Phospholipase (e.g. PLA)

Phospholipase (e.g. PLA)製品

• All (18)
• Phospholipase (e.g. PLA)阻害剤 (14)
• Phospholipase (e.g. PLA)活性剤(3)
• Phospholipase (e.g. PLA)拮抗剤(1)
• 新製品

製品コード	製品名称	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S8011	U73122	U73122 is a potent phospholipase C (PLC) inhibitor, which reduces agonist-induced Ca2+ increases in platelets and PMN. U73122 potently inhibits human 5-lipoxygenase (5-LO).	Nat Commun, 2024, 15(1):1300 Autophagy, 2024, 10.1080/15548627.2024.2395797 Cell Rep, 2024, 43(3):113929
S7609	GW4869	GW4869 (GW69A, GW554869A) is a neutral, noncompetitive inhibitor of sphingomyelinase (SMase) with an IC50 of 1 μM. It is selective for N-SMase, and does not inhibit acid SMase at up to at least 150 μM, also is a commonly used exosome inhibitor.	Signal Transduct Target Ther, 2024, 9(1):253 ACS Nano, 2024, 18(5):4241-4255 J Nanobiotechnology, 2024, 22(1):361
S1110	Varespladib (LY315920)	Varespladib (LY315920) is a potent and selective human non-pancreatic secretory phospholipase A2 (hnsPLA) inhibitor with IC50 of 7 nM. Phase 3.	Int J Mol Sci, 2024, 25(19)10649 Front Immunol, 2022, 13:824746 J Med Chem, 2019, 62(4):1999-2007
S2364	Tanshinone I	Tanshinone I, an active principle isolated from Salvia miltiorrhiza (Danshen), is structurally similar to tanshinone IIA and may possess similar cytotoxic effects on tumor cells.	Int J Oncol, 2023, 63(1)76 Phytomedicine, 2022, 98:153958 Drug Des Devel Ther, 2022, 16:3197-3213
S7520	Darapladib	Darapladib is a reversible lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor with IC50 of 0.25 nM. Phase 3.	iScience, 2024, 27(5):109774 Nat Commun, 2023, 14(1):5728 Nat Commun, 2023, 14(1):5728
S4107	Clofazimine	Clofazimine (NSC-141046) is a rhimophenazine dye, originally developed for the treatment of tuberculosis, it has both antimicrobial and antiinflammatory activity, postulated mechanisms of action include intercalation of clofazimine with bacterial DNA and increasing levels of cellular phospholipase A2.	Viruses, 2024, 16(4)640 Cell Rep Methods, 2023, 3(10):100599 Blood, 2022, blood.2021014304
S4255	Quinacrine 2HCl	Quinacrine 2HCl(Quinacrine dihydrochloride) is a lipophilic cationic drug with multiple actions that is commonly used as an anti-protozoal agent. Quinacrine is an effective phospholipase A2 inhibitor.	Molecules, 2022, 27(17)5561 Toxicol In Vitro, 2022, 83:105420 Mol Oncol, 2020, 10.1002/1878-0261.12853
S2390	Polydatin	Polydatin (Piceid) is a crystal component extracted from the root stem of perennial herbage Polygonum Cuspidatum Sieb.et Zucc.	Biochem Biophys Res Commun, 2021, 556:149-155 J Med Virol, 2019, 91(8):1440-1447
S0053	CAY10593 (VU0155069)	CAY10593 (VU0155069) is a selective phospholipase D1 (PLD1) antagonist that impairs human P2X7 acivation.	Free Radic Biol Med, 2021, S0891-5849(21)00821-2
S0982	m-3M3FBS	m-3M3FBS is a potent activator of phospholipase C (PLC) that stimulates a transient intracellular calcium concentration increase in neutrophils. m-3M3FBS induces apoptosis in monocytic leukemia cells.	Pharmaceuticals (Basel), 2022, 15(12)1444
S9794	Melittin	Melittin (MLT, Forapin, Forapine) is an activator of phospholipase A2 (PLA2) that stimulates the activity of the low molecular weight PLA2, while it does not the increase the activity of the high molecular weight enzyme.	Nutr Res Pract, 2024, 18(2):210-222 EMBO J, 2022, e110439
S3220	Trigonelline	Trigonelline (Trigenolline) is a plant alkaloid and a major component of coffee and fenugreek with anti-degranulation, anti-diabetic, antioxidant, anti-inflammatory, and neuroprotective effects. Trigonelline inhibits FcεRI-mediated intracellular signaling pathways, such as phosphorylation of PLCγ1, PI3K, and Akt. Trigonelline (Trigenolline) also inhibits the microtubule formation in RBL-2H3 cells.	Biomed Pharmacother, 2021, 143:112204
S6522	ST 271	ST271 is a tyrphostin-like protein tyrosine kinase (PTK) inhibitor which inhibits phospholipase D (PLD) activity.
S7321	FIPI	FIPI (5-Fluoro-2-indolyl deschlorohalopemide), a derivative of halopemide, is a potent and selective inhibitor of phospholipase D with IC50 of 25 nM and 20 nM for PLD1 and PLD2, respectively.	Cell Chem Biol, 2024, S2451-9456(24)00090-4
S9478	Trans-4-Phenyl-3-buten-2-one	Trans-4-Phenyl-3-buten-2-one (trans-Benzylideneacetone, trans-Benzalacetone, trans-Benzylideneacetone) is an inhibitor of the enzyme phospholipase A2 (PLA2). Trans-4-Phenyl-3-buten-2-one is used as a flavouring agent, a fragrance and a bacterial metabolite.
S6564	ML348	ML348 (GNF-Pf-1127) is a potent and selective APT1 (Acyl protein thioesterase 1)/lysophospholipase 1 (LYPLA1) inhibitor with Ki values of 280 nM and >10 μM for APT1 and APT2, respectively.
S0766	RHC 80267	RHC 80267 (U-57908) is a potent and selective inhibitor of diacylglycerol lipase (DAGL, DAG lipase) with IC50 of 4 μM for cholinesterase activity. RHC 80267 inhibits cyclooxygenase (COX) activity, phospholipase C (PLC) activity and the hydrolysis of phosphatidylcholine (PC).
S5913	Cambinol	Cambinol is a novel uncompetitive nSMase2 inhibitor with a K i value of 7 μM (IC50 = 5 ± 1 μM).
S8011	U73122	U73122 is a potent phospholipase C (PLC) inhibitor, which reduces agonist-induced Ca2+ increases in platelets and PMN. U73122 potently inhibits human 5-lipoxygenase (5-LO).	Nat Commun, 2024, 15(1):1300 Autophagy, 2024, 10.1080/15548627.2024.2395797 Cell Rep, 2024, 43(3):113929
S7609	GW4869	GW4869 (GW69A, GW554869A) is a neutral, noncompetitive inhibitor of sphingomyelinase (SMase) with an IC50 of 1 μM. It is selective for N-SMase, and does not inhibit acid SMase at up to at least 150 μM, also is a commonly used exosome inhibitor.	Signal Transduct Target Ther, 2024, 9(1):253 ACS Nano, 2024, 18(5):4241-4255 J Nanobiotechnology, 2024, 22(1):361
S1110	Varespladib (LY315920)	Varespladib (LY315920) is a potent and selective human non-pancreatic secretory phospholipase A2 (hnsPLA) inhibitor with IC50 of 7 nM. Phase 3.	Int J Mol Sci, 2024, 25(19)10649 Front Immunol, 2022, 13:824746 J Med Chem, 2019, 62(4):1999-2007
S2364	Tanshinone I	Tanshinone I, an active principle isolated from Salvia miltiorrhiza (Danshen), is structurally similar to tanshinone IIA and may possess similar cytotoxic effects on tumor cells.	Int J Oncol, 2023, 63(1)76 Phytomedicine, 2022, 98:153958 Drug Des Devel Ther, 2022, 16:3197-3213
S7520	Darapladib	Darapladib is a reversible lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor with IC50 of 0.25 nM. Phase 3.	iScience, 2024, 27(5):109774 Nat Commun, 2023, 14(1):5728 Nat Commun, 2023, 14(1):5728
S4255	Quinacrine 2HCl	Quinacrine 2HCl(Quinacrine dihydrochloride) is a lipophilic cationic drug with multiple actions that is commonly used as an anti-protozoal agent. Quinacrine is an effective phospholipase A2 inhibitor.	Molecules, 2022, 27(17)5561 Toxicol In Vitro, 2022, 83:105420 Mol Oncol, 2020, 10.1002/1878-0261.12853
S2390	Polydatin	Polydatin (Piceid) is a crystal component extracted from the root stem of perennial herbage Polygonum Cuspidatum Sieb.et Zucc.	Biochem Biophys Res Commun, 2021, 556:149-155 J Med Virol, 2019, 91(8):1440-1447
S3220	Trigonelline	Trigonelline (Trigenolline) is a plant alkaloid and a major component of coffee and fenugreek with anti-degranulation, anti-diabetic, antioxidant, anti-inflammatory, and neuroprotective effects. Trigonelline inhibits FcεRI-mediated intracellular signaling pathways, such as phosphorylation of PLCγ1, PI3K, and Akt. Trigonelline (Trigenolline) also inhibits the microtubule formation in RBL-2H3 cells.	Biomed Pharmacother, 2021, 143:112204
S6522	ST 271	ST271 is a tyrphostin-like protein tyrosine kinase (PTK) inhibitor which inhibits phospholipase D (PLD) activity.
S7321	FIPI	FIPI (5-Fluoro-2-indolyl deschlorohalopemide), a derivative of halopemide, is a potent and selective inhibitor of phospholipase D with IC50 of 25 nM and 20 nM for PLD1 and PLD2, respectively.	Cell Chem Biol, 2024, S2451-9456(24)00090-4
S9478	Trans-4-Phenyl-3-buten-2-one	Trans-4-Phenyl-3-buten-2-one (trans-Benzylideneacetone, trans-Benzalacetone, trans-Benzylideneacetone) is an inhibitor of the enzyme phospholipase A2 (PLA2). Trans-4-Phenyl-3-buten-2-one is used as a flavouring agent, a fragrance and a bacterial metabolite.
S6564	ML348	ML348 (GNF-Pf-1127) is a potent and selective APT1 (Acyl protein thioesterase 1)/lysophospholipase 1 (LYPLA1) inhibitor with Ki values of 280 nM and >10 μM for APT1 and APT2, respectively.
S0766	RHC 80267	RHC 80267 (U-57908) is a potent and selective inhibitor of diacylglycerol lipase (DAGL, DAG lipase) with IC50 of 4 μM for cholinesterase activity. RHC 80267 inhibits cyclooxygenase (COX) activity, phospholipase C (PLC) activity and the hydrolysis of phosphatidylcholine (PC).
S5913	Cambinol	Cambinol is a novel uncompetitive nSMase2 inhibitor with a K i value of 7 μM (IC50 = 5 ± 1 μM).
S4107	Clofazimine	Clofazimine (NSC-141046) is a rhimophenazine dye, originally developed for the treatment of tuberculosis, it has both antimicrobial and antiinflammatory activity, postulated mechanisms of action include intercalation of clofazimine with bacterial DNA and increasing levels of cellular phospholipase A2.	Viruses, 2024, 16(4)640 Cell Rep Methods, 2023, 3(10):100599 Blood, 2022, blood.2021014304
S0982	m-3M3FBS	m-3M3FBS is a potent activator of phospholipase C (PLC) that stimulates a transient intracellular calcium concentration increase in neutrophils. m-3M3FBS induces apoptosis in monocytic leukemia cells.	Pharmaceuticals (Basel), 2022, 15(12)1444
S9794	Melittin	Melittin (MLT, Forapin, Forapine) is an activator of phospholipase A2 (PLA2) that stimulates the activity of the low molecular weight PLA2, while it does not the increase the activity of the high molecular weight enzyme.	Nutr Res Pract, 2024, 18(2):210-222 EMBO J, 2022, e110439
S0053	CAY10593 (VU0155069)	CAY10593 (VU0155069) is a selective phospholipase D1 (PLD1) antagonist that impairs human P2X7 acivation.	Free Radic Biol Med, 2021, S0891-5849(21)00821-2