ホームページ DNA Damage/DNA Repair -Epigenetics Sirtuin SIRT2 選択性 阻害剤
  • SIRT1
  • SIRT2
  • SIRT3
  • SIRT6
  • SIRT5

SIRT2 選択性 阻害剤

製品コード 製品名 製品説明 Selective / Pan IC50 / Ki
S2176 Tenovin-3 Tenovin-3 is an inhibitor of SIRT2. Tenovin-3 is able to increase p53 levels in MCF-7 cells. Selective
S8245 Thiomyristoyl Thiomyristoyl (TM) is a potent and specific SIRT2 inhibitor with an IC50 of 28 nM. It inhibits SIRT1 with an IC50 value of 98 μM and does not inhibit SIRT3 even at 200 μM. Selective SIRT2, IC50: 28 nM
S7845 SirReal2 SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM. Selective SIRT2, IC50: 140 nM
S7577 AGK2 AGK2 is a potent, and selective SIRT2 inhibitor with IC50 of 3.5 μM that minimally affects either SIRT1 or SIRT3 at 10-fold higher levels. Selective SIRT2, IC50: 3.5 μM
S5914 AK 7 AK 7 is a brain-permeable selective SIRT2 inhibitor with an IC50 of 15.5 μM. Selective SIRT2, IC50: 15.5 μM
S8628 3-TYP 3-TYP (3-(1H-1,2,3-triazol-4-yl) pyridine) is a selective SIRT3 inhibitor which is selective for Sirt3 over Sirt1 and Sirt2. The IC50 values for SITR1, SIRT2, SIRT3 are 88 nM, 92 nM, 16 nM respectively. Pan SIRT2, IC50: 92 nM
S8942 Suramin sodium salt Suramin sodium salt (Suramin hexasodium salt) is a reversible and competitive protein-tyrosine phosphatase (PTPases) inhibitor, also is the potent inhibitor of sirtuins, purified topoisomerase II and SARS-CoV-2 RNA-dependent RNA polymerase (RdRp). Pan SirT2, IC50: 1.15 μM
S4900 Tenovin-6 Tenovin-6 is a small molecule activator of p53 transcriptional activity and inhibits dihydroorotate dehydrogenase (DHODH). Tenovin-6 is also an inhibitor of SirT1 and SirT2. Pan SIRT2, IC50: 10 μM
S2804 Sirtinol Sirtinol is a specific SIRT1 and SIRT2 inhibitor with IC50 of 131 μM and 38 μM in cell-free assays, respectively. Pan SIRT2, IC50: 38 μM
S8627 OSS_128167 OSS_128167 (SIRT6-IN-1) is a specific SIRT6 inhibitor with IC50 values of 89, 1578 and 751 μM for SIRT6, SIRT1 and SIRT2, respectively. OSS_128167 has anti-viral effect in HBV transcription and replication. Pan SIRT2, IC50: 751 μM
S1396 Resveratrol Resveratrol has a wide spectrum of targets including cyclooxygenases(i.e. COX, IC50=1.1 μM), lipooxygenases（LOX, IC50=2.7 μM）, kinases, sirtuins and other proteins. It has anti-cancer, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects. Resveratrol induces mitophagy/autophagy and autophagy-dependent apoptosis. Pan
S8460 Salermide Salermide is a reverse amide with a strong in vitro inhibitory effect on Sirt1 and Sirt2. Compared with Sirt1, Salermide is even more efficient at inhibiting Sirt2. Pan