P-gp

P-gp製品

• All (19)
• P-gp阻害剤 (13)
• P-gp作動薬(1)
• P-gpモジュレータ(4)
• 新製品

製品コード	製品名称	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S8028	Tariquidar	Tariquidar is a potent and selective noncompetitive inhibitor of P-glycoprotein with Kd of 5.1 nM in CHrB30 cell line, reverses drug resistance in MDR cell Lines. Phase 3.	Drug Resist Updat, 2024, 73:101066 Int J Mol Sci, 2024, 25(6)3107 Exp Hematol, 2024, S0301-472X(24)00516-2
S1481	Zosuquidar 3HCl	Zosuquidar 3HCl is a potent modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM in a cell-free assay. Phase 3.	Hepatol Commun, 2024, 8(5)e0437 Adv Healthc Mater, 2022, e2201984 Mol Cancer Ther, 2022, 21 (7): 1227–1235.
S4202	Verapamil HCl	Verapamil HCl is an L-type calcium channel blocker that is a class IV anti-arrhythmia agent. Verapamil inhibits both permeability-glycoprotein (P-gp) and CYP3A4.	J Immunother Cancer, 2024, 12(11)e009805 NPJ Precis Oncol, 2024, 8(1):94 Int J Mol Sci, 2024, 25(18)10162
S7772	Elacridar (GF120918)	Elacridar (GF120918, GW120918, GG918, GW0918) is a potent P-gp (MDR-1) and BCRP inhibitor.	Cell Death Dis, 2024, 15(8):558 Oncogene, 2024, 43(26):2038-2050 Pharmaceutics, 2024, 16(10)1290
S7124	SC144	SC144 is the first-in-class orally active small-molecule gp130 inhibitor that induces gp130 phosphorylation (S782) and deglycosylation, abrogates Stat3 phosphorylation and nuclear translocation, and further inhibits the expression of downstream target genes.	Nat Med, 2024, 10.1038/s41591-024-02953-4 Nat Commun, 2024, 15(1):1041 Cell Stem Cell, 2023, 30(10):1382-1391.e5
S4662	Atazanavir	Atazanavir (Latazanavir, Zrivada, Reyataz, BMS-232632) is an azapeptide and HIV-protease inhibitor that is used in the treatment of HIV infections and AIDS in combination with other anti-HIV agents. Atazanavir is a substrate and inhibitor of cytochrome P450 isozyme 3A (CYP3A4) and an inhibitor and inducer of P-glycoprotein.	Int J Mol Sci, 2022, 23(23)15380 Chemistry, 2022, e202202798. Cells, 2021, 10(12)3458
S9145	Solamargine	Solamargine, a bioactive steroidal alkaloid isolated from Solanum aculeastrum, induces potent, non-selective cytotoxicity and P-gp inhibition.	Sci Rep, 2016, 6:36721
S3235	Sinapine	Sinapine is an alkaloid isolated from seeds of the cruciferous species with antioxidant, antitumor and radio-protective activities. Sinapine inhibits the proliferation of Caco-2 cells via downregulation of P-glycoprotein.	Gene, 2022, 827:146460
S0921	Wilforine	Wilforine (WR), a sesquiterpene pyridine alkaloid found in T. wilfordii plants, significantly inhibits the efflux activity of P-glycoprotein (P-gp).
S3431	Encequidar (HM30181)	Encequidar (HM30181, HM30181A) is a potent and selective inhibitor of the adenosine triphosphate-binding cassette transporter P-glycoprotein (P-gp).
E1781New	Biricodar	Biricodar(VX-710) is a modulator of P-glycoprotein and MRP-1 with minimal in vivo toxicity. It enhances the effectiveness of various antibiotics against numerous gram-positive pathogens and exhibits potent chemosensitizing properties in cells resistant to multiple drugs.
S3600	Schisandrin B	Schisandrin B is the most abundant dibenzocyclooctadiene lignan present in the traditional Chinese medicinal herb Schisandra chinensis (Turcz.) Baill. It is a kind of ATR and P-gp inhibitor with high safety.	Drug Des Devel Ther, 2024, 18:4241-4256 Viruses, 2022, 14(2)353 Pharmacol Res, 2021, 166:105459
S4746	(20S)-Protopanaxadiol	20(S)-Protopanaxadiol (PPD, 20-Epiprotopanaxadiol), the main intestinal metabolite of ginsenosides, is one of the active ingredients in ginseng. 20(S)-Protopanaxadiol inhibits P-glycoprotein in multidrug resistant cancer cells.
E4980New	Verapamil	Verapamil(Iproveratril,Dilacoran), is a phenylalkylamine derivative which is an antagonist of calcium influx and also an inhibitor P-gp and CYP3A4. It exhibits potency in treatment for angina, cardiac arrhythmias, cardiomyopathies and hypertension.	Cell Death Dis, 2024, 15(11):855
E0080	UCLA GP130 2	UCLA GP130 2 (GP130 receptor agonist-1) is a potent, brain-penetrant and orally active Glycoprotein 130 (Gp130) receptor agonist, being a humanin mimetic binding to the GP130 D4-D5 domain and reducing NMDA-induced toxicity.
S9201	Levistilide A	Levistilide A (Diligustilide), a natural compound isolated from the traditional Chinese herb Ligusticum chuanxiong Hort, is a potential P-gp modulator and used for treating cancer.
S9563	Evodine	Evodine, a natural product extracted from Evodiae fructus (EF), is a biomarker for quality assessment of EF in the Chinese Pharmacopoeia. Evodine is a potent P-gp inhibitor.
E1742New	Reversan	Reversan (CBLC4H10) is a selective and nontoxic inhibitor of multidrug resistance-associated protein 1 (MRP1) and P-glycoprotein (P-gp), with the potential to treat neuroblastoma and other MRP1-overexpressing drug-refractory tumors.
E0080	UCLA GP130 2	UCLA GP130 2 (GP130 receptor agonist-1) is a potent, brain-penetrant and orally active Glycoprotein 130 (Gp130) receptor agonist, being a humanin mimetic binding to the GP130 D4-D5 domain and reducing NMDA-induced toxicity.
S8028	Tariquidar	Tariquidar is a potent and selective noncompetitive inhibitor of P-glycoprotein with Kd of 5.1 nM in CHrB30 cell line, reverses drug resistance in MDR cell Lines. Phase 3.	Drug Resist Updat, 2024, 73:101066 Int J Mol Sci, 2024, 25(6)3107 Exp Hematol, 2024, S0301-472X(24)00516-2
S4202	Verapamil HCl	Verapamil HCl is an L-type calcium channel blocker that is a class IV anti-arrhythmia agent. Verapamil inhibits both permeability-glycoprotein (P-gp) and CYP3A4.	J Immunother Cancer, 2024, 12(11)e009805 NPJ Precis Oncol, 2024, 8(1):94 Int J Mol Sci, 2024, 25(18)10162
S7772	Elacridar (GF120918)	Elacridar (GF120918, GW120918, GG918, GW0918) is a potent P-gp (MDR-1) and BCRP inhibitor.	Cell Death Dis, 2024, 15(8):558 Oncogene, 2024, 43(26):2038-2050 Pharmaceutics, 2024, 16(10)1290
S7124	SC144	SC144 is the first-in-class orally active small-molecule gp130 inhibitor that induces gp130 phosphorylation (S782) and deglycosylation, abrogates Stat3 phosphorylation and nuclear translocation, and further inhibits the expression of downstream target genes.	Nat Med, 2024, 10.1038/s41591-024-02953-4 Nat Commun, 2024, 15(1):1041 Cell Stem Cell, 2023, 30(10):1382-1391.e5
S9145	Solamargine	Solamargine, a bioactive steroidal alkaloid isolated from Solanum aculeastrum, induces potent, non-selective cytotoxicity and P-gp inhibition.	Sci Rep, 2016, 6:36721
S3235	Sinapine	Sinapine is an alkaloid isolated from seeds of the cruciferous species with antioxidant, antitumor and radio-protective activities. Sinapine inhibits the proliferation of Caco-2 cells via downregulation of P-glycoprotein.	Gene, 2022, 827:146460
S0921	Wilforine	Wilforine (WR), a sesquiterpene pyridine alkaloid found in T. wilfordii plants, significantly inhibits the efflux activity of P-glycoprotein (P-gp).
S3431	Encequidar (HM30181)	Encequidar (HM30181, HM30181A) is a potent and selective inhibitor of the adenosine triphosphate-binding cassette transporter P-glycoprotein (P-gp).
S3600	Schisandrin B	Schisandrin B is the most abundant dibenzocyclooctadiene lignan present in the traditional Chinese medicinal herb Schisandra chinensis (Turcz.) Baill. It is a kind of ATR and P-gp inhibitor with high safety.	Drug Des Devel Ther, 2024, 18:4241-4256 Viruses, 2022, 14(2)353 Pharmacol Res, 2021, 166:105459
S4746	(20S)-Protopanaxadiol	20(S)-Protopanaxadiol (PPD, 20-Epiprotopanaxadiol), the main intestinal metabolite of ginsenosides, is one of the active ingredients in ginseng. 20(S)-Protopanaxadiol inhibits P-glycoprotein in multidrug resistant cancer cells.
E4980New	Verapamil	Verapamil(Iproveratril,Dilacoran), is a phenylalkylamine derivative which is an antagonist of calcium influx and also an inhibitor P-gp and CYP3A4. It exhibits potency in treatment for angina, cardiac arrhythmias, cardiomyopathies and hypertension.	Cell Death Dis, 2024, 15(11):855
S9563	Evodine	Evodine, a natural product extracted from Evodiae fructus (EF), is a biomarker for quality assessment of EF in the Chinese Pharmacopoeia. Evodine is a potent P-gp inhibitor.
E1742New	Reversan	Reversan (CBLC4H10) is a selective and nontoxic inhibitor of multidrug resistance-associated protein 1 (MRP1) and P-glycoprotein (P-gp), with the potential to treat neuroblastoma and other MRP1-overexpressing drug-refractory tumors.
E0080	UCLA GP130 2	UCLA GP130 2 (GP130 receptor agonist-1) is a potent, brain-penetrant and orally active Glycoprotein 130 (Gp130) receptor agonist, being a humanin mimetic binding to the GP130 D4-D5 domain and reducing NMDA-induced toxicity.
S1481	Zosuquidar 3HCl	Zosuquidar 3HCl is a potent modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM in a cell-free assay. Phase 3.	Hepatol Commun, 2024, 8(5)e0437 Adv Healthc Mater, 2022, e2201984 Mol Cancer Ther, 2022, 21 (7): 1227–1235.
S4662	Atazanavir	Atazanavir (Latazanavir, Zrivada, Reyataz, BMS-232632) is an azapeptide and HIV-protease inhibitor that is used in the treatment of HIV infections and AIDS in combination with other anti-HIV agents. Atazanavir is a substrate and inhibitor of cytochrome P450 isozyme 3A (CYP3A4) and an inhibitor and inducer of P-glycoprotein.	Int J Mol Sci, 2022, 23(23)15380 Chemistry, 2022, e202202798. Cells, 2021, 10(12)3458
E1781New	Biricodar	Biricodar(VX-710) is a modulator of P-glycoprotein and MRP-1 with minimal in vivo toxicity. It enhances the effectiveness of various antibiotics against numerous gram-positive pathogens and exhibits potent chemosensitizing properties in cells resistant to multiple drugs.
S9201	Levistilide A	Levistilide A (Diligustilide), a natural compound isolated from the traditional Chinese herb Ligusticum chuanxiong Hort, is a potential P-gp modulator and used for treating cancer.
E1781New	Biricodar	Biricodar(VX-710) is a modulator of P-glycoprotein and MRP-1 with minimal in vivo toxicity. It enhances the effectiveness of various antibiotics against numerous gram-positive pathogens and exhibits potent chemosensitizing properties in cells resistant to multiple drugs.
E4980New	Verapamil	Verapamil(Iproveratril,Dilacoran), is a phenylalkylamine derivative which is an antagonist of calcium influx and also an inhibitor P-gp and CYP3A4. It exhibits potency in treatment for angina, cardiac arrhythmias, cardiomyopathies and hypertension.	Cell Death Dis, 2024, 15(11):855
E1742New	Reversan	Reversan (CBLC4H10) is a selective and nontoxic inhibitor of multidrug resistance-associated protein 1 (MRP1) and P-glycoprotein (P-gp), with the potential to treat neuroblastoma and other MRP1-overexpressing drug-refractory tumors.

P-gpシグナル伝達経路