P-gp

P-gp製品

• All (19)
• P-gp阻害剤 (13)
• P-gp作動薬(1)
• P-gpモジュレータ(4)
• 新製品

製品コード	製品名称	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S8028	Tariquidar	Tariquidar is a potent and selective noncompetitive inhibitor of P-glycoprotein with Kd of 5.1 nM in CHrB30 cell line, reverses drug resistance in MDR cell Lines. Phase 3.	Biomol Ther (Seoul), 2025, 33(1):170-181 Drug Resist Updat, 2024, 73:101066 Front Pharmacol, 2024, 15:1477318
S1481	Zosuquidar 3HCl	Zosuquidar 3HCl is a potent modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM in a cell-free assay. Phase 3.	Hepatol Commun, 2024, 8(5)e0437 Adv Healthc Mater, 2022, e2201984 Mol Cancer Ther, 2022, 21 (7): 1227–1235.
S4202	Verapamil HCl	Verapamil HCl is an L-type calcium channel blocker that is a class IV anti-arrhythmia agent. Verapamil inhibits both permeability-glycoprotein (P-gp) and CYP3A4.Verapamil (CP-16533-1) HCl can be used to induce animal models of Heart Failure.	J Immunother Cancer, 2024, 12(11)e009805 NPJ Precis Oncol, 2024, 8(1):94 Int J Mol Sci, 2024, 25(18)10162
S7772	Elacridar (GF120918)	Elacridar (GF120918, GW120918, GG918, GW0918) is a potent P-gp (MDR-1) and BCRP inhibitor.	Int J Mol Sci, 2025, 26(3)1124 Cell Death Dis, 2024, 15(8):558 Oncogene, 2024, 43(26):2038-2050
S7124	SC144	SC144 is the first-in-class orally active small-molecule gp130 inhibitor that induces gp130 phosphorylation (S782) and deglycosylation, abrogates Stat3 phosphorylation and nuclear translocation, and further inhibits the expression of downstream target genes.	bioRxiv, 2025, 2025.01.20.633954 Nat Med, 2024, 30(6):1696-1710 Nat Med, 2024, 10.1038/s41591-024-02953-4
S4662	Atazanavir	Atazanavir (Latazanavir, Zrivada, Reyataz, BMS-232632) is an azapeptide and HIV-protease inhibitor that is used in the treatment of HIV infections and AIDS in combination with other anti-HIV agents. Atazanavir is a substrate and inhibitor of cytochrome P450 isozyme 3A (CYP3A4) and an inhibitor and inducer of P-glycoprotein.	Int J Mol Sci, 2022, 23(23)15380 Chemistry, 2022, e202202798. Cells, 2021, 10(12)3458
S9145	Solamargine	Solamargine, a bioactive steroidal alkaloid isolated from Solanum aculeastrum, induces potent, non-selective cytotoxicity and P-gp inhibition.	Sci Rep, 2016, 6:36721
S3235	Sinapine	Sinapine is an alkaloid isolated from seeds of the cruciferous species with antioxidant, antitumor and radio-protective activities. Sinapine inhibits the proliferation of Caco-2 cells via downregulation of P-glycoprotein.	Gene, 2022, 827:146460
S0921	Wilforine	Wilforine (WR), a sesquiterpene pyridine alkaloid found in T. wilfordii plants, significantly inhibits the efflux activity of P-glycoprotein (P-gp).
S3431	Encequidar (HM30181)	Encequidar (HM30181, HM30181A) is a potent and selective inhibitor of the adenosine triphosphate-binding cassette transporter P-glycoprotein (P-gp).
E1781	Biricodar	Biricodar(VX-710) is a modulator of P-glycoprotein and MRP-1 with minimal in vivo toxicity. It enhances the effectiveness of various antibiotics against numerous gram-positive pathogens and exhibits potent chemosensitizing properties in cells resistant to multiple drugs.
S3600	Schisandrin B	Schisandrin B is the most abundant dibenzocyclooctadiene lignan present in the traditional Chinese medicinal herb Schisandra chinensis (Turcz.) Baill. It is a kind of ATR and P-gp inhibitor with high safety.	Drug Des Devel Ther, 2024, 18:4241-4256 Viruses, 2022, 14(2)353 Pharmacol Res, 2021, 166:105459
S4746	(20S)-Protopanaxadiol	20(S)-Protopanaxadiol (PPD, 20-Epiprotopanaxadiol), the main intestinal metabolite of ginsenosides, is one of the active ingredients in ginseng. 20(S)-Protopanaxadiol inhibits P-glycoprotein in multidrug resistant cancer cells.
E4980New	Verapamil	Verapamil(Iproveratril,Dilacoran), is a phenylalkylamine derivative which is an antagonist of calcium influx and also an inhibitor P-gp and CYP3A4. It exhibits potency in treatment for angina, cardiac arrhythmias, cardiomyopathies and hypertension.	J Am Heart Assoc, 2025, 14(1):e037400 Pharmaceuticals (Basel), 2025, 18(2)181 Cell Death Dis, 2024, 15(11):855
E0080	UCLA GP130 2	UCLA GP130 2 (GP130 receptor agonist-1) is a potent, brain-penetrant and orally active Glycoprotein 130 (Gp130) receptor agonist, being a humanin mimetic binding to the GP130 D4-D5 domain and reducing NMDA-induced toxicity.
S9201	Levistilide A	Levistilide A (Diligustilide), a natural compound isolated from the traditional Chinese herb Ligusticum chuanxiong Hort, is a potential P-gp modulator and used for treating cancer.
S9563	Evodine	Evodine, a natural product extracted from Evodiae fructus (EF), is a biomarker for quality assessment of EF in the Chinese Pharmacopoeia. Evodine is a potent P-gp inhibitor.
E1742	Reversan	Reversan (CBLC4H10) is a selective and nontoxic inhibitor of multidrug resistance-associated protein 1 (MRP1) and P-glycoprotein (P-gp), with the potential to treat neuroblastoma and other MRP1-overexpressing drug-refractory tumors.
E0080	UCLA GP130 2	UCLA GP130 2 (GP130 receptor agonist-1) is a potent, brain-penetrant and orally active Glycoprotein 130 (Gp130) receptor agonist, being a humanin mimetic binding to the GP130 D4-D5 domain and reducing NMDA-induced toxicity.
S8028	Tariquidar	Tariquidar is a potent and selective noncompetitive inhibitor of P-glycoprotein with Kd of 5.1 nM in CHrB30 cell line, reverses drug resistance in MDR cell Lines. Phase 3.	Biomol Ther (Seoul), 2025, 33(1):170-181 Drug Resist Updat, 2024, 73:101066 Front Pharmacol, 2024, 15:1477318
S4202	Verapamil HCl	Verapamil HCl is an L-type calcium channel blocker that is a class IV anti-arrhythmia agent. Verapamil inhibits both permeability-glycoprotein (P-gp) and CYP3A4.Verapamil (CP-16533-1) HCl can be used to induce animal models of Heart Failure.	J Immunother Cancer, 2024, 12(11)e009805 NPJ Precis Oncol, 2024, 8(1):94 Int J Mol Sci, 2024, 25(18)10162
S7772	Elacridar (GF120918)	Elacridar (GF120918, GW120918, GG918, GW0918) is a potent P-gp (MDR-1) and BCRP inhibitor.	Int J Mol Sci, 2025, 26(3)1124 Cell Death Dis, 2024, 15(8):558 Oncogene, 2024, 43(26):2038-2050
S7124	SC144	SC144 is the first-in-class orally active small-molecule gp130 inhibitor that induces gp130 phosphorylation (S782) and deglycosylation, abrogates Stat3 phosphorylation and nuclear translocation, and further inhibits the expression of downstream target genes.	bioRxiv, 2025, 2025.01.20.633954 Nat Med, 2024, 30(6):1696-1710 Nat Med, 2024, 10.1038/s41591-024-02953-4
S9145	Solamargine	Solamargine, a bioactive steroidal alkaloid isolated from Solanum aculeastrum, induces potent, non-selective cytotoxicity and P-gp inhibition.	Sci Rep, 2016, 6:36721
S3235	Sinapine	Sinapine is an alkaloid isolated from seeds of the cruciferous species with antioxidant, antitumor and radio-protective activities. Sinapine inhibits the proliferation of Caco-2 cells via downregulation of P-glycoprotein.	Gene, 2022, 827:146460
S0921	Wilforine	Wilforine (WR), a sesquiterpene pyridine alkaloid found in T. wilfordii plants, significantly inhibits the efflux activity of P-glycoprotein (P-gp).
S3431	Encequidar (HM30181)	Encequidar (HM30181, HM30181A) is a potent and selective inhibitor of the adenosine triphosphate-binding cassette transporter P-glycoprotein (P-gp).
S3600	Schisandrin B	Schisandrin B is the most abundant dibenzocyclooctadiene lignan present in the traditional Chinese medicinal herb Schisandra chinensis (Turcz.) Baill. It is a kind of ATR and P-gp inhibitor with high safety.	Drug Des Devel Ther, 2024, 18:4241-4256 Viruses, 2022, 14(2)353 Pharmacol Res, 2021, 166:105459
S4746	(20S)-Protopanaxadiol	20(S)-Protopanaxadiol (PPD, 20-Epiprotopanaxadiol), the main intestinal metabolite of ginsenosides, is one of the active ingredients in ginseng. 20(S)-Protopanaxadiol inhibits P-glycoprotein in multidrug resistant cancer cells.
E4980New	Verapamil	Verapamil(Iproveratril,Dilacoran), is a phenylalkylamine derivative which is an antagonist of calcium influx and also an inhibitor P-gp and CYP3A4. It exhibits potency in treatment for angina, cardiac arrhythmias, cardiomyopathies and hypertension.	J Am Heart Assoc, 2025, 14(1):e037400 Pharmaceuticals (Basel), 2025, 18(2)181 Cell Death Dis, 2024, 15(11):855
S9563	Evodine	Evodine, a natural product extracted from Evodiae fructus (EF), is a biomarker for quality assessment of EF in the Chinese Pharmacopoeia. Evodine is a potent P-gp inhibitor.
E1742	Reversan	Reversan (CBLC4H10) is a selective and nontoxic inhibitor of multidrug resistance-associated protein 1 (MRP1) and P-glycoprotein (P-gp), with the potential to treat neuroblastoma and other MRP1-overexpressing drug-refractory tumors.
E0080	UCLA GP130 2	UCLA GP130 2 (GP130 receptor agonist-1) is a potent, brain-penetrant and orally active Glycoprotein 130 (Gp130) receptor agonist, being a humanin mimetic binding to the GP130 D4-D5 domain and reducing NMDA-induced toxicity.
S1481	Zosuquidar 3HCl	Zosuquidar 3HCl is a potent modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM in a cell-free assay. Phase 3.	Hepatol Commun, 2024, 8(5)e0437 Adv Healthc Mater, 2022, e2201984 Mol Cancer Ther, 2022, 21 (7): 1227–1235.
S4662	Atazanavir	Atazanavir (Latazanavir, Zrivada, Reyataz, BMS-232632) is an azapeptide and HIV-protease inhibitor that is used in the treatment of HIV infections and AIDS in combination with other anti-HIV agents. Atazanavir is a substrate and inhibitor of cytochrome P450 isozyme 3A (CYP3A4) and an inhibitor and inducer of P-glycoprotein.	Int J Mol Sci, 2022, 23(23)15380 Chemistry, 2022, e202202798. Cells, 2021, 10(12)3458
E1781	Biricodar	Biricodar(VX-710) is a modulator of P-glycoprotein and MRP-1 with minimal in vivo toxicity. It enhances the effectiveness of various antibiotics against numerous gram-positive pathogens and exhibits potent chemosensitizing properties in cells resistant to multiple drugs.
S9201	Levistilide A	Levistilide A (Diligustilide), a natural compound isolated from the traditional Chinese herb Ligusticum chuanxiong Hort, is a potential P-gp modulator and used for treating cancer.
E4980New	Verapamil	Verapamil(Iproveratril,Dilacoran), is a phenylalkylamine derivative which is an antagonist of calcium influx and also an inhibitor P-gp and CYP3A4. It exhibits potency in treatment for angina, cardiac arrhythmias, cardiomyopathies and hypertension.	J Am Heart Assoc, 2025, 14(1):e037400 Pharmaceuticals (Basel), 2025, 18(2)181 Cell Death Dis, 2024, 15(11):855

P-gpシグナル伝達経路