Opioid Receptor

Opioid Receptor製品

• All (21)
• Opioid Receptor阻害剤 (2)
• Opioid Receptor拮抗剤(7)
• Opioid Receptor作動薬(5)
• Opioid Receptorモジュレータ(1)
• 新製品

製品コード	製品名称	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S3066	Naloxone HCl	Naloxone HCl is an opioid inverse agonist drug used to counter the effects of opiate overdose.	Hum Cell, 2022, 10.1007/s13577-022-00671-y Pharmacol Res Perspect, 2022, 10(5):e01016 Toxicol Res (Camb), 2022, 11(3):498-510
S2103	Naltrexone HCl	Naltrexone HCl(PTI-901) is an opioid receptor antagonist used primarily in the management of alcohol dependence and opioid dependence.	Transl Psychiatry, 2024, 14(1):165 Toxicol Res (Camb), 2022, 11(3):498-510 Neuropsychopharmacology, 2021, 10.1038/s41386-021-00962-2
S2722	JTC-801	JTC-801 is a selective opioid receptor-like1 (ORL1) receptor antagonist with IC50 of 94 nM, weakly inhibits receptors δ, κ, and μ.	Heliyon, 2024, 10(11):e32571 Sci Rep, 2023, 13(1):1483 Sci Rep, 2023, 13(1):1483
S2480	Loperamide HCl	Loperamide HCl (ADL 2-1294,R-18553 hydrochloride) is a selective μ-opioid receptor agonist opioid with Ki of 3.3 nM, 15-fold and 350-fold selective over the δ subtype and the κ subtype of the opioid receptor, used against diarrhea resulting from gastroenteritis or inflammatory bowel disease.	Front Neurosci, 2024, 18:1424936 Front Cell Infect Microbiol, 2023, 13:1139152 Anticancer Drugs, 2022, 10.1097/CAD.0000000000001344
S2322	(+)-Matrine	Matrine((+)-Matrine) is an alkaloid found in plants from the Sophora family, which has a variety of pharmacological effects, including anti-cancer effects, and action as a kappa opioid receptor agonist.	J Vet Res, 2024, 68(1):35-44 Transl Oncol, 2023, 35:101712 Front Pharmacol, 2022, 13:1027441
S2503	Racecadotril	Racecadotril (Acetorphan) is a peripherally acting enkephalinase inhibitor with an IC50 of 4.5 μM.
S0009	Asimadoline hydrochloride	Asimadoline hydrochloride (EMD-61753 hydrochloride) is an orally active, selective and peripherally active κ-opioid agonist with IC50s of 5.6 nM (guinea pig) and 1.2 nM (human recombinant).
E0472	BMS-986122	BMS-986122 is a selective, potent positive allosteric modulator of the mu-opioid receptor (µ-OR), shows potentiation of orthosteric agonist-mediated β-arrestin recruitment, adenylyl cyclase inhibition, and G protein activation, and potentiates DAMGO-mediated [35S]GTPγS binding in mouse brain membranes.
S5701	Alvimopan dihydrate (LY246736 dihydrate)	Alvimopan (LY-246736) is a potent, relatively nonselective opioid antagonist with Ki values of 0.77, 4.4, and 40 nM for the μ, δ, and κ opioid receptors, respectively, displaying >100-fold selectivity over other aminergic G-protein-coupled receptors.
E4647New	Aticaprant	Aticaprant (CERC-501, LY-2456302) is a potent, orally bioavailable, centrally-penetrant antagonist of the kappa opioid receptor with a Ki of 0.807 nM. It exhibits an antidepressant effect with the potential to treat major depressive disorder (MDD).
S5507	Trimebutine maleate	Trimebutine maleate is the maleate salt form of trimebutine, which is a spasmolytic agent that regulates intestinal and colonic motility and relieves abdominal pain with antimuscarinic and weak mu opioid agonist effects.
E2868	Naloxegol Oxalate	Naloxegol oxalate (NKTR-118 oxalate) is a μ-opioid-receptor antagonist with a Ki of 33.8 nM. Naloxegol oxalate inhibits opioid binding in μ-opioid receptors in the gastrointestinal tract and effective for alleviating opioid-induced constipation.
S4588	Docusate Sodium	Docusate Sodium (Aerosol OT, Bis(2-ethylhexyl) sulfosuccinate sodium salt, Constonate) is a laxative used to treat constipation, for constipation due to the use of opiates it maybe used with a stimulant laxative, can be taken by mouth or rectally.
E2880	methylnaltrexone bromide	Methylnaltrexone bromide is an antagonist of µ-opioid receptor that reduces the viability of lung cancer cells by inhibiting Src activation.
S2085	Trimebutine	Trimebutine (Mebutin) is an agonist of peripheral mu, kappa and delta opiate receptors, used as spasmolytic agent for treatment of both acute and chronic abdominal pain.
S5935	Alvimopan	Alvimopan (LY 246736, ADL 8-2698) is a potent, relatively nonselective opioid antagonist with Ki values of 0.77, 4.4, and 40 nM for the μ, δ, and κ opioid receptors, respectively, displaying >100-fold selectivity over other aminergic G-protein-coupled receptors.	Curr Issues Mol Biol, 2024, 46(7):6472-6488
S2480	Loperamide HCl	Loperamide HCl (ADL 2-1294,R-18553 hydrochloride) is a selective μ-opioid receptor agonist opioid with Ki of 3.3 nM, 15-fold and 350-fold selective over the δ subtype and the κ subtype of the opioid receptor, used against diarrhea resulting from gastroenteritis or inflammatory bowel disease.	Front Neurosci, 2024, 18:1424936 Front Cell Infect Microbiol, 2023, 13:1139152 Anticancer Drugs, 2022, 10.1097/CAD.0000000000001344
S2322	(+)-Matrine	Matrine((+)-Matrine) is an alkaloid found in plants from the Sophora family, which has a variety of pharmacological effects, including anti-cancer effects, and action as a kappa opioid receptor agonist.	J Vet Res, 2024, 68(1):35-44 Transl Oncol, 2023, 35:101712 Front Pharmacol, 2022, 13:1027441
S0009	Asimadoline hydrochloride	Asimadoline hydrochloride (EMD-61753 hydrochloride) is an orally active, selective and peripherally active κ-opioid agonist with IC50s of 5.6 nM (guinea pig) and 1.2 nM (human recombinant).
S5507	Trimebutine maleate	Trimebutine maleate is the maleate salt form of trimebutine, which is a spasmolytic agent that regulates intestinal and colonic motility and relieves abdominal pain with antimuscarinic and weak mu opioid agonist effects.
S2085	Trimebutine	Trimebutine (Mebutin) is an agonist of peripheral mu, kappa and delta opiate receptors, used as spasmolytic agent for treatment of both acute and chronic abdominal pain.
S2503	Racecadotril	Racecadotril (Acetorphan) is a peripherally acting enkephalinase inhibitor with an IC50 of 4.5 μM.
S5701	Alvimopan dihydrate (LY246736 dihydrate)	Alvimopan (LY-246736) is a potent, relatively nonselective opioid antagonist with Ki values of 0.77, 4.4, and 40 nM for the μ, δ, and κ opioid receptors, respectively, displaying >100-fold selectivity over other aminergic G-protein-coupled receptors.
S3066	Naloxone HCl	Naloxone HCl is an opioid inverse agonist drug used to counter the effects of opiate overdose.	Hum Cell, 2022, 10.1007/s13577-022-00671-y Pharmacol Res Perspect, 2022, 10(5):e01016 Toxicol Res (Camb), 2022, 11(3):498-510
S2103	Naltrexone HCl	Naltrexone HCl(PTI-901) is an opioid receptor antagonist used primarily in the management of alcohol dependence and opioid dependence.	Transl Psychiatry, 2024, 14(1):165 Toxicol Res (Camb), 2022, 11(3):498-510 Neuropsychopharmacology, 2021, 10.1038/s41386-021-00962-2
S2722	JTC-801	JTC-801 is a selective opioid receptor-like1 (ORL1) receptor antagonist with IC50 of 94 nM, weakly inhibits receptors δ, κ, and μ.	Heliyon, 2024, 10(11):e32571 Sci Rep, 2023, 13(1):1483 Sci Rep, 2023, 13(1):1483
E4647New	Aticaprant	Aticaprant (CERC-501, LY-2456302) is a potent, orally bioavailable, centrally-penetrant antagonist of the kappa opioid receptor with a Ki of 0.807 nM. It exhibits an antidepressant effect with the potential to treat major depressive disorder (MDD).
E2868	Naloxegol Oxalate	Naloxegol oxalate (NKTR-118 oxalate) is a μ-opioid-receptor antagonist with a Ki of 33.8 nM. Naloxegol oxalate inhibits opioid binding in μ-opioid receptors in the gastrointestinal tract and effective for alleviating opioid-induced constipation.
E2880	methylnaltrexone bromide	Methylnaltrexone bromide is an antagonist of µ-opioid receptor that reduces the viability of lung cancer cells by inhibiting Src activation.
S5935	Alvimopan	Alvimopan (LY 246736, ADL 8-2698) is a potent, relatively nonselective opioid antagonist with Ki values of 0.77, 4.4, and 40 nM for the μ, δ, and κ opioid receptors, respectively, displaying >100-fold selectivity over other aminergic G-protein-coupled receptors.	Curr Issues Mol Biol, 2024, 46(7):6472-6488
S2480	Loperamide HCl	Loperamide HCl (ADL 2-1294,R-18553 hydrochloride) is a selective μ-opioid receptor agonist opioid with Ki of 3.3 nM, 15-fold and 350-fold selective over the δ subtype and the κ subtype of the opioid receptor, used against diarrhea resulting from gastroenteritis or inflammatory bowel disease.	Front Neurosci, 2024, 18:1424936 Front Cell Infect Microbiol, 2023, 13:1139152 Anticancer Drugs, 2022, 10.1097/CAD.0000000000001344
S2322	(+)-Matrine	Matrine((+)-Matrine) is an alkaloid found in plants from the Sophora family, which has a variety of pharmacological effects, including anti-cancer effects, and action as a kappa opioid receptor agonist.	J Vet Res, 2024, 68(1):35-44 Transl Oncol, 2023, 35:101712 Front Pharmacol, 2022, 13:1027441
S0009	Asimadoline hydrochloride	Asimadoline hydrochloride (EMD-61753 hydrochloride) is an orally active, selective and peripherally active κ-opioid agonist with IC50s of 5.6 nM (guinea pig) and 1.2 nM (human recombinant).
S5507	Trimebutine maleate	Trimebutine maleate is the maleate salt form of trimebutine, which is a spasmolytic agent that regulates intestinal and colonic motility and relieves abdominal pain with antimuscarinic and weak mu opioid agonist effects.
S2085	Trimebutine	Trimebutine (Mebutin) is an agonist of peripheral mu, kappa and delta opiate receptors, used as spasmolytic agent for treatment of both acute and chronic abdominal pain.
E0472	BMS-986122	BMS-986122 is a selective, potent positive allosteric modulator of the mu-opioid receptor (µ-OR), shows potentiation of orthosteric agonist-mediated β-arrestin recruitment, adenylyl cyclase inhibition, and G protein activation, and potentiates DAMGO-mediated [35S]GTPγS binding in mouse brain membranes.
E4647New	Aticaprant	Aticaprant (CERC-501, LY-2456302) is a potent, orally bioavailable, centrally-penetrant antagonist of the kappa opioid receptor with a Ki of 0.807 nM. It exhibits an antidepressant effect with the potential to treat major depressive disorder (MDD).