ホームページ DNA Damage/DNA Repair ADC Cytotoxin inhibitor - Topoisomerase inhibitor - Apoptosis related activator - MicroRNA inhibitor Camptothecin (CPT) For research use only.

Camptothecin (CPT)

別名：Campathecin, (S)-(+)-Camptothecin,NSC-100880

Camptothecin (CPT) is a specific inhibitor of DNA topoisomerase I (Topo I) with IC50 of 0.68 μM in a cell-free assay. Camptothecin induces apoptosis in cancer cells via microRNA-125b-mediated mitochondrial pathways. Phase 2.

Camptothecin (CPT)化学構造

CAS No. 7689-03-4

サイズ 価格(税別) 在庫状況
10mM (1mL in DMSO) JPY 29500 国内在庫あり
JPY 22000 国内在庫あり
JPY 37000 国内在庫あり
JPY 55500 国内在庫あり
JPY 85500 国内在庫なし(納期7~10日)

代表番号: 045-509-1970|電子メール：[email protected]
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文献中Selleckの製品使用例（143）

製品安全説明書

現在のバッチを見る： 純度： 99.79%
99.79

Camptothecin (CPT)関連製品

ADC Cytotoxin阻害剤の選択性比較

Cell Data

Cell Lines Assay Type Concentration Incubation Time 活性情報 PMID
HL60 Apoptosis assay 1 uM 6 hrs Induction of apoptosis in human HL60 cells assessed as nucleosomal DNA fragmentation at 1 uM after 6 hrs 17950603
HT-29 Cell cycle assay 0.1 uM 6 hrs Cell cycle distribution in human HT-29 cells assessed as accumulation at S phase at 0.1 uM after 6 hrs by flow cytometry 19715319
HT-29 Cell cycle assay 0.1 uM 12 hrs Cell cycle distribution in human HT-29 cells assessed as accumulation at S phase at 0.1 uM after 12 hrs by flow cytometry 19715319
HT-29 Cell cycle assay 0.1 uM 24 hrs Cell cycle distribution in human HT-29 cells assessed as accumulation at S phase at 0.1 uM after 24 hrs by flow cytometry 19715319
HT-29 Cell cycle assay 0.1 uM 48 hrs Cell cycle distribution in human HT-29 cells assessed as accumulation at S phase at 0.1 uM after 48 hrs by flow cytometry 19715319
HT-29 Cell cycle assay 0.1 uM 48 hrs Cell cycle distribution in human HT-29 cells assessed as accumulation at sub-G1 phase at 0.1 uM after 48 hrs by flow cytometry 19715319
U87MG Cytotoxicity assay 250 nM 6 days Cytotoxicity against human U87MG cells at 250 nM after 6 days 20655220
MOLT4 Cell cycle assay 5 uM 24 hrs Cell cycle arrest in human MOLT4 cells assessed as accumulation at sub G1 phase at 5 uM after 24 hrs using propidium iodide staining by flow cytometry 21074444
CHO Function assay 10 uM 30 mins Drug uptake in CHO cells at 10 uM after 30 mins by confocal microscopy 21282053
CHO Function assay 10 uM 30 mins Drug uptake in NK1R overexpressing CHO cells at 10 uM after 30 mins by confocal microscopy 21282053
HL60 Apoptosis assay 4 uM 9 hrs Induction of apoptosis in human HL60 cells assessed as DNA ladder formation at 4 uM after 9 hrs by agarose gel electrophoresis 21334793
SW620 Apoptosis assay 5 uM 6 hrs Induction of apoptosis in human SW620 cells assessed as DNA fragmentation at 5 uM after 6 hrs by gel electrophoresis 21620534
Jurkat T Apoptosis assay 2 uM 24 hrs Induction of apoptosis in human Jurkat T cells assessed as increase in phosphatidylserine level at 2 uM after 24 hrs by flow cytometric analysis 22200402
COLO205 Apoptosis assay 4 uM 24 hrs Induction of apoptosis in human COLO205 cells assessed as down regulation of Bcl-2 at 4 uM after 24 hrs by ELISA 22364746
HeLa Function assay 50 uM 6 hrs Inhibition of Mcl-1 in doxycyclin-stimulated human HeLa cells overexpressing Bad3SA assessed as increase in caspase3/7 activity at 50 uM after 6 hrs by luminescence analysis 22386982
HL60 Apoptosis assay 5 uM 6 hrs Induction of apoptosis in human HL60 cells assessed as DNA ladder formation at 5 uM after 6 hrs by DNA agarose gel electrophoresis 23584541
HCT116 Function assay 1 uM 1 hr Inhibition of human recombinant topoisomerase 1 in human HCT116 cells assessed as DNA-protein cross linking at 1 uM after 1 hr 24502276
HCT116 Function assay 1 uM 1 hr Inhibition of human recombinant topoisomerase 1 in human HCT116 cells assessed as DNA-protein cross linking at 1 uM incubated for 1 hr followed by compound washout measured after 1 hr 24502276
HCT116 Function assay 1 uM 1 hr Inhibition of human recombinant topoisomerase 1 in human HCT116 cells assessed as reversal of topoisomerase 1-DNA cleavage complex stabilization at 1 uM incubated for 1 hr followed by compound washout measured after 24 hrs by DNA immunoblotting analysis 24502276
HCT116 Function assay 1 uM 1 hr Inhibition of human recombinant topoisomerase 1 in human HCT116 cells assessed as reversal of topoisomerase 1-DNA cleavage complex stabilization at 1 uM incubated for 1 hr followed by compound washout measured up to 6 hrs by DNA immunoblotting analysis 24502276
HCT116 Function assay 1 uM 1 hr Inhibition of human recombinant topoisomerase 1 in human HCT116 cells assessed as stabilization of topoisomerase 1-DNA cleavage complex at 1 uM after 1 hr by DNA immunoblotting analysis 24502276
HeLa Apoptosis assay 0.8 to 1.6 uM 24 hrs Induction of apoptosis in human HeLa cells assessed as inhibition of DNA synthesis at 0.8 to 1.6 uM after 24 hrs by BrdU staining-based ELISA 24980118
MDA-MB-231 Apoptosis assay 0.8 to 1.6 uM 24 hrs Induction of apoptosis in human MDA-MB-231 cells assessed as inhibition of DNA synthesis at 0.8 to 1.6 uM after 24 hrs by BrdU staining-based ELISA 24980118
A375 Apoptosis assay 0.8 to 1.6 uM 24 hrs Induction of apoptosis in human A375 cells assessed as inhibition of DNA synthesis at 0.8 to 1.6 uM after 24 hrs by BrdU staining-based ELISA 24980118
Caco2 Apoptosis assay 0.8 to 1.6 uM 24 hrs Induction of apoptosis in human Caco2 cells assessed as inhibition of DNA synthesis at 0.8 to 1.6 uM after 24 hrs by BrdU staining-based ELISA 24980118
A549 Function assay 30 to 100 nM 30 mins Inhibition of topoisomerase 1 in human A549 cells assessed as reduction in relaxation of supercoiled DNA substrate at 30 to 100 nM incubated for 30 mins by ethidium bromide staining based gel electrophoresis 25003995
PC3 Apoptosis assay 2 uM 12 hrs Induction of apoptosis in human PC3 cells at 2 uM incubated for 12 hrs by DAPI staining based confocal laser microscopy 25176329
Sf9 Function assay 10 uM 5 mins Inhibition of wild type recombinant human Top1 expressed in baculovirus infected insect Sf9 cells assessed as decrease in supercoiled pBS(SK+) DNA isomer relaxation at 10 uM preincubated for 5 mins followed by pBS(SK+) DNA addition by agarose gel electrop 26312433
Sf9 Function assay 10 uM 30 mins Inhibition of wild type recombinant human Top1 expressed in baculovirus infected insect Sf9 cells assessed as decrease in supercoiled pBS(SK+) DNA isomer relaxation at 10 uM incubated simultaneously with enzyme and pBS(SK+) DNA for 30 mins by agarose gel 26312433
Sf9 Function assay 50 uM 30 mins Inhibition of wild type recombinant human Top1 expressed in baculovirus infected insect Sf9 cells assessed as stabilization of Top1-cleavage complexes at 50 uM incubated for 30 mins by agarose gel electrophoresis 26312433
HT-29 Function assay 2 uM 1 to 2 hrs Induction of DNA damage in human HT-29 cells assessed as gamma-H2AX foci formation at 2 uM after 1 to 2 hrs by DAPI staining based indirect immunofluorescence assay 26703795
HT-29 Function assay 2 uM 1 to 2 hrs Induction of DNA damage in human HT-29 cells assessed as increase in gamma-H2AX protein level at 2 uM after 1 to 2 hrs by Western blot analysis 26703795
H1299 Cytotoxicity assay up to 50 uM 24 hrs Cytotoxicity against human H1299 cells overexpressing alphavbeta3 integrin at up to 50 uM after 24 hrs by XTT assay 26719208
A549 Function assay 10 mM 12 to 24 hrs Drug uptake in human A549 cells at 10 mM after 12 to 24 hrs by flow cytometric method 27156772
A549 Function assay 10 mM 8 hrs Drug uptake in human A549 cells at 10 mM after 8 hrs by flow cytometric method 27156772
HCT116 Apoptosis assay 6.7 uM 18 hrs Induction of apoptosis in human HCT116 cells assessed as mitochondrial membrane permeability loss by measuring rhodamine 123 accumulation at 6.7 uM measured after 18 hrs by fluorescence inverted microscopic analysis 27721148
HCT116 Apoptosis assay 6.7 uM 18 hrs Induction of apoptosis in human HCT116 cells assessed as chromatin condensation at 6.7 uM measured after 18 hrs by Hoechst 33258 staining based fluorescence inverted microscopic analysis 27721148
HCT116 Apoptosis assay 6.7 uM 18 hrs Induction of apoptosis in human HCT116 cells assessed as appearance of half moon or crescent shape nuclei at 6.7 uM measured after 18 hrs by Hoechst 33258 staining based fluorescence inverted microscopic analysis 27721148
HCT116 Apoptosis assay 6.7 uM 18 hrs Induction of apoptosis in human HCT116 cells assessed as nuclear fragmentation at 6.7 uM measured after 18 hrs by Hoechst 33258 staining based fluorescence inverted microscopic analysis 27721148
HCT116 Apoptosis assay 6.7 uM 18 hrs Induction of apoptosis in human HCT116 cells assessed as formation of apoptotic bodies at 6.7 uM measured after 18 hrs by Hoechst 33258 staining based fluorescence inverted microscopic analysis 27721148
CCRF-CEM Cell cycle assay 0.01 uM 6 hrs Cell cycle arrest in human CCRF-CEM cells assessed as accumulation at S phase at 0.01 uM after 6 hrs by propidium iodide staining-based flow cytometry 28233677
CCRF-CEM Apoptosis assay 0.01 uM 72 hrs Induction of apoptosis in human CCRF-CEM cells at 0.01 uM after 72 hrs by propidium iodide staining-based flow cytometry 28233677
Bel7402 Function assay 1 uM 1 hr Poison activity at DNA topoisomerase 1 in human Bel7402 cells assessed as induction of DNA damage by measuring upregulated gamma-H2AX levels at 1 uM after 1 hr by Western blot analysis 28333459
Bel7402 Function assay 1 uM 1 hr Poison activity at DNA topoisomerase 1 in human Bel7402 cells assessed as induction of DNA damage by measuring upregulated levels of CHK1 phosphorylation at Ser345 residue at 1 uM after 1 hr by Western blot analysis 28333459
Bel7402 Function assay 1 nM 1 hr Poison activity at DNA topoisomerase 1 in human Bel7402 cells assessed as induction of DNA damage by measuring upregulated levels of CHK2 phosphorylation at Thr68 residue at 1 nM after 1 hr by Western blot analysis 28333459
CCRF-CEM Function assay 100 to 1000 nM 2 hrs Induction of DNA damage in human CCRF-CEM cells assessed as formation of gamma-H2AX foci at 100 to 1000 nM after 2 hrs by DAPI staining-based confocal microscopy 28418653
CCRF-CEM Function assay 0.1 to 1 uM 2 hrs Induction of DNA damage in human CCRF-CEM cells assessed as gamma-H2AX foci formation at 0.1 to 1 uM after 2 hrs by confocal microscopy 28657311
insect cells Function assay 80 uM 30 mins Inhibition of human topoisomerase-1 expressed in baculovirus infected insect cells at 80 uM using supercoiled pGEM-5Zf(+) plasmid DNA as substrate after 30 mins by agarose gel electrophoresis method 28753517
Sf9 Function assay 10 to 50 uM 30 mins Stabilization of recombinant human topoisomerase-1-supercoiled pBS SK(+) DNA cleavage complex at 10 to 50 uM after 30 mins using topoisomerase1 expressed in baculovirus infected cells by ethidium bromide staining based agarose gel electrophoresis meth 29290109
MCF7 Function assay 10 uM 12 hrs Stabilization of topoisomerase-1- genomic DNA cleavage complex in human MCF7 cells at 10 uM after 12 hrs by ICE assay 29290109
A549 Function assay 2 uM 2 hrs Induction of DNA damage in human A549 cells assessed as gamma-H2AX foci formation at 2 uM after 2 hrs by DAPI staining based immunofluorescence assay 29843103
A549 Function assay 2 uM 2 hrs Induction of DNA damage in human A549 cells assessed as increase in gamma-H2AX level at 2 uM after 2 hrs by immunoblot analysis 29843103
A549 Function assay 2 uM 2 hrs Induction of DNA damage in human A549 cells assessed as increase in CHK1 phosphorylation level at 2 uM after 2 hrs by immunoblot analysis 29843103
HCT116 Antimigratory assay 2 uM 96 hrs Antimigratory activity in human HCT116 cells at 2 uM after 96 hrs by wound healing assay 30340899
Sf9 Function assay 10 to 25 uM 30 mins Poison activity at recombinant human TOP1 expressed in baculovirus infected Sf9 insect cells assessed as stabilization of enzyme-pBS(SK+) DNA cleavable complex formation at 10 to 25 uM measured after 30 mins by ethidium bromide staining based agarose gel 30897325
Sf9 Function assay 5 to 25 uM 30 mins Poison activity at recombinant human TOP1 expressed in baculovirus infected Sf9 insect cells assessed as stabilization of enzyme-25mer duplex oligonucleotide cleavable complex formation at 5 to 25 uM measured after 30 mins by ethidium bromide staining bas 30897325
HCT116 Function assay 25 uM 1 hr Inhibition of TOP1 in human HCT116 cells assessed as induction of cellular TOP1cc formation at 25 uM incubated for 1 hr by chemiluminescence based assay 31176097
HCT116 Function assay 1 uM 3 hrs Inhibition of TOP1 in human HCT116 cells assessed as induction of DNA damage by measuring increase in gammaH2AX foci at 1 uM incubated for 3 hrs by DAPI staining based immunofluorescence microscopic method 31176097
MCF7 Function assay 10 uM 12 hrs Poisoning activity at topoisomerase 1 in human MCF7 cells at 10 uM after 12 hrs by immunoband depletion assay ChEMBL
MDA-MB-231 Cell cycle assay 1 uM 16 hrs Cell cycle arrest in human MDA-MB-231 cells assessed as accumulation at S-phase at 1 uM incubated for 16 hrs by flow cytometry ChEMBL
IMR-32 cytotoxicity assay ~10 μM IC50=2.21 nM 12617894
Col2 cytotoxicity assay ~1 μM ED50=57 nM 15043407
HUVEC cytotoxicity assay ~1 μM ED50=258 nM 15043407
KB cytotoxicity assay ~1 μM ED50=22 nM 15043407
LCNaP cytotoxicity assay ~1 μM ED50=28 nM 15043407
Lu1 cytotoxicity assay ~1 μM ED50=29 nM 15043407
RPMI8402 cytotoxicity assay ~10 μM IC50=6 nM 15482929
CPT-K5 cytotoxicity assay ~10 μM IC50>10 μM 15482929
P388 cytotoxicity assay ~10 μM IC50=14 nM 15482929
P388/CPT45 cytotoxicity assay ~10 μM IC50>10 μM 15482929
KB3-1 cytotoxicity assay ~10 μM IC50=40 nM 15482929
KBV-1 + MDR1 cytotoxicity assay ~10 μM IC50=440 nM 15482929
KBH cytotoxicity assay ~10 μM IC50=440 nM 15482929
HOP-62 cytotoxicity assay ~10 μM GI50=10 nM 15509164
HCT-116 cytotoxicity assay ~10 μM GI50=30 nM 15509164
F-539 cytotoxicity assay ~10 μM GI50=10 nM 15509164
UACC-62 cytotoxicity assay ~10 μM GI50=10 nM 15509164
OVCAR-3 cytotoxicity assay ~10 μM GI50=220 nM 15509164
SN12C cytotoxicity assay ~10 μM GI50=20 nM 15509164
DU-145 cytotoxicity assay ~10 μM GI50=10 nM 15509164
MDA-MB-435 cytotoxicity assay ~10 μM GI50=40 nM 15509164
A427 Growth inhibitory assay ~1 μM IC50=24 nM 9876111
PC-3 Growth inhibitory assay ~1 μM IC50=57 nM 9876111
K562adr Growth inhibitory assay ~1 μM IC50=57 nM 9876111
MCF7mdr Growth inhibitory assay ~1 μM IC50=3.1 nM 9876111
HT29 Apoptosis assay 5 uM Induction of apoptosis in human HT29 cells at 5 uM 17512744
U937 Antiproliferative assay 72 hrs Antiproliferative activity against human U937 cells after 72 hrs by WST-8 assay, IC50=0.015μM. 17158054
U937 Antiproliferative assay 48 hrs Antiproliferative activity against human U937 cells after 48 hrs by WST-8 assay, IC50=0.032μM. 17158054
U937 Antiproliferative assay 24 hrs Antiproliferative activity against human U937 cells after 24 hrs by WST-8 assay, IC50=0.68μM. 17158054
K562 Growth inhibition assay 5 days Growth inhibition of K562 cells by XTT assay after 5 days, IC50=0.04μM. 17411092
MCF7 Growth inhibition assay 4 days Growth inhibition of adriamycin-resistant MCF7 cells after 4 days, GI50=0.01μM. 17418582
HeLa Growth inhibition assay 4 days Growth inhibition of HeLa cells after 4 days, GI50=0.01μM. 17418582
MCF7 Growth inhibition assay 4 days Growth inhibition of MCF7 cells after 4 days, GI50=0.01μM. 17418582
P388 Cytotoxicity assay 72 hrs Cytotoxicity against mouse P388 cells after 72 hrs, IC50=0.0321μM. 17624792
A549 Cytotoxicity assay 48 hrs Cytotoxicity against human A549 cells after 48 hrs, IC50=0.004μM. 17673337
SK-OV3 Cytotoxicity assay 48 hrs Cytotoxicity against human SK-OV3 cells after 48 hrs, IC50=0.014μM. 17673337
HCT15 Cytotoxicity assay 48 hrs Cytotoxicity against human HCT15 cells after 48 hrs, IC50=0.083μM. 17673337
SK-MEL-2 Cytotoxicity assay 48 hrs Cytotoxicity against human SK-MEL-2 cells after 48 hrs, IC50=0.165μM. 17673337
HL60 Cytotoxicity assay 48 hrs Cytotoxicity against human HL60 cells after 48 hrs by MTT assay, GI50=0.0017μM. 17962028
Jurkat Growth inhibition assay 96 hrs Growth inhibition of human Jurkat cells after 96 hrs, IC50=0.0014μM. 18061452
K562 Cytotoxicity assay 5 days Cytotoxicity against human K562 cells after 5 days by XTT assay, IC50=0.04μM. 18076140
A2780 Cytotoxicity assay 96 hrs Cytotoxicity against human A2780 cells after 96 hrs by MTT assay, IC50=0.28μM. 18095653
A549 Cytotoxicity assay 96 hrs Cytotoxicity against human A549 cells after 96 hrs by MTT assay, IC50=3.12μM. 18095653
HCT8 Cytotoxicity assay 96 hrs Cytotoxicity against human HCT8 cells after 96 hrs by MTT assay, IC50=3.15μM. 18095653
BGC823 Cytotoxicity assay 96 hrs Cytotoxicity against human BGC823 cells after 96 hrs by MTT assay, IC50=9.67μM. 18095653
Bel7402 Cytotoxicity assay 96 hrs Cytotoxicity against human Bel7402 cells after 96 hrs by MTT assay, IC50=12.5μM. 18095653
PC3 Antiproliferative assay 48 hrs Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay, GI50=0.09μM. 18180162
HeLa Antiproliferative assay 48 hrs Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay, GI50=0.18μM. 18180162
SKHep Antiproliferative assay 48 hrs Antiproliferative activity against human SKHep cells after 48 hrs by MTT assay, GI50=0.22μM. 18180162
A549 Antiproliferative assay 48 hrs Antiproliferative activity against human A549 cells after 48 hrs by MTT assay, GI50=2.8μM. 18180162
SAS Antiproliferative assay 48 hrs Antiproliferative activity against human SAS cells after 48 hrs by MTT assay, GI50=6μM. 18180162
AGS Antiproliferative assay 48 hrs Antiproliferative activity against human AGS cells after 48 hrs by MTT assay, GI50=23.76μM. 18180162
H460 Cytotoxicity assay 72 hrs Cytotoxicity against human H460 cells after 72 hrs, IC50=0.0062μM. 18419110
IGROV1 Cytotoxicity assay 72 hrs Cytotoxicity against human IGROV1 cells after 72 hrs, IC50=0.012μM. 18419110
H460 Cytotoxicity assay 1 hr Cytotoxicity against human H460 cells after 1 hr, IC50=0.33μM. 18419110
IGROV1 Cytotoxicity assay 1 hr Cytotoxicity against human IGROV1 cells after 1 hr, IC50=1.65μM. 18419110
HT29 Cytotoxicity assay 1 hr Cytotoxicity against human HT29 cells after 1 hr, IC50=3.16μM. 18419110
HT29 Cytotoxicity assay 1 hr Cytotoxicity against human mitoxantrone-resistant HT29 cells after 1 hr, IC50=8.81μM. 18419110
H460 Antiproliferative assay 1 hr Antiproliferative activity against human H460 cells after 1 hr of drug exposure measured after 72 hrs, IC50=0.18μM. 18424133
HT29 Antiproliferative assay 1 hr Antiproliferative activity against human HT29 cells after 1 hr of drug exposure measured after 72 hrs, IC50=3.16μM. 18424133
HT29 Antiproliferative assay 1 hr Antiproliferative activity against BCRP overexpressing mitoxantrone-resistant human HT29 cells after 1 hr of drug exposure measured after 72 hrs, IC50=8.81μM. 18424133
KB Cytotoxicity assay 4 days Cytotoxicity against human KB cells after 4 days by MTT assay, IC50=0.003μM. 18554906
A549 Cytotoxicity assay 4 days Cytotoxicity against human A549 cells after 4 days by MTT assay, IC50=0.01μM. 18554906
HT29 Cytotoxicity assay 4 days Cytotoxicity against human HT29 cells after 4 days by MTT assay, IC50=0.09μM. 18554906
HepG2 Cytotoxicity assay 4 days Cytotoxicity against human HepG2 cells after 4 days by MTT assay, IC50=0.13μM. 18554906
BEL-7402 Cytotoxicity assay 4 days Cytotoxicity against human BEL-7402 cells after 4 days by MTT assay, IC50=0.17μM. 18554906
MCF7 Cytotoxicity assay 4 days Cytotoxicity against human MCF7 cells after 4 days by MTT assay, IC50=0.2μM. 18554906
A2780 Cytotoxicity assay 4 days Cytotoxicity against human A2780 cells after 4 days by MTT assay, IC50=0.2μM. 18554906
BXPC3 Cytotoxicity assay 4 days Cytotoxicity against human BXPC3 cells after 4 days by MTT assay, IC50=0.24μM. 18554906
NCI446 Cytotoxicity assay 4 days Cytotoxicity against human NCI446 cells after 4 days by MTT assay, IC50=3.28μM. 18554906
RPMI8402 Cytotoxicity assay 4 days Cytotoxicity against human RPMI8402 cells after 4 days by MTT assay, IC50=0.005μM. 18676151
P388 Cytotoxicity assay 4 days Cytotoxicity against mouse P388 cells after 4 days by MTT assay, IC50=0.009μM. 18676151
KB3-1 Cytotoxicity assay 4 days Cytotoxicity against human KB3-1 cells after 4 days by MTT assay, IC50=0.015μM. 18676151
KBV1 Cytotoxicity assay 4 days Cytotoxicity against human multidrug resistant MDR1 overexpressing human KBV1 cells after 4 days by MTT assay, IC50=0.025μM. 18676151
KBH5.0 Cytotoxicity assay 4 days Cytotoxicity against human multidrug resistant BCRP overexpressing human KBH5.0 cells after 4 days by MTT assay, IC50=0.026μM. 18676151
CCRF-CEM Cytotoxicity assay 3 days Cytotoxicity against p38-proficient human CCRF-CEM cells after 3 days by MTT assay, IC50=0.04μM. 19203291
A2780 Cytotoxicity assay 96 hrs Cytotoxicity against human A2780 cells after 96 hrs by MTT assay, IC50=0.3μM. 19256478
A549 Cytotoxicity assay 96 hrs Cytotoxicity against human A549 cells after 96 hrs by MTT assay, IC50=3.1μM. 19256478
HCT8 Cytotoxicity assay 96 hrs Cytotoxicity against human HCT8 cells after 96 hrs by MTT assay, IC50=3.2μM. 19256478
BGC823 Cytotoxicity assay 96 hrs Cytotoxicity against human BGC823 cells after 96 hrs by MTT assay, IC50=9.7μM. 19256478
Bel7402 Cytotoxicity assay 96 hrs Cytotoxicity against human Bel7402 cells after 96 hrs by MTT assay, IC50=12.5μM. 19256478
P388 Cytotoxicity assay 4 days Cytotoxicity against mouse P388 cells after 4 days by MTT assay, IC50=0.004μM. 19299037
RPMI8402 Cytotoxicity assay 4 days Cytotoxicity against human RPMI8402 cells after 4 days by MTT assay, IC50=0.004μM. 19299037
P388 Cytotoxicity assay 4 days Cytotoxicity against mouse P388 cells after 4 days by MTT method, IC50=0.004μM. 19303306
RPMI8402 Cytotoxicity assay 4 days Cytotoxicity against human RPMI8402 cells after 4 days by MTT method, IC50=0.004μM. 19303306
A2780 Cytotoxicity assay 96 hrs Cytotoxicity against human A2780 cells after 96 hrs by MTT assay, IC50=0.28μM. 19453174
NCI-H460 Antiproliferative assay 1 hr Antiproliferative activity against human NCI-H460 cells after short term exposure for 1 hr measured after 72 hrs in drug-free medium, IC50=0.33μM. 19530720
HCT116 Cytotoxicity assay 72 hrs Cytotoxicity against human HCT116 cells after 72 hrs by MTS assay, IC50=0.002μM. 19655762
MCF7 Cytotoxicity assay 72 hrs Cytotoxicity against human MCF7 cells expressing P-glycoprotein after 72 hrs by MTS assay, IC50=0.003μM. 19655762
HCT15 Cytotoxicity assay 72 hrs Cytotoxicity against human HCT15 cells after 72 hrs by MTS assay, IC50=0.003μM. 19655762
HL60 Cytotoxicity assay 72 hrs Cytotoxicity against human HL60 cells after 72 hrs by MTS assay, IC50=0.006μM. 19655762
MCF7 Cytotoxicity assay 72 hrs Cytotoxicity against human MCF7 cells after 72 hrs by MTS assay, IC50=0.01μM. 19655762
KB Cytotoxicity assay 72 hrs Cytotoxicity against human KB cells after 72 hrs by MTS assay, IC50=0.038μM. 19655762
HepG2 Cytotoxicity assay 72 hrs Cytotoxicity against human HepG2 cells after 72 hrs by MTS assay, IC50=0.455μM. 19655762
SW1573 Growth inhibition assay 48 hrs Growth inhibition of human SW1573 cells after 48 hrs by sulforhodamine B assay, GI50=0.21μM. 19664930
HBL100 Growth inhibition assay 48 hrs Growth inhibition of human HBL100 cells after 48 hrs by sulforhodamine B assay, GI50=0.23μM. 19664930
A2780 Growth inhibition assay 48 hrs Growth inhibition of human A2780 cells after 48 hrs by sulforhodamine B assay, GI50=0.46μM. 19664930
HeLa Growth inhibition assay 48 hrs Growth inhibition of human HeLa cells after 48 hrs by sulforhodamine B assay, GI50=1.3μM. 19664930
WiDr Growth inhibition assay 48 hrs Growth inhibition of human WiDr cells after 48 hrs by sulforhodamine B assay, GI50=1.7μM. 19664930
T47D Growth inhibition assay 48 hrs Growth inhibition of human T47D cells after 48 hrs by sulforhodamine B assay, GI50=1.9μM. 19664930
HCT116 Antiproliferative assay 3 days Antiproliferative activity against human HCT116 cells after 3 days by XTT assay, IC50=0.13μM. 19691293
SW948 Antiproliferative assay 3 days Antiproliferative activity against human SW948 cells after 3 days by XTT assay, IC50=0.16μM. 19691293
A2780 Cytotoxicity assay 4 days Cytotoxicity against human A2780 cells after 4 days by MTT assay, IC50=0.3μM. 19702283
A549 Cytotoxicity assay 48 hrs Cytotoxicity against human A549 cells expressing wild type p53 after 48 hrs by SRB assay, GI50=0.01μM. 19715319
AGS Cytotoxicity assay 48 hrs Cytotoxicity against human AGS cells expressing wild type p53 after 48 hrs by SRB assay, GI50=0.01μM. 19715319
MCF7 Cytotoxicity assay 48 hrs Cytotoxicity against estrogen receptor-positive human MCF7 cells expressing wild type p53 after 48 hrs by SRB assay, GI50=0.01μM. 19715319
Hep3B Cytotoxicity assay 48 hrs Cytotoxicity against p53-deficient human Hep3B cells after 48 hrs by SRB assay, GI50=0.01μM. 19715319
AGS Cytotoxicity assay 48 hrs Cytotoxicity against human AGS cells expressing wild type p53 after 48 hrs by SRB assay, IC50=0.02μM. 19715319
HT-29 Cytotoxicity assay 48 hrs Cytotoxicity against human HT-29 cells expressing p53 mutant after 48 hrs by SRB assay, GI50=0.03μM. 19715319
A549 Cytotoxicity assay 48 hrs Cytotoxicity against human A549 cells expressing wild type p53 after 48 hrs by SRB assay, IC50=0.04μM. 19715319
HeLa Cytotoxicity assay 48 hrs Cytotoxicity against p53-deficient human HeLa cells after 48 hrs by SRB assay, GI50=0.04μM. 19715319
Hep3B Cytotoxicity assay 48 hrs Cytotoxicity against p53-deficient human Hep3B cells after 48 hrs by SRB assay, IC50=0.06μM. 19715319
MDA-MB-261 Cytotoxicity assay 48 hrs Cytotoxicity against estrogen receptor-negative human MDA-MB-261 cells expressing p53 mutant after 48 hrs by SRB assay, GI50=0.08μM. 19715319
HepG2 Cytotoxicity assay 48 hrs Cytotoxicity against human HepG2 cells expressing wild type p53 after 48 hrs by SRB assay, GI50=0.1μM. 19715319
HepG2 Cytotoxicity assay 48 hrs Cytotoxicity against human HepG2 cells expressing wild type p53 after 48 hrs by SRB assay, IC50=0.2μM. 19715319
HeLa Cytotoxicity assay 48 hrs Cytotoxicity against p53-deficient human HeLa cells after 48 hrs by SRB assay, IC50=0.2μM. 19715319
U937 Cytotoxicity assay 48 hrs Cytotoxicity against human U937 cells expressing p53 mutant after 48 hrs by SRB assay, IC50=0.3μM. 19715319
HT-29 Cytotoxicity assay 48 hrs Cytotoxicity against human HT-29 cells expressing p53 mutant after 48 hrs by SRB assay, IC50=0.4μM. 19715319
THP1 Cytotoxicity assay 48 hrs Cytotoxicity against human THP1 cells expressing p53 mutant after 48 hrs by SRB assay, IC50=0.6μM. 19715319
PC3 Cytotoxicity assay 48 hrs Cytotoxicity against p53-deficient human PC3 cells after 48 hrs by SRB assay, GI50=0.7μM. 19715319
MCF7 Cytotoxicity assay 48 hrs Cytotoxicity against estrogen receptor-positive human MCF7 cells expressing wild type p53 after 48 hrs by SRB assay, IC50=1.1μM. 19715319
PC3 Cytotoxicity assay 48 hrs Cytotoxicity against p53-deficient human PC3 cells after 48 hrs by SRB assay, IC50=1.4μM. 19715319
K562 Cytotoxicity assay 48 hrs Cytotoxicity against p53-deficient human K562 cells after 48 hrs by SRB assay, IC50=1.4μM. 19715319
MDA-MB-261 Cytotoxicity assay 48 hrs Cytotoxicity against estrogen receptor-negative human MDA-MB-261 cells expressing p53 mutant after 48 hrs by SRB assay, IC50=1.7μM. 19715319
CCRF-CEM Cytotoxicity assay 48 hrs Cytotoxicity against human CCRF-CEM cells after 48 hrs by cell titer-blue assay, GI50=0.000023μM. 19743858
CCRF-CEM/C2 Cytotoxicity assay 48 hrs Cytotoxicity against human CCRF-CEM/C2 cells after 48 hrs by cell titer-blue assay, GI50=0.04321μM. 19743858
MCF7 Cytotoxicity assay 4 days Cytotoxicity against human MCF7 cells after 4 days by ELISA reader assay, IC50=0.06μM. 19939682
K562 Cytotoxicity assay 4 days Cytotoxicity against human K562 cells after 4 days by ELISA reader assay, IC50=0.08μM. 19939682
HeLa Cytotoxicity assay 4 days Cytotoxicity against human HeLa cells after 4 days by ELISA reader assay, IC50=0.63μM. 19939682
DU145 Cytotoxicity assay 4 days Cytotoxicity against human DU145 cells after 4 days by ELISA reader assay, IC50=0.66μM. 19939682
HCT15 Cytotoxicity assay 4 days Cytotoxicity against human HCT15 cells after 4 days by ELISA reader assay, IC50=0.76μM. 19939682
MDA-MB-231 Cytotoxicity assay 3 days Cytotoxicity against human MDA-MB-231 cells after 3 days, IC50=1.1μM. 19954977
DU145 Cytotoxicity assay 3 days Cytotoxicity against human DU145 cells after 3 days, IC50=1.46μM. 19954977
HeLa Cytotoxicity assay 3 days Cytotoxicity against human HeLa cells after 3 days, IC50=1.85μM. 19954977
HCT116 Cytotoxicity assay 3 days Cytotoxicity against human HCT116 cells after 3 days, IC50=2.77μM. 19954977
MCF7 Cytotoxicity assay 3 days Cytotoxicity against human MCF7 cells after 3 days, IC50=7.42μM. 19954977
A549 Cytotoxicity assay 48 hrs Cytotoxicity against human A549 cells after 48 hrs by MTT method, IC50=0.005379μM. 20063889
HL60 Cytotoxicity assay 48 hrs Cytotoxicity against human HL60 cells after 48 hrs by MTT assay, IC50=0.065μM. 20093033
HT-29 Cytotoxicity assay 48 hrs Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay, IC50=0.85μM. 20093033
HeLa Cytotoxicity assay 48 hrs Cytotoxicity against human HeLa cells after 48 hrs by MTT assay, IC50=0.86μM. 20093033
MDA-MB-231 Cytotoxicity assay 48 hrs Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay, IC50=0.92μM. 20093033
DU145 Cytotoxicity assay 48 hrs Cytotoxicity against human DU145 cells after 48 hrs by MTT assay, IC50=3.57μM. 20093033
THP1 Cytotoxicity assay 72 hrs Cytotoxicity against human THP1 cells after 72 hrs by erythosin B staining method, EC50=0.16μM. 20192247
KB Cytotoxicity assay 3 days Cytotoxicity against human KB cells after 3 days by MTT assay, IC50<0.013μM. 20392545
HCT8 Cytotoxicity assay 3 days Cytotoxicity against human HCT8 cells after 3 days by MTT assay, IC50<0.013μM. 20392545
MCF7 Cytotoxicity assay 3 days Cytotoxicity against human MCF7 cells after 3 days by MTT assay, IC50=0.02μM. 20392545
HL60 Cytotoxicity assay 2 days Cytotoxicity against human HL60 cells after 2 days by automatic ELISA reader system, IC50=0.1μM. 20392646
MDA-MB-231 Cytotoxicity assay 2 days Cytotoxicity against human MDA-MB-231 cells after 2 days by automatic ELISA reader system, IC50=0.3μM. 20392646
HeLa Cytotoxicity assay 2 days Cytotoxicity against human HeLa cells after 2 days by automatic ELISA reader system, IC50=0.4μM. 20392646
DU145 Cytotoxicity assay 2 days Cytotoxicity against human DU145 cells after 2 days by automatic ELISA reader system, IC50=0.4μM. 20392646
HCT15 Cytotoxicity assay 2 days Cytotoxicity against human HCT15 cells after 2 days by automatic ELISA reader system, IC50=0.5μM. 20392646
SKBR3 Antiproliferative assay 48 hrs Antiproliferative activity against estrogen receptor deficient human SKBR3 cells after 48 hrs by SRB assay, GI50=0.15μM. 20438092
MCF7/BUS Antiproliferative assay 48 hrs Antiproliferative activity against human MCF7/BUS cells expressing estrogen receptor after 48 hrs by SRB assay, GI50=0.21μM. 20438092
MCF7 Antiproliferative assay 48 hrs Antiproliferative activity against human MCF7 cells expressing estrogen receptor after 48 hrs by SRB assay, GI50=0.28μM. 20438092
MDA-MB-231 Antiproliferative assay 48 hrs Antiproliferative activity against estrogen receptor deficient human MDA-MB-231 cells after 48 hrs by SRB assay, GI50=1.3μM. 20438092
T47D Antiproliferative assay 48 hrs Antiproliferative activity against human T47D cells expressing estrogen receptor after 48 hrs by SRB assay, GI50=2μM. 20438092
K562 Cytotoxicity assay 72 hrs Cytotoxicity against imatinib-resistant human K562 cells after 72 hrs by MTT assay, IC50=0.002μM. 20590148
DA1-3b/M2 Cytotoxicity assay 72 hrs Cytotoxicity against imatinib and dasatinib-resistant mouse DA1-3b/M2 cells after 72 hrs by MTT assay, IC50=0.03μM. 20590148
NCI-H460 Cytotoxicity assay 72 hrs Cytotoxicity against human NCI-H460 cells after 72 hrs by XTT assay, GI50=0.03μM. 20591678
K562 Cytotoxicity assay 72 hrs Cytotoxicity against human K562 cells after 72 hrs by XTT assay, GI50=0.06μM. 20591678
SF268 Cytotoxicity assay 72 hrs Cytotoxicity against human SF268 cells after 72 hrs by XTT assay, GI50=0.19μM. 20591678
MCF7 Cytotoxicity assay 72 hrs Cytotoxicity against human MCF7 cells after 72 hrs by XTT assay, GI50=0.57μM. 20591678
Detroit 551 Cytotoxicity assay 72 hrs Cytotoxicity against human Detroit 551 cells after 72 hrs by XTT assay, GI50=0.99μM. 20591678
HeLa Cytotoxicity assay 4 days Cytotoxicity against human HeLa cells after 4 days by MTT assay, IC50=1.1μM. 20619511
HCT116 Cytotoxicity assay 4 days Cytotoxicity against human HCT116 cells after 4 days by MTT assay, IC50=2.3μM. 20619511
DU145 Cytotoxicity assay 4 days Cytotoxicity against human DU145 cells after 4 days by MTT assay, IC50=3.2μM. 20619511
MDA-MB-231 Cytotoxicity assay 4 days Cytotoxicity against human MDA-MB-231 cells after 4 days by MTT assay, IC50=4.2μM. 20619511
MCF7 Cytotoxicity assay 4 days Cytotoxicity against human MCF7 cells after 4 days by MTT assay, IC50=14.2μM. 20619511
U87MG Cytotoxicity assay 6 days Cytotoxicity against human U87MG cells after 6 days, LD50=0.02μM. 20655220
HeLa Cytotoxicity assay 48 hrs Cytotoxicity against human HeLa cells after 48 hrs by MTT assay, GI50=0.08μM. 20662543
PC3 Cytotoxicity assay 48 hrs Cytotoxicity against human PC3 cells after 48 hrs by MTT assay, GI50=0.09μM. 20662543
SKHep Cytotoxicity assay 48 hrs Cytotoxicity against human SKHep cells after 48 hrs by MTT assay, GI50=0.22μM. 20662543
Detroit 551 Cytotoxicity assay 48 hrs Cytotoxicity against human Detroit 551 cells after 48 hrs by MTT assay, GI50=0.99μM. 20662543
BT-483 Cytotoxicity assay 48 hrs Cytotoxicity against human BT-483 cells after 48 hrs by MTT assay, GI50=1.03μM. 20662543
A549 Cytotoxicity assay 48 hrs Cytotoxicity against human A549 cells after 48 hrs by MTT assay, GI50=2.8μM. 20662543
SAS Cytotoxicity assay 48 hrs Cytotoxicity against human SAS cells after 48 hrs by MTT assay, GI50=6μM. 20662543
HT-29 Cytotoxicity assay 3 days Cytotoxicity against human HT-29 cells after 3 days by sulforhodamine B assay, ED50=0.06μM. 20939540
A549 Cytotoxicity assay 3 days Cytotoxicity against human A549 cells after 3 days by MTT assay, IC50=0.057μM. 20942490
MDA-MB-435 Cytotoxicity assay 3 days Cytotoxicity against human MDA-MB-435 cells after 3 days by MTT assay, IC50=0.71μM. 20942490
LoVo Cytotoxicity assay 3 days Cytotoxicity against human LoVo cells after 3 days by MTT assay, IC50=3.1μM. 20942490
A2780 Cytotoxicity assay 24 hrs Cytotoxicity against human A2780 cells after 24 hrs by MTT assay, IC50=0.2μM. 20961093
A549 Cytotoxicity assay 24 hrs Cytotoxicity against human A549 cells after 24 hrs by MTT assay, IC50=3.6μM. 20961093
HeLa Cytotoxicity assay 72 hrs Cytotoxicity against human HeLa cells after 72 hrs by trypan blue assay, IC50=0.0089μM. 21071230
A431 Cytotoxicity assay 72 hrs Cytotoxicity against human A431 cells after 72 hrs by trypan blue assay, IC50=0.011μM. 21071230
HL60 Cytotoxicity assay 72 hrs Cytotoxicity against human HL60 cells after 72 hrs by trypan blue assay, IC50=0.017μM. 21071230
DU145 Anticancer assay 48 hrs Anticancer activity against human DU145 cells assessed as cell viability after 48 hrs by SRB assay, IC50=0.02μM. 21074444
A549 Anticancer assay 48 hrs Anticancer activity against human A549 cells assessed as cell viability after 48 hrs by SRB assay, IC50=0.03μM. 21074444
PC3 Anticancer assay 48 hrs Anticancer activity against human PC3 cells assessed as cell viability after 48 hrs by SRB assay, IC50=0.03μM. 21074444
HCT15 Anticancer assay 48 hrs Anticancer activity against human HCT15 cells assessed as cell viability after 48 hrs by SRB assay, IC50=0.067μM. 21074444
IMR32 Anticancer assay 48 hrs Anticancer activity against human IMR32 cells assessed as cell viability after 48 hrs by SRB assay, IC50=0.08μM. 21074444
Hep2 Anticancer assay 48 hrs Anticancer activity against human Hep2 cells assessed as cell viability after 48 hrs by SRB assay, IC50=0.7μM. 21074444
MCF7 Cytotoxicity assay 72 hrs Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay, GI50=0.01μM. 21115210
HT-29 Cytotoxicity assay 72 hrs Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay, GI50=0.05μM. 21115210
PC3 Cytotoxicity assay 72 hrs Cytotoxicity against human PC3 cells after 72 hrs by MTT assay, GI50=0.06μM. 21115210
K562 Cytotoxicity assay 72 hrs Cytotoxicity against human K562 cells after 72 hrs by MTT assay, GI50=0.06μM. 21115210
MCF7 Cytotoxicity assay 72 hrs Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay, TGI=0.16μM. 21115210
HT-29 Cytotoxicity assay 72 hrs Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay, LC50=31.62μM. 21115210
HT-29 Cytotoxicity assay 72 hrs Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay, TGI=31.62μM. 21115210
U87 Cytotoxicity assay 72 hrs Cytotoxicity against human U87 cells after 72 hrs by MTT assay, IC50=0.5μM. 21186067
MCF7 Cytotoxicity assay 72 hrs Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay, IC50=0.65μM. 21186067
HeLa Cytotoxicity assay 72 hrs Cytotoxicity against human HeLa cells after 72 hrs by MTT assay, IC50=1.5μM. 21186067
H69 Cytotoxicity assay 72 hrs Cytotoxicity against human H69 cells after 72 hrs by alamar blue assay, IC50=0.001μM. 21341674
PC3 Cytotoxicity assay 72 hrs Cytotoxicity against human PC3 cells after 72 hrs by alamar blue assay, IC50=0.012μM. 21341674
H460 Cytotoxicity assay 72 hrs Cytotoxicity against human H460 cells after 72 hrs by alamar blue assay, IC50=0.013μM. 21341674
MES-SA/Dx5 Cytotoxicity assay 72 hrs Cytotoxicity against human MES-SA/Dx5 cells overexpressing MDR1 after 72 hrs by alamar blue assay, IC50=0.052μM. 21341674
MESSA Cytotoxicity assay 72 hrs Cytotoxicity against human MESSA cells after 72 hrs by alamar blue assay, IC50=0.057μM. 21341674
HT-29 Cytotoxicity assay 72 hrs Cytotoxicity against human HT-29 cells after 72 hrs by alamar blue assay, IC50=0.26μM. 21341674
LoVo Cytotoxicity assay 72 hrs Cytotoxicity against human LoVo cells after 72 hrs by MTT assay, GI50=0.008μM. 21388138
U373 Cytotoxicity assay 72 hrs Cytotoxicity against human U373 cells after 72 hrs by MTT assay, GI50=0.033μM. 21388138
SK-MEL Cytotoxicity assay 72 hrs Cytotoxicity against human SK-MEL cells after 72 hrs by MTT assay, GI50=0.047μM. 21388138
Jurkat Cytotoxicity assay 72 hrs Cytotoxicity against human Jurkat cells after 72 hrs by MTT assay, GI50=0.09μM. 21388138
A549 Cytotoxicity assay 72 hrs Cytotoxicity against human A549 cells after 72 hrs by MTT assay, GI50=0.2μM. 21388138
PC3 Cytotoxicity assay 72 hrs Cytotoxicity against human PC3 cells after 72 hrs by MTT assay, GI50=0.48μM. 21388138
HeLa Cytotoxicity assay 72 hrs Cytotoxicity against human HeLa cells after 72 hrs by MTT assay, GI50=1.3μM. 21388138
MCF7 Cytotoxicity assay 72 hrs Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay, GI50=6μM. 21388138
MDA-MB-231 Cell cycle assay 24 hrs Cell cycle arrest in human MDA-MB-231 cells assessed as increase of cells in sub-G0 phase after 24 hrs using annexin V/propidium iodide staining by flow cytometry 21391655
HL60 Cytotoxicity assay 2 days Cytotoxicity against human HL60 cells after 2 days, IC50=0.065μM. 21419530
DU145 Cytotoxicity assay 2 days Cytotoxicity against human DU145 cells after 2 days, IC50=0.31μM. 21419530
MDA-MB-231 Cytotoxicity assay 2 days Cytotoxicity against human MDA-MB-231 cells after 2 days, IC50=0.97μM. 21419530
HeLa Cytotoxicity assay 2 days Cytotoxicity against human HeLa cells after 2 days, IC50=1.08μM. 21419530
HCT116 Cytotoxicity assay 2 days Cytotoxicity against human HCT116 cells after 2 days, IC50=3.97μM. 21419530
H460 Cytotoxicity assay 72 hrs Cytotoxicity against human H460 cells after 72 hrs by MTS assay, IC50<0.04μM. 21513293
SF268 Cytotoxicity assay 72 hrs Cytotoxicity against human SF268 cells after 72 hrs by MTS assay, IC50=0.04μM. 21513293
MCF7 Cytotoxicity assay 72 hrs Cytotoxicity against human MCF7 cells after 72 hrs by MTS assay, IC50=0.07μM. 21513293
HL60 Cytotoxicity assay 2 days Cytotoxicity against human HL60 cells after 2 days, IC50=0.1μM. 21601964
MDA-MB-231 Cytotoxicity assay 2 days Cytotoxicity against human MDA-MB-231 cells after 2 days, INH=0.3μM. 21601964
HeLa Cytotoxicity assay 2 days Cytotoxicity against human HeLa cells after 2 days, IC50=0.4μM. 21601964
DU145 Cytotoxicity assay 2 days Cytotoxicity against human DU145 cells after 2 days, IC50=0.4μM. 21601964
HCT15 Cytotoxicity assay 2 days Cytotoxicity against human HCT15 cells after 2 days, IC50=0.5μM. 21601964
MIAPaCa2 Cytotoxicity assay 24 hrs Cytotoxicity against human MIAPaCa2 cells after 24 hrs by MTT assay, IC50=0.4μM. 21775156
HOP62 Cytotoxicity assay 48 hrs Cytotoxicity against human HOP62 cells after 48 hrs by SRB assay, GI50=0.01μM. 21823606
UACC62 Cytotoxicity assay 48 hrs Cytotoxicity against human UACC62 cells after 48 hrs by SRB assay, GI50=0.01μM. 21823606
SF539 Cytotoxicity assay 48 hrs Cytotoxicity against human SF539 cells after 48 hrs by SRB assay, GI50=0.01μM. 21823606
DU145 Cytotoxicity assay 48 hrs Cytotoxicity against human DU145 cells after 48 hrs by SRB assay, GI50=0.01μM. 21823606
MCF7 Cytotoxicity assay 48 hrs Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay, GI50=0.013μM. 21823606
SN12C Cytotoxicity assay 48 hrs Cytotoxicity against human SN12C cells after 48 hrs by SRB assay, GI50=0.02μM. 21823606
HCT116 Cytotoxicity assay 48 hrs Cytotoxicity against human HCT116 cells after 48 hrs by SRB assay, GI50=0.03μM. 21823606
OVCAR3 Cytotoxicity assay 48 hrs Cytotoxicity against human OVCAR3 cells after 48 hrs by SRB assay, GI50=0.22μM. 21823606
Caco2 Cytotoxicity assay 24 hrs Cytotoxicity against human Caco2 cells assessed as cell viability after 24 hrs by MTT assay, IC50=9.55μM. 21843907
HT-29 Cytotoxicity assay 24 hrs Cytotoxicity against human HT-29 cells assessed as cell viability after 24 hrs by MTT assay, IC50=10μM. 21843907
HT-29 Function assay 24 hrs Induction of mitochondrial dysfunction in human HT-29 cells assessed as increase in cytosolic cytochrome c level after 24 hrs by enzyme immunometric assay 21843907
Caco2 Function assay 24 hrs Induction of mitochondrial dysfunction in human Caco2 cells assessed as increase in cytosolic cytochrome c level after 24 hrs by enzyme immunometric assay 21843907
A549 Cytotoxicity assay 48 hrs Cytotoxicity against human A549 cells after 48 hrs by MTT assay, IC50=0.091μM. 21873069
HCT15 Cytotoxicity assay 48 hrs Cytotoxicity against human HCT15 cells after 48 hrs by MTT assay, IC50=0.166μM. 21873069
SKOV3 Cytotoxicity assay 48 hrs Cytotoxicity against human SKOV3 cells after 48 hrs by MTT assay, IC50=2.544μM. 21873069
SK-MEL-2 Cytotoxicity assay 48 hrs Cytotoxicity against human SK-MEL-2 cells after 48 hrs by MTT assay, IC50=7.86μM. 21873069
SMMC7721 Cytotoxicity assay 48 hrs Cytotoxicity against human SMMC7721 cells after 48 hrs by SRB assay, IC50=0.003μM. 21973054
MCF7 Antiproliferative assay 72 hrs Antiproliferative activity against human MCF7 cells after 72 hrs by SRB assay, IC50=0.056μM. 21978950
HeLa Cytotoxicity assay 24 hrs Cytotoxicity against human HeLa cells assessed as inhibition of cell viability after 24 hrs by MTT assay, IC50=8.93μM. 21983445
A2780 Cytotoxicity assay 96 hrs Cytotoxicity against human A2780 cells after 96 hrs by MTT assay, IC50=0.26μM. 22044245
HCT8 Cytotoxicity assay 96 hrs Cytotoxicity against human HCT8 cells after 96 hrs by MTT assay, IC50=0.26μM. 22044245
Bel7402 Cytotoxicity assay 96 hrs Cytotoxicity against human Bel7402 cells after 96 hrs by MTT assay, IC50=0.26μM. 22044245
BCG823 Cytotoxicity assay 96 hrs Cytotoxicity against human BCG823 cells after 96 hrs by MTT assay, IC50=0.26μM. 22044245
A549 Cytotoxicity assay 96 hrs Cytotoxicity against human A549 cells after 96 hrs by MTT assay, IC50=0.26μM. 22044245
CCRF-CEM Cytotoxicity assay 96 hrs Cytotoxicity against human CCRF-CEM cells after 96 hrs by MTT assay, CC50=0.003μM. 22047799
CCRF-SB Cytotoxicity assay 96 hrs Cytotoxicity against human CCRF-SB cells after 96 hrs by MTT assay, CC50=0.004μM. 22047799
WIL2-NS Cytotoxicity assay 96 hrs Cytotoxicity against human WIL2-NS cells after 96 hrs by MTT assay, CC50=0.005μM. 22047799
DU145 Cytotoxicity assay 96 hrs Cytotoxicity against human DU145 cells after 96 hrs by MTT assay, CC50=0.015μM. 22047799
MCF7 Cytotoxicity assay 96 hrs Cytotoxicity against human MCF7 cells after 96 hrs by MTT assay, CC50=0.02μM. 22047799
HepG2 Cytotoxicity assay 96 hrs Cytotoxicity against human HepG2 cells after 96 hrs by MTT assay, CC50=0.02μM. 22047799
SKMES1 Cytotoxicity assay 96 hrs Cytotoxicity against human SKMES1 cells after 96 hrs by MTT assay, CC50=0.03μM. 22047799
SK-MEL-28 Cytotoxicity assay 96 hrs Cytotoxicity against human SK-MEL-28 cells after 96 hrs by MTT assay, CC50=0.07μM. 22047799
MRC5 Cytotoxicity assay 96 hrs Cytotoxicity against human MRC5 cells after 96 hrs by MTT assay, CC50=0.2μM. 22047799
CRL7065 Cytotoxicity assay 96 hrs Cytotoxicity against human CRL7065 cells after 96 hrs by MTT assay, CC50=0.3μM. 22047799
MT4 Cytotoxicity assay 96 hrs Cytotoxicity against human MT4 cells after 96 hrs, IC50=0.004μM. 22276775
DU145 Cytotoxicity assay 96 hrs Cytotoxicity against human DU145 cells after 96 hrs, IC50=0.015μM. 22276775
HepG2 Cytotoxicity assay 96 hrs Cytotoxicity against human HepG2 cells after 96 hrs, IC50=0.02μM. 22276775
HCT15 Cytotoxicity assay 2 days Cytotoxicity against human HCT15 cells after 2 days, IC50=0.26μM. 22318164
HeLa Cytotoxicity assay 2 days Cytotoxicity against human HeLa cells after 2 days, IC50=1.01μM. 22318164
K562 Cytotoxicity assay 2 days Cytotoxicity against human K562 cells after 2 days, IC50=1.18μM. 22318164
DU145 Cytotoxicity assay 2 days Cytotoxicity against human DU145 cells after 2 days, IC50=2.37μM. 22318164
MCF7 Cytotoxicity assay 2 days Cytotoxicity against human MCF7 cells after 2 days, IC50=3.91μM. 22318164
A549 Cytotoxicity assay 2 days Cytotoxicity against human A549 cells after 2 days by MTT assay, IC50=0.008μM. 22325897
Jurkat Cytotoxicity assay 2 days Cytotoxicity against human Jurkat cells after 2 days by MTT assay, IC50=0.026μM. 22325897
THP1 Cytotoxicity assay 2 days Cytotoxicity against human THP1 cells after 2 days by MTT assay, IC50=0.071μM. 22325897
HL60 Cytotoxicity assay 2 days Cytotoxicity against human HL60 cells after 2 days by MTT assay, IC50=0.6μM. 22325897
U937 Cytotoxicity assay 2 days Cytotoxicity against human U937 cells after 2 days by MTT assay, IC50=1.98μM. 22325897
HepG2 Cytotoxicity assay 24 hrs Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay, IC50=6.4μM. 22326393
FHCC-98 Cytotoxicity assay 24 hrs Cytotoxicity against human FHCC-98 cells after 24 hrs by MTT assay, IC50=15.2μM. 22326393
QSG7701 Cytotoxicity assay 24 hrs Cytotoxicity against human QSG7701 cells after 24 hrs by MTT assay, IC50=18.3μM. 22326393
SF539 Growth inhibition assay 48 hrs Growth inhibition of human SF539 cells after 48 hrs by sulforhodamine B assay, GI50=0.01μM. 22329436
UACC62 Growth inhibition assay 48 hrs Growth inhibition of human UACC62 cells after 48 hrs by sulforhodamine B assay, GI50=0.01μM. 22329436
DU145 Growth inhibition assay 48 hrs Growth inhibition of human DU145 cells after 48 hrs by sulforhodamine B assay, GI50=0.01μM. 22329436
HOP62 Growth inhibition assay 48 hrs Growth inhibition of human HOP62 cells after 48 hrs by sulforhodamine B assay, GI50=0.01μM. 22329436
MCF7 Growth inhibition assay 48 hrs Growth inhibition of human MCF7 cells after 48 hrs by sulforhodamine B assay, GI50=0.013μM. 22329436
SN12C Growth inhibition assay 48 hrs Growth inhibition of human SN12C cells after 48 hrs by sulforhodamine B assay, GI50=0.02μM. 22329436
HCT116 Growth inhibition assay 48 hrs Growth inhibition of human HCT116 cells after 48 hrs by sulforhodamine B assay, GI50=0.03μM. 22329436
OVCAR3 Growth inhibition assay 48 hrs Growth inhibition of human OVCAR3 cells after 48 hrs by sulforhodamine B assay, GI50=0.22μM. 22329436
HuH7 Cytotoxicity assay 72 hrs Cytotoxicity against human HuH7 cells after 72 hrs by SRB assay, IC50<0.1μM. 22409771
HCT116 Cytotoxicity assay 72 hrs Cytotoxicity against human HCT116 cells after 72 hrs by SRB assay, IC50<0.1μM. 22409771
Mahlavu Cytotoxicity assay 72 hrs Cytotoxicity against human Mahlavu cells after 72 hrs by SRB assay, IC50<0.1μM. 22409771
MCF7 Cytotoxicity assay 72 hrs Cytotoxicity against human MCF7 cells after 72 hrs by SRB assay, IC50<0.1μM. 22409771
HepG2 Cytotoxicity assay 72 hrs Cytotoxicity against human HepG2 cells after 72 hrs by SRB assay, IC50<0.1μM. 22409771
FOCUS Cytotoxicity assay 72 hrs Cytotoxicity against human FOCUS cells after 72 hrs by SRB assay, IC50<0.1μM. 22409771
HEK293 Cytotoxicity assay 2 days Cytotoxicity against human HEK293 cells after 2 days by cell counting kit-8 analysis, IC50=1.01μM. 22503656
DU145 Cytotoxicity assay 2 days Cytotoxicity against human DU145 cells after 2 days by cell counting kit-8 analysis, IC50=1.06μM. 22503656
HCT15 Cytotoxicity assay 2 days Cytotoxicity against human HCT15 cells after 2 days by cell counting kit-8 analysis, IC50=1.38μM. 22503656
T47D Cytotoxicity assay 2 days Cytotoxicity against human T47D cells after 2 days by cell counting kit-8 analysis, IC50=1.53μM. 22503656
HeLa Cytotoxicity assay 48 hrs Cytotoxicity against human HeLa cells after 48 hrs by MTS assay, IC50=0.4μM. 22542106
HeLa Cytotoxicity assay 24 hrs Cytotoxicity against human HeLa cells after 24 hrs by MTS assay, IC50=1.57μM. 22542106
KB-7d Antiproliferative assay 72 hrs Antiproliferative activity against human VP16-resistant KB-7d cells overexpressing MRP after 72 hrs by ethylene blue dye assay, IC50=0.0068μM. 22698783
KB Antiproliferative assay 72 hrs Antiproliferative activity against human KB cells after 72 hrs by ethylene blue dye assay, IC50=0.0088μM. 22698783
KBCPT100 Antiproliferative assay 72 hrs Antiproliferative activity against human partially revertant camptothecin-resistant KBCPT100 cells after 72 hrs by ethylene blue dye assay, IC50=0.024μM. 22698783
KBCPT100 Antiproliferative assay 72 hrs Antiproliferative activity against human camptothecin-resistant KBCPT100 cells after 72 hrs by ethylene blue dye assay, IC50=0.423μM. 22698783
NCI-H460 Cytotoxicity assay 72 hrs Cytotoxicity against human NCI-H460 cells after 72 hrs by sulforhodamine B assay, IC50=0.005μM. 22749423
A2780 Cytotoxicity assay 72 hrs Cytotoxicity against human A2780 cells after 72 hrs by sulforhodamine B assay, IC50=0.007μM. 22749423
GLC4 Cytotoxicity assay 72 hrs Cytotoxicity against human GLC4 cells after 72 hrs by sulforhodamine B assay, IC50=0.01μM. 22749423
NCI-H460 Cytotoxicity assay 72 hrs Cytotoxicity against human NCI-H460 cells incubated for 72 hrs by MTT assay, IC50=0.003μM. 22758788
HEK293 Cytotoxicity assay 72 hrs Cytotoxicity against human HEK293 cells after 72 hrs by MTT assay, IC50=7.94μM. 22819942
T47D Cytotoxicity assay 72 hrs Cytotoxicity against human T47D cells after 72 hrs by MTT assay, IC50=9.17μM. 22819942
DU145 Cytotoxicity assay 72 hrs Cytotoxicity against human DU145 cells after 72 hrs by MTT assay, IC50=9.29μM. 22819942
HCT15 Cytotoxicity assay 72 hrs Cytotoxicity against human HCT15 cells after 72 hrs by MTT assay, IC50=9.92μM. 22819942
NCI-H460 Cytotoxicity assay 3 days Cytotoxicity against human NCI-H460 cells incubated for 3 days by SRB assay, IC50=0.002μM. 22863526
SF268 Cytotoxicity assay 3 days Cytotoxicity against human SF268 cells incubated for 3 days by SRB assay, IC50=0.07μM. 22863526
MCF7 Cytotoxicity assay 3 days Cytotoxicity against human MCF7 cells incubated for 3 days by SRB assay, IC50=0.08μM. 22863526
IMR90 Cytotoxicity assay 3 days Cytotoxicity against human IMR90 cells incubated for 3 days by SRB assay, IC50=0.43μM. 22863526
HL60 Cytotoxicity assay 72 hrs Cytotoxicity against human HL60 cells incubated for 72 hrs by MTT assay, GI50<0.003μM. 22867019
MDA-MB-435 Cytotoxicity assay 72 hrs Cytotoxicity against human MDA-MB-435 cells incubated for 72 hrs by MTT assay, GI50=0.033μM. 22867019
HCT116 Cytotoxicity assay 72 hrs Cytotoxicity against human HCT116 cells incubated for 72 hrs by MTT assay, GI50=0.083μM. 22867019
A549 Cytotoxicity assay 72 hrs Cytotoxicity against human A549 cells incubated for 72 hrs by MTT assay, GI50=0.17μM. 22867019
HepG2 Cytotoxicity assay 72 hrs Cytotoxicity against human HepG2 cells incubated for 72 hrs by MTT assay, GI50=0.22μM. 22867019
PANC1 Cytotoxicity assay 72 hrs Cytotoxicity against human PANC1 cells incubated for 72 hrs by MTT assay, GI50=6.29μM. 22867019
HepG2 Cytotoxicity assay 72 hrs Cytotoxicity against human HepG2 cells incubated for 72 hrs by SRB assay, IC50=0.01μM. 22867707
BT20 Cytotoxicity assay 72 hrs Cytotoxicity against human BT20 cells incubated for 72 hrs by SRB assay, IC50=0.07μM. 22867707
CAMA1 Cytotoxicity assay 72 hrs Cytotoxicity against human CAMA1 cells incubated for 72 hrs by SRB assay, IC50=0.07μM. 22867707
HuH7 Cytotoxicity assay 72 hrs Cytotoxicity against human HuH7 cells incubated for 72 hrs by SRB assay, IC50=0.15μM. 22867707
T47D Cytotoxicity assay 72 hrs Cytotoxicity against human T47D cells incubated for 72 hrs by SRB assay, IC50<1μM. 22867707
MFE296 Cytotoxicity assay 72 hrs Cytotoxicity against human MFE296 cells incubated for 72 hrs by SRB assay, IC50<1μM. 22867707
MV Cytotoxicity assay 72 hrs Cytotoxicity against human MV cells incubated for 72 hrs by SRB assay, IC50<1μM. 22867707
FOCUS Cytotoxicity assay 72 hrs Cytotoxicity against human FOCUS cells incubated for 72 hrs by SRB assay, IC50<1μM. 22867707
HCT116 Cytotoxicity assay 72 hrs Cytotoxicity against human HCT116 cells incubated for 72 hrs by SRB assay, IC50<1μM. 22867707
MCF7 Cytotoxicity assay 72 hrs Cytotoxicity against human MCF7 cells incubated for 72 hrs by SRB assay, IC50<1μM. 22867707
CCRF-CEM Cytotoxicity assay 96 hrs Cytotoxicity against human CCRF-CEM cells after 96 hrs by MTT assay, CC50=0.003μM. 22884523
MT4 Cytotoxicity assay 96 hrs Cytotoxicity against human MT4 cells after 96 hrs by MTT assay, CC50=0.004μM. 22884523
CCRF-SB Cytotoxicity assay 96 hrs Cytotoxicity against human CCRF-SB cells after 96 hrs by MTT assay, CC50=0.004μM. 22884523
WIL2-NS Cytotoxicity assay 96 hrs Cytotoxicity against human WIL2-NS cells after 96 hrs by MTT assay, CC50=0.005μM. 22884523
HepG2 Cytotoxicity assay 96 hrs Cytotoxicity against human HepG2 cells after 96 hrs by MTT assay, CC50=0.04μM. 22884523
SKMES1 Cytotoxicity assay 96 hrs Cytotoxicity against human SKMES1 cells after 96 hrs by MTT assay, CC50=0.05μM. 22884523
SK-MEL-28 Cytotoxicity assay 96 hrs Cytotoxicity against human SK-MEL-28 cells after 96 hrs by MTT assay, CC50=0.07μM. 22884523
DU145 Cytotoxicity assay 96 hrs Cytotoxicity against human DU145 cells after 96 hrs by MTT assay, CC50=0.08μM. 22884523
MCF7 Cytotoxicity assay 96 hrs Cytotoxicity against human MCF7 cells after 96 hrs by MTT assay, CC50=0.08μM. 22884523
MRC5 Cytotoxicity assay 96 hrs Cytotoxicity against human MRC5 cells after 96 hrs by MTT assay, CC50=0.2μM. 22884523
CRL7065 Cytotoxicity assay 96 hrs Cytotoxicity against human CRL7065 cells after 96 hrs by MTT assay, CC50=0.3μM. 22884523
MDA-MB-435 Antiproliferative assay 3 days Antiproliferative activity against human MDA-MB-435 cells after 3 days by MTT assay, IC50=0.0436μM. 23084702
HCT116 Antiproliferative assay 3 days Antiproliferative activity against human HCT116 cells after 3 days by MTT assay, IC50=0.11μM. 23084702
A549 Antiproliferative assay 3 days Antiproliferative activity against human A549 cells after 3 days by MTT assay, IC50=2.61μM. 23084702
HCT116 Cytotoxicity assay 3 days Cytotoxicity against human HCT116 cells after 3 days by SRB assay, IC50<0.01μM. 23142674
SKBR3 Cytotoxicity assay 3 days Cytotoxicity against human SKBR3 cells after 3 days by SRB assay, IC50<0.01μM. 23142674
ZR-75-1 Cytotoxicity assay 3 days Cytotoxicity against human ZR-75-1 cells after 3 days by SRB assay, IC50<0.01μM. 23142674
MCF12A Cytotoxicity assay 3 days Cytotoxicity against human MCF12A cells after 3 days by SRB assay, IC50<0.01μM. 23142674
MCF7 Cytotoxicity assay 3 days Cytotoxicity against human MCF7 cells after 3 days by SRB assay, IC50<0.01μM. 23142674
MDA-MB-453 Cytotoxicity assay 3 days Cytotoxicity against human MDA-MB-453 cells after 3 days by SRB assay, IC50<0.01μM. 23142674
BT20 Cytotoxicity assay 3 days Cytotoxicity against human BT20 cells after 3 days by SRB assay, IC50<0.01μM. 23142674
T47D Cytotoxicity assay 3 days Cytotoxicity against human T47D cells after 3 days by SRB assay, IC50<0.01μM. 23142674
MDA-MB-231 Cytotoxicity assay 3 days Cytotoxicity against human MDA-MB-231 cells after 3 days by SRB assay, IC50<0.01μM. 23142674
MDA-MB-157 Cytotoxicity assay 3 days Cytotoxicity against human MDA-MB-157 cells after 3 days by SRB assay, IC50=0.02μM. 23142674
HuH7 Cytotoxicity assay 3 days Cytotoxicity against human HuH7 cells after 3 days by SRB assay, IC50=0.06μM. 23142674
CAMA1 Cytotoxicity assay 3 days Cytotoxicity against human CAMA1 cells after 3 days by SRB assay, IC50=0.07μM. 23142674
MDA-MB-361 Cytotoxicity assay 3 days Cytotoxicity against human MDA-MB-361 cells after 3 days by SRB assay, IC50=0.17μM. 23142674
BT474 Cytotoxicity assay 3 days Cytotoxicity against human BT474 cells after 3 days by SRB assay, IC50=12.75μM. 23142674
HeLa Cytotoxicity assay 48 hrs Cytotoxicity against human HeLa cells after 48 hrs by MTS assay, IC50=0.4μM. 23153813
HeLa Cytotoxicity assay 24 hrs Cytotoxicity against human HeLa cells after 24 hrs by MTS assay, IC50=1.57μM. 23153813
MCF7 Growth inhibition assay 48 hrs Growth inhibition of human MCF7 cells after 48 hrs by MTT assay, GI50=0.002μM. 23357037
A549 Growth inhibition assay 48 hrs Growth inhibition of human A549 cells after 48 hrs by MTT assay, GI50=0.007μM. 23357037
HeLa Growth inhibition assay 48 hrs Growth inhibition of human HeLa cells after 48 hrs by MTT assay, GI50=0.05μM. 23357037
HepG2 Cytotoxicity assay 72 hrs Cytotoxicity against human HepG2 cells after 72 hrs by SRB assay, IC50=32.3μM. 23562244
HBL100 Antiproliferative assay 48 hrs Antiproliferative activity against human HBL100 cells after 48 hrs by SRB assay, GI50=0.23μM. 23831507
SW1573 Antiproliferative assay 48 hrs Antiproliferative activity against human SW1573 cells after 48 hrs by SRB assay, GI50=0.25μM. 23831507
HeLa Antiproliferative assay 48 hrs Antiproliferative activity against human HeLa cells after 48 hrs by SRB assay, GI50=0.6μM. 23831507
WiDr Antiproliferative assay 48 hrs Antiproliferative activity against human WiDr cells after 48 hrs by SRB assay, GI50=1.8μM. 23831507
T47D Antiproliferative assay 48 hrs Antiproliferative activity against human T47D cells after 48 hrs by SRB assay, GI50=2μM. 23831507
MCF7 Cytotoxicity assay 72 hrs Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay, GI50=0.01μM. 23831811
HT-29 Cytotoxicity assay 72 hrs Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay, GI50=0.05μM. 23831811
MCF7 Cytotoxicity assay 72 hrs Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay, TGI=0.16μM. 23831811
HT-29 Cytotoxicity assay 72 hrs Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay, TGI=0.79μM. 23831811
HT-29 Cytotoxicity assay 72 hrs Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay, LC50=31.62μM. 23831811
MS Cytotoxicity assay 72 hrs Cytotoxicity against human MS cells after 72 hrs ny MTT assay, IC50=0.23μM. 23974020
TE-32 Cytotoxicity assay 72 hrs Cytotoxicity against human TE-32 cells after 72 hrs ny MTT assay, IC50=4.47μM. 23974020
A549 Cytotoxicity assay 72 hrs Cytotoxicity against human A549 cells after 72 hrs ny MTT assay, IC50=37.05μM. 23974020
T47D Cytotoxicity assay 2 days Cytotoxicity against human T47D cells after 2 days by CCK-8 assay, IC50=0.3μM. 24013413
DU145 Cytotoxicity assay 2 days Cytotoxicity against human DU145 cells after 2 days by CCK-8 assay, IC50=0.39μM. 24013413
HCT15 Cytotoxicity assay 2 days Cytotoxicity against human HCT15 cells after 2 days by CCK-8 assay, IC50=0.42μM. 24013413
HEK293 Cytotoxicity assay 2 days Cytotoxicity against HEK293 cells after 2 days by CCK-8 assay, IC50=0.78μM. 24013413
HCT116 Cytotoxicity assay 72 hrs Cytotoxicity against human HCT116 cells after 72 hrs by WST-8 assay, IC50=0.016μM. 24033077
COLO205 Cytotoxicity assay 48 hrs Cytotoxicity against human COLO205 cells after 48 hrs by MTT assay, IC50=0.05μM. 24041234
HL60 Cytotoxicity assay 48 hrs Cytotoxicity against human HL60 cells after 48 hrs by MTT assay, IC50=0.06μM. 24041234
MIAPaCa2 Cytotoxicity assay 48 hrs Cytotoxicity against human MIAPaCa2 cells after 48 hrs by MTT assay, IC50=0.19μM. 24041234
HepG2 Cytotoxicity assay 48 hrs Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay, IC50=0.2μM. 24041234
PC3 Cytotoxicity assay 48 hrs Cytotoxicity against human PC3 cells after 48 hrs by MTT assay, IC50=1.2μM. 24041234
MDA-MB-435 Cytotoxicity assay 72 hrs Cytotoxicity against human MDA-MB-435 cells after 72 hrs by MTT assay, IC50<0.001μM. 24069881
HCT116 Cytotoxicity assay 72 hrs Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay, IC50=0.07μM. 24069881
A549 Cytotoxicity assay 72 hrs Cytotoxicity against human A549 cells after 72 hrs by MTT assay, IC50=0.65μM. 24069881
Hs683 Growth inhibition assay 72 hrs Growth inhibition of human Hs683 cells after 72 hrs by MTT assay, IC50<0.01μM. 24180210
PC3 Growth inhibition assay 72 hrs Growth inhibition of human PC3 cells after 72 hrs by MTT assay, IC50=0.01μM. 24180210
A549 Growth inhibition assay 72 hrs Growth inhibition of human A549 cells after 72 hrs by MTT assay, IC50<0.01μM. 24180210
MCF7 Growth inhibition assay 72 hrs Growth inhibition of human MCF7 cells after 72 hrs by MTT assay, IC50<0.01μM. 24180210
SK-MEL-28 Growth inhibition assay 72 hrs Growth inhibition of human SK-MEL-28 cells after 72 hrs by MTT assay, IC50<0.01μM. 24180210
U373 Growth inhibition assay 72 hrs Growth inhibition of human U373 cells after 72 hrs by MTT assay, IC50=0.015μM. 24180210
K562 Cytotoxicity assay 24 to 72 hrs Cytotoxicity against human K562 cells after 24 to 72 hrs by MTT assay, IC50=0.4μM. 24303808
HeLa Cytotoxicity assay 24 to 72 hrs Cytotoxicity against human HeLa cells after 24 to 72 hrs by MTT assay, IC50=0.5μM. 24303808
HepG2 Cytotoxicity assay 24 to 72 hrs Cytotoxicity against human HepG2 cells after 24 to 72 hrs by MTT assay, IC50=0.6μM. 24303808
DU145 Cytotoxicity assay 24 to 72 hrs Cytotoxicity against human DU145 cells after 24 to 72 hrs by MTT assay, IC50=0.8μM. 24303808
K562 Cytotoxicity assay 48 hrs Cytotoxicity against human K562 cells after 48 hrs by MTT assay, IC50=0.04μM. 24360564
HepG2 Cytotoxicity assay 48 hrs Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay, IC50=0.05μM. 24360564
HT-29 Cytotoxicity assay 48 hrs Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay, IC50=0.06μM. 24360564
CCRF-CEM Cytotoxicity assay 24 hrs Cytotoxicity against human CCRF-CEM cells assessed as cell viability after 24 hrs by MTT assay, IC50=0.08μM. 24484281
CEM/ADR5000 Cytotoxicity assay 24 hrs Cytotoxicity against human CEM/ADR5000 cells assessed as cell viability after 24 hrs by MTT assay, IC50=0.3μM. 24484281
HCT116 Cytotoxicity assay 72 hrs Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay, GI50=0.01738μM. 24502276
DU145 Cytotoxicity assay 72 hrs Cytotoxicity against human DU145 cells after 72 hrs by MTT assay, GI50=0.0182μM. 24502276
HCT116 Cytotoxicity assay 72 hrs Cytotoxicity against human HCT116 cells transfected with Top1-siRNA after 72 hrs by MTT assay, GI50=0.03548μM. 24502276
B16F10 Cytotoxicity assay 48 hrs Cytotoxicity against mouse B16F10 cells after 48 hrs by MTT assay, IC50=2.78μM. 24685545
DU145 Growth inhibition assay 48 hrs Growth inhibition of human DU145 cells after 48 hrs by SRB assay, GI50=0.01μM. 24800942
HOP62 Growth inhibition assay 48 hrs Growth inhibition of human HOP62 cells after 48 hrs by SRB assay, GI50=0.01μM. 24800942
MCF7 Growth inhibition assay 48 hrs Growth inhibition of human MCF7 cells after 48 hrs by SRB assay, GI50=0.01μM. 24800942
SF539 Growth inhibition assay 48 hrs Growth inhibition of human SF539 cells after 48 hrs by SRB assay, GI50=0.01μM. 24800942
UACC62 Growth inhibition assay 48 hrs Growth inhibition of human UACC62 cells after 48 hrs by SRB assay, GI50=0.01μM. 24800942
SN12C Growth inhibition assay 48 hrs Growth inhibition of human SN12C cells after 48 hrs by SRB assay, GI50=0.02μM. 24800942
HCT116 Growth inhibition assay 48 hrs Growth inhibition of human HCT116 cells after 48 hrs by SRB assay, GI50=0.03μM. 24800942
OVCAR3 Growth inhibition assay 48 hrs Growth inhibition of human OVCAR3 cells after 48 hrs by SRB assay, GI50=0.22μM. 24800942
MOLT4 Cytotoxicity assay 72 hrs Cytotoxicity against human MOLT4 cells after 72 hrs by MTT assay, IC50=0.00004μM. 24900725
A2780 Cytotoxicity assay 72 hrs Cytotoxicity against human A2780 cells after 72 hrs by MTT assay, IC50=0.013μM. 24900725
HeLa Cytotoxicity assay 72 hrs Cytotoxicity against human HeLa cells after 72 hrs by MTT assay, IC50=0.024μM. 24900725
MCF7 Cytotoxicity assay 72 hrs Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay, IC50=0.026μM. 24900725
K562 Cytotoxicity assay 72 hrs Cytotoxicity against human K562 cells after 72 hrs by MTT assay, IC50=0.031μM. 24900725
PC3 Cytotoxicity assay 72 hrs Cytotoxicity against human PC3 cells after 72 hrs by MTT assay, IC50=0.078μM. 24900725
A549 Cytotoxicity assay 72 hrs Cytotoxicity against human A549 cells after 72 hrs by MTT assay, IC50=0.099μM. 24900725
MDA-MB-231 Cytotoxicity assay 72 hrs Cytotoxicity against human MDA-MB-231 cells after 72 hrs by MTT assay, IC50=0.162μM. 24900725
MCF7 Cytotoxicity assay 72 hrs Cytotoxicity against human MCF7 cells overexpressing biotin receptor assessed as growth inhibition after 72 hrs by MTT assay, IC50=0.0651μM. 24901491
ID8 Cytotoxicity assay 72 hrs Cytotoxicity against mouse ID8 cells overexpressing biotin receptor assessed as growth inhibition after 72 hrs by MTT assay, IC50=0.474μM. 24901491
L1210 Cytotoxicity assay 72 hrs Cytotoxicity against mouse L1210 cells overexpressing folate receptor assessed as growth inhibition after 72 hrs by MTT assay, IC50=0.51μM. 24901491
WI38 Cytotoxicity assay 72 hrs Cytotoxicity against human WI38 cells overexpressing biotin receptor assessed as growth inhibition after 72 hrs by MTT assay, IC50=0.786μM. 24901491
MX1 Cytotoxicity assay 72 hrs Cytotoxicity against human MX1 cells overexpressing biotin receptor assessed as growth inhibition after 72 hrs by MTT assay, IC50=1.7μM. 24901491
MCF10A Cytotoxicity assay 2 days Cytotoxicity against human MCF10A cells after 2 days, IC50=0.27μM. 24904965
T47D Cytotoxicity assay 2 days Cytotoxicity against human T47D cells after 2 days, IC50=0.28μM. 24904965
DU145 Cytotoxicity assay 2 days Cytotoxicity against human DU145 cells after 2 days, IC50=4.01μM. 24904965
HCT15 Cytotoxicity assay 2 days Cytotoxicity against human HCT15 cells after 2 days, IC50=10.07μM. 24904965
Jurkat Cytotoxicity assay 24 hrs Cytotoxicity against human Jurkat cells after 24 hrs by MTT assay, IC50=0.11μM. 24980118
Caco2 Cytotoxicity assay 24 hrs Cytotoxicity against human Caco2 cells after 24 hrs by MTT assay, IC50=0.131μM. 24980118
A375 Cytotoxicity assay 24 hrs Cytotoxicity against human A375 cells after 24 hrs by MTT assay, IC50=0.187μM. 24980118
MDA-MB-231 Cytotoxicity assay 24 hrs Cytotoxicity against human MDA-MB-231 cells after 24 hrs by MTT assay, IC50=0.342μM. 24980118
HeLa Cytotoxicity assay 24 hrs Cytotoxicity against human HeLa cells after 24 hrs by MTT assay, IC50=0.42μM. 24980118
A549 Cytotoxicity assay 72 hrs Cytotoxicity against human A549 cells after 72 hrs by SRB assay, IC50=0.016μM. 25003995
DU145 Cytotoxicity assay 72 hrs Cytotoxicity against human DU145 cells after 72 hrs by SRB assay, IC50=0.029μM. 25003995
KB Cytotoxicity assay 72 hrs Cytotoxicity against human KB cells after 72 hrs by SRB assay, IC50=0.037μM. 25003995
KBVIN Cytotoxicity assay 72 hrs Cytotoxicity against human KBVIN cells after 72 hrs by SRB assay, IC50=0.12μM. 25003995
HEK293 Cytotoxicity assay 4 days Cytotoxicity against HEK293 cells after 4 days by CCK-8 assay, IC50=0.28μM. 25062006
T47D Cytotoxicity assay 4 days Cytotoxicity against human T47D cells after 4 days by CCK-8 assay, IC50=0.75μM. 25062006
DU145 Cytotoxicity assay 4 days Cytotoxicity against human DU145 cells after 4 days by CCK-8 assay, IC50=0.95μM. 25062006
HCT15 Cytotoxicity assay 4 days Cytotoxicity against human HCT15 cells after 4 days by CCK-8 assay, IC50=1.98μM. 25062006
MCF7 Cytotoxicity assay 48 hrs Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay, IC50=0.0005μM. 25084144
MCF7 Cytotoxicity assay 48 hrs Cytotoxicity against human MCF7 cells in presence of 10 mM DTT after 48 hrs by SRB assay, IC50=0.003μM. 25084144
A549 Cytotoxicity assay 48 hrs Cytotoxicity against human A549 cells after 48 hrs by SRB assay, IC50=1.3μM. 25084144
HCT116 Cytotoxicity assay 72 hrs Cytotoxicity against human HCT116 cells after 72 hrs by SRB assay, IC50=0.00015μM. 25247770
MCF7 Cytotoxicity assay 72 hrs Cytotoxicity against human MCF7 cells after 72 hrs by SRB assay, IC50=0.0006μM. 25247770
HuH7 Cytotoxicity assay 72 hrs Cytotoxicity against human HuH7 cells after 72 hrs by SRB assay, IC50=0.004μM. 25247770
SMMC7721 Cytotoxicity assay 48 hrs Cytotoxicity against human SMMC7721 cells assessed as inhibition of cell viability after 48 hrs by MTT assay 25453788
MCF7 Cytotoxicity assay 48 hrs Cytotoxicity against human MCF7 cells assessed as inhibition of cell viability after 48 hrs by MTT assay 25453788
MCF7 Cytotoxicity assay 2 days Cytotoxicity against human MCF7 cells after 2 days by CCK-8 assay, IC50=0.08μM. 25481396
DU145 Cytotoxicity assay 2 days Cytotoxicity against human DU145 cells after 2 days by CCK-8 assay, IC50=0.11μM. 25481396
HCT15 Cytotoxicity assay 2 days Cytotoxicity against human HCT15 cells after 2 days by CCK-8 assay, IC50=0.26μM. 25481396
HeLa Cytotoxicity assay 2 days Cytotoxicity against human HeLa cells after 2 days by CCK-8 assay, IC50=0.4μM. 25481396
K562 Antitumor assay 48 hrs Antitumor activity against human K562 cells incubated for 48 hrs by MTT assay, IC50=0.13μM. 25590864
HL60 Cytotoxicity assay 48 hrs Cytotoxicity against human HL60 cells after 48 hrs by MTT assay, IC50=0.07μM. 25599951
K562 Cytotoxicity assay 48 hrs Cytotoxicity against human K562 cells after 48 hrs by MTT assay, IC50=5.37μM. 25599951
HeLa Cytotoxicity assay 48 hrs Cytotoxicity against human HeLa cells after 48 hrs by MTT assay, IC50=11.62μM. 25599951
A549 Cytotoxicity assay 48 hrs Cytotoxicity against human A549 cells after 48 hrs by MTT assay, IC50=26.45μM. 25599951
DU145 Antiproliferative assay 72 hrs Antiproliferative activity against human DU145 cells assessed as cell viability incubated for 72 hrs by MTT assay, IC50=0.1μM. 25799376
PC3 Antiproliferative assay 72 hrs Antiproliferative activity against human PC3 cells assessed as cell viability incubated for 72 hrs by MTT assay, IC50=0.1μM. 25799376
T47D Cytotoxicity assay 2 to 4 days Cytotoxicity against human T47D cells incubated from day 2 to day 4 by CCK8 assay, IC50=0.31μM. 26022080
DU145 Cytotoxicity assay 2 to 4 days Cytotoxicity against human DU145 cells incubated from day 2 to day 4 by CCK8 assay, IC50=0.4μM. 26022080
HeLa Cytotoxicity assay 2 to 4 days Cytotoxicity against human HeLa cells incubated from day 2 to day 4 by CCK8 assay, IC50=0.41μM. 26022080
HCT15 Cytotoxicity assay 2 to 4 days Cytotoxicity against human HCT15 cells incubated from day 2 to day 4 by CCK8 assay, IC50=0.52μM. 26022080
HL60 Cytotoxicity assay 48 hrs Cytotoxicity against human HL60 cells after 48 hrs by MTT assay, IC50=0.015μM. 26188908
CA46 Cytotoxicity assay 48 hrs Cytotoxicity against human CA46 cells after 48 hrs by MTT assay, IC50=0.52μM. 26188908
A549 Cytotoxicity assay 48 hrs Cytotoxicity against human A549 cells after 48 hrs by MTT assay, IC50=1.6μM. 26188908
HeLa Cytotoxicity assay 48 hrs Cytotoxicity against human HeLa cells after 48 hrs by MTT assay, IC50=14μM. 26188908
K562 Cytotoxicity assay 72 hrs Cytotoxicity against human K562 cells after 72 hrs by MTT assay, IC50<0.003μM. 26226379
MV-3 Cytotoxicity assay 72 hrs Cytotoxicity against human MV-3 cells after 72 hrs by MTT assay, IC50<0.003μM. 26226379
HCT116 Cytotoxicity assay 72 hrs Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay, IC50=0.09μM. 26226379
A549 Cytotoxicity assay 72 hrs Cytotoxicity against human A549 cells after 72 hrs by MTT assay, IC50=0.1μM. 26226379
Bel7404 Cytotoxicity assay 72 hrs Cytotoxicity against human Bel7404 cells after 72 hrs by MTT assay, IC50=0.14μM. 26226379
SW579 Cytotoxicity assay 72 hrs Cytotoxicity against human SW579 cells after 72 hrs by MTT assay, IC50=0.71μM. 26226379
SKHEP1 Cytotoxicity assay 72 hrs Cytotoxicity against human SKHEP1 cells after 72 hrs by MTT assay, IC50=0.96μM. 26226379
MDA-MB-435 Cytotoxicity assay 72 hrs Cytotoxicity against human MDA-MB-435 cells after 72 hrs by MTT assay, IC50=1μM. 26226379
PC3 Cytotoxicity assay 72 hrs Cytotoxicity against human PC3 cells after 72 hrs by MTT assay, IC50=2.5μM. 26226379
HeLa Cytotoxicity assay 2 days Cytotoxicity against human HeLa cells measured after 2 days by MTT assay, IC50=1.59μM. 26334499
T47D Cytotoxicity assay 2 days Cytotoxicity against human T47D cells measured after 2 days by MTT assay, IC50=1.62μM. 26334499
HCT15 Cytotoxicity assay 2 days Cytotoxicity against human HCT15 cells measured after 2 days by MTT assay, IC50=6.08μM. 26334499
T47D Cytotoxicity assay 2 days Cytotoxicity against human T47D cells after 2 days by CCK8 assay, IC50=0.08μM. 26361737
DU145 Cytotoxicity assay 2 days Cytotoxicity against human DU145 cells after 2 days by CCK8 assay, IC50=0.11μM. 26361737
HCT15 Cytotoxicity assay 2 days Cytotoxicity against human HCT15 cells after 2 days by CCK8 assay, IC50=0.3μM. 26361737
MCF10A Cytotoxicity assay 2 days Cytotoxicity against human MCF10A cells after 2 days by CCK8 assay, IC50=0.97μM. 26361737
184B5 Antiproliferative assay 72 hrs Antiproliferative activity against human 184B5 cells after 72 hrs by SRB assay, IC50=4.96μM. 26602827
MDA-MB-231 Antiproliferative assay 72 hrs Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by SRB assay, IC50=5.77μM. 26602827
HeLa Antiproliferative assay 72 hrs Antiproliferative activity against human HeLa cells after 72 hrs by SRB assay, IC50=6.13μM. 26602827
MDA-MB-468 Antiproliferative assay 72 hrs Antiproliferative activity against human MDA-MB-468 cells after 72 hrs by SRB assay, IC50=14.76μM. 26602827
GM07492A Cytotoxicity assay 24 hrs Cytotoxicity against human GM07492A cells assessed as cell growth inhibition after 24 hrs by XTT assay, IC50=3.2μM. 26649907
M059J Cytotoxicity assay 24 hrs Cytotoxicity against human M059J cells assessed as cell growth inhibition after 24 hrs by XTT assay, IC50=5.5μM. 26649907
MCF7 Cytotoxicity assay 24 hrs Cytotoxicity against human MCF7 cells assessed as cell growth inhibition after 24 hrs by XTT assay, IC50=6μM. 26649907
HeLa Cytotoxicity assay 24 hrs Cytotoxicity against human HeLa cells assessed as cell growth inhibition after 24 hrs by XTT assay, IC50=19.8μM. 26649907
B16F10 Cytotoxicity assay 24 hrs Cytotoxicity against mouse B16F10 cells overexpressing alphavbeta3 integrin up to 50 uM after 24 hrs by XTT assay 26719208
Mahlavu Cytotoxicity assay 72 hrs Cytotoxicity against human Mahlavu cells assessed as growth inhibition after 72 hrs by sulforhodamine B assay, IC50<1μM. 26810835
Hep3B Cytotoxicity assay 72 hrs Cytotoxicity against human Hep3B cells assessed as growth inhibition after 72 hrs by sulforhodamine B assay, IC50<1μM. 26810835
HepG2 Cytotoxicity assay 72 hrs Cytotoxicity against human HepG2 cells assessed as growth inhibition after 72 hrs by sulforhodamine B assay, IC50<1μM. 26810835
SNU475 Cytotoxicity assay 72 hrs Cytotoxicity against human SNU475 cells assessed as growth inhibition after 72 hrs by sulforhodamine B assay, IC50<1μM. 26810835
FOCUS Cytotoxicity assay 72 hrs Cytotoxicity against human FOCUS cells assessed as growth inhibition after 72 hrs by sulforhodamine B assay, IC50<1μM. 26810835
Jurkat Anticancer assay 48 hrs Anticancer activity against human Jurkat cells after 48 hrs by MTT assay, IC50=0.085μM. 26890120
HeLa Cytotoxicity assay 3 days Cytotoxicity against human HeLa cells after 3 days by CCK8 assay, IC50=0.59μM. 26927425
HCT15 Cytotoxicity assay 3 days Cytotoxicity against human HCT15 cells after 3 days by CCK8 assay, IC50=1.29μM. 26927425
T47D Cytotoxicity assay 3 days Cytotoxicity against human T47D cells after 3 days by CCK8 assay, IC50=11.17μM. 26927425
DU145 Cytotoxicity assay 48 hrs Cytotoxicity against human DU145 cells after 48 hrs by CCK8 assay, IC50=0.02μM. 26945111
HeLa Cytotoxicity assay 48 hrs Cytotoxicity against human HeLa cells after 48 hrs by CCK8 assay, IC50=0.18μM. 26945111
T47D Cytotoxicity assay 48 hrs Cytotoxicity against human T47D cells after 48 hrs by CCK8 assay, IC50=1.84μM. 26945111
HCT15 Cytotoxicity assay 48 hrs Cytotoxicity against human HCT15 cells after 48 hrs by CCK8 assay, IC50=2.82μM. 26945111
T47D Antiproliferative assay 72 hrs Antiproliferative activity against human T47D cells after 72 hrs by CCK8 assay, IC50=4.1μM. 26988802
BT474 Antiproliferative assay 72 hrs Antiproliferative activity against human BT474 cells after 72 hrs by CCK8 assay, IC50=7μM. 26988802
HCT15 Antiproliferative assay 72 hrs Antiproliferative activity against human HCT15 cells after 72 hrs by CCK8 assay, IC50=7.1μM. 26988802
A549 Cytotoxicity assay 72 hrs Cytotoxicity against human A549 cells after 72 hrs by sulforhodamine B colorimetric assay, IC50=0.016μM. 26994847
KB Cytotoxicity assay 72 hrs Cytotoxicity against human KB cells after 72 hrs by sulforhodamine B colorimetric assay, IC50=0.037μM. 26994847
KBVIN Cytotoxicity assay 72 hrs Cytotoxicity against human KBVIN cells after 72 hrs by sulforhodamine B colorimetric assay, IC50=0.12μM. 26994847
A549 Cytotoxicity assay 48 hrs Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by CCK8 assay, IC50=0.001μM. 27017547
SKOV3 Cytotoxicity assay 48 hrs Cytotoxicity against human SKOV3 cells assessed as growth inhibition after 48 hrs by CCK8 assay, IC50=0.0055μM. 27017547
BT20 Cytotoxicity assay 48 hrs Cytotoxicity against human BT20 cells assessed as growth inhibition after 48 hrs by CCK8 assay, IC50=0.07μM. 27017547
MCF7 Antiproliferative assay 48 hrs Antiproliferative activity against human MCF7 cells after 48 hrs, GI50=0.01μM. 27070999
SF539 Antiproliferative assay 48 hrs Antiproliferative activity against human SF539 cells after 48 hrs, GI50=0.01μM. 27070999
DU145 Antiproliferative assay 48 hrs Antiproliferative activity against human DU145 cells after 48 hrs, GI50=0.01μM. 27070999
HOP62 Antiproliferative assay 48 hrs Antiproliferative activity against human HOP62 cells after 48 hrs, GI50=0.01μM. 27070999
UACC62 Antiproliferative assay 48 hrs Antiproliferative activity against human UACC62 cells after 48 hrs, GI50=0.01μM. 27070999
SN12C Antiproliferative assay 48 hrs Antiproliferative activity against human SN12C cells after 48 hrs, GI50=0.02μM. 27070999
HCT116 Antiproliferative assay 48 hrs Antiproliferative activity against human HCT116 cells after 48 hrs, GI50=0.03μM. 27070999
OVCAR3 Antiproliferative assay 48 hrs Antiproliferative activity against human OVCAR3 cells after 48 hrs, GI50=0.22μM. 27070999
HCT116 Antiproliferative assay 72 hrs Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by ATPlite assay, IC50=0.003μM. 27096049
A549 Antiproliferative assay 72 hrs Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 72 hrs by ATPlite assay, IC50=0.009μM. 27096049
A375 Antiproliferative assay 72 hrs Antiproliferative activity against human A375 cells assessed as reduction in cell viability after 72 hrs by ATPlite assay, IC50=0.013μM. 27096049
HL60 Antiproliferative assay 72 hrs Antiproliferative activity against human HL60 cells assessed as reduction in cell viability after 72 hrs by ATPlite assay, IC50=0.035μM. 27096049
NCI-H23 Cytotoxicity assay 96 hrs Cytotoxicity against human NCI-H23 cells assessed as cell viability after 96 hrs by MTT assay, IC50=0.07μM. 27156772
NCI-H460 Cytotoxicity assay 96 hrs Cytotoxicity against human NCI-H460 cells assessed as cell viability after 96 hrs by MTT assay, IC50=0.19μM. 27156772
A549 Cytotoxicity assay 96 hrs Cytotoxicity against human A549 cells assessed as cell viability after 96 hrs by MTT assay, IC50=0.35μM. 27156772
A549 Growth inhibition assay 72 hrs Growth inhibition of human A549 cells after 72 hrs by MTT assay, IC50=0.12μM. 27344492
HepG2 Growth inhibition assay 72 hrs Growth inhibition of human HepG2 cells after 72 hrs by MTT assay, IC50=29.81μM. 27344492
A549 Antiproliferative assay 48 hrs Antiproliferative activity against human A549 cells after 48 hrs by MTT assay, IC50=0.46μM. 27416553
BGC823 Antiproliferative assay 48 hrs Antiproliferative activity against human BGC823 cells after 48 hrs by MTT assay, IC50=1.27μM. 27416553
HeLa Antiproliferative assay 48 hrs Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay, IC50=1.41μM. 27416553
HepG2 Antiproliferative assay 48 hrs Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay, IC50=1.52μM. 27416553
NCI60 Cytotoxicity assay 48 hrs Cytotoxicity against human NCI60 cells after 48 hrs by SRB assay, GI50=0.0398μM. 27448924
HCT15 Cytotoxicity assay 72 hrs Cytotoxicity against human HCT15 cells assessed as reduction in cell growth after 72 hrs by CCK8 assay, IC50=0.0014μM. 27484510
T47D Cytotoxicity assay 72 hrs Cytotoxicity against human T47D cells assessed as reduction in cell growth after 72 hrs by CCK8 assay, IC50=0.08μM. 27484510
HeLa Cytotoxicity assay 72 hrs Cytotoxicity against human HeLa cells assessed as reduction in cell growth after 72 hrs by CCK8 assay, IC50=0.13μM. 27484510
NCI-N87 Cytotoxicity assay 72 hrs Cytotoxicity against human NCI-N87 cells assessed as reduction in cell growth after 72 hrs by CCK8 assay, IC50=0.6μM. 27484510
H460 Growth inhibition assay 72 hrs Growth inhibition of human H460 cells after 72 hrs by trypan blue assay, GI50=0.002μM. 27597409
MSTO-211H Growth inhibition assay 72 hrs Growth inhibition of human MSTO-211H cells after 72 hrs by trypan blue assay, GI50=0.0021μM. 27597409
HeLa Growth inhibition assay 72 hrs Growth inhibition of human HeLa cells after 72 hrs by trypan blue assay, GI50=0.0054μM. 27597409
DU145 Antiproliferative assay 72 hrs Antiproliferative activity against human DU145 cells after 72 hrs by CCK8 assay, IC50=0.11μM. 27643560
HCT15 Antiproliferative assay 72 hrs Antiproliferative activity against human HCT15 cells after 72 hrs by CCK8 assay, IC50=0.31μM. 27643560
HeLa Antiproliferative assay 72 hrs Antiproliferative activity against human HeLa cells after 72 hrs by CCK8 assay, IC50=0.4μM. 27643560
HEK293 Antiproliferative assay 72 hrs Antiproliferative activity against HEK293 cells after 72 hrs by CCK8 assay, IC50=0.83μM. 27643560
HFL1 Antiproliferative assay 72 hrs Antiproliferative activity against HFL1 cells after 72 hrs by CCK8 assay, IC50=1.06μM. 27643560
T47D Antiproliferative assay 72 hrs Antiproliferative activity against human T47D cells after 72 hrs by CCK8 assay, IC50=13.7μM. 27643560
HCT15 Antiproliferative assay 72 hrs Antiproliferative activity against human HCT15 cells measured after 72 hrs by CCK8 assay, IC50=0.35μM. 27654394
DU145 Antiproliferative assay 72 hrs Antiproliferative activity against human DU145 cells measured after 72 hrs by CCK8 assay, IC50=0.38μM. 27654394
T47D Antiproliferative assay 72 hrs Antiproliferative activity against human T47D cells measured after 72 hrs by CCK8 assay, IC50=0.59μM. 27654394
MCF7 Antiproliferative assay 72 hrs Antiproliferative activity against human MCF7 cells measured after 72 hrs by CCK8 assay, IC50=4.54μM. 27654394
ECA109 Cytotoxicity assay 48 hrs Cytotoxicity against human ECA109 cells assessed as decrease in cell proliferation after 48 hrs by MTT assay, IC50=9.52μM. 27667553
HeLa Cytotoxicity assay 48 hrs Cytotoxicity against human HeLa cells assessed as decrease in cell proliferation after 48 hrs by MTT assay, IC50=11.36μM. 27667553
HEK293 Cytotoxicity assay 72 hrs Cytotoxicity against human HEK293 cells measured after 72 hrs by MTT assay, IC50=0.89μM. 27721148
TE32 Cytotoxicity assay 72 hrs Cytotoxicity against human TE32 cells measured after 72 hrs by MTT assay, IC50=1.24μM. 27721148
MS Cytotoxicity assay 72 hrs Cytotoxicity against human MS cells measured after 72 hrs by MTT assay, IC50=1.84μM. 27721148
Hep2 Cytotoxicity assay 72 hrs Cytotoxicity against human Hep2 cells measured after 72 hrs by MTT assay, IC50=3.04μM. 27721148
A549 Cytotoxicity assay 72 hrs Cytotoxicity against human A549 cells measured after 72 hrs by MTT assay, IC50=5.93μM. 27721148
HCT116 Cytotoxicity assay 72 hrs Cytotoxicity against human HCT116 cells measured after 72 hrs by MTT assay, IC50=6.7μM. 27721148
A549 Antiproliferative assay 96 hrs Antiproliferative activity against human A549 cells after 96 hrs by MTT assay, IC50=0.006μM. 27871039
Bel7402 Antiproliferative assay 96 hrs Antiproliferative activity against human Bel7402 cells after 96 hrs by MTT assay, IC50=0.014μM. 27871039
HCT8 Antiproliferative assay 96 hrs Antiproliferative activity against human HCT8 cells after 96 hrs by MTT assay, IC50=0.024μM. 27871039
A2780 Antiproliferative assay 96 hrs Antiproliferative activity against human A2780 cells after 96 hrs by MTT assay, IC50=0.029μM. 27871039
BGC823 Antiproliferative assay 96 hrs Antiproliferative activity against human BGC823 cells after 96 hrs by MTT assay, IC50=0.057μM. 27871039
MCF7 Cytotoxicity assay 72 hrs Cytotoxicity against vinblastine-sensitive human MCF7 cells assessed as growth inhibition after 72 hrs by SRB assay, IC50<0.0018μM. 28006904
MCF7 Cytotoxicity assay 72 hrs Cytotoxicity against multidrug resistant human MCF7 cells cultured in vinblastine free medium assessed as growth inhibition after 72 hrs by SRB assay, IC50<0.0018μM. 28006904
MCF7 Cytotoxicity assay 72 hrs Cytotoxicity against multidrug resistant human MCF7 cells cultured in vinblastine containing medium assessed as growth inhibition after 72 hrs by SRB assay, IC50<0.0018μM. 28006904
HEK293 Cytotoxicity assay 48 hrs Cytotoxicity against HEK293 cells measured after 48 hrs by MTT assay, IC50=0.01μM. 28027871
A549 Cytotoxicity assay 48 hrs Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay, IC50=0.24μM. 28063351
HeLa Antiproliferative assay 72 hrs Antiproliferative activity against human HeLa cells after 72 hrs by CCK8 assay, IC50=0.09μM. 28068603
HCT15 Antiproliferative assay 72 hrs Antiproliferative activity against human HCT15 cells after 72 hrs by CCK8 assay, IC50=0.6μM. 28068603
T47D Antiproliferative assay 72 hrs Antiproliferative activity against human T47D cells after 72 hrs by CCK8 assay, IC50=2.1μM. 28068603
CCRF-CEM Cytotoxicity assay 72 hrs Cytotoxicity against human CCRF-CEM cells assessed as reduction in cell viability after 72 hrs by resazurin reduction assay, IC50=0.003μM. 28233677
CEM/ADR5000 Cytotoxicity assay 72 hrs Cytotoxicity against human CEM/ADR5000 cells assessed as reduction in cell viability after 72 hrs by resazurin reduction assay, IC50=0.011μM. 28233677
A549 Cytotoxicity assay 72 hrs Cytotoxicity against human A549 cells after 72 hrs by sulforhodamine B assay, IC50=0.00863μM. 28285912
KBVIN Cytotoxicity assay 72 hrs Cytotoxicity against human KBVIN cells after 72 hrs by sulforhodamine B assay, IC50=0.0157μM. 28285912
KB Cytotoxicity assay 72 hrs Cytotoxicity against human KB cells after 72 hrs by sulforhodamine B assay, IC50=0.05μM. 28285912
MCF7 Cytotoxicity assay 72 hrs Cytotoxicity against human MCF7 cells after 72 hrs by sulforhodamine B assay, IC50=0.0875μM. 28285912
MDA-MB-231 Cytotoxicity assay 72 hrs Cytotoxicity against human MDA-MB-231 cells after 72 hrs by sulforhodamine B assay, IC50=0.307μM. 28285912
HCT116 Antiproliferative assay 72 hrs Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay, IC50=0.12μM. 28351590
ZR-7530 Antiproliferative assay 72 hrs Antiproliferative activity against human ZR-7530 cells after 72 hrs by MTT assay, IC50=0.24μM. 28351590
A549 Antiproliferative assay 72 hrs Antiproliferative activity against human A549 cells after 72 hrs by MTT assay, IC50=0.26μM. 28351590
HeLa Antiproliferative assay 72 hrs Antiproliferative activity against human HeLa cells after 72 hrs by CCK8 assay, IC50=0.06μM. 28384547
HCT15 Antiproliferative assay 72 hrs Antiproliferative activity against human HCT15 cells after 72 hrs by CCK8 assay, IC50=0.26μM. 28384547
T47D Antiproliferative assay 72 hrs Antiproliferative activity against human T47D cells after 72 hrs by CCK8 assay, IC50=2.1μM. 28384547
MCF7 Cytotoxicity assay 3 days Cytotoxicity against human MCF7 cells after 3 days by sulforhodamine B assay, IC50=0.073μM. 28409637
HOP62 Cytotoxicity assay 48 hrs Cytotoxicity against human HOP62 cells after 48 hrs by SRB assay, GI50<0.01μM. 28418653
SF539 Cytotoxicity assay 48 hrs Cytotoxicity against human SF539 cells after 48 hrs by SRB assay, GI50<0.01μM. 28418653
UACC62 Cytotoxicity assay 48 hrs Cytotoxicity against human UACC62 cells after 48 hrs by SRB assay, GI50<0.01μM. 28418653
MCF7 Cytotoxicity assay 48 hrs Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay, GI50=0.013μM. 28418653
SN12C Cytotoxicity assay 48 hrs Cytotoxicity against human SN12C cells after 48 hrs by SRB assay, GI50=0.02μM. 28418653
OVCAR3 Cytotoxicity assay 48 hrs Cytotoxicity against human OVCAR3 cells after 48 hrs by SRB assay, GI50=0.22μM. 28418653
HCT116 Cytotoxicity assay 48 hrs Cytotoxicity against human HCT116 cells after 48 hrs by MTT assay, IC50=0.0115μM. 28454671
MGC803 Antiproliferative assay 48 hrs Antiproliferative activity against human MGC803 cells after 48 hrs by MTT assay, IC50=9.45μM. 28462840
HeLa Antiproliferative assay 48 hrs Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay, IC50=10.1μM. 28462840
A549 Antiproliferative assay 48 hrs Antiproliferative activity against human A549 cells after 48 hrs by MTT assay, IC50=13.64μM. 28462840
MCF7 Antiproliferative assay 48 hrs Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay, IC50=28.66μM. 28462840
HL60 Antiproliferative assay 48 hrs Antiproliferative activity against human HL60 cells measured after 48 hrs by WST1 assay, IC50=0.019μM. 28477443
HCT116 Antiproliferative assay 48 hrs Antiproliferative activity against human HCT116 cells measured after 48 hrs by MTT assay, IC50=0.159μM. 28477443
A549 Antiproliferative assay 48 hrs Antiproliferative activity against human A549 cells after 48 hrs by MTT assay, IC50<1μM. 28511910
QSG7701 Antiproliferative assay 48 hrs Antiproliferative activity against human QSG7701 cells after 48 hrs by MTT assay, IC50<1μM. 28511910
HeLa Antiproliferative assay 48 hrs Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay, IC50=3.8μM. 28511910
HepG2 Antiproliferative assay 48 hrs Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay, IC50=4.92μM. 28511910
WI38 Cytotoxicity assay 48 hrs Cytotoxicity against human WI38 cells after 48 hrs by WST-1 assay, IC50=0.03μM. 28557449
HeLa Cytotoxicity assay 48 hrs Cytotoxicity against human HeLa cells after 48 hrs by WST-1 assay, IC50=0.08μM. 28557449
HCT15 Antiproliferative assay 72 hrs Antiproliferative activity against human HCT15 cells after 72 hrs by CCK8 assay, IC50=0.76μM. 28633898
T47D Antiproliferative assay 72 hrs Antiproliferative activity against human T47D cells after 72 hrs by CCK8 assay, IC50=2.31μM. 28633898
HeLa Antiproliferative assay 72 hrs Antiproliferative activity against human HeLa cells after 72 hrs by CCK8 assay, IC50=2.62μM. 28633898
MIAPaCa2 Antiproliferative assay 48 hrs Antiproliferative activity against human MIAPaCa2 cells after 48 hrs in presence of type 1 collagen coated surface by MTT assay, IC50=0.18μM. 28689976
PC3 Growth inhibition assay 24 hrs Growth inhibition of human PC3 cells up to 25 uM cotreated with colchicine measured after 24 hrs by XTT assay 28710962
MDA-MB-231 Growth inhibition assay 24 hrs Growth inhibition of human MDA-MB-231 cells up to 25 uM cotreated with colchicine measured after 24 hrs by XTT assay 28710962
WM266.4 Growth inhibition assay 24 hrs Growth inhibition of human WM266.4 cells up to 25 uM cotreated with colchicine measured after 24 hrs by XTT assay 28710962
A172 Growth inhibition assay 24 hrs Growth inhibition of human A172 cells up to 25 uM cotreated with colchicine measured after 24 hrs by XTT assay 28710962
NCI-H1299 Growth inhibition assay 24 hrs Growth inhibition of human NCI-H1299 cells up to 25 uM cotreated with colchicine measured after 24 hrs by XTT assay 28710962
RD Cytotoxicity assay 72 hrs Cytotoxicity in human RD cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay, IC50=4.49μM. 28923382
A549 Cytotoxicity assay 72 hrs Cytotoxicity in human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay, IC50=8.87μM. 28923382
HCT16 Cytotoxicity assay 72 hrs Cytotoxicity in human HCT16 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay, IC50=12.34μM. 28923382
MCF7 Cytotoxicity assay 72 hrs Cytotoxicity in human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay, IC50=13.62μM. 28923382
TE32 Cytotoxicity assay 72 hrs Cytotoxicity against human TE32 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay, IC50=1.24μM. 28923388
MS Cytotoxicity assay 72 hrs Cytotoxicity against human MS cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay, IC50=1.84μM. 28923388
HCT116 Cytotoxicity assay 72 hrs Cytotoxicity against human HCT116 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay, IC50=1.88μM. 28923388
Hep2 Cytotoxicity assay 72 hrs Cytotoxicity against human Hep2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay, IC50=3.04μM. 28923388
A549 Cytotoxicity assay 72 hrs Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay, IC50=5.93μM. 28923388
A549 Cytotoxicity assay 72 hrs Cytotoxicity against human A549 cells after 72 hrs by SRB assay, IC50=0.00863μM. 28927790
KBVIN Cytotoxicity assay 72 hrs Cytotoxicity against human KBVIN cells after 72 hrs by SRB assay, IC50=0.0157μM. 28927790
KB Cytotoxicity assay 72 hrs Cytotoxicity against human KB cells after 72 hrs by SRB assay, IC50=0.05μM. 28927790
MCF7 Cytotoxicity assay 72 hrs Cytotoxicity against human MCF7 cells after 72 hrs by SRB assay, IC50=0.0875μM. 28927790
MDA-MB-231 Cytotoxicity assay 72 hrs Cytotoxicity against human MDA-MB-231 cells after 72 hrs by SRB assay, IC50=0.307μM. 28927790
HL60 Antiproliferative assay 72 hrs Antiproliferative activity against human HL60 cells after 72 hrs by tryphan blue staining based hematocytometric method, IC50=0.92μM. 29131616
HL60 Cytotoxicity assay 48 hrs Cytotoxicity against human HL60 cells assessed as reduction in cell viability after 48 hrs by ATPlite-based luminescent assay, IC50=0.02μM. 29223099
HL60 Apoptosis assay 24 hrs Induction of apoptosis in human HL60 cells assessed as caspase 3/7 activity after 24 hrs by caspase-glo luminescent assay, IC50=0.07μM. 29223099
K562 Cytotoxicity assay 48 hrs Cytotoxicity against human K562 cells assessed as reduction in cell viability after 48 hrs by ATPlite-based luminescent assay, IC50=0.09μM. 29223099
MCF7 Cytotoxicity assay 48 hrs Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by ATPlite-based luminescent assay, IC50=0.34μM. 29223099
PC3 Cytotoxicity assay 48 hrs Cytotoxicity against human PC3 cells assessed as reduction in cell viability after 48 hrs by ATPlite-based luminescent assay, IC50=0.4μM. 29223099
HepG2 Cytotoxicity assay 48 hrs Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by ATPlite-based luminescent assay, IC50=0.43μM. 29223099
K562 Apoptosis assay 24 hrs Induction of apoptosis in human K562 cells assessed as caspase 3/7 activity after 24 hrs by caspase-glo luminescent assay, IC50=0.711μM. 29223099
HepG2 Apoptosis assay 24 hrs Induction of apoptosis in human HepG2 cells assessed as caspase 3/7 activity after 24 hrs by caspase-glo luminescent assay, IC50=4.37μM. 29223099
RPE1 Apoptosis assay 24 hrs Induction of apoptosis in human RPE1 cells assessed as caspase 3/7 activity after 24 hrs by caspase-glo luminescent assay, IC50=27.2μM. 29223099
HCT15 Antiproliferative assay 72 hrs Antiproliferative activity against human HCT15 cells incubated for 72 hrs by CCK8 assay, IC50=0.05μM. 29402741
T47D Antiproliferative assay 72 hrs Antiproliferative activity against human T47D cells incubated for 72 hrs by CCK8 assay, IC50=0.07μM. 29402741
HeLa Antiproliferative assay 72 hrs Antiproliferative activity against human HeLa cells incubated for 72 hrs by CCK8 assay, IC50=1.37μM. 29402741
HeLa Antiproliferative assay 24 hrs Antiproliferative activity against human HeLa cells after 24 hrs by crystal violet staining-based assay, IC50=0.94μM. 29407986
CaSki Antiproliferative assay 24 hrs Antiproliferative activity against human CaSki cells after 24 hrs by crystal violet staining-based assay, IC50=1.8μM. 29407986
ViBo Antiproliferative assay 24 hrs Antiproliferative activity against human ViBo cells after 24 hrs by crystal violet staining-based assay, IC50=1.92μM. 29407986
HEK293 Antiproliferative assay 48 hrs Antiproliferative activity against human HEK293 cells after 48 hrs by CCK-8 assay, IC50=0.00056μM. 29501943
A549 Antiproliferative assay 48 hrs Antiproliferative activity against human A549 cells after 48 hrs by CCK-8 assay, IC50=0.001μM. 29501943
SKOV3 Antiproliferative assay 48 hrs Antiproliferative activity against human SKOV3 cells after 48 hrs by CCK-8 assay, IC50=0.0055μM. 29501943
HCT15 Antiproliferative assay 72 hrs Antiproliferative activity against human HCT15 cells after 72 hrs by CCK-8 assay, IC50=0.02μM. 29510948
HeLa Antiproliferative assay 72 hrs Antiproliferative activity against human HeLa cells after 72 hrs by CCK-8 assay, IC50=0.13μM. 29510948
T47D Antiproliferative assay 72 hrs Antiproliferative activity against human T47D cells after 72 hrs by CCK-8 assay, IC50=0.49μM. 29510948
H460 Cytotoxicity assay 72 hrs Cytotoxicity against human H460 cells assessed as reduction in cell viability after 72 hrs by MTT assay, IC50=0.11μM. 29541373
MCF7 Cytotoxicity assay 72 hrs Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay, IC50=0.16μM. 29541373
MDA-MB-231 Cytotoxicity assay 72 hrs Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by MTT assay, IC50=0.54μM. 29541373
CCRF-CEM Cytotoxicity assay 72 hrs Cytotoxicity against human CCRF-CEM cells assessed as growth inhibition after 72 hrs by MTT assay, GI50=0.002μM. 29705710
A549 Cytotoxicity assay 72 hrs Cytotoxicity against human A549 cells assessed as growth inhibition after 72 hrs by MTT assay, GI50=0.003μM. 29705710
HuH7 Cytotoxicity assay 72 hrs Cytotoxicity against human HuH7 cells assessed as growth inhibition after 72 hrs by MTT assay, GI50=0.006μM. 29705710
HCT116 Cytotoxicity assay 72 hrs Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by MTT assay, GI50=0.009μM. 29705710
DU145 Cytotoxicity assay 72 hrs Cytotoxicity against human DU145 cells assessed as growth inhibition after 72 hrs by MTT assay, GI50=0.019μM. 29705710
HCT116 Cytotoxicity assay 72 hrs Cytotoxicity against human HCT116 cells expressing TOP1 siRNA assessed as growth inhibition after 72 hrs by MTT assay, GI50=0.075μM. 29705710
RC0.1 Cytotoxicity assay 72 hrs Cytotoxicity against human RC0.1 cells assessed as growth inhibition after 72 hrs by MTT assay, GI50=7.53μM. 29705710
THP1 Cytotoxicity assay 24 hrs Cytotoxicity against human THP1 cells after 24 hrs by LDH release assay, LD50=0.161μM. 29773506
PANC1 Cytotoxicity assay 72 hrs Cytotoxicity against human PANC1 cells after 72 hrs by XTT assay, IC50=0.09μM. 30017114
PANC1 Cytotoxicity assay 48 hrs Cytotoxicity against human PANC1 cells after 48 hrs by XTT assay, IC50=0.18μM. 30017114
Capan1 Cytotoxicity assay 72 hrs Cytotoxicity against human Capan1 cells after 72 hrs by XTT assay, IC50=0.21μM. 30017114
CNE2 Cytotoxicity assay 48 hrs Cytotoxicity against human CNE2 cells assessed as reduction in cell viability after 48 hrs by MTT assay, IC50=0.1μM. 30025344
A549 Cytotoxicity assay 48 hrs Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay, IC50=5.5μM. 30025344
HepG2 Cytotoxicity assay 48 hrs Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay, IC50=13.2μM. 30025344
K562 Antiproliferative assay 48 hrs Antiproliferative activity against human K562 cells after 48 hrs by MTT assay, IC50=0.07μM. 30055465
HepG2 Antiproliferative assay 48 hrs Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay, IC50=0.37μM. 30055465
CNE1 Antiproliferative assay 72 hrs Antiproliferative activity against human CNE1 cells after 72 hrs by MTT assay, IC50=0.34μM. 30125725
MCF7 Antiproliferative assay 72 hrs Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay, IC50=0.42μM. 30125725
HeLa Antiproliferative assay 72 hrs Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay, IC50=0.66μM. 30125725
CNE2 Antiproliferative assay 72 hrs Antiproliferative activity against human CNE2 cells after 72 hrs by MTT assay, IC50=0.98μM. 30125725
SMMC7721 Antiproliferative assay 72 hrs Antiproliferative activity against human SMMC7721 cells after 72 hrs by MTT assay, IC50=1.08μM. 30125725
HepG2 Antiproliferative assay 72 hrs Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay, IC50=1.36μM. 30125725
HepG2 Antiproliferative assay 48 hrs Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay, IC50=6.08μM. 30125725
HCT15 Antiproliferative assay 72 hrs Antiproliferative activity against human HCT15 cells after 72 hrs by EZ-CYTOX reagent based assay, IC50=0.05μM. 30262132
T47D Antiproliferative assay 72 hrs Antiproliferative activity against human T47D cells after 72 hrs by EZ-CYTOX reagent based assay, IC50=0.07μM. 30262132
HeLa Antiproliferative assay 72 hrs Antiproliferative activity against human HeLa cells after 72 hrs by EZ-CYTOX reagent based assay, IC50=1.37μM. 30262132
CCRF-CEM Growth inhibition assay 72 hrs Growth inhibition of human CCRF-CEM cells after 72 hrs by MTT assay, GI50=0.007μM. 30336023
HCT116 Growth inhibition assay 72 hrs Growth inhibition of human HCT116 cells after 72 hrs by MTT assay, GI50=0.009μM. 30336023
DU145 Growth inhibition assay 72 hrs Growth inhibition of human DU145 cells after 72 hrs by MTT assay, GI50=0.021μM. 30336023
HCT116 Growth inhibition assay 72 hrs Growth inhibition of human HCT116 cells expressing TOP1 siRNA after 72 hrs by MTT assay, GI50=0.075μM. 30336023
HuH7 Growth inhibition assay 72 hrs Growth inhibition of human HuH7 cells after 72 hrs by MTT assay, GI50=0.099μM. 30336023
A549 Growth inhibition assay 72 hrs Growth inhibition of human A549 cells after 72 hrs by MTT assay, GI50=0.21μM. 30336023
RC0.1 Growth inhibition assay 72 hrs Growth inhibition of human RC0.1 cells after 72 hrs by MTT assay, GI50=4.73μM. 30336023
MCF7 Cytotoxicity assay 72 hrs Cytotoxicity against against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay, IC50=0.04μM. 30340899
MS Cytotoxicity assay 72 hrs Cytotoxicity against against human MS cells assessed as reduction in cell viability after 72 hrs by MTT assay, IC50=0.77μM. 30340899
A549 Cytotoxicity assay 72 hrs Cytotoxicity against against human A549 cells assessed as reduction in cell viability after 72 hrs by MTT assay, IC50=1.31μM. 30340899
HEK293 Cytotoxicity assay 72 hrs Cytotoxicity against HEK293 cells assessed as reduction in cell viability after 72 hrs by MTT assay, IC50=1.61μM. 30340899
RD Cytotoxicity assay 72 hrs Cytotoxicity against against human RD cells assessed as reduction in cell viability after 72 hrs by MTT assay, IC50=1.72μM. 30340899
HCT116 Cytotoxicity assay 72 hrs Cytotoxicity against against human HCT116 cells assessed as reduction in cell viability after 72 hrs by MTT assay, IC50=1.88μM. 30340899
Hep2 Cytotoxicity assay 72 hrs Cytotoxicity against against human Hep2 cells assessed as reduction in cell viability after 72 hrs by MTT assay, IC50=3.01μM. 30340899
HL60 Cytotoxicity assay 48 hrs Cytotoxicity against human HL60 cells after 48 hrs by MTT assay, IC50<0.064μM. 30509782
A549 Cytotoxicity assay 48 hrs Cytotoxicity against human A549 cells after 48 hrs by MTT assay, IC50=0.09μM. 30509782
SW480 Cytotoxicity assay 48 hrs Cytotoxicity against human SW480 cells after 48 hrs by MTT assay, IC50=0.29μM. 30509782
SMMC7721 Cytotoxicity assay 48 hrs Cytotoxicity against human SMMC7721 cells after 48 hrs by MTT assay, IC50=0.45μM. 30509782
MCF7 Cytotoxicity assay 48 hrs Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay, IC50=0.68μM. 30509782
HepG2 Cytotoxicity assay 72 hrs Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay, IC50=0.66μM. 30600208
MCF7 Cytotoxicity assay 72 hrs Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay, IC50=0.68μM. 30600208
MGC803 Antiproliferative assay 48 hrs Antiproliferative activity against human MGC803 cells after 48 hrs by MTT assay, IC50=2.96μM. 30685528
A549 Antiproliferative assay 48 hrs Antiproliferative activity against human A549 cells after 48 hrs by MTT assay, IC50=4.43μM. 30685528
HepG2 Antiproliferative assay 48 hrs Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay, IC50=4.79μM. 30685528
HeLa Antiproliferative assay 48 hrs Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay, IC50=6.51μM. 30685528
T24 Antiproliferative assay 48 hrs Antiproliferative activity against human T24 cells after 48 hrs by MTT assay, IC50=6.8μM. 30685528
WI38 Antiproliferative assay 48 hrs Antiproliferative activity against human WI38 cells after 48 hrs by MTT assay, IC50=8.37μM. 30685528
A549 Cytotoxicity assay 48 hrs Cytotoxicity against human A549 cells after 48 hrs by CCK8 assay, IC50=0.00032μM. 30702286
LN229 Cytotoxicity assay 48 hrs Cytotoxicity against human LN229 cells after 48 hrs by CCK8 assay, IC50=0.00032μM. 30702286
MHCC97H Cytotoxicity assay 48 hrs Cytotoxicity against human MHCC97H cells after 48 hrs by CCK8 assay, IC50=0.00032μM. 30702286
LoVo Cytotoxicity assay 48 hrs Cytotoxicity against human LoVo cells after 48 hrs by CCK8 assay, IC50=0.00032μM. 30702286
MDA231 Cytotoxicity assay 48 hrs Cytotoxicity against human MDA231 cells after 48 hrs by CCK8 assay, IC50=0.00032μM. 30702286
HuH7 Cytotoxicity assay 48 hrs Cytotoxicity against human HuH7 cells after 48 hrs by CCK8 assay, IC50=0.00032μM. 30702286
MGC Cytotoxicity assay 48 hrs Cytotoxicity against human MGC cells after 48 hrs by CCK8 assay, IC50=0.00032μM. 30702286
HL7702 Cytotoxicity assay 48 hrs Cytotoxicity against human HL7702 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay, IC50=2.15μM. 30875505
T24 Antiproliferative assay 48 hrs Antiproliferative activity against human T24 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay, IC50=3.09μM. 30875505
MGC803 Antiproliferative assay 48 hrs Antiproliferative activity against human MGC803 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay, IC50=4.27μM. 30875505
NCI-H460 Antiproliferative assay 48 hrs Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay, IC50=5.37μM. 30875505
HepG2 Antiproliferative assay 48 hrs Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay, IC50=5.69μM. 30875505
Sf9 Function assay 30 mins Poison activity at recombinant human TOP1 expressed in baculovirus infected Sf9 insect cells assessed as decrease in relaxed supercoiled pBS(SK+) DNA mobility measured after 30 mins by ethidium bromide staining based agarose gel electrophoresis, IC50=0.025μM. 30897325
MCF7 Function assay 30 mins Poison activity at TOP1 in human MCF7 cells assessed as decrease in relaxed supercoiled pBS(SK+) DNA mobility measured after 30 mins by ethidium bromide staining based agarose gel electrophoresis, IC50=2.5μM. 30897325
A549 Cytotoxicity assay 72 hrs Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay, IC50=3.32μM. 30902399
HCT116 Growth inhibition assay 72 hrs Growth inhibition of human HCT116 cells incubated for 72 hrs by MTT assay, GI50=0.009μM. 31176097
MCF7 Growth inhibition assay 72 hrs Growth inhibition of human MCF7 cells incubated for 72 hrs by MTT assay, GI50=0.012μM. 31176097
HCT116 Growth inhibition assay 72 hrs Growth inhibition of human HCT116 cells expressing siTOP1 incubated for 72 hrs by MTT assay, GI50=0.075μM. 31176097
A549 Growth inhibition assay 72 hrs Growth inhibition of human A549 cells incubated for 72 hrs by MTT assay, GI50=0.099μM. 31176097
DU145 Growth inhibition assay 72 hrs Growth inhibition of human DU145 cells incubated for 72 hrs by MTT assay, GI50=0.21μM. 31176097
DU145/RC0.1 Growth inhibition assay 72 hrs Growth inhibition of human DU145/RC0.1 cells harboring TOP1 R364H mutant incubated for 72 hrs by MTT assay, GI50=4.73μM. 31176097
A549 Antiproliferative assay 48 hrs Antiproliferative activity against human A549 cells incubated for 48 hrs by CCK8 assay, IC50=0.001μM. 31229877
SKOV3 Antiproliferative assay 48 hrs Antiproliferative activity against human SKOV3 cells incubated for 48 hrs by CCK8 assay, IC50=0.0055μM. 31229877
HCC70 Antiproliferative assay 72 hrs Antiproliferative activity against human HCC70 cells measured after 72 hrs by Ez-cytox assay, IC50=0.044μM. 31398033
HCT15 Antiproliferative assay 72 hrs Antiproliferative activity against human HCT15 cells measured after 72 hrs by EZ-Cytox assay, IC50=0.049μM. 31398033
DU145 Antiproliferative assay 72 hrs Antiproliferative activity against human DU145 cells measured after 72 hrs by EZ-Cytox assay, IC50=0.05μM. 31398033
T47D Antiproliferative assay 72 hrs Antiproliferative activity against human T47D cells measured after 72 hrs by EZ-Cytox assay, IC50=0.25μM. 31398033
HeLa Antiproliferative assay 72 hrs Antiproliferative activity against human HeLa cells measured after 72 hrs by EZ-Cytox assay, IC50=0.5μM. 31398033
MDA-MB-231 Antiproliferative assay 72 hrs Antiproliferative activity against human MDA-MB-231 cells measured after 72 hrs by Ez-cytox assay, IC50=23.98μM. 31398033
MDA-MB-436 Antiproliferative assay 72 hrs Antiproliferative activity against human MDA-MB-436 cells measured after 72 hrs by Ez-cytox assay, IC50=31.86μM. 31398033
MCF7 Antiproliferative assay 48 hrs Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by SRB assay, IC50=0.03μM. 31546197
A549 Antiproliferative assay 48 hrs Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 48 hrs by SRB assay, IC50=0.03μM. 31546197
HCT116 Antiproliferative assay 48 hrs Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability after 48 hrs by SRB assay, IC50=0.03μM. 31546197
HT-29 Antiproliferative assay 48 hrs Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability after 48 hrs by SRB assay, IC50=0.03μM. 31546197
MV-3 Antiproliferative assay 72 hrs Antiproliferative activity against human MV-3 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay, IC50=0.003μM. 31880942
K562 Antiproliferative assay 72 hrs Antiproliferative activity against human K562 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay, IC50<0.003μM. 31880942
HCT116 Antiproliferative assay 72 hrs Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay, IC50=0.02μM. 31880942
Bel7404 Antiproliferative assay 72 hrs Antiproliferative activity against human Bel7404 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay, IC50=0.4μM. 31880942
SW579 Antiproliferative assay 72 hrs Antiproliferative activity against human SW579 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay, IC50=0.7μM. 31880942
SKHEP1 Antiproliferative assay 72 hrs Antiproliferative activity against human SKHEP1 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay, IC50=0.9μM. 31880942
PC3 Antiproliferative assay 72 hrs Antiproliferative activity against human PC3 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay, IC50=2.4μM. 31880942
MDA-MB-435 Antiproliferative assay 72 hrs Antiproliferative activity against human MDA-MB-435 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay, IC50=2.7μM. 31880942
A549 Antiproliferative assay 72 hrs Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay, IC50=2.8μM. 31880942
HCT116 Antiproliferative assay 4 days Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability after 4 days by [3H]-thymidine incorporation assay, IC50=0.0085μM. ChEMBL
786-O Antiproliferative assay 72 hrs Antiproliferative activity against human 786-O cells incubated for 72 hrs by MTT assay, IC50=0.015μM. ChEMBL
MDA-MB-231 Antiproliferative assay 4 days Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 4 days by [3H]-thymidine incorporation assay, IC50=0.0284μM. ChEMBL
HeLa Antiproliferative assay 72 hrs Antiproliferative activity against human HeLa cells incubated for 72 hrs by MTT assay, IC50=0.18μM. ChEMBL
MIAPaCa2 Antiproliferative assay 48 hrs Antiproliferative activity against human MIAPaCa2 cells assessed as cell viability after 48 hrs by MTT assay, IC50=0.19μM. ChEMBL
HepG2 Antiproliferative assay 48 hrs Antiproliferative activity against human HepG2 cells assessed as cell viability after 48 hrs by MTT assay, IC50=0.2μM. ChEMBL
SKHep Antiproliferative assay 72 hrs Antiproliferative activity against human SKHep cells incubated for 72 hrs by MTT assay, IC50=0.22μM. ChEMBL
HL60 Cytotoxicity assay 48 hrs Cytotoxicity against human HL60 cells after 48 hrs by MTT assay, IC50=0.42μM. ChEMBL
Detroit 551 Antiproliferative assay 72 hrs Antiproliferative activity against human Detroit 551 cells incubated for 72 hrs by MTT assay, IC50=0.99μM. ChEMBL
PC3 Antiproliferative assay 48 hrs Antiproliferative activity against human PC3 cells assessed as cell viability after 48 hrs by MTT assay, IC50=1.2μM. ChEMBL
MDA-MB-231 Antiproliferative assay 72 hrs Antiproliferative activity against human MDA-MB-231 cells incubated for 72 hrs by MTT assay, IC50=2.11μM. ChEMBL
A549 Cytotoxicity assay 48 hrs Cytotoxicity against human A549 cells after 48 hrs by MTT assay, IC50=2.21μM. ChEMBL
H1299 Antiproliferative assay 72 hrs Antiproliferative activity against human H1299 cells incubated for 72 hrs by MTT assay, IC50=3.14μM. ChEMBL
Raji Cytotoxicity assay 48 hrs Cytotoxicity against human Raji cells after 48 hrs by MTT assay, IC50=3.27μM. ChEMBL
SAS Antiproliferative assay 72 hrs Antiproliferative activity against human SAS cells incubated for 72 hrs by MTT assay, IC50=6μM. ChEMBL
MDA-MB-231 Cytotoxicity assay 48 hrs Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay, IC50=16.44μM. ChEMBL
PC3 Cytotoxicity assay 48 hrs Cytotoxicity against human PC3 cells after 48 hrs by MTT assay, IC50=18.24μM. ChEMBL
AGS Antiproliferative assay 72 hrs Antiproliferative activity against human AGS cells incubated for 72 hrs by MTT assay, IC50=23.76μM. ChEMBL
A549 Apoptosis assay 12 to 15 hrs Induction of apoptosis in human A549 cells assessed as formation of apoptotic bodies after 12 to 15 hrs by flow cytometric method ChEMBL
A549 Apoptosis assay 12 to 15 hrs Induction of apoptosis in human A549 cells assessed as cell condensation after 12 to 15 hrs by flow cytometric method ChEMBL
HT-29 cytotoxicity assay IC50=1.4 μM 12639541
JLC cytotoxicity assay IC50=5.6 nM 12620081
Lewis cytotoxicity assay IC50=33 nM 12620081
P388 cytotoxicity assay IC50=13 nM 12620081
A2780 cytotoxicity assay IC50=4 nM 11858737
HCT116 cytotoxicity assay IC50=9 nM 11858737
LX-1 cytotoxicity assay IC50=120 nM 11858737
SK-BR-3 cytotoxicity assay IC50=20 nM 11334569
H128 cytotoxicity assay IC50=18 nM 11334569
SK-OV-3 cytotoxicity assay IC50=20 nM 11334569
MKN45 cytotoxicity assay IC50=17 nM 11334569
A549 cytotoxicity assay IC50=14 nM 11334569
WiDr cytotoxicity assay IC50=17 nM 11334569
MDA-MB-435 Growth inhibitory assay IC50=40 nM 11020283
DU-145 Growth inhibitory assay IC50=10 nM 11020283
SN12C Growth inhibitory assay IC50=20 nM 11020283
OVCAR-3 Growth inhibitory assay IC50=220 nM 11020283
UACC-62 Growth inhibitory assay IC50=10 nM 11020283
SF-539 Growth inhibitory assay IC50=10 nM 11020283
HCT-116 Growth inhibitory assay IC50=30 nM 11020283
HOP-62 Growth inhibitory assay IC50=10 nM 11020283
T24 cytotoxicity assay IC50=88 nM 10841808
A549 cytotoxicity assay IC50=67 nM 10841808
HT29 cytotoxicity assay IC50=80 nM 10841808
KBCamp Growth inhibitory assay IC50=1.04 μM 10411476
KB7D Growth inhibitory assay IC50=35 nM 10411476
KBV20C Growth inhibitory assay IC50=30 nM 10411476
KBMDR Growth inhibitory assay IC50=70 nM 10411476
KBwt Growth inhibitory assay IC50=40 nM 10411476
P388CPT5 R Growth inhibitory assay IC50=2.8 μM 10346933
P388 Growth inhibitory assay IC50=32 nM 10346933
Caki-2 cytotoxicity assay IC50=3.96 μM 12639541
A549 cytotoxicity assay IC50=2.53 μM 12639541
HEC-1-B cytotoxicity assay IC50=8.64 μM 12639541
HL-60 cytotoxicity assay IC50=66 nM 12639541
MT-4 cytotoxicity assay IC50=4 nM 17254669
CCRF-CEMc cytotoxicity assay IC50=3 nM 17254669
WIL-2NSd cytotoxicity assay IC50=5 nM 17254669
CCRF-SB cytotoxicity assay IC50=3 nM 17254669
CRL 7065 cytotoxicity assay IC50=400 nM 17254669
SK-MEL-28b cytotoxicity assay IC50=40 nM 17254669
MCF-7 cytotoxicity assay IC50=40 nM 17254669
SKMES-1 cytotoxicity assay IC50=10 nM 17254669
HepG2 cytotoxicity assay IC50=30 nM 17254669
DU145 cytotoxicity assay IC50=10 nM 17254669
SKOV3 cytotoxicity assay IC50=51 nM 9003520
SKVLB cytotoxicity assay IC50=53 nM 9003520
HT29 cytotoxicity assay IC50=87.8 nM 9003520
KB cytotoxicity assay IC50=8 nM 9003520
L1210 Function assay Concentration that inhibits the proliferation of L1210 cells by 50%, IC50=0.014μM. 2537428
SK-OV-3 Cytotoxicity assay Cytotoxicity was determined in vitro in SK-OV-3 cells (ovarian) of human tumor cell lines by using MTT assay, IC50=0.037μM. 7853331
SKVLB Cytotoxicity assay Cytotoxicity was determined in vitro in SKVLB cells(ovarian with upregulated MDRp-glycoprotein) of human tumor cell lines by using MTT assay, IC50=0.041μM. 7853331
HT-29 Cytotoxicity assay Cytotoxicity was determined in vitro in HT-29 cells(colon) of human tumor cell lines by using MTT assay, IC50=0.046μM. 7853331
LOX Cytotoxicity assay Cytotoxicity was determined in vitro in LOX cells (melanoma) of human tumor cell lines by using MTT assay, IC50=0.048μM. 7853331
T47D Cytotoxicity assay Cytotoxicity was determined in vitro in T47D cells(breast) of human tumor cell lines by using MTT assay, IC50=0.207μM. 7853331
L1210 Cytotoxicity assay Cytotoxicity was measured on cultured murine lymphoblastic leukemia cells (L1210), IC50=0.015μM. 8246238
HL-60 Function assay Inhibition of Topoisomerase I by cleavage complex formation in human HL-60 cells, IC50=0.68μM. 8410981
KB Growth inhibition assay Compound concentration required to reduce the exponential growth of KB cells by 50%, CC50=0.006μM. 9767632
MT-4 Growth inhibition assay Compound concentration required to reduce the exponential growth of MT-4 cells by 50%, CC50=0.01μM. 9767632
COLO 205 Cytotoxicity assay Cytotoxicity expressed as the concentration that inhibited incorporation of [3H]thymidine into cellular DNA of human colorectal cells (COLO 205), IC50=0.0054μM. 10479293
HepG2 Cytotoxicity assay Cytotoxicity expressed as the concentration that inhibited incorporation of [3H]thymidine into cellular DNA of human hepatocellular cells (HepG2), IC50=0.0063μM. 10479293
H928 Cytotoxicity assay Cytotoxicity expressed as the concentration that inhibited incorporation of [3H]-thymidine into cellular DNA of human lung carcinoma cells (H928), IC50=0.0078μM. 10479293
CaSki Cytotoxicity assay Cytotoxicity expressed as the concentration that inhibited incorporation of [3H]thymidine into cellular DNA of human cervical cells (CaSki), IC50=0.0085μM. 10479293
MDA-MB-435 Function assay Inhibition against MDA-MB-435 human breast cancer cells in the absence of HSA, IC50=0.015μM. 11052802
MDA-MB-435 Function assay Inhibition against MDA-MB-435 human breast cancer cells in the presence of 11 mg/mL HSA, IC50=0.375μM. 11052802
Jurkat Function assay Inhibitory activity against Jurkat human leukemia cells, IC50=0.0056μM. 11384245
P388 Function assay Inhibitory activity against P388 murine leukemia cells, IC50=0.013μM. 11384245
Lewis lung carcinoma cells Function assay Inhibitory activity against Lewis lung carcinoma cells, IC50=0.033μM. 11384245
A549 Function assay Inhibition topoisomerase 1 in human A549 cells assessed as conversion of supercoiled pBR322 DNA to relaxed form, IC50=4μM. 11430001
HeLa Function assay Inhibition topoisomerase 1 in human HeLa cells assessed as conversion of supercoiled pBR322 DNA to relaxed form, IC50=9μM. 11430001
NIH/3T3 Function assay Inhibition topoisomerase 1 in mouse NIH/3T3 cells assessed as conversion of supercoiled pBR322 DNA to relaxed form, IC50=12μM. 11430001
COLO201 Function assay Inhibition topoisomerase 1 in human COLO201 cells assessed as conversion of supercoiled pBR322 DNA to relaxed form, IC50=17μM. 11430001
Vero Function assay Inhibition topoisomerase 1 in african green monkey Vero cells assessed as conversion of supercoiled pBR322 DNA to relaxed form, IC50=27μM. 11430001
SW626 Cytotoxicity assay Cytotoxicity against human SW626 cells by MTT assay, IC50=0.0287μM. 11858760
Lu1 Cytotoxicity assay Cytotoxicity against human Lu1 cells by MTT assay, IC50=0.0287μM. 11858760
KB Cytotoxicity assay Cytotoxicity against human KB cells by MTT assay, IC50=0.0287μM. 11858760
HOG.R5 Cytotoxicity assay Cytotoxicity against human HOG.R5 cells by MTT assay, IC50=0.0287μM. 11858760
LNCAP Cytotoxicity assay Cytotoxicity against human LNCAP cells by MTT assay, IC50=0.0861μM. 11858760
HCT116 Function assay Compound was tested in vitro for cytotoxicity against HCT116, human colon cancer cells (taxol-resistant) at a drug concentration producing 50% inhibition of colony formation, ID50=0.0028μM. 11965362
PC-3 Function assay Compound was tested in vitro for cytotoxicity against PC-3, human prostate cancer cells (taxol-sensitive) at a drug concentration producing 50% inhibition of colony formation, ID50=0.0038μM. 11965362
MCF-7ADR Function assay Compound was tested in vitro for cytotoxicity against MCF-7ADR, human breast cancer cells (taxol-resistant) at a drug concentration producing 50% inhibition of colony formation, ID50=0.0039μM. 11965362
L1210 Function assay Inhibitory concentration required against L1210 leukemia cells, IC50=0.03μM. 12182872
L1210 Cytotoxicity assay Cytotoxicity against L1210 leukemia cells, Concentration=0.05μM. 12182872
P388 Function assay Inhibitory activity against P388 Leukemia cells, IC50=0.007μM. 12565975
CCRF-CEM Cytotoxicity assay Cytotoxicity in human leukemic CCRF-CEM cells, IC50=5.3μM. 14667232
HeLa Function assay Concentration required to inhibit S phase and G2/M phase in HeLa cells, Concentration=0.1μM. 15026047
HeLa Growth inhibition assay Growth inhibitory concentration of compound was determined against HeLa cells by alamar blue assay, GI50=0.6μM. 15026047
SW620 Growth inhibition assay Concentration required to inhibit growth of SW620 (human colon cancer) cells in the presence of 10 uM of Compound 2e, EC50=0.00015μM. 15857116
SW620 Growth inhibition assay Concentration required to inhibit growth of SW620 (human colon cancer) cells, EC50=0.0012μM. 15857116
CNSSF-539 Growth inhibition assay Concentration required to inhibit the growth of human CNSSF-539 cells, GI50=0.01μM. 16033260
LungHOP-62 Growth inhibition assay Concentration required to inhibit the growth of human LungHOP-62 cells, GI50=0.01μM. 16033260
ProstateDU-145 Growth inhibition assay Concentration required to inhibit the growth of human ProstateDU-145 cells, GI50=0.01μM. 16033260
Melanoma UACC-62 Growth inhibition assay Concentration required to inhibit the growth of human Melanoma UACC-62 cells, GI50=0.01μM. 16033260
Renal SN12C Growth inhibition assay Concentration required to inhibit the growth of human Renal SN12C cells, GI50=0.02μM. 16033260
ColonHCT-11 Growth inhibition assay Concentration required to inhibit the growth of human ColonHCT-11 cells, GI50=0.03μM. 16033260
MDA-MB-435 Growth inhibition assay Concentration required to inhibit the growth of human Breast MDA-MB-435 cells, GI50=0.04μM. 16033260
OVCAR Growth inhibition assay Concentration required to inhibit the growth of human OvarianOVCAR cells, GI50=0.22μM. 16033260
T24 Growth inhibition assay Growth inhibition of human T24 cells by neutral red assay, IC50=0.006μM. 17204425
HT29 Growth inhibition assay Growth inhibition of human HT29 cells by neutral red assay, IC50=0.014μM. 17204425
MDA-MB-231 Growth inhibition assay Growth inhibition of human MDA-MB-231 cells by neutral red assay, IC50=0.291μM. 17204425
SW620 Antiproliferative assay Antiproliferative activity against human SW620 cells by soft agar assay, EC50=0.0021μM. 17287122
LNCAP Cytotoxicity assay Cytotoxicity against human LNCAP cells by sulforhodamine B assay, ED50=0.002μM. 17350834
1A9 Cytotoxicity assay Cytotoxicity against human 1A9 cells by sulforhodamine B assay, ED50=0.0032μM. 17350834
MCF7 Cytotoxicity assay Cytotoxicity against human MCF7 cells by sulforhodamine B assay, ED50=0.0032μM. 17350834
A549 Cytotoxicity assay Cytotoxicity against human A549 cells by sulforhodamine B assay, ED50=0.0069μM. 17350834
DU145 Cytotoxicity assay Cytotoxicity against human DU145 cells by sulforhodamine B assay, ED50=0.0109μM. 17350834
KBVIN Cytotoxicity assay Cytotoxicity against multi drug-resistant human KBVIN cells by sulforhodamine B assay, ED50=0.015μM. 17350834
PC3 Cytotoxicity assay Cytotoxicity against human PC3 cells by sulforhodamine B assay, ED50=0.0167μM. 17350834
KB Cytotoxicity assay Cytotoxicity against human KB cells by sulforhodamine B assay, ED50=0.0209μM. 17350834
HOP62 Cytotoxicity assay Cytotoxicity against human HOP62 cells, GI50=0.01μM. 17402722
SF268 Cytotoxicity assay Cytotoxicity against human SF268 cells, GI50=0.01μM. 17402722
UACC62 Cytotoxicity assay Cytotoxicity against human UACC62 cells, GI50=0.01μM. 17402722
DU145 Cytotoxicity assay Cytotoxicity against human DU145 cells, GI50=0.01μM. 17402722
SN12C Cytotoxicity assay Cytotoxicity against human SN12C cells, GI50=0.02μM. 17402722
HCT116 Cytotoxicity assay Cytotoxicity against human HCT116 cells, GI50=0.03μM. 17402722
MDA-MA-435 Cytotoxicity assay Cytotoxicity against human MDA-MA-435 cells, GI50=0.04μM. 17402722
OVCAR-3 Cytotoxicity assay Cytotoxicity against human OVCAR-3 cells, GI50=0.22μM. 17402722
neural precursor cells Function assay Inhibition of neurosphere proliferation of mouse neural precursor cells by MTT assay 17417631
CEM Growth inhibition assay Growth inhibition of human CEM cells by Alamar blue assay, GI50=0.002μM. 17418582
MX2 Growth inhibition assay Growth inhibition of topoisomerase 2 mutated mitoxantrone-resistant MX2 cells by Alamar blue assay, GI50=0.02μM. 17418582
HL60 Growth inhibition assay Growth inhibition of human HL60 cells by Almar blue assay, GI50=0.03μM. 17418582
HL60 Cytotoxicity assay Cytotoxicity against human HL60 cells by MTT assay, IC50=0.018μM. 17498951
Col2 Cytotoxicity assay Cytotoxicity against human Col2 cells by SRB assay, IC50=0.045μM. 17498951
A549 Cytotoxicity assay Cytotoxicity against human A549 cells by SRB assay, IC50=0.069μM. 17498951
HT1080 Cytotoxicity assay Cytotoxicity against human HT1080 cells by SRB assay, IC50=0.08μM. 17498951
SNU638 Cytotoxicity assay Cytotoxicity against human SNU638 cells by SRB assay, IC50=0.098μM. 17498951
HeLa Cytotoxicity assay Cytotoxicity against human HeLa cells by MTT method, IC50=0.5μM. 17547457
KB Cytotoxicity assay Cytotoxicity against human KB cells, EC50=0.0036μM. 17552563
HOP62 Cytotoxicity assay Cytotoxicity against human HOP62 cells, GI50=0.01μM. 17676830
SF539 Cytotoxicity assay Cytotoxicity against human SF539 cells, GI50=0.01μM. 17676830
UACC62 Cytotoxicity assay Cytotoxicity against human UACC62 cells, GI50=0.01μM. 17676830
DU145 Cytotoxicity assay Cytotoxicity against human DU145 cells, GI50=0.01μM. 17676830
SN12C Cytotoxicity assay Cytotoxicity against human SN12C cells, GI50=0.02μM. 17676830
HCT116 Cytotoxicity assay Cytotoxicity against human HCT116 cells, GI50=0.03μM. 17676830
MDA-MB-435 Cytotoxicity assay Cytotoxicity against human MDA-MB-435 cells, GI50=0.04μM. 17676830
OVCAR-3 Cytotoxicity assay Cytotoxicity against human OVCAR-3 cells, GI50=0.22μM. 17676830
HOP62 Cytotoxicity assay Cytotoxicity against human HOP62 cells, GI50=0.01μM. 17696418
SF539 Cytotoxicity assay Cytotoxicity against human SF539 cells, GI50=0.01μM. 17696418
UACC62 Cytotoxicity assay Cytotoxicity against human UACC62 cells, GI50=0.01μM. 17696418
DU145 Cytotoxicity assay Cytotoxicity against human DU145 cells, GI50=0.01μM. 17696418
SN12C Cytotoxicity assay Cytotoxicity against human SN12C cells, GI50=0.02μM. 17696418
HCT116 Cytotoxicity assay Cytotoxicity against human HCT116 cells, GI50=0.03μM. 17696418
MDA-MB-435 Cytotoxicity assay Cytotoxicity against human MDA-MB-435 cells, GI50=0.04μM. 17696418
OVCAR-3 Cytotoxicity assay Cytotoxicity against human OVCAR-3 cells, GI50=0.22μM. 17696418
OV3 Cytotoxicity assay Cytotoxicity against human OV3 cells by SRB assay, IC50=0.024μM. 17827007
A549 Cytotoxicity assay Cytotoxicity against human A549 cells by SRB assay, IC50=0.067μM. 17827007
SK-MEL-2 Cytotoxicity assay Cytotoxicity against human SK-MEL-2 cells by SRB assay, IC50=0.075μM. 17827007
HCT15 Cytotoxicity assay Cytotoxicity against human HCT15 cells by SRB assay, IC50=0.08μM. 17827007
HL60/MX2 Cytotoxicity assay Cytotoxicity against DNA topoisomerase-2 deficient human HL60/MX2 cells by MTT assay, GI50=0.0015μM. 17962028
HL60 Cytotoxicity assay Cytotoxicity against human HL60 cells, IC50=0.013μM. 18178085
HCT116 Cytotoxicity assay Cytotoxicity against human HCT116 cells, IC50=1μM. 18178085
HeLa Cytotoxicity assay Cytotoxicity against human HeLa cells, IC50=1.08μM. 18178085
DU145 Cytotoxicity assay Cytotoxicity against human DU145 cells, IC50=3.2μM. 18178085
MDA-MB-231 Cytotoxicity assay Cytotoxicity against human MDA-MB-231 cells, IC50=4.16μM. 18178085
P388 Cytotoxicity assay Cytotoxicity against human P388 cells, IC50=0.000004μM. 18511275
RPMI-8240 Cytotoxicity assay Cytotoxicity against human RPMI-8240 cells, IC50=0.000004μM. 18511275
HOP62 Antiproliferative assay Antiproliferative activity against human HOP62 cells, GI50=0.01μM. 18630891
SF539 Antiproliferative assay Antiproliferative activity against human SF539 cells, GI50=0.01μM. 18630891
UACC62 Antiproliferative assay Antiproliferative activity against human UACC62 cells, GI50=0.01μM. 18630891
DU145 Antiproliferative assay Antiproliferative activity against human DU145 cells, GI50=0.01μM. 18630891
SN12C Antiproliferative assay Antiproliferative activity against human SN12C cells, GI50=0.02μM. 18630891
HCT116 Antiproliferative assay Antiproliferative activity against human HCT116 cells, GI50=0.03μM. 18630891
MDA-MB-435 Antiproliferative assay Antiproliferative activity against human MDA-MB-435 cells, GI50=0.04μM. 18630891
OVCAR-3 Antiproliferative assay Antiproliferative activity against human OVCAR-3 cells, GI50=0.22μM. 18630891
P388 Cytotoxicity assay Cytotoxicity against mouse P388 cells by MTT method, IC50=0.004μM. 18771930
RPMI8402 Cytotoxicity assay Cytotoxicity against human RPMI8402 cells by MTT method, IC50=0.004μM. 18771930
KB3-1 Cytotoxicity assay Cytotoxicity against human KB3-1 cells by MTT method, IC50=0.015μM. 18771930
KBV1 Cytotoxicity assay Cytotoxicity against human KBV1 cells by MTT method, IC50=0.025μM. 18771930
KBH5.0 Cytotoxicity assay Cytotoxicity against human KBH5.0 cells by MTT method, IC50=0.026μM. 18771930
RPMI8402 Cytotoxicity assay Cytotoxicity against human RPMI8402 cells after MTT assay, IC50=0.006μM. 18829334
P388 Cytotoxicity assay Cytotoxicity against mouse P388 cells after MTT assay, IC50=0.014μM. 18829334
HEPG2 Cytotoxicity assay Cytotoxicity against human HEPG2 cells by MTT assay, IC50=0.3μM. 18841903
HT29 Cytotoxicity assay Cytotoxicity against human HT29 cells by MTT assay, IC50=2μM. 18841903
MCF7 Cytotoxicity assay Cytotoxicity against human MCF7 cells by MTT assay, IC50=10μM. 18841903
RPMI8226 Cytotoxicity assay Cytotoxicity against human RPMI8226 cells by MTT method, IC50=0.006μM. 19012996
P388 Cytotoxicity assay Cytotoxicity against mouse P388 cells by MTT method, IC50=0.014μM. 19012996
A549 Cytotoxicity assay Cytotoxicity against human A549 cells by sulforhodamine B assay, IC50=0.058μM. 19345580
HeLa Cytotoxicity assay Cytotoxicity against human HeLa cells by sulforhodamine B assay, IC50=0.072μM. 19345580
HL60 Cytotoxicity assay Cytotoxicity against human HL60 cells by sulforhodamine B assay, IC50=0.089μM. 19345580
A549/ATCC Antitumor assay Antitumor activity against human A549/ATCC cells by SRB method, IC50=0.047μM. 19541483
HT-29 Antitumor assay Antitumor activity against human HT-29 cells by SRB method, IC50=0.12μM. 19541483
HL60 Cytotoxicity assay Cytotoxicity against human HL60 cells by rapid colorimetric assay, IC50=0.8μM. 19585998
KB Cytotoxicity assay Cytotoxicity against human KB cells by SRB staining-based fluorescence cytometry, IC50=1.22μM. 19653666
HeLa Cytotoxicity assay Cytotoxicity against human HeLa cells by SRB staining-based fluorescence cytometry, IC50=1.22μM. 19653666
HT-29 Cytotoxicity assay Cytotoxicity against human HT-29 cells by SRB staining-based fluorescence cytometry, IC50=1.22μM. 19653666
MCF7 Cytotoxicity assay Cytotoxicity against human MCF7 cells by SRB staining-based fluorescence cytometry, IC50=1.22μM. 19653666
HOP62 Cytotoxicity assay Cytotoxicity against human HOP62 cells, GI50=0.01μM. 19783447
UACC62 Cytotoxicity assay Cytotoxicity against human UACC62 cells, GI50=0.01μM. 19783447
DU145 Cytotoxicity assay Cytotoxicity against human DU145 cells, GI50=0.01μM. 19783447
SF539 Cytotoxicity assay Cytotoxicity against human SF539 cells, GI50=0.01μM. 19783447
SN12C Cytotoxicity assay Cytotoxicity against human SN12C cells, GI50=0.02μM. 19783447
HCT116 Cytotoxicity assay Cytotoxicity against human HCT116 cells, GI50=0.03μM. 19783447
MDA-MB-435 Cytotoxicity assay Cytotoxicity against human MDA-MB-435 cells, GI50=0.04μM. 19783447
OVCAR-3 Cytotoxicity assay Cytotoxicity against human OVCAR-3 cells, GI50=0.22μM. 19783447
HL60 Cytotoxicity assay Cytotoxicity against human HL60 cells by MTT assay, IC50=0.067μM. 19836231
HeLa Cytotoxicity assay Cytotoxicity against human HeLa cells by MTT assay, IC50=0.58μM. 19836231
MDA-MB-231 Cytotoxicity assay Cytotoxicity against human MDA-MB-231 cells by MTT assay, IC50=0.68μM. 19836231
DU145 Cytotoxicity assay Cytotoxicity against human DU145 cells by MTT assay, IC50=1μM. 19836231
HT-29 Cytotoxicity assay Cytotoxicity against human HT-29 cells by MTT assay, IC50=1.07μM. 19836231
HT-29 Cytotoxicity assay Cytotoxicity against human HT-29 cells, ED50=0.06μM. 19839614
HepG2 Cytotoxicity assay Cytotoxicity against human HepG2 cells by MTT assay, IC50=0.06μM. 19863101
BGC823 Cytotoxicity assay Cytotoxicity against human BGC823 cells, IC50=0.21μM. 19916529
A2780 Cytotoxicity assay Cytotoxicity against human A2780 cells, IC50=0.28μM. 19916529
SF539 Antiproliferative assay Antiproliferative activity against human SF539 cells, GI50=0.01μM. 20155916
HOP62 Antiproliferative assay Antiproliferative activity against human HOP62 cells, GI50=0.01μM. 20155916
DU145 Antiproliferative assay Antiproliferative activity against human DU145 cells, GI50=0.01μM. 20155916
UACC62 Antiproliferative assay Antiproliferative activity against human UACC62 cells, GI50=0.01μM. 20155916
SN12C Antiproliferative assay Antiproliferative activity against human SN12C cells, GI50=0.02μM. 20155916
HCT116 Antiproliferative assay Antiproliferative activity against human HCT116 cells, GI50=0.03μM. 20155916
MDA-MB-435 Antiproliferative assay Antiproliferative activity against human MDA-MB-435 cells, GI50=0.04μM. 20155916
OVCAR-3 Antiproliferative assay Antiproliferative activity against human OVCAR-3 cells, GI50=0.22μM. 20155916
K562 Cytotoxicity assay Cytotoxicity against human K562 cells in presence of 10% fetal bovine serum, IC50=0.08μM. 20188578
HeLa Cytotoxicity assay Cytotoxicity against human HeLa cells in presence of 10% fetal bovine serum, IC50=0.63μM. 20188578
HCT15 Cytotoxicity assay Cytotoxicity against human HCT15 cells in presence of 10% fetal bovine serum, IC50=0.64μM. 20188578
DU145 Cytotoxicity assay Cytotoxicity against human DU145 cells in presence of 10% fetal bovine serum, IC50=0.94μM. 20188578
K562 Cytotoxicity assay Cytotoxicity against human imitinib-resistant K562 cells by MTT assay, IC50=0.002μM. 20329739
DA1-3b Cytotoxicity assay Cytotoxicity against mouse dasatinib-resistant DA1-3b cells carrying pCDNA3-p210BCR/ABL plasmid by MTT assay, IC50=0.03μM. 20329739
Raji Cytotoxicity assay Cytotoxicity against human Raji cells by MTT assay, IC50=1μM. 20329739
HL60 Cytotoxicity assay Cytotoxicity against human HL60 cells by MTT assay, IC50=0.59μM. 20356735
HeLa Cytotoxicity assay Cytotoxicity against human HeLa cells by MTT assay, IC50=0.94μM. 20356735
SF539 Cytotoxicity assay Cytotoxicity against human SF539 cells, GI50=0.01μM. 20630766
UACC62 Cytotoxicity assay Cytotoxicity against human UACC62 cells, GI50=0.01μM. 20630766
HOP62 Cytotoxicity assay Cytotoxicity against human HOP62 cells, GI50=0.01μM. 20630766
DU145 Cytotoxicity assay Cytotoxicity against human DU145 cells, GI50=0.01μM. 20630766
MCF7 Cytotoxicity assay Cytotoxicity against human MCF7 cells, GI50=0.01μM. 20630766
SN12C Cytotoxicity assay Cytotoxicity against human SN12C cells, GI50=0.02μM. 20630766
HCT116 Cytotoxicity assay Cytotoxicity against human HCT116 cells, GI50=0.03μM. 20630766
OVCAR-3 Cytotoxicity assay Cytotoxicity against human OVCAR-3 cells, GI50=0.22μM. 20630766
HT-29 Cytotoxicity assay Cytotoxicity against human HT-29 cells, EC50=0.06μM. 20825206
HL60 Cytotoxicity assay Cytotoxicity against human HL60 cells, IC50=0.018μM. 21095131
Col2 Cytotoxicity assay Cytotoxicity against human Col2 cells, IC50=0.045μM. 21095131
A549 Cytotoxicity assay Cytotoxicity against human A549 cells, IC50=0.069μM. 21095131
HT1080 Cytotoxicity assay Cytotoxicity against human HT1080 cells, IC50=0.08μM. 21095131
SNU638 Cytotoxicity assay Cytotoxicity against human SNU638 cells, IC50=0.098μM. 21095131
K562 Cytotoxicity assay Cytotoxicity against human K562 cells by MTT assay, IC50=0.59μM. 21115246
DU145 Cytotoxicity assay Cytotoxicity against human DU145 cells by MTT assay, IC50=0.61μM. 21115246
HCT15 Cytotoxicity assay Cytotoxicity against human HCT15 cells by MTT assay, IC50=0.8μM. 21115246
MCF7 Cytotoxicity assay Cytotoxicity against human MCF7 cells by MTT assay, IC50=2.43μM. 21115246
HL60 Cytotoxicity assay Cytotoxicity against human HL60 cells by MTT assay, IC50=0.018μM. 21353568
Col2 Cytotoxicity assay Cytotoxicity against human Col2 cells by MTT assay, IC50=0.045μM. 21353568
A549 Cytotoxicity assay Cytotoxicity against human A549 cells by MTT assay, IC50=0.069μM. 21353568
HT1080 Cytotoxicity assay Cytotoxicity against human HT1080 cells by MTT assay, IC50=0.08μM. 21353568
SNU638 Cytotoxicity assay Cytotoxicity against human SNU638 cells by MTT assay, IC50=0.098μM. 21353568
MCF7 Cytotoxicity assay Cytotoxicity against human MCF7 cells by SRB assay, IC50=0.0016μM. 21410162
NCI-H460 Anticancer assay Anticancer activity against human NCI-H460 cells, IC50=0.03μM. 21599000
SF268 Anticancer assay Anticancer activity against human SF268 cells, IC50=0.19μM. 21599000
MRC5 Antiproliferative assay Antiproliferative activity against human MRC5 cells, IC50=0.89μM. 21599000
MCF7 Anticancer assay Anticancer activity against human MCF7 cells, IC50=11.12μM. 21599000
HOP62 Antiproliferative assay Antiproliferative activity against human HOP62 cells by SRB assay, GI50=0.01μM. 21710981
SF539 Antiproliferative assay Antiproliferative activity against human SF539 cells by SRB assay, GI50=0.01μM. 21710981
UACC62 Antiproliferative assay Antiproliferative activity against human UACC62 cells by SRB assay, GI50=0.01μM. 21710981
DU145 Antiproliferative assay Antiproliferative activity against human DU145 cells by SRB assay, GI50=0.01μM. 21710981
MCF7 Antiproliferative assay Antiproliferative activity against human MCF7 cells by SRB assay, GI50=0.01μM. 21710981
SN12C Antiproliferative assay Antiproliferative activity against human SN12C cells by SRB assay, GI50=0.02μM. 21710981
HCT116 Antiproliferative assay Antiproliferative activity against human HCT116 cells by SRB assay, GI50=0.03μM. 21710981
OVCAR3 Antiproliferative assay Antiproliferative activity against human OVCAR3 cells by SRB assay, GI50=0.22μM. 21710981
MCF7 Cytotoxicity assay Cytotoxicity against human tamoxifen-resistant MCF7 cells by WST-1 assay, IC50=1.8μM. 22197145
MCF7 Cytotoxicity assay Cytotoxicity against human MCF7 cells by WST-1 assay, IC50=2.6μM. 22197145
MDA-MB-231 Cytotoxicity assay Cytotoxicity against human MDA-MB-231 cells by WST-1 assay, IC50=2.7μM. 22197145
CEM Cytotoxicity assay Cytotoxicity against human CEM cells, IC50=0.005μM. 22305342
MCF7 Cytotoxicity assay Cytotoxicity against human MCF7 cells by SRB assay, IC50=0.0016μM. 22376176
A549 Cytotoxicity assay Cytotoxicity against human A549 cells by SRB assay, IC50=0.0158μM. 23102893
DU145 Cytotoxicity assay Cytotoxicity against human DU145 cells by SRB assay, IC50=0.0287μM. 23102893
KBVIN Cytotoxicity assay Cytotoxicity against human KBVIN cells by SRB assay, IC50=0.0371μM. 23102893
KB Cytotoxicity assay Cytotoxicity against human KB cells by SRB assay, IC50=0.121μM. 23102893
L1210 Cytotoxicity assay Cytotoxicity against mouse L1210 cells, IC50=0.03μM. 23578545
A549 Cytotoxicity assay Cytotoxicity against human A549 cells by WST assay, IC50=0.067μM. 23578545
T24 Cytotoxicity assay Cytotoxicity against human chemo-resistant T24 cells by WST assay, IC50=0.088μM. 23578545
T47D Cytotoxicity assay Cytotoxicity against human T47D cells by MTT assay, IC50=0.07μM. 23608763
SNU638 Cytotoxicity assay Cytotoxicity against human SNU638 cells by MTT assay, IC50=0.28μM. 23608763
CEM Growth inhibition assay Growth inhibition of human CEM cells, GI50=0.002μM. 23750455
CEM/C2 Growth inhibition assay Growth inhibition of multidrug-resistant human CEM/C2 cells, GI50=1μM. 23750455
HT-29 Antiproliferative assay Antiproliferative activity against human HT-29 cells by SRB assay, IC50=0.0007μM. 24200393
MCF7 Antiproliferative assay Antiproliferative activity against human MCF7 cells by SRB assay, IC50=0.0033μM. 24200393
KB Antiproliferative assay Antiproliferative activity against human KB cells by SRB assay, IC50=0.02μM. 24200393
HeLa Antiproliferative assay Antiproliferative activity against human HeLa cells by SRB assay, IC50=0.13μM. 24200393
DU145 Cytotoxicity assay Cytotoxicity against human DU145 cells by SRB assay, GI50=0.01μM. 24502276
UACC62 Cytotoxicity assay Cytotoxicity against human UACC62 cells by SRB assay, GI50=0.01μM. 24502276
SF539 Cytotoxicity assay Cytotoxicity against human SF539 cells by SRB assay, GI50=0.01μM. 24502276
HOP62 Cytotoxicity assay Cytotoxicity against human HOP62 cells by SRB assay, GI50=0.01μM. 24502276
MCF7 Cytotoxicity assay Cytotoxicity against human MCF7 cells by SRB assay, GI50=0.013μM. 24502276
SN12C Cytotoxicity assay Cytotoxicity against human SN12C cells by SRB assay, GI50=0.02μM. 24502276
HCT116 Cytotoxicity assay Cytotoxicity against human HCT116 cells by SRB assay, GI50=0.03μM. 24502276
OVCAR3 Cytotoxicity assay Cytotoxicity against human OVCAR3 cells by SRB assay, GI50=0.22μM. 24502276
MDA-MB-231 Apoptosis assay Induction of apoptosis in human MDA-MB-231 cells assessed as p53 phosphorylation at Ser15 by Western blotting analysis 24980118
A375 Apoptosis assay Induction of apoptosis in human A375 cells assessed as p53 phosphorylation at Ser15 by Western blotting analysis 24980118
A549 Cytotoxicity assay Cytotoxicity against human A549 cells by MTT assay, IC50=0.001μM. 25237727
BGC823 Cytotoxicity assay Cytotoxicity against human BGC823 cells by MTT assay, IC50=0.04μM. 25237727
A2780 Cytotoxicity assay Cytotoxicity against human A2780 cells by MTT assay, IC50=0.9μM. 25237727
HCT8 Cytotoxicity assay Cytotoxicity against human HCT8 cells by MTT assay, IC50=3.6μM. 25237727
Bel7402 Cytotoxicity assay Cytotoxicity against human Bel7402 cells by MTT assay, IC50=6.3μM. 25237727
DU145 Cytotoxicity assay Cytotoxicity against human DU145 cells measured on day 4 by CCK8 assay, IC50=0.02μM. 25936262
HeLa Cytotoxicity assay Cytotoxicity against human HeLa cells measured on day 4 by CCK8 assay, IC50=0.18μM. 25936262
T47D Cytotoxicity assay Cytotoxicity against human T47D cells measured on day 4 by CCK8 assay, IC50=1.84μM. 25936262
HCT15 Cytotoxicity assay Cytotoxicity against human HCT15 cells measured on day 4 by CCK8 assay, IC50=2.82μM. 25936262
WI38 Cytotoxicity assay Cytotoxicity against human WI38 cells by MTT assay, IC50=0.23μM. 26063305
MCF7 Antiproliferative assay Antiproliferative activity against human MCF7 cells by SRB assay, IC50=0.03μM. 28274626
HeLa Cytotoxicity assay Cytotoxicity against human HeLa cells assessed as reduction in cell viability by MTT assay, IC50=0.12μM. 28425292
A549 Cytotoxicity assay Cytotoxicity against human A549 cells by MTT assay, IC50=0.7μM. 28506750
NCI-H1299 Cytotoxicity assay Cytotoxicity against human NCI-H1299 cells by MTT assay, IC50=0.8μM. 28506750
NCI-H1975 Cytotoxicity assay Cytotoxicity against human NCI-H1975 cells by MTT assay, IC50=1.2μM. 28506750
HOP62 Antiproliferative assay Antiproliferative activity against human HOP62 cells assessed as growth inhibition, GI50=0.01μM. 28657311
SF539 Antiproliferative assay Antiproliferative activity against human SF539 cells assessed as growth inhibition, GI50=0.01μM. 28657311
UACC62 Antiproliferative assay Antiproliferative activity against human UACC62 cells assessed as growth inhibition, GI50=0.01μM. 28657311
DU145 Antiproliferative assay Antiproliferative activity against human DU145 cells assessed as growth inhibition, GI50=0.01μM. 28657311
MCF7 Antiproliferative assay Antiproliferative activity against human MCF7 cells assessed as growth inhibition, GI50=0.013μM. 28657311
SN12C Antiproliferative assay Antiproliferative activity against human SN12C cells assessed as growth inhibition, GI50=0.02μM. 28657311
HCT116 Antiproliferative assay Antiproliferative activity against human HCT116 cells assessed as growth inhibition, GI50=0.03μM. 28657311
OVCAR3 Antiproliferative assay Antiproliferative activity against human OVCAR3 cells assessed as growth inhibition, GI50=0.22μM. 28657311
PC3 Antiproliferative assay Antiproliferative activity against human PC3 cells by MTT assay, IC50=6.96μM. 29131616
HL60 Antiproliferative assay Antiproliferative activity against human HL60 cells, IC50=0.0067μM. 29429833
TC32 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for TC32 cells 29435139
DAOY qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for DAOY cells 29435139
SJ-GBM2 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SJ-GBM2 cells 29435139
A673 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for A673 cells 29435139
SK-N-MC qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-MC cells 29435139
BT-37 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-37 cells 29435139
NB-EBc1 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB-EBc1 cells 29435139
U-2 OS qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for U-2 OS cells 29435139
Saos-2 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Saos-2 cells 29435139
SK-N-SH qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-SH cells 29435139
NB1643 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB1643 cells 29435139
LAN-5 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for LAN-5 cells 29435139
BT-12 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-12 cells 29435139
Rh18 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh18 cells 29435139
OHS-50 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for OHS-50 cells 29435139
RD qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for RD cells 29435139
MG 63 (6-TG R) qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for MG 63 (6-TG R) cells 29435139
Rh41 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh41 cells 29435139
NB1643 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for NB1643 cells 29435139
A673 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for A673 cells) 29435139
SK-N-MC qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for SK-N-MC cells 29435139
BT-12 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for BT-12 cells 29435139
LAN-5 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for LAN-5 cells 29435139
DAOY qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for DAOY cells 29435139
NB-EBc1 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for NB-EBc1 cells 29435139
SJ-GBM2 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for SJ-GBM2 cells 29435139
BT-37 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for BT-37 cells 29435139
TC32 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for TC32 cells 29435139
MG 63 (6-TG R) qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for MG 63 (6-TG R) cells 29435139
U-2 OS qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for U-2 OS cells 29435139
Rh41 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for Rh41 cells 29435139
RD qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for RD cells 29435139
Rh18 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for Rh18 cells 29435139
Rh30 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for Rh30 cells 29435139
Saos-2 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for Saos-2 cells 29435139
OHS-50 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for OHS-50 cells 29435139
SK-N-SH qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for SK-N-SH cells 29435139
HepG2 Antiproliferative assay Antiproliferative activity against human HepG2 cells by MTT assay, IC50=0.5μM. 30007563
HeLa Antiproliferative assay Antiproliferative activity against human HeLa cells by MTT assay, IC50=1.3μM. 30007563
CCRF-CEM Cytotoxicity assay Cytotoxicity against human CCRF-CEM cells by MTT assay, IC50=0.002μM. 30543429
HuH7 Cytotoxicity assay Cytotoxicity against human HuH7 cells by MTT assay, IC50=0.0023μM. 30543429
HCT116 Cytotoxicity assay Cytotoxicity against human HCT116 cells by MTT assay, IC50=0.013μM. 30543429
DU145 Cytotoxicity assay Cytotoxicity against human DU145 cells by MTT assay, IC50=0.016μM. 30543429
A549 Cytotoxicity assay Cytotoxicity against human A549 cells by MTT assay, IC50=0.04μM. 30543429
HuH7 Apoptosis assay Induction of apoptosis in human HuH7 cells assessed as increase in cytochrome C levels by Hoechst staining-based assay 30716712
Mahlavu Apoptosis assay Induction of apoptosis in human Mahlavu cells assessed as increase in cytochrome C levels by Hoechst staining-based assay 30716712
HL60 Function assay Tested in vitro for growth inhibitory activity against HL60 (human promyelocytic leukemic) cells, IC50=0.005μM. ChEMBL
DC-3F Function assay Tested in vitro for growth inhibitory activity against DC-3F (hamster lung) cells, IC50=0.006μM. ChEMBL
833K Function assay Tested in vitro for growth inhibitory activity against 833K (human teratorcarcinoma) cells, IC50=0.01μM. ChEMBL
HuH7 Cytotoxicity assay Cytotoxicity against human HuH7 cells assessed as inhibition of cell proliferation by sulforhodamine B assay, IC50=0.1μM. ChEMBL
leukemia cells Function assay Compound was evaluated for cytotoxic activity on L1210 murine leukemia cells, IC50=0.126μM. ChEMBL
MV Cytotoxicity assay Cytotoxicity against human MV cells assessed as inhibition of cell proliferation by sulforhodamine B assay, IC50<1μM. ChEMBL
SW480 Function assay Inhibition of DNA topoisomerase 1 in Homo sapiens (human) SW480 cells, IC50=3.75μM. ChEMBL
HCT116 Function assay Inhibition of DNA topoisomerase 1 in Homo sapiens (human) HCT116 cells, IC50=4.75μM. ChEMBL
VACO 241 Function assay Inhibition of DNA topoisomerase 1 in Homo sapiens (human) VACO 241 cells, IC50=4.95μM. ChEMBL
他の多くの細胞株試験データをご覧になる場合はこちらをクリックして下さい

生物活性

製品説明 Camptothecin (CPT) is a specific inhibitor of DNA topoisomerase I (Topo I) with IC50 of 0.68 μM in a cell-free assay. Camptothecin induces apoptosis in cancer cells via microRNA-125b-mediated mitochondrial pathways. Phase 2.
Targets
Topo I [2]
(Cell-free assay)
0.68 μM
In Vitro
In vitro Camptothecin, a plant alkaloid orignially isolated from Camptotheca acuminate in 1966. [1] Camptothecin is noted to halt cells during the S phase of mitosis. Camptothecin displays nanomolar potency in cytotoxicity against many human tumor cell lines, including HT29, LOX, SKOV3, and SKVLB, with IC50 values ranging from 37 nM to 48 nM. [2] In combination with TNF, Camptothecin induces apoptosis in primary mouse hepatocytes, with an IC50 value of 13 μM. Camptothecin also abrogated the TNF-induced NF-κB Activation, as well as the expression of TNF-receptor associated factor 2 (TRAF2), X-linked inhibitor of apoptosis protein (X-IAP), and FLICE-inhibitory protein (FLIP). [4] In HCT116 cells, Camptothecin (5 μM) induces proteasome-mediated degradation of mixed lineage leukemia 5 (MLL5) protein, which leads to phosphorylation of p53 at Ser392. [5] Due to the low solubility and adverse effects of Camptothecin, various Camptothecin analogues have been developed, and two of them, topotecan and irinotecan, has been approved by FDA and are used in cancer chemotherapy.
Kinase Assay Topoisomerase I Cleavable Complex Assay
Topoisomerase I is isolated from calf thymus and is devoid of topoisomerase II. All reactions are carried out in 10 mL volumes of reaction buffer (50 mM Tris-HCl, pH 7.5, 100 mM KCl, 0.5 mM EDTA, and 30 pg/mL BSA) in microtiter plates. Camptothecin is dissolved in DMSO at 10 mg/mL and serially diluted in 96-well microtiter plates to which the 32P end-labeled pBR322 DNA and topoisomerase enzyme are added. The reaction mixture is incubated at room temperature for 30 min and then the reaction stopped by adding 2 mL of a mixture of sodium dodecyl sulfate and proteinase K (1.6% and 0.14 mg/mL final concentrations, respectively). The plates are heated at 50 °C for 30 min, 10 mL of standard stop mixture containing 0.45 N NaOH is added in order to generate single-stranded DNA, and the samples are electrophoresed in 1.5% agarose gels in TBE buffer. Gels are blotted on nitrocellulose paper, dried, and exposed to X-ray film. The units of cleavage are calculated from the autoradiographs and plotted against the log drug concentration. The IC50 values are then obtaine
細胞実験 細胞株 U87MG, A549 and H838 cells
濃度 0.17 nM–10 mM
反応時間 48 hours
実験の流れ Tumor cells are plated in 100 μL of medium in 96-well microtiter plates at a density of 1500 to 4000 cells per well and allowed to adhere overnight. Cells are incubated with Camptothecin for 48 hours and then with fresh medium for 48 hours. Camptothecin at each concentration is added in quadruplicate. Following a 4-hour incubation of treated cells with MTT, the reduced dye product is extracted from the cells with 0.2 mL of DMSO followed by 50 μL of Sorensen's buffer. The plates are shaken briefly, and the absorbance at 570 nm is read and quantitated. Curves are fitted to the MTT assay data using a four-parameter logistic equation.
実験結果図 Methods Biomarkers 結果図 PMID
Western blot Cyclin1 / CDK1 / CDK2 Vimentin / Fibronectin / E-cadherin TGF-β / PI3K / pPI3K / AKT / pAKT p53 / Cleaved caspase-3 / Cleaved PARP 29963130
In Vivo
In Vivo Camptothecin (8 mg/kg) displays complete growth inhibition and regression in mice xenografts of various tumors, including colon, lung, breast, stomach, and ovary tumors. [3] In mice, combinations of Camptothecin (50 mg/kg) and TNF (5 and 7 μg/kg), but not Camptothecin alone, induces liver damage. [4]
動物実験 動物モデル Nude mice (NIH-I high fertility strain) bearing xenografts of CASE, SW48, DOY, SPA, and CLO cells
投与量 0–8 mg/kg
投与経路 Administered via i.m. or i.v. injection

化学情報

分子量 348.35 化学式

C20H16N2O4
CAS No. 7689-03-4 SDF Download Camptothecin (CPT) SDFをダウンロードする
Smiles CCC1(C2=C(COC1=O)C(=O)N3CC4=CC5=CC=CC=C5N=C4C3=C2)O
保管

In vitro
Batch:

0.1M NaOH : 2.5 mg/mL

DMSO : Insoluble ( 吸湿したDMSOは溶解度を減少させます。新しいDMSOをご使用ください。)

Water : Insoluble

モル濃度計算器

in vivo
Batch:

Add solvents to the product individually and in order.

投与溶液組成計算機

実験計算

モル濃度計算器

質量 濃度 体積 分子量

投与溶液組成計算機(クリア溶液)

ステップ１：実験データを入力してください。（実験操作によるロスを考慮し、動物数を1匹分多くして計算・調製することを推奨します）

mg/kg g μL 匹

ステップ２：投与溶媒の組成を入力してください。（ロット毎に適した溶解組成が異なる場合があります。詳細については弊社までお問い合わせください）

% DMSO % % Tween 80 % ddH2O
%DMSO %

計算結果：

投与溶媒濃度： mg/ml;

DMSOストック溶液調製方法： mg 試薬を μL DMSOに溶解する（濃度 mg/mL, 注：濃度が当該ロットのDMSO溶解度を超える場合はご連絡ください。 )

投与溶媒調製方法：Take μL DMSOストック溶液に μL PEG300，を加え、完全溶解後μL Tween 80，を加えて完全溶解させた後 μL ddH2O，を加え完全に溶解させます。

投与溶媒調製方法：μL DMSOストック溶液に μL Corn oil，を加え、完全溶解。

注意：１.ストック溶液に沈殿、混濁などがないことをご確認ください；
２.順番通りに溶剤を加えてください。次のステップに進む前に溶液に沈殿、混濁などがないことを確認してから加えてください。ボルテックス、ソニケーション、水浴加熱など物理的な方法で溶解を早めることは可能です。

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Tags: Camptothecin (CPT)を買う | Camptothecin (CPT) ic50 | Camptothecin (CPT)供給者 | Camptothecin (CPT)を購入する | Camptothecin (CPT)費用 | Camptothecin (CPT)生産者 | オーダーCamptothecin (CPT) | Camptothecin (CPT)化学構造 | Camptothecin (CPT)分子量 | Camptothecin (CPT)代理店