ホームページ Metabolism -Immunology & Inflammation IDO/TDO IDO 選択性 阻害剤
  • TDO
  • IDO

IDO 選択性 阻害剤

製品コード 製品名 製品説明 Selective / Pan IC50 / Ki
S8919 LY-3381916 LY-3381916 (IDO1-IN-5) is a brain penetrated, potent and selective Indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor. LY-3381916 exhibits anti-tumor activity. Selective
S8629 Linrodostat (BMS-986205) Linrodostat (BMS-986205, ONO-7701) is an irreversible inhibitor of IDO1 with an IC50 of 1.7 nM. It inhibits kynurenine production with IC50 values of 1.7, 1.1 and > 2000 in human HeLa, HEK293 expressing human IDO-1 and tryptophan-2, 3-dioxygenase cell-based assays. Selective IDO1, IC50: 1.7 nM
S8557 IDO inhibitor 1 IDO inhibitor 1 is a potent inhibitor of IDO (indoleamine-(2,3)-dioxygenase) with IC50 of 3 nM. Selective IDO, IC50: 3 nM
S8957 Navoximod Navoximod (GDC-0919, NLG-919) is a potent inhibitor of IDO (indoleamine-(2,3)-dioxygenase) pathway with Ki of 7 nM and EC50 of 75 nM. Selective IDO, Ki: 7 nM; IDO, EC50: 75 nM
S7910 Epacadostat (INCB024360) Epacadostat (INCB024360) is a potent and selective indoleamine 2,3-dioxygenase (IDO1) inhibitor with IC50 of 10 nM and displays high selectivity over other related enzymes such as IDO2 or tryptophan 2,3-dioxygenase (TDO). Selective IDO1, IC50: 10 nM
S7111 IDO-IN-2 IDO-IN-2 (RG 6078, NLG-919 analogue, GDC-0919 analogue) is a a potent IDO1 inhibitor with IC50 of 38 nM. Selective IDO1, IC50: 38 nM
S6728 IDO-IN-1 IDO-IN-1 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor with an IC50 of 59 nM. Selective IDO, IC50: 59 nM
S7587 Epacadostat (INCB024360) analogue Epacadostat (INCB024360) analogue (INCB14943) is a potent, competitive IDO1 (indoleamine-(2,3)-dioxygenase) inhibitor with IC50 of 67 nM. Selective IDO1, IC50: 67 nM
S8657 PF-06840003 PF-06840003 (EOS200271) is a highly selective orally bioavailable IDO-1 inhibitor. Although it has moderate hIDO1 enzyme inhibition (IC50 0.41 μM), it is a highly efficient compound (LE 0.53, LipE 5.1), driven by its tight packing within the enzyme, as well as the high density of hydrogen bonds it forms with hIDO-1 despite its small size. Selective hIDO-1, IC50: 0.41 μM; mIDO-1, IC50: 1.5 μM; dIDO-1, IC50: 0.59 μM
S5249 Coptisine chloride Coptisine (Q-100696, NSC-119754) is an isoquinoline alkaloid isolated from Coptidis Rhizoma with anti-diabetic, antimicrobial, antiviral, anti-hepatoma, and anti-leukemia effects. Coptisine chloride is an efficient uncompetitive IDO inhibitor with IC50 value of 6.3 μM and Ki value of 5.8 μM. Selective IDO, IC50: 6.3 μM; IDO, Ki: 5.8 μM
S7756 Indoximod (NLG-8189） Indoximod (NLG-8189, 1-Methyl-D-tryptophan, 1-MT), a methylated tryptophan, acts as an IDO (indoleamine-(2,3)-dioxygenase) pathway inhibitor, and reverses IDO-mediated immune suppression. Phase 2.This product has poor solubility, animal experiments are available, cell experiments please choose carefully! Selective