ホームページ DNA Damage/DNA Repair Antineoplastic and Immunosuppressive Antibiotics chemical - Topoisomerase inhibitor - Autophagy activator - Mitophagy activator - Apoptosis related activator Etoposide For research use only.

Etoposide

別名：VP-16213,VP-16

Etoposide is a semisynthetic derivative of podophyllotoxin, which inhibits DNA synthesis via topoisomerase II inhibition activity which enhances double-strand and single-strand cleavage of DNA and reversibly inhibits repair by topoisomerase II binding. Etoposide induces autophagy, mitophagy and apoptosis.

Etoposide化学構造

CAS No. 33419-42-0

サイズ 価格(税別) 在庫状況
10mM (1mL in DMSO) JPY 29500 国内在庫あり
JPY 22000 国内在庫あり
JPY 56500 国内在庫あり
JPY 86500 国内在庫なし(納期7~10日)
JPY 295500 国内在庫なし(納期7~10日)

代表番号: 045-509-1970|電子メール：[email protected]
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製品安全説明書

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Etoposide関連製品

Antineoplastic and Immunosuppressive Antibiotics阻害剤の選択性比較

Cell Data

Cell Lines Assay Type Concentration Incubation Time 活性情報 PMID
HT1080 Growth Inhibition Assay 1-100 μM 4/24/48 h induces cell death significantly in a very low concentration 25078064
MCF7 BMI1 Function Assay 10-100 μM 2 h ETOP induces ATM activation 25088203
MCF7 EV Function Assay 10-100 μM 2 h ETOP induces ATM activation 25088203
MCF 7BMI1 Function Assay 10-100 μM 2 h induces production of γH2AX 25088203
MCF7 EV Function Assay 10-100 μM 2 h induces production of γH2AX 25088203
MKL-1  Function Assay 10-1000 nM 4 d induces the induction of MHC-I expression 25116754
NSCs Growth Inhibition Assay 0.01-300 μM 48 h IC50=0.3-3 μM 25119185
UW228-3 Growth Inhibition Assay 0.01-300 μM 48 h IC50=0.99 μM 25119185
DU145 stem-like Function Assay 10-100 μM 2 h increases the pCHK1 expression and decreases the pCHK1 expression in a dose-dependent manner 25149681
DU145 Function Assay 10-100 μM 2 h increases the pCHK1 expression and decreases the pCHK1 expression in a dose-dependent manner 25149681
DU145 stem-like Apoptosis Assay 10-100 μM 8 h induces cell death in a dose-dependent manner 25149681
DU145 Apoptosis Assay 10-100 μM 8 h induces cell death significantly in a very low concentration 25149681
SH-EP  Function Assay 20 μg/ml 24 h increases the expression of endogenous DEPP 25261981
MCF7  Growth Inhibition Assay 5-100 μM 7 d inhibits cell growth in a dose-dependent manner 25472619
SMMC-7721 Function Assay 40 μM 48 h induces γH2AX foci formation 25544361
Hep3B  Function Assay 0.1-10 μM 24 h suppresses the expression of hepcidin mRNA 25633564
Hep3B  Function Assay 10 μM 48 h  reduces the enhancing effect of BMP-6 25633564
HEK293T Growth Inhibition Assay 1-5 μM 48 h  IC50=2.42 ± 0.05 μM 25746763
SW480 Growth Inhibition Assay 0.5-2.5 μM 48 h  IC50=4.92 ± 0.33 μM 25746763
COLO 205 Growth Inhibition Assay 0.5-2.5 μM 48 h  IC50=1.61 ± 0.02 μM 25746763
Caco2 Growth Inhibition Assay 0.5-2.5 μM 48 h  IC50=7.26 ± 1.68 μM 25746763
HT-29 Growth Inhibition Assay 0.5-2.5 μM 48 h  IC50=7.2 ± 1.04 μM 25746763
HCT116 Growth Inhibition Assay 0.5-2.5 μM 48 h  IC50=1.73 ± 0.21 μM 25746763
U87 Growth Inhibition Assay 0-50 μM 48 h decreases cell viability which can be enhanced by silibinin 25750273
HT1080 Function Assay 0.0001-100 μM 1-24 h induces p-p53(ser15) in both time- and concentration-dependent manner 25078064
HT1080 Growth Inhibition Assay 0.0001-100 μM 24 h causes an increase in the number of cells in G2/M, while decreasing S and G1 phase cells 25078064
Kelly Growth Inhibition Assay 0-10 μM 72 h IC50=1.518 μM 25008900
SH-SY5Y  Growth Inhibition Assay 0-10 μM 72 h IC50=0.754 μM  25008900
SK-N-AS Growth Inhibition Assay 0-10 μM 72 h IC50=1.712 μM  25008900
SK-N-DZ Growth Inhibition Assay 0-10 μM 72 h IC50=5.485 μM 25008900
MDA-MB-231 Growth Inhibition Assay 48 h  IC50=12.8 ± 1.0 μM 25216378
T-47D Growth Inhibition Assay 48 h  IC50=7.7 ± 0.7 μM 25216378
MCF-7 Growth Inhibition Assay 48 h  IC50=7.2 ± 0.8 μM 25216378
FaDu Growth Inhibition Assay 72 h IC50=5.02 ± 1.15 μM 25220729
CAL27 Growth Inhibition Assay 72 h IC50=4.27 ± 1.14 μM 25220729
SCC25 Growth Inhibition Assay 72 h IC50=8.41 ± 1.11 μM 25220729
FaDu Growth Inhibition Assay 48 h IC50=6.43 ± 1.13 μM 25220729
CAL27 Growth Inhibition Assay 48 h IC50=18.24 ± 1.15 μM 25220729
SCC25 Growth Inhibition Assay 48 h IC50=20.86 ± 1.07 μM 25220729
FaDu Growth Inhibition Assay 24 h IC50=25.89 ± 1.13 μM 25220729
CAL27 Growth Inhibition Assay 24 h IC50=52.1 ± 1.09 μM 25220729
SCC25 Growth Inhibition Assay 24 h IC50=43.3 ± 1.12 μM 25220729
K/VP.5 Growth Inhibition Assay 72 h IC50=4.9 μM 25282653
K562 Growth Inhibition Assay 72 h IC50=0.29 μM 25282653
HeLa Growth Inhibition Assay 72 h IC50=3.9 ± 2.3 μM 25486219
Jurkat Growth Inhibition Assay 72 h IC50=1.2 ± 1.5 μM 25486219
MCF-7 Growth Inhibition Assay 72 h IC50=10.9 ± 2.1 μM 25486219
MDA-MB-231 Growth Inhibition Assay 72 h IC50=21.2 ± 4.2 μM 25486219
HD-MY-Z Growth Inhibition Assay 24/48/72 h IC50＞100 μM 25048236
DOHH-2 Growth Inhibition Assay 24 h IC50＞100 μM 25048236
DOHH-2 Growth Inhibition Assay 48 h IC50=19.9 μM 25048236
DOHH-2 Growth Inhibition Assay 72 h IC50=5 μM 25048236
REH Growth Inhibition Assay 24 h IC50=0.027 μM 25048236
REH Growth Inhibition Assay 48 h IC50=0.014 μM 25048236
REH Growth Inhibition Assay 72 h IC50=0.015 μM 25048236
HH Growth Inhibition Assay 24 h IC50=104.7 μM 25048236
HH Growth Inhibition Assay 48 h IC50=48.6 μM 25048236
HH Growth Inhibition Assay 72 h IC50=14.7 μM 25048236
HuT-78 Growth Inhibition Assay 24 h IC50=9.3 μM 25048236
HuT-78 Growth Inhibition Assay 48 h IC50=4.3 μM 25048236
HuT-78 Growth Inhibition Assay 72 h IC50=4.2 μM 25048236
OPM-2 Growth Inhibition Assay 24 h IC50=24.1 μM 25048236
OPM-2 Growth Inhibition Assay 48 h IC50=4 μM 25048236
OPM-2 Growth Inhibition Assay 72 h IC50=1.3 μM 25048236
RPMI-8226 Growth Inhibition Assay 24 h IC50=106.6 μM 25048236
RPMI-8226 Growth Inhibition Assay 48 h IC50=91.1 μM 25048236
RPMI-8226 Growth Inhibition Assay 72 h IC50=14.9 μM 25048236
U-266 Growth Inhibition Assay 24 h IC50=86.2 μM 25048236
U-266 Growth Inhibition Assay 48 h IC50=68.4 μM 25048236
U-266 Growth Inhibition Assay 72 h IC50=27.4 μM 25048236
HepG2 Growth Inhibition Assay 48 h IC50=13.65 ± 0.92 μM 24996136
A549 Growth Inhibition Assay 48 h IC50=241.9 ± 31.23 μM 24996136
MCF7 Growth Inhibition Assay 48 h IC50=81.09 ± 14.21 μM 24996136
HL-60  Growth Inhibition Assay 72 h IC50=0.12 μM 24993014
HL-60[R] Growth Inhibition Assay 72 h IC50=3.12 μM 24993014
MO59K  Growth Inhibition Assay 7 d IC50=0.17 μM 24953561
MO59J Growth Inhibition Assay 7 d IC50=0.1 μM 24953561
ME 180 Growth Inhibition Assay 48 h  IC50=8.9 ± 0.3 μM 24953027
MCF-7 Growth Inhibition Assay 48 h  IC50=23.9 ± 0.3 μM 24953027
HeLa Growth Inhibition Assay 48 h  IC50=4.71 ± 1.4 μM 24953027
MDA-MB-453 Growth Inhibition Assay 48 h  IC50=12.5 ± 0.85 μM 24953027
MDA-MB-231 Growth Inhibition Assay 48 h  IC50=24.22 ± 2.94 μM 24953027
PC-3 Growth Inhibition Assay 48 h  IC50=14.4 ± 3.23 μM 24953027
HT-29 Growth Inhibition Assay 48 h  IC50=21.45 ± 3.87 μM 24953027
BGC-823 Growth Inhibition Assay 48 h  IC50=43.74 ± 5.13 μM 24793877
HeLa Growth Inhibition Assay 48 h  IC50=209.90 ± 13.42  μM 24793877
A549 Growth Inhibition Assay 48 h  IC50=139.54 ± 7.05 μM 24793877
HK-2 Growth Inhibition Assay 48 h  IC50=9.17 ± 1.58 μM 24793877
KB Cytotoxicity assay 3 days Cytotoxicity against human KB cells assessed as reduction in cell number after 3 days, ID50 = 0.2 μM. 1331331
KB Cytotoxicity assay 3 days In vitro cytotoxicity against KB cells after a 3-day incubation., ID50 = 0.2 μM. 2158562
KB Cytotoxicity assay 3 days Cytotoxicity against KB cells after a 3 day incubation, ID50 = 0.2 μM. 8120864
P388 Cytotoxicity assay 1 hr In vitro cytotoxicity against P388 murine leukemia cells in culture in a clonogenic assay after 1 hour exposure to drug, IC50 = 0.3 μM. 8410993
Bel7402 Cytotoxicity assay 5 days Cytotoxicity against human Bel7402 cells after 5 days by MTT assay, IC50 = 1.9 μM. 8778240
BGC Cytotoxicity assay 5 days Cytotoxicity against human BGC cells after 5 days by MTT assay, IC50 = 6.7 μM. 8778240
HCT8 Cytotoxicity assay 5 days Cytotoxicity against human HCT8 cells after 5 days by MTT assay, IC50 = 6.4 μM. 8778240
HL60 Cytotoxicity assay 5 days Cytotoxicity against human HL60 cells after 5 days by MTT assay, IC50 = 0.16 μM. 8778240
C6 Cytotoxicity assay 3 days Cytotoxicity against rat C6 cells after 3 days treated 4 hrs before db-cAMP challenge by MTT assay, LC50 = 0.12 μM. 8988604
HL-60 Cytotoxicity assay 72 hrs Cytotoxicity against human HL60 cells after 72 hrs by MTT assay, IC50 = 0.025 μM. 11170674
HT-29 Cytotoxicity assay 72 hrs Cytotoxicity against human HT-29 cells after 72 hrs by methylene blue assay, IC50 = 2.3 μM. 14738395
KB Cytotoxicity assay 72 hrs Cytotoxicity against human KB cells after 72 hrs by methylene blue assay, IC50 = 1.1 μM. 14738395
KB Function assay 3 days Dose required for reduction in camptothecin resistant human nasopharyngeal KB cancer cells after 3 days incubation, ED50 = 7 μM. 15456257
KB-7d Function assay 3 days Dose required for reduction in etoposide resistant human nasopharyngeal KB-7d cancer cells after 3 days incubation, ED50 = 17.2 μM. 15456257
A549 Function assay 3 days Dose required for reduction in human lung A549 cancer cells after 3 days incubation, ED50 = 10.6 μM. 15456257
KB Function assay 3 days Dose required to cause reduction in human nasopharyngeal KB cancer cells after 3 days incubation, ED50 = 0.3 μM. 15456257
1A9 Function assay 3 days Dose required to cause reduction in human ovarian 1A9 cancer cells after 3 days incubation, ED50 = 0.15 μM. 15456257
HSC2 Cytotoxicity assay 24 hrs Cytotoxicity against human HSC2 cells assessed as cell viability after 24 hrs, IC50 = 41 μM. 15620262
HL60 Cytotoxicity assay 24 hrs Cytotoxicity against human HL60 cells after 24 hrs by MTT assay, IC50 = 25 μM. 15974617
MCF7 Cytotoxicity assay 48 hrs Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay, IC50 = 0.8775 μM. 16309315
TK10 Cytotoxicity assay 48 hrs Cytotoxicity against human TK10 cells after 48 hrs by SRB assay, IC50 = 9.9525 μM. 16309315
UACC62 Cytotoxicity assay 48 hrs Cytotoxicity against human UACC62 cells after 48 hrs by SRB assay, IC50 = 1.13 μM. 16309315
A549 Cytotoxicity assay 72 hrs Cytotoxicity against human A549 cells after 72 hrs by MTT assay, ED50 = 3.76 μM. 16441087
HeLa Antiproliferative assay 69 hrs Antiproliferative effect against human HeLa cells after 69 hrs by MTT assay, IC50 = 3.6 μM. 16499324
HL60 Antiproliferative assay 69 hrs Antiproliferative effect against human HL60 cells after 69 hrs, IC50 = 0.21 μM. 16499324
MCF7 Antiproliferative assay 72 hrs Antiproliferative effect against human MCF7 cells after 72 hrs by MTT assay, IC50 = 0.19 μM. 16499324
K-562 Cytotoxicity assay 72 hrs Cytotoxicity against human K-562 cells after 72 hrs by MTT assay, IC50 = 1.87 μM. 16872135
LAMA-84 Cytotoxicity assay 72 hrs Cytotoxicity against human LAMA-84 cells after 72 hrs by MTT assay, IC50 = 0.79 μM. 16872135
SKW3 Cytotoxicity assay 72 hrs Cytotoxicity against human SKW3 cells after 72 hrs by MTT assay, IC50 = 0.82 μM. 16872135
HL-60 Cytotoxicity assay 72 hrs Cytotoxicity against human HL-60 cells after 72 hrs by MTT assay, IC50 = 10.5 μM. 16933865
HSC2 Cytotoxicity assay 24 hrs Cytotoxicity against human HSC2 cells after 24 hrs by MTT assay, IC50 = 24 μM. 17125230
KB Cytotoxicity assay 72 hrs Cytotoxicity against human KB cells after 72 hrs, IC50 = 2 μM. 17125231
MCF7 Cytotoxicity assay 48 hrs Cytotoxic activity against human MCF7 cells after 48 hrs by MTT reduction assay, IC50 = 3.2 μM. 17316916
K562 Growth inhibition assay 5 days Growth inhibition of K562 cells by XTT assay after 5 days, IC50 = 0.32 μM. 17411092
BV173 Cytotoxicity assay 72 hrs Cytotoxicity against human BV173 cells after 72 hrs by MTT assay, IC50 = 0.9 μM. 17459529
K562 Cytotoxicity assay 72 hrs Cytotoxicity against human K562 cells after 72 hrs by MTT assay, IC50 = 3.1 μM. 17459529
A549 Cytotoxicity assay 48 hrs Cytotoxicity against human A549 cells after 48 hrs by SRB method, IC50 = 0.32 μM. 17493824
HCT15 Cytotoxicity assay 48 hrs Cytotoxicity against human HCT15 cells after 48 hrs by SRB method, IC50 = 2.43 μM. 17493824
SK-MEL-2 Cytotoxicity assay 48 hrs Cytotoxicity against human SK-MEL-2 cells after 48 hrs by SRB method, IC50 = 0.3 μM. 17493824
SKOV3 Cytotoxicity assay 48 hrs Cytotoxicity against human SKOV3 cells after 48 hrs by SRB method, IC50 = 1.72 μM. 17493824
HL20 Growth inhibition assay 48 hrs Inhibition of cell growth in human HL20 cells after 48 hrs by MTT assay, IC50 = 0.315 μM. 17889547
HeLa Growth inhibition assay 48 hrs Growth inhibition of HeLa cells after 48 hrs by MTT assay, GI50 = 8 μM. 17894480
HeLa Antitumor assay 72 hrs Antitumor activity against human HeLa cells after 72 hrs by MTT assay, IC50 = 3 μM. 17935309
MiaPaCa2 Antitumor assay 72 hrs Antitumor activity against human MiaPaCa2 cells after 72 hrs by MTT assay, IC50 = 15 μM. 17935309
SW620 Antitumor assay 72 hrs Antitumor activity against human SW620 cells after 72 hrs by MTT assay, IC50 = 20 μM. 17935309
HL60 Cytotoxicity assay 48 hrs Cytotoxicity against human HL60 cells after 48 hrs by MTT assay, GI50 = 0.14 μM. 17962028
K562 Cytotoxicity assay 5 days Cytotoxicity against human K562 cells after 5 days by XTT assay, IC50 = 0.32 μM. 18076140
HeLa Cytotoxicity assay 48 hrs Cytotoxicity against human HeLa cells after 48 hrs by MTT assay, IC50 = 2.9 μM. 18258438
AGS Antitumor assay 72 hrs Antitumor against human AGS cells after 72 hrs by MTT assay, IC50 = 0.36 μM. 18299197
HL60 Antitumor assay 72 hrs Antitumor against human HL60 cells after 72 hrs by MTT assay, IC50 = 0.8 μM. 18299197
J82 Antitumor assay 72 hrs Antitumor against human J82 cells after 72 hrs by MTT assay, IC50 = 2.8 μM. 18299197
SK-MES1 Antitumor assay 72 hrs Antitumor against human SK-MES1 cells after 72 hrs by MTT assay, IC50 = 2.5 μM. 18299197
MRC5 Cytotoxicity assay 72 hrs Cytotoxicity against human MRC5 cells after 72 hrs by MTT assay, IC50 = 3.9 μM. 18299197
H520 Cytotoxicity assay 72 hrs Cytotoxicity against human H520 cells after 72 hrs by Cell Titer 96 Aqueous Non-Radioactive assay, GI50 = 8.7 μM. 18321710
PC3 Cytotoxicity assay 72 hrs Cytotoxicity against human PC3 cells after 72 hrs by Cell Titer 96 Aqueous Non-Radioactive assay, GI50 = 11.1 μM. 18321710
A549 Cytotoxicity assay 3 days Cytotoxicity against human A549 cells after 3 days by SRB assay, IC50 = 1.16 μM. 18321715
HCT15 Cytotoxicity assay 3 days Cytotoxicity against human HCT15 cells after 3 days by SRB assay, IC50 = 2.8 μM. 18321715
HL60 Cytotoxicity assay 3 days Cytotoxicity against human HL60 cells after 3 days by SRB assay, IC50 = 0.37 μM. 18321715
HT1080 Cytotoxicity assay 3 days Cytotoxicity against human HT1080 cells after 3 days by SRB assay, IC50 = 0.25 μM. 18321715
SK-MEL-2 Cytotoxicity assay 3 days Cytotoxicity against human SK-MEL-2 cells after 3 days by SRB assay, IC50 = 5.72 μM. 18321715
SKOV3 Cytotoxicity assay 3 days Cytotoxicity against human SKOV3 cells after 3 days by SRB assay, IC50 = 4.28 μM. 18321715
SNU638 Cytotoxicity assay 3 days Cytotoxicity against human SNU638 cells after 3 days by SRB assay, IC50 = 0.23 μM. 18321715
XF498 Cytotoxicity assay 3 days Cytotoxicity against human XF498 cells after 3 days by SRB assay, IC50 = 3.48 μM. 18321715
HL60 Apoptosis assay 48 hrs Induction of apoptosis in human HL60 cells after 48 hrs, AC50 = 0.4 μM. 18339455
5637 Antiproliferative assay 96 hrs Antiproliferative activity against human 5637 cells after 96 hrs by crystal violet assay, IC50 = 0.54 μM. 18434163
A427 Antiproliferative assay 96 hrs Antiproliferative activity against human A427 cells after 96 hrs by crystal violet assay, IC50 = 0.13 μM. 18434163
KYSE70 Antiproliferative assay 96 hrs Antiproliferative activity against human KYSE70 cells after 96 hrs by crystal violet assay, IC50 = 0.94 μM. 18434163
MCF7 Antiproliferative assay 96 hrs Antiproliferative activity against human MCF7 cells after 96 hrs by crystal violet assay, IC50 = 0.5 μM. 18434163
HL60 Cytotoxicity assay 72 hrs Cytotoxicity against human mitoxantrone-sensitive HL60 cells after 72 hrs, IC50 = 0.486 μM. 18507368
HL60/MX2 Cytotoxicity assay 72 hrs Cytotoxicity against mitoxantrone-resistant human HL60/MX2 cells after 72 hrs, IC50 = 48.5 μM. 18507368
HL60 Cytotoxicity assay 72 hrs Cytotoxicity against human HL60 cells after 72 hrs by MTT assay, IC50 = 0.2 μM. 18507472
HL60 Antiproliferative assay 48 hrs Antiproliferative activity against human HL60 cells after 48 hrs by MTT assay, IC50 = 0.315 μM. 18513974
K562 Antiproliferative assay 48 hrs Antiproliferative activity against human K562 cells after 48 hrs by MTT assay, IC50 = 1.27 μM. 18514972
KB Antiproliferative assay 48 hrs Antiproliferative activity against human KB cells after 48 hrs by MTT assay, IC50 = 0.42 μM. 18514972
L02 Antiproliferative assay 48 hrs Antiproliferative activity against human L02 cells after 48 hrs by MTT assay, IC50 = 13 μM. 18514972
DU145 ATCC HTB 81 Cytotoxicity assay 72 hrs Cytotoxicity against human DU145 ATCC HTB 81 cells after 72 hrs by MTT assay, IC50 = 1.5 μM. 18558490
K562 ATCC CCL 243 Cytotoxicity assay 72 hrs Cytotoxicity against human K562 ATCC CCL 243 cells after 72 hrs by MTT assay, IC50 = 4.9 μM. 18558490
MCF7 ATCC HTB 22 Cytotoxicity assay 72 hrs Cytotoxicity against human MCF7 ATCC HTB 22 cells after 72 hrs by MTT assay, IC50 = 12.2 μM. 18558490
U251 RCB 0641 Cytotoxicity assay 72 hrs Cytotoxicity against human U251 RCB 0641 cells after 72 hrs by MTT assay, IC50 = 0.5 μM. 18558490
3LL CRL 1642 Cytotoxicity assay 48 hrs Cytotoxicity against mouse 3LL CRL 1642 cells after 48 hrs by MTT assay, IC50 = 4 μM. 18558490
L1210 ATCC CCL 219 Cytotoxicity assay 48 hrs Cytotoxicity against mouse L1210 ATCC CCL 219 cells after 48 hrs by MTT assay, IC50 = 0.5 μM. 18558490
A549 Cytotoxicity assay 72 hrs Cytotoxicity against human A549 cells after 72 hrs by MTT assay, IC50 = 8.37 μM. 18844422
KB Cytotoxicity assay 72 hrs Cytotoxicity against human KB cells after 72 hrs by MTT assay, IC50 = 1.25 μM. 18844422
AGS Cytotoxicity assay 3 days Cytotoxicity against human AGS cells after 3 days by MTT assay, IC50 = 0.36 μM. 19013074
HL-60 Cytotoxicity assay 3 days Cytotoxicity against human HL-60 cells after 3 days by MTT assay, IC50 = 0.8 μM. 19013074
J82 Cytotoxicity assay 3 days Cytotoxicity against human J82 cells after 3 days by MTT assay, IC50 = 2.8 μM. 19013074
MRC5 Cytotoxicity assay 3 days Cytotoxicity against human MRC5 cells after 3 days by MTT assay, IC50 = 3.9 μM. 19013074
SK-MES-1 Cytotoxicity assay 3 days Cytotoxicity against human SK-MES-1 cells after 3 days by MTT assay, IC50 = 2.5 μM. 19013074
A549 Cytotoxicity assay 72 hrs Cytotoxicity against human A549 cells after 72 hrs by MTT assay, IC50 = 5.9 μM. 19053514
HL-60 Cytotoxicity assay 72 hrs Cytotoxicity against human HL-60 cells after 72 hrs by MTT assay, IC50 = 0.25 μM. 19053514
U937 Cytotoxicity assay 72 hrs Cytotoxicity against human U937 cells after 72 hrs by MTT assay, IC50 = 0.92 μM. 19053514
ACHN Antiproliferative assay 96 hrs Antiproliferative activity against human ACHN cells after 96 hrs by MTT assay, IC50 = 2.15 μM. 19053767
CCRF-CEM Antiproliferative assay 96 hrs Antiproliferative activity against human CCRF-CEM cells after 96 hrs by MTT assay, IC50 = 1.2 μM. 19053767
CCRF-SB Antiproliferative assay 96 hrs Antiproliferative activity against human CCRF-SB cells after 96 hrs by MTT assay, IC50 = 0.1 μM. 19053767
HeLa Antiproliferative assay 96 hrs Antiproliferative activity against human HeLa cells after 96 hrs by MTT assay, IC50 = 3 μM. 19053767
HT-29 Antiproliferative assay 96 hrs Antiproliferative activity against human HT-29 cells after 96 hrs by MTT assay, IC50 = 2.5 μM. 19053767
MCF7 Antiproliferative assay 96 hrs Antiproliferative activity against human MCF7 cells after 96 hrs by MTT assay, IC50 = 1 μM. 19053767
MRC5 Antiproliferative assay 96 hrs Antiproliferative activity against human MRC5 cells after 96 hrs by MTT assay, IC50 = 3.9 μM. 19053767
MT4 Antiproliferative assay 96 hrs Antiproliferative activity against human MT4 cells after 96 hrs by MTT assay, IC50 = 1.25 μM. 19053767
SF-268 Antiproliferative assay 96 hrs Antiproliferative activity against human SF-268 cells after 96 hrs by MTT assay, IC50 = 3.25 μM. 19053767
XF498 Antiproliferative assay 96 hrs Antiproliferative activity against human XF498 cells after 96 hrs by MTT assay, IC50 = 3.45 μM. 19053767
KB Growth inhibition assay 72 hrs Growth inhibition of human KB cells after 72 hrs by methylene blue dye assay, IC50 = 1.1 μM. 19053773
KB-TAX50 Growth inhibition assay 72 hrs Growth inhibition of human Pgp170 overexpressing multidrug resistant-KB-TAX50 cells after 72 hrs by methylene blue dye assay, IC50 = 3.5 μM. 19053773
KB-VIN10 Growth inhibition assay 72 hrs Growth inhibition of human Pgp170 overexpressing multidrug resistant-KB-VIN10 cells after 72 hrs by methylene blue dye assay, IC50 = 23 μM. 19053773
A549 Cytotoxicity assay 48 hrs Cytotoxicity against human A549 cells after 48 hrs by WST-8 assay, IC50 = 1.7 μM. 19072209
MCF7 Cytotoxicity assay 48 hrs Cytotoxicity against human MCF7 cells after 48 hrs by WST-8 assay, IC50 = 7.6 μM. 19072209
NB4 Cytotoxicity assay 48 hrs Cytotoxicity against human NB4 cells after 48 hrs by WST-8 assay, IC50 = 1.3 μM. 19072209
PC3 Cytotoxicity assay 48 hrs Cytotoxicity against human PC3 cells after 48 hrs by WST-8 assay, IC50 = 13.6 μM. 19072209
SH-SY5Y Cytotoxicity assay 48 hrs Cytotoxicity against human SH-SY5Y cells after 48 hrs by WST-8 assay, IC50 = 1.7 μM. 19072209
A549 Cytotoxicity assay 48 hrs Cytotoxicity against human A549 cells after 48 hrs, IC50 = 1.2 μM. 19115839
DLD1 Cytotoxicity assay 48 hrs Cytotoxicity against human DLD1 cells after 48 hrs, IC50 = 27 μM. 19115839
MCF7 Cytotoxicity assay 48 hrs Cytotoxicity against human MCF7 cells after 48 hrs, IC50 = 0.7 μM. 19115839
PC3 Cytotoxicity assay 48 hrs Cytotoxicity against human PC3 cells after 48 hrs, IC50 = 1.7 μM. 19115839
WS1 Cytotoxicity assay 48 hrs Cytotoxicity against human WS1 cells after 48 hrs, IC50 = 34 μM. 19115839
HL60 Cytotoxicity assay 48 hrs Cytotoxicity against human HL60 cells after 48 hrs by MTT assay, IC50 = 3.3 μM. 19251420
AGS Cytotoxicity assay 72 hrs Cytotoxicity against human AGS cells after 72 hrs by MTT assay, IC50 = 0.36 μM. 19269832
J82 Cytotoxicity assay 72 hrs Cytotoxicity against human J82 cells after 72 hrs by MTT assay, IC50 = 2.8 μM. 19269832
MRC5 Cytotoxicity assay 72 hrs Cytotoxicity against human MRC5 cells after 72 hrs by MTT assay, IC50 = 3.9 μM. 19269832
SKMES1 Cytotoxicity assay 72 hrs Cytotoxicity against human SKMES1 cells after 72 hrs by MTT assay, IC50 = 2.5 μM. 19269832
A549 Cytotoxicity assay 72 hrs Cytotoxicity against human A549 cells after 72 hrs by MTT assay, IC50 = 14.3 μM. 19394829
CCRF-CEM Cytotoxicity assay 72 hrs Cytotoxicity against human CCRF-CEM cells after 72 hrs by MTT assay, IC50 = 1.1 μM. 19394829
HeLa Cytotoxicity assay 72 hrs Cytotoxicity against human HeLa cells after 72 hrs by MTT assay, IC50 = 3.9 μM. 19394829
Jurkat Cytotoxicity assay 72 hrs Cytotoxicity against human Jurkat cells after 72 hrs by MTT assay, IC50 = 1.2 μM. 19394829
MCF7 Cytotoxicity assay 72 hrs Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay, IC50 = 10.9 μM. 19394829
MDA-MB-231 Cytotoxicity assay 72 hrs Cytotoxicity against human MDA-MB-231 cells after 72 hrs by MTT assay, IC50 = 21.2 μM. 19394829
AGS Cytotoxicity assay 3 days Cytotoxicity against human AGS cells after 3 days by MTT assay, IC50 = 0.36 μM. 19419803
HL60 Cytotoxicity assay 3 days Cytotoxicity against human HL60 cells after 3 days by MTT assay, IC50 = 0.8 μM. 19419803
J82 Cytotoxicity assay 3 days Cytotoxicity against human J82 cells after 3 days by MTT assay, IC50 = 2.5 μM. 19419803
MRC5 Cytotoxicity assay 3 days Cytotoxicity against human MRC5 cells after 3 days by MTT assay, IC50 = 3.93 μM. 19419803
SKMES1 Cytotoxicity assay 3 days Cytotoxicity against human SKMES1 cells after 3 days by MTT assay, IC50 = 2.8 μM. 19419803
A549 Cytotoxicity assay 48 hrs Cytotoxicity against human A549 cells after 48 hrs by SRB method, IC50 = 1.7 μM. 19425589
MCF7 Cytotoxicity assay 48 hrs Cytotoxicity against human MCF7 cells after 48 hrs by SRB method, IC50 = 7.6 μM. 19425589
NB4 Cytotoxicity assay 48 hrs Cytotoxicity against human NB4 cells after 48 hrs by SRB method, IC50 = 1.3 μM. 19425589
PC3 Cytotoxicity assay 48 hrs Cytotoxicity against human PC3 cells after 48 hrs by SRB method, IC50 = 13.6 μM. 19425589
SH-SY5Y Cytotoxicity assay 48 hrs Cytotoxicity against human SH-SY5Y cells after 48 hrs by SRB method, IC50 = 1.7 μM. 19425589
HT-29 Cytotoxicity assay 96 hrs Cytotoxicity against human HT-29 cells after 96 hrs by SRB assay, GI50 = 0.73 μM. 19572549
A549 Cytotoxicity assay 72 hrs Cytotoxicity against human A549 cells after 72 hrs by MTT assay, IC50 = 0.63 μM. 19685913
Bel7402 Cytotoxicity assay 72 hrs Cytotoxicity against human Bel7402 cells after 72 hrs by MTT assay, IC50 = 1.03 μM. 19685913
HL60 Cytotoxicity assay 24 hrs Cytotoxicity against human HL60 cells after 24 hrs by SRB assay, IC50 = 0.042 μM. 19685913
P388 Cytotoxicity assay 24 hrs Cytotoxicity against mouse P388 cells after 24 hrs by SRB assay, IC50 = 0.05 μM. 19685913
HCT116 Antiproliferative assay 3 days Antiproliferative activity against human HCT116 cells after 3 days by XTT assay, IC50 = 1.7 μM. 19691293
SW948 Antiproliferative assay 3 days Antiproliferative activity against human SW948 cells after 3 days by XTT assay, IC50 = 1.3 μM. 19691293
A549 Cytotoxicity assay 24 hrs Cytotoxicity against human A549 cells after 24 hrs by SRB assay, IC50 = 0.63 μM. 19769341
HL60 Cytotoxicity assay 72 hrs Cytotoxicity against human HL60 cells after 72 hrs by MTT assay, IC50 = 0.042 μM. 19769341
HONE1 Cytotoxicity assay 72 hrs Cytotoxicity against human HONE1 cells after 72 hrs by methylene blue dye assay, IC50 = 1.2 μM. 19785430
HT-29 Cytotoxicity assay 72 hrs Cytotoxicity against human HT-29 cells after 72 hrs by methylene blue dye assay, IC50 = 2.3 μM. 19785430
KB Cytotoxicity assay 72 hrs Cytotoxicity against human KB cells after 72 hrs by methylene blue dye assay, IC50 = 1.3 μM. 19785430
HCT116 Cytotoxicity assay 4 days Cytotoxicity against human HCT116 cells after 4 days, IC50 = 14.39 μM. 19800803
HaCaT Cytotoxicity assay 72 hrs Cytotoxicity against human HaCaT cells after 72 hrs by MTT assay, IC50 = 0.55 μM. 19919064
B16 Cytotoxicity assay 72 hrs Cytotoxicity against mouse B16 cells after 72 hrs by MTT assay, IC50 = 0.28 μM. 19919064
DU145 Cytotoxicity assay 4 days Cytotoxicity against human DU145 cells after 4 days by ELISA reader assay, IC50 = 1.3 μM. 19939682
HCT15 Cytotoxicity assay 4 days Cytotoxicity against human HCT15 cells after 4 days by ELISA reader assay, IC50 = 1.09 μM. 19939682
HeLa Cytotoxicity assay 4 days Cytotoxicity against human HeLa cells after 4 days by ELISA reader assay, IC50 = 1.29 μM. 19939682
K562 Cytotoxicity assay 4 days Cytotoxicity against human K562 cells after 4 days by ELISA reader assay, IC50 = 2.41 μM. 19939682
MCF7 Cytotoxicity assay 4 days Cytotoxicity against human MCF7 cells after 4 days by ELISA reader assay, IC50 = 1.89 μM. 19939682
DU145 Cytotoxicity assay 3 days Cytotoxicity against human DU145 cells after 3 days, IC50 = 21.07 μM. 19954977
HCT116 Cytotoxicity assay 3 days Cytotoxicity against human HCT116 cells after 3 days, IC50 = 17.92 μM. 19954977
HeLa Cytotoxicity assay 3 days Cytotoxicity against human HeLa cells after 3 days, IC50 = 8.43 μM. 19954977
MCF7 Cytotoxicity assay 3 days Cytotoxicity against human MCF7 cells after 3 days, IC50 = 18.01 μM. 19954977
MDA-MB-231 Cytotoxicity assay 3 days Cytotoxicity against human MDA-MB-231 cells after 3 days, IC50 = 16.85 μM. 19954977
K562 Cytotoxicity assay 72 hrs Cytotoxicity against human K562 cells after 72 hrs by MTS assay, IC50 = 0.42 μM. 20006518
A549 Cytotoxicity assay 48 hrs Cytotoxicity against human A549 cells after 48 hrs, IC50 = 0.29 μM. 20053564
HL60 Cytotoxicity assay 48 hrs Cytotoxicity against human HL60 cells after 48 hrs, IC50 = 0.42 μM. 20053564
RPMI8226 Cytotoxicity assay 48 hrs Cytotoxicity against human RPMI8226 cells after 48 hrs, IC50 = 0.14 μM. 20053564
A549 Cytotoxicity assay 48 hrs Cytotoxicity against human A549 cells after 48 hrs by MTT assay, IC50 = 0.83 μM. 20071056
HL60 Cytotoxicity assay 72 hrs Cytotoxicity against human HL60 cells after 72 hrs by CCK8 method, IC50 = 0.18 μM. 20071056
RPMI8226 Cytotoxicity assay 72 hrs Cytotoxicity against human RPMI8226 cells after 72 hrs by CCK8 method, IC50 = 0.7 μM. 20071056
DU145 Cytotoxicity assay 48 hrs Cytotoxicity against human DU145 cells after 48 hrs by MTT assay, IC50 = 1.63 μM. 20093033
HeLa Cytotoxicity assay 48 hrs Cytotoxicity against human HeLa cells after 48 hrs by MTT assay, IC50 = 0.47 μM. 20093033
HL60 Cytotoxicity assay 48 hrs Cytotoxicity against human HL60 cells after 48 hrs by MTT assay, IC50 = 0.97 μM. 20093033
HT-29 Cytotoxicity assay 48 hrs Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay, IC50 = 1.42 μM. 20093033
MDA-MB-231 Cytotoxicity assay 48 hrs Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay, IC50 = 2.87 μM. 20093033
KB Cytotoxicity assay 72 hrs Cytotoxicity against human KB cells after 72 hrs by MTT assay, ED50 = 0.2 μM. 20187635
KB Cytotoxicity assay 72 hrs Cytotoxicity against human KB cells after 72 hrs by MTT assay, IC50 = 0.6 μM. 20187635
KB1 Cytotoxicity assay 72 hrs Cytotoxicity against human KB1 cells after 72 hrs by MTT assay, IC50 = 34.8 μM. 20187635
KB-7d Cytotoxicity assay 72 hrs Cytotoxicity against human KB-7d cells after 72 hrs by MTT assay, ED50 = 25 μM. 20187635
KB Cytotoxicity assay 72 hrs Cytotoxicity against human vincristine-resistant KB cells after 72 hrs by MTT assay, IC50 = 28.7 μM. 20187635
NCI-H460 Cytotoxicity assay 48 hrs Cytotoxicity against human NCI-H460 cells after 48 hrs by [3H]thymidine incorporation assay, IC50 = 0.09 μM. 20210346
SKHEP1 Cytotoxicity assay 48 hrs Cytotoxicity against human SKHEP1 cells after 48 hrs by [3H]thymidine incorporation assay, IC50 = 0.062 μM. 20210346
U87MG Cytotoxicity assay 48 hrs Cytotoxicity against human U87MG cells after 48 hrs by [3H]thymidine incorporation assay, IC50 = 0.145 μM. 20210346
HepG2 Growth inhibition assay 72 hrs Growth inhibition of human HepG2 cells after 72 hrs by sulforhodamine B assay, IC50 = 4.1 μM. 20346660
DU145 Cytotoxicity assay 2 days Cytotoxicity against human DU145 cells after 2 days by automatic ELISA reader system, IC50 = 0.5 μM. 20392646
HCT15 Cytotoxicity assay 2 days Cytotoxicity against human HCT15 cells after 2 days by automatic ELISA reader system, IC50 = 1.1 μM. 20392646
HeLa Cytotoxicity assay 2 days Cytotoxicity against human HeLa cells after 2 days by automatic ELISA reader system, IC50 = 1.4 μM. 20392646
HL60 Cytotoxicity assay 2 days Cytotoxicity against human HL60 cells after 2 days by automatic ELISA reader system, IC50 = 1 μM. 20392646
MDA-MB-231 Cytotoxicity assay 2 days Cytotoxicity against human MDA-MB-231 cells after 2 days by automatic ELISA reader system, IC50 = 0.7 μM. 20392646
HM-SFME-1 Antiproliferative assay 24 hrs Antiproliferative activity against mouse r/m HM-SFME-1 cells after 24 hrs by MTT assay, IC50 = 9 μM. 20398972
SFME Antiproliferative assay 24 hrs Antiproliferative activity against mouse SFME cells after 24 hrs by MTT assay, IC50 = 0.5 μM. 20398972
HT-29 Cytotoxicity assay 48 hrs Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay, IC50 = 30.38 μM. 20405844
MDA-MB-231 Cytotoxicity assay 48 hrs Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay, IC50 = 23.22 μM. 20405844
A549 Cytotoxicity assay 48 hrs Cytotoxicity against human A549 cells after 48 hrs by resazurin reduction assay, IC50 = 16 μM. 20413315
DLD1 Cytotoxicity assay 48 hrs Cytotoxicity against human DLD1 cells after 48 hrs by resazurin reduction assay, IC50 = 10 μM. 20413315
WS1 Cytotoxicity assay 48 hrs Cytotoxicity against human WS1 cells after 48 hrs by resazurin reduction assay, IC50 = 4.3 μM. 20413315
A549 Cytotoxicity assay 72 hrs Cytotoxicity against human A549 cells after 72 hrs by SRB assay, IC50 = 0.63 μM. 20415462
HL60 Cytotoxicity assay 72 hrs Cytotoxicity against human HL60 cells after 72 hrs by MTT assay, IC50 = 0.042 μM. 20415462
HL60 Cytotoxicity assay 72 hrs Cytotoxicity against human HL60 cells after 72 hrs by MTT assay, IC50 = 0.39 μM. 20524638
HL60/MX2 Cytotoxicity assay 72 hrs Cytotoxicity against human HL60/MX2 cells after 72 hrs by MTT assay, IC50 = 11.9 μM. 20570510
HL60 Cytotoxicity assay 72 hrs Cytotoxicity against human topoisomerase 2-sensitive HL60 cells after 72 hrs by MTT assay, IC50 = 1.3 μM. 20570510
A375 Cytotoxicity assay 24 hrs Cytotoxicity activity against human A375 cells after 24 hrs by NRU assay, IC50 = 19 μM. 20570625
A375 Cytotoxicity assay 48 hrs Cytotoxicity activity against human A375 cells after 48 hrs by NRU assay, IC50 = 12 μM. 20570625
B16 Cytotoxicity assay 24 hrs Cytotoxicity activity against mouse B16 cells after 24 hrs by NRU assay, IC50 = 9 μM. 20570625
B16 Cytotoxicity assay 48 hrs Cytotoxicity activity against mouse B16 cells after 48 hrs by NRU assay, IC50 = 0.13 μM. 20570625
DU145 Cytotoxicity assay 4 days Cytotoxicity against human DU145 cells after 4 days by MTT assay, IC50 = 13.8 μM. 20619511
HCT116 Cytotoxicity assay 4 days Cytotoxicity against human HCT116 cells after 4 days by MTT assay, IC50 = 11.9 μM. 20619511
HeLa Cytotoxicity assay 4 days Cytotoxicity against human HeLa cells after 4 days by MTT assay, IC50 = 18.2 μM. 20619511
MCF7 Cytotoxicity assay 4 days Cytotoxicity against human MCF7 cells after 4 days by MTT assay, IC50 = 17.5 μM. 20619511
MDA-MB-231 Cytotoxicity assay 4 days Cytotoxicity against human MDA-MB-231 cells after 4 days by MTT assay, IC50 = 16.3 μM. 20619511
AGS Cytotoxicity assay 72 hrs Cytotoxicity against human AGS cells after 72 hrs by MTT assay, IC50 = 0.36 μM. 20828890
HL-60(TB) Cytotoxicity assay 72 hrs Cytotoxicity against human HL-60(TB) cells after 72 hrs by MTT assay, IC50 = 0.8 μM. 20828890
J82 Cytotoxicity assay 72 hrs Cytotoxicity against human J82 cells after 72 hrs by MTT assay, IC50 = 2.8 μM. 20828890
MRC5 Cytotoxicity assay 72 hrs Cytotoxicity against human MRC5 cells after 72 hrs by MTT assay, IC50 = 3.9 μM. 20828890
SKMES1 Cytotoxicity assay 72 hrs Cytotoxicity against human SKMES1 cells after 72 hrs by MTT assay, IC50 = 2.5 μM. 20828890
colon cancer cells Growth inhibition assay 72 hrs Growth inhibition of human colon cancer cells after 72 hrs by sulforhodamine B assay, GI50 = 1.3 μM. 20884089
gastric cancer cells Growth inhibition assay 72 hrs Growth inhibition of human gastric cancer cells after 72 hrs by sulforhodamine B assay, GI50 = 1.3 μM. 20884089
lung cancer cells Growth inhibition assay 72 hrs Growth inhibition of human lung cancer cells after 72 hrs by sulforhodamine B assay, GI50 = 1.3 μM. 20884089
HCT15 Antiproliferative assay 48 hrs Antiproliferative activity against human HCT15 cells after 48 hrs by sulforhodamine B assay, IC50 = 1.6 μM. 20939516
MESSA Antiproliferative assay 48 hrs Antiproliferative activity against human MESSA cells after 48 hrs by sulforhodamine B assay, IC50 = 0.3 μM. 20939516
HL60 Cytotoxicity assay 72 hrs Cytotoxicity against human HL60 cells after 72 hrs, IC50 = 0.486 μM. 20961767
HL60/MX2 Cytotoxicity assay 72 hrs Cytotoxicity against human HL60/MX2 cells after 72 hrs, IC50 = 48.5 μM. 20961767
KB Cytotoxicity assay 3 days Cytotoxicity against human KB cells after 3 days by sulforhodamine B assay, EC50 = 4.5 μM. 21028898
502713 Anticancer assay 48 hrs Anticancer activity against human 502713 cells assessed as cell viability after 48 hrs by SRB assay, IC50 = 0.1 μM. 21074444
A549 Anticancer assay 48 hrs Anticancer activity against human A549 cells assessed as cell viability after 48 hrs by SRB assay, IC50 = 3.08 μM. 21074444
DU145 Anticancer assay 48 hrs Anticancer activity against human DU145 cells assessed as cell viability after 48 hrs by SRB assay, IC50 = 3.7 μM. 21074444
HCT15 Anticancer assay 48 hrs Anticancer activity against human HCT15 cells assessed as cell viability after 48 hrs by SRB assay, IC50 = 0.9 μM. 21074444
Hep2 Anticancer assay 48 hrs Anticancer activity against human Hep2 cells assessed as cell viability after 48 hrs by SRB assay, IC50 = 0.9 μM. 21074444
IMR32 Anticancer assay 48 hrs Anticancer activity against human IMR32 cells assessed as cell viability after 48 hrs by SRB assay, IC50 = 6.3 μM. 21074444
PC3 Anticancer assay 48 hrs Anticancer activity against human PC3 cells assessed as cell viability after 48 hrs by SRB assay, IC50 = 2.6 μM. 21074444
HT-29 Cytotoxicity assay 72 hrs Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay, GI50 = 31.62 μM. 21115210
K562 Cytotoxicity assay 72 hrs Cytotoxicity against human K562 cells after 72 hrs by MTT assay, GI50 = 12.59 μM. 21115210
MCF7 Cytotoxicity assay 72 hrs Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay, GI50 = 19.95 μM. 21115210
PC3 Cytotoxicity assay 72 hrs Cytotoxicity against human PC3 cells after 72 hrs by MTT assay, GI50 = 0.63 μM. 21115210
PC3 Cytotoxicity assay 72 hrs Cytotoxicity against human PC3 cells after 72 hrs by MTT assay, TGI = 3.98 μM. 21115210
95-D Cytotoxicity assay 72 hrs Cytotoxicity against human 95-D cells after 72 hrs by MTT assay, IC50 = 0.0202 μM. 21145139
A549 Cytotoxicity assay 72 hrs Cytotoxicity against human A549 cells after 72 hrs by MTT assay, IC50 = 0.00256 μM. 21145139
KB Cytotoxicity assay 72 hrs Cytotoxicity against human KB cells after 72 hrs by MTT assay, IC50 = 0.00461 μM. 21145139
KB/VCR Cytotoxicity assay 72 hrs Cytotoxicity against human KB/VCR cells after 72 hrs by MTT assay, IC50 = 0.0834 μM. 21145139
A549 Cytotoxicity assay 3 days Cytotoxicity against human A549 cells assessed as cell growth inhibition after 3 days by MTT assay, IC50 = 21.4 μM. 21277655
HCT116 Cytotoxicity assay 3 days Cytotoxicity against human HCT116 cells assessed as cell growth inhibition after 3 days by MTT assay, IC50 = 13.5 μM. 21277655
HepG2 Cytotoxicity assay 3 days Cytotoxicity against human HepG2 cells assessed as cell growth inhibition after 3 days by MTT assay, IC50 = 4.9 μM. 21277655
HT1080 Antiproliferative assay 96 hrs Antiproliferative activity against human HT1080 cells after 96 hrs by MTT assay, IC50 = 0.75 μM. 21296467
A549 Cytotoxicity assay 48 hrs Cytotoxicity against human A549 cells after 48 hrs by MTT assay, IC50 = 11 μM. 21397370
A2780 Cytotoxicity assay 48 hrs Cytotoxicity against human A2780 cells after 48 hrs by sulforhodamine B based ELISA, GI50 = 1.3 μM. 21402478
A549 Cytotoxicity assay 48 hrs Cytotoxicity against human A549 cells after 48 hrs by sulforhodamine B based ELISA, GI50 = 3.08 μM. 21402478
COLO205 Cytotoxicity assay 48 hrs Cytotoxicity against human COLO205 cells after 48 hrs by sulforhodamine B based ELISA, GI50 = 0.13 μM. 21402478
KB Cytotoxicity assay 48 hrs Cytotoxicity against human KB cells after 48 hrs by sulforhodamine B based ELISA, GI50 = 0.3 μM. 21402478
MCF7 Cytotoxicity assay 48 hrs Cytotoxicity against human MCF7 cells after 48 hrs by sulforhodamine B based ELISA, GI50 = 2.1 μM. 21402478
DU145 Cytotoxicity assay 2 days Cytotoxicity against human DU145 cells after 2 days, IC50 = 2.19 μM. 21419530
HCT116 Cytotoxicity assay 2 days Cytotoxicity against human HCT116 cells after 2 days, IC50 = 9.5 μM. 21419530
HeLa Cytotoxicity assay 2 days Cytotoxicity against human HeLa cells after 2 days, IC50 = 2.36 μM. 21419530
HL60 Cytotoxicity assay 2 days Cytotoxicity against human HL60 cells after 2 days, IC50 = 1.28 μM. 21419530
MDA-MB-231 Cytotoxicity assay 2 days Cytotoxicity against human MDA-MB-231 cells after 2 days, IC50 = 1.23 μM. 21419530
A549 Cytotoxicity assay 48 hrs Cytotoxicity against human A549 cells after 48 hrs by sulforhodamine B assay, IC50 = 5.62 μM. 21477899
HCT15 Cytotoxicity assay 48 hrs Cytotoxicity against human HCT15 cells after 48 hrs by sulforhodamine B assay, IC50 = 7.15 μM. 21477899
Hep2 Cytotoxicity assay 48 hrs Cytotoxicity against human Hep2 cells after 48 hrs by sulforhodamine B assay, IC50 = 2.15 μM. 21477899
MCF7 Cytotoxicity assay 48 hrs Cytotoxicity against human MCF7 cells after 48 hrs by sulforhodamine B assay, IC50 = 19 μM. 21477899
PC3 Cytotoxicity assay 48 hrs Cytotoxicity against human PC3 cells after 48 hrs by sulforhodamine B assay, IC50 = 17.5 μM. 21477899
SF295 Cytotoxicity assay 48 hrs Cytotoxicity against human SF295 cells after 48 hrs by sulforhodamine B assay, IC50 = 13.5 μM. 21477899
A2780 Growth inhibition assay 48 hrs Growth inhibition of human A2780 cells after 48 hrs by sulforhodamine B assay, GI50 = 1.3 μM. 21489802
A549 Growth inhibition assay 48 hrs Growth inhibition of human A549 cells after 48 hrs by sulforhodamine B assay, GI50 = 3.08 μM. 21489802
COLO205 Growth inhibition assay 48 hrs Growth inhibition of human COLO205 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.13 μM. 21489802
DWD Growth inhibition assay 48 hrs Growth inhibition of human DWD cells after 48 hrs by sulforhodamine B assay, GI50 = 0.6 μM. 21489802
Gurav Growth inhibition assay 48 hrs Growth inhibition of human Gurav cells after 48 hrs by sulforhodamine B assay, GI50 = 0.5 μM. 21489802
HOP62 Growth inhibition assay 48 hrs Growth inhibition of human HOP62 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.8 μM. 21489802
KB Growth inhibition assay 48 hrs Growth inhibition of human KB cells after 48 hrs by sulforhodamine B assay, GI50 = 0.3 μM. 21489802
MCF7 Growth inhibition assay 48 hrs Growth inhibition of human MCF7 cells after 48 hrs by sulforhodamine B assay, GI50 = 2.1 μM. 21489802
PC3 Growth inhibition assay 48 hrs Growth inhibition of human PC3 cells after 48 hrs by sulforhodamine B assay, GI50 = 2.6 μM. 21489802
SiHa Growth inhibition assay 48 hrs Growth inhibition of human SiHa cells after 48 hrs by sulforhodamine B assay, GI50 = 3.1 μM. 21489802
ZR-75-1 Growth inhibition assay 48 hrs Growth inhibition of human ZR-75-1 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.2 μM. 21489802
HeLa Cytotoxicity assay 72 hrs Cytotoxicity against human HeLa cells after 72 hrs by MTT assay, IC50 = 4 μM. 21570846
KB Cytotoxicity assay 72 hrs Cytotoxicity against human KB cells after 72 hrs by MTT assay, IC50 = 10 μM. 21570846
DU145 Cytotoxicity assay 2 days Cytotoxicity against human DU145 cells after 2 days, IC50 = 0.5 μM. 21601964
HCT15 Cytotoxicity assay 2 days Cytotoxicity against human HCT15 cells after 2 days, IC50 = 1.1 μM. 21601964
HeLa Cytotoxicity assay 2 days Cytotoxicity against human HeLa cells after 2 days, IC50 = 1.4 μM. 21601964
HL60 Cytotoxicity assay 2 days Cytotoxicity against human HL60 cells after 2 days, IC50 = 1 μM. 21601964
MDA-MB-231 Cytotoxicity assay 2 days Cytotoxicity against human MDA-MB-231 cells after 2 days, INH = 0.7 μM. 21601964
AGS Anticancer assay 3 days Anticancer activity against human AGS cells after 3 days by MTT assay, IC50 = 0.36 μM. 21621882
J82 Anticancer assay 3 days Anticancer activity against human J82 cells after 3 days by MTT assay, IC50 = 0.8 μM. 21621882
MRC5 Anticancer assay 3 days Anticancer activity against human MRC5 cells after 3 days by MTT assay, IC50 = 3.9 μM. 21621882
SKMES1 Anticancer assay 3 days Anticancer activity against human SKMES1 cells after 3 days by MTT assay, IC50 = 2.8 μM. 21621882
Caco2 Cytotoxicity assay 72 hrs Cytotoxicity against human Caco2 cells after 72 hrs by MTS assay, IC50 = 18.6 μM. 21724394
CCD-18Co Cytotoxicity assay 72 hrs Cytotoxicity against human CCD-18Co cells after 72 hrs by MTS assay, IC50 = 44.4 μM. 21724394
HCT116 Cytotoxicity assay 72 hrs Cytotoxicity against human HCT116 cells after 72 hrs by MTS assay, IC50 = 25.5 μM. 21724394
A549 Cytotoxicity assay 48 hrs Cytotoxicity against human A549 cells after 48 hrs by MTT assay, IC50 = 14.8 μM. 21733601
SiHa Cytotoxicity assay 48 hrs Cytotoxicity against human SiHa cells after 48 hrs by MTT assay, IC50 = 30.7 μM. 21733601
A2780 Cytotoxicity assay 48 hrs Cytotoxicity against human A2780 cells after 48 hrs by sulforhodamine B assay, GI50 = 1.3 μM. 21737288
A549 Cytotoxicity assay 48 hrs Cytotoxicity against human A549 cells after 48 hrs by sulforhodamine B assay, GI50 = 3.08 μM. 21737288
COLO205 Cytotoxicity assay 48 hrs Cytotoxicity against human COLO205 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.13 μM. 21737288
DWD Cytotoxicity assay 48 hrs Cytotoxicity against human DWD cells after 48 hrs by sulforhodamine B assay, GI50 = 0.6 μM. 21737288
Gurav Cytotoxicity assay 48 hrs Cytotoxicity against human Gurav cells after 48 hrs by sulforhodamine B assay, GI50 = 0.5 μM. 21737288
HOP62 Cytotoxicity assay 48 hrs Cytotoxicity against human HOP62 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.8 μM. 21737288
MCF7 Cytotoxicity assay 48 hrs Cytotoxicity against human MCF7 cells after 48 hrs by sulforhodamine B assay, GI50 = 2.1 μM. 21737288
ZR-75-1 Cytotoxicity assay 48 hrs Cytotoxicity against human ZR-75-1 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.2 μM. 21737288
CCRF-CEM Antiproliferative assay 96 hrs Antiproliferative activity against human CCRF-CEM cells after 96 hrs by MTT assay, CC50 = 0.09 μM. 21741130
CCRF-SB Antiproliferative assay 96 hrs Antiproliferative activity against human CCRF-SB cells after 96 hrs by MTT assay, CC50 = 0.1 μM. 21741130
DU145 Antiproliferative assay 96 hrs Antiproliferative activity against human DU145 cells after 96 hrs by MTT assay, CC50 = 0.4 μM. 21741130
HepG2 Antiproliferative assay 96 hrs Antiproliferative activity against human HepG2 cells after 96 hrs by MTT assay, CC50 = 0.7 μM. 21741130
MCF7 Antiproliferative assay 96 hrs Antiproliferative activity against human MCF7 cells after 96 hrs by MTT assay, CC50 = 1 μM. 21741130
SK-MEL-28 Antiproliferative assay 96 hrs Antiproliferative activity against human SK-MEL-28 cells after 96 hrs by MTT assay, CC50 = 1.2 μM. 21741130
SKMES1 Antiproliferative assay 96 hrs Antiproliferative activity against human SKMES1 cells after 96 hrs by MTT assay, CC50 = 0.3 μM. 21741130
WIL2-NS Antiproliferative assay 96 hrs Antiproliferative activity against human WIL2-NS cells after 96 hrs by MTT assay, CC50 = 0.2 μM. 21741130
MT4 Cytotoxicity assay 96 hrs Cytotoxicity against human MT4 cells infected with HTLV-1 after 96 hrs by MTT assay, CC50 = 0.09 μM. 21741130
HeLa Cytotoxicity assay 2 days Cytotoxicity against human HeLa cells after 2 days by MTT assay, IC50 = 6.27 μM. 21821321
K562 Cytotoxicity assay 2 days Cytotoxicity against human K562 cells after 2 days by MTT assay, IC50 = 2.11 μM. 21821321
HeLa Cytotoxicity assay 24 hrs Cytotoxicity against human HeLa cells assessed as inhibition of cell viability after 24 hrs by MTT assay, IC50 = 23.33 μM. 21983445
A549 Cytotoxicity assay 48 hrs Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay, IC50 = 24.9 μM. 22041063
HeLa Cytotoxicity assay 48 hrs Cytotoxicity against human HeLa cells assessed as growth inhibition after 48 hrs by CCK-8 assay, IC50 = 2.76 μM. 22041063
HL60 Cytotoxicity assay 48 hrs Cytotoxicity against human HL60 cells assessed as growth inhibition after 48 hrs by CCK-8 assay, IC50 = 2.85 μM. 22041063
SiHa Cytotoxicity assay 48 hrs Cytotoxicity against human SiHa cells assessed as growth inhibition after 48 hrs by MTT assay, IC50 = 40.4 μM. 22041063
KB Growth inhibition assay 72 hrs Growth inhibition of human KB cells after 72 hrs by methylene blue assay, IC50 = 1.1 μM. 22060033
KB-S15 Growth inhibition assay 72 hrs Growth inhibition of human KB-S15 cells after 72 hrs by methylene blue assay, IC50 = 3.5 μM. 22060033
KB-VIN10 Growth inhibition assay 72 hrs Growth inhibition of human KB-VIN10 cells after 72 hrs by methylene blue assay, IC50 = 23 μM. 22060033
CCRF-CEM Cytotoxicity assay 72 hrs Cytotoxicity against human CCRF-CEM cells after 72 hrs by MTT assay, GI50 = 12.59 μM. 22104973
HT-29 Cytotoxicity assay 72 hrs Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay, GI50 = 31.62 μM. 22104973
MCF7 Cytotoxicity assay 72 hrs Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay, GI50 = 19.95 μM. 22104973
THP1 Cytotoxicity assay 48 hrs Cytotoxicity against human THP1 cells after 48 hrs by MTT assay, IC50 = 2.16 μM. 22115593
U937 Cytotoxicity assay 48 hrs Cytotoxicity against human U937 cells after 48 hrs by MTT assay, IC50 = 17.94 μM. 22115593
B16F10 Cytotoxicity assay 48 hrs Cytotoxicity against mouse B16F10 cells after 48 hrs by MTT assay, IC50 = 18.69 μM. 22115593
HCT116 Cytotoxicity assay 72 hrs Cytotoxicity against human HCT116 cells after 72 hrs by sulforhodamine B and MTT assay, IC50 = 0.91 μM. 22119124
K562 Cytotoxicity assay 72 hrs Cytotoxicity against human K562 cells after 72 hrs by sulforhodamine B and MTT assay, IC50 = 5.16 μM. 22119124
KB Cytotoxicity assay 72 hrs Cytotoxicity against human KB cells after 72 hrs by sulforhodamine B and MTT assay, IC50 = 0.85 μM. 22119124
MCF7 Cytotoxicity assay 72 hrs Cytotoxicity against human MCF7 cells after 72 hrs by sulforhodamine B and MTT assay, IC50 = 1.09 μM. 22119124
A375 Anticancer assay 48 hrs Anticancer activity against human A375 cells after 48 hrs by MTT assay, IC50 = 1.39 μM. 22136907
A549 Anticancer assay 48 hrs Anticancer activity against human A549 cells after 48 hrs by MTT assay, IC50 = 2.34 μM. 22136907
ACHN Anticancer assay 48 hrs Anticancer activity against human ACHN cells after 48 hrs by MTT assay, IC50 = 7.61 μM. 22136907
HT-29 Anticancer assay 48 hrs Anticancer activity against human HT-29 cells after 48 hrs by MTT assay, IC50 = 1.81 μM. 22136907
MCF7 Anticancer assay 48 hrs Anticancer activity against human MCF7 cells after 48 hrs by MTT assay, IC50 = 0.68 μM. 22136907
A549 Cytotoxicity assay 48 hrs Cytotoxicity against human A549 cells after 48 hrs by MTT assay, IC50 = 24.9 μM. 22244588
HeLa Cytotoxicity assay 48 hrs Cytotoxicity against human HeLa cells after 48 hrs by CCK-8 assay, IC50 = 40.4 μM. 22244588
HL60 Cytotoxicity assay 48 hrs Cytotoxicity against human HL60 cells after 48 hrs by CCK-8 assay, IC50 = 2.85 μM. 22244588
SiHa Cytotoxicity assay 48 hrs Cytotoxicity against human SiHa cells after 48 hrs by MTT assay, IC50 = 2.76 μM. 22244588
DU145 Cytotoxicity assay 96 hrs Cytotoxicity against human DU145 cells after 96 hrs, IC50 = 3 μM. 22276775
HepG2 Cytotoxicity assay 96 hrs Cytotoxicity against human HepG2 cells after 96 hrs, IC50 = 4 μM. 22276775
MT4 Cytotoxicity assay 96 hrs Cytotoxicity against human MT4 cells after 96 hrs, IC50 = 0.09 μM. 22276775
DU145 Cytotoxicity assay 2 days Cytotoxicity against human DU145 cells after 2 days, IC50 = 2.94 μM. 22318164
HCT15 Cytotoxicity assay 2 days Cytotoxicity against human HCT15 cells after 2 days, IC50 = 1.33 μM. 22318164
HeLa Cytotoxicity assay 2 days Cytotoxicity against human HeLa cells after 2 days, IC50 = 3.2 μM. 22318164
K562 Cytotoxicity assay 2 days Cytotoxicity against human K562 cells after 2 days, IC50 = 2.09 μM. 22318164
MCF7 Cytotoxicity assay 2 days Cytotoxicity against human MCF7 cells after 2 days, IC50 = 3.25 μM. 22318164
A549 Cytotoxicity assay 2 days Cytotoxicity against human A549 cells after 2 days by MTT assay, IC50 = 9.51 μM. 22325897
HL60 Cytotoxicity assay 2 days Cytotoxicity against human HL60 cells after 2 days by MTT assay, IC50 = 1.83 μM. 22325897
Jurkat Cytotoxicity assay 2 days Cytotoxicity against human Jurkat cells after 2 days by MTT assay, IC50 = 5.35 μM. 22325897
THP1 Cytotoxicity assay 2 days Cytotoxicity against human THP1 cells after 2 days by MTT assay, IC50 = 2.16 μM. 22325897
U937 Cytotoxicity assay 2 days Cytotoxicity against human U937 cells after 2 days by MTT assay, IC50 = 17.94 μM. 22325897
A549 Cytotoxicity assay 72 hrs Cytotoxicity against human A549 cells after 72 hrs by MTT assay, IC50 = 23.8 μM. 22342101
Hep3B Cytotoxicity assay 72 hrs Cytotoxicity against human Hep3B cells after 72 hrs by MTT assay, IC50 = 6.7 μM. 22342101
U87 Cytotoxicity assay 72 hrs Cytotoxicity against human U87 cells after 72 hrs by MTT assay, IC50 = 12.4 μM. 22342101
A2780 Growth inhibition assay 48 hrs Growth inhibition of human A2780 cells after 48 hrs by sulforhodamine B assay, GI50 = 1.31 μM. 22364746
A549 Growth inhibition assay 48 hrs Growth inhibition of human A549 cells after 48 hrs by sulforhodamine B assay, GI50 = 3.08 μM. 22364746
COLO205 Growth inhibition assay 48 hrs Growth inhibition of human COLO205 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.13 μM. 22364746
DWD Growth inhibition assay 48 hrs Growth inhibition of human DWD cells after 48 hrs by sulforhodamine B assay, GI50 = 0.62 μM. 22364746
HOP62 Growth inhibition assay 48 hrs Growth inhibition of human HOP62 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.8 μM. 22364746
KB Growth inhibition assay 48 hrs Growth inhibition of human KB cells after 48 hrs by sulforhodamine B assay, GI50 = 0.31 μM. 22364746
MCF7 Growth inhibition assay 48 hrs Growth inhibition of human MCF7 cells after 48 hrs by sulforhodamine B assay, GI50 = 2.11 μM. 22364746
ZR-75-1 Growth inhibition assay 48 hrs Growth inhibition of human ZR-75-1 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.2 μM. 22364746
Vero Cytotoxicity assay 48 hrs Cytotoxicity against african green monkey Vero cells after 48 hrs by MTT assay, LC50 = 18 μM. 22381050
HEK293 Cytotoxicity assay 48 hrs Cytotoxicity against human HEK293 cells after 48 hrs by MTT assay, LC50 = 28 μM. 22381050
DU145 Cytotoxicity assay 2 days Cytotoxicity against human DU145 cells after 2 days by cell counting kit-8 analysis, IC50 = 1.21 μM. 22503656
HCT15 Cytotoxicity assay 2 days Cytotoxicity against human HCT15 cells after 2 days by cell counting kit-8 analysis, IC50 = 1.17 μM. 22503656
HEK293 Cytotoxicity assay 2 days Cytotoxicity against human HEK293 cells after 2 days by cell counting kit-8 analysis, IC50 = 1.21 μM. 22503656
T47D Cytotoxicity assay 2 days Cytotoxicity against human T47D cells after 2 days by cell counting kit-8 analysis, IC50 = 2.39 μM. 22503656
MCF7 Cytotoxicity assay 48 hrs Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay, IC50 = 0.48 μM. 22564383
T98G Cytotoxicity assay 48 hrs Cytotoxicity against human T98G cells expressing mutant p53 after 48 hrs by MTT assay, IC50 = 0.46 μM. 22564383
U87 Cytotoxicity assay 48 hrs Cytotoxicity against human U87 cells expressing wild-type p53 after 48 hrs by MTT assay, IC50 = 0.62 μM. 22564383
COLO205 Antiproliferative assay 48 hrs Antiproliferative activity against human COLO205 cells after 48 hrs by MTT assay, IC50 = 0.43 μM. 22578452
HepG2 Antiproliferative assay 48 hrs Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay, IC50 = 4.76 μM. 22578452
THP1 Antiproliferative assay 48 hrs Antiproliferative activity against human THP1 cells after 48 hrs by MTT assay, IC50 = 2.16 μM. 22578452
U937 Antiproliferative assay 48 hrs Antiproliferative activity against human U937 cells after 48 hrs by MTT assay, IC50 = 17.96 μM. 22578452
B16F10 Antiproliferative assay 48 hrs Antiproliferative activity against mouse B16F10 cells after 48 hrs by MTT assay, IC50 = 18.71 μM. 22578452
CCRF-CEM Cytotoxicity assay 48 hrs Cytotoxicity against human CCRF-CEM cells assessed as cell viability after 48 hrs by celltiter-blue assay, IC50 = 0.24 μM. 22582991
HL60 Cytotoxicity assay 48 hrs Cytotoxicity against human HL60 cells assessed as cell viability after 48 hrs by celltiter-blue assay, IC50 = 0.11 μM. 22582991
K562 Cytotoxicity assay 48 hrs Cytotoxicity against human K562 cells assessed as cell viability after 48 hrs by celltiter-blue assay, IC50 = 2.3 μM. 22582991
HeLa Antiproliferative assay 48 hrs Antiproliferative activity against human HeLa cells after 48 hrs by SRB assay, GI50 = 3.56 μM. 22682920
HeLa Antiproliferative assay 48 hrs Antiproliferative activity against human HeLa cells after 48 hrs by SRB assay, TGI = 40.18 μM. 22682920
MCF7 Antiproliferative assay 48 hrs Antiproliferative activity against human MCF7 cells after 48 hrs by SRB assay, GI50 = 0.56 μM. 22682920
TK10 Antiproliferative assay 48 hrs Antiproliferative activity against human TK10 cells after 48 hrs by SRB assay, GI50 = 7.19 μM. 22682920
TK10 Antiproliferative assay 48 hrs Antiproliferative activity against human TK10 cells after 48 hrs by SRB assay, TGI = 49.74 μM. 22682920
UACC62 Antiproliferative assay 48 hrs Antiproliferative activity against human UACC62 cells after 48 hrs by SRB assay, GI50 = 0.89 μM. 22682920
Vero Cytotoxicity assay 72 hrs Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay, IC50 = 31.14 μM. 22687745
A549 Cytotoxicity assay 72 hrs Cytotoxicity against human A549 cells after 72 hrs by MTT assay, IC50 = 10.12 μM. 22687745
HepG2 Cytotoxicity assay 72 hrs Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay, IC50 = 5.48 μM. 22687745
SGC7901 Cytotoxicity assay 72 hrs Cytotoxicity against human SGC7901 cells after 72 hrs by MTT assay, IC50 = 12.09 μM. 22687745
SH-SY5Y Cytotoxicity assay 72 hrs Cytotoxicity against human SH-SY5Y cells after 72 hrs by MTT assay, IC50 = 5.37 μM. 22687745
L929 Cytotoxicity assay 72 hrs Cytotoxicity against mouse L929 cells after 72 hrs by MTT assay, IC50 = 1 μM. 22687745
KBCPT100 Antiproliferative assay 72 hrs Antiproliferative activity against human camptothecin-resistant KBCPT100 cells after 72 hrs by ethylene blue dye assay, IC50 = 0.336 μM. 22698783
KB Antiproliferative assay 72 hrs Antiproliferative activity against human KB cells after 72 hrs by ethylene blue dye assay, IC50 = 0.475 μM. 22698783
KBCPT100 Antiproliferative assay 72 hrs Antiproliferative activity against human partially revertant camptothecin-resistant KBCPT100 cells after 72 hrs by ethylene blue dye assay, IC50 = 0.374 μM. 22698783
DU145 Cytotoxicity assay 72 hrs Cytotoxicity against human DU145 cells after 72 hrs by MTT assay, IC50 = 1.42 μM. 22819942
HCT15 Cytotoxicity assay 72 hrs Cytotoxicity against human HCT15 cells after 72 hrs by MTT assay, IC50 = 0.28 μM. 22819942
HEK293 Cytotoxicity assay 72 hrs Cytotoxicity against human HEK293 cells after 72 hrs by MTT assay, IC50 = 0.41 μM. 22819942
T47D Cytotoxicity assay 72 hrs Cytotoxicity against human T47D cells after 72 hrs by MTT assay, IC50 = 1.21 μM. 22819942
A549 Antiproliferative assay 72 hrs Antiproliferative activity at human A549 cells after 72 hrs by MTT assay, IC50 = 0.8 μM. 22861499
DMS53 Antiproliferative assay 72 hrs Antiproliferative activity at human DMS53 cells after 72 hrs by MTT assay, IC50 = 1.5 μM. 22861499
MCF7 Cytotoxicity assay 48 hrs Cytotoxicity against human MCF7 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.83 μM. 22889556
TK10 Cytotoxicity assay 48 hrs Cytotoxicity against human TK10 cells after 48 hrs by sulforhodamine B assay, GI50 = 5.89 μM. 22889556
TK10 Cytotoxicity assay 48 hrs Cytotoxicity against human TK10 cells after 48 hrs by sulforhodamine B assay, TGI = 43.33 μM. 22889556
UACC62 Cytotoxicity assay 48 hrs Cytotoxicity against human UACC62 cells after 48 hrs by sulforhodamine B assay, GI50 = 3.41 μM. 22889556
UACC62 Cytotoxicity assay 48 hrs Cytotoxicity against human UACC62 cells after 48 hrs by sulforhodamine B assay, TGI = 4 μM. 22889556
DOGUM Cytotoxicity assay 72 hrs Cytotoxicity against human DOGUM cells after 72 hrs by MTT assay, IC50 = 0.075 μM. 23031590
DOGUM Cytotoxicity assay 72 hrs Cytotoxicity against human etoposide-resistant DOGUM cells after 72 hrs by MTT assay, IC50 = 0.28 μM. 23031590
GUMBUS Cytotoxicity assay 72 hrs Cytotoxicity against human etoposide-resistant GUMBUS cells after 72 hrs by MTT assay, IC50 = 0.57 μM. 23031590
GUMBUS Cytotoxicity assay 72 hrs Cytotoxicity against human GUMBUS cells after 72 hrs by MTT assay, IC50 = 0.042 μM. 23031590
A549 Growth inhibition assay 72 hrs Growth inhibition of human A549 cells after 72 hrs by SRB assay, GI50 = 2.2 μM. 23153810
HT-29 Growth inhibition assay 72 hrs Growth inhibition of human HT-29 cells after 72 hrs by SRB assay, GI50 = 9.4 μM. 23153810
MDA-MB-231 Growth inhibition assay 72 hrs Growth inhibition of human MDA-MB-231 cells after 72 hrs by SRB assay, GI50 = 7.2 μM. 23153810
A549 Cytotoxicity assay 72 hrs Cytotoxicity against human A549 cells after 72 hrs by MTT assay, IC50 = 2.8 μM. 23182091
ACHN Cytotoxicity assay 72 hrs Cytotoxicity against human ACHN cells after 72 hrs by MTT assay, IC50 = 7.61 μM. 23182091
HeLa Cytotoxicity assay 72 hrs Cytotoxicity against human HeLa cells after 72 hrs by MTT assay, IC50 = 1.52 μM. 23182091
HT-29 Cytotoxicity assay 72 hrs Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay, IC50 = 1.81 μM. 23182091
B16 Cytotoxicity assay 72 hrs Cytotoxicity against mouse B16 cells after 72 hrs by MTT assay, IC50 = 1.39 μM. 23182091
HeLa Antitumor assay 48 hrs Antitumor activity against human HeLa cells assessed as growth inhibition measured after 48 hrs by MTT assay, IC50 = 8.32 μM. 23313635
HepG2 Antitumor assay 48 hrs Antitumor activity against human HepG2 cells assessed as growth inhibition measured after 48 hrs by MTT assay, IC50 = 9.14 μM. 23313635
Vero Cytotoxicity assay 48 hrs Cytotoxicity against african green monkey Vero cells after 48 hrs by MTT assay, LC50 = 29 μM. 23321564
HEK293 Cytotoxicity assay 48 hrs Cytotoxicity against HEK293 cells after 48 hrs by MTT assay, LC50 = 17 μM. 23321564
BGC832 Cytotoxicity assay 24 hrs Cytotoxicity against human BGC832 cells after 24 hrs by MTT assay, IC50 = 26.85 μM. 23369687
HeLa Cytotoxicity assay 24 hrs Cytotoxicity against human HeLa cells after 24 hrs by MTT assay, IC50 = 17.68 μM. 23369687
K562 Cytotoxicity assay 24 hrs Cytotoxicity against human K562 cells after 24 hrs by MTT assay, IC50 = 2.85 μM. 23369687
AGS Cytotoxicity assay 72 hrs Cytotoxicity against human AGS cells assessed as cell viability after 72 hrs by MTT assay, IC50 = 0.36 μM. 23454511
HL60 Cytotoxicity assay 72 hrs Cytotoxicity against human HL60 cells assessed as cell viability after 72 hrs by MTT assay, IC50 = 1.8 μM. 23454511
J82 Cytotoxicity assay 72 hrs Cytotoxicity against human J82 cells assessed as cell viability after 72 hrs by MTT assay, IC50 = 2.8 μM. 23454511
MRC5 Cytotoxicity assay 72 hrs Cytotoxicity against human MRC5 cells assessed as cell viability after 72 hrs by MTT assay, IC50 = 3.9 μM. 23454511
SKMES1 Cytotoxicity assay 72 hrs Cytotoxicity against human SKMES1 cells assessed as cell viability after 72 hrs by MTT assay, IC50 = 2.5 μM. 23454511
A549 Cytotoxicity assay 72 hrs Cytotoxicity against human A549 cells after 72 hrs by SRB assay, IC50 = 2.58 μM. 23490151
DU145 Cytotoxicity assay 72 hrs Cytotoxicity against human DU145 cells after 72 hrs by SRB assay, IC50 = 2.03 μM. 23490151
KB Cytotoxicity assay 72 hrs Cytotoxicity against human KB cells after 72 hrs by SRB assay, IC50 = 3.88 μM. 23490151
HepG2 Cytotoxicity assay 48 hrs Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay, IC50 = 6.41 μM. 23668986
A549 Cytotoxicity assay 48 hrs Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay, IC50 = 3.2 μM. 23711769
HCT8 Cytotoxicity assay 48 hrs Cytotoxicity against human HCT8 cells assessed as growth inhibition after 48 hrs by MTT assay, IC50 = 7.06 μM. 23711769
HeLa Cytotoxicity assay 48 hrs Cytotoxicity against human HeLa cells assessed as growth inhibition after 48 hrs by MTT assay, IC50 = 2.91 μM. 23711769
HL60 Cytotoxicity assay 48 hrs Cytotoxicity against human HL60 cells assessed as growth inhibition after 48 hrs by CCK-8 assay, IC50 = 1.15 μM. 23711769
HT-29 Cytotoxicity assay 72 hrs Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay, GI50 = 31.62 μM. 23831811
MCF7 Cytotoxicity assay 72 hrs Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay, GI50 = 19.95 μM. 23831811
A2780 Growth inhibition assay 48 hrs Growth inhibition of human A2780 cells after 48 hrs by sulforhodamine B assay, GI50 = 1.31 μM. 23849207
A549 Growth inhibition assay 48 hrs Growth inhibition of human A549 cells after 48 hrs by sulforhodamine B assay, GI50 = 3.08 μM. 23849207
COLO205 Growth inhibition assay 48 hrs Growth inhibition of human COLO205 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.13 μM. 23849207
DWD Growth inhibition assay 48 hrs Growth inhibition of human DWD cells after 48 hrs by sulforhodamine B assay, GI50 = 0.62 μM. 23849207
Gurav Growth inhibition assay 48 hrs Growth inhibition of human Gurav cells after 48 hrs by sulforhodamine B assay, GI50 = 0.51 μM. 23849207
HOP62 Growth inhibition assay 48 hrs Growth inhibition of human HOP62 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.8 μM. 23849207
KB Growth inhibition assay 48 hrs Growth inhibition of human KB cells after 48 hrs by sulforhodamine B assay, GI50 = 0.31 μM. 23849207
MCF7 Growth inhibition assay 48 hrs Growth inhibition of human MCF7 cells after 48 hrs by sulforhodamine B assay, GI50 = 2.11 μM. 23849207
SiHa Growth inhibition assay 48 hrs Growth inhibition of human SiHa cells after 48 hrs by sulforhodamine B assay, GI50 = 3.11 μM. 23849207
ZR-75-1 Growth inhibition assay 48 hrs Growth inhibition of human ZR-75-1 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.2 μM. 23849207
HL60 Cytotoxicity assay 72 hrs Cytotoxicity against human HL60 cells after 72 hrs by MTT assay, IC50 = 0.5 μM. 23865778
U937 Cytotoxicity assay 72 hrs Cytotoxicity against human U937 cells after 72 hrs by MTT assay, IC50 = 1.4 μM. 23865778
H460 Cytotoxicity assay 48 hrs Cytotoxicity against human H460 cells after 48 hrs by MTT assay, IC50 = 1 μM. 23867385
HL60 Cytotoxicity assay 48 hrs Cytotoxicity against human HL60 cells after 48 hrs by MTT assay, IC50 = 5.48 μM. 23867385
A549 Cytotoxicity assay 48 hrs Cytotoxicity against human A549 cells after 48 hrs by MTT assay, IC50 = 32.05 μM. 23968711
HL60 Cytotoxicity assay 48 hrs Cytotoxicity against human HL60 cells after 48 hrs by MTT assay, IC50 = 0.33 μM. 23968711
K562 Cytotoxicity assay 48 hrs Cytotoxicity against human K562 cells after 48 hrs by MTT assay, IC50 = 8.45 μM. 23968711
MCF10A Cytotoxicity assay 72 hrs Cytotoxicity against human MCF10A cells after 72 hrs by MTT assay, IC50 = 36.26 μM. 23999041
MCF7 Cytotoxicity assay 48 hrs Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay, GI50 = 0.87 μM. 23999041
MCF7 Cytotoxicity assay 72 hrs Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay, IC50 = 1.2 μM. 23999041
MDA-MB-231 Cytotoxicity assay 48 hrs Cytotoxicity against human MDA-MB-231 cells after 48 hrs by SRB assay, GI50 = 1.67 μM. 23999041
MDA-MB-231 Cytotoxicity assay 72 hrs Cytotoxicity against human MDA-MB-231 cells after 72 hrs by MTT assay, IC50 = 1.5 μM. 23999041
A549 Antiproliferative assay 72 hrs Antiproliferative activity against human A549 cells assessed as cell viability after 72 hrs by MTT assay, IC50 = 14.3 μM. 24012378
CCRF-CEM Antiproliferative assay 72 hrs Antiproliferative activity against human CCRF-CEM cells assessed as cell viability after 72 hrs by MTT assay, IC50 = 1.1 μM. 24012378
HeLa Antiproliferative assay 72 hrs Antiproliferative activity against human HeLa cells assessed as cell viability after 72 hrs by MTT assay, IC50 = 3.9 μM. 24012378
Jurkat Antiproliferative assay 72 hrs Antiproliferative activity against human Jurkat cells assessed as cell viability after 72 hrs by MTT assay, IC50 = 1.2 μM. 24012378
MCF7 Antiproliferative assay 72 hrs Antiproliferative activity against human MCF7 cells assessed as cell viability after 72 hrs by MTT assay, IC50 = 10.9 μM. 24012378
MDA-MB-231 Antiproliferative assay 72 hrs Antiproliferative activity against human MDA-MB-231 cells assessed as cell viability after 72 hrs by MTT assay, IC50 = 21.2 μM. 24012378
HEK293 Cytotoxicity assay 2 days Cytotoxicity against HEK293 cells after 2 days by CCK-8 assay, IC50 = 0.72 μM. 24013413
DU145 Cytotoxicity assay 2 days Cytotoxicity against human DU145 cells after 2 days by CCK-8 assay, IC50 = 9.29 μM. 24013413
HCT15 Cytotoxicity assay 2 days Cytotoxicity against human HCT15 cells after 2 days by CCK-8 assay, IC50 = 5.12 μM. 24013413
T47D Cytotoxicity assay 2 days Cytotoxicity against human T47D cells after 2 days by CCK-8 assay, IC50 = 3.42 μM. 24013413
A549 Antiproliferative assay 72 hrs Antiproliferative activity against human A549 cells assessed as cell viability after 72 hrs by MTT assay, IC50 = 1.71 μM. 24095018
HCT116 Antiproliferative assay 72 hrs Antiproliferative activity against human HCT116 cells assessed as cell viability after 72 hrs by MTT assay, IC50 = 0.87 μM. 24095018
A549 Cytotoxicity assay 48 hrs Cytotoxicity against human A549 cells after 48 hrs by MTT assay, IC50 = 14.9 μM. 24095019
HCT8 Cytotoxicity assay 48 hrs Cytotoxicity against human HCT8 cells after 48 hrs by MTT assay, IC50 = 6.54 μM. 24095019
HeLa Cytotoxicity assay 48 hrs Cytotoxicity against human HeLa cells after 48 hrs by MTT assay, IC50 = 4.73 μM. 24095019
HepG2 Cytotoxicity assay 48 hrs Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay, IC50 = 11.52 μM. 24095019
KB Cytotoxicity assay 72 hrs Cytotoxicity against human KB cells assessed as growth inhibition after 72 hrs by methylene blue staining-based assay, IC50 = 1.1 μM. 24106982
KB-S15 Cytotoxicity assay 72 hrs Cytotoxicity against human KB-S15 cells overexpressing P-gp170/MDR assessed as growth inhibition after 72 hrs by methylene blue staining-based assay, IC50 = 3.5 μM. 24106982
KB-VIN10 Cytotoxicity assay 72 hrs Cytotoxicity against human KB-VIN10 cells overexpressing P-gp170/MDR assessed as growth inhibition after 72 hrs by methylene blue staining-based assay, IC50 = 23 μM. 24106982
A549 Cytotoxicity assay 48 hrs Cytotoxicity against human A549 cells after 48 hrs by MTT assay, IC50 = 3.2 μM. 24140948
HCT8 Cytotoxicity assay 48 hrs Cytotoxicity against human HCT8 cells after 48 hrs by MTT assay, IC50 = 7.06 μM. 24140948
HeLa Cytotoxicity assay 48 hrs Cytotoxicity against human HeLa cells after 48 hrs by MTT assay, IC50 = 2.91 μM. 24140948
HL60 Cytotoxicity assay 48 hrs Cytotoxicity against human HL60 cells after 48 hrs by cell counting kit-8 assay, IC50 = 1.15 μM. 24140948
A549 Growth inhibition assay 72 hrs Growth inhibition of human A549 cells after 72 hrs by MTT assay, IC50 = 2 μM. 24180210
Hs683 Growth inhibition assay 72 hrs Growth inhibition of human Hs683 cells after 72 hrs by MTT assay, IC50 = 2 μM. 24180210
MCF7 Growth inhibition assay 72 hrs Growth inhibition of human MCF7 cells after 72 hrs by MTT assay, IC50 = 4 μM. 24180210
SK-MEL-28 Growth inhibition assay 72 hrs Growth inhibition of human SK-MEL-28 cells after 72 hrs by MTT assay, IC50 = 3 μM. 24180210
U373 Growth inhibition assay 72 hrs Growth inhibition of human U373 cells after 72 hrs by MTT assay, IC50 = 25 μM. 24180210
HBL100 Growth inhibition assay 48 hrs Growth inhibition of human HBL100 cells after 48 hrs by SRB assay, GI50 = 1.4 μM. 24211632
HeLa Growth inhibition assay 48 hrs Growth inhibition of human HeLa cells after 48 hrs by SRB assay, GI50 = 3.3 μM. 24211632
SW1573 Growth inhibition assay 48 hrs Growth inhibition of human SW1573 cells after 48 hrs by SRB assay, GI50 = 15 μM. 24211632
T47D Growth inhibition assay 48 hrs Growth inhibition of human T47D cells after 48 hrs by SRB assay, GI50 = 22 μM. 24211632
WiDr Growth inhibition assay 48 hrs Growth inhibition of human WiDr cells after 48 hrs by SRB assay, GI50 = 23 μM. 24211632
HCT116 Antiproliferative assay 72 hrs Antiproliferative activity against human HCT116 cells assessed as cell viability after 72 hrs by MTS assay, IC50 = 1 μM. 24328269
A549 Cytotoxicity assay 72 hrs Cytotoxicity against human A549 cells after 72 hrs by sulforhodamine B assay, IC50 = 2.58 μM. 24332656
DU145 Cytotoxicity assay 72 hrs Cytotoxicity against human DU145 cells after 72 hrs by sulforhodamine B assay, IC50 = 2.03 μM. 24332656
KB Cytotoxicity assay 72 hrs Cytotoxicity against human KB cells after 72 hrs by sulforhodamine B assay, IC50 = 3.88 μM. 24332656
A549 Cytotoxicity assay 72 hrs Cytotoxicity against human A549 cells after 72 hrs by MTT assay relative to untreated control, GI50 = 4.46 μM. 24389510
HT-29 Cytotoxicity assay 72 hrs Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay relative to untreated control, GI50 = 31.62 μM. 24389510
MCF7 Cytotoxicity assay 72 hrs Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay relative to untreated control, GI50 = 19.95 μM. 24389510
PC3 Cytotoxicity assay 72 hrs Cytotoxicity against human PC3 cells after 72 hrs by MTT assay relative to untreated control, GI50 = 0.63 μM. 24389510
PC3 Cytotoxicity assay 72 hrs Cytotoxicity against human PC3 cells after 72 hrs by MTT assay relative to untreated control, TGI = 3.98 μM. 24389510
RWPE1 Cytotoxicity assay 72 hrs Cytotoxicity against human RWPE1 cells after 72 hrs by MTT assay relative to untreated control, GI50 = 0.9 μM. 24389510
RWPE1 Cytotoxicity assay 72 hrs Cytotoxicity against human RWPE1 cells after 72 hrs by MTT assay relative to untreated control, TGI = 4.8 μM. 24389510
HeLa Cytotoxicity assay 48 hrs Cytotoxicity against human HeLa cells after 48 hrs by MTT assay, IC50 = 4.71 μM. 24487188
HT-29 Cytotoxicity assay 48 hrs Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay, IC50 = 21.45 μM. 24487188
MCF7 Cytotoxicity assay 48 hrs Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay, IC50 = 23.9 μM. 24487188
MDA-MB-231 Cytotoxicity assay 48 hrs Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay, IC50 = 24.22 μM. 24487188
ME180 Cytotoxicity assay 48 hrs Cytotoxicity against human ME180 cells after 48 hrs by MTT assay, IC50 = 8.9 μM. 24487188
PC3 Cytotoxicity assay 48 hrs Cytotoxicity against human PC3 cells after 48 hrs by MTT assay, IC50 = 14.4 μM. 24487188
DLD1 Growth inhibition assay 72 hrs Growth inhibition of human DLD1 cells assessed as inhibition of cell viability after 72 hrs by MTT assay, IC50 = 20 μM. 24527835
HeLa Growth inhibition assay 72 hrs Growth inhibition of human HeLa cells assessed as inhibition of cell viability after 72 hrs by MTT assay, IC50 = 16 μM. 24527835
A549 Cytotoxicity assay 72 hrs Cytotoxicity against human A549 cells after 72 hrs by SRB assay, IC50 = 2.58 μM. 24553146
DU145 Cytotoxicity assay 72 hrs Cytotoxicity against human DU145 cells after 72 hrs by SRB assay, IC50 = 2.03 μM. 24553146
KB Cytotoxicity assay 72 hrs Cytotoxicity against human KB cells after 72 hrs by SRB assay, IC50 = 3.88 μM. 24553146
KB Cytotoxicity assay 72 hrs Cytotoxicity against human KB cells after 72 hrs by methylene blue assay, IC50 = 1.5 μM. 24657567
KB-S15 Cytotoxicity assay 72 hrs Cytotoxicity against human vincristine/paclitaxel-resistant KB-S15 cells overexpressing P-gp170 after 72 hrs by methylene blue assay, IC50 = 3.5 μM. 24657567
KB-VIN10 Cytotoxicity assay 72 hrs Cytotoxicity against human vincristine/paclitaxel-resistant KB-VIN10 cells overexpressing P-gp170 after 72 hrs by methylene blue assay, IC50 = 26.4 μM. 24657567
KB-7d Cytotoxicity assay 72 hrs Cytotoxicity against human VP16-resistant KB-7d cells overexpressing MRP after 72 hrs by methylene blue assay, IC50 = 46.1 μM. 24657567
A549 Anticancer assay 48 hrs Anticancer activity against human A549 cells after 48 hrs by MTT assay, IC50 = 2.45 μM. 24721832
ACHN Anticancer assay 48 hrs Anticancer activity against human ACHN cells after 48 hrs by MTT assay, IC50 = 2.04 μM. 24721832
DU145 Anticancer assay 48 hrs Anticancer activity against human DU145 cells after 48 hrs by MTT assay, IC50 = 3.17 μM. 24721832
HeLa Anticancer assay 48 hrs Anticancer activity against human HeLa cells after 48 hrs by MTT assay, IC50 = 2.75 μM. 24721832
HT-29 Anticancer assay 48 hrs Anticancer activity against human HT-29 cells after 48 hrs by MTT assay, IC50 = 1.47 μM. 24721832
BGC823 Cytotoxicity assay 48 hrs Cytotoxicity against human BGC823 cells after 48 hrs by MTT assay, IC50 = 30.74 μM. 24775914
HepG2 Cytotoxicity assay 48 hrs Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay, IC50 = 15.32 μM. 24775914
HL-7702 Cytotoxicity assay 48 hrs Cytotoxicity against human HL-7702 cells after 48 hrs by MTT assay, IC50 = 24.61 μM. 24775914
H460 Antiproliferative assay 72 hrs Antiproliferative activity against human H460 cells after 72 hrs by MTT assay, IC50 = 0.1 μM. 24780599
HCT116 Antiproliferative assay 72 hrs Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay, IC50 = 5 μM. 24780599
MCF7 Antiproliferative assay 72 hrs Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay, IC50 = 1 μM. 24780599
HepG2 Cytotoxicity assay 48 hrs Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay, IC50 = 30.16 μM. 24836071
MOLT3 Cytotoxicity assay 48 hrs Cytotoxicity against human MOLT3 cells after 48 hrs by MTT assay, IC50 = 0.051 μM. 24836071
EPG85-257P Antiproliferative assay 5 days Antiproliferative activity against human EPG85-257P cells after 5 days by sulforhodamine B assay, IC50 = 0.105 μM. 24864039
EPG85-257RD Antiproliferative assay 5 days Antiproliferative activity against human EPG85-257RD cells after 5 days by sulforhodamine B assay, IC50 = 6.2 μM. 24864039
EPG85-257RN Antiproliferative assay 5 days Antiproliferative activity against human EPG85-257RN cells after 5 days by sulforhodamine B assay, IC50 = 1.55 μM. 24864039
EPP85-181P Antiproliferative assay 5 days Antiproliferative activity against human EPP85-181P cells after 5 days by sulforhodamine B assay, IC50 = 0.58 μM. 24864039
EPP85-181RN Antiproliferative assay 5 days Antiproliferative activity against human EPP85-181RN cells after 5 days by sulforhodamine B assay, IC50 = 4.5 μM. 24864039
HT-29 Antiproliferative assay 5 days Antiproliferative activity against human HT-29 cells after 5 days by sulforhodamine B assay, IC50 = 2.3 μM. 24864039
HT-29RD Antiproliferative assay 5 days Antiproliferative activity against human HT-29RD cells after 5 days by sulforhodamine B assay, IC50 = 26 μM. 24864039
HT-29RN Antiproliferative assay 5 days Antiproliferative activity against human HT-29RN cells after 5 days by sulforhodamine B assay, IC50 = 35 μM. 24864039
DU145 Cytotoxicity assay 2 days Cytotoxicity against human DU145 cells after 2 days, IC50 = 13.85 μM. 24904965
HCT15 Cytotoxicity assay 2 days Cytotoxicity against human HCT15 cells after 2 days, IC50 = 9.45 μM. 24904965
MCF10A Cytotoxicity assay 2 days Cytotoxicity against human MCF10A cells after 2 days, IC50 = 12.23 μM. 24904965
T47D Cytotoxicity assay 2 days Cytotoxicity against human T47D cells after 2 days, IC50 = 2.57 μM. 24904965
A549 Growth inhibition assay 72 hrs Growth inhibition of human A549 cells after 72 hrs by MTT assay, IC50 = 0.1 μM. 24950030
Hs683 Growth inhibition assay 72 hrs Growth inhibition of human Hs683 cells after 72 hrs by MTT assay, IC50 = 1 μM. 24950030
MCF7 Growth inhibition assay 72 hrs Growth inhibition of human MCF7 cells after 72 hrs by MTT assay, IC50 = 17 μM. 24950030
PC3 Growth inhibition assay 72 hrs Growth inhibition of human PC3 cells after 72 hrs by MTT assay, IC50 = 2 μM. 24950030
SK-MEL-28 Growth inhibition assay 72 hrs Growth inhibition of human SK-MEL-28 cells after 72 hrs by MTT assay, IC50 = 1 μM. 24950030
U373 Growth inhibition assay 72 hrs Growth inhibition of human U373 cells after 72 hrs by MTT assay, IC50 = 7 μM. 24950030
HL60 Cytotoxicity assay 72 hrs Cytotoxicity against human HL60 cells after 72 hrs by MTT assay, IC50 = 0.6 μM. 25014747
HepG2 Cytotoxicity assay 48 hrs Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay, IC50 = 20.389 μM. 25019480
MOLT3 Cytotoxicity assay 48 hrs Cytotoxicity against human MOLT3 cells after 48 hrs by MTT assay, IC50 = 0.051 μM. 25019480
HEK293 Cytotoxicity assay 4 days Cytotoxicity against HEK293 cells after 4 days by CCK-8 assay, IC50 = 1.04 μM. 25062006
DU145 Cytotoxicity assay 4 days Cytotoxicity against human DU145 cells after 4 days by CCK-8 assay, IC50 = 0.001 μM. 25062006
HCT15 Cytotoxicity assay 4 days Cytotoxicity against human HCT15 cells after 4 days by CCK-8 assay, IC50 = 7.74 μM. 25062006
T47D Cytotoxicity assay 4 days Cytotoxicity against human T47D cells after 4 days by CCK-8 assay, IC50 = 8.74 μM. 25062006
Vero Cytotoxicity assay 48 hrs Cytotoxicity against african green monkey Vero cells after 48 hrs by MTT assay, LC50 = 28 μM. 25078313
HEK293 Cytotoxicity assay 48 hrs Cytotoxicity against HEK293 cells after 48 hrs by MTT assay, LC50 = 18 μM. 25078313
HeLa Cytotoxicity assay 48 hrs Cytotoxicity against human HeLa cells after 48 hrs by MTT assay, IC50 = 6.27 μM. 25113878
K562 Cytotoxicity assay 48 hrs Cytotoxicity against human K562 cells after 48 hrs by MTT assay, IC50 = 3.39 μM. 25113878
HeLa Antiproliferative assay 48 hrs Antiproliferative activity against human HeLa cells assessed as growth inhibition after 48 hrs by SRB assay, GI50 = 0.62 μM. 25131956
MCF7 Antiproliferative assay 48 hrs Antiproliferative activity against human MCF7 cells assessed as growth inhibition after 48 hrs by SRB assay, GI50 = 0.25 μM. 25131956
MIAPaCa2 Antiproliferative assay 48 hrs Antiproliferative activity against human MIAPaCa2 cells assessed as growth inhibition after 48 hrs by SRB assay, GI50 = 1.1 μM. 25131956
A549 Cytotoxicity assay 72 hrs Cytotoxicity against human A549 cells after 72 hrs by sulforhodamine B assay, IC50 = 13.78 μM. 25240702
HeLa Cytotoxicity assay 72 hrs Cytotoxicity against human HeLa cells after 72 hrs by sulforhodamine B assay, IC50 = 4.36 μM. 25240702
MDA-MB-231 Cytotoxicity assay 72 hrs Cytotoxicity against human MDA-MB-231 cells after 72 hrs by sulforhodamine B assay, IC50 = 3.67 μM. 25240702
A549 Cytotoxicity assay 72 hrs Cytotoxicity against human A549 cells after 72 hrs by MTT assay, IC50 = 9.3 μM. 25402632
HCT15 Cytotoxicity assay 72 hrs Cytotoxicity against human HCT15 cells after 72 hrs by MTT assay, IC50 = 4.6 μM. 25402632
HeLa Cytotoxicity assay 72 hrs Cytotoxicity against human HeLa cells after 72 hrs by MTT assay, IC50 = 3.4 μM. 25402632
HepG2 Cytotoxicity assay 72 hrs Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay, IC50 = 3.6 μM. 25402632
U373 Cytotoxicity assay 72 hrs Cytotoxicity against human U373 cells after 72 hrs by MTT assay, IC50 = 8.5 μM. 25402632
ZR-7530 Cytotoxicity assay 72 hrs Cytotoxicity against human ZR-7530 cells after 72 hrs by MTT assay, IC50 = 2.5 μM. 25402632
HeLa Cytotoxicity assay 72 hrs Cytotoxicity against human HeLa cells after 72 hrs by MTT assay, IC50 = 4.71 μM. 25453799
MCF7 Cytotoxicity assay 72 hrs Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay, IC50 = 23.9 μM. 25453799
ME180 Cytotoxicity assay 72 hrs Cytotoxicity against human ME180 cells after 72 hrs by MTT assay, IC50 = 8.9 μM. 25453799
PC3 Cytotoxicity assay 72 hrs Cytotoxicity against human PC3 cells after 72 hrs by MTT assay, IC50 = 14.4 μM. 25453799
A549 Cytotoxicity assay 48 hrs Cytotoxicity against human A549 cells after 48 hrs by MTT assay, IC50 = 10.12 μM. 25462233
HepG2 Cytotoxicity assay 48 hrs Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay, IC50 = 5.48 μM. 25462233
A549 Cytotoxicity assay 48 hrs Cytotoxicity against human A549 cells after 48 hrs by Alamar Blue assay, IC50 = 2.87 μM. 25466187
L6 Cytotoxicity assay 71.5 hrs Cytotoxicity against rat L6 cells after 71.5 hrs by Presto Blue assay, IC50 = 18.99 μM. 25466187
DU145 Cytotoxicity assay 2 days Cytotoxicity against human DU145 cells after 2 days by CCK-8 assay, IC50 = 0.5 μM. 25481396
HCT15 Cytotoxicity assay 2 days Cytotoxicity against human HCT15 cells after 2 days by CCK-8 assay, IC50 = 1.1 μM. 25481396
HeLa Cytotoxicity assay 2 days Cytotoxicity against human HeLa cells after 2 days by CCK-8 assay, IC50 = 1.26 μM. 25481396
MCF7 Cytotoxicity assay 2 days Cytotoxicity against human MCF7 cells after 2 days by CCK-8 assay, IC50 = 0.73 μM. 25481396
A549 Cytotoxicity assay 72 hrs Cytotoxicity against human A549 cells after 72 hrs by sulforhodamine B assay, IC50 = 0.8 μM. 25495422
HCT116 Cytotoxicity assay 72 hrs Cytotoxicity against human HCT116 cells after 72 hrs by sulforhodamine B assay, IC50 = 1.9 μM. 25495422
K562 Cytotoxicity assay 72 hrs Cytotoxicity against human K562 cells after 72 hrs by sulforhodamine B assay, IC50 = 3.1 μM. 25495422
MDA-MB-231 Cytotoxicity assay 72 hrs Cytotoxicity against human MDA-MB-231 cells after 72 hrs by sulforhodamine B assay, IC50 = 10.6 μM. 25495422
SKHEP1 Cytotoxicity assay 72 hrs Cytotoxicity against human SKHEP1 cells after 72 hrs by sulforhodamine B assay, IC50 = 1.1 μM. 25495422
SNU638 Cytotoxicity assay 72 hrs Cytotoxicity against human SNU638 cells after 72 hrs by sulforhodamine B assay, IC50 = 0.5 μM. 25495422
A549 Cytotoxicity assay 48 hrs Cytotoxicity against human A549 cells after 48 hrs by MTT assay, IC50 = 8.91 μM. 25599951
HeLa Cytotoxicity assay 48 hrs Cytotoxicity against human HeLa cells after 48 hrs by MTT assay, IC50 = 0.54 μM. 25599951
HL60 Cytotoxicity assay 48 hrs Cytotoxicity against human HL60 cells after 48 hrs by MTT assay, IC50 = 0.06 μM. 25599951
K562 Cytotoxicity assay 48 hrs Cytotoxicity against human K562 cells after 48 hrs by MTT assay, IC50 = 1.64 μM. 25599951
A549 Anticancer assay 48 hrs Anticancer activity against human A549 cells after 48 hrs by MTT assay, IC50 = 3.01 μM. 25615796
DU145 Anticancer assay 48 hrs Anticancer activity against human DU145 cells after 48 hrs by MTT assay, IC50 = 1.98 μM. 25615796
HeLa Anticancer assay 48 hrs Anticancer activity against human HeLa cells after 48 hrs by MTT assay, IC50 = 3.23 μM. 25615796
HepG2 Anticancer assay 48 hrs Anticancer activity against human HepG2 cells after 48 hrs by MTT assay, IC50 = 2.45 μM. 25615796
MCF7 Anticancer assay 48 hrs Anticancer activity against human MCF7 cells after 48 hrs by MTT assay, IC50 = 2.69 μM. 25615796
HepG2 Cytotoxicity assay 72 hrs Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by MTT colorimetric assay, IC50 = 1.4 μM. 25644672
MDA-MB-468 Cytotoxicity assay 72 hrs Cytotoxicity against human MDA-MB-468 cells assessed as reduction in cell viability after 72 hrs by MTT colorimetric assay, IC50 = 6.69 μM. 25644672
THP1 Cytotoxicity assay 72 hrs Cytotoxicity against human THP1 cells assessed as reduction in cell viability after 72 hrs by MTT colorimetric assay, IC50 = 1.82 μM. 25644672
U937 Cytotoxicity assay 72 hrs Cytotoxicity against human U937 cells assessed as reduction in cell viability after 72 hrs by MTT colorimetric assay, IC50 = 1.1 μM. 25644672
EL4 Cytotoxicity assay 72 hrs Cytotoxicity against mouse EL4 cells assessed as reduction in cell viability after 72 hrs by MTT colorimetric assay, IC50 = 4.9 μM. 25644672
N9 Cytotoxicity assay 72 hrs Cytotoxicity against mouse N9 cells assessed as reduction in cell viability after 72 hrs by MTT colorimetric assay, IC50 = 1.95 μM. 25644672
RAW264.7 Cytotoxicity assay 72 hrs Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability after 72 hrs by MTT colorimetric assay, IC50 = 0.82 μM. 25644672
S17 Cytotoxicity assay 72 hrs Cytotoxicity against mouse S17 cells assessed as reduction in cell viability after 72 hrs by MTT colorimetric assay, IC50 = 10.4 μM. 25644672
A549 Antiproliferative assay 3 days Antiproliferative activity against human A549 cells after 3 days by sulforhodamine B assay, IC50 = 0.8 μM. 25700232
HCT116 Antiproliferative assay 3 days Antiproliferative activity against human HCT116 cells after 3 days by sulforhodamine B assay, IC50 = 1.9 μM. 25700232
K562 Antiproliferative assay 3 days Antiproliferative activity against human K562 cells after 3 days by sulforhodamine B assay, IC50 = 3.1 μM. 25700232
MDA-MB-231 Antiproliferative assay 3 days Antiproliferative activity against human MDA-MB-231 cells after 3 days by sulforhodamine B assay, IC50 = 11 μM. 25700232
SKHEP1 Antiproliferative assay 3 days Antiproliferative activity against human SKHEP1 cells after 3 days by sulforhodamine B assay, IC50 = 1.1 μM. 25700232
SNU638 Antiproliferative assay 3 days Antiproliferative activity against human SNU638 cells after 3 days by sulforhodamine B assay, IC50 = 0.5 μM. 25700232
A549 Anticancer assay 48 hrs Anticancer activity against human A549 cells after 48 hrs by MTT assay, IC50 = 11.92 μM. 25744190
HL60 Anticancer assay 48 hrs Anticancer activity against human HL60 cells after 48 hrs by MTT assay, IC50 = 0.31 μM. 25744190
MCF7 Anticancer assay 48 hrs Anticancer activity against human MCF7 cells after 48 hrs by MTT assay, IC50 = 32.82 μM. 25744190
SMMC7721 Anticancer assay 48 hrs Anticancer activity against human SMMC7721 cells after 48 hrs by MTT assay, IC50 = 8.12 μM. 25744190
SW480 Anticancer assay 48 hrs Anticancer activity against human SW480 cells after 48 hrs by MTT assay, IC50 = 17.11 μM. 25744190
CCRF-CEM Cytotoxicity assay 72 hrs Cytotoxicity against human CCRF-CEM cells after 72 hrs by MTT assay, GI50 = 1.6 μM. 25792142
HT-29 Cytotoxicity assay 72 hrs Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay, GI50 = 31.6 μM. 25792142
MCF7 Cytotoxicity assay 72 hrs Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay, GI50 = 19.9 μM. 25792142
PC3 Cytotoxicity assay 72 hrs Cytotoxicity against human PC3 cells after 72 hrs by MTT assay, GI50 = 0.6 μM. 25792142
PC3 Cytotoxicity assay 72 hrs Cytotoxicity against human PC3 cells after 72 hrs by MTT assay, TGI = 4 μM. 25792142
DU145 Antiproliferative assay 72 hrs Antiproliferative activity against human DU145 cells assessed as cell viability incubated for 72 hrs by MTT assay, IC50 = 0.4 μM. 25799376
PC3 Antiproliferative assay 72 hrs Antiproliferative activity against human PC3 cells assessed as cell viability incubated for 72 hrs by MTT assay, IC50 = 4.33 μM. 25799376
U937 Cytotoxicity assay 24 hrs Cytotoxicity against human U937 cells after 24 hrs by MTT assay, IC50 = 1.5 μM. 25800433
MDA-MB-435 Cytotoxicity assay 72 hrs Cytotoxicity against human MDA-MB-435 cells assessed as cell growth inhibition after 72 hrs by MTT assay, IC50 = 2.81 μM. 25800514
HL60 Cytotoxicity assay 48 hrs Cytotoxicity against human HL60 cells assessed as growth inhibition after 48 hrs by trypan blue staining-based hemocytometric analysis, GI50 = 0.4 μM. 25874335
HBL100 Antiproliferative assay 48 hrs Antiproliferative activity against human HBL100 cells after 48 hrs incubation by SRB assay, GI50 = 1.9 μM. 25899335
HeLa Antiproliferative assay 48 hrs Antiproliferative activity against human HeLa cells after 48 hrs incubation by SRB assay, GI50 = 2 μM. 25899335
SW1573 Antiproliferative assay 48 hrs Antiproliferative activity against human SW1573 cells after 48 hrs incubation by SRB assay, GI50 = 3 μM. 25899335
T47D Antiproliferative assay 48 hrs Antiproliferative activity against human T47D cells after 48 hrs incubation by SRB assay, GI50 = 15 μM. 25899335
WiDr Antiproliferative assay 48 hrs Antiproliferative activity against human WiDr cells after 48 hrs incubation by SRB assay, GI50 = 26 μM. 25899335
K/VP.5 Cytotoxicity assay 72 hrs Cytotoxicity against etoposide-resistant human K/VP.5 cells assessed as cell growth inhibition after 72 hrs by MTS assay, IC50 = 2.5 μM. 25922181
K562 Cytotoxicity assay 72 hrs Cytotoxicity against human K562 cells assessed as cell growth inhibition after 72 hrs by MTS assay, IC50 = 0.163 μM. 25922181
DU145 Cytotoxicity assay 4 days Cytotoxicity against human DU145 cells measured on day 4 by CCK8 assay, IC50 = 2.09 μM. 25936262
HCT15 Cytotoxicity assay 4 days Cytotoxicity against human HCT15 cells measured on day 4 by CCK8 assay, IC50 = 18.87 μM. 25936262
HeLa Cytotoxicity assay 4 days Cytotoxicity against human HeLa cells measured on day 4 by CCK8 assay, IC50 = 7.32 μM. 25936262
T47D Cytotoxicity assay 4 days Cytotoxicity against human T47D cells measured on day 4 by CCK8 assay, IC50 = 13.7 μM. 25936262
NALM6 Cytotoxicity assay 5 days Cytotoxicity against human NALM6 cells expressing 50% TOP2A assessed as growth inhibition after 5 days by XTT assay, IC50 = 0.234 μM. 25945730
NALM6 Cytotoxicity assay 5 days Cytotoxicity against TOP2B double knockout human NALM6 cells assessed as growth inhibition after 5 days by XTT assay, IC50 = 0.182 μM. 25945730
NALM6 Cytotoxicity assay 5 days Cytotoxicity against wild type human NALM6 cells assessed as growth inhibition after 5 days by XTT assay, IC50 = 0.134 μM. 25945730
A549 Cytotoxicity assay 72 hrs Cytotoxicity against human A549 cells assessed as inhibition of cell proliferation after 72 hrs by sulforhodamine B assay, IC50 = 0.4 μM. 26010585
HCT116 Cytotoxicity assay 72 hrs Cytotoxicity against human HCT116 cells assessed as inhibition of cell proliferation after 72 hrs by sulforhodamine B assay, IC50 = 1.9 μM. 26010585
MDA-MB-231 Cytotoxicity assay 72 hrs Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell proliferation after 72 hrs by sulforhodamine B assay, IC50 = 7.7 μM. 26010585
SKHEP1 Cytotoxicity assay 72 hrs Cytotoxicity against human SKHEP1 cells assessed as inhibition of cell proliferation after 72 hrs by sulforhodamine B assay, IC50 = 2.8 μM. 26010585
SNU638 Cytotoxicity assay 72 hrs Cytotoxicity against human SNU638 cells assessed as inhibition of cell proliferation after 72 hrs by sulforhodamine B assay, IC50 = 0.3 μM. 26010585
DU145 Cytotoxicity assay 2 to 4 days Cytotoxicity against human DU145 cells incubated from day 2 to day 4 by CCK8 assay, IC50 = 0.5 μM. 26022080
HCT15 Cytotoxicity assay 2 to 4 days Cytotoxicity against human HCT15 cells incubated from day 2 to day 4 by CCK8 assay, IC50 = 1.1 μM. 26022080
HeLa Cytotoxicity assay 2 to 4 days Cytotoxicity against human HeLa cells incubated from day 2 to day 4 by CCK8 assay, IC50 = 1.41 μM. 26022080
T47D Cytotoxicity assay 2 to 4 days Cytotoxicity against human T47D cells incubated from day 2 to day 4 by CCK8 assay, IC50 = 0.7 μM. 26022080
KB Antiproliferative assay 72 hrs Antiproliferative activity against human KB cells after 72 hrs by methylene blue assay, IC50 = 1.5 μM. 26160020
KB-7d Antiproliferative assay 72 hrs Antiproliferative activity against human KB-7d cells expressing MRP after 72 hrs by methylene blue assay, IC50 = 46.1 μM. 26160020
KB-S15 Antiproliferative assay 72 hrs Antiproliferative activity against human KB-S15 cells expressing P-gp170/MDR after 72 hrs by methylene blue assay, IC50 = 3.5 μM. 26160020
KB-VIN10 Antiproliferative assay 72 hrs Antiproliferative activity against human KB-VIN10 cells expressing P-gp170/MDR after 72 hrs by methylene blue assay, IC50 = 26.4 μM. 26160020
A549 Cytotoxicity assay 48 hrs Cytotoxicity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by Hoechst assay, IC50 = 0.48 μM. 26225905
DLD1 Cytotoxicity assay 48 hrs Cytotoxicity against human DLD1 cells assessed as inhibition of cell growth incubated for 48 hrs by Hoechst assay, IC50 = 3.3 μM. 26225905
HepG2 Antiproliferative assay 72 hrs Antiproliferative activity against human HepG2 cells after 72 hrs by SRB assay, IC50 = 30 μM. 26291037
MDA-MB-231 Antiproliferative assay 72 hrs Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by SRB assay, IC50 = 3.6 μM. 26291037
MDA-MB-435 Antiproliferative assay 72 hrs Antiproliferative activity against human MDA-MB-435 cells after 72 hrs by SRB assay, IC50 = 1.7 μM. 26291037
PC3 Antiproliferative assay 72 hrs Antiproliferative activity against human PC3 cells after 72 hrs by SRB assay, IC50 = 1 μM. 26291037
A549 Cytotoxicity assay 48 hrs Cytotoxicity against human A549 cells after 48 hrs by MTT assay, IC50 = 38.5 μM. 26292628
DU145 Cytotoxicity assay 48 hrs Cytotoxicity against human DU145 cells after 48 hrs by MTT assay, IC50 = 5.21 μM. 26292628
HGC Cytotoxicity assay 48 hrs Cytotoxicity against human HGC cells after 48 hrs by MTT assay, IC50 = 10.9 μM. 26292628
MDA-MB-231 Cytotoxicity assay 48 hrs Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay, IC50 = 49.35 μM. 26292628
RWPE1 Cytotoxicity assay 48 hrs Cytotoxicity against human RWPE1 cells after 48 hrs by MTT assay, IC50 = 27.64 μM. 26292628
HCT15 Cytotoxicity assay 2 days Cytotoxicity against human HCT15 cells measured after 2 days by MTT assay, IC50 = 5.54 μM. 26334499
HeLa Cytotoxicity assay 2 days Cytotoxicity against human HeLa cells measured after 2 days by MTT assay, IC50 = 7.6 μM. 26334499
T47D Cytotoxicity assay 2 days Cytotoxicity against human T47D cells measured after 2 days by MTT assay, IC50 = 9.28 μM. 26334499
GBM2 Antiproliferative assay 72 hrs Antiproliferative activity against human GBM2 cells assessed as reduction in cell viability incubated for 72 hrs by WST-1 method, IC50 = 1.1 μM. 26355532
DU145 Cytotoxicity assay 2 days Cytotoxicity against human DU145 cells after 2 days by CCK8 assay, IC50 = 13.1 μM. 26361737
HCT15 Cytotoxicity assay 2 days Cytotoxicity against human HCT15 cells after 2 days by CCK8 assay, IC50 = 2.6 μM. 26361737
MCF10A Cytotoxicity assay 2 days Cytotoxicity against human MCF10A cells after 2 days by CCK8 assay, IC50 = 10.14 μM. 26361737
T47D Cytotoxicity assay 2 days Cytotoxicity against human T47D cells after 2 days by CCK8 assay, IC50 = 0.94 μM. 26361737
HepG2 Cytotoxicity assay 48 hrs Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay, IC50 = 33.98 μM. 26397393
MOLT3 Cytotoxicity assay 48 hrs Cytotoxicity against human MOLT3 cells after 48 hrs by XTT assay, IC50 = 0.041 μM. 26397393
A549 Cytotoxicity assay 48 hrs Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by resazurin assay, IC50 = 1.7 μM. 26592897
DLD1 Cytotoxicity assay 48 hrs Cytotoxicity against human DLD1 cells assessed as growth inhibition after 48 hrs by resazurin assay, IC50 = 2 μM. 26592897
A549 Antiproliferative assay 24 to 72 hrs Antiproliferative activity against human A549 cells after 24 to 72 hrs by SRB assay, IC50 = 0.8 μM. 26595875
CAKI-1 Antiproliferative assay 24 to 72 hrs Antiproliferative activity against human CAKI-1 cells after 24 to 72 hrs by SRB assay, IC50 = 1.1 μM. 26595875
HCT116 Antiproliferative assay 24 to 72 hrs Antiproliferative activity against human HCT116 cells after 24 to 72 hrs by SRB assay, IC50 = 3.3 μM. 26595875
HCT116 Antiproliferative assay 48 hrs Antiproliferative activity against human HCT116 cells assessed as cell viability after 48 hrs by SRB assay, IC50 = 2.3 μM. 26595875
HCT116 Antiproliferative assay 72 hrs Antiproliferative activity against human HCT116 cells assessed as cell viability after 72 hrs by SRB assay, IC50 = 0.3 μM. 26595875
K562 Antiproliferative assay 24 to 72 hrs Antiproliferative activity against human K562 cells after 24 to 72 hrs by SRB assay, IC50 = 6.7 μM. 26595875
HCT116 Antiproliferative assay 72 hrs Antiproliferative activity against p53-expressing human HCT116 cells assessed as cell viability after 72 hrs by SRB assay, IC50 = 1.1 μM. 26595875
HCT116 Antiproliferative assay 72 hrs Antiproliferative activity against p53-null human HCT116 cells assessed as cell viability after 72 hrs by SRB assay, IC50 = 3.1 μM. 26595875
A549 Antiproliferative assay 72 hrs Antiproliferative activity against human A549 cells assessed as growth inhibition after 72 hrs by CCK-8 assay, IC50 = 2.675 μM. 26615886
HeLa Antiproliferative assay 72 hrs Antiproliferative activity against human HeLa cells assessed as growth inhibition after 72 hrs by CCK-8 assay, IC50 = 1.605 μM. 26615886
HepG2 Antiproliferative assay 72 hrs Antiproliferative activity against human HepG2 cells assessed as growth inhibition after 72 hrs by CCK-8 assay, IC50 = 1.748 μM. 26615886
K562 Antiproliferative assay 72 hrs Antiproliferative activity against human K562 cells assessed as growth inhibition after 72 hrs by CCK-8 assay, IC50 = 0.413 μM. 26615886
K562/ADR Antiproliferative assay 72 hrs Antiproliferative activity against human K562/ADR cells assessed as growth inhibition after 72 hrs by CCK-8 assay, IC50 = 2.025 μM. 26615886
HCT116 Antiproliferative assay 72 hrs Antiproliferative activity against human HCT116 cells assessed as cell viability after 72 hrs by SRB assay, IC50 = 26.1 μM. 26618211
HeLa Antiproliferative assay 72 hrs Antiproliferative activity against human HeLa cells assessed as cell viability after 72 hrs by SRB assay, IC50 = 3.2 μM. 26618211
MDA-MB-231 Antiproliferative assay 72 hrs Antiproliferative activity against human MDA-MB-231 cells assessed as cell viability after 72 hrs by SRB assay, IC50 = 4.2 μM. 26618211
A549 Antiproliferative assay 48 hrs Antiproliferative activity against human A549 cells after 48 hrs by MTT assay, IC50 = 6.74 μM. 26649766
HeLa Antiproliferative assay 48 hrs Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay, IC50 = 32.45 μM. 26649766
HL60 Antiproliferative assay 48 hrs Antiproliferative activity against human HL60 cells after 48 hrs by MTT assay, IC50 = 0.16 μM. 26649766
HL60/MX2 Antiproliferative assay 48 hrs Antiproliferative activity against human HL60/MX2 cells after 48 hrs by MTT assay, IC50 = 9.02 μM. 26649766
K562 Antiproliferative assay 48 hrs Antiproliferative activity against human K562 cells after 48 hrs by MTT assay, IC50 = 0.51 μM. 26649766
MDA-MB-201 Antiproliferative assay 48 hrs Antiproliferative activity against human MDA-MB-201 cells after 48 hrs by MTT assay, IC50 = 31.33 μM. 26649766
Raji Antiproliferative assay 48 hrs Antiproliferative activity against human Raji cells after 48 hrs by MTT assay, IC50 = 1.68 μM. 26649766
HEK293 Cytotoxicity assay 48 hrs Cytotoxicity against HEK293 cells after 48 hrs by MTT assay, IC50 = 0.69 μM. 26649766
GM07492A Cytotoxicity assay 24 hrs Cytotoxicity against human GM07492A cells assessed as cell growth inhibition after 24 hrs by XTT assay, IC50 = 1.2 μM. 26649907
A549 Cytotoxicity assay 48 hrs Cytotoxicity against human A549 cells after 48 hrs by SRB assay, IC50 = 1.74 μM. 26706168
HCT15 Cytotoxicity assay 48 hrs Cytotoxicity against human HCT15 cells after 48 hrs by SRB assay, IC50 = 2.95 μM. 26706168
SK-MEL-2 Cytotoxicity assay 48 hrs Cytotoxicity against human SK-MEL-2 cells after 48 hrs by SRB assay, IC50 = 1.33 μM. 26706168
SKOV3 Cytotoxicity assay 48 hrs Cytotoxicity against human SKOV3 cells after 48 hrs by SRB assay, IC50 = 1.96 μM. 26706168
HT-29 Antiproliferative assay 72 hrs Antiproliferative activity against human HT-29 cells assessed as cellular DNA content after 72 hrs by CyQUANT NF fluorescence assay, IC50 = 2.2 μM. 26731300
MCF7 Antiproliferative assay 96 hrs Antiproliferative activity against human MCF7 cells assessed as cellular DNA content after 96 hrs by CyQUANT NF fluorescence assay, IC50 = 0.8 μM. 26731300
PC3 Antiproliferative assay 72 hrs Antiproliferative activity against human PC3 cells assessed as cellular DNA content after 72 hrs by CyQUANT NF fluorescence assay, IC50 = 1.1 μM. 26731300
T84 Antiproliferative assay 96 hrs Antiproliferative activity against human T84 cells assessed as cellular DNA content after 96 hrs by CyQUANT NF fluorescence assay, IC50 = 3 μM. 26731300
A375 Cytotoxicity assay 72 hrs Cytotoxicity against human A375 cells assessed as growth inhibition after 72 hrs by ATPlite assay, IC50 = 0.24 μM. 26793989
A549 Cytotoxicity assay 72 hrs Cytotoxicity against human A549 cells assessed as growth inhibition after 72 hrs by ATPlite assay, IC50 = 0.59 μM. 26793989
HL60 Cytotoxicity assay 72 hrs Cytotoxicity against human HL60 cells assessed as growth inhibition after 72 hrs by ATPlite assay, IC50 = 0.86 μM. 26793989
HCT116 Antiproliferative assay 48 hrs Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay, IC50 = 1.7 μM. 26804229
HepG2 Antiproliferative assay 48 hrs Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay, IC50 = 5.62 μM. 26804229
22Rv1 Antiproliferative assay 96 hrs Antiproliferative activity against human 22Rv1 cells after 96 hrs by propidium iodide-based monolayer assay, IC50 = 0.364 μM. 26854430
MCF7 Antiproliferative assay 96 hrs Antiproliferative activity against human MCF7 cells after 96 hrs by propidium iodide-based monolayer assay, IC50 = 1.264 μM. 26854430
A549 Cytotoxicity assay 48 hrs Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay, IC50 = 23.94 μM. 26873416
HCT8 Cytotoxicity assay 48 hrs Cytotoxicity against human HCT8 cells assessed as growth inhibition after 48 hrs by MTT assay, IC50 = 10.89 μM. 26873416
HeLa Cytotoxicity assay 48 hrs Cytotoxicity against human HeLa cells assessed as growth inhibition after 48 hrs by MTT assay, IC50 = 12.12 μM. 26873416
HepG2 Cytotoxicity assay 48 hrs Cytotoxicity against human HepG2 cells assessed as growth inhibition after 48 hrs by MTT assay, IC50 = 27.07 μM. 26873416
WI38 Cytotoxicity assay 48 hrs Cytotoxicity against human WI38 cells assessed as growth inhibition after 48 hrs by MTT assay, IC50 = 35.8 μM. 26873416
MCF7 Cytotoxicity assay 48 hrs Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay, IC50 = 12.4 μM. 26890115
MDA-MB-231 Cytotoxicity assay 48 hrs Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay, IC50 = 15.7 μM. 26890115
T47D Cytotoxicity assay 48 hrs Cytotoxicity against human T47D cells after 48 hrs by MTT assay, IC50 = 11.8 μM. 26890115
K562 Cytotoxicity assay 48 hrs Cytotoxicity against human K562 cells assessed as reduction in viable cells after 48 hrs by MTT assay, IC50 = 4.39 μM. 26916436
HONE1 Cytotoxicity assay 72 hrs Cytotoxicity against human HONE1 cells assessed as growth inhibition after 72 hrs by MTT assay, IC50 = 1.2 μM. 26920801
HT-29 Cytotoxicity assay 72 hrs Cytotoxicity against human HT-29 cells assessed as growth inhibition after 72 hrs by MTT assay, IC50 = 2 μM. 26920801
MCF7 Cytotoxicity assay 72 hrs Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTT assay, IC50 = 2.2 μM. 26920801
P388 Cytotoxicity assay 72 hrs Cytotoxicity against mouse P388 cells assessed as growth inhibition after 72 hrs by MTT assay, IC50 = 1.3 μM. 26920801
HCT15 Cytotoxicity assay 3 days Cytotoxicity against human HCT15 cells after 3 days by CCK8 assay, IC50 = 2.82 μM. 26927425
HeLa Cytotoxicity assay 3 days Cytotoxicity against human HeLa cells after 3 days by CCK8 assay, IC50 = 0.18 μM. 26927425
T47D Cytotoxicity assay 3 days Cytotoxicity against human T47D cells after 3 days by CCK8 assay, IC50 = 1.84 μM. 26927425
DU145 Cytotoxicity assay 48 hrs Cytotoxicity against human DU145 cells after 48 hrs by CCK8 assay, IC50 = 2.09 μM. 26945111
HCT15 Cytotoxicity assay 48 hrs Cytotoxicity against human HCT15 cells after 48 hrs by CCK8 assay, IC50 = 18.87 μM. 26945111
HeLa Cytotoxicity assay 48 hrs Cytotoxicity against human HeLa cells after 48 hrs by CCK8 assay, IC50 = 7.32 μM. 26945111
T47D Cytotoxicity assay 48 hrs Cytotoxicity against human T47D cells after 48 hrs by CCK8 assay, IC50 = 13.7 μM. 26945111
BT474 Antiproliferative assay 72 hrs Antiproliferative activity against human BT474 cells after 72 hrs by CCK8 assay, IC50 = 6.6 μM. 26988802
HCT15 Antiproliferative assay 72 hrs Antiproliferative activity against human HCT15 cells after 72 hrs by CCK8 assay, IC50 = 6.9 μM. 26988802
T47D Antiproliferative assay 72 hrs Antiproliferative activity against human T47D cells after 72 hrs by CCK8 assay, IC50 = 6.4 μM. 26988802
A549 Antiproliferative assay 48 hrs Antiproliferative activity against human A549 cells after 48 hrs by MTT assay, IC50 = 3.82 μM. 27060757
CCRF-CEM Antiproliferative assay 48 hrs Antiproliferative activity against human CCRF-CEM cells after 48 hrs by MTT assay, IC50 = 0.12 μM. 27060757
HCT116 Antiproliferative assay 48 hrs Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay, IC50 = 6.03 μM. 27060757
HeLa Antiproliferative assay 48 hrs Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay, IC50 = 41.21 μM. 27060757
A375 Antiproliferative assay 72 hrs Antiproliferative activity against human A375 cells assessed as reduction in cell viability after 72 hrs by ATPlite assay, IC50 = 0.24 μM. 27096049
A549 Antiproliferative assay 72 hrs Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 72 hrs by ATPlite assay, IC50 = 0.59 μM. 27096049
HL60 Antiproliferative assay 72 hrs Antiproliferative activity against human HL60 cells assessed as reduction in cell viability after 72 hrs by ATPlite assay, IC50 = 0.86 μM. 27096049
HL60 Cytotoxicity assay 72 hrs Cytotoxicity against human HL60 cells assessed as cell growth inhibition after 72 hrs by MTT assay, IC50 = 0.5 μM. 27145162
MOLT3 Cytotoxicity assay 72 hrs Cytotoxicity against human MOLT3 cells assessed as cell growth inhibition after 72 hrs by MTT assay, IC50 = 0.7 μM. 27145162
HEK293T Cytotoxicity assay 36 hrs Cytotoxicity against HEK293T cells after 36 hrs by MTT assay, IC50 = 11.47 μM. 27262599
A549 Cytotoxicity assay 36 hrs Cytotoxicity against human A549 cells after 36 hrs by MTT assay, IC50 = 8.01 μM. 27262599
HeLa Cytotoxicity assay 36 hrs Cytotoxicity against human HeLa cells after 36 hrs by MTT assay, IC50 = 4.39 μM. 27262599
MCF7 Cytotoxicity assay 36 hrs Cytotoxicity against human MCF7 cells after 36 hrs by MTT assay, IC50 = 1.74 μM. 27262599
HEK293 Anticlonogenic assay 48 hrs Anticlonogenic activity against HEK293 cells assessed as inhibition of colony formation incubated for 48 hrs measured after 6 days by crystal violet staining based assay, LC50 = 20 μM. 27343852
HEK293 Cytotoxicity assay 48 hrs Cytotoxicity against HEK293 cells assessed as reduction in cell viability after 48 hrs by MTT assay, LC50 = 22 μM. 27343852
H460 Antiproliferative assay 72 hrs Antiproliferative activity against human H460 cells after 72 hrs by MTT assay, IC50 = 0.1 μM. 27448912
HCT116 Antiproliferative assay 72 hrs Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay, IC50 = 5 μM. 27448912
MCF7 Antiproliferative assay 72 hrs Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay, IC50 = 1 μM. 27448912
shGFP-fused HMLE Antiproliferative assay 72 hrs Antiproliferative activity against human shGFP-fused HMLE cells after 72 hrs by MTT assay, IC50 = 0.4 μM. 27448912
HCT15 Cytotoxicity assay 72 hrs Cytotoxicity against human HCT15 cells assessed as reduction in cell growth after 72 hrs by CCK8 assay, IC50 = 1.06 μM. 27484510
HeLa Cytotoxicity assay 72 hrs Cytotoxicity against human HeLa cells assessed as reduction in cell growth after 72 hrs by CCK8 assay, IC50 = 10.03 μM. 27484510
NCI-N87 Cytotoxicity assay 72 hrs Cytotoxicity against human NCI-N87 cells assessed as reduction in cell growth after 72 hrs by CCK8 assay, IC50 = 1.29 μM. 27484510
T47D Cytotoxicity assay 72 hrs Cytotoxicity against human T47D cells assessed as reduction in cell growth after 72 hrs by CCK8 assay, IC50 = 2.8 μM. 27484510
K562 Antiproliferative assay 72 hrs Antiproliferative activity against human K562 cells measured after 72 hrs by CCK8 assay, IC50 = 0.345 μM. 27484511
K562/ADR Antiproliferative assay 72 hrs Antiproliferative activity against human K562/ADR cells measured after 72 hrs by CCK8 assay, IC50 = 2.211 μM. 27484511
A549 Cytotoxicity assay 48 hrs Cytotoxicity against human A549 cells measured after 48 hrs by MTT assay, IC50 = 29.7 μM. 27517805
HCT8 Cytotoxicity assay 48 hrs Cytotoxicity against human HCT8 cells measured after 48 hrs by MTT assay, IC50 = 10 μM. 27517805
HeLa Cytotoxicity assay 48 hrs Cytotoxicity against human HeLa cells measured after 48 hrs by MTT assay, IC50 = 13.5 μM. 27517805
HepG2 Cytotoxicity assay 48 hrs Cytotoxicity against human HepG2 cells measured after 48 hrs by MTT assay, IC50 = 5.21 μM. 27517805
WI38 Cytotoxicity assay 48 hrs Cytotoxicity against human WI38 cells measured after 48 hrs by MTT assay, IC50 = 17.6 μM. 27517805
HEK293 Cytotoxicity assay 24 hrs Cytotoxicity against HEK293 cells assessed as reduction in cell viability after 24 hrs by MTT assay, IC50 = 0.6 μM. 27533261
H1975-1 Cytotoxicity assay 72 hrs Cytotoxicity against human H1975-1 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay, IC50 = 9.5 μM. 27560280
HeLa Cytotoxicity assay 72 hrs Cytotoxicity against human HeLa cells assessed as reduction in cell viability measured after 72 hrs by MTT assay, IC50 = 8.2 μM. 27560280
HL60 Cytotoxicity assay 72 hrs Cytotoxicity against human HL60 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay, IC50 = 2.1 μM. 27560280
Vero Cytotoxicity assay 72 hrs Cytotoxicity against human Vero cells assessed as reduction in cell viability measured after 72 hrs by MTT assay, IC50 = 1.5 μM. 27560280
HCT116 Cytotoxicity assay 72 hrs Cytotoxicity against resistant human HCT116 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay, IC50 = 2.8 μM. 27560280
HL60 Cytotoxicity assay 72 hrs Cytotoxicity against human HL60 cells assessed as cell growth inhibition after 72 hrs by MTT assay, IC50 = 0.3 μM. 27598828
HEK293 Antiproliferative assay 72 hrs Antiproliferative activity against HEK293 cells after 72 hrs by CCK8 assay, IC50 = 1.74 μM. 27643560
DU145 Antiproliferative assay 72 hrs Antiproliferative activity against human DU145 cells after 72 hrs by CCK8 assay, IC50 = 0.02 μM. 27643560
HCT15 Antiproliferative assay 72 hrs Antiproliferative activity against human HCT15 cells after 72 hrs by CCK8 assay, IC50 = 1.1 μM. 27643560
HeLa Antiproliferative assay 72 hrs Antiproliferative activity against human HeLa cells after 72 hrs by CCK8 assay, IC50 = 0.18 μM. 27643560
T47D Antiproliferative assay 72 hrs Antiproliferative activity against human T47D cells after 72 hrs by CCK8 assay, IC50 = 1.84 μM. 27643560
DU145 Antiproliferative assay 72 hrs Antiproliferative activity against human DU145 cells measured after 72 hrs by CCK8 assay, IC50 = 2.19 μM. 27654394
HCT15 Antiproliferative assay 72 hrs Antiproliferative activity against human HCT15 cells measured after 72 hrs by CCK8 assay, IC50 = 1.27 μM. 27654394
MCF7 Antiproliferative assay 72 hrs Antiproliferative activity against human MCF7 cells measured after 72 hrs by CCK8 assay, IC50 = 35.55 μM. 27654394
T47D Antiproliferative assay 72 hrs Antiproliferative activity against human T47D cells measured after 72 hrs by CCK8 assay, IC50 = 4.85 μM. 27654394
HBL100 Cytotoxicity assay 48 hrs Cytotoxicity against human HBL100 cells assessed as growth inhibition after 48 hrs by SRB assay, GI50 = 1.4 μM. 27765506
HeLa Cytotoxicity assay 48 hrs Cytotoxicity against human HeLa cells assessed as growth inhibition after 48 hrs by SRB assay, GI50 = 3.3 μM. 27765506
SW1573 Cytotoxicity assay 48 hrs Cytotoxicity against human SW1573 cells assessed as growth inhibition after 48 hrs by SRB assay, GI50 = 15 μM. 27765506
WiDr Cytotoxicity assay 48 hrs Cytotoxicity against human WiDr cells assessed as growth inhibition after 48 hrs by SRB assay, GI50 = 23 μM. 27765506
MCF7 Cytotoxicity assay 72 hrs Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay, IC50 = 27.41 μM. 27863370
MDA-MB-231 Cytotoxicity assay 72 hrs Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by MTT assay, IC50 = 13.35 μM. 27863370
T47D Cytotoxicity assay 72 hrs Cytotoxicity against human T47D cells assessed as reduction in cell viability after 72 hrs by MTT assay, IC50 = 9.8 μM. 27863370
HEK293T Cytotoxicity assay 48 hrs Cytotoxicity against HEK293T cells assessed as cells growth inhibition after 48 hrs by MTT assay, IC50 = 22 μM. 27994737
MCF7 Cytotoxicity assay 48 hrs Cytotoxicity against human MCF7 cells assessed as cell growth inhibition after 48 hrs by SRB assay, GI50 = 0.56 μM. 28041801
TK10 Cytotoxicity assay 48 hrs Cytotoxicity against human TK10 cells assessed as cell growth inhibition after 48 hrs by SRB assay, GI50 = 7.19 μM. 28041801
TK10 Cytotoxicity assay 48 hrs Cytotoxicity against human TK10 cells assessed as cell growth inhibition after 48 hrs by SRB assay, TGI = 49.74 μM. 28041801
UACC62 Cytotoxicity assay 48 hrs Cytotoxicity against human UACC62 cells assessed as cell growth inhibition after 48 hrs by SRB assay, GI50 = 0.89 μM. 28041801
THP1 Cytotoxicity assay 72 hrs Cytotoxicity against human THP1 cells assessed as reduction in cell viability after 72 hrs by MTT assay, IC50 = 1.82 μM. 28062194
U937 Cytotoxicity assay 72 hrs Cytotoxicity against human U937 cells assessed as reduction in cell viability after 72 hrs by MTT assay, IC50 = 1.1 μM. 28062194
EL4 Cytotoxicity assay 72 hrs Cytotoxicity against mouse EL4 cells assessed as reduction in cell viability after 72 hrs by MTT assay, IC50 = 4.9 μM. 28062194
S17 Cytotoxicity assay 72 hrs Cytotoxicity against mouse S17 cells assessed as reduction in cell viability after 72 hrs by MTT assay, IC50 = 10.4 μM. 28062194
A549 Cytotoxicity assay 48 hrs Cytotoxicity against human A549 cells assessed as cell growth inhibition after 48 hrs by MTT assay, IC50 = 5.87 μM. 28068602
DU145 Cytotoxicity assay 48 hrs Cytotoxicity against human DU145 cells assessed as cell growth inhibition after 48 hrs by MTT assay, IC50 = 3.1 μM. 28068602
MDA-MB-231 Cytotoxicity assay 48 hrs Cytotoxicity against human MDA-MB-231 cells assessed as cell growth inhibition after 48 hrs by MTT assay, IC50 = 20.3 μM. 28068602
PC3 Cytotoxicity assay 48 hrs Cytotoxicity against human PC3 cells assessed as cell growth inhibition after 48 hrs by MTT assay, IC50 = 13.9 μM. 28068602
HCT15 Antiproliferative assay 72 hrs Antiproliferative activity against human HCT15 cells after 72 hrs by CCK8 assay, IC50 = 5.4 μM. 28068603
HeLa Antiproliferative assay 72 hrs Antiproliferative activity against human HeLa cells after 72 hrs by CCK8 assay, IC50 = 9.1 μM. 28068603
T47D Antiproliferative assay 72 hrs Antiproliferative activity against human T47D cells after 72 hrs by CCK8 assay, IC50 = 7 μM. 28068603
HepG2 Cytotoxicity assay 48 hrs Cytotoxicity against human HepG2 cells assessed as growth inhibition after 48 hrs by Cell Titer-Glo assay, EC50 = 15.9 μM. 28080063
HEK293 Antiproliferative assay 48 hrs Antiproliferative activity against HEK293 cells after 48 hrs by SRB assay, IC50 = 7.51 μM. 28094224
DLD1 Antiproliferative assay 48 hrs Antiproliferative activity against human DLD1 cells after 48 hrs by SRB assay, IC50 = 8.11 μM. 28094224
DU145 Antiproliferative assay 48 hrs Antiproliferative activity against human DU145 cells after 48 hrs by SRB assay, IC50 = 10.64 μM. 28094224
FADU Antiproliferative assay 48 hrs Antiproliferative activity against human FADU cells after 48 hrs by SRB assay, IC50 = 16.01 μM. 28094224
A549 Cytotoxicity assay 48 hrs Cytotoxicity against human A549 cells after 48 hrs by SRB assay, IC50 = 0.92 μM. 28165740
BT549 Cytotoxicity assay 48 hrs Cytotoxicity against human BT549 cells after 48 hrs by SRB assay, IC50 = 1.24 μM. 28165740
SK-MEL-2 Cytotoxicity assay 48 hrs Cytotoxicity against human SK-MEL-2 cells after 48 hrs by SRB assay, IC50 = 1.1 μM. 28165740
SKOV3 Cytotoxicity assay 48 hrs Cytotoxicity against human SKOV3 cells after 48 hrs by SRB assay, IC50 = 1.95 μM. 28165740
HepG2 Cytotoxicity assay 48 hrs Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay, IC50 = 0.83 μM. 28169166
LO2 Cytotoxicity assay 48 hrs Cytotoxicity against human LO2 cells assessed as reduction in cell viability after 48 hrs by MTT assay, IC50 = 3.78 μM. 28169166
SMMC7721 Cytotoxicity assay 48 hrs Cytotoxicity against human SMMC7721 cells assessed as reduction in cell viability after 48 hrs by MTT assay, IC50 = 0.15 μM. 28169166
HCT15 Antiproliferative assay 24 hrs Antiproliferative activity against human HCT15 cells after 24 hrs by WST-1 assay, IC50 = 19.7 μM. 28181805
HeLaS3 Antiproliferative assay 24 hrs Antiproliferative activity against human HeLaS3 cells after 24 hrs by WST-1 assay, IC50 = 43.1 μM. 28181805
HCT15 Antiproliferative assay 72 hrs Antiproliferative activity against human HCT15 cells after 72 hrs by CCK8 assay, IC50 = 1.33 μM. 28384547
HeLa Antiproliferative assay 72 hrs Antiproliferative activity against human HeLa cells after 72 hrs by CCK8 assay, IC50 = 3.2 μM. 28384547
T47D Antiproliferative assay 72 hrs Antiproliferative activity against human T47D cells after 72 hrs by CCK8 assay, IC50 = 3.25 μM. 28384547
Vero Cytotoxicity assay 72 hrs Cytotoxicity against African green monkey Vero cells assessed as decrease in cell viability after 72 hrs by MTT assay, IC50 = 16 μM. 28385594
HCT116 Cytotoxicity assay 72 hrs Cytotoxicity against human HCT116 cells assessed as decrease in cell viability after 72 hrs by MTT assay, IC50 = 3 μM. 28385594
HeLa Cytotoxicity assay 72 hrs Cytotoxicity against human HeLa cells assessed as decrease in cell viability after 72 hrs by MTT assay, IC50 = 8 μM. 28385594
HL60 Cytotoxicity assay 72 hrs Cytotoxicity against human HL60 cells assessed as decrease in cell viability after 72 hrs by MTT assay, IC50 = 20 μM. 28385594
K562 Cytotoxicity assay 72 hrs Cytotoxicity against human K562 cells assessed as decrease in cell viability after 72 hrs by MTT assay, IC50 = 12 μM. 28385594
A549 Growth inhibition assay 72 hrs Growth inhibition of human A549 cells after 72 hrs by MTT assay, GI50 = 1.7 μM. 28406636
Hs683 Growth inhibition assay 72 hrs Growth inhibition of human Hs683 cells after 72 hrs by MTT assay, GI50 = 1.5 μM. 28406636
MCF7 Growth inhibition assay 72 hrs Growth inhibition of human MCF7 cells after 72 hrs by MTT assay, GI50 = 4 μM. 28406636
SK-MEL-28 Growth inhibition assay 72 hrs Growth inhibition of human SK-MEL-28 cells after 72 hrs by MTT assay, GI50 = 3.2 μM. 28406636
U373 Growth inhibition assay 72 hrs Growth inhibition of human U373 cells after 72 hrs by MTT assay, GI50 = 24.9 μM. 28406636
HeLa Cytotoxicity assay 72 hrs Cytotoxicity against human HeLa cells after 72 hrs by MTT assay, IC50 = 7.89 μM. 28431878
MDA-MB-231 Cytotoxicity assay 72 hrs Cytotoxicity against human MDA-MB-231 cells after 72 hrs by MTT assay, IC50 = 29.27 μM. 28431878
SMMC7721 Cytotoxicity assay 72 hrs Cytotoxicity against human SMMC7721 cells after 72 hrs by MTT assay, IC50 = 40.44 μM. 28431878
A549 Antiproliferative assay 48 hrs Antiproliferative activity against human A549 cells after 48 hrs by MTT assay, IC50 = 19.83 μM. 28462840
HeLa Antiproliferative assay 48 hrs Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay, IC50 = 15.93 μM. 28462840
MCF7 Antiproliferative assay 48 hrs Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay, IC50 = 24.01 μM. 28462840
MGC803 Antiproliferative assay 48 hrs Antiproliferative activity against human MGC803 cells after 48 hrs by MTT assay, IC50 = 20.91 μM. 28462840
A549 Cytotoxicity assay 48 hrs Cytotoxicity against human A549 cells after 48 hrs by MTT assay, IC50 = 14.7 μM. 28512026
HCT8 Cytotoxicity assay 48 hrs Cytotoxicity against human HCT8 cells after 48 hrs by MTT assay, IC50 = 26.3 μM. 28512026
HeLa Cytotoxicity assay 48 hrs Cytotoxicity against human HeLa cells after 48 hrs by MTT assay, IC50 = 24.9 μM. 28512026
HepG2 Cytotoxicity assay 48 hrs Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay, IC50 = 13.4 μM. 28512026
WI38 Cytotoxicity assay 48 hrs Cytotoxicity against human WI38 cells after 48 hrs by MTT assay, IC50 = 46.9 μM. 28512026
A549 Growth inhibition assay 72 hrs Growth inhibition of human A549 cells incubated for 72 hrs by sulforhodamine B assay, IC50 = 0.3 μM. 28625715
HCT116 Growth inhibition assay 72 hrs Growth inhibition of human HCT116 cells incubated for 72 hrs by sulforhodamine B assay, IC50 = 1.06 μM. 28625715
K562 Growth inhibition assay 72 hrs Growth inhibition of human K562 cells incubated for 72 hrs by sulforhodamine B assay, IC50 = 0.76 μM. 28625715
MDA-MB-231 Growth inhibition assay 72 hrs Growth inhibition of human MDA-MB-231 cells incubated for 72 hrs by sulforhodamine B assay, IC50 = 1.53 μM. 28625715
MRC5 Growth inhibition assay 72 hrs Growth inhibition of human MRC5 cells incubated for 72 hrs by sulforhodamine B assay, IC50 = 11.73 μM. 28625715
SKHEP1 Growth inhibition assay 72 hrs Growth inhibition of human SKHEP1 cells incubated for 72 hrs by sulforhodamine B assay, IC50 = 0.63 μM. 28625715
SNU638 Growth inhibition assay 72 hrs Growth inhibition of human SNU638 cells incubated for 72 hrs by sulforhodamine B assay, IC50 = 1.05 μM. 28625715
HCT15 Antiproliferative assay 72 hrs Antiproliferative activity against human HCT15 cells after 72 hrs by CCK8 assay, IC50 = 9.27 μM. 28633898
HeLa Antiproliferative assay 72 hrs Antiproliferative activity against human HeLa cells after 72 hrs by CCK8 assay, IC50 = 4.12 μM. 28633898
T47D Antiproliferative assay 72 hrs Antiproliferative activity against human T47D cells after 72 hrs by CCK8 assay, IC50 = 8.81 μM. 28633898
HeLa Cytotoxicity assay 72 hrs Cytotoxic activity against human HeLa cells after 72 hrs by MTT assay, IC50 = 7.21 μM. 28733083
MDA-MB-231 Cytotoxicity assay 72 hrs Cytotoxic activity against human MDA-MB-231 cells after 72 hrs by MTT assay, IC50 = 16.27 μM. 28733083
SMMC7721 Cytotoxicity assay 72 hrs Cytotoxic activity against human SMMC7721 cells after 72 hrs by MTT assay, IC50 = 21.03 μM. 28733083
A549 Cytotoxicity assay 24 hrs Cytotoxicity against human A549 cells after 24 hrs by MTT assay, IC50 = 6.21 μM. 28757065
HeLa Cytotoxicity assay 24 hrs Cytotoxicity against human HeLa cells after 24 hrs by MTT assay, IC50 = 1.58 μM. 28757065
HepG2 Cytotoxicity assay 24 hrs Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay, IC50 = 5.52 μM. 28757065
L02 Cytotoxicity assay 24 hrs Cytotoxicity against human L02 cells after 24 hrs by MTT assay, IC50 = 7.75 μM. 28757065
MCF7 Cytotoxicity assay 24 hrs Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay, IC50 = 2.08 μM. 28757065
A549 Cytotoxicity assay 48 hrs Cytotoxicity against human A549 cells after 48 hrs by SRB assay, IC50 = 1.1 μM. 28841320
BT549 Cytotoxicity assay 48 hrs Cytotoxicity against human BT549 cells after 48 hrs by SRB assay, IC50 = 1 μM. 28841320
SK-MEL-2 Cytotoxicity assay 48 hrs Cytotoxicity against human SK-MEL-2 cells after 48 hrs by SRB assay, IC50 = 0.2 μM. 28841320
SKOV3 Cytotoxicity assay 48 hrs Cytotoxicity against human SKOV3 cells after 48 hrs by SRB assay, IC50 = 2.9 μM. 28841320
SK-MEL-1 Cytotoxicity assay 72 hrs Cytotoxicity against human SK-MEL-1 cells assessed as reduction in cell viability after 72 hrs by MTT assay, IC50 = 8 μM. 29032930
A549 Antiproliferative assay 72 hrs Antiproliferative activity against human A549 cells after 72 hrs by MTT assay, IC50 = 1.3 μM. 29077404
DU145 Antiproliferative assay 72 hrs Antiproliferative activity against human DU145 cells after 72 hrs by MTT assay, IC50 = 1 μM. 29077404
HeLa Antiproliferative assay 72 hrs Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay, IC50 = 2.4 μM. 29077404
MCF7 Antiproliferative assay 72 hrs Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay, IC50 = 10.5 μM. 29077404
A549 Antiproliferative assay 48 hrs Antiproliferative activity against human A549 cells after 48 hrs by SRB assay, GI50 = 1.5 μM. 29129514
HBL100 Antiproliferative assay 48 hrs Antiproliferative activity against human HBL100 cells after 48 hrs by SRB assay, GI50 = 2.3 μM. 29129514
HeLa Antiproliferative assay 48 hrs Antiproliferative activity against human HeLa cells after 48 hrs by SRB assay, GI50 = 3 μM. 29129514
SW1573 Antiproliferative assay 48 hrs Antiproliferative activity against human SW1573 cells after 48 hrs by SRB assay, GI50 = 15 μM. 29129514
T47D Antiproliferative assay 48 hrs Antiproliferative activity against human T47D cells after 48 hrs by SRB assay, GI50 = 22 μM. 29129514
WiDr Antiproliferative assay 48 hrs Antiproliferative activity against human WiDr cells after 48 hrs by SRB assay, GI50 = 23 μM. 29129514
A549 Cytotoxicity assay 48 hrs Cytotoxicity against human A549 cells assessed as reduction in inhibition of cell growth incubated for 48 hrs by MTT assay, IC50 = 9.1 μM. 29248296
HeLa Cytotoxicity assay 48 hrs Cytotoxicity against human HeLa cells assessed as reduction in inhibition of cell growth incubated for 48 hrs by MTT assay, IC50 = 11.2 μM. 29248296
HepG2 Cytotoxicity assay 48 hrs Cytotoxicity against human HepG2 cells assessed as reduction in inhibition of cell growth incubated for 48 hrs by MTT assay, IC50 = 9.2 μM. 29248296
LoVo Cytotoxicity assay 48 hrs Cytotoxicity against human LoVo cells assessed as reduction in inhibition of cell growth incubated for 48 hrs by MTT assay, IC50 = 18.7 μM. 29248296
WI38 Cytotoxicity assay 48 hrs Cytotoxicity against human WI38 cells assessed as reduction in inhibition of cell growth incubated for 48 hrs by MTT assay, IC50 = 25.7 μM. 29248296
A549 Cytotoxicity assay 48 hrs Cytotoxicity against human A549 cells after 48 hrs by MTT assay, IC50 = 2.03 μM. 29269253
DU145 Cytotoxicity assay 48 hrs Cytotoxicity against human DU145 cells after 48 hrs by MTT assay, IC50 = 2.03 μM. 29269253
HeLa Cytotoxicity assay 48 hrs Cytotoxicity against human HeLa cells after 48 hrs by MTT assay, IC50 = 2.03 μM. 29269253
MCF7 Cytotoxicity assay 48 hrs Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay, IC50 = 2.03 μM. 29269253
A549 Cytotoxicity assay 48 hrs Cytotoxicity against human A549 cells after 48 hrs by MTT assay, IC50 = 2.27 μM. 29289881
DU145 Cytotoxicity assay 48 hrs Cytotoxicity against human DU145 cells after 48 hrs by MTT assay, IC50 = 1.97 μM. 29289881
HeLa Cytotoxicity assay 48 hrs Cytotoxicity against human HeLa cells after 48 hrs by MTT assay, IC50 = 1.93 μM. 29289881
HT-29 Cytotoxicity assay 48 hrs Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay, IC50 = 1.64 μM. 29289881
MDA-MB-231 Cytotoxicity assay 48 hrs Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay, IC50 = 1.91 μM. 29289881
A549 Antiproliferative assay 48 hrs Antiproliferative activity against human A549 cells after 48 hrs by MTT assay, IC50 = 1.97 μM. 29289884
DU145 Antiproliferative assay 48 hrs Antiproliferative activity against human DU145 cells after 48 hrs by MTT assay, IC50 = 2.35 μM. 29289884
HeLa Antiproliferative assay 48 hrs Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay, IC50 = 2.71 μM. 29289884
HepG2 Antiproliferative assay 48 hrs Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay, IC50 = 2.84 μM. 29289884
HT-29 Antiproliferative assay 48 hrs Antiproliferative activity against human HT-29 cells after 48 hrs by MTT assay, IC50 = 1.87 μM. 29289884
MCF7 Antiproliferative assay 48 hrs Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay, IC50 = 1.62 μM. 29289884
A549 Cytotoxicity assay 48 hrs Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay, IC50 = 32.61 μM. 29335211
HeLa Cytotoxicity assay 48 hrs Cytotoxicity against human HeLa cells assessed as growth inhibition after 48 hrs by MTT assay, IC50 = 22.35 μM. 29335211
HL60 Cytotoxicity assay 48 hrs Cytotoxicity against human HL60 cells assessed as growth inhibition after 48 hrs by MTT assay, IC50 = 0.19 μM. 29335211
PC3 Cytotoxicity assay 48 hrs Cytotoxicity against human PC3 cells assessed as growth inhibition after 48 hrs by MTT assay, IC50 = 5.73 μM. 29335211
HCT15 Antiproliferative assay 72 hrs Antiproliferative activity against human HCT15 cells incubated for 72 hrs by CCK8 assay, IC50 = 2.94 μM. 29402741
HeLa Antiproliferative assay 72 hrs Antiproliferative activity against human HeLa cells incubated for 72 hrs by CCK8 assay, IC50 = 9.21 μM. 29402741
T47D Antiproliferative assay 72 hrs Antiproliferative activity against human T47D cells incubated for 72 hrs by CCK8 assay, IC50 = 0.4 μM. 29402741
HCT15 Antiproliferative assay 72 hrs Antiproliferative activity against human HCT15 cells after 72 hrs by CCK-8 assay, IC50 = 2.45 μM. 29510948
HeLa Antiproliferative assay 72 hrs Antiproliferative activity against human HeLa cells after 72 hrs by CCK-8 assay, IC50 = 10.03 μM. 29510948
T47D Antiproliferative assay 72 hrs Antiproliferative activity against human T47D cells after 72 hrs by CCK-8 assay, IC50 = 0.32 μM. 29510948
A549 Cytotoxicity assay 48 hrs Cytotoxicity against human A549 cells assessed as cell growth inhibition after 48 hrs by MTT assay, IC50 = 3.25 μM. 29525336
DU145 Cytotoxicity assay 48 hrs Cytotoxicity against human DU145 cells assessed as cell growth inhibition after 48 hrs by MTT assay, IC50 = 2.13 μM. 29525336
HCT116 Cytotoxicity assay 48 hrs Cytotoxicity against human HCT116 cells assessed as cell growth inhibition after 48 hrs by MTT assay, IC50 = 2.6 μM. 29525336
HT-29 Cytotoxicity assay 48 hrs Cytotoxicity against human HT-29 cells assessed as cell growth inhibition after 48 hrs by MTT assay, IC50 = 1.8 μM. 29525336
MCF7 Cytotoxicity assay 48 hrs Cytotoxicity against human MCF7 cells assessed as cell growth inhibition after 48 hrs by MTT assay, IC50 = 2.03 μM. 29525336
PC3 Cytotoxicity assay 48 hrs Cytotoxicity against human PC3 cells assessed as cell growth inhibition after 48 hrs by MTT assay, IC50 = 5.4 μM. 29525336
A549 Cytotoxicity assay 48 hrs Cytotoxicity against human A549 cells after 48 hrs by MTT assay, IC50 = 13.71 μM. 29545100
HeLa Cytotoxicity assay 48 hrs Cytotoxicity against human HeLa cells after 48 hrs by MTT assay, IC50 = 32.05 μM. 29545100
HL60 Cytotoxicity assay 48 hrs Cytotoxicity against human HL60 cells after 48 hrs by MTT assay, IC50 = 0.33 μM. 29545100
K562 Cytotoxicity assay 48 hrs Cytotoxicity against human K562 cells after 48 hrs by MTT assay, IC50 = 8.45 μM. 29545100
K562 Cytotoxicity assay 72 hrs Cytotoxicity against human etoposide-sensitive K562 cells after 72 hrs by CellTiter96 AQueous one solution cell proliferation assay, IC50 = 1.22 μM. 29656990
HT-29 Cytotoxicity assay 24 to 72 hrs Cytotoxicity against human HT-29 cells measured after 24 to 72 hrs by SRB assay, IC50 = 15 μM. 29656990
K/VP.5 Cytotoxicity assay 72 hrs Cytotoxicity against human K/VP.5 cells after 72 hrs by CellTiter96 AQueous one solution cell proliferation assay, IC50 = 35.36 μM. 29656990
OVCAR3 Cytotoxicity assay 24 to 72 hrs Cytotoxicity against human OVCAR3 cells measured after 24 to 72 hrs by SRB assay, IC50 = 2.9 μM. 29656990
CCRF-CEM Cytotoxicity assay 72 hrs Cytotoxicity against human CCRF-CEM cells assessed as growth inhibition after 72 hrs by MTT assay, GI50 = 1.26 μM. 29670691
HT-29 Cytotoxicity assay 72 hrs Cytotoxicity against human HT-29 cells assessed as growth inhibition after 72 hrs by MTT assay, GI50 = 31.62 μM. 29670691
K562 Cytotoxicity assay 72 hrs Cytotoxicity against human K562 cells assessed as growth inhibition after 72 hrs by MTT assay, GI50 = 12.59 μM. 29670691
MCF7 Cytotoxicity assay 72 hrs Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTT assay, GI50 = 19.95 μM. 29670691
PC3 Cytotoxicity assay 72 hrs Cytotoxicity against human PC3 cells assessed as growth inhibition after 72 hrs by MTT assay, GI50 = 0.63 μM. 29670691
K562 Antiproliferative assay 72 hrs Antiproliferative activity against human K562 cells after 72 hrs by CCK8 assay, IC50 = 0.764 μM. 29678463
K562/VCR Antiproliferative assay 72 hrs Antiproliferative activity against human K562/VCR cells after 72 hrs by CCK8 assay, IC50 = 11.84 μM. 29678463
HepG2 Cytotoxicity assay 72 hrs Cytotoxicity against human HepG2 cells assessed as reduction in cell proliferation after 72 hrs by MTS assay, IC50 = 20.1 μM. 29778894
A549 Cytotoxicity assay 72 hrs Cytotoxicity against human A549 cells assessed as growth inhibition after 72 hrs by MTT assay, IC50 = 9.4695 μM. 29886322
L02 Cytotoxicity assay 72 hrs Cytotoxicity against human L02 cells assessed as growth inhibition after 72 hrs by MTT assay, IC50 = 3.4805 μM. 29886322
MCF7 Cytotoxicity assay 72 hrs Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTT assay, IC50 = 4.7165 μM. 29886322
A549 Cytotoxicity assay 72 hrs Cytotoxicity against human A549 cells after 72 hrs by sulforhodamine B assay, IC50 = 0.72 μM. 29893558
HCT116 Cytotoxicity assay 72 hrs Cytotoxicity against human HCT116 cells after 72 hrs by sulforhodamine B assay, IC50 = 0.68 μM. 29893558
K562 Cytotoxicity assay 72 hrs Cytotoxicity against human K562 cells after 72 hrs by sulforhodamine B assay, IC50 = 1.3 μM. 29893558
MDA-MB-231 Cytotoxicity assay 72 hrs Cytotoxicity against human MDA-MB-231 cells after 72 hrs by sulforhodamine B assay, IC50 = 4.4 μM. 29893558
SKHEP1 Cytotoxicity assay 72 hrs Cytotoxicity against human SKHEP1 cells after 72 hrs by sulforhodamine B assay, IC50 = 0.93 μM. 29893558
SNU638 Cytotoxicity assay 72 hrs Cytotoxicity against human SNU638 cells after 72 hrs by sulforhodamine B assay, IC50 = 0.43 μM. 29893558
A549 Cytotoxicity assay 72 hrs Cytotoxicity against human A549 cells assessed as growth inhibition after 72 hrs by SRB assay, IC50 = 0.3 μM. 30041947
HCT116 Cytotoxicity assay 72 hrs Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by SRB assay, IC50 = 1.06 μM. 30041947
K562 Cytotoxicity assay 72 hrs Cytotoxicity against human K562 cells assessed as growth inhibition after 72 hrs by SRB assay, IC50 = 0.76 μM. 30041947
MDA-MB-231 Cytotoxicity assay 72 hrs Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 72 hrs by SRB assay, IC50 = 1.53 μM. 30041947
MRC5 Cytotoxicity assay 72 hrs Cytotoxicity against human MRC5 cells assessed as growth inhibition after 72 hrs by SRB assay, IC50 = 11.73 μM. 30041947
SKHEP1 Cytotoxicity assay 72 hrs Cytotoxicity against human SKHEP1 cells assessed as growth inhibition after 72 hrs by SRB assay, IC50 = 0.63 μM. 30041947
SNU638 Cytotoxicity assay 72 hrs Cytotoxicity against human SNU638 cells assessed as growth inhibition after 72 hrs by SRB assay, IC50 = 1.05 μM. 30041947
CCRF-CEM Antiproliferative assay 72 hrs Antiproliferative activity against human CCRF-CEM cells after 72 hrs by MTT assay, GI50 = 1.6 μM. 30071406
HT-29 Antiproliferative assay 72 hrs Antiproliferative activity against human HT-29 cells after 72 hrs by MTT assay, GI50 = 31.6 μM. 30071406
MCF7 Antiproliferative assay 72 hrs Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay, GI50 = 19.9 μM. 30071406
PC3 Antiproliferative assay 72 hrs Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay, GI50 = 0.6 μM. 30071406
PC3 Antiproliferative assay 72 hrs Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay, TGI = 4 μM. 30071406
HCT15 Antiproliferative assay 72 hrs Antiproliferative activity against human HCT15 cells after 72 hrs by EZ-CYTOX reagent based assay, IC50 = 2.94 μM. 30262132
HeLa Antiproliferative assay 72 hrs Antiproliferative activity against human HeLa cells after 72 hrs by EZ-CYTOX reagent based assay, IC50 = 9.21 μM. 30262132
T47D Antiproliferative assay 72 hrs Antiproliferative activity against human T47D cells after 72 hrs by EZ-CYTOX reagent based assay, IC50 = 0.4 μM. 30262132
A549 Cytotoxicity assay 48 hrs Cytotoxicity against human A549 cells after 48 hrs by MTT assay, IC50 = 22.5 μM. 30265994
HeLa Cytotoxicity assay 48 hrs Cytotoxicity against human HeLa cells after 48 hrs by MTT assay, IC50 = 21.4 μM. 30265994
HepG2 Cytotoxicity assay 48 hrs Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay, IC50 = 20 μM. 30265994
HL7702 Cytotoxicity assay 48 hrs Cytotoxicity against human HL7702 cells after 48 hrs by MTT assay, IC50 = 24.6 μM. 30265994
MRC5 Cytotoxicity assay 48 hrs Cytotoxicity against human MRC5 cells after 48 hrs by MTT assay, IC50 = 33.5 μM. 30265994
MOLT-3 Growth Inhibition Assay IC50=0.051 ± 0.002 μM 25078311
HepG2 Growth Inhibition Assay IC50=30.16 ± 0.50 μM 25078311
T47D Growth Inhibition Assay IC50=3.18 ± 0.11 μM 25603122
HCT15 Growth Inhibition Assay IC50=0.81 ± 0.01 μM 25603122
DU145 Growth Inhibition Assay IC50=2.28 ± 0.04 μM 25603122
HEK293 Growth Inhibition Assay IC50=7.14 ± 0.36 μM 25603122
SK-N-ASCis24 Growth Inhibition Assay IC50=0.57 ± 0.11 μM 25960282
SK-N-AS Growth Inhibition Assay IC50=0.24 ± 0.03 μM 25960282
KellyCis83 Growth Inhibition Assay IC50=0.16 ± 0.02 μM 25960282
Kelly Growth Inhibition Assay IC50=0.12 ± 0.01 μM 25960282
MIAPACA Growth Inhibition Assay GI50=1.3 ± 0.03 μM 24953821
MCF-7 Growth Inhibition Assay GI50=0.25 ± 0.1 μM 24953821
HeLa Growth Inhibition Assay GI50=0.64 ± 0.4 μM 24953821
HCT116 Cytotoxicity assay Cytotoxicity against HCT116 cells., IC50 = 2.5 μM. 7473578
CCRF CEM Function assay Tested for the inhibitory activity against CCRF CEM T- cell leukemia cells, IC50 = 0.002 μM. 7932571
KB ATCC Function assay 50% reduction in the number of KB ATCC cells, ID50 = 0.32 μM. 8120864
SCLC Cytotoxicity assay Cytotoxicity against human SCLC cells resistant to cisplatin (SCLC/CDDP), IC50 = 1.3 μM. 8258835
HeLa Function assay Tested for inhibition of topoisomerase II isolated from HeLa cells by DNA-cleavage assay, EC50 = 0.81 μM. 8410993
KB Growth inhibition assay Compound concentration required to reduce the exponential growth of KB cells by 50%, CC50 = 0.1 μM. 9767632
MT-4 Growth inhibition assay Compound concentration required to reduce the exponential growth of MT-4 cells by 50%, CC50 = 0.08 μM. 9767632
L1210 Cytotoxicity assay In vitro cytotoxic activity against murine L1210 leukemia cells., IC50 = 0.2 μM. 9804687
HL-60 Cytotoxicity assay Relative cytotoxicity against human promyelocytic leukemia(HL-60) cells, IC50 = 0.367 μM. 10377219
HL-60 Cytotoxicity assay Relative cytotoxicity against human promyelocytic leukemia(HL-60) cells, IC90 = 0.73 μM. 10377219
A549 Function assay GI values against A549 cells (lung cancer), GI50 = 6.30957 μM. 11311065
CAKI-1 Function assay GI values against CAKI-1 cells(renal carcinoma), GI50 = 6.30957 μM. 11311065
KB Function assay GI values against KB cells (nasopharyngeal carcinoma), GI50 = 0.19953 μM. 11311065
HEL Function assay Inhibitory activity against human cytomegalovirus (HCMV) in HEL cells, ED50 = 8.64 μM. 11311065
A549 Cytotoxicity assay Cytotoxicity against human A549 cells by MTT assay, IC50 = 0.5 μM. 11473438
HL60 Cytotoxicity assay Cytotoxicity against human HL60 cells by MTT assay, IC50 = 5.4 μM. 11473438
MCF7 Cytotoxicity assay Cytotoxicity against human MCF7 cells by MTT assay, IC50 = 12.3 μM. 11473438
P388 Cytotoxicity assay Cytotoxicity against mouse P388 cells by MTT assay, IC50 = 0.1 μM. 11473438
HT-29 Cytotoxicity assay Tested for cytotoxicity against Colon carcinoma type HT-29 cell line expressing MDR-1 (-) gene; 35% of cells were affected, IC50 = 10 μM. 11844671
KB Function assay Compound concentration required to reduce the cell proliferation of Wild type and Drug- resistant human nasopharyngeal carcinoma KB cells by 50%, IC50 = 0.6 μM. 12431048
P388 Growth inhibition assay Growth inhibitory activity against murine P388 leukemia cells, IC50 = 0.15 μM. 12620081
HL60 Apoptosis assay In vitro concentration required to induce apoptosis in HL60 cells, AC50 = 0.45 μM. 12877593
HL60R Apoptosis assay In vitro concentration required to induce apoptosis in HL60R cells, AC50 = 15 μM. 12877593
HL60 Function assay In vitro inhibitory concentration against proliferation of HL60 cells, IC50 = 0.123 μM. 12877593
HL60R Function assay In vitro inhibitory concentration against proliferation of HL60R cells, IC50 = 6.5 μM. 12877593
HL60R Function assay In vitro inhibitory concentration against proliferation of HL60R cells along with 5 (uM) verapamil, IC50 = 0.5 μM. 12877593
HL60 Cytotoxicity assay Cytotoxicity against human HL60 cells by MTT assay, IC50 = 0.2 μM. 14738377
KB Cytotoxicity assay Cytotoxicity against human KB cells, ID50 = 0.2 μM. 14987069
KB Cytotoxicity assay Cytotoxicity against human KB cells, LD50 = 3 μM. 14987069
MCF7 Cytotoxicity assay Cytotoxicity against human MCF7 cells, GI50 = 4.36516 μM. 14987069
MOLT4 Cytotoxicity assay Cytotoxicity against human MOLT4 cells, GI50 = 1.02329 μM. 14987069
HeLa Function assay Concentration required to inhibit S phase and G2/M phase in HeLa cells, Concentration = 2 μM. 15026047
HeLa Growth inhibition assay Growth inhibitory concentration of compound was determined against HeLa cells by alamar blue assay, GI50 = 40 μM. 15026047
A549 Function assay Effective dose on human lung carcinoma (A549) cells, ED50 = 3.39 μM. 15914002
A549 Cytotoxicity assay Cytotoxicity against human A549 cells by SRB assay, IC50 = 1.16 μM. 17194596
HCT116 Cytotoxicity assay Cytotoxicity against human HCT116 cells by SRB assay, IC50 = 1.87 μM. 17194596
HL60 Cytotoxicity assay Cytotoxicity against human HL60 cells by SRB assay, IC50 = 0.37 μM. 17194596
HT1080 Cytotoxicity assay Cytotoxicity against human HT1080 cells by SRB assay, IC50 = 0.25 μM. 17194596
SK-MEL-2 Cytotoxicity assay Cytotoxicity against human SK-MEL-2 cells by SRB assay, IC50 = 5.72 μM. 17194596
SK-OV-3 Cytotoxicity assay Cytotoxicity against human SK-OV-3 cells by SRB assay, IC50 = 4.28 μM. 17194596
SNU638 Cytotoxicity assay Cytotoxicity against human SNU638 cells by SRB assay, IC50 = 0.23 μM. 17194596
XF498 Cytotoxicity assay Cytotoxicity against human XF498 cells by SRB assay, IC50 = 3.48 μM. 17194596
HCT116 Cytotoxicity assay Cytotoxicity against human HCT116 cells by XTT assay, IC50 = 1.7 μM. 17368022
MCF7 Cytotoxicity assay Cytotoxicity against human MCF7 cells by XTT assay, IC50 = 35.6 μM. 17368022
MDA-MB468 Cytotoxicity assay Cytotoxicity against human MDA-MB468 cells by XTT assay, IC50 = 13.6 μM. 17368022
mouse astrocyte cells Antiproliferative assay Antiproliferative activity against mouse astrocyte cells by MTT assay, EC50 = 0.433 μM. 17417631
mouse medulloblastoma cells Antiproliferative assay Antiproliferative activity against mouse medulloblastoma cells harboring heterozygous ptch1 gene by MTT assay, EC50 = 0.208 μM. 17417631
mouse neural precursor cells Antiproliferative assay Antiproliferative activity against mouse neural precursor cells by MTT assay, EC50 = 0.34 μM. 17417631
H460 Growth inhibition assay Growth inhibition of human H460 cells by MTT assay, IC50 = 0.2 μM. 17482821
HeLa Growth inhibition assay Growth inhibition of human HeLa cells by MTT assay, IC50 = 2.9 μM. 17482821
MiaPaCa2 Growth inhibition assay Growth inhibition of human MiaPaCa2 cells by MTT assay, IC50 = 15.4 μM. 17482821
SW620 Growth inhibition assay Growth inhibition of human SW620 cells by MTT assay, IC50 = 20 μM. 17482821
A549 Cytotoxicity assay Cytotoxicity against human A549 cells by SRB microtiter plate assay, IC50 = 1.4 μM. 17585747
DU145 Cytotoxicity assay Cytotoxicity against human DU145 cells by SRB microtiter plate assay, IC50 = 2.4 μM. 17585747
KB Cytotoxicity assay Cytotoxicity against human KB cells by SRB microtiter plate assay, IC50 = 4.8 μM. 17585747
ZR751 Cytotoxicity assay Cytotoxicity against human ZR751cells by SRB microtiter plate assay, IC50 = 3.1 μM. 17585747
HL60/MX2 Cytotoxicity assay Cytotoxicity against DNA topoisomerase-2 deficient human HL60/MX2 cells by MTT assay, GI50 = 5.98 μM. 17962028
502713 Cytotoxicity assay Cytotoxicity against human 502713 cells by sulforhodamine B assay, IC50 = 2.42 μM. 17988764
A549 Cytotoxicity assay Cytotoxicity against human A549 cells by sulforhodamine B assay, IC50 = 5.62 μM. 17988764
DU145 Cytotoxicity assay Cytotoxicity against human DU145 cells by sulforhodamine B assay, IC50 = 3.85 μM. 17988764
HCT-15 Cytotoxicity assay Cytotoxicity against human HCT-15 cells by sulforhodamine B assay, IC50 = 1.48 μM. 17988764
HEP2 Cytotoxicity assay Cytotoxicity against human HEP2 cells by sulforhodamine B assay, IC50 = 2.15 μM. 17988764
PC-3 Cytotoxicity assay Cytotoxicity against human PC-3 cells by sulforhodamine B assay, IC50 = 17.4 μM. 17988764
SF295 Cytotoxicity assay Cytotoxicity against human SF295 cells by sulforhodamine B assay, IC50 = 13.3 μM. 17988764
MCF7 Cytotoxicity assay Cytotoxicity against human MCF7 cells by XTT assay, IC50 = 35.6 μM. 18093835
DU145 Cytotoxicity assay Cytotoxicity against human DU145 cells, IC50 = 29.79 μM. 18178085
HCT116 Cytotoxicity assay Cytotoxicity against human HCT116 cells, IC50 = 15.11 μM. 18178085
HeLa Cytotoxicity assay Cytotoxicity against human HeLa cells, IC50 = 18.24 μM. 18178085
HL60 Cytotoxicity assay Cytotoxicity against human HL60 cells, IC50 = 1.44 μM. 18178085
MDA-MB-231 Cytotoxicity assay Cytotoxicity against human MDA-MB-231 cells, IC50 = 16.25 μM. 18178085
NCI-H520 Growth inhibition assay Growth inhibition of human NCI-H520 cells, GI50 = 13.5 μM. 18502124
PC3 Growth inhibition assay Growth inhibition of human PC3 cells, GI50 = 12.5 μM. 18502124
SK-Hep1 Cytotoxicity assay Cytotoxicity against human SK-Hep1 cells by MTT assay, IC50 = 49.6 μM. 18637688
HL60 Cytotoxicity assay Cytotoxicity against human HL60 cells by SRB assay, IC50 = 0.2 μM. 18651771
A549 Cytotoxicity assay Cytotoxicity against human A549 cells assessed as reduction of cell growth by SRB method, IC50 = 9.98 μM. 18782668
KB Cytotoxicity assay Cytotoxicity against human KB cells assessed as reduction of cell growth by SRB method, IC50 = 14.2 μM. 18782668
A375 Cytotoxicity assay Cytotoxicity against human A375 cells by MTT assay, IC50 = 3.92 μM. 19036584
A549 Cytotoxicity assay Cytotoxicity against human A549 cells by MTT assay, IC50 = 9.51 μM. 19036584
HL60 Cytotoxicity assay Cytotoxicity against human HL60 cells by MTT assay, IC50 = 1.83 μM. 19036584
THP1 Cytotoxicity assay Cytotoxicity against human THP1 cells by MTT assay, IC50 = 2.16 μM. 19036584
HCT15 Antiproliferative assay Antiproliferative activity against human HCT15 cells by SRB assay, GI50 = 1.25 μM. 19394218
MESSA Antiproliferative assay Antiproliferative activity against human MESSA cells by SRB assay, GI50 = 0.21 μM. 19394218
HCT15/CLO2 Antiproliferative assay Antiproliferative activity against multidrug resistant human HCT15/CLO2 cells by SRB assay, GI50 = 10.02 μM. 19394218
MES-SA/Dx5 Antiproliferative assay Antiproliferative activity against multidrug resistant human MES-SA/Dx5 cells by SRB assay, GI50 = 9.72 μM. 19394218
A375 Cytotoxicity assay Cytotoxicity against human A375 cells by MTT assay, IC50 = 3.92 μM. 19782567
A549 Cytotoxicity assay Cytotoxicity against human A549 cells by MTT assay, IC50 = 9.51 μM. 19782567
HL60 Cytotoxicity assay Cytotoxicity against human HL60 cells by MTT assay, IC50 = 2.16 μM. 19782567
THP1 Cytotoxicity assay Cytotoxicity against human THP1 cells by MTT assay, IC50 = 1.83 μM. 19782567
H69 Cytotoxicity assay Cytotoxicity against human adriamycin resistant H69 cells, IC50 = 46 μM. 19788270
HeLa Cytotoxicity assay Cytotoxicity against human HeLa cells, IC50 = 0.4 μM. 19788270
HuCCa1 Cytotoxicity assay Cytotoxicity against human HuCCa1 cells, IC50 = 5.1 μM. 19788270
KB Cytotoxicity assay Cytotoxicity against human KB cells, IC50 = 0.5 μM. 19788270
MDA-MB-231 Cytotoxicity assay Cytotoxicity against human MDA-MB-231 cells, IC50 = 0.3 μM. 19788270
T47D Cytotoxicity assay Cytotoxicity against human T47D cells, IC50 = 0.1 μM. 19788270
DU145 Cytotoxicity assay Cytotoxicity against human DU145 cells by MTT assay, IC50 = 5.16 μM. 19836231
HeLa Cytotoxicity assay Cytotoxicity against human HeLa cells by MTT assay, IC50 = 2.15 μM. 19836231
HL60 Cytotoxicity assay Cytotoxicity against human HL60 cells by MTT assay, IC50 = 0.93 μM. 19836231
HT-29 Cytotoxicity assay Cytotoxicity against human HT-29 cells by MTT assay, IC50 = 6.32 μM. 19836231
MDA-MB-231 Cytotoxicity assay Cytotoxicity against human MDA-MB-231 cells by MTT assay, IC50 = 3.5 μM. 19836231
KB Cytotoxicity assay Cytotoxicity against human KB cells, EC50 = 1.1 μM. 20102168
DU145 Cytotoxicity assay Cytotoxicity against human DU145 cells in presence of 10% fetal bovine serum, IC50 = 2.45 μM. 20188578
HCT15 Cytotoxicity assay Cytotoxicity against human HCT15 cells in presence of 10% fetal bovine serum, IC50 = 1.29 μM. 20188578
HeLa Cytotoxicity assay Cytotoxicity against human HeLa cells in presence of 10% fetal bovine serum, IC50 = 1.57 μM. 20188578
K562 Cytotoxicity assay Cytotoxicity against human K562 cells in presence of 10% fetal bovine serum, IC50 = 2.84 μM. 20188578
HeLa Cytotoxicity assay Cytotoxicity against human HeLa cells by MTT assay, IC50 = 8.93 μM. 20356735
HL60 Cytotoxicity assay Cytotoxicity against human HL60 cells by MTT assay, IC50 = 1.81 μM. 20356735
HL60 Cytotoxicity assay Cytotoxicity against human HL60 cells, IC50 = 0.49 μM. 20863598
NCI60 Growth inhibition assay Growth inhibition of human NCI60 cells by SBR assay, GI50 = 38.9045 μM. 21035334
DU145 Cytotoxicity assay Cytotoxicity against human DU145 cells by MTT assay, IC50 = 1.44 μM. 21115246
HCT15 Cytotoxicity assay Cytotoxicity against human HCT15 cells by MTT assay, IC50 = 2.03 μM. 21115246
K562 Cytotoxicity assay Cytotoxicity against human K562 cells by MTT assay, IC50 = 1.21 μM. 21115246
MCF7 Cytotoxicity assay Cytotoxicity against human MCF7 cells by MTT assay, IC50 = 1.98 μM. 21115246
HepG2 Cytotoxicity assay Cytotoxicity against human HepG2 cells by MTT assay, IC50 = 15.8 μM. 21174408
MOLT3 Cytotoxicity assay Cytotoxicity against human MOLT3 cells by XTT assay, IC50 = 0.03 μM. 21174408
A549 Cytotoxicity assay Cytotoxicity against human A549 cells by SRB assay, IC50 = 1.85 μM. 21182258
SK-MEL-2 Cytotoxicity assay Cytotoxicity against human SK-MEL-2 cells by SRB assay, IC50 = 1.17 μM. 21182258
SKOV3 Cytotoxicity assay Cytotoxicity against human SKOV3 cells by SRB assay, IC50 = 1.81 μM. 21182258
XF498 Cytotoxicity assay Cytotoxicity against human XF498 cells by SRB assay, IC50 = 1.72 μM. 21182258
A549 Anticancer assay Anticancer activity against human A549 cells by SRB assay, IC50 = 1.85 μM. 21420296
SK-MEL-2 Anticancer assay Anticancer activity against human SK-MEL-2 cells by SRB assay, IC50 = 1.17 μM. 21420296
SKOV3 Anticancer assay Anticancer activity against human SKOV3 cells by SRB assay, IC50 = 1.81 μM. 21420296
XF498 Anticancer assay Anticancer activity against human XF498 cells by SRB assay, IC50 = 1.72 μM. 21420296
HL60 Cytotoxicity assay Cytotoxicity against human HL60 cells, IC50 = 1.4 μM. 21439821
HL60/MX2 Cytotoxicity assay Cytotoxicity against human HL60/MX2 cells, IC50 = 15.75 μM. 21439821
A549 Cytotoxicity assay Cytotoxicity against human A549 cells by sulforhodamine B assay, IC50 = 0.44 μM. 21936523
SK-MEL-2 Cytotoxicity assay Cytotoxicity against human SK-MEL-2 cells by sulforhodamine B assay, IC50 = 0.41 μM. 21936523
SKOV3 Cytotoxicity assay Cytotoxicity against human SKOV3 cells by sulforhodamine B assay, IC50 = 1.31 μM. 21936523
HBL100 Growth inhibition assay Growth inhibition of human HBL100 cells, GI50 = 2.3 μM. 21986585
HeLa Growth inhibition assay Growth inhibition of human HeLa cells, GI50 = 3 μM. 21986585
Ishikawa Growth inhibition assay Growth inhibition of human Ishikawa cells, GI50 = 11 μM. 21986585
SW1573 Growth inhibition assay Growth inhibition of human SW1573 cells, GI50 = 15 μM. 21986585
T47D Growth inhibition assay Growth inhibition of human T47D cells, GI50 = 22 μM. 21986585
WiDr Growth inhibition assay Growth inhibition of human WiDr cells, GI50 = 23 μM. 21986585
Bel7402 Cytotoxicity assay Cytotoxicity against human Bel7402 cells, IC50 = 0.08 μM. 23092389
HeLa Cytotoxicity assay Cytotoxicity against human HeLa cells, IC50 = 0.08 μM. 23092389
SGC7901 Cytotoxicity assay Cytotoxicity against human SGC7901 cells, IC50 = 0.08 μM. 23092389
P388 Cytotoxicity assay Cytotoxicity against mouse P388 cells, IC50 = 0.08 μM. 23092389
SNU638 Cytotoxicity assay Cytotoxicity against human SNU638 cells by MTT assay, IC50 = 2.57 μM. 23608763
T47D Cytotoxicity assay Cytotoxicity against human T47D cells by MTT assay, IC50 = 4.98 μM. 23608763
H460 Cytotoxicity assay Cytotoxicity against human H460 cells assessed as growth inhibition by MTT assay, IC50 = 30 μM. 23920485
MCF7 Cytotoxicity assay Cytotoxicity against human MCF7 cells assessed as growth inhibition by MTT assay, IC50 = 20.9 μM. 23920485
PC3 Cytotoxicity assay Cytotoxicity against human PC3 cells assessed as growth inhibition by MTT assay, IC50 = 18.2 μM. 23920485
HeLa Cytotoxicity assay Cytotoxicity against human HeLa cells by MTT assay, IC50 = 0.0057 μM. 24422592
BGC823 Cytotoxicity assay Cytotoxicity against human BGC823 cells, IC50 = 25.72 μM. 24775914
HepG2 Cytotoxicity assay Cytotoxicity against human HepG2 cells, IC50 = 1.15 μM. 24775914
KB Antiproliferative assay Antiproliferative activity against human KB cells, IC50 = 1.1 μM. 25059503
KB-S15 Antiproliferative assay Antiproliferative activity against human KB-S15 cells, IC50 = 3.5 μM. 25059503
KB-VIN10 Antiproliferative assay Antiproliferative activity against human KB-VIN10 cells, IC50 = 23 μM. 25059503
SKMES1 Cytotoxicity assay Cytotoxicity against human SKMES1 cells, IC50 = 1.83 μM. 25440884
HepG2 Cytotoxicity assay Cytotoxicity against human HepG2 cells by MTT assay, IC50 = 40.47 μM. 25747499
MOLT3 Cytotoxicity assay Cytotoxicity against human MOLT3 cells by XTT assay, IC50 = 0.11 μM. 25747499
MCF7 Cytotoxicity assay Cytotoxicity against human MCF7 cells by MTT assay, IC50 = 7.6 μM. 25847767
MDA-MB-231 Cytotoxicity assay Cytotoxicity against human MDA-MB-231 cells by MTT assay, IC50 = 10.3 μM. 25847767
T47D Cytotoxicity assay Cytotoxicity against human T47D cells by MTT assay, IC50 = 8.9 μM. 25847767
A549 Antiproliferative assay Antiproliferative activity against human A549 cells by MTT assay, IC50 = 18.2 μM. 26216018
HepG2 Antiproliferative assay Antiproliferative activity against human HepG2 cells by MTT assay, IC50 = 20.9 μM. 26216018
A549 Cytotoxicity assay Cytotoxicity in human A549 cells by SRB assay, IC50 = 1.4 μM. 26812172
HCT116 Cytotoxicity assay Cytotoxicity in human HCT116 cells by SRB assay, IC50 = 1 μM. 26812172
SK-MEL-2 Cytotoxicity assay Cytotoxicity in human SK-MEL-2 cells by SRB assay, IC50 = 1.5 μM. 26812172
SKOV3 Cytotoxicity assay Cytotoxicity in human SKOV3 cells by SRB assay, IC50 = 2.6 μM. 26812172
A549 Cytotoxicity assay Cytotoxicity against human A549 cells by SRB assay, IC50 = 1.85 μM. 26988298
SK-MEL-2 Cytotoxicity assay Cytotoxicity against human SK-MEL-2 cells by SRB assay, IC50 = 1.17 μM. 26988298
SKOV3 Cytotoxicity assay Cytotoxicity against human SKOV3 cells by SRB assay, IC50 = 0.84 μM. 26988298
XF498 Cytotoxicity assay Cytotoxicity against human XF498 cells by SRB assay, IC50 = 1.72 μM. 26988298
HL60 Cytotoxicity assay Cytotoxicity against human HL60 cells assessed as reduction in cell survival, IC50 = 0.025 μM. 27234147
HepG2 Cytotoxicity assay Cytotoxicity against human HepG2 cells by MTT assay, IC50 = 15.8 μM. 27759375
HCT116 Cytotoxicity assay Cytotoxicity against human HCT116 cells assessed as growth inhibition by MTS assay, IC50 = 0.49 μM. 28055208
A549 Cytotoxicity assay Cytotoxicity against human A549 cells assessed as reduction in cell viability by MTT assay, IC50 = 16.6 μM. 28571311
HeLa Cytotoxicity assay Cytotoxicity against human HeLa cells assessed as reduction in cell viability by MTT assay, IC50 = 15 μM. 28571311
HepG2 Cytotoxicity assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability by MTT assay, IC50 = 16.1 μM. 28571311
MCF7 Cytotoxicity assay Cytotoxicity against human MCF7 cells by MTT assay, IC50 = 12.4 μM. 28886509
HeLaS3 Antiproliferative assay Antiproliferative activity against human HeLaS3 cells by MTT assay, IC50 = 0.5 μM. 29072457
HT-29 Antiproliferative assay Antiproliferative activity against human HT-29 cells by MTT assay, IC50 = 7.6 μM. 29072457
K562 Antiproliferative assay Antiproliferative activity against human K562 cells, IC50 = 0.3 μM. 29871847
K/VP.5 Function assay Inhibition of human topoisomerase-2 in etoposide-resistant K/VP.5 cells assessed as growth inhibition, IC50 = 5.1 μM. 29871847
RH-1 Growth inhibition assay IC50 = 0.01778 μM SANGER
A253 Growth inhibition assay IC50 = 0.01843 μM SANGER
HT-144 Growth inhibition assay IC50 = 0.02009 μM SANGER
EW-16 Growth inhibition assay IC50 = 0.02148 μM SANGER
NTERA-S-cl-D1 Growth inhibition assay IC50 = 0.02502 μM SANGER
KE-37 Growth inhibition assay IC50 = 0.04072 μM SANGER
SK-UT-1 Growth inhibition assay IC50 = 0.04237 μM SANGER
OCUB-M Growth inhibition assay IC50 = 0.04455 μM SANGER
8-MG-BA Growth inhibition assay IC50 = 0.04687 μM SANGER
TE-9 Growth inhibition assay IC50 = 0.05593 μM SANGER
CGTH-W-1 Growth inhibition assay IC50 = 0.05741 μM SANGER
BB30-HNC Growth inhibition assay IC50 = 0.06418 μM SANGER
ACN Growth inhibition assay IC50 = 0.07896 μM SANGER
EW-13 Growth inhibition assay IC50 = 0.08885 μM SANGER
DU-4475 Growth inhibition assay IC50 = 0.09615 μM SANGER
HGC-27 Growth inhibition assay IC50 = 0.10212 μM SANGER
A427 Growth inhibition assay IC50 = 0.10338 μM SANGER
HT-1080 Growth inhibition assay IC50 = 0.10853 μM SANGER
MC-IXC Growth inhibition assay IC50 = 0.11512 μM SANGER
MRK-nu-1 Growth inhibition assay IC50 = 0.1162 μM SANGER
EW-7 Growth inhibition assay IC50 = 0.12506 μM SANGER
SW982 Growth inhibition assay IC50 = 0.13069 μM SANGER
SIG-M5 Growth inhibition assay IC50 = 0.13082 μM SANGER
PA-1 Growth inhibition assay IC50 = 0.13219 μM SANGER
ES8 Growth inhibition assay IC50 = 0.14221 μM SANGER
MV-4-11 Growth inhibition assay IC50 = 0.15121 μM SANGER
QIMR-WIL Growth inhibition assay IC50 = 0.15458 μM SANGER
COLO-679 Growth inhibition assay IC50 = 0.16303 μM SANGER
CCRF-CEM Growth inhibition assay IC50 = 0.17043 μM SANGER
IGROV-1 Growth inhibition assay IC50 = 0.17072 μM SANGER
LOUCY Growth inhibition assay IC50 = 0.1766 μM SANGER
ML-2 Growth inhibition assay IC50 = 0.17847 μM SANGER
RS4-11 Growth inhibition assay IC50 = 0.19612 μM SANGER
DJM-1 Growth inhibition assay IC50 = 0.20294 μM SANGER
ATN-1 Growth inhibition assay IC50 = 0.20386 μM SANGER
NALM-6 Growth inhibition assay IC50 = 0.20584 μM SANGER
HUTU-80 Growth inhibition assay IC50 = 0.21676 μM SANGER
REH Growth inhibition assay IC50 = 0.22424 μM SANGER
NCI-H2030 Growth inhibition assay IC50 = 0.22992 μM SANGER
A204 Growth inhibition assay IC50 = 0.23248 μM SANGER
NCI-H460 Growth inhibition assay IC50 = 0.23571 μM SANGER
697 Growth inhibition assay IC50 = 0.2432 μM SANGER
KYSE-270 Growth inhibition assay IC50 = 0.25188 μM SANGER
ES1 Growth inhibition assay IC50 = 0.25434 μM SANGER
COLO-205 Growth inhibition assay IC50 = 0.26497 μM SANGER
SK-HEP-1 Growth inhibition assay IC50 = 0.26712 μM SANGER
RPMI-8402 Growth inhibition assay IC50 = 0.27109 μM SANGER
H4 Growth inhibition assay IC50 = 0.29654 μM SANGER
LU-134-A Growth inhibition assay IC50 = 0.29919 μM SANGER
EoL-1-cell Growth inhibition assay IC50 = 0.30172 μM SANGER
SBC-5 Growth inhibition assay IC50 = 0.30262 μM SANGER
DEL Growth inhibition assay IC50 = 0.31149 μM SANGER
P12-ICHIKAWA Growth inhibition assay IC50 = 0.31679 μM SANGER
AGS Growth inhibition assay IC50 = 0.31823 μM SANGER
KS-1 Growth inhibition assay IC50 = 0.33444 μM SANGER
SK-PN-DW Growth inhibition assay IC50 = 0.34228 μM SANGER
DOHH-2 Growth inhibition assay IC50 = 0.34733 μM SANGER
KGN Growth inhibition assay IC50 = 0.35189 μM SANGER
A3-KAW Growth inhibition assay IC50 = 0.35826 μM SANGER
M059J Growth inhibition assay IC50 = 0.36401 μM SANGER
Daoy Growth inhibition assay IC50 = 0.36773 μM SANGER
MKN1 Growth inhibition assay IC50 = 0.38169 μM SANGER
CESS Growth inhibition assay IC50 = 0.38386 μM SANGER
SW620 Growth inhibition assay IC50 = 0.38448 μM SANGER
NCI-H1355 Growth inhibition assay IC50 = 0.38972 μM SANGER
EB2 Growth inhibition assay IC50 = 0.39146 μM SANGER
ABC-1 Growth inhibition assay IC50 = 0.40453 μM SANGER
GT3TKB Growth inhibition assay IC50 = 0.40644 μM SANGER
CTV-1 Growth inhibition assay IC50 = 0.40969 μM SANGER
VA-ES-BJ Growth inhibition assay IC50 = 0.41481 μM SANGER
KP-4 Growth inhibition assay IC50 = 0.41615 μM SANGER
MOLT-4 Growth inhibition assay IC50 = 0.41754 μM SANGER
NKM-1 Growth inhibition assay IC50 = 0.42516 μM SANGER
A2058 Growth inhibition assay IC50 = 0.42537 μM SANGER
BFTC-905 Growth inhibition assay IC50 = 0.42621 μM SANGER
SR Growth inhibition assay IC50 = 0.44265 μM SANGER
NCI-H526 Growth inhibition assay IC50 = 0.45612 μM SANGER
MES-SA Growth inhibition assay IC50 = 0.45821 μM SANGER
MHH-ES-1 Growth inhibition assay IC50 = 0.46271 μM SANGER
IMR-5 Growth inhibition assay IC50 = 0.46935 μM SANGER
RKO Growth inhibition assay IC50 = 0.47075 μM SANGER
HOS Growth inhibition assay IC50 = 0.47376 μM SANGER
647-V Growth inhibition assay IC50 = 0.48734 μM SANGER
786-0 Growth inhibition assay IC50 = 0.4922 μM SANGER
Calu-3 Growth inhibition assay IC50 = 0.49556 μM SANGER
U251 Growth inhibition assay IC50 = 0.50083 μM SANGER
23132-87 Growth inhibition assay IC50 = 0.50139 μM SANGER
BE-13 Growth inhibition assay IC50 = 0.50368 μM SANGER
SW1710 Growth inhibition assay IC50 = 0.51838 μM SANGER
ES4 Growth inhibition assay IC50 = 0.52145 μM SANGER
HOP-62 Growth inhibition assay IC50 = 0.52437 μM SANGER
MHH-NB-11 Growth inhibition assay IC50 = 0.52443 μM SANGER
KYSE-150 Growth inhibition assay IC50 = 0.53039 μM SANGER
ESS-1 Growth inhibition assay IC50 = 0.53078 μM SANGER
HLE Growth inhibition assay IC50 = 0.53357 μM SANGER
NEC8 Growth inhibition assay IC50 = 0.53895 μM SANGER
HC-1 Growth inhibition assay IC50 = 0.54032 μM SANGER
BC-1 Growth inhibition assay IC50 = 0.54533 μM SANGER
SK-LMS-1 Growth inhibition assay IC50 = 0.5528 μM SANGER
NCI-H2342 Growth inhibition assay IC50 = 0.55508 μM SANGER
OCI-AML2 Growth inhibition assay IC50 = 0.55935 μM SANGER
KYSE-510 Growth inhibition assay IC50 = 0.56639 μM SANGER
HMV-II Growth inhibition assay IC50 = 0.56879 μM SANGER
RPMI-2650 Growth inhibition assay IC50 = 0.57196 μM SANGER
DMS-273 Growth inhibition assay IC50 = 0.57348 μM SANGER
MC-CAR Growth inhibition assay IC50 = 0.57962 μM SANGER
DU-145 Growth inhibition assay IC50 = 0.59125 μM SANGER
HCC1599 Growth inhibition assay IC50 = 0.61627 μM SANGER
RT-112 Growth inhibition assay IC50 = 0.62053 μM SANGER
CAL-148 Growth inhibition assay IC50 = 0.62544 μM SANGER
ES3 Growth inhibition assay IC50 = 0.62849 μM SANGER
A375 Growth inhibition assay IC50 = 0.63084 μM SANGER
SW872 Growth inhibition assay IC50 = 0.6404 μM SANGER
LCLC-103H Growth inhibition assay IC50 = 0.6511 μM SANGER
MEL-JUSO Growth inhibition assay IC50 = 0.6571 μM SANGER
NH-12 Growth inhibition assay IC50 = 0.67198 μM SANGER
NCI-H187 Growth inhibition assay IC50 = 0.67362 μM SANGER
CAL-33 Growth inhibition assay IC50 = 0.6858 μM SANGER
ALL-PO Growth inhibition assay IC50 = 0.68979 μM SANGER
8505C Growth inhibition assay IC50 = 0.69275 μM SANGER
NCI-H2009 Growth inhibition assay IC50 = 0.69655 μM SANGER
KURAMOCHI Growth inhibition assay IC50 = 0.6986 μM SANGER
HSC-2 Growth inhibition assay IC50 = 0.70578 μM SANGER
SUP-T1 Growth inhibition assay IC50 = 0.70586 μM SANGER
GI-1 Growth inhibition assay IC50 = 0.71317 μM SANGER
TUR Growth inhibition assay IC50 = 0.72224 μM SANGER
PF-382 Growth inhibition assay IC50 = 0.72388 μM SANGER
MEL-HO Growth inhibition assay IC50 = 0.72874 μM SANGER
BCPAP Growth inhibition assay IC50 = 0.73695 μM SANGER
MFH-ino Growth inhibition assay IC50 = 0.7513 μM SANGER
ONS-76 Growth inhibition assay IC50 = 0.75429 μM SANGER
MFE-296 Growth inhibition assay IC50 = 0.76297 μM SANGER
NCI-H2087 Growth inhibition assay IC50 = 0.76306 μM SANGER
LCLC-97TM1 Growth inhibition assay IC50 = 0.76624 μM SANGER
ES7 Growth inhibition assay IC50 = 0.76713 μM SANGER
A431 Growth inhibition assay IC50 = 0.79754 μM SANGER
HCE-4 Growth inhibition assay IC50 = 0.80135 μM SANGER
SK-MES-1 Growth inhibition assay IC50 = 0.80842 μM SANGER
MZ1-PC Growth inhibition assay IC50 = 0.8111 μM SANGER
ME-180 Growth inhibition assay IC50 = 0.8238 μM SANGER
MCF7 Growth inhibition assay IC50 = 0.8305 μM SANGER
G-361 Growth inhibition assay IC50 = 0.83387 μM SANGER
ACHN Growth inhibition assay IC50 = 0.83874 μM SANGER
A4-Fuk Growth inhibition assay IC50 = 0.84103 μM SANGER
SCC-9 Growth inhibition assay IC50 = 0.84957 μM SANGER
IST-SL2 Growth inhibition assay IC50 = 0.85003 μM SANGER
CAL-62 Growth inhibition assay IC50 = 0.85117 μM SANGER
C-33-A Growth inhibition assay IC50 = 0.86169 μM SANGER
5637 Growth inhibition assay IC50 = 0.86693 μM SANGER
EFM-19 Growth inhibition assay IC50 = 0.86752 μM SANGER
SW48 Growth inhibition assay IC50 = 0.86895 μM SANGER
NCI-H748 Growth inhibition assay IC50 = 0.87069 μM SANGER
CHL-1 Growth inhibition assay IC50 = 0.8829 μM SANGER
G-402 Growth inhibition assay IC50 = 0.89819 μM SANGER
LS-411N Growth inhibition assay IC50 = 0.92538 μM SANGER
GCIY Growth inhibition assay IC50 = 0.92549 μM SANGER
HuO9 Growth inhibition assay IC50 = 0.92578 μM SANGER
BPH-1 Growth inhibition assay IC50 = 0.94282 μM SANGER
ECC12 Growth inhibition assay IC50 = 0.95438 μM SANGER
SU-DHL-1 Growth inhibition assay IC50 = 0.95915 μM SANGER
TE-15 Growth inhibition assay IC50 = 0.95964 μM SANGER
BB65-RCC Growth inhibition assay IC50 = 0.97887 μM SANGER
NUGC-3 Growth inhibition assay IC50 = 0.98081 μM SANGER
HCT-116 Growth inhibition assay IC50 = 1.00749 μM SANGER
639-V Growth inhibition assay IC50 = 1.00797 μM SANGER
RPMI-6666 Growth inhibition assay IC50 = 1.03221 μM SANGER
DoTc2-4510 Growth inhibition assay IC50 = 1.04831 μM SANGER
L-540 Growth inhibition assay IC50 = 1.05791 μM SANGER
NB12 Growth inhibition assay IC50 = 1.08357 μM SANGER
CAL-51 Growth inhibition assay IC50 = 1.08397 μM SANGER
NB69 Growth inhibition assay IC50 = 1.0875 μM SANGER
OVCAR-8 Growth inhibition assay IC50 = 1.09145 μM SANGER
A2780 Growth inhibition assay IC50 = 1.10527 μM SANGER
RL95-2 Growth inhibition assay IC50 = 1.11034 μM SANGER
HT-3 Growth inhibition assay IC50 = 1.12847 μM SANGER
UM-UC-3 Growth inhibition assay IC50 = 1.14554 μM SANGER
BFTC-909 Growth inhibition assay IC50 = 1.16148 μM SANGER
SNG-M Growth inhibition assay IC50 = 1.16368 μM SANGER
MG-63 Growth inhibition assay IC50 = 1.17999 μM SANGER
TE-5 Growth inhibition assay IC50 = 1.18327 μM SANGER
A101D Growth inhibition assay IC50 = 1.19812 μM SANGER
NCI-H209 Growth inhibition assay IC50 = 1.20699 μM SANGER
SCC-3 Growth inhibition assay IC50 = 1.21017 μM SANGER
P30-OHK Growth inhibition assay IC50 = 1.21124 μM SANGER
YKG-1 Growth inhibition assay IC50 = 1.22754 μM SANGER
CAPAN-1 Growth inhibition assay IC50 = 1.24645 μM SANGER
HCC2998 Growth inhibition assay IC50 = 1.25705 μM SANGER
HSC-4 Growth inhibition assay IC50 = 1.26252 μM SANGER
SAS Growth inhibition assay IC50 = 1.2672 μM SANGER
COR-L279 Growth inhibition assay IC50 = 1.26744 μM SANGER
FADU Growth inhibition assay IC50 = 1.28154 μM SANGER
SK-LU-1 Growth inhibition assay IC50 = 1.28962 μM SANGER
NCI-H1703 Growth inhibition assay IC50 = 1.29939 μM SANGER
KASUMI-1 Growth inhibition assay IC50 = 1.32239 μM SANGER
NCI-H1694 Growth inhibition assay IC50 = 1.37183 μM SANGER
LK-2 Growth inhibition assay IC50 = 1.40757 μM SANGER
CHP-212 Growth inhibition assay IC50 = 1.41096 μM SANGER
HSC-3 Growth inhibition assay IC50 = 1.43589 μM SANGER
G-401 Growth inhibition assay IC50 = 1.43693 μM SANGER
SF126 Growth inhibition assay IC50 = 1.44086 μM SANGER
HuP-T4 Growth inhibition assay IC50 = 1.45259 μM SANGER
EW-1 Growth inhibition assay IC50 = 1.45847 μM SANGER
MDA-MB-468 Growth inhibition assay IC50 = 1.46554 μM SANGER
NCI-H1734 Growth inhibition assay IC50 = 1.50503 μM SANGER
22RV1 Growth inhibition assay IC50 = 1.53054 μM SANGER
BHY Growth inhibition assay IC50 = 1.53169 μM SANGER
OVCAR-5 Growth inhibition assay IC50 = 1.53748 μM SANGER
EM-2 Growth inhibition assay IC50 = 1.57782 μM SANGER
NCI-H810 Growth inhibition assay IC50 = 1.58283 μM SANGER
IGR-1 Growth inhibition assay IC50 = 1.59112 μM SANGER
J-RT3-T3-5 Growth inhibition assay IC50 = 1.59438 μM SANGER
SF539 Growth inhibition assay IC50 = 1.60689 μM SANGER
GB-1 Growth inhibition assay IC50 = 1.60936 μM SANGER
SK-CO-1 Growth inhibition assay IC50 = 1.62804 μM SANGER
BOKU Growth inhibition assay IC50 = 1.63222 μM SANGER
PANC-03-27 Growth inhibition assay IC50 = 1.6369 μM SANGER
SF295 Growth inhibition assay IC50 = 1.65606 μM SANGER
COLO-668 Growth inhibition assay IC50 = 1.66431 μM SANGER
KM-H2 Growth inhibition assay IC50 = 1.66942 μM SANGER
C8166 Growth inhibition assay IC50 = 1.6773 μM SANGER
CTB-1 Growth inhibition assay IC50 = 1.68766 μM SANGER
NCI-H650 Growth inhibition assay IC50 = 1.70971 μM SANGER
C-4-II Growth inhibition assay IC50 = 1.71356 μM SANGER
NCI-H1650 Growth inhibition assay IC50 = 1.73565 μM SANGER
NCI-SNU-1 Growth inhibition assay IC50 = 1.75327 μM SANGER
SNU-423 Growth inhibition assay IC50 = 1.75342 μM SANGER
COLO-829 Growth inhibition assay IC50 = 1.76857 μM SANGER
SW13 Growth inhibition assay IC50 = 1.80203 μM SANGER
NCI-H2170 Growth inhibition assay IC50 = 1.85285 μM SANGER
MKN45 Growth inhibition assay IC50 = 1.87359 μM SANGER
KM12 Growth inhibition assay IC50 = 1.87938 μM SANGER
SN12C Growth inhibition assay IC50 = 1.88379 μM SANGER
SK-NEP-1 Growth inhibition assay IC50 = 1.90148 μM SANGER
HuCCT1 Growth inhibition assay IC50 = 1.91064 μM SANGER
SW954 Growth inhibition assay IC50 = 1.96311 μM SANGER
VMRC-RCZ Growth inhibition assay IC50 = 1.96786 μM SANGER
HT-29 Growth inhibition assay IC50 = 1.97537 μM SANGER
LB647-SCLC Growth inhibition assay IC50 = 2.00119 μM SANGER
KU812 Growth inhibition assay IC50 = 2.03197 μM SANGER
LoVo Growth inhibition assay IC50 = 2.06081 μM SANGER
LC-2-ad Growth inhibition assay IC50 = 2.06407 μM SANGER
KYSE-180 Growth inhibition assay IC50 = 2.06953 μM SANGER
NCI-H1299 Growth inhibition assay IC50 = 2.0703 μM SANGER
LXF-289 Growth inhibition assay IC50 = 2.07522 μM SANGER
BL-41 Growth inhibition assay IC50 = 2.08098 μM SANGER
COLO-800 Growth inhibition assay IC50 = 2.09855 μM SANGER
LB1047-RCC Growth inhibition assay IC50 = 2.13516 μM SANGER
OAW-28 Growth inhibition assay IC50 = 2.15234 μM SANGER
CAL-85-1 Growth inhibition assay IC50 = 2.15944 μM SANGER
A673 Growth inhibition assay IC50 = 2.16359 μM SANGER
MZ2-MEL Growth inhibition assay IC50 = 2.17939 μM SANGER
NOMO-1 Growth inhibition assay IC50 = 2.18798 μM SANGER
Ca9-22 Growth inhibition assay IC50 = 2.18807 μM SANGER
ARH-77 Growth inhibition assay IC50 = 2.18911 μM SANGER
D-283MED Growth inhibition assay IC50 = 2.19537 μM SANGER
AN3-CA Growth inhibition assay IC50 = 2.20226 μM SANGER
ST486 Growth inhibition assay IC50 = 2.24988 μM SANGER
SW1573 Growth inhibition assay IC50 = 2.25339 μM SANGER
769-P Growth inhibition assay IC50 = 2.25653 μM SANGER
HCC38 Growth inhibition assay IC50 = 2.27106 μM SANGER
RPMI-7951 Growth inhibition assay IC50 = 2.28584 μM SANGER
HL-60 Growth inhibition assay IC50 = 2.29181 μM SANGER
NCI-H1304 Growth inhibition assay IC50 = 2.30406 μM SANGER
8305C Growth inhibition assay IC50 = 2.32067 μM SANGER
Ca-Ski Growth inhibition assay IC50 = 2.32829 μM SANGER
DSH1 Growth inhibition assay IC50 = 2.36138 μM SANGER
HEC-1 Growth inhibition assay IC50 = 2.3745 μM SANGER
HO-1-N-1 Growth inhibition assay IC50 = 2.37868 μM SANGER
TE-10 Growth inhibition assay IC50 = 2.38102 μM SANGER
TYK-nu Growth inhibition assay IC50 = 2.41237 μM SANGER
LU-99A Growth inhibition assay IC50 = 2.42772 μM SANGER
NCI-H2405 Growth inhibition assay IC50 = 2.43564 μM SANGER
BC-3 Growth inhibition assay IC50 = 2.47545 μM SANGER
RERF-LC-MS Growth inhibition assay IC50 = 2.49413 μM SANGER
JiyoyeP-2003 Growth inhibition assay IC50 = 2.5428 μM SANGER
MKN28 Growth inhibition assay IC50 = 2.54669 μM SANGER
SF268 Growth inhibition assay IC50 = 2.54745 μM SANGER
HuH-7 Growth inhibition assay IC50 = 2.56377 μM SANGER
VM-CUB-1 Growth inhibition assay IC50 = 2.57875 μM SANGER
AU565 Growth inhibition assay IC50 = 2.61126 μM SANGER
GAMG Growth inhibition assay IC50 = 2.61355 μM SANGER
DBTRG-05MG Growth inhibition assay IC50 = 2.62832 μM SANGER
NCI-H2228 Growth inhibition assay IC50 = 2.65509 μM SANGER
MIA-PaCa-2 Growth inhibition assay IC50 = 2.6613 μM SANGER
NCI-H1882 Growth inhibition assay IC50 = 2.67868 μM SANGER
CMK Growth inhibition assay IC50 = 2.68446 μM SANGER
ETK-1 Growth inhibition assay IC50 = 2.74528 μM SANGER
NB13 Growth inhibition assay IC50 = 2.76358 μM SANGER
PANC-10-05 Growth inhibition assay IC50 = 2.88779 μM SANGER
UACC-62 Growth inhibition assay IC50 = 2.91997 μM SANGER
SW756 Growth inhibition assay IC50 = 2.98046 μM SANGER
SJSA-1 Growth inhibition assay IC50 = 2.98416 μM SANGER
L-428 Growth inhibition assay IC50 = 2.98894 μM SANGER
IST-MEL1 Growth inhibition assay IC50 = 2.99943 μM SANGER
JEG-3 Growth inhibition assay IC50 = 3.04067 μM SANGER
SW1783 Growth inhibition assay IC50 = 3.05871 μM SANGER
BHT-101 Growth inhibition assay IC50 = 3.10736 μM SANGER
SH-4 Growth inhibition assay IC50 = 3.1346 μM SANGER
NCI-H358 Growth inhibition assay IC50 = 3.15154 μM SANGER
LC4-1 Growth inhibition assay IC50 = 3.22759 μM SANGER
GCT Growth inhibition assay IC50 = 3.26576 μM SANGER
EGI-1 Growth inhibition assay IC50 = 3.27013 μM SANGER
NMC-G1 Growth inhibition assay IC50 = 3.32432 μM SANGER
A388 Growth inhibition assay IC50 = 3.32957 μM SANGER
J82 Growth inhibition assay IC50 = 3.33987 μM SANGER
NCI-H522 Growth inhibition assay IC50 = 3.35766 μM SANGER
EFO-27 Growth inhibition assay IC50 = 3.35777 μM SANGER
NCI-H1437 Growth inhibition assay IC50 = 3.38115 μM SANGER
MLMA Growth inhibition assay IC50 = 3.38191 μM SANGER
GDM-1 Growth inhibition assay IC50 = 3.40206 μM SANGER
IA-LM Growth inhibition assay IC50 = 3.43569 μM SANGER
no-10 Growth inhibition assay IC50 = 3.48873 μM SANGER
NOS-1 Growth inhibition assay IC50 = 3.58057 μM SANGER
HCC1569 Growth inhibition assay IC50 = 3.58372 μM SANGER
FTC-133 Growth inhibition assay IC50 = 3.58908 μM SANGER
AM-38 Growth inhibition assay IC50 = 3.66706 μM SANGER
KYSE-450 Growth inhibition assay IC50 = 3.68871 μM SANGER
ChaGo-K-1 Growth inhibition assay IC50 = 3.79409 μM SANGER
HAL-01 Growth inhibition assay IC50 = 3.80443 μM SANGER
NCI-H1770 Growth inhibition assay IC50 = 3.86539 μM SANGER
HEL Growth inhibition assay IC50 = 3.89764 μM SANGER
NCI-H64 Growth inhibition assay IC50 = 3.99787 μM SANGER
LU-139 Growth inhibition assay IC50 = 4.00867 μM SANGER
LS-123 Growth inhibition assay IC50 = 4.02035 μM SANGER
Calu-6 Growth inhibition assay IC50 = 4.05854 μM SANGER
KP-N-YS Growth inhibition assay IC50 = 4.23582 μM SANGER
MZ7-mel Growth inhibition assay IC50 = 4.29859 μM SANGER
KARPAS-422 Growth inhibition assay IC50 = 4.3292 μM SANGER
IPC-298 Growth inhibition assay IC50 = 4.33485 μM SANGER
NCI-H661 Growth inhibition assay IC50 = 4.34179 μM SANGER
WSU-NHL Growth inhibition assay IC50 = 4.36044 μM SANGER
HH Growth inhibition assay IC50 = 4.44423 μM SANGER
NY Growth inhibition assay IC50 = 4.48988 μM SANGER
BT-20 Growth inhibition assay IC50 = 4.5794 μM SANGER
NCI-H1417 Growth inhibition assay IC50 = 4.60594 μM SANGER
CAL-39 Growth inhibition assay IC50 = 4.63617 μM SANGER
RPMI-8866 Growth inhibition assay IC50 = 4.64882 μM SANGER
NCI-H292 Growth inhibition assay IC50 = 4.7095 μM SANGER
SJRH30 Growth inhibition assay IC50 = 4.72366 μM SANGER
HCC1806 Growth inhibition assay IC50 = 4.73101 μM SANGER
MEG-01 Growth inhibition assay IC50 = 4.74917 μM SANGER
EW-11 Growth inhibition assay IC50 = 4.76565 μM SANGER
RD Growth inhibition assay IC50 = 4.80409 μM SANGER
KYSE-140 Growth inhibition assay IC50 = 4.91746 μM SANGER
NCI-H2081 Growth inhibition assay IC50 = 4.91765 μM SANGER
HOP-92 Growth inhibition assay IC50 = 5.02277 μM SANGER
BV-173 Growth inhibition assay IC50 = 5.05329 μM SANGER
OE33 Growth inhibition assay IC50 = 5.12216 μM SANGER
NCI-H1793 Growth inhibition assay IC50 = 5.30922 μM SANGER
Daudi Growth inhibition assay IC50 = 5.36115 μM SANGER
NCI-H2122 Growth inhibition assay IC50 = 5.39424 μM SANGER
SW1990 Growth inhibition assay IC50 = 5.639 μM SANGER
MS-1 Growth inhibition assay IC50 = 5.64297 μM SANGER
HT-1376 Growth inhibition assay IC50 = 5.81886 μM SANGER
GP5d Growth inhibition assay IC50 = 5.8311 μM SANGER
OAW-42 Growth inhibition assay IC50 = 6.05896 μM SANGER
LB831-BLC Growth inhibition assay IC50 = 6.15047 μM SANGER
COR-L23 Growth inhibition assay IC50 = 6.18279 μM SANGER
CP66-MEL Growth inhibition assay IC50 = 6.25378 μM SANGER
CHP-126 Growth inhibition assay IC50 = 6.27397 μM SANGER
GOTO Growth inhibition assay IC50 = 6.37509 μM SANGER
DB Growth inhibition assay IC50 = 6.5298 μM SANGER
L-363 Growth inhibition assay IC50 = 6.58998 μM SANGER
SCC-25 Growth inhibition assay IC50 = 6.63406 μM SANGER
CAKI-1 Growth inhibition assay IC50 = 6.65287 μM SANGER
GR-ST Growth inhibition assay IC50 = 6.68733 μM SANGER
Mewo Growth inhibition assay IC50 = 6.79226 μM SANGER
MMAC-SF Growth inhibition assay IC50 = 6.87553 μM SANGER
CCF-STTG1 Growth inhibition assay IC50 = 6.91149 μM SANGER
NCI-H1563 Growth inhibition assay IC50 = 7.06829 μM SANGER
BL-70 Growth inhibition assay IC50 = 7.07066 μM SANGER
SCC-4 Growth inhibition assay IC50 = 7.20234 μM SANGER
TE-11 Growth inhibition assay IC50 = 7.45503 μM SANGER
TK10 Growth inhibition assay IC50 = 7.49225 μM SANGER
NCI-H2196 Growth inhibition assay IC50 = 7.49486 μM SANGER
no-11 Growth inhibition assay IC50 = 7.55794 μM SANGER
HuO-3N1 Growth inhibition assay IC50 = 7.71346 μM SANGER
HCT-15 Growth inhibition assay IC50 = 7.87059 μM SANGER
Calu-1 Growth inhibition assay IC50 = 7.89022 μM SANGER
NCI-SNU-5 Growth inhibition assay IC50 = 7.91903 μM SANGER
C3A Growth inhibition assay IC50 = 7.93051 μM SANGER
M14 Growth inhibition assay IC50 = 7.94538 μM SANGER
KMOE-2 Growth inhibition assay IC50 = 8.03697 μM SANGER
NCI-H520 Growth inhibition assay IC50 = 8.03907 μM SANGER
NCI-H69 Growth inhibition assay IC50 = 8.18234 μM SANGER
SK-MEL-30 Growth inhibition assay IC50 = 8.24405 μM SANGER
COLO-680N Growth inhibition assay IC50 = 8.25621 μM SANGER
Raji Growth inhibition assay IC50 = 8.31941 μM SANGER
NCI-H2141 Growth inhibition assay IC50 = 8.52227 μM SANGER
HD-MY-Z Growth inhibition assay IC50 = 8.53777 μM SANGER
CaR-1 Growth inhibition assay IC50 = 8.60091 μM SANGER
A172 Growth inhibition assay IC50 = 8.64964 μM SANGER
NCI-H510A Growth inhibition assay IC50 = 8.65064 μM SANGER
TE-8 Growth inhibition assay IC50 = 8.75118 μM SANGER
T98G Growth inhibition assay IC50 = 8.81581 μM SANGER
SIMA Growth inhibition assay IC50 = 8.85231 μM SANGER
SW626 Growth inhibition assay IC50 = 8.90372 μM SANGER
CAL-54 Growth inhibition assay IC50 = 8.92125 μM SANGER
MDA-MB-231 Growth inhibition assay IC50 = 9.08645 μM SANGER
NCI-H630 Growth inhibition assay IC50 = 9.12079 μM SANGER
LAMA-84 Growth inhibition assay IC50 = 9.20893 μM SANGER
COR-L105 Growth inhibition assay IC50 = 9.56953 μM SANGER
NCI-H2347 Growth inhibition assay IC50 = 9.66391 μM SANGER
SK-MM-2 Growth inhibition assay IC50 = 9.68223 μM SANGER
PC-14 Growth inhibition assay IC50 = 9.72234 μM SANGER
KG-1 Growth inhibition assay IC50 = 9.72465 μM SANGER
COLO-320-HSR Growth inhibition assay IC50 = 9.73489 μM SANGER
GI-ME-N Growth inhibition assay IC50 = 9.82616 μM SANGER
KMS-12-PE Growth inhibition assay IC50 = 9.91106 μM SANGER
Ramos-2G6-4C10 Growth inhibition assay IC50 = 9.93808 μM SANGER
HCC1954 Growth inhibition assay IC50 = 10.0429 μM SANGER
SK-MEL-3 Growth inhibition assay IC50 = 10.1322 μM SANGER
NB1 Growth inhibition assay IC50 = 10.2077 μM SANGER
KLE Growth inhibition assay IC50 = 10.2925 μM SANGER
KALS-1 Growth inhibition assay IC50 = 10.3029 μM SANGER
NCI-H2126 Growth inhibition assay IC50 = 10.3993 μM SANGER
CAL-27 Growth inhibition assay IC50 = 10.4443 μM SANGER
SK-OV-3 Growth inhibition assay IC50 = 10.8274 μM SANGER
SNB75 Growth inhibition assay IC50 = 10.9411 μM SANGER
NCI-H1155 Growth inhibition assay IC50 = 11.02 μM SANGER
Detroit562 Growth inhibition assay IC50 = 11.0755 μM SANGER
CAL-12T Growth inhibition assay IC50 = 11.136 μM SANGER
NCI-H226 Growth inhibition assay IC50 = 11.1518 μM SANGER
NCI-H441 Growth inhibition assay IC50 = 11.166 μM SANGER
OS-RC-2 Growth inhibition assay IC50 = 11.2175 μM SANGER
U031 Growth inhibition assay IC50 = 11.2885 μM SANGER
NCI-H2052 Growth inhibition assay IC50 = 11.4502 μM SANGER
TCCSUP Growth inhibition assay IC50 = 11.6187 μM SANGER
T47D Growth inhibition assay IC50 = 11.6637 μM SANGER
Becker Growth inhibition assay IC50 = 11.8156 μM SANGER
EFO-21 Growth inhibition assay IC50 = 11.8503 μM SANGER
NCI-H1963 Growth inhibition assay IC50 = 12.0942 μM SANGER
MONO-MAC-6 Growth inhibition assay IC50 = 12.1309 μM SANGER
MOLT-16 Growth inhibition assay IC50 = 12.4619 μM SANGER
U-698-M Growth inhibition assay IC50 = 12.4627 μM SANGER
MDA-MB-157 Growth inhibition assay IC50 = 12.6094 μM SANGER
KYSE-410 Growth inhibition assay IC50 = 12.8456 μM SANGER
CAMA-1 Growth inhibition assay IC50 = 13.0046 μM SANGER
SCC-15 Growth inhibition assay IC50 = 13.1497 μM SANGER
NCI-H23 Growth inhibition assay IC50 = 13.1861 μM SANGER
KNS-42 Growth inhibition assay IC50 = 13.6511 μM SANGER
HDLM-2 Growth inhibition assay IC50 = 13.7938 μM SANGER
NCI-H1623 Growth inhibition assay IC50 = 13.9776 μM SANGER
RPMI-8226 Growth inhibition assay IC50 = 14.3243 μM SANGER
EW-3 Growth inhibition assay IC50 = 14.3337 μM SANGER
HT Growth inhibition assay IC50 = 15.2889 μM SANGER
CAL-120 Growth inhibition assay IC50 = 15.6326 μM SANGER
HCC1937 Growth inhibition assay IC50 = 15.7725 μM SANGER
NCI-N87 Growth inhibition assay IC50 = 15.8106 μM SANGER
NB10 Growth inhibition assay IC50 = 15.9987 μM SANGER
UACC-812 Growth inhibition assay IC50 = 16.4249 μM SANGER
MHH-PREB-1 Growth inhibition assay IC50 = 16.4817 μM SANGER
SNU-449 Growth inhibition assay IC50 = 16.6657 μM SANGER
COLO-684 Growth inhibition assay IC50 = 16.7953 μM SANGER
BxPC-3 Growth inhibition assay IC50 = 16.8611 μM SANGER
DMS-153 Growth inhibition assay IC50 = 16.9246 μM SANGER
SW962 Growth inhibition assay IC50 = 16.9729 μM SANGER
OVCAR-4 Growth inhibition assay IC50 = 17.3428 μM SANGER
CAS-1 Growth inhibition assay IC50 = 17.5833 μM SANGER
HPAF-II Growth inhibition assay IC50 = 17.6767 μM SANGER
NCI-H838 Growth inhibition assay IC50 = 17.9844 μM SANGER
D-247MG Growth inhibition assay IC50 = 18.052 μM SANGER
T-24 Growth inhibition assay IC50 = 18.0868 μM SANGER
YT Growth inhibition assay IC50 = 18.2712 μM SANGER
NCI-H596 Growth inhibition assay IC50 = 18.2999 μM SANGER
CPC-N Growth inhibition assay IC50 = 18.426 μM SANGER
HN Growth inhibition assay IC50 = 18.5533 μM SANGER
KARPAS-299 Growth inhibition assay IC50 = 19.2708 μM SANGER
ES6 Growth inhibition assay IC50 = 19.6334 μM SANGER
IST-SL1 Growth inhibition assay IC50 = 19.8912 μM SANGER
LOXIMVI Growth inhibition assay IC50 = 19.9253 μM SANGER
U-266 Growth inhibition assay IC50 = 19.9794 μM SANGER
HCC2157 Growth inhibition assay IC50 = 20.3328 μM SANGER
MPP-89 Growth inhibition assay IC50 = 20.7595 μM SANGER
MDA-MB-361 Growth inhibition assay IC50 = 20.8051 μM SANGER
RCM-1 Growth inhibition assay IC50 = 20.9952 μM SANGER
SW780 Growth inhibition assay IC50 = 21.109 μM SANGER
SK-MEL-2 Growth inhibition assay IC50 = 21.2698 μM SANGER
TE-1 Growth inhibition assay IC50 = 21.4838 μM SANGER
NB5 Growth inhibition assay IC50 = 21.8618 μM SANGER
OVCAR-3 Growth inhibition assay IC50 = 22.2138 μM SANGER
LNCaP-Clone-FGC Growth inhibition assay IC50 = 23.5156 μM SANGER
KYSE-520 Growth inhibition assay IC50 = 24.0956 μM SANGER
UMC-11 Growth inhibition assay IC50 = 24.3195 μM SANGER
NCCIT Growth inhibition assay IC50 = 24.4842 μM SANGER
OPM-2 Growth inhibition assay IC50 = 24.6118 μM SANGER
GAK Growth inhibition assay IC50 = 25.1015 μM SANGER
PLC-PRF-5 Growth inhibition assay IC50 = 25.4198 μM SANGER
K5 Growth inhibition assay IC50 = 25.5192 μM SANGER
HT55 Growth inhibition assay IC50 = 25.82 μM SANGER
HT-1197 Growth inhibition assay IC50 = 25.8682 μM SANGER
Saos-2 Growth inhibition assay IC50 = 26.0963 μM SANGER
NCI-H1648 Growth inhibition assay IC50 = 26.3623 μM SANGER
NCI-H747 Growth inhibition assay IC50 = 27.2478 μM SANGER
U-87-MG Growth inhibition assay IC50 = 27.5565 μM SANGER
LU-165 Growth inhibition assay IC50 = 28.8005 μM SANGER
Caov-3 Growth inhibition assay IC50 = 29.2228 μM SANGER
MN-60 Growth inhibition assay IC50 = 29.5512 μM SANGER
TE-6 Growth inhibition assay IC50 = 29.723 μM SANGER
EHEB Growth inhibition assay IC50 = 30.3605 μM SANGER
SNU-C2B Growth inhibition assay IC50 = 30.4898 μM SANGER
YAPC Growth inhibition assay IC50 = 30.5644 μM SANGER
LU-65 Growth inhibition assay IC50 = 30.8083 μM SANGER
HTC-C3 Growth inhibition assay IC50 = 30.8175 μM SANGER
HuP-T3 Growth inhibition assay IC50 = 30.9157 μM SANGER
LB2241-RCC Growth inhibition assay IC50 = 31.1032 μM SANGER
SK-N-DZ Growth inhibition assay IC50 = 31.4228 μM SANGER
KYSE-70 Growth inhibition assay IC50 = 32.3637 μM SANGER
EW-18 Growth inhibition assay IC50 = 32.7339 μM SANGER
NCI-H1651 Growth inhibition assay IC50 = 32.7543 μM SANGER
LS-1034 Growth inhibition assay IC50 = 33.1173 μM SANGER
RXF393 Growth inhibition assay IC50 = 33.7866 μM SANGER
OMC-1 Growth inhibition assay IC50 = 36.8562 μM SANGER
OE19 Growth inhibition assay IC50 = 36.9759 μM SANGER
MHH-CALL-2 Growth inhibition assay IC50 = 37.3808 μM SANGER
BB49-HNC Growth inhibition assay IC50 = 37.3849 μM SANGER
A498 Growth inhibition assay IC50 = 37.4282 μM SANGER
NCI-H1581 Growth inhibition assay IC50 = 37.647 μM SANGER
LB996-RCC Growth inhibition assay IC50 = 38.6567 μM SANGER
SKG-IIIa Growth inhibition assay IC50 = 38.976 μM SANGER
SBC-1 Growth inhibition assay IC50 = 39.1276 μM SANGER
TE-441-T Growth inhibition assay IC50 = 39.1447 μM SANGER
KINGS-1 Growth inhibition assay IC50 = 39.2733 μM SANGER
NCI-H28 Growth inhibition assay IC50 = 39.4002 μM SANGER
NCI-H1618 Growth inhibition assay IC50 = 40.1041 μM SANGER
MFE-280 Growth inhibition assay IC50 = 40.5005 μM SANGER
EB-3 Growth inhibition assay IC50 = 40.6243 μM SANGER
IM-9 Growth inhibition assay IC50 = 41.6341 μM SANGER
DV-90 Growth inhibition assay IC50 = 41.9741 μM SANGER
NCI-H1792 Growth inhibition assay IC50 = 42.6858 μM SANGER
SNU-387 Growth inhibition assay IC50 = 43.2181 μM SANGER
HCC1395 Growth inhibition assay IC50 = 44.7953 μM SANGER
TGW Growth inhibition assay IC50 = 46.3289 μM SANGER
KY821 Growth inhibition assay IC50 = 47.0932 μM SANGER
ECC4 Growth inhibition assay IC50 = 48.0182 μM SANGER
KARPAS-45 Growth inhibition assay IC50 = 48.2359 μM SANGER
LB2518-MEL Growth inhibition assay IC50 = 48.5056 μM SANGER
COR-L88 Growth inhibition assay IC50 = 48.735 μM SANGER
COLO-741 Growth inhibition assay IC50 = 48.8966 μM SANGER
HCE-T Growth inhibition assay IC50 = 49.301 μM SANGER
NCI-H1755 Growth inhibition assay IC50 = 49.3468 μM SANGER
他の多くの細胞株試験データをご覧になる場合はこちらをクリックして下さい

生物活性

製品説明 Etoposide is a semisynthetic derivative of podophyllotoxin, which inhibits DNA synthesis via topoisomerase II inhibition activity which enhances double-strand and single-strand cleavage of DNA and reversibly inhibits repair by topoisomerase II binding. Etoposide induces autophagy, mitophagy and apoptosis.
Targets
Topo II [2]
(Cell-free assay)
In Vitro
In vitro

Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA, which induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle. [1] Etoposide inhibits the growth of murine angiosarcoma cell line (ISOS-1) in a 5 days-period with IC50 of 0.25 μg/mL. Cell growth of normal murine microvascular endothelial cells (mECs) is less sensitive to Etoposide with IC50 of 10 μg/mL). [2] Etoposide treated for 6 hr inhibits colonies of tetraploid variant of the human leukemic lymphoblast line CCRF-CEM with IC50 of 0.6 μM. [3] Etoposide treated for 2 hr inhibits growth of human pancreatic cancer cell line Y1, Y3, Y5, Y19, YM. YS, and YT with IC50s of 300 μg/mL, 300 μg/mL, 300 μg/mL, 91 μg/mL, 0.68 μg/mL, 300 μg/mL, 300 μg/mL, and 260 μg/mL, respectively. [4] Etoposide exposed for 1 hr inhibits growth of human glioma cell lines CL5, G142, G152, G111, and G5 with IC50 of 8, 9, 9.8, 10, and 15.8 μg/mL respectively for 12 days. Under same condition, the IC90 value is attained in cell lines CL5, G152, G142, and G111 at 26, 27, 32, and 33 μg/mL. Etoposide inhibition of topoisomerase II is homogeneous for each cell. The average inhibition rates are 15%, 21.8%, 31.8%, 41.5%, and 49.5% for 1, 2, 4, 8, and 16 μg Etoposide, respectively. [5]
Kinase Assay Topoisomerase II activity assay
Nuclear extracts are prepared, and nuclei are isolated. The activity of topoisomerase II is calculated from the percentage of decatenation obtained. Tritiated kinoplast DNA (KDNA 0.22 μg) is used as a substrate. Etoposide and topoisomerase II are incubated for 30 min at 37 ℃ and are stopped with 1% sodium dodecyl sulfate (SDS) and proteinase K (100 μg/mL). The percentages of decatenation and inhibition of topoisomerase II by Etoposide are obtained.
細胞実験 細胞株 Human glioma cell lines CL5
濃度 80 μg/mL
反応時間 1 hour
実験の流れ

After the Etoposide treatment, cells are removed from the dish with phosphate-buffered saline (PBS) containing 0.03% trypsin and 0.27 mM ethylenediaminetetraacetic acid (EDTA) and are diluted into culture dishes in appropriate numbers to yield between 20 and 200 colonies. After 12 days, cultures are fixed with methanol-acetic acid, stained with crystal violet, and scored for colonies containing more than 50 cells. The standard errors are typically less than 15% of the mean value unless otherwise stated.
実験結果図 Methods Biomarkers 結果図 PMID
Western blot p53 / p-p53 / Acetyl-p53 / TF-IIB p53 / p21 / c-Myc / PARP 23800173
Immunofluorescence YAP p53 pDNA-PKcs MDC1 γH2AX / pATM COX IV 27515249
Growth inhibition assay Cell viability 22615609
In Vivo
In Vivo

Etoposide administrated as a single agent is found to been ineffective in many xenografts growth, such as Heterotransplanted Hepatoblastoma NMHB1, and NMHB 2, [6] human neuroblastoma xenograft, [7] and human gastrointestinal cancer xenograft, [8] while the dose of 10 mg/kg i.p. Etoposide inhibits murine angiosarcoma cell ISOS-1 tumors in 36% of controls. [2] Etoposide induces tumor immunity in Lewis lung cancer. A single administration of 50 mg/kg Etoposide i.p., induces a 60% survival of C57B1/6 mice injected with Lewis lung cancer cell (3LL) over 60 days. About 40% of these surviving mice reject a subsequent challenge with 3LL, while none of control mice survive beyond 30 days. 3LL cells which have survived an 90% lethal concentration of Etoposide in vitro kill 75% of recipient mice, but 60% surviving mice reject challenge with 3LL. Splenocytes harvested from tumor rejecting mice protect naive mice injected with 3LL. [9]
動物実験 動物モデル Murine angiosarcoma xenografts ISOS-1
投与量 10 mg/kg
投与経路 i.p. every day for 5 days from day 7
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06393816 Not yet recruiting
Large Cell Neuroendocrine Carcinoma of the Lung
Centre Leon Berard|Groupe Français de Pneumo-Cancérologie
 May 2024 Phase 2
NCT06406465 Not yet recruiting
Carcinoma Neuroendocrine|Tumor Neuroendocrine|Tumors Neuroendocrine|Neuroendocrine; Carcinoma|Small Cell; Receptors
National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC)
 May 15 2024 Phase 2
NCT06086288 Not yet recruiting
Merkel Cell Carcinoma
Fondazione IRCCS Istituto Nazionale dei Tumori Milano
 November 2023 Phase 2

化学情報

分子量 588.56 化学式

C29H32O13
CAS No. 33419-42-0 SDF Download Etoposide SDFをダウンロードする
Smiles CC1OCC2C(O1)C(C(C(O2)OC3C4COC(=O)C4C(C5=CC6=C(C=C35)OCO6)C7=CC(=C(C(=C7)OC)O)OC)O)O
保管

In vitro
Batch:

DMSO : 100 mg/mL ( (169.9 mM)； 吸湿したDMSOは溶解度を減少させます。新しいDMSOをご使用ください。)

Water : Insoluble

Ethanol : Insoluble

モル濃度計算器

in vivo
Batch:

Add solvents to the product individually and in order.

投与溶液組成計算機

実験計算

モル濃度計算器

質量 濃度 体積 分子量

投与溶液組成計算機(クリア溶液)

ステップ１：実験データを入力してください。（実験操作によるロスを考慮し、動物数を1匹分多くして計算・調製することを推奨します）

mg/kg g μL 匹

ステップ２：投与溶媒の組成を入力してください。（ロット毎に適した溶解組成が異なる場合があります。詳細については弊社までお問い合わせください）

% DMSO % % Tween 80 % ddH2O
%DMSO %

計算結果：

投与溶媒濃度： mg/ml;

DMSOストック溶液調製方法： mg 試薬を μL DMSOに溶解する（濃度 mg/mL, 注：濃度が当該ロットのDMSO溶解度を超える場合はご連絡ください。 )

投与溶媒調製方法：Take μL DMSOストック溶液に μL PEG300，を加え、完全溶解後μL Tween 80，を加えて完全溶解させた後 μL ddH2O，を加え完全に溶解させます。

投与溶媒調製方法：μL DMSOストック溶液に μL Corn oil，を加え、完全溶解。

注意：１.ストック溶液に沈殿、混濁などがないことをご確認ください；
２.順番通りに溶剤を加えてください。次のステップに進む前に溶液に沈殿、混濁などがないことを確認してから加えてください。ボルテックス、ソニケーション、水浴加熱など物理的な方法で溶解を早めることは可能です。

技術サポート

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よくある質問（FAQ）

質問1:
Regarding the Etoposide S1225, do you have any data of the inhibition sepcificity of this product? It will inhibit other enzymes other than TOP2A?

回答
According to the available published data, the inhibition of Etoposide is specific to TOP2A. But there're also two papers showing that Etoposide could inhibit the p34cdc2 Kinase Activity: 1. http://cancerres.aacrjournals.org/content/52/7/1817.short ; 2. http://cancerres.aacrjournals.org/content/50/12/3761.short.

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