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S7455 Resatorvid (TAK-242) Resatorvid (TAK-242, CLI-095) is a small-molecule-specific inhibitor of Toll-like receptor (TLR) 4 signaling, blocking LPS-induced production of NO, TNF-α and IL-6 in macrophages with IC50 of 1.8 nM, 1.9 nM and 1.3 nM, respectively. Resatorvid downregulates expression of TLR4 downstream signaling molecules MyD88 and TRIF. Resatorvid inhibits autophagy.
Cancer Cell, 2024, S1535-6108(24)00119-3
Nat Commun, 2024, 15(1):7662
Redox Biol, 2024, 70:103072
S7455 Resatorvid (TAK-242) Resatorvid (TAK-242, CLI-095) is a small-molecule-specific inhibitor of Toll-like receptor (TLR) 4 signaling, blocking LPS-induced production of NO, TNF-α and IL-6 in macrophages with IC50 of 1.8 nM, 1.9 nM and 1.3 nM, respectively. Resatorvid downregulates expression of TLR4 downstream signaling molecules MyD88 and TRIF. Resatorvid inhibits autophagy.
Cancer Cell, 2024, S1535-6108(24)00119-3
Nat Commun, 2024, 15(1):7662
Redox Biol, 2024, 70:103072

TRIF阻害剤の選択性比較

Tags: TRIF inhibitor|TRIF agonist|TRIF activator|TRIF inducer|TRIF antagonist|TRIF signaling pathway|TRIF assay kit