PFKFB

亜型選択性的な製品

PFKFB3 PFKFB4

PFKFB製品

All (4)
PFKFB阻害剤 (4)
新製品

製品コード	製品名称	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S7289	PFK15	PFK15 (PFK-015) is a potent and selective 6-phosphofructo-2-kinase (PFKFB3) inhibitor with IC50 of 207 nM.	Clin Exp Med, 2024, 24(1):219 Eur J Med Res, 2024, 29(1):236 Nat Commun, 2023, 14(1):5552
S7639	3PO	3PO (3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one) is a small-molecule inhibitor of PFKFB3 with an IC50 of 22.9 μM for recombinant human PFKFB3 protein and does not inhibit PFK-1 activity. It suppresses glucose uptake, and decreases the intracellular concentration of Fru-2,6-BP, lactate, ATP, NAD+, and NADH.	J Transl Med, 2024, 22(1):954 Respir Res, 2022, 23(1):75 Am J Transl Res, 2022, 14(10):7552-7565
S8807	PFK158	PFK158 is a potent and selective inhibitor of PFKFB3. It has improved PK properties and causes ~80% growth inhibition in several mouse models of human-derived tumors.	Nat Metab, 2022, 4(10):1287-1305 Cancers (Basel), 2022, 14(9)2113 Front Oncol, 2022, 12:826655
S0400	KAN0438757	KAN0438757 is a potent and selective inhibitor of the metabolic kinase PFKFB3 (6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3) with IC50 of 0.19 μM and 3.6 μM for PFKFB3 and PFKFB4, respectively.	Mol Cell Proteomics, 2023, 22(11):100649 Mol Cell Proteomics, 2023, 10.1016/j.mcpro.2023.100649
S7289	PFK15	PFK15 (PFK-015) is a potent and selective 6-phosphofructo-2-kinase (PFKFB3) inhibitor with IC50 of 207 nM.	Clin Exp Med, 2024, 24(1):219 Eur J Med Res, 2024, 29(1):236 Nat Commun, 2023, 14(1):5552
S7639	3PO	3PO (3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one) is a small-molecule inhibitor of PFKFB3 with an IC50 of 22.9 μM for recombinant human PFKFB3 protein and does not inhibit PFK-1 activity. It suppresses glucose uptake, and decreases the intracellular concentration of Fru-2,6-BP, lactate, ATP, NAD+, and NADH.	J Transl Med, 2024, 22(1):954 Respir Res, 2022, 23(1):75 Am J Transl Res, 2022, 14(10):7552-7565
S8807	PFK158	PFK158 is a potent and selective inhibitor of PFKFB3. It has improved PK properties and causes ~80% growth inhibition in several mouse models of human-derived tumors.	Nat Metab, 2022, 4(10):1287-1305 Cancers (Basel), 2022, 14(9)2113 Front Oncol, 2022, 12:826655
S0400	KAN0438757	KAN0438757 is a potent and selective inhibitor of the metabolic kinase PFKFB3 (6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3) with IC50 of 0.19 μM and 3.6 μM for PFKFB3 and PFKFB4, respectively.	Mol Cell Proteomics, 2023, 22(11):100649 Mol Cell Proteomics, 2023, 10.1016/j.mcpro.2023.100649

PFKFB阻害剤の選択性比較

Tags: PFKFB inhibitor|PFKFB agonist|PFKFB activator|PFKFB inducer|PFKFB antagonist|PFKFB signaling pathway|PFKFB assay kit