NAMPT

NAMPT製品

All (8)
NAMPT阻害剤 (6)
NAMPT活性剤(2)
新製品

製品コード	製品名称	製品説明	文献中Selleckの製品使用例
S2799	Daporinad (FK866)	Daporinad (FK866) effectively inhibits nicotinamide phosphoribosyltransferase (NMPRTase; Nampt) with IC50 of 0.09 nM in a cell-free assay. Daporinad (FK866, APO866) triggers autophagy. Phase 1/2.	Cell Discov, 2024, 10(1):39 Theranostics, 2024, 14(7):2794-2815 Theranostics, 2024, 14(15):5999-6015
S8117	GMX1778	GMX1778 is a potent and specific inhibitor of nicotinamide phosphoribosyltransferase (NAMPT) with IC50 and K_d of < 25 nM and 120 nM, respectively. GMX1778 induces programmed cell death with apoptotic features. Phase 1.	Nat Cell Biol, 2023, 10.1038/s41556-023-01280-z Cancers (Basel), 2023, 15(5)1415 Cancer Res Commun, 2023, 10.1158/2767-9764.CRC-22-0521
S8444	KPT 9274 (ATG-019)	KPT 9274 ( ATG-019) is an orally bioavailable small molecule that is a non-competitive dual inhibitor of PAK4 and NAMPT. It shows an IC50 of ~120 nM for NAMPT in a cell-free enzymatic assay.	Cell Rep Med, 2024, 5(2):101416 Sci Rep, 2023, 13(1):3334 Sci Adv, 2023, 9(15):eadf8522
S7316	STF-118804	STF-118804 is a highly specific NAMPT inhibitor.	Cell Metab, 2022, S1550-4131(22)00453-3 Cell Rep, 2021, 36(6):109516 Cell Metab, 2020, 31(3):564-579
S7968	P7C3	P7C3 is a potent proneurogenic and neuroprotective chemical that targets NAMPT enzyme.	Front Oncol, 2023, 13:1225220 Front Bioeng Biotechnol, 2022, 10:855755 Front Cell Dev Biol, 2022, 10:1032360
S8980	SBI-797812	SBI-797812 is a NAMPT activator which is structurally similar to active-site directed NAMPT inhibitors and blocks binding of these inhibitors to NAMPT. SBI-797812 turns NAMPT into a "super catalyst" that more efficiently generates NMN.	Biotechnol Prog, 2023, e3365.
S9706	OT-82	OT-82 is a novel nicotinamide phosphoribosyltransferase (NAMPT) inhibitor with average IC50s of 13.03 nM in non-HP cancer cells and 2.89 nM in HP cancer cells, respectively.	Sci Rep, 2023, 13(1):3334
S6629	GNE-617	GNE-617 is a highly potent inhibitor of NAMPT activity with an IC50 of 5 nM.
S2799	Daporinad (FK866)	Daporinad (FK866) effectively inhibits nicotinamide phosphoribosyltransferase (NMPRTase; Nampt) with IC50 of 0.09 nM in a cell-free assay. Daporinad (FK866, APO866) triggers autophagy. Phase 1/2.	Cell Discov, 2024, 10(1):39 Theranostics, 2024, 14(7):2794-2815 Theranostics, 2024, 14(15):5999-6015
S8117	GMX1778	GMX1778 is a potent and specific inhibitor of nicotinamide phosphoribosyltransferase (NAMPT) with IC50 and K_d of < 25 nM and 120 nM, respectively. GMX1778 induces programmed cell death with apoptotic features. Phase 1.	Nat Cell Biol, 2023, 10.1038/s41556-023-01280-z Cancers (Basel), 2023, 15(5)1415 Cancer Res Commun, 2023, 10.1158/2767-9764.CRC-22-0521
S8444	KPT 9274 (ATG-019)	KPT 9274 ( ATG-019) is an orally bioavailable small molecule that is a non-competitive dual inhibitor of PAK4 and NAMPT. It shows an IC50 of ~120 nM for NAMPT in a cell-free enzymatic assay.	Cell Rep Med, 2024, 5(2):101416 Sci Rep, 2023, 13(1):3334 Sci Adv, 2023, 9(15):eadf8522
S7316	STF-118804	STF-118804 is a highly specific NAMPT inhibitor.	Cell Metab, 2022, S1550-4131(22)00453-3 Cell Rep, 2021, 36(6):109516 Cell Metab, 2020, 31(3):564-579
S9706	OT-82	OT-82 is a novel nicotinamide phosphoribosyltransferase (NAMPT) inhibitor with average IC50s of 13.03 nM in non-HP cancer cells and 2.89 nM in HP cancer cells, respectively.	Sci Rep, 2023, 13(1):3334
S6629	GNE-617	GNE-617 is a highly potent inhibitor of NAMPT activity with an IC50 of 5 nM.
S7968	P7C3	P7C3 is a potent proneurogenic and neuroprotective chemical that targets NAMPT enzyme.	Front Oncol, 2023, 13:1225220 Front Bioeng Biotechnol, 2022, 10:855755 Front Cell Dev Biol, 2022, 10:1032360
S8980	SBI-797812	SBI-797812 is a NAMPT activator which is structurally similar to active-site directed NAMPT inhibitors and blocks binding of these inhibitors to NAMPT. SBI-797812 turns NAMPT into a "super catalyst" that more efficiently generates NMN.	Biotechnol Prog, 2023, e3365.

NAMPT阻害剤の選択性比較