhibition assay IC50 = 23.75 nM SANGER
LOUCY Growth inhibition assay IC50 = 26.19 nM SANGER
BPH-1 Growth inhibition assay IC50 = 29.9 nM SANGER
LS-1034 Growth inhibition assay IC50 = 30.16 nM SANGER
23132-87 Growth inhibition assay IC50 = 30.53 nM SANGER
BB30-HNC Growth inhibition assay IC50 = 30.61 nM SANGER
CAL-51 Growth inhibition assay IC50 = 30.86 nM SANGER
ALL-PO Growth inhibition assay IC50 = 30.98 nM SANGER
5637 Growth inhibition assay IC50 = 31.93 nM SANGER
KYSE-150 Growth inhibition assay IC50 = 34.09 nM SANGER
RS4-11 Growth inhibition assay IC50 = 34.86 nM SANGER
A3-KAW Growth inhibition assay IC50 = 34.96 nM SANGER
NCI-H719 Growth inhibition assay IC50 = 35.12 nM SANGER
GI-1 Growth inhibition assay IC50 = 35.16 nM SANGER
HEL Growth inhibition assay IC50 = 35.8 nM SANGER
TE-8 Growth inhibition assay IC50 = 35.86 nM SANGER
HT-29 Growth inhibition assay IC50 = 36.02 nM SANGER
SW1783 Growth inhibition assay IC50 = 38.58 nM SANGER
CGTH-W-1 Growth inhibition assay IC50 = 38.74 nM SANGER
MEL-HO Growth inhibition assay IC50 = 39.4 nM SANGER
SW620 Growth inhibition assay IC50 = 39.79 nM SANGER
ME-180 Growth inhibition assay IC50 = 40.11 nM SANGER
CAL-27 Growth inhibition assay IC50 = 41.18 nM SANGER
A431 Growth inhibition assay IC50 = 43.77 nM SANGER
SW954 Growth inhibition assay IC50 = 44.91 nM SANGER
CAL-39 Growth inhibition assay IC50 = 46.49 nM SANGER
LU-134-A Growth inhibition assay IC50 = 46.72 nM SANGER
DU-4475 Growth inhibition assay IC50 = 47.47 nM SANGER
DEL Growth inhibition assay IC50 = 48.39 nM SANGER
HGC-27 Growth inhibition assay IC50 = 49.29 nM SANGER
RH-1 Growth inhibition assay IC50 = 49.57 nM SANGER
SK-MES-1 Growth inhibition assay IC50 = 51.12 nM SANGER
MEL-JUSO Growth inhibition assay IC50 = 51.25 nM SANGER
VA-ES-BJ Growth inhibition assay IC50 = 52.16 nM SANGER
EW-13 Growth inhibition assay IC50 = 52.51 nM SANGER
Ca-Ski Growth inhibition assay IC50 = 53.75 nM SANGER
LXF-289 Growth inhibition assay IC50 = 55.37 nM SANGER
IM-9 Growth inhibition assay IC50 = 56.22 nM SANGER
HCE-4 Growth inhibition assay IC50 = 57.94 nM SANGER
TYK-nu Growth inhibition assay IC50 = 58.73 nM SANGER
NCI-H748 Growth inhibition assay IC50 = 59.54 nM SANGER
ABC-1 Growth inhibition assay IC50 = 61.2 nM SANGER
CCRF-CEM Growth inhibition assay IC50 = 61.68 nM SANGER
EW-3 Growth inhibition assay IC50 = 61.95 nM SANGER
NCI-H2342 Growth inhibition assay IC50 = 62.51 nM SANGER
SK-PN-DW Growth inhibition assay IC50 = 63.76 nM SANGER
EB2 Growth inhibition assay IC50 = 65.36 nM SANGER
CAL-85-1 Growth inhibition assay IC50 = 65.88 nM SANGER
NCI-H526 Growth inhibition assay IC50 = 67.37 nM SANGER
MFH-ino Growth inhibition assay IC50 = 70.61 nM SANGER
ACHN Growth inhibition assay IC50 = 72.08 nM SANGER
MONO-MAC-6 Growth inhibition assay IC50 = 72.35 nM SANGER
CHP-126 Growth inhibition assay IC50 = 72.44 nM SANGER
SW1710 Growth inhibition assay IC50 = 72.58 nM SANGER
TE-10 Growth inhibition assay IC50 = 72.6 nM SANGER
TE-15 Growth inhibition assay IC50 = 73.7 nM SANGER
PANC-10-05 Growth inhibition assay IC50 = 73.75 nM SANGER
BHY Growth inhibition assay IC50 = 75.28 nM SANGER
HSC-3 Growth inhibition assay IC50 = 75.54 nM SANGER
COLO-800 Growth inhibition assay IC50 = 78.66 nM SANGER
NB10 Growth inhibition assay IC50 = 81.65 nM SANGER
SK-UT-1 Growth inhibition assay IC50 = 82.8 nM SANGER
HSC-2 Growth inhibition assay IC50 = 83.42 nM SANGER
GP5d Growth inhibition assay IC50 = 84 nM SANGER
A204 Growth inhibition assay IC50 = 84.19 nM SANGER
BFTC-909 Growth inhibition assay IC50 = 85.27 nM SANGER
NCI-H2087 Growth inhibition assay IC50 = 85.69 nM SANGER
G-402 Growth inhibition assay IC50 = 85.92 nM SANGER
647-V Growth inhibition assay IC50 = 87.39 nM SANGER
Daoy Growth inhibition assay IC50 = 88.01 nM SANGER
EW-1 Growth inhibition assay IC50 = 88.07 nM SANGER
BC-1 Growth inhibition assay IC50 = 88.81 nM SANGER
OAW-42 Growth inhibition assay IC50 = 89.42 nM SANGER
COLO-679 Growth inhibition assay IC50 = 90.25 nM SANGER
TE-11 Growth inhibition assay IC50 = 91.77 nM SANGER
BFTC-905 Growth inhibition assay IC50 = 92.69 nM SANGER
KP-4 Growth inhibition assay IC50 = 93.15 nM SANGER
DOHH-2 Growth inhibition assay IC50 = 93.83 nM SANGER
L-540 Growth inhibition assay IC50 = 95.14 nM SANGER
DSH1 Growth inhibition assay IC50 = 96.53 nM SANGER
M059J Growth inhibition assay IC50 = 100.6 nM SANGER
UM-UC-3 Growth inhibition assay IC50 = 101.83 nM SANGER
ES5 Growth inhibition assay IC50 = 102.42 nM SANGER
KYSE-270 Growth inhibition assay IC50 = 102.84 nM SANGER
OCUB-M Growth inhibition assay IC50 = 102.98 nM SANGER
C-4-II Growth inhibition assay IC50 = 103.51 nM SANGER
BOKU Growth inhibition assay IC50 = 103.78 nM SANGER
8-MG-BA Growth inhibition assay IC50 = 104 nM SANGER
SW982 Growth inhibition assay IC50 = 104.73 nM SANGER
AGS Growth inhibition assay IC50 = 105.8 nM SANGER
IGROV-1 Growth inhibition assay IC50 = 105.97 nM SANGER
HL-60 Growth inhibition assay IC50 = 106.06 nM SANGER
A2780 Growth inhibition assay IC50 = 106.63 nM SANGER
HOS Growth inhibition assay IC50 = 106.7 nM SANGER
HuP-T4 Growth inhibition assay IC50 = 108.1 nM SANGER
ETK-1 Growth inhibition assay IC50 = 108.24 nM SANGER
IA-LM Growth inhibition assay IC50 = 108.63 nM SANGER
MRK-nu-1 Growth inhibition assay IC50 = 110.25 nM SANGER
SUP-T1 Growth inhibition assay IC50 = 110.4 nM SANGER
A2058 Growth inhibition assay IC50 = 115.1 nM SANGER
CAPAN-1 Growth inhibition assay IC50 = 116.4 nM SANGER
NCI-H1355 Growth inhibition assay IC50 = 116.8 nM SANGER
NCI-H1618 Growth inhibition assay IC50 = 117.76 nM SANGER
QIMR-WIL Growth inhibition assay IC50 = 119.58 nM SANGER
HCC1599 Growth inhibition assay IC50 = 120.17 nM SANGER
GR-ST Growth inhibition assay IC50 = 121.34 nM SANGER
G-361 Growth inhibition assay IC50 = 123.93 nM SANGER
RKO Growth inhibition assay IC50 = 125.29 nM SANGER
NCI-H1437 Growth inhibition assay IC50 = 126.26 nM SANGER
SF539 Growth inhibition assay IC50 = 127.02 nM SANGER
ACN Growth inhibition assay IC50 = 127.91 nM SANGER
FADU Growth inhibition assay IC50 = 128.29 nM SANGER
U251 Growth inhibition assay IC50 = 128.73 nM SANGER
KALS-1 Growth inhibition assay IC50 = 129.14 nM SANGER
KM-H2 Growth inhibition assay IC50 = 130.45 nM SANGER
SJSA-1 Growth inhibition assay IC50 = 131.56 nM SANGER
TE-5 Growth inhibition assay IC50 = 132.24 nM SANGER
SNG-M Growth inhibition assay IC50 = 134.17 nM SANGER
HCC1806 Growth inhibition assay IC50 = 134.54 nM SANGER
NCI-H1734 Growth inhibition assay IC50 = 136.85 nM SANGER
LCLC-97TM1 Growth inhibition assay IC50 = 138.72 nM SANGER
NH-12 Growth inhibition assay IC50 = 139.13 nM SANGER
A375 Growth inhibition assay IC50 = 139.42 nM SANGER
NCI-SNU-5 Growth inhibition assay IC50 = 141.21 nM SANGER
SK-OV-3 Growth inhibition assay IC50 = 142.64 nM SANGER
22RV1 Growth inhibition assay IC50 = 144.07 nM SANGER
SW1573 Growth inhibition assay IC50 = 144.68 nM SANGER
BB65-RCC Growth inhibition assay IC50 = 144.71 nM SANGER
MES-SA Growth inhibition assay IC50 = 144.94 nM SANGER
K052 Growth inhibition assay IC50 = 149.34 nM SANGER
KU812 Growth inhibition assay IC50 = 149.96 nM SANGER
NOMO-1 Growth inhibition assay IC50 = 151.41 nM SANGER
Ca9-22 Growth inhibition assay IC50 = 155.57 nM SANGER
8305C Growth inhibition assay IC50 = 155.75 nM SANGER
NCI-SNU-1 Growth inhibition assay IC50 = 156.24 nM SANGER
HC-1 Growth inhibition assay IC50 = 156.51 nM SANGER
SW962 Growth inhibition assay IC50 = 157.55 nM SANGER
HCC2998 Growth inhibition assay IC50 = 160.13 nM SANGER
DMS-273 Growth inhibition assay IC50 = 160.83 nM SANGER
MC-CAR Growth inhibition assay IC50 = 160.91 nM SANGER
Caov-3 Growth inhibition assay IC50 = 161.72 nM SANGER
EoL-1-cell Growth inhibition assay IC50 = 162.39 nM SANGER
MKN45 Growth inhibition assay IC50 = 165.04 nM SANGER
TE-1 Growth inhibition assay IC50 = 165.38 nM SANGER
HMV-II Growth inhibition assay IC50 = 166.06 nM SANGER
SK-NEP-1 Growth inhibition assay IC50 = 166.53 nM SANGER
PANC-03-27 Growth inhibition assay IC50 = 167.16 nM SANGER
RPMI-7951 Growth inhibition assay IC50 = 167.55 nM SANGER
NCI-H520 Growth inhibition assay IC50 = 168.65 nM SANGER
NCI-H522 Growth inhibition assay IC50 = 169.45 nM SANGER
Detroit562 Growth inhibition assay IC50 = 170.26 nM SANGER
SF268 Growth inhibition assay IC50 = 170.86 nM SANGER
T84 Growth inhibition assay IC50 = 173.34 nM SANGER
NB69 Growth inhibition assay IC50 = 175.06 nM SANGER
OVCAR-8 Growth inhibition assay IC50 = 175.54 nM SANGER
RT-112 Growth inhibition assay IC50 = 177.98 nM SANGER
DoTc2-4510 Growth inhibition assay IC50 = 180.37 nM SANGER
J-RT3-T3-5 Growth inhibition assay IC50 = 185.8 nM SANGER
NB1 Growth inhibition assay IC50 = 186.61 nM SANGER
NEC8 Growth inhibition assay IC50 = 186.77 nM SANGER
TUR Growth inhibition assay IC50 = 189.67 nM SANGER
TE-12 Growth inhibition assay IC50 = 189.83 nM SANGER
WSU-NHL Growth inhibition assay IC50 = 192.04 nM SANGER
MHH-NB-11 Growth inhibition assay IC50 = 192.55 nM SANGER
SW48 Growth inhibition assay IC50 = 193.36 nM SANGER
C3A Growth inhibition assay IC50 = 194.31 nM SANGER
RPMI-2650 Growth inhibition assay IC50 = 195.75 nM SANGER
VMRC-RCZ Growth inhibition assay IC50 = 198.77 nM SANGER
SK-CO-1 Growth inhibition assay IC50 = 0.20181 μM SANGER
KYSE-180 Growth inhibition assay IC50 = 0.20219 μM SANGER
KGN Growth inhibition assay IC50 = 0.20713 μM SANGER
A388 Growth inhibition assay IC50 = 0.20722 μM SANGER
NCI-H2030 Growth inhibition assay IC50 = 0.21132 μM SANGER
NCI-H727 Growth inhibition assay IC50 = 0.2118 μM SANGER
BC-3 Growth inhibition assay IC50 = 0.21208 μM SANGER
CCF-STTG1 Growth inhibition assay IC50 = 0.21559 μM SANGER
NMC-G1 Growth inhibition assay IC50 = 0.21675 μM SANGER
NCI-H1299 Growth inhibition assay IC50 = 0.21841 μM SANGER
RPMI-6666 Growth inhibition assay IC50 = 0.21961 μM SANGER
D-283MED Growth inhibition assay IC50 = 0.22069 μM SANGER
AM-38 Growth inhibition assay IC50 = 0.22116 μM SANGER
LU-99A Growth inhibition assay IC50 = 0.22424 μM SANGER
KYSE-70 Growth inhibition assay IC50 = 0.22431 μM SANGER
CHL-1 Growth inhibition assay IC50 = 0.22516 μM SANGER
CESS Growth inhibition assay IC50 = 0.2254 μM SANGER
A4-Fuk Growth inhibition assay IC50 = 0.22543 μM SANGER
MG-63 Growth inhibition assay IC50 = 0.22618 μM SANGER
MKN28 Growth inhibition assay IC50 = 0.23009 μM SANGER
NCI-H1417 Growth inhibition assay IC50 = 0.2369 μM SANGER
BCPAP Growth inhibition assay IC50 = 0.2396 μM SANGER
COR-L23 Growth inhibition assay IC50 = 0.24094 μM SANGER
SIMA Growth inhibition assay IC50 = 0.24142 μM SANGER
CAL-62 Growth inhibition assay IC50 = 0.24185 μM SANGER
ARH-77 Growth inhibition assay IC50 = 0.24331 μM SANGER
COLO-680N Growth inhibition assay IC50 = 0.2441 μM SANGER
T-24 Growth inhibition assay IC50 = 0.24577 μM SANGER
PF-382 Growth inhibition assay IC50 = 0.25063 μM SANGER
NCI-H810 Growth inhibition assay IC50 = 0.25161 μM SANGER
NCI-H1882 Growth inhibition assay IC50 = 0.25709 μM SANGER
A101D Growth inhibition assay IC50 = 0.25745 μM SANGER
NCI-H2126 Growth inhibition assay IC50 = 0.2602 μM SANGER
VM-CUB-1 Growth inhibition assay IC50 = 0.26082 μM SANGER
OS-RC-2 Growth inhibition assay IC50 = 0.2637 μM SANGER
MIA-PaCa-2 Growth inhibition assay IC50 = 0.27545 μM SANGER
SW837 Growth inhibition assay IC50 = 0.27613 μM SANGER
NCI-H358 Growth inhibition assay IC50 = 0.27626 μM SANGER
NCI-H1703 Growth inhibition assay IC50 = 0.27688 μM SANGER
NCI-H1650 Growth inhibition assay IC50 = 0.28257 μM SANGER
SW626 Growth inhibition assay IC50 = 0.28622 μM SANGER
MFE-296 Growth inhibition assay IC50 = 0.28623 μM SANGER
NCI-H2009 Growth inhibition assay IC50 = 0.28857 μM SANGER
NCI-H2405 Growth inhibition assay IC50 = 0.29434 μM SANGER
BL-41 Growth inhibition assay IC50 = 0.2949 μM SANGER
SNU-C2B Growth inhibition assay IC50 = 0.29505 μM SANGER
no-10 Growth inhibition assay IC50 = 0.2996 μM SANGER
A427 Growth inhibition assay IC50 = 0.30133 μM SANGER
SNB75 Growth inhibition assay IC50 = 0.30346 μM SANGER
CTB-1 Growth inhibition assay IC50 = 0.30637 μM SANGER
BT-20 Growth inhibition assay IC50 = 0.31197 μM SANGER
GT3TKB Growth inhibition assay IC50 = 0.31823 μM SANGER
COR-L88 Growth inhibition assay IC50 = 0.31914 μM SANGER
Calu-6 Growth inhibition assay IC50 = 0.31971 μM SANGER
Calu-3 Growth inhibition assay IC50 = 0.32095 μM SANGER
IGR-1 Growth inhibition assay IC50 = 0.3216 μM SANGER
LS-411N Growth inhibition assay IC50 = 0.32176 μM SANGER
LAN-6 Growth inhibition assay IC50 = 0.32779 μM SANGER
ONS-76 Growth inhibition assay IC50 = 0.32956 μM SANGER
MZ7-mel Growth inhibition assay IC50 = 0.33256 μM SANGER
LB647-SCLC Growth inhibition assay IC50 = 0.33608 μM SANGER
OE33 Growth inhibition assay IC50 = 0.3378 μM SANGER
NCI-H1770 Growth inhibition assay IC50 = 0.34265 μM SANGER
MS-1 Growth inhibition assay IC50 = 0.34402 μM SANGER
NCI-H650 Growth inhibition assay IC50 = 0.34407 μM SANGER
MDA-MB-468 Growth inhibition assay IC50 = 0.34531 μM SANGER
A253 Growth inhibition assay IC50 = 0.34564 μM SANGER
LOXIMVI Growth inhibition assay IC50 = 0.3525 μM SANGER
BB49-HNC Growth inhibition assay IC50 = 0.35252 μM SANGER
HT-1080 Growth inhibition assay IC50 = 0.35371 μM SANGER
NB5 Growth inhibition assay IC50 = 0.3579 μM SANGER
LK-2 Growth inhibition assay IC50 = 0.35814 μM SANGER
KS-1 Growth inhibition assay IC50 = 0.36415 μM SANGER
OE19 Growth inhibition assay IC50 = 0.36496 μM SANGER
U031 Growth inhibition assay IC50 = 0.3658 μM SANGER
HCE-T Growth inhibition assay IC50 = 0.37153 μM SANGER
NCI-H1304 Growth inhibition assay IC50 = 0.37523 μM SANGER
SKG-IIIa Growth inhibition assay IC50 = 0.37738 μM SANGER
GDM-1 Growth inhibition assay IC50 = 0.37746 μM SANGER
CPC-N Growth inhibition assay IC50 = 0.38066 μM SANGER
KYSE-140 Growth inhibition assay IC50 = 0.38134 μM SANGER
SH-4 Growth inhibition assay IC50 = 0.38726 μM SANGER
IST-SL2 Growth inhibition assay IC50 = 0.38762 μM SANGER
SCC-4 Growth inhibition assay IC50 = 0.3877 μM SANGER
OMC-1 Growth inhibition assay IC50 = 0.38955 μM SANGER
Daudi Growth inhibition assay IC50 = 0.39242 μM SANGER
JVM-2 Growth inhibition assay IC50 = 0.39734 μM SANGER
NCI-H510A Growth inhibition assay IC50 = 0.40282 μM SANGER
NCI-H1838 Growth inhibition assay IC50 = 0.40419 μM SANGER
GCIY Growth inhibition assay IC50 = 0.41099 μM SANGER
NCI-H747 Growth inhibition assay IC50 = 0.41159 μM SANGER
NCI-H1694 Growth inhibition assay IC50 = 0.41528 μM SANGER
UACC-893 Growth inhibition assay IC50 = 0.41801 μM SANGER
DMS-153 Growth inhibition assay IC50 = 0.42526 μM SANGER
GAMG Growth inhibition assay IC50 = 0.42821 μM SANGER
LB373-MEL-D Growth inhibition assay IC50 = 0.42962 μM SANGER
8505C Growth inhibition assay IC50 = 0.42983 μM SANGER
DB Growth inhibition assay IC50 = 0.42995 μM SANGER
LoVo Growth inhibition assay IC50 = 0.43068 μM SANGER
MZ2-MEL Growth inhibition assay IC50 = 0.43247 μM SANGER
L-363 Growth inhibition assay IC50 = 0.43417 μM SANGER
HSC-4 Growth inhibition assay IC50 = 0.43445 μM SANGER
NCI-N87 Growth inhibition assay IC50 = 0.43812 μM SANGER
SK-LMS-1 Growth inhibition assay IC50 = 0.43929 μM SANGER
HO-1-N-1 Growth inhibition assay IC50 = 0.44064 μM SANGER
OAW-28 Growth inhibition assay IC50 = 0.44065 μM SANGER
SBC-1 Growth inhibition assay IC50 = 0.4477 μM SANGER
LNCaP-Clone-FGC Growth inhibition assay IC50 = 0.45008 μM SANGER
MZ1-PC Growth inhibition assay IC50 = 0.45011 μM SANGER
GB-1 Growth inhibition assay IC50 = 0.45218 μM SANGER
LCLC-103H Growth inhibition assay IC50 = 0.46087 μM SANGER
YT Growth inhibition assay IC50 = 0.46333 μM SANGER
HCT-15 Growth inhibition assay IC50 = 0.46462 μM SANGER
CaR-1 Growth inhibition assay IC50 = 0.46878 μM SANGER
SK-MEL-30 Growth inhibition assay IC50 = 0.47431 μM SANGER
TCCSUP Growth inhibition assay IC50 = 0.4817 μM SANGER
C-33-A Growth inhibition assay IC50 = 0.48687 μM SANGER
OVCAR-5 Growth inhibition assay IC50 = 0.48711 μM SANGER
CAL-12T Growth inhibition assay IC50 = 0.49125 μM SANGER
PC-14 Growth inhibition assay IC50 = 0.49127 μM SANGER
ST486 Growth inhibition assay IC50 = 0.49436 μM SANGER
HLE Growth inhibition assay IC50 = 0.49832 μM SANGER
TE-9 Growth inhibition assay IC50 = 0.50049 μM SANGER
AU565 Growth inhibition assay IC50 = 0.50096 μM SANGER
LU-165 Growth inhibition assay IC50 = 0.51311 μM SANGER
EW-11 Growth inhibition assay IC50 = 0.51336 μM SANGER
FTC-133 Growth inhibition assay IC50 = 0.51722 μM SANGER
NCI-H1648 Growth inhibition assay IC50 = 0.52301 μM SANGER
AN3-CA Growth inhibition assay IC50 = 0.52328 μM SANGER
KURAMOCHI Growth inhibition assay IC50 = 0.52344 μM SANGER
T98G Growth inhibition assay IC50 = 0.52375 μM SANGER
TK10 Growth inhibition assay IC50 = 0.52832 μM SANGER
LB2518-MEL Growth inhibition assay IC50 = 0.53456 μM SANGER
CAL-33 Growth inhibition assay IC50 = 0.53653 μM SANGER
A172 Growth inhibition assay IC50 = 0.53752 μM SANGER
D-263MG Growth inhibition assay IC50 = 0.54004 μM SANGER
CAMA-1 Growth inhibition assay IC50 = 0.54059 μM SANGER
MKN1 Growth inhibition assay IC50 = 0.54081 μM SANGER
NCI-H661 Growth inhibition assay IC50 = 0.54158 μM SANGER
YKG-1 Growth inhibition assay IC50 = 0.545 μM SANGER
GOTO Growth inhibition assay IC50 = 0.55371 μM SANGER
KYSE-450 Growth inhibition assay IC50 = 0.56311 μM SANGER
UMC-11 Growth inhibition assay IC50 = 0.56701 μM SANGER
DBTRG-05MG Growth inhibition assay IC50 = 0.57026 μM SANGER
KYSE-410 Growth inhibition assay IC50 = 0.58359 μM SANGER
MOLT-16 Growth inhibition assay IC50 = 0.58519 μM SANGER
HCC2218 Growth inhibition assay IC50 = 0.58882 μM SANGER
EFO-21 Growth inhibition assay IC50 = 0.59114 μM SANGER
S-117 Growth inhibition assay IC50 = 0.59244 μM SANGER
HCC1937 Growth inhibition assay IC50 = 0.59382 μM SANGER
THP-1 Growth inhibition assay IC50 = 0.5955 μM SANGER
GAK Growth inhibition assay IC50 = 0.59624 μM SANGER
SW756 Growth inhibition assay IC50 = 0.59691 μM SANGER
KG-1 Growth inhibition assay IC50 = 0.59714 μM SANGER
D-542MG Growth inhibition assay IC50 = 0.60165 μM SANGER
HCC38 Growth inhibition assay IC50 = 0.60411 μM SANGER
SAS Growth inhibition assay IC50 = 0.61465 μM SANGER
RVH-421 Growth inhibition assay IC50 = 0.62917 μM SANGER
JiyoyeP-2003 Growth inhibition assay IC50 = 0.62954 μM SANGER
G-401 Growth inhibition assay IC50 = 0.63447 μM SANGER
SW1990 Growth inhibition assay IC50 = 0.63705 μM SANGER
KP-N-YS Growth inhibition assay IC50 = 0.64012 μM SANGER
HD-MY-Z Growth inhibition assay IC50 = 0.64025 μM SANGER
LAMA-84 Growth inhibition assay IC50 = 0.64166 μM SANGER
SW13 Growth inhibition assay IC50 = 0.64249 μM SANGER
HCC1569 Growth inhibition assay IC50 = 0.64461 μM SANGER
CP66-MEL Growth inhibition assay IC50 = 0.64495 μM SANGER
SK-HEP-1 Growth inhibition assay IC50 = 0.64566 μM SANGER
NB13 Growth inhibition assay IC50 = 0.64603 μM SANGER
NY Growth inhibition assay IC50 = 0.65739 μM SANGER
EHEB Growth inhibition assay IC50 = 0.67213 μM SANGER
MEG-01 Growth inhibition assay IC50 = 0.68336 μM SANGER
HCC70 Growth inhibition assay IC50 = 0.69433 μM SANGER
OVCAR-4 Growth inhibition assay IC50 = 0.69691 μM SANGER
NCI-H1792 Growth inhibition assay IC50 = 0.69734 μM SANGER
HEC-1 Growth inhibition assay IC50 = 0.69824 μM SANGER
NCI-H187 Growth inhibition assay IC50 = 0.70799 μM SANGER
TGBC24TKB Growth inhibition assay IC50 = 0.71 μM SANGER
HuP-T3 Growth inhibition assay IC50 = 0.71055 μM SANGER
SK-MEL-3 Growth inhibition assay IC50 = 0.71112 μM SANGER
MDA-MB-415 Growth inhibition assay IC50 = 0.72395 μM SANGER
HCC2157 Growth inhibition assay IC50 = 0.72685 μM SANGER
NCI-H2081 Growth inhibition assay IC50 = 0.74057 μM SANGER
ES6 Growth inhibition assay IC50 = 0.74562 μM SANGER
KYSE-520 Growth inhibition assay IC50 = 0.77218 μM SANGER
BxPC-3 Growth inhibition assay IC50 = 0.77478 μM SANGER
NCI-H226 Growth inhibition assay IC50 = 0.77721 μM SANGER
LB771-HNC Growth inhibition assay IC50 = 0.77974 μM SANGER
CP50-MEL-B Growth inhibition assay IC50 = 0.78003 μM SANGER
HN Growth inhibition assay IC50 = 0.78254 μM SANGER
EW-24 Growth inhibition assay IC50 = 0.78297 μM SANGER
A673 Growth inhibition assay IC50 = 0.7896 μM SANGER
COLO-684 Growth inhibition assay IC50 = 0.7993 μM SANGER
DMS-53 Growth inhibition assay IC50 = 0.80856 μM SANGER
MDA-MB-361 Growth inhibition assay IC50 = 0.80898 μM SANGER
SNU-475 Growth inhibition assay IC50 = 0.81314 μM SANGER
LB831-BLC Growth inhibition assay IC50 = 0.81608 μM SANGER
RCM-1 Growth inhibition assay IC50 = 0.84728 μM SANGER
NCI-H2347 Growth inhibition assay IC50 = 0.84997 μM SANGER
NCI-H2141 Growth inhibition assay IC50 = 0.85281 μM SANGER
Becker Growth inhibition assay IC50 = 0.86232 μM SANGER
LC-1F Growth inhibition assay IC50 = 0.86233 μM SANGER
SCC-15 Growth inhibition assay IC50 = 0.86386 μM SANGER
U-266 Growth inhibition assay IC50 = 0.86618 μM SANGER
SCC-25 Growth inhibition assay IC50 = 0.87036 μM SANGER
NCI-H1155 Growth inhibition assay IC50 = 0.87336 μM SANGER
NCI-H292 Growth inhibition assay IC50 = 0.88441 μM SANGER
NCI-H2196 Growth inhibition assay IC50 = 0.886 μM SANGER
EKVX Growth inhibition assay IC50 = 0.893 μM SANGER
TE-6 Growth inhibition assay IC50 = 0.89367 μM SANGER
NCI-H1693 Growth inhibition assay IC50 = 0.89963 μM SANGER
HuCCT1 Growth inhibition assay IC50 = 0.90351 μM SANGER
NCI-H1581 Growth inhibition assay IC50 = 0.90674 μM SANGER
KARPAS-422 Growth inhibition assay IC50 = 0.90739 μM SANGER
C8166 Growth inhibition assay IC50 = 0.93232 μM SANGER
BEN Growth inhibition assay IC50 = 0.93516 μM SANGER
SCLC-21H Growth inhibition assay IC50 = 0.96303 μM SANGER
HT-1376 Growth inhibition assay IC50 = 0.96711 μM SANGER
NCI-H1963 Growth inhibition assay IC50 = 0.97437 μM SANGER
MPP-89 Growth inhibition assay IC50 = 0.99122 μM SANGER
SW1417 Growth inhibition assay IC50 = 1.00545 μM SANGER
NCCIT Growth inhibition assay IC50 = 1.01024 μM SANGER
MMAC-SF Growth inhibition assay IC50 = 1.01163 μM SANGER
LU-65 Growth inhibition assay IC50 = 1.01247 μM SANGER
NCI-H1623 Growth inhibition assay IC50 = 1.01428 μM SANGER
HCT-116 Growth inhibition assay IC50 = 1.01502 μM SANGER
CA46 Growth inhibition assay IC50 = 1.0198 μM SANGER
RERF-LC-MS Growth inhibition assay IC50 = 1.03157 μM SANGER
DJM-1 Growth inhibition assay IC50 = 1.03304 μM SANGER
EM-2 Growth inhibition assay IC50 = 1.03374 μM SANGER
HCC1395 Growth inhibition assay IC50 = 1.05754 μM SANGER
HCC1143 Growth inhibition assay IC50 = 1.0664 μM SANGER
HH Growth inhibition assay IC50 = 1.0738 μM SANGER
MDA-MB-453 Growth inhibition assay IC50 = 1.07917 μM SANGER
COLO-320-HSR Growth inhibition assay IC50 = 1.0792 μM SANGER
KM12 Growth inhibition assay IC50 = 1.08364 μM SANGER
KNS-42 Growth inhibition assay IC50 = 1.09239 μM SANGER
HPAF-II Growth inhibition assay IC50 = 1.09715 μM SANGER
OVCAR-3 Growth inhibition assay IC50 = 1.12787 μM SANGER
EFO-27 Growth inhibition assay IC50 = 1.13122 μM SANGER
L-428 Growth inhibition assay IC50 = 1.15778 μM SANGER
LS-513 Growth inhibition assay IC50 = 1.17808 μM SANGER
NB12 Growth inhibition assay IC50 = 1.20371 μM SANGER
NCI-H23 Growth inhibition assay IC50 = 1.20661 μM SANGER
TGBC1TKB Growth inhibition assay IC50 = 1.21141 μM SANGER
LU-139 Growth inhibition assay IC50 = 1.21841 μM SANGER
Raji Growth inhibition assay IC50 = 1.22094 μM SANGER
IPC-298 Growth inhibition assay IC50 = 1.22841 μM SANGER
NCI-H838 Growth inhibition assay IC50 = 1.23291 μM SANGER
RPMI-8226 Growth inhibition assay IC50 = 1.23847 μM SANGER
LC4-1 Growth inhibition assay IC50 = 1.23959 μM SANGER
MN-60 Growth inhibition assay IC50 = 1.26332 μM SANGER
U-87-MG Growth inhibition assay IC50 = 1.27372 μM SANGER
BL-70 Growth inhibition assay IC50 = 1.27667 μM SANGER
MLMA Growth inhibition assay IC50 = 1.30978 μM SANGER
RPMI-8866 Growth inhibition assay IC50 = 1.31777 μM SANGER
M14 Growth inhibition assay IC50 = 1.3376 μM SANGER
RCC10RGB Growth inhibition assay IC50 = 1.34936 μM SANGER
SK-MEL-24 Growth inhibition assay IC50 = 1.37423 μM SANGER
SHP-77 Growth inhibition assay IC50 = 1.3783 μM SANGER
EFE-184 Growth inhibition assay IC50 = 1.38125 μM SANGER
GI-ME-N Growth inhibition assay IC50 = 1.39089 μM SANGER
SF126 Growth inhibition assay IC50 = 1.40565 μM SANGER
Saos-2 Growth inhibition assay IC50 = 1.40649 μM SANGER
KARPAS-299 Growth inhibition assay IC50 = 1.41651 μM SANGER
MC116 Growth inhibition assay IC50 = 1.41664 μM SANGER
NCI-H1563 Growth inhibition assay IC50 = 1.42784 μM SANGER
COLO-824 Growth inhibition assay IC50 = 1.44461 μM SANGER
IST-SL1 Growth inhibition assay IC50 = 1.4462 μM SANGER
HDLM-2 Growth inhibition assay IC50 = 1.4601 μM SANGER
NCI-H1573 Growth inhibition assay IC50 = 1.46085 μM SANGER
NCI-H2171 Growth inhibition assay IC50 = 1.49785 μM SANGER
NOS-1 Growth inhibition assay IC50 = 1.50227 μM SANGER
COLO-792 Growth inhibition assay IC50 = 1.50264 μM SANGER
SNU-423 Growth inhibition assay IC50 = 1.52181 μM SANGER
C32 Growth inhibition assay IC50 = 1.52834 μM SANGER
KOSC-2 Growth inhibition assay IC50 = 1.53103 μM SANGER
NCI-H64 Growth inhibition assay IC50 = 1.53444 μM SANGER
HT Growth inhibition assay IC50 = 1.53659 μM SANGER
NCI-H596 Growth inhibition assay IC50 = 1.5377 μM SANGER
NCI-H720 Growth inhibition assay IC50 = 1.54425 μM SANGER
UACC-257 Growth inhibition assay IC50 = 1.56566 μM SANGER
EVSA-T Growth inhibition assay IC50 = 1.57368 μM SANGER
KNS-81-FD Growth inhibition assay IC50 = 1.59446 μM SANGER
TE-441-T Growth inhibition assay IC50 = 1.60276 μM SANGER
U-698-M Growth inhibition assay IC50 = 1.60291 μM SANGER
COR-L105 Growth inhibition assay IC50 = 1.61317 μM SANGER
KMOE-2 Growth inhibition assay IC50 = 1.62413 μM SANGER
KY821 Growth inhibition assay IC50 = 1.65078 μM SANGER
SJRH30 Growth inhibition assay IC50 = 1.6742 μM SANGER
NCI-H69 Growth inhibition assay IC50 = 1.67882 μM SANGER
RT4 Growth inhibition assay IC50 = 1.69923 μM SANGER
LS-123 Growth inhibition assay IC50 = 1.72001 μM SANGER
BHT-101 Growth inhibition assay IC50 = 1.74029 μM SANGER
K5 Growth inhibition assay IC50 = 1.78398 μM SANGER
SK-N-AS Growth inhibition assay IC50 = 1.79073 μM SANGER
NCI-H322M Growth inhibition assay IC50 = 1.80152 μM SANGER
NCI-H1793 Growth inhibition assay IC50 = 1.81482 μM SANGER
CAL-54 Growth inhibition assay IC50 = 1.84148 μM SANGER
SK-MEL-1 Growth inhibition assay IC50 = 1.88815 μM SANGER
SiHa Growth inhibition assay IC50 = 1.8934 μM SANGER
RD Growth inhibition assay IC50 = 1.89846 μM SANGER
ChaGo-K-1 Growth inhibition assay IC50 = 1.91033 μM SANGER
SNU-C1 Growth inhibition assay IC50 = 1.914 μM SANGER
NCI-H1436 Growth inhibition assay IC50 = 1.92742 μM SANGER
HOP-92 Growth inhibition assay IC50 = 1.93658 μM SANGER
HT55 Growth inhibition assay IC50 = 1.95457 μM SANGER
K-562 Growth inhibition assay IC50 = 1.97869 μM SANGER
NCI-H2052 Growth inhibition assay IC50 = 1.98812 μM SANGER
HT-1197 Growth inhibition assay IC50 = 2.02174 μM SANGER
SW1463 Growth inhibition assay IC50 = 2.08169 μM SANGER
COLO-829 Growth inhibition assay IC50 = 2.08684 μM SANGER
DMS-114 Growth inhibition assay IC50 = 2.08692 μM SANGER
EFM-19 Growth inhibition assay IC50 = 2.08896 μM SANGER
LN-405 Growth inhibition assay IC50 = 2.15428 μM SANGER
UACC-62 Growth inhibition assay IC50 = 2.15533 μM SANGER
MDA-MB-134-VI Growth inhibition assay IC50 = 2.1586 μM SANGER
MDA-MB-157 Growth inhibition assay IC50 = 2.19254 μM SANGER
COLO-741 Growth inhibition assay IC50 = 2.19928 μM SANGER
JEG-3 Growth inhibition assay IC50 = 2.23191 μM SANGER
NB6 Growth inhibition assay IC50 = 2.23352 μM SANGER
NCI-H1395 Growth inhibition assay IC50 = 2.23483 μM SANGER
KARPAS-45 Growth inhibition assay IC50 = 2.27184 μM SANGER
HCC1954 Growth inhibition assay IC50 = 2.28119 μM SANGER
A704 Growth inhibition assay IC50 = 2.38311 μM SANGER
SK-N-DZ Growth inhibition assay IC50 = 2.38958 μM SANGER
EGI-1 Growth inhibition assay IC50 = 2.39059 μM SANGER
TALL-1 Growth inhibition assay IC50 = 2.3955 μM SANGER
PANC-08-13 Growth inhibition assay IC50 = 2.39777 μM SANGER
NCI-H28 Growth inhibition assay IC50 = 2.43524 μM SANGER
DMS-79 Growth inhibition assay IC50 = 2.47163 μM SANGER
NCI-H889 Growth inhibition assay IC50 = 2.48342 μM SANGER
Ramos-2G6-4C10 Growth inhibition assay IC50 = 2.54572 μM SANGER
BT-474 Growth inhibition assay IC50 = 2.62326 μM SANGER
JVM-3 Growth inhibition assay IC50 = 2.64752 μM SANGER
NCI-H524 Growth inhibition assay IC50 = 2.7032 μM SANGER
SK-MM-2 Growth inhibition assay IC50 = 2.71695 μM SANGER
TGW Growth inhibition assay IC50 = 2.75803 μM SANGER
Capan-2 Growth inhibition assay IC50 = 2.78528 μM SANGER
NCI-H82 Growth inhibition assay IC50 = 2.80193 μM SANGER
NCI-H716 Growth inhibition assay IC50 = 2.82042 μM SANGER
MSTO-211H Growth inhibition assay IC50 = 2.82369 μM SANGER
COLO-678 Growth inhibition assay IC50 = 2.88691 μM SANGER
AsPC-1 Growth inhibition assay IC50 = 2.89855 μM SANGER
DV-90 Growth inhibition assay IC50 = 2.92143 μM SANGER
SNU-387 Growth inhibition assay IC50 = 2.93467 μM SANGER
KLE Growth inhibition assay IC50 = 2.98224 μM SANGER
U-118-MG Growth inhibition assay IC50 = 3.14284 μM SANGER
MHH-PREB-1 Growth inhibition assay IC50 = 3.14735 μM SANGER
MDA-MB-175-VII Growth inhibition assay IC50 = 3.15819 μM SANGER
EB-3 Growth inhibition assay IC50 = 3.19768 μM SANGER
HuH-7 Growth inhibition assay IC50 = 3.22286 μM SANGER
NCI-H1522 Growth inhibition assay IC50 = 3.23546 μM SANGER
MDA-MB-231 Growth inhibition assay IC50 = 3.23964 μM SANGER
NCI-H1092 Growth inhibition assay IC50 = 3.2799 μM SANGER
KU-19-19 Growth inhibition assay IC50 = 3.35835 μM SANGER
SNU-449 Growth inhibition assay IC50 = 3.36209 μM SANGER
CAS-1 Growth inhibition assay IC50 = 3.38185 μM SANGER
KP-N-YN Growth inhibition assay IC50 = 3.41535 μM SANGER
P31-FUJ Growth inhibition assay IC50 = 3.45775 μM SANGER
RMG-I Growth inhibition assay IC50 = 3.46127 μM SANGER
SN12C Growth inhibition assay IC50 = 3.46177 μM SANGER
HCC1419 Growth inhibition assay IC50 = 3.48402 μM SANGER
TT Growth inhibition assay IC50 = 3.67775 μM SANGER
SW948 Growth inhibition assay IC50 = 3.75281 μM SANGER
SCC-9 Growth inhibition assay IC50 = 3.78753 μM SANGER
KMS-12-PE Growth inhibition assay IC50 = 3.82788 μM SANGER
GMS-10 Growth inhibition assay IC50 = 3.83807 μM SANGER
EW-18 Growth inhibition assay IC50 = 3.9388 μM SANGER
SK-MEL-2 Growth inhibition assay IC50 = 3.97464 μM SANGER
PC-3 Growth inhibition assay IC50 = 4.07159 μM SANGER
IST-MES1 Growth inhibition assay IC50 = 4.14621 μM SANGER
PLC-PRF-5 Growth inhibition assay IC50 = 4.19446 μM SANGER
YAPC Growth inhibition assay IC50 = 4.36751 μM SANGER
RXF393 Growth inhibition assay IC50 = 4.38975 μM SANGER
LP-1 Growth inhibition assay IC50 = 4.55967 μM SANGER
JAR Growth inhibition assay IC50 = 4.56384 μM SANGER
GCT Growth inhibition assay IC50 = 4.6047 μM SANGER
SW1088 Growth inhibition assay IC50 = 4.66827 μM SANGER
NCI-H345 Growth inhibition assay IC50 = 4.73193 μM SANGER
Calu-1 Growth inhibition assay IC50 = 4.8072 μM SANGER
ECC4 Growth inhibition assay IC50 = 5.07036 μM SANGER
DOK Growth inhibition assay IC50 = 5.1551 μM SANGER
RL Growth inhibition assay IC50 = 5.43657 μM SANGER
NCI-H1755 Growth inhibition assay IC50 = 5.43694 μM SANGER
HTC-C3 Growth inhibition assay IC50 = 5.78944 μM SANGER
PFSK-1 Growth inhibition assay IC50 = 5.88351 μM SANGER
CAL-120 Growth inhibition assay IC50 = 5.96351 μM SANGER
Hs-578-T Growth inhibition assay IC50 = 6.20302 μM SANGER
DG-75 Growth inhibition assay IC50 = 6.2494 μM SANGER
NCI-H2227 Growth inhibition assay IC50 = 6.32364 μM SANGER
OPM-2 Growth inhibition assay IC50 = 6.34857 μM SANGER
T47D Growth inhibition assay IC50 = 6.37191 μM SANGER
HuO-3N1 Growth inhibition assay IC50 = 6.45452 μM SANGER
D-392MG Growth inhibition assay IC50 = 6.68451 μM SANGER
NCI-SNU-16 Growth inhibition assay IC50 = 6.74309 μM SANGER
CW-2 Growth inhibition assay IC50 = 7.72758 μM SANGER
no-11 Growth inhibition assay IC50 = 7.74202 μM SANGER
MFE-280 Growth inhibition assay IC50 = 8.34873 μM SANGER
KINGS-1 Growth inhibition assay IC50 = 8.61164 μM SANGER
HCC1187 Growth inhibition assay IC50 = 8.9213 μM SANGER
NCI-H2452 Growth inhibition assay IC50 = 8.93628 μM SANGER
C2BBe1 Growth inhibition assay IC50 = 9.284 μM SANGER
Mewo Growth inhibition assay IC50 = 9.55233 μM SANGER
MFM-223 Growth inhibition assay IC50 = 10.3807 μM SANGER
NCI-H446 Growth inhibition assay IC50 = 12.4227 μM SANGER
RO82-W-1 Growth inhibition assay IC50 = 13.3274 μM SANGER
EC-GI-10 Growth inhibition assay IC50 = 14.9132 μM SANGER
UACC-812 Growth inhibition assay IC50 = 16.8306 μM SANGER
SK-MEL-28 Growth inhibition assay IC50 = 18.9731 μM SANGER
DK-MG Growth inhibition assay IC50 = 21.667 μM SANGER
NCI-H1993 Growth inhibition assay IC50 = 22.984 μM SANGER
U-2-OS Growth inhibition assay IC50 = 23.6987 μM SANGER
MKN7 Growth inhibition assay IC50 = 27.8562 μM SANGER
SK-N-FI Growth inhibition assay IC50 = 39.7075 μM SANGER
CAL-72 Growth inhibition assay IC50 = 46.7339 μM SANGER
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生物活性

製品説明 Mitomycin C (Ametycine) is an antineoplastic antibiotic by inhibiting DNA synthesis, used to treat different cancers. Mitomycin C induces apoptosis in a caspases-dependent and Fas/CD95-independent manner.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing.
Targets
DNA synthesis [1]
In Vitro
In vitro

Mitomycin C, by inducing DNA interstrand crosslinks, physically blocks DNA replication, recombination, and RNA transcription. [1] Mitomycin C potentiates TRAIL-induced apoptosis in HCT116 (p53-/-) colon cancer cells and sensitizes TRAIL-resistant colon cancer cells HT-29 to the cytokine by through JNK-independent upregulation of death receptors. [2] In different human cancer cell lines, such OVCAR-5 (ovary), HT-29 (colon), SK-N-MC (neuroblastoma), HEP-2 (liver), COLO-205 (colon), NIH-OVCAR-3 (ovary) and A-549 (lung) cells, Mitomycin C shows cytotoxic activity. [3]
細胞実験 細胞株 HCT116 cells
濃度 5 µM
反応時間 24 h
実験の流れ

Cells were pre-treated with 5 µM MMC for 24 h and then co-treated with TRAIL (25 ng/mL).
実験結果図 Methods Biomarkers 結果図 PMID
Western blot GRP78 / CHOP / Caspase-4 / Cleaved caspase-4 Beclin 1 / p62 / ATG5 p-Akt / Akt / p-S6K / S6K / p-Jun / JNK PARP / Caspase 8 / Caspase 9 / Cleaved caspase-9 / Caspase 3 / Cleaved caspase-3 28553347
In Vivo
In Vivo

As the clinical first choice in superficial bladder tumors, in a rat bladder tumor model, Mitomycin C (400 μM) significantly prevents intravesical tumor growth. [4]
動物実験 動物モデル Rat bladder tumor model
投与量 400 μM
投与経路 Intravesical treatment
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04934540 Recruiting
Bladder Cancer
Chinese University of Hong Kong
 January 1 2020 --
NCT02199327 Completed
Conjunctival Intraepithelial Neoplasia|Corneal Intraepithelial Neoplasia
Coordinación de Investigación en Salud Mexico|Instituto Mexicano del Seguro Social|University of Guadalajara
 May 2014 Phase 4

化学情報

分子量 334.37 化学式

C15H18N4O5
CAS No. 50-07-7 SDF Download Mitomycin C SDFをダウンロードする
Smiles CC1=C(C(=O)C2=C(C1=O)N3CC4C(C3(C2COC(=O)N)OC)N4)N
保管 3 years -20°C(in the dark) powder

In vitro
Batch:

DMSO : 67 mg/mL ( (200.37 mM)； 吸湿したDMSOは溶解度を減少させます。新しいDMSOをご使用ください。)

Water : Insoluble

Ethanol : Insoluble

モル濃度計算器

in vivo
Batch:

Add solvents to the product individually and in order.

投与溶液組成計算機

実験計算

モル濃度計算器

質量 濃度 体積 分子量

投与溶液組成計算機(クリア溶液)

ステップ１：実験データを入力してください。（実験操作によるロスを考慮し、動物数を1匹分多くして計算・調製することを推奨します）

mg/kg g μL 匹

ステップ２：投与溶媒の組成を入力してください。（ロット毎に適した溶解組成が異なる場合があります。詳細については弊社までお問い合わせください）

% DMSO % % Tween 80 % ddH2O
%DMSO %

計算結果：

投与溶媒濃度： mg/ml;

DMSOストック溶液調製方法： mg 試薬を μL DMSOに溶解する（濃度 mg/mL, 注：濃度が当該ロットのDMSO溶解度を超える場合はご連絡ください。 )

投与溶媒調製方法：Take μL DMSOストック溶液に μL PEG300，を加え、完全溶解後μL Tween 80，を加えて完全溶解させた後 μL ddH2O，を加え完全に溶解させます。

投与溶媒調製方法：μL DMSOストック溶液に μL Corn oil，を加え、完全溶解。

注意：１.ストック溶液に沈殿、混濁などがないことをご確認ください；
２.順番通りに溶剤を加えてください。次のステップに進む前に溶液に沈殿、混濁などがないことを確認してから加えてください。ボルテックス、ソニケーション、水浴加熱など物理的な方法で溶解を早めることは可能です。

技術サポート

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Handling Instructions

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