NLRP3

NLRP3製品

• All (19)
• NLRP3阻害剤 (15)
• NLRP3活性剤(1)
• NLRP3作動薬(1)
• 新製品

製品コード	製品名称	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S7809	MCC950 Sodium	MCC950 Sodium is a potent, selective inhibitor of NLRP3 with IC50 of 7.5 nM in BMDMs; but not the AIM2, NLRC4 or NLRP1 inflammasomes.	Circ Res, 2024, 135(9):933-950 Bone Res, 2024, 12(1):53 Int J Biol Sci, 2024, 20(9):3393-3411
S8930	MCC950	MCC950 (CP-456773, CRID3) is a potent and selective inhibitor of NLRP3 (NOD-like receptor (NLR) family, pyrin domain-containing protein 3) with IC50 of 7.5 nM and 8.1 nM in BMDMs and HMDMs, respectively.	Int J Biol Sci, 2024, 20(14):5695-5714 Cell Death Dis, 2024, 15(1):43 Cell Prolif, 2024, e13720.
S6653	Nigericin sodium salt	Nigericin sodium salt is an antibiotic derived from Streptomyces hygroscopicus that works by acting as an H+, K+, and Pb2+ ionophore.Nigericin can activate NLRP3 inflammasome to induce pro-inflammatory and immunostimulatory processes.	Biomed Pharmacother, 2024, 174:116548 Biomed Pharmacother, 2024, 180:117512 J Anim Sci Biotechnol, 2024, 15(1):116
S5774	CY-09	CY-09 is a specific NLRP3 inflammasome inhibitor that directly targeted NLRP3 itself. It is tested against the five major cytochrome P450 enzymes 1A2, 2C9, 2C19, 2D6, and 3A4 with half maximal inhibitory concentration (IC50) values of 18.9, 8.18, >50, >50, and 26.0 µM, respectively.	iScience, 2024, 27(3):109118 Antioxidants (Basel), 2023, 12(3)722 J Exp Clin Cancer Res, 2022, 41(1):74
S8559	INF39	INF39 is a nontoxic, irreversible NLRP3 inhibitor that counteracts NLRP3 activation through direct irreversible interaction with NLRP3 and partial inhibition of LPS-driven pro-inflammatory gene expression.	Chin Med J (Engl), 2022, 135(12):1474-1485 Biomed Res Int, 2022, 2022:7250578 Int Immunopharmacol, 2021, 92:107358
S3680	NLRP3 Inflammasome Inhibitor I	NLRP3 Inflammasome Inhibitor I, an intermediate substrate in the synthesis of glyburide which is free of the cyclohexylurea moiety involved in insulin release, is a novel inhibitor of the NLRP3 inflammasome.	eprints, 2023, 10.14943/doctoral.k15475 Am J Pathol, 2022, S0002-9440(22)00076-1 Immunopharmacol Immunotoxicol, 2022, 1-24
S8907	Dapansutrile	Dapansutrile is a novel and selective NLRP3 inflammasome inhibitor.	iScience, 2023, 26(3):106089 iScience, 2023, 26(3):106089
S3871	Muscone	Muscone (3-Methylcyclopentadecanone, Methylexaltone), a flavouring ingredient, is an organic compound that is the primary contributor to the odor of musk and also a potent anti-inflammatory agent. Muscone significantly downregulats the levels of LPS-induced inflammatory cytokines and inhibits NF-κB and NLRP3 inflammasome activation in BMDMs. Muscone remarkably decreases the levels of inflammatory cytokines (IL-1β, TNF-α and IL-6).	J Pharm Pharmacol, 2019, 71(11):1706-1713
S3939	4'-Methoxyresveratrol	4-Methoxyresveratrol is a stibenoid found in the Chinese herb Gnetum cleistostachyum. 4'-Methoxyresveratrol alleviates AGE-induced inflammation through suppressing RAGE-mediated MAPK/NF-κB signaling pathway and NLRP3 inflammasome activation.
E0138	YQ128	YQ128 is a selective inhibitor of NLRP3 with an IC50 of 0.30 µM.
S3290	Procyanidin B2 (PCB2)	Procyanidin B2 (PCB2), a natural flavonoid found in commonly consumed foods, possess anti-inflammatory, anti-oxidant and anti-cancer activities. Procyanidin B2 activates PPARγ to induce M2 polarization in mouse macrophages. Procyanidin B2 significantly suppresses the activation of NLRP3 inflammasome in the lung tissue induced by paraquat in the rat model.	BMC Cardiovasc Disord, 2024, 24(1):231 Front Pharmacol, 2021, 12:639651
S9899	BMS-986299	BMS-986299 is a novel NLRP3 agonist that induces IL8 release to activate natural killer (NK) cells.
E1970New	BAL-0028	BAL-0028 (Compound 3), which belongs to the indazole class is an inhibitor of NLRP3 activation with an IC50 value of 25 nM. BAL-0028 binds tightly to the NACHT domain of NLRP3, with KD values ranging from 104 to 123 nM. BAL-0028 also exhibits anti-inflammatory activity.
E4663New	INF195	INF 195 is an NLRP3 inhibitor which inhibits NLRP3-driven macrophage pyrodeath and IL-1β release. At low dose, INF 195 can reduce the infarct size of isolated mouse hearts and effectively prevent myocardial ischemia/reperfusion injury.
E1281	Dimethyl itaconate	Dimethyl itaconate can reprogram neurotoxic to neuroprotective primary astrocytes through the regulation of LPS-induced Nod-like receptor protein 3 (NLRP3) inflammasome and nuclear factor 2/heme oxygenase-1 (NRF2/HO-1) pathways.
E1872New	Selnoflast	Selnoflast(RO-7486967) is a selective and reversible small molecule inhibitor of NLRP3 inflammasome, with the potential to treat moderate to severe active ulcerative colitis.
S9261	Shionone	Shionone is a triterpenoid component derived from the herbal medicine Aster tataricus, anit has anti-inflammatory properties. Shionone specifically inhibits NLRP3 inflammasome activation in vitro and in vivo.	J Cardiothorac Surg, 2024, 19(1):435
E0225	Licochalcone B	Licochalcone B (Lico B), extracted from Glycyrrhiza uralensis Fisch, induces the cell cycle arrest and apoptosis in human hepatoma cell HepG2. Licochalcone B specifically inhibits the NLRP3 inflammasome by disrupting NEK7‐NLRP3 interaction.
S9899	BMS-986299	BMS-986299 is a novel NLRP3 agonist that induces IL8 release to activate natural killer (NK) cells.
S7809	MCC950 Sodium	MCC950 Sodium is a potent, selective inhibitor of NLRP3 with IC50 of 7.5 nM in BMDMs; but not the AIM2, NLRC4 or NLRP1 inflammasomes.	Circ Res, 2024, 135(9):933-950 Bone Res, 2024, 12(1):53 Int J Biol Sci, 2024, 20(9):3393-3411
S8930	MCC950	MCC950 (CP-456773, CRID3) is a potent and selective inhibitor of NLRP3 (NOD-like receptor (NLR) family, pyrin domain-containing protein 3) with IC50 of 7.5 nM and 8.1 nM in BMDMs and HMDMs, respectively.	Int J Biol Sci, 2024, 20(14):5695-5714 Cell Death Dis, 2024, 15(1):43 Cell Prolif, 2024, e13720.
S5774	CY-09	CY-09 is a specific NLRP3 inflammasome inhibitor that directly targeted NLRP3 itself. It is tested against the five major cytochrome P450 enzymes 1A2, 2C9, 2C19, 2D6, and 3A4 with half maximal inhibitory concentration (IC50) values of 18.9, 8.18, >50, >50, and 26.0 µM, respectively.	iScience, 2024, 27(3):109118 Antioxidants (Basel), 2023, 12(3)722 J Exp Clin Cancer Res, 2022, 41(1):74
S8559	INF39	INF39 is a nontoxic, irreversible NLRP3 inhibitor that counteracts NLRP3 activation through direct irreversible interaction with NLRP3 and partial inhibition of LPS-driven pro-inflammatory gene expression.	Chin Med J (Engl), 2022, 135(12):1474-1485 Biomed Res Int, 2022, 2022:7250578 Int Immunopharmacol, 2021, 92:107358
S3680	NLRP3 Inflammasome Inhibitor I	NLRP3 Inflammasome Inhibitor I, an intermediate substrate in the synthesis of glyburide which is free of the cyclohexylurea moiety involved in insulin release, is a novel inhibitor of the NLRP3 inflammasome.	eprints, 2023, 10.14943/doctoral.k15475 Am J Pathol, 2022, S0002-9440(22)00076-1 Immunopharmacol Immunotoxicol, 2022, 1-24
S8907	Dapansutrile	Dapansutrile is a novel and selective NLRP3 inflammasome inhibitor.	iScience, 2023, 26(3):106089 iScience, 2023, 26(3):106089
S3871	Muscone	Muscone (3-Methylcyclopentadecanone, Methylexaltone), a flavouring ingredient, is an organic compound that is the primary contributor to the odor of musk and also a potent anti-inflammatory agent. Muscone significantly downregulats the levels of LPS-induced inflammatory cytokines and inhibits NF-κB and NLRP3 inflammasome activation in BMDMs. Muscone remarkably decreases the levels of inflammatory cytokines (IL-1β, TNF-α and IL-6).	J Pharm Pharmacol, 2019, 71(11):1706-1713
S3939	4'-Methoxyresveratrol	4-Methoxyresveratrol is a stibenoid found in the Chinese herb Gnetum cleistostachyum. 4'-Methoxyresveratrol alleviates AGE-induced inflammation through suppressing RAGE-mediated MAPK/NF-κB signaling pathway and NLRP3 inflammasome activation.
E0138	YQ128	YQ128 is a selective inhibitor of NLRP3 with an IC50 of 0.30 µM.
S3290	Procyanidin B2 (PCB2)	Procyanidin B2 (PCB2), a natural flavonoid found in commonly consumed foods, possess anti-inflammatory, anti-oxidant and anti-cancer activities. Procyanidin B2 activates PPARγ to induce M2 polarization in mouse macrophages. Procyanidin B2 significantly suppresses the activation of NLRP3 inflammasome in the lung tissue induced by paraquat in the rat model.	BMC Cardiovasc Disord, 2024, 24(1):231 Front Pharmacol, 2021, 12:639651
E1970New	BAL-0028	BAL-0028 (Compound 3), which belongs to the indazole class is an inhibitor of NLRP3 activation with an IC50 value of 25 nM. BAL-0028 binds tightly to the NACHT domain of NLRP3, with KD values ranging from 104 to 123 nM. BAL-0028 also exhibits anti-inflammatory activity.
E4663New	INF195	INF 195 is an NLRP3 inhibitor which inhibits NLRP3-driven macrophage pyrodeath and IL-1β release. At low dose, INF 195 can reduce the infarct size of isolated mouse hearts and effectively prevent myocardial ischemia/reperfusion injury.
E1872New	Selnoflast	Selnoflast(RO-7486967) is a selective and reversible small molecule inhibitor of NLRP3 inflammasome, with the potential to treat moderate to severe active ulcerative colitis.
S9261	Shionone	Shionone is a triterpenoid component derived from the herbal medicine Aster tataricus, anit has anti-inflammatory properties. Shionone specifically inhibits NLRP3 inflammasome activation in vitro and in vivo.	J Cardiothorac Surg, 2024, 19(1):435
E0225	Licochalcone B	Licochalcone B (Lico B), extracted from Glycyrrhiza uralensis Fisch, induces the cell cycle arrest and apoptosis in human hepatoma cell HepG2. Licochalcone B specifically inhibits the NLRP3 inflammasome by disrupting NEK7‐NLRP3 interaction.
S6653	Nigericin sodium salt	Nigericin sodium salt is an antibiotic derived from Streptomyces hygroscopicus that works by acting as an H+, K+, and Pb2+ ionophore.Nigericin can activate NLRP3 inflammasome to induce pro-inflammatory and immunostimulatory processes.	Biomed Pharmacother, 2024, 174:116548 Biomed Pharmacother, 2024, 180:117512 J Anim Sci Biotechnol, 2024, 15(1):116
S9899	BMS-986299	BMS-986299 is a novel NLRP3 agonist that induces IL8 release to activate natural killer (NK) cells.
E1970New	BAL-0028	BAL-0028 (Compound 3), which belongs to the indazole class is an inhibitor of NLRP3 activation with an IC50 value of 25 nM. BAL-0028 binds tightly to the NACHT domain of NLRP3, with KD values ranging from 104 to 123 nM. BAL-0028 also exhibits anti-inflammatory activity.
E4663New	INF195	INF 195 is an NLRP3 inhibitor which inhibits NLRP3-driven macrophage pyrodeath and IL-1β release. At low dose, INF 195 can reduce the infarct size of isolated mouse hearts and effectively prevent myocardial ischemia/reperfusion injury.
E1872New	Selnoflast	Selnoflast(RO-7486967) is a selective and reversible small molecule inhibitor of NLRP3 inflammasome, with the potential to treat moderate to severe active ulcerative colitis.