Wee1

Wee1製品

All (5)
Wee1阻害剤 (5)
新製品

製品コード	製品名称	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S1525	Adavosertib (MK-1775)	アダボセルチブ (Adavosertib (MK-1775、AZD1775)) は、無細胞アッセイで IC50 が 5.2 nM の強力かつ選択的な Wee1 阻害剤です。G2 DNA 損傷チェックポイントを阻害します。臨床フェーズ2。	Science, 2024, 384(6700):eadk0775 Nat Biomed Eng, 2024, 10.1038/s41551-024-01273-9 Nat Commun, 2024, 15(1):2089
S8148	PD0166285	PD0166285 is a potent Wee1 and Chk1 inhibitor with activity at nanomolar concentrations (IC50=24 nM for Wee1 and 72 nM for Myt1). PD0166285 is also a novel G2 checkpoint abrogator. PD0166285 induces apoptosis.	Nat Commun, 2024, 15(1):2089 medRxiv, 2024, 2023.05.17.23290140 Nat Commun, 2023, 14(1):6088
S9778	Debio 0123	WEE1-IN-5 (Debio 0123) is a potent Wee1 inhibitor that inhibits phospho-CDC2 and abrogates the G2 check point.	medRxiv, 2024, 2023.05.17.23290140
E1000	Azenosertib (Zn-C3)	Azenosertib (Zn-C3) is an oral active, highly effective and selective Wee1 inhibitor with IC50 of 3.9 nM, which can be used in cancer research.	medRxiv, 2024, 2023.05.17.23290140
E4737^New	Potrasertib	Potrasertib (IMP7068, WEE1-IN-10) is a potent and selective inhibitor of WEE1 Kinase. It displays antitumor activity and is well-tolerated in patients with advanced solid tumors.
S1525	Adavosertib (MK-1775)	アダボセルチブ (Adavosertib (MK-1775、AZD1775)) は、無細胞アッセイで IC50 が 5.2 nM の強力かつ選択的な Wee1 阻害剤です。G2 DNA 損傷チェックポイントを阻害します。臨床フェーズ2。	Science, 2024, 384(6700):eadk0775 Nat Biomed Eng, 2024, 10.1038/s41551-024-01273-9 Nat Commun, 2024, 15(1):2089
S8148	PD0166285	PD0166285 is a potent Wee1 and Chk1 inhibitor with activity at nanomolar concentrations (IC50=24 nM for Wee1 and 72 nM for Myt1). PD0166285 is also a novel G2 checkpoint abrogator. PD0166285 induces apoptosis.	Nat Commun, 2024, 15(1):2089 medRxiv, 2024, 2023.05.17.23290140 Nat Commun, 2023, 14(1):6088
S9778	Debio 0123	WEE1-IN-5 (Debio 0123) is a potent Wee1 inhibitor that inhibits phospho-CDC2 and abrogates the G2 check point.	medRxiv, 2024, 2023.05.17.23290140
E1000	Azenosertib (Zn-C3)	Azenosertib (Zn-C3) is an oral active, highly effective and selective Wee1 inhibitor with IC50 of 3.9 nM, which can be used in cancer research.	medRxiv, 2024, 2023.05.17.23290140
E4737^New	Potrasertib	Potrasertib (IMP7068, WEE1-IN-10) is a potent and selective inhibitor of WEE1 Kinase. It displays antitumor activity and is well-tolerated in patients with advanced solid tumors.
E4737^New	Potrasertib	Potrasertib (IMP7068, WEE1-IN-10) is a potent and selective inhibitor of WEE1 Kinase. It displays antitumor activity and is well-tolerated in patients with advanced solid tumors.

Wee1阻害剤の選択性比較

Wee1シグナル伝達経路

Wee1シグナル伝達経路

Tags: Wee1 inhibitor|Wee1 agonist|Wee1 activator|Wee1 inducer|Wee1 antagonist|Wee1 signaling pathway|Wee1 assay kit