Amino acid transporter

Amino acid transporter製品

All (6)
Amino acid transporter阻害剤 (5)
Amino acid transporter拮抗剤(1)
新製品

製品コード	製品名称	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S8818	V-9302	V-9302 is a competitive small molecule antagonist of transmembrane glutamine flux, that selectively and potently targets the amino acid transporter ASCT2 (SLC1A5) with an IC50 value of 9.6 μM for inhibition of glutamine uptake in HEK-293 cells. V-9302 blocks Sodium-neutral AA transporter 2 (SNAT2, SLC38A2) and the large neutral AA transporter 1 (LAT1, SLC7A5) as observed in 143B osteosarcoma cells, HCC1806 breast cancer cells and Xenopus laevis oocytes.Dilution of PBS may cause a clear aqueous solution to turn into a uniform suspension.	Nature, 2024, 10.1038/s41586-024-08272-5 Biochem Pharmacol, 2024, S0006-2952(24)00144-8 bioRxiv, 2024, 2024.09.17.613574
S6894	BCH	BCH (2-Aminobicyclo-(2,2,1)-heptane-2-carboxylic acid, LAT1-IN-1) is a selective and competitive inhibitor of system L amino acid transporter 1 (LAT1). BCH (LAT1-IN-1) induces apoptosis in cancer cells.	J Immunother Cancer, 2023, 11(6)e006728 J Immunother Cancer, 2023, 11(6)e006728 Cell Death Dis, 2023, 14(8):525
S8219	Bitopertin	Bitopertin (RG1678,RO-4917838) is a potent inhibitor of glycine transporter 1 (GlyT1), with Ki of 8.1 nM for human hGlyT1b and IC50 of 22-25 nM in Chinese hamster ovary cells.	Mol Ther, 2020, 6;28(5):1339-1358
S4218	Amoxapine	Amoxapine (CL 67772,Asendin) is a tricyclic dibenzoxazepine (an N-aryl piperazine) which acts similarly to several other tricyclic antidepressants, amoxapine inhibits GLYT2a transport activity with IC50 of 92 μM.
S6670	GPNA hydrochloride	GPNA hydrochloride (L-γ-glutamyl-p-nitroanilide hydrochloride) is a substrate of γ-glutamyltransferase (GGT) and an inhibitor of the glutamine transporter ASCT2 with an IC50 of ~250 μM in A549 cells. It also inhibits Na+-dependent carriers SNAT1, -2, -4, -5 and Na+-independent leucine transporters LAT1/2. It can be widely used in research on pancreatic cancer, breast cancer, glioblastoma multiforme, acute myelogenous leukemia, and non-small-cell lung cancer.	Redox Biol, 2023, 63:102732 Oncol Rep, 2023, 49(1)16 Nat Commun, 2022, 13(1):3034
S4702	Sarcosine	Sarcosine (N-methylglycine, Sarcosinic acid, Methylaminoacetic acid, Methylglycine) is a competitive inhibitor of the type I glycine transporter (GlyT1) and an N-methyl-D-aspartate receptor (NMDAR) co-agonist.
S6894	BCH	BCH (2-Aminobicyclo-(2,2,1)-heptane-2-carboxylic acid, LAT1-IN-1) is a selective and competitive inhibitor of system L amino acid transporter 1 (LAT1). BCH (LAT1-IN-1) induces apoptosis in cancer cells.	J Immunother Cancer, 2023, 11(6)e006728 J Immunother Cancer, 2023, 11(6)e006728 Cell Death Dis, 2023, 14(8):525
S8219	Bitopertin	Bitopertin (RG1678,RO-4917838) is a potent inhibitor of glycine transporter 1 (GlyT1), with Ki of 8.1 nM for human hGlyT1b and IC50 of 22-25 nM in Chinese hamster ovary cells.	Mol Ther, 2020, 6;28(5):1339-1358
S4218	Amoxapine	Amoxapine (CL 67772,Asendin) is a tricyclic dibenzoxazepine (an N-aryl piperazine) which acts similarly to several other tricyclic antidepressants, amoxapine inhibits GLYT2a transport activity with IC50 of 92 μM.
S6670	GPNA hydrochloride	GPNA hydrochloride (L-γ-glutamyl-p-nitroanilide hydrochloride) is a substrate of γ-glutamyltransferase (GGT) and an inhibitor of the glutamine transporter ASCT2 with an IC50 of ~250 μM in A549 cells. It also inhibits Na+-dependent carriers SNAT1, -2, -4, -5 and Na+-independent leucine transporters LAT1/2. It can be widely used in research on pancreatic cancer, breast cancer, glioblastoma multiforme, acute myelogenous leukemia, and non-small-cell lung cancer.	Redox Biol, 2023, 63:102732 Oncol Rep, 2023, 49(1)16 Nat Commun, 2022, 13(1):3034
S4702	Sarcosine	Sarcosine (N-methylglycine, Sarcosinic acid, Methylaminoacetic acid, Methylglycine) is a competitive inhibitor of the type I glycine transporter (GlyT1) and an N-methyl-D-aspartate receptor (NMDAR) co-agonist.
S8818	V-9302	V-9302 is a competitive small molecule antagonist of transmembrane glutamine flux, that selectively and potently targets the amino acid transporter ASCT2 (SLC1A5) with an IC50 value of 9.6 μM for inhibition of glutamine uptake in HEK-293 cells. V-9302 blocks Sodium-neutral AA transporter 2 (SNAT2, SLC38A2) and the large neutral AA transporter 1 (LAT1, SLC7A5) as observed in 143B osteosarcoma cells, HCC1806 breast cancer cells and Xenopus laevis oocytes.Dilution of PBS may cause a clear aqueous solution to turn into a uniform suspension.	Nature, 2024, 10.1038/s41586-024-08272-5 Biochem Pharmacol, 2024, S0006-2952(24)00144-8 bioRxiv, 2024, 2024.09.17.613574

Amino acid transporter阻害剤の選択性比較

Tags: Amino acid transporter inhibitors | Amino acid transporter Inhibition