MCT

亜型選択性的な製品

MCT1 MCT4 MCT2

MCT製品

All (9)
MCT阻害剤 (9)
新製品

製品コード	製品名称	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S7339	AZD3965	AZD3965 is a potent, selective and orally available monocarboxylate transporter 1 (MCT1) inhibitor with a binding affinity of 1.6 nM, 6-fold selective over MCT2. Phase 1.	Biomark Res, 2024, 12(1):48 Cell Rep, 2024, 43(9):114686 J Cachexia Sarcopenia Muscle, 2023, 10.1002/jcsm.13363
S8612	α-cyano-4-hydroxycinnamic acid(α-CHCA)	4-Chloro-α-cyanocinnamic acid (α-CHCA) is a classic monocarboxylate transporters (MCT) inhibitor. α-cyano-4-hydroxycinnamate (CHC) has a 10-fold selectivity for MCT1 compared to other MCTs.	J Exp Clin Cancer Res, 2024, 43(1):105 Cancer Cell Int, 2024, 24(1):5 Int J Mol Sci, 2023, 24(1)737
S8747	BAY-8002	BAY-8002 is a novel MCT1 inhibitor and potently suppress bidirectional lactate transport. BAY-8002 significantly increases intratumor lactate levels and transiently modulates pyruvate levels.	Cell Chem Biol, 2023, 30(8):953-964.e9 Nat Commun, 2022, 13(1):5184 Cancers (Basel), 2021, 13(14)3635
S9907	Syrosingopine	Syrosingopine is a dual MCT1 and MCT4 inhibitor with IC50 values of 2500nM and 40 nM in HAP1 cells, respectively.
S9929	VB124	VB124, a potent and selective MCT4 inhibitor, specifically inhibits lactate efflux/import in MDA-MB-231 cells expressing MCT4, and is used for the research of cardiac hypertrophy, heart failure, and metabolism.	Cardiovasc Diabetol, 2024, 23(1):96 J Orthop Surg Res, 2023, 18(1):131
E1549	AZD0095	AZD0095 is a selective and orally active Monocarboxylate transporter 4 (MCT4) inhibitor with IC50 of 1.3 nM and effectively inhibits the tumor growth in NCI-H358 xenografts in combination with Cediranib.
E1751^New	MSC-4381	MSC-4381 (MCT4-IN-1) is an orally active, selective inhibitor of monocarboxylate transporter 4 (MCT4) with an IC50 of 77 nM and a Ki of 11 nM. It has the potential to inhibit lactate efflux and promote intracellular lactate accumulation in MCT4-expressing cell lines.
S7919	AR-C155858	AR-C155858 is a selective monocarboxylate transporter MCT1 and MCT2 inhibitor with Ki value of 2.3 nM and 10 nM, respectively.	bioRxiv, 2024, 10.1101/2024.01.25.577208
S6732	7ACC2	7ACC2 is a potent inhibitor of mitochondrial pyruvate transport 1 (MCT1) with an IC50 value of 10 nM for lactate uptake in SiHa human cervix carcinoma cells.
S7339	AZD3965	AZD3965 is a potent, selective and orally available monocarboxylate transporter 1 (MCT1) inhibitor with a binding affinity of 1.6 nM, 6-fold selective over MCT2. Phase 1.	Biomark Res, 2024, 12(1):48 Cell Rep, 2024, 43(9):114686 J Cachexia Sarcopenia Muscle, 2023, 10.1002/jcsm.13363
S8612	α-cyano-4-hydroxycinnamic acid(α-CHCA)	4-Chloro-α-cyanocinnamic acid (α-CHCA) is a classic monocarboxylate transporters (MCT) inhibitor. α-cyano-4-hydroxycinnamate (CHC) has a 10-fold selectivity for MCT1 compared to other MCTs.	J Exp Clin Cancer Res, 2024, 43(1):105 Cancer Cell Int, 2024, 24(1):5 Int J Mol Sci, 2023, 24(1)737
S8747	BAY-8002	BAY-8002 is a novel MCT1 inhibitor and potently suppress bidirectional lactate transport. BAY-8002 significantly increases intratumor lactate levels and transiently modulates pyruvate levels.	Cell Chem Biol, 2023, 30(8):953-964.e9 Nat Commun, 2022, 13(1):5184 Cancers (Basel), 2021, 13(14)3635
S9907	Syrosingopine	Syrosingopine is a dual MCT1 and MCT4 inhibitor with IC50 values of 2500nM and 40 nM in HAP1 cells, respectively.
S9929	VB124	VB124, a potent and selective MCT4 inhibitor, specifically inhibits lactate efflux/import in MDA-MB-231 cells expressing MCT4, and is used for the research of cardiac hypertrophy, heart failure, and metabolism.	Cardiovasc Diabetol, 2024, 23(1):96 J Orthop Surg Res, 2023, 18(1):131
E1549	AZD0095	AZD0095 is a selective and orally active Monocarboxylate transporter 4 (MCT4) inhibitor with IC50 of 1.3 nM and effectively inhibits the tumor growth in NCI-H358 xenografts in combination with Cediranib.
E1751^New	MSC-4381	MSC-4381 (MCT4-IN-1) is an orally active, selective inhibitor of monocarboxylate transporter 4 (MCT4) with an IC50 of 77 nM and a Ki of 11 nM. It has the potential to inhibit lactate efflux and promote intracellular lactate accumulation in MCT4-expressing cell lines.
S7919	AR-C155858	AR-C155858 is a selective monocarboxylate transporter MCT1 and MCT2 inhibitor with Ki value of 2.3 nM and 10 nM, respectively.	bioRxiv, 2024, 10.1101/2024.01.25.577208
S6732	7ACC2	7ACC2 is a potent inhibitor of mitochondrial pyruvate transport 1 (MCT1) with an IC50 value of 10 nM for lactate uptake in SiHa human cervix carcinoma cells.
E1751^New	MSC-4381	MSC-4381 (MCT4-IN-1) is an orally active, selective inhibitor of monocarboxylate transporter 4 (MCT4) with an IC50 of 77 nM and a Ki of 11 nM. It has the potential to inhibit lactate efflux and promote intracellular lactate accumulation in MCT4-expressing cell lines.

MCT阻害剤の選択性比較

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