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PKM
PKM製品
- All (8)
- PKM阻害剤 (3)
- PKM活性剤(5)
- 新製品
| 製品コード | 製品名称 | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
|---|---|---|---|---|
| S8279 | Shikonin | Shikonin, a potent and specific Pyruvate kinase M2 (PKM2) inhibitor, is a major component of zicao (purple gromwell, the dried root of Lithospermum erythrorhizon), a Chinese herbal medicine with various biological activities. It is also an inhibitor of TMEM16A chloride channel activity using cell-based fluorescent-quenching assay. Shikonin exerts an anti-inflammatory effect by inhibiting tumor necrosis factor-α (TNF-α) and prevents activation of nuclear factor-κB (NF-κB) pathway via proteasome inhibition. | ||
| S8616 | PKM2 inhibitor(compound 3k) | PKM2 inhibitor(Compound 3K, PKM2-IN-1) displays PKM2 inhibitory activity with the IC50 value of 2.95 μM. The IC50 value for PKM1 is 4-5-fold higher than that for PKM2. | ||
| S7928 | DASA-58 | DASA-58 is a specific and potent Pyruvate kinase M2 (PKM2) activator. |
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| S7302 | TEPP-46 (ML265) | TEPP-46 (ML265, CID-44246499, NCGC00186528) is a potent activator of PKM2 in both biochemical (AC50 = 92 nM) and cell-based assays with high selectivity over PKM1, PKR and PKL. | ||
| S6508 | Mitapivat | Mitapivat (AG-348) is an activator of a pyruvate kinase PKM2, an enzyme involved in glycolysis. | ||
| E1328 | TP-1454 | TP-1454 is an activator of PKM2 with AC50 of 10 Nm in biochemical assays.TP-1454 modulates tumor-immune responses by destabilizing T-regulatory cells. | ||
| E2829 | Alkannin | Alkannin is a potent and specific inhibitor of tumor-specific pyruvate kinase-M2 (PKM2), without inhibiting PKM1 and pyruvate kinase-L (PKL). | ||
| S5545 | DL-Serine | Serine is a non-essential amino acid and a natural ligand and allosteric activator of pyruvate kinase M2. | ||
| S8279 | Shikonin | Shikonin, a potent and specific Pyruvate kinase M2 (PKM2) inhibitor, is a major component of zicao (purple gromwell, the dried root of Lithospermum erythrorhizon), a Chinese herbal medicine with various biological activities. It is also an inhibitor of TMEM16A chloride channel activity using cell-based fluorescent-quenching assay. Shikonin exerts an anti-inflammatory effect by inhibiting tumor necrosis factor-α (TNF-α) and prevents activation of nuclear factor-κB (NF-κB) pathway via proteasome inhibition. | ||
| S8616 | PKM2 inhibitor(compound 3k) | PKM2 inhibitor(Compound 3K, PKM2-IN-1) displays PKM2 inhibitory activity with the IC50 value of 2.95 μM. The IC50 value for PKM1 is 4-5-fold higher than that for PKM2. | ||
| E2829 | Alkannin | Alkannin is a potent and specific inhibitor of tumor-specific pyruvate kinase-M2 (PKM2), without inhibiting PKM1 and pyruvate kinase-L (PKL). | ||
| S7928 | DASA-58 | DASA-58 is a specific and potent Pyruvate kinase M2 (PKM2) activator. |
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| S7302 | TEPP-46 (ML265) | TEPP-46 (ML265, CID-44246499, NCGC00186528) is a potent activator of PKM2 in both biochemical (AC50 = 92 nM) and cell-based assays with high selectivity over PKM1, PKR and PKL. | ||
| S6508 | Mitapivat | Mitapivat (AG-348) is an activator of a pyruvate kinase PKM2, an enzyme involved in glycolysis. | ||
| E1328 | TP-1454 | TP-1454 is an activator of PKM2 with AC50 of 10 Nm in biochemical assays.TP-1454 modulates tumor-immune responses by destabilizing T-regulatory cells. | ||
| S5545 | DL-Serine | Serine is a non-essential amino acid and a natural ligand and allosteric activator of pyruvate kinase M2. |
PKM阻害剤の選択性比較
Tags: PKM activator | PKM inhibitor | PKM modulator |PKM activity
納期 国内在庫品：受注日の翌日（15時までの受注分） ＊北海道、九州、沖縄への配送は受注日より２日以上 を要する場合あり 海外在庫品：受注後１〜２週間