Thymidylate Synthase

Thymidylate Synthase製品

All (10)
Thymidylate Synthase阻害剤 (10)
新製品

製品コード	製品名称	製品説明	文献中Selleckの製品使用例
S1209	5-FU (5-Fluorouracil)	5-FU (5-Fluorouracil) is a DNA/RNA synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS) in tumor cells. Fluorouracil induces apoptosis and can be used in the treatment of HIV.	Mol Cancer, 2024, 23(1):186 Cancer Discov, 2024, 10.1158/2159-8290.CD-24-0887 Nat Cell Biol, 2024, 10.1038/s41556-024-01473-0
S1135	Pemetrexed disodium	Pemetrexed disodium is a novel antifolate and antimetabolite for TS, DHFR and GARFT with K_i of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. Pemetrexed induces autophagy and apoptosis.	Cell Death Dis, 2024, 15(8):555 Cell Commun Signal, 2024, 22(1):375 Cancer Cell, 2022, 40(10):1128-1144.e8
S5971	Pemetrexed	Pemetrexed (LY231514) is a novel antifolate and antimetabolite for thymidylate synthase (TS), dihydrofolate reductase (DHFR) and glycinamide ribonucleotide formyltransferase (GARFT) with Ki of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. Pemetrexed induces autophagy and apoptosis.	Cancer Discov, 2024, 10.1158/2159-8290.CD-24-0887 Cell Rep Med, 2024, 5(7):101615 Mol Cancer Res, 2024, 22(1):82-93
S1192	Raltitrexed	Raltitrexed (ZD-1694) is a thymidylate synthase inhibitor with an IC50 of 9 nM for the inhibition of L1210 cell growth.	Mol Ther, 2022, S1525-0016(22)00717-1 ACS Chem Neurosci, 2022, 13(17):2646-2657 Biochem Biophys Res Commun, 2022, 610:1-7
S1778	Trifluridine (NSC 75520)	Trifluridine (NSC 529182, NSC 75520, Viroptic, Trifluorothymidine, TFT) is an anti-herpesvirus antiviral agent by interacting viral DNA replication, used primarily on the eye.	Nat Med, 2023, 29(3):605-614 JCI Insight, 2022, 7(22e158060) Biochem Biophys Res Commun, 2022, 610:119-126
S3731	Tipiracil hydrochloride	Tipiracil (MA-1) is an inhibitor of thymidine phosphorylase, the enzyme that degrades trifluridine into trifluorothymidine. Its combination with trifluridine increases the bioavailability of trifluridine.	Cell Mol Immunol, 2022, 10.1038/s41423-022-00842-9 JCI Insight, 2022, 7(22e158060)
S8539	TAS-102	TAS-102 (Trifluridine-Tipiracil Hydrochloride Mixture) is an orally administered combination of a thymidine-based nucleic acid analogue, trifluridine, and a thymidine phosphorylase inhibitor, tipiracil hydrochloride.	STAR Protoc, 2024, 5(2):103090 J Exp Clin Cancer Res, 2023, 42(1):8 Adv Sci (Weinh), 2021, e2103360
S5790	Folinic acid (Leucovorin)	Folinic acid (Leucovorin) is a biological folic acid that increases the level of reduced folates in tissues, which promotes the inhibition of thymidylate synthase (TS).Solutions are unstable and should be fresh-prepared.	Nat Commun, 2022, 13(1):6308
E4818^New	Pemetrexed (disodium heptahydrate)	Pemetrexed (disodium heptahydrate) is a folate antimetabolite that inhibits thymidylate synthase, dihydrofolate reductase and glycinamide ribonucleotide formyltransferase. It also induces apoptosis and cell-cycle arrest in non-small-cell lung cancer carrying an EGFR exon 19 deletion.
S3169	2'-Deoxyuridine 5'-monophosphate disodium salt	2'-Deoxyuridine 5'-monophosphate disodium salt (dUMP) is a substrate for thymidylate synthase and is converted to deoxythymidine monophosphate (dTMP). The inhibition of dUMP to dTMP at the methylation step is a key in controlling bacterial and eukaryotic cell growth.
S1209	5-FU (5-Fluorouracil)	5-FU (5-Fluorouracil) is a DNA/RNA synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS) in tumor cells. Fluorouracil induces apoptosis and can be used in the treatment of HIV.	Mol Cancer, 2024, 23(1):186 Cancer Discov, 2024, 10.1158/2159-8290.CD-24-0887 Nat Cell Biol, 2024, 10.1038/s41556-024-01473-0
S1135	Pemetrexed disodium	Pemetrexed disodium is a novel antifolate and antimetabolite for TS, DHFR and GARFT with K_i of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. Pemetrexed induces autophagy and apoptosis.	Cell Death Dis, 2024, 15(8):555 Cell Commun Signal, 2024, 22(1):375 Cancer Cell, 2022, 40(10):1128-1144.e8
S5971	Pemetrexed	Pemetrexed (LY231514) is a novel antifolate and antimetabolite for thymidylate synthase (TS), dihydrofolate reductase (DHFR) and glycinamide ribonucleotide formyltransferase (GARFT) with Ki of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. Pemetrexed induces autophagy and apoptosis.	Cancer Discov, 2024, 10.1158/2159-8290.CD-24-0887 Cell Rep Med, 2024, 5(7):101615 Mol Cancer Res, 2024, 22(1):82-93
S1192	Raltitrexed	Raltitrexed (ZD-1694) is a thymidylate synthase inhibitor with an IC50 of 9 nM for the inhibition of L1210 cell growth.	Mol Ther, 2022, S1525-0016(22)00717-1 ACS Chem Neurosci, 2022, 13(17):2646-2657 Biochem Biophys Res Commun, 2022, 610:1-7
S1778	Trifluridine (NSC 75520)	Trifluridine (NSC 529182, NSC 75520, Viroptic, Trifluorothymidine, TFT) is an anti-herpesvirus antiviral agent by interacting viral DNA replication, used primarily on the eye.	Nat Med, 2023, 29(3):605-614 JCI Insight, 2022, 7(22e158060) Biochem Biophys Res Commun, 2022, 610:119-126
S3731	Tipiracil hydrochloride	Tipiracil (MA-1) is an inhibitor of thymidine phosphorylase, the enzyme that degrades trifluridine into trifluorothymidine. Its combination with trifluridine increases the bioavailability of trifluridine.	Cell Mol Immunol, 2022, 10.1038/s41423-022-00842-9 JCI Insight, 2022, 7(22e158060)
S8539	TAS-102	TAS-102 (Trifluridine-Tipiracil Hydrochloride Mixture) is an orally administered combination of a thymidine-based nucleic acid analogue, trifluridine, and a thymidine phosphorylase inhibitor, tipiracil hydrochloride.	STAR Protoc, 2024, 5(2):103090 J Exp Clin Cancer Res, 2023, 42(1):8 Adv Sci (Weinh), 2021, e2103360
S5790	Folinic acid (Leucovorin)	Folinic acid (Leucovorin) is a biological folic acid that increases the level of reduced folates in tissues, which promotes the inhibition of thymidylate synthase (TS).Solutions are unstable and should be fresh-prepared.	Nat Commun, 2022, 13(1):6308
E4818^New	Pemetrexed (disodium heptahydrate)	Pemetrexed (disodium heptahydrate) is a folate antimetabolite that inhibits thymidylate synthase, dihydrofolate reductase and glycinamide ribonucleotide formyltransferase. It also induces apoptosis and cell-cycle arrest in non-small-cell lung cancer carrying an EGFR exon 19 deletion.
S3169	2'-Deoxyuridine 5'-monophosphate disodium salt	2'-Deoxyuridine 5'-monophosphate disodium salt (dUMP) is a substrate for thymidylate synthase and is converted to deoxythymidine monophosphate (dTMP). The inhibition of dUMP to dTMP at the methylation step is a key in controlling bacterial and eukaryotic cell growth.
E4818^New	Pemetrexed (disodium heptahydrate)	Pemetrexed (disodium heptahydrate) is a folate antimetabolite that inhibits thymidylate synthase, dihydrofolate reductase and glycinamide ribonucleotide formyltransferase. It also induces apoptosis and cell-cycle arrest in non-small-cell lung cancer carrying an EGFR exon 19 deletion.

Thymidylate Synthase阻害剤の選択性比較