CRISPR/Cas9

CRISPR/Cas9製品

• All (10)
• CRISPR/Cas9阻害剤 (2)
• CRISPR/Cas9活性剤(7)
• CRISPR/Cas9モジュレータ(1)
• 新製品

製品コード	製品名称	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S2638	NU7441 (KU-57788)	NU7441 (KU-57788) is a highly potent and selective DNA-PK inhibitor with IC50 of 14 nM and also inhibits mTOR and PI3K with IC50 of 1.7 μM and 5 μM in cell-free assays, respectively. It reduces the frequency of NHEJ while increasing the rate of HDR following Cas9-mediated DNA cleavage.	Nat Cell Biol, 2024, 10.1038/s41556-024-01394-y Nat Commun, 2024, 15(1):6517 Nat Commun, 2024, 15(1):2089
S2775	Nocodazole	Nocodazole is a rapidly-reversible inhibitor of microtubule polymerization, also inhibits Abl, Abl(E255K) and Abl(T315I) with IC50 of 0.21 μM, 0.53 μM and 0.64 μM in cell-free assays, respectively. Nocodazole induces apoptosis.	Nat Cell Biol, 2024, 10.1038/s41556-024-01473-0 Nucleic Acids Res, 2024, gkae605 EMBO J, 2024, 10.1038/s44318-024-00104-6
S7046	Brefeldin A (BFA)	Brefeldin A (BFA) is a lactone antibiotic and ATPase inhibitor for protein transport with IC50 of 0.2 μM in HCT 116 cells, induces cancer cell differentiation and apoptosis. It could also improve the HDR(homology-directed repair) efficiency and be an enhancer of CRISPR-mediated HDR. Brefeldin A is also an inhibitor of autophagy and mitophagy.	Nat Commun, 2024, 15(1):203 Cancer Commun (Lond), 2024, 10.1002/cac2.12583 Cell Rep, 2024, 43(5):114135
S7742	SCR7	SCR7 is a specific DNA Ligase IV inhibitor, which blocks nonhomologous end-joining (NHEJ).	iScience, 2024, 27(2):108814 Nat Commun, 2023, 14(1):4761 Nat Commun, 2023, 14(1):4761
S7827	4-Hydroxytamoxifen (Afimoxifene)	4-Hydroxytamoxifen (Afimoxifene) is the active metabolite of tamoxifen and a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemopreventive treatment of breast cancer.	Nat Commun, 2024, 15(1):2983 Cell Rep Med, 2024, 5(3):101468 Cell Rep, 2024, S2211-1247(23)01591-7
S2579	Zidovudine	Zidovudine (ZDV, Azidothymidine, NSC 602670) is a nucleoside analogue reverse transcriptase inhibitor, used to treat HIV.	Nat Commun, 2024, 15(1):2716 Angiogenesis, 2024, 10.1007/s10456-024-09949-1 bioRxiv, 2024, 10.1101/2024.01.22.576652
S7974	L755507	L-755,507 is characterized as a potent and selective β3 adrenergic receptor partial agonist with EC50 of 0.43 nM. It is also recently identified to enhance CRISPR-mediated homology-directed repair (HDR) efficiency in human induced pluripotent stem cells (iPSCs) and other cell types.	Front Cell Dev Biol, 2023, 11:1276890 bioRxiv, 2023, 10.1101/2023.10.03.560773 Genesis, 2022, 60(1-2):e23465
S8234	RS-1	RS-1 is a RAD51-stimulatory compound, which increases the DNA binding activity of RAD51. It is an HDR(homology-directed repair) enhancer.	J Biomed Sci, 2024, 31(1):68 Int J Biol Sci, 2021, 17(4):1026-1040 Chembiochem, 2021, 22(20):2957-2965
S8844	BRD0539	BRD0539 is a potent inhibitor of spCas9 which disrupts spCas9-DNA binding and exerts dose and temporal control of spCas9 in human cell lines.	Mol Cell, 2021, S1097-2765(21)00168-4
S0102	L 189	L 189 is a novel human DNA ligase inhibitor with IC50 of 5 μM, 9 μM and 5 μM for hLigI, hLigIII and hLigIV, respectively. L 189 inhibits base excision repair (BER) and non-homologous end joining (NHEJ). L 189 specifically sensitizes cancer cells to DNA damage.
S8844	BRD0539	BRD0539 is a potent inhibitor of spCas9 which disrupts spCas9-DNA binding and exerts dose and temporal control of spCas9 in human cell lines.	Mol Cell, 2021, S1097-2765(21)00168-4
S0102	L 189	L 189 is a novel human DNA ligase inhibitor with IC50 of 5 μM, 9 μM and 5 μM for hLigI, hLigIII and hLigIV, respectively. L 189 inhibits base excision repair (BER) and non-homologous end joining (NHEJ). L 189 specifically sensitizes cancer cells to DNA damage.
S2638	NU7441 (KU-57788)	NU7441 (KU-57788) is a highly potent and selective DNA-PK inhibitor with IC50 of 14 nM and also inhibits mTOR and PI3K with IC50 of 1.7 μM and 5 μM in cell-free assays, respectively. It reduces the frequency of NHEJ while increasing the rate of HDR following Cas9-mediated DNA cleavage.	Nat Cell Biol, 2024, 10.1038/s41556-024-01394-y Nat Commun, 2024, 15(1):6517 Nat Commun, 2024, 15(1):2089
S2775	Nocodazole	Nocodazole is a rapidly-reversible inhibitor of microtubule polymerization, also inhibits Abl, Abl(E255K) and Abl(T315I) with IC50 of 0.21 μM, 0.53 μM and 0.64 μM in cell-free assays, respectively. Nocodazole induces apoptosis.	Nat Cell Biol, 2024, 10.1038/s41556-024-01473-0 Nucleic Acids Res, 2024, gkae605 EMBO J, 2024, 10.1038/s44318-024-00104-6
S7046	Brefeldin A (BFA)	Brefeldin A (BFA) is a lactone antibiotic and ATPase inhibitor for protein transport with IC50 of 0.2 μM in HCT 116 cells, induces cancer cell differentiation and apoptosis. It could also improve the HDR(homology-directed repair) efficiency and be an enhancer of CRISPR-mediated HDR. Brefeldin A is also an inhibitor of autophagy and mitophagy.	Nat Commun, 2024, 15(1):203 Cancer Commun (Lond), 2024, 10.1002/cac2.12583 Cell Rep, 2024, 43(5):114135
S7742	SCR7	SCR7 is a specific DNA Ligase IV inhibitor, which blocks nonhomologous end-joining (NHEJ).	iScience, 2024, 27(2):108814 Nat Commun, 2023, 14(1):4761 Nat Commun, 2023, 14(1):4761
S7827	4-Hydroxytamoxifen (Afimoxifene)	4-Hydroxytamoxifen (Afimoxifene) is the active metabolite of tamoxifen and a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemopreventive treatment of breast cancer.	Nat Commun, 2024, 15(1):2983 Cell Rep Med, 2024, 5(3):101468 Cell Rep, 2024, S2211-1247(23)01591-7
S7974	L755507	L-755,507 is characterized as a potent and selective β3 adrenergic receptor partial agonist with EC50 of 0.43 nM. It is also recently identified to enhance CRISPR-mediated homology-directed repair (HDR) efficiency in human induced pluripotent stem cells (iPSCs) and other cell types.	Front Cell Dev Biol, 2023, 11:1276890 bioRxiv, 2023, 10.1101/2023.10.03.560773 Genesis, 2022, 60(1-2):e23465
S8234	RS-1	RS-1 is a RAD51-stimulatory compound, which increases the DNA binding activity of RAD51. It is an HDR(homology-directed repair) enhancer.	J Biomed Sci, 2024, 31(1):68 Int J Biol Sci, 2021, 17(4):1026-1040 Chembiochem, 2021, 22(20):2957-2965
S2579	Zidovudine	Zidovudine (ZDV, Azidothymidine, NSC 602670) is a nucleoside analogue reverse transcriptase inhibitor, used to treat HIV.	Nat Commun, 2024, 15(1):2716 Angiogenesis, 2024, 10.1007/s10456-024-09949-1 bioRxiv, 2024, 10.1101/2024.01.22.576652