Carbonic Anhydrase

亜型選択性的な製品

Carbonic Anhydrase I Carbonic Anhydrase II Carbonic Anhydrase IV Carbonic Anhydrase IX Carbonic Anhydrase XII

シグナル伝達経路

Carbonic Anhydrase製品

All (15)
Carbonic Anhydrase阻害剤 (14)
Carbonic Anhydrase抗体(1)
新製品

製品コード	製品名称	製品説明	文献中Selleckの製品使用例
S2866	U-104	U-104 (MST-104, NSC 213841, SLC-0111, WBI-5111) is a potent carbonic anhydrase (CA) inhibitor for CA IX and CA XII with K_i of 45.1 nM and 4.5 nM, respectively, very low inhibition for CA I and CA II.	Nat Immunol, 2023, 24(11):1867-1878 Front Oncol, 2023, 13:1118268 J Pharmacol Sci, 2023, 10.1016/j.jphs.2023.10.003
S1438	Topiramate	Topiramate (MCN 4853, RWJ 17021) is a mutil-targeted inhibitor, including voltage-gated sodium channel and calcium channel, AMPA/kainate receptor and carbonic anhydrase, used to treat epilepsy.	Cell Rep, 2022, 40(5):111153 Anticancer Res, 2021, 41(2):687-697 Neuropharmacology, 2020, 182:108371
S4506	Acetazolamide	Acetazolamide (Diamox), a potent carbonic anhydrase (CA) inhibitor, is commonly used in clinical practice as an immediate and readily available option for acute reduction of intraocular pressure(IOP).	Cell Commun Signal, 2024, 22(1):383 Int Ophthalmol, 2024, 44(1):437 Biomed Pharmacother, 2022, 156:113982
S1375	Dorzolamide HCl	Dorzolamide (MK-507, L-671152) HCl is a water-soluble, potent inhibitor of human carbonic anhydrase II and IV with K_i of 1.9 nM and 31 nM, respectively, used as anti-glaucoma agent.	Neuro Oncol, 2021, noab156 ETD, 2020, N/A
S3178	Brinzolamide	Brinzolamide (AL-4862) is a potent carbonic anhydrase II inhibitor with IC50 of 3.19 nM.	bioRxiv, 2024, 2024.03.13.584872 Chinese Journal of Tissue Engineering Research, 2024, (28): 4461-4468. ETD, 2020, N/A
S3697	Mafenide hydrochloride	Mafenide is a sulfonamide that inhibits the enzyme carbonic anhydrase and is used as topical anti-infective, especially in burn therapy.	ETD, 2020, N/A
S9742	Indisulam	Indisulam (E7070), a sulfonamide anticancer agent, is a potent carbonic anhydrase (CA) inhibitor that inhibits cytosolic isozymes I and II, and transmembrane, tumor-associated isozyme IX. Indisulam suppresses the expression of cyclin E and phosphorylation of CDK2, both of which are essential for the G1 to S transition.	Oncogenesis, 2024, 13(1):25 Cancer Cell, 2022, S1535-6108(22)00312-9
S4725	Benzenesulfonamide	Benzenesulfonamide (Benzenesulphonamide, Benzosulfonamide, Phenyl sulfonamide, Benzene sulfonamide) is an inhibitor of carbonic anhydrases.	Br J Pharmacol, 2016, 173(6):1018-32
S2603	Tioxolone	Tioxolone(Thioxolone) is a metalloenzyme carbonic anhydrase I inhibitor with a Ki of 91 nM.
S1736	Methocarbamol	Methocarbamol (AHR 85) is a carbonic anhydrase inhibitor, used as a central muscle relaxant to treat skeletal muscle spasms.
S2177	Dichlorphenamide	Dichlorphenamide (Diclofenamide) is a sulfonamide and a carbonic anhydrase inhibitor of the meta-Disulfamoylbenzene class.
S4039	Methazolamide	Methazolamide (CL 8490) is a carbonic anhydrase inhibitor with K_i of 50 nM, 14 nM and 36 nM for hCA I, hCA II and bCA IV isoforms, respectively.
S3647	Mafenide Acetate	Mafenide Acetate is a sulfonamide that inhibits the enzyme carbonic anhydrase and is used as topical anti-infective, especially in burn therapy.
A2578	Girentuximab (Anti-CA9 / Carbonic anhydrase 9)	Girentuximab (Anti-CA9 / Carbonic anhydrase 9) is a chimeric monoclonal antibody that targets and binds to carbonic anhydrase IX (CAIX), a cell surface glycoprotein ubiquitously expressed in clear cell renal cell carcinoma (ccRCC). MW:145.5 KD.
S4998	2-Aminobenzenesulfonamide	2-Aminobenzenesulfonamide (Orthanilamide, O-Aminobenzenesulfonamide, O-Sulfanilamide, Benzenesulfonamide) is an inhibitor of carbonic anhydrase IX.
S2866	U-104	U-104 (MST-104, NSC 213841, SLC-0111, WBI-5111) is a potent carbonic anhydrase (CA) inhibitor for CA IX and CA XII with K_i of 45.1 nM and 4.5 nM, respectively, very low inhibition for CA I and CA II.	Nat Immunol, 2023, 24(11):1867-1878 Front Oncol, 2023, 13:1118268 J Pharmacol Sci, 2023, 10.1016/j.jphs.2023.10.003
S1438	Topiramate	Topiramate (MCN 4853, RWJ 17021) is a mutil-targeted inhibitor, including voltage-gated sodium channel and calcium channel, AMPA/kainate receptor and carbonic anhydrase, used to treat epilepsy.	Cell Rep, 2022, 40(5):111153 Anticancer Res, 2021, 41(2):687-697 Neuropharmacology, 2020, 182:108371
S4506	Acetazolamide	Acetazolamide (Diamox), a potent carbonic anhydrase (CA) inhibitor, is commonly used in clinical practice as an immediate and readily available option for acute reduction of intraocular pressure(IOP).	Cell Commun Signal, 2024, 22(1):383 Int Ophthalmol, 2024, 44(1):437 Biomed Pharmacother, 2022, 156:113982
S1375	Dorzolamide HCl	Dorzolamide (MK-507, L-671152) HCl is a water-soluble, potent inhibitor of human carbonic anhydrase II and IV with K_i of 1.9 nM and 31 nM, respectively, used as anti-glaucoma agent.	Neuro Oncol, 2021, noab156 ETD, 2020, N/A
S3178	Brinzolamide	Brinzolamide (AL-4862) is a potent carbonic anhydrase II inhibitor with IC50 of 3.19 nM.	bioRxiv, 2024, 2024.03.13.584872 Chinese Journal of Tissue Engineering Research, 2024, (28): 4461-4468. ETD, 2020, N/A
S3697	Mafenide hydrochloride	Mafenide is a sulfonamide that inhibits the enzyme carbonic anhydrase and is used as topical anti-infective, especially in burn therapy.	ETD, 2020, N/A
S9742	Indisulam	Indisulam (E7070), a sulfonamide anticancer agent, is a potent carbonic anhydrase (CA) inhibitor that inhibits cytosolic isozymes I and II, and transmembrane, tumor-associated isozyme IX. Indisulam suppresses the expression of cyclin E and phosphorylation of CDK2, both of which are essential for the G1 to S transition.	Oncogenesis, 2024, 13(1):25 Cancer Cell, 2022, S1535-6108(22)00312-9
S4725	Benzenesulfonamide	Benzenesulfonamide (Benzenesulphonamide, Benzosulfonamide, Phenyl sulfonamide, Benzene sulfonamide) is an inhibitor of carbonic anhydrases.	Br J Pharmacol, 2016, 173(6):1018-32
S2603	Tioxolone	Tioxolone(Thioxolone) is a metalloenzyme carbonic anhydrase I inhibitor with a Ki of 91 nM.
S1736	Methocarbamol	Methocarbamol (AHR 85) is a carbonic anhydrase inhibitor, used as a central muscle relaxant to treat skeletal muscle spasms.
S2177	Dichlorphenamide	Dichlorphenamide (Diclofenamide) is a sulfonamide and a carbonic anhydrase inhibitor of the meta-Disulfamoylbenzene class.
S4039	Methazolamide	Methazolamide (CL 8490) is a carbonic anhydrase inhibitor with K_i of 50 nM, 14 nM and 36 nM for hCA I, hCA II and bCA IV isoforms, respectively.
S3647	Mafenide Acetate	Mafenide Acetate is a sulfonamide that inhibits the enzyme carbonic anhydrase and is used as topical anti-infective, especially in burn therapy.
S4998	2-Aminobenzenesulfonamide	2-Aminobenzenesulfonamide (Orthanilamide, O-Aminobenzenesulfonamide, O-Sulfanilamide, Benzenesulfonamide) is an inhibitor of carbonic anhydrase IX.
A2578	Girentuximab (Anti-CA9 / Carbonic anhydrase 9)	Girentuximab (Anti-CA9 / Carbonic anhydrase 9) is a chimeric monoclonal antibody that targets and binds to carbonic anhydrase IX (CAIX), a cell surface glycoprotein ubiquitously expressed in clear cell renal cell carcinoma (ccRCC). MW:145.5 KD.

Carbonic Anhydrase阻害剤の選択性比較