ALK1
ALK2
ALK3
ALK4
TGFβRI/ALK5
ALK6
TGFβRII
TGF-β
Smad3
Smad4
Smad5
ALK7

ALK3 阻害剤

製品コード	製品名	製品説明	Selective / Pan	IC50 / Ki
S2618	LDN-193189	LDN-193189 (DM3189) is a selective BMP signaling inhibitor, inhibits the ALK1, ALK2, ALK3 and ALK6 with IC50s of 0.8 nM, 0.8 nM, 5.3 nM and 16.7 nM in the kinase assay, respectively. LDN-193189 inhibits the transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50s of 5 nM and 30 nM in C2C12 cells, respectively, exhibits 200-fold selectivity for BMP versus TGF-β. For animal testing, the water-soluble	Pan