MNK

亜型選択性的な製品

MNK1 MNK2

MNK製品

All (4)
MNK阻害剤 (4)
新製品

製品コード	製品名称	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S8275	Tomivosertib (eFT-508)	Tomivosertib (eFT-508) is a potent and selective MNK1/2 inhibitor with IC50s of 2.4 nM and 1 nM, respectively. It potentially results in decreased tumor cell proliferation and tumor growth. Tomivosertib (eFT-508) inhibits eIF4E phosphorylation and dramatically downregulates PD-L1 protein abundance.	J Clin Invest, 2024, 134(16)e168393 Sci Adv, 2024, 10(37):eadi7673 PLoS Biol, 2023, 21(8):e3002227
S7421	CGP 57380	CGP 57380 is a potent MNK1 inhibitor with IC50 of 2.2 μM, exhibiting no inhibitory activity on p38, JNK1, ERK1 and -2, PKC, or c-Src-like kinases. CGP 57380 upregulates β-catenin and potentiates radiation-induced apoptosis.	Cell Commun Signal, 2023, 21(1):107 Fundam Clin Pharmacol, 2022, 10.1111/fcp.12759 J Cancer, 2020, 11(4):990-996
S6888	SEL201	SEL-201 (SLV-2436, SEL201-88) is a highly potent and ATP-competitive inhibitor of MNK1 and MNK2 with IC50 of 10.8 nM and 5.4 nM, respectively.	Eur J Pharm Sci, 2022, 177:106278
S6658	ETC-206 (AUM 001)	ETC-206 (AUM 001, ETC-1907206) is an orally available highly selective small-molecule MNK 1/2 inhibitor with IC50s of 64 nM and 86 nM, respectively.
S8275	Tomivosertib (eFT-508)	Tomivosertib (eFT-508) is a potent and selective MNK1/2 inhibitor with IC50s of 2.4 nM and 1 nM, respectively. It potentially results in decreased tumor cell proliferation and tumor growth. Tomivosertib (eFT-508) inhibits eIF4E phosphorylation and dramatically downregulates PD-L1 protein abundance.	J Clin Invest, 2024, 134(16)e168393 Sci Adv, 2024, 10(37):eadi7673 PLoS Biol, 2023, 21(8):e3002227
S7421	CGP 57380	CGP 57380 is a potent MNK1 inhibitor with IC50 of 2.2 μM, exhibiting no inhibitory activity on p38, JNK1, ERK1 and -2, PKC, or c-Src-like kinases. CGP 57380 upregulates β-catenin and potentiates radiation-induced apoptosis.	Cell Commun Signal, 2023, 21(1):107 Fundam Clin Pharmacol, 2022, 10.1111/fcp.12759 J Cancer, 2020, 11(4):990-996
S6888	SEL201	SEL-201 (SLV-2436, SEL201-88) is a highly potent and ATP-competitive inhibitor of MNK1 and MNK2 with IC50 of 10.8 nM and 5.4 nM, respectively.	Eur J Pharm Sci, 2022, 177:106278
S6658	ETC-206 (AUM 001)	ETC-206 (AUM 001, ETC-1907206) is an orally available highly selective small-molecule MNK 1/2 inhibitor with IC50s of 64 nM and 86 nM, respectively.

MNK阻害剤の選択性比較

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