LDH

亜型選択性的な製品

LDHA LDHB

LDH製品

All (8)
LDH阻害剤 (6)
LDH活性剤(1)
LDHモジュレータ(1)
新製品

製品コード	製品名称	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S6871	Sodium oxamate	Sodium oxamate (SO, Aminooxoacetic acid, Oxamic acid) is an inhibitor of lactate dehydrogenase (LDH) that specificly inhibits LDH‑A. Sodium oxamate (SO) induces G2/M cell cycle arrest via downregulation of the CDK1/cyclin B1 pathway and promotes apoptosis through enhancement of mitochondrial ROS generation.	Cancer Cell, 2024, S1535-6108(24)00119-3 J Exp Clin Cancer Res, 2024, 43(1):105 J Adv Res, 2024, S2090-1232(24)00025-0
S6675	(R)-GNE-140	(R)-GNE-140 is a selective inhibitor of the LDHA and LDHB with IC50s of 3 nM and 5 nM, respectively. The R enantiomer of GNE-140 is 18-fold more potent than S enantiomer.	J Clin Invest, 2024, 134(17)e177606 J Cachexia Sarcopenia Muscle, 2023, 10.1002/jcsm.13363 J Virol, 2022, jvi0197421
S0108	AZ-33	AZ-33 (LDHA Inhibitor 33) is a potent inhibitor of lactate dehydrogenase A (LDHA) with IC50 of 0.5 μM. LDHA is the key enzyme involved in anaerobic glycolysis which is frequently deregulated in human malignancies.	FASEB J, 2022, 36(3):e22229 Front Mol Biosci, 2021, 8:806650
S8590	GSK 2837808A	GSK 2837808A is a selective LDHA (lactate dehydrogenase A) inhibitor with IC50 of 2.6 nM and 43 nM for hLDHA and hLDHB, respectively.	Nat Neurosci, 2022, 25(7):865-875
S3143	Pyruvic acid	Pyruvic acid (Acetylformic acid) is an important organic chemical intermediate that plays a role in cardiomyocyte pathophysiology and therapy. Pyruvic acid markedly increases the level of lactate dehydrogenase (LDH) and creatine kinase (CK) and reduces the level of Ca²⁺Mg²⁺-ATPase and Na⁺K⁺-ATPase.
S8928	FX11	FX-11(LDHA Inhibitor FX11) is a potent inhibitor of lactate dehydrogenase A (LDHA)) with IC50 of 49.27 μM in BxPc-3 cells.
S4441	Isomalt	Isomalt (Palatinitol) is a sugar alcohol used as an excipient in commercially available solid oral dosage forms. Isomalt stabilizes lactate dehydrogenase (LDH) moderately during freeze-drying.
S9606	Galloflavin	Galloflavin (NSC 107022) 是一种新型的乳酸脱氢酶 (LDH) 抑制剂，其对 LDH-A 和 LDH-B 的 Ki 值分别为 5.46 μM 和 15.06 μM。	J Virol, 2024, 98(1):e0167023
S6871	Sodium oxamate	Sodium oxamate (SO, Aminooxoacetic acid, Oxamic acid) is an inhibitor of lactate dehydrogenase (LDH) that specificly inhibits LDH‑A. Sodium oxamate (SO) induces G2/M cell cycle arrest via downregulation of the CDK1/cyclin B1 pathway and promotes apoptosis through enhancement of mitochondrial ROS generation.	Cancer Cell, 2024, S1535-6108(24)00119-3 J Exp Clin Cancer Res, 2024, 43(1):105 J Adv Res, 2024, S2090-1232(24)00025-0
S6675	(R)-GNE-140	(R)-GNE-140 is a selective inhibitor of the LDHA and LDHB with IC50s of 3 nM and 5 nM, respectively. The R enantiomer of GNE-140 is 18-fold more potent than S enantiomer.	J Clin Invest, 2024, 134(17)e177606 J Cachexia Sarcopenia Muscle, 2023, 10.1002/jcsm.13363 J Virol, 2022, jvi0197421
S0108	AZ-33	AZ-33 (LDHA Inhibitor 33) is a potent inhibitor of lactate dehydrogenase A (LDHA) with IC50 of 0.5 μM. LDHA is the key enzyme involved in anaerobic glycolysis which is frequently deregulated in human malignancies.	FASEB J, 2022, 36(3):e22229 Front Mol Biosci, 2021, 8:806650
S8590	GSK 2837808A	GSK 2837808A is a selective LDHA (lactate dehydrogenase A) inhibitor with IC50 of 2.6 nM and 43 nM for hLDHA and hLDHB, respectively.	Nat Neurosci, 2022, 25(7):865-875
S8928	FX11	FX-11(LDHA Inhibitor FX11) is a potent inhibitor of lactate dehydrogenase A (LDHA)) with IC50 of 49.27 μM in BxPc-3 cells.
S9606	Galloflavin	Galloflavin (NSC 107022) 是一种新型的乳酸脱氢酶 (LDH) 抑制剂，其对 LDH-A 和 LDH-B 的 Ki 值分别为 5.46 μM 和 15.06 μM。	J Virol, 2024, 98(1):e0167023
S3143	Pyruvic acid	Pyruvic acid (Acetylformic acid) is an important organic chemical intermediate that plays a role in cardiomyocyte pathophysiology and therapy. Pyruvic acid markedly increases the level of lactate dehydrogenase (LDH) and creatine kinase (CK) and reduces the level of Ca²⁺Mg²⁺-ATPase and Na⁺K⁺-ATPase.
S4441	Isomalt	Isomalt (Palatinitol) is a sugar alcohol used as an excipient in commercially available solid oral dosage forms. Isomalt stabilizes lactate dehydrogenase (LDH) moderately during freeze-drying.

LDH阻害剤の選択性比較

Tags: LDH inhibitor|LDH agonist|LDH activator|LDH inducer|LDH antagonist|LDH signaling pathway|LDH assay kit