製品コード	製品名	製品説明	Selective / Pan	IC50 / Ki
S8479	LLY-284	LLY-284 is the diastereomer of LLY-283, which is a potent and selective SAM-competitive chemical probe for PRMT5. LLY-284 is much less active than LLY-283 and can be used as a negative control for LLY-283.	Selective
S8664	Pemrametostat (GSK3326595)	Pemrametostat (GSK3326595, EPZ015938) is an orally active, potent and selective inhibitor of protein arginine methyltransferase 5 (PRMT5) and potently inhibits tumor growth in vitro and in vivo in animal models.	Selective
S8624	Onametostat (JNJ-64619178)	Onametostat (JNJ-64619178) is a PRMT5 inhibitor with high selectivity and potency (subnanomolar range, PRMT5-MEP-50 IC50=0.14 nM) under different in vitro and cellular conditions, paired with favorable pharmacokinetics and safety properties.	Selective	PRMT5, IC50: 0.14 nM
S8111	GSK591	GSK591 (EPZ015866, GSK3203591) is a potent selective inhibitor of the arginine methyltransferase PRMT5 with IC50 of 4 nM.	Selective	PRMT5, IC50: 4 nM
S7748	EPZ015666 (GSK3235025)	EPZ015666 (GSK3235025) is a potent, selective and orally bioavailable PRMT5 inhibitor with K_i of 5 nM, >20,000-fold selectivity over other PMTs.	Selective	PRMT5, Ki: 5 nM
S8883	LLY-283	LLY-283 is a novel and selective inhibitor of protein arginine methyltransferase 5 (PRMT5). LLY-283 inhibits PRMT5 enzymatic activity in vitro and in cells with IC50 of 22 nM and 25 nM, respectively. LLY-283 shows antitumor activity.	Selective	PRMT5, IC50: 22 nM; PRMT5, IC50: 25 nM
S8209	HLCL-61 HCL	HLCL-61 hydrochloride is a potent and selective PRMT5 inhibitor for the treatment of acute myeloid leukemia.	Selective	PRMT5, IC50: 16.74 μM

PRMT5 選択性 阻害剤 | 化学物質

PRMT5 選択性阻害剤 | 化学物質