RAAS

亜型選択性的な製品

ACE Renin

シグナル伝達経路

RAAS製品

All (22)
RAAS阻害剤 (21)
RAASモジュレータ(1)
新製品

製品コード	製品名称	製品説明	文献中Selleckの製品使用例
S2099	Temocapril HCl	Temocapril HCl (CS-622) is the hydrochloride of Temocapril, which is a long-acting angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension.	J Pers Med, 2022, 12(2)258 Hum Cell, 2022, 10.1007/s13577-022-00671-y Hum Cell, 2021, 34(6):1911-1918
S2051	Captopril	Captopril (SQ 14225,Capoten) is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 6 nM.	Gastroenterology, 2022, 162(4):1210-1225 Front Pharmacol, 2021, 12:765951 Drug Metab Dispos, 2020, 48(8):613-621
S1657	Enalaprilat Dihydrate	Enalaprilat (MK-422) is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 1.94 nM.	J Transl Med, 2021, 19(1):91 Biomolecules, 2021, 11(9)1370 Proteomics, 2019, 19(4):e1800288
S1941	Enalapril Maleate	Enalapril (MK-421) Maleate is an angiotensin-converting enzyme (ACE) inhibitor, used in the treatment of hypertension, diabetic nephropathy, and chronic heart failure.	BMC Pharmacol Toxicol, 2024, 25(1):25 BMC Pharmacol Toxicol, 2024, 25(1):25 Molecules, 2022, 27(4)1417
S2199	Aliskiren Hemifumarate	Aliskiren hemifumarate(CGP 60536 hemifumarate, CGP60536B hemifumarate, SPP 100 hemifumarate) is a direct renin inhibitor with IC50 of 1.5 nM.	Kidney Int, 2018, 94(4):689-700 J Physiol, 2018, 596(15):3217-3232
S7382	Phosphoramidon Disodium Salt	Phosphoramidon Disodium Salt is a metalloendopeptidase inhibitor, widely used as a biochemical tool. Phosphoramidon inhibited ECE, NEP, and ACE activities with IC50 values of 3.5 μM, 0.034 μM, and 78 μM, respectively.	Diagnostics, 2022, 12(11) Diagnostics (Basel), 2022, 12(11)2710
S5767	Aliskiren	Aliskiren(CGP 60536) is a renin inhibitor with antihypertensive activity.	Angiogenesis, 2017, 20(1):175-181 Am J Physiol Heart Circ Physiol, 2016, 311(3):H849-54
S1506	Perindopril Erbumine	Perindopril Erbumine (S9490-3) is a pro-drug and metabolized in vivo by hydrolysis of the ester group to form Perindoprilat, the biologically active metabolite, a potent ACE inhibitor with IC50 of 1.05 nM. Perindopril Erbumine is used for in vivo studies and Perindoprilat is recommened for in vitro research.	Neurotherapeutics, 2018, 15(2):500-510
S1284	Benazepril HCl	Benazepril HCl (CGS 14824A) is a novel angiotensin I converting enzyme inhibitor, used primarily in treatment of hypertension.	Mol Pharm, 2015, 12(9):3399-407
S2079	Moexipril HCl	Moexipril HCl (RS-10085) is a potent orally active nonsulfhydryl angiotensin converting enzyme (ACE) inhibitor, used for the treatment of hypertension and congestive heart failure.	J Cell Biochem, 2022, 10.1002/jcb.30213
S5938	Benazepril	Benazepril is used to treat high blood pressure (hypertension), congestive heart failure, and chronic renal failure.	Front Pharmacol, 2021, 12:740529
S9820	Angiotensin (1-7)	Angiotensin (1-7) (Ang-(1-7), Angiotensin fragment 1-7) is a bioactive component of the renin-angiotensin system that is formed endogenously from either Ang I or Ang II. Angiotensin (1-7) is a canine ACE inhibitor with an IC50 of 0.65 μM and inhibits the activity mediated by myostatin through Mas receptor.	Int J Biol Sci, 2023, 19(8):2613-2629
S1793	Ramipril	Ramipril(HOE-498) is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 5 nM.
S2076	Lisinopril dihydrate	Lisinopril dihydrate(MK-521 dihydrate) is an angiotensin-converting enzyme (ACE) inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks, and also in preventing renal and retinal complications of diabetes.
S2581	Quinapril HCl	Quinapril HCl (CI-906, PD-109452-2) is the hydrochloride salt of quinapril that is an angiotensin-converting enzyme inhibitor with a Ki of 20 μM.
S2100	Temocapril	Temocapril (CS-622,temocaprilum) is a long-acting angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension.
S2109	Imidapril HCl	Imidapril HCl(TA-6366) is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 2.6 nM, used for the treatment of hypertension.
S5728	Delapril Hydrochloride	Delapril Hydrochloride (Alindapril) is the hydrochloride salt form of delapril, which is a lipophilic, non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity.
S5712	Zofenopril calcium	Zofenopril calcium (SQ-26991) is an angiotensin-converting enzyme (ACE) inhibitor that protects the heart and helps reduce high blood pressure.
S2488	VTP-27999 TFA	VTP-27999 TFA (VTP-27999 Trifluoroacetate, VTP-27999 2,2,2-trifluoroacetate) is an orally efficacious, selecitive alkyl amine renin inhibitor with IC50 of 0.47 nM for 0.3 nM of purified recombinant human renin.
S6468	Trandolapril	Trandolapril(RU44570) is a newly developed angiotensin-converting enzyme (ACE) inhibitor that is rapidly hydrolyzed mainly in the liver to its biologically active metabolite trandolaprilat.
S2095	Fosinopril Sodium	Fosinopril Sodium (SQ28555) is the ester prodrug of an angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension and some types of chronic heart failure.
S2099	Temocapril HCl	Temocapril HCl (CS-622) is the hydrochloride of Temocapril, which is a long-acting angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension.	J Pers Med, 2022, 12(2)258 Hum Cell, 2022, 10.1007/s13577-022-00671-y Hum Cell, 2021, 34(6):1911-1918
S2051	Captopril	Captopril (SQ 14225,Capoten) is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 6 nM.	Gastroenterology, 2022, 162(4):1210-1225 Front Pharmacol, 2021, 12:765951 Drug Metab Dispos, 2020, 48(8):613-621
S1657	Enalaprilat Dihydrate	Enalaprilat (MK-422) is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 1.94 nM.	J Transl Med, 2021, 19(1):91 Biomolecules, 2021, 11(9)1370 Proteomics, 2019, 19(4):e1800288
S1941	Enalapril Maleate	Enalapril (MK-421) Maleate is an angiotensin-converting enzyme (ACE) inhibitor, used in the treatment of hypertension, diabetic nephropathy, and chronic heart failure.	BMC Pharmacol Toxicol, 2024, 25(1):25 BMC Pharmacol Toxicol, 2024, 25(1):25 Molecules, 2022, 27(4)1417
S2199	Aliskiren Hemifumarate	Aliskiren hemifumarate(CGP 60536 hemifumarate, CGP60536B hemifumarate, SPP 100 hemifumarate) is a direct renin inhibitor with IC50 of 1.5 nM.	Kidney Int, 2018, 94(4):689-700 J Physiol, 2018, 596(15):3217-3232
S7382	Phosphoramidon Disodium Salt	Phosphoramidon Disodium Salt is a metalloendopeptidase inhibitor, widely used as a biochemical tool. Phosphoramidon inhibited ECE, NEP, and ACE activities with IC50 values of 3.5 μM, 0.034 μM, and 78 μM, respectively.	Diagnostics, 2022, 12(11) Diagnostics (Basel), 2022, 12(11)2710
S5767	Aliskiren	Aliskiren(CGP 60536) is a renin inhibitor with antihypertensive activity.	Angiogenesis, 2017, 20(1):175-181 Am J Physiol Heart Circ Physiol, 2016, 311(3):H849-54
S1506	Perindopril Erbumine	Perindopril Erbumine (S9490-3) is a pro-drug and metabolized in vivo by hydrolysis of the ester group to form Perindoprilat, the biologically active metabolite, a potent ACE inhibitor with IC50 of 1.05 nM. Perindopril Erbumine is used for in vivo studies and Perindoprilat is recommened for in vitro research.	Neurotherapeutics, 2018, 15(2):500-510
S2079	Moexipril HCl	Moexipril HCl (RS-10085) is a potent orally active nonsulfhydryl angiotensin converting enzyme (ACE) inhibitor, used for the treatment of hypertension and congestive heart failure.	J Cell Biochem, 2022, 10.1002/jcb.30213
S5938	Benazepril	Benazepril is used to treat high blood pressure (hypertension), congestive heart failure, and chronic renal failure.	Front Pharmacol, 2021, 12:740529
S9820	Angiotensin (1-7)	Angiotensin (1-7) (Ang-(1-7), Angiotensin fragment 1-7) is a bioactive component of the renin-angiotensin system that is formed endogenously from either Ang I or Ang II. Angiotensin (1-7) is a canine ACE inhibitor with an IC50 of 0.65 μM and inhibits the activity mediated by myostatin through Mas receptor.	Int J Biol Sci, 2023, 19(8):2613-2629
S1793	Ramipril	Ramipril(HOE-498) is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 5 nM.
S2076	Lisinopril dihydrate	Lisinopril dihydrate(MK-521 dihydrate) is an angiotensin-converting enzyme (ACE) inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks, and also in preventing renal and retinal complications of diabetes.
S2581	Quinapril HCl	Quinapril HCl (CI-906, PD-109452-2) is the hydrochloride salt of quinapril that is an angiotensin-converting enzyme inhibitor with a Ki of 20 μM.
S2100	Temocapril	Temocapril (CS-622,temocaprilum) is a long-acting angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension.
S2109	Imidapril HCl	Imidapril HCl(TA-6366) is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 2.6 nM, used for the treatment of hypertension.
S5728	Delapril Hydrochloride	Delapril Hydrochloride (Alindapril) is the hydrochloride salt form of delapril, which is a lipophilic, non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity.
S5712	Zofenopril calcium	Zofenopril calcium (SQ-26991) is an angiotensin-converting enzyme (ACE) inhibitor that protects the heart and helps reduce high blood pressure.
S2488	VTP-27999 TFA	VTP-27999 TFA (VTP-27999 Trifluoroacetate, VTP-27999 2,2,2-trifluoroacetate) is an orally efficacious, selecitive alkyl amine renin inhibitor with IC50 of 0.47 nM for 0.3 nM of purified recombinant human renin.
S6468	Trandolapril	Trandolapril(RU44570) is a newly developed angiotensin-converting enzyme (ACE) inhibitor that is rapidly hydrolyzed mainly in the liver to its biologically active metabolite trandolaprilat.
S2095	Fosinopril Sodium	Fosinopril Sodium (SQ28555) is the ester prodrug of an angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension and some types of chronic heart failure.
S1284	Benazepril HCl	Benazepril HCl (CGS 14824A) is a novel angiotensin I converting enzyme inhibitor, used primarily in treatment of hypertension.	Mol Pharm, 2015, 12(9):3399-407

RAAS阻害剤の選択性比較